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Background: The osteoclastogenesis RANKL gene plays a key role in bone remodeling. The hypomethylation of its promoter region may cause osteoporosis. The present study aimed to elucidate the influence of physical activity on DNA methylation changes of RANKL promoter cytosine-phosphate-guanine (CpG)-rich region in active and sedentary adults and to assess the effect of aerobic and strength training on RANKL DNA methylation changes among Tunisian-North African adults. Methods: A total of 104 participants including 52 adults (58% males and 42% females) and 52 adults (31% males and 69% females) were recruited for the observational and interventional part of the study, respectively. The intervention consisted of 12 weeks of aerobic training (30 min/session) followed by 10 minutes of strengthening exercises. All participants completed the International Physical Activity Questionnaire and provided blood samples for quantitative methylation-specific polymerase chain reaction (PCR) analysis. Results: The study revealed a significant difference (P = 6 × 10−10) in the methylation level of the RANKL promoter region between active and sedentary adults, with a 6.68-fold increase observed in the active group. After the intervention, both the trained (P = 41 × 10−5) and untrained (P =.002) groups displayed high methylation levels in the RANKL promoter region. In addition, the trained group exhibited significant improvements in heart rate (P = 2.2 × 10−16), blood pressure (P = 39 × 10−3), maximal oxygen uptake (P = 1.5 × 10−7), and fat mass (P = 7 × 10−4). Conclusion: Exploring epigenetic modifications in the RANKL promoter region may contribute to a more comprehensive understanding of the complexity of osteoporosis. This suggests that aerobic/strength training could potentially improve the bone system, reducing its vulnerability to osteoporosis by increasing RANKL DNA methylation. [ABSTRACT FROM AUTHOR]

Introduction: Physical training induces iron status impairment in athletic females in the short term and over prolonged periods. Nevertheless, the existing literature lacks a comprehensive evaluation of the differential impacts of aerobic vs. anaerobic training on hematological indices and iron status among adolescent female athletes. The aim of this study was to assess the hematological factors and iron status in aerobic vs. anaerobic training in athletic females. Methods: This observational, cross-sectional study recruited twenty-five adolescent athletic females; thirteen of them participated in an aerobic sport (long-distance running), while twelve of them participated in an anaerobic sport (broad jumping). Hematological factors were assessed by analyzing blood concentrations of hemoglobin (Hb), hematocrit (Hct), red blood cell (RBC) count, mean corpuscular volume (MCV), and mean corpuscular hemoglobin concentration (MCHC), while the iron status assessment was conducted through evaluating levels of serum transferrin and serum ferritin. Results: Athletic females who participated in the aerobic sport showed significantly lower Hb (MD −0.84; 95% CI −1.63: −0.04; p = 0.041), Hct (MD −5.49; 95% CI −7.86: −3.12; p = 0.0001), RBC count (MD −0.37; 95% CI −0.57: −0.17; p = 0.001), and MCV (MD −5.15; 95% CI −9.41: −0.89; p = 0.020), as well as significantly higher MCHC (MD 2.99; 95% CI 2.18: 3.79; p = 0.0001) and serum transferrin (MD 46.77; 95% CI 10.95: 82.59; p = 0.013) than athletic females who participated in the anaerobic sport. However, there was an insignificant difference in serum ferritin levels (MD −3.18; 95% CI −11.49: 5.13; p = 0.437) between both groups. Conclusion: Except for the ferritin level that exhibited an insignificant difference between aerobic and anaerobic training, aerobic training was associated with a worse impact on the hematological factors and iron status than anaerobic training in adolescent athletic females. [ABSTRACT FROM AUTHOR]

This study aimed to evaluate the intensity of posing training in male bodybuilders by comparing it to vigorous intensity parameters and examining the effects of stimulant usage and preparation phases. Specifically, this study compared posing training to established vigorous intensity benchmarks using metabolic equivalents (METs) and heart rate (HR) responses and assessed differences between athletes using stimulants versus those not using stimulants, as well as during peak week versus other preparation phases. Fifteen male bodybuilding athletes (mean age: 32.07 ± 7.82 years; mean body mass: 92.89 ± 9.06 kg; mean height: 1.76 ± 0.05 m; mean body mass index: 29.78 ± 2.24 kg/m²) completed four compulsory posing sets. Findings demonstrated that posing training can be classified as vigorous training intensity using METs (mean difference of −0.50 METs, p = 0.067, ES = −0.51) and maximum HR (mean difference of 14.55 bpm, p = 0.009, ES = 0.79) compared to the established values of 6.0 METs and 77% vigorous intensity of %HRmax, respectively. Additionally, athletes using stimulants exhibited higher ratings of perceived exertion (RPE) of 2.20 arbitrary units (p = 0.008) and maximum HR (mean difference of 24.37 bpm, p = 0.005, ES = 0.79) compared to those not using stimulants. During peak week, athletes showed higher RPE of 2.38 arbitrary units (p = 0.004) and maximum HR (mean difference of 14.55 bpm, p = 0.009, ES = 0.79) compared to other preparation phases. These results indicate that bodybuilding posing training meets the criteria for vigorous exercise intensity and that stimulant use and peak week significantly affect physiological responses and perceived exertion. Novelty: This study is novel in classifying bodybuilding posing training as vigorous intensity exercise using metabolic equivalents (METs) and heart rate (HR) responses. It provides empirical evidence showing that posing training meets the vigorous intensity benchmarks, with METs and %HRmax values comparable to established vigorous exercise standards. The research highlights the novel finding that stimulant usage and the peak week phase of preparation significantly influence physiological responses and perceived exertion in bodybuilders. Specifically, athletes using stimulants and those in peak week displayed higher ratings of perceived exertion (RPE) and maximum heart rates, indicating that these factors notably affect the intensity and perceived difficulty of posing training. [ABSTRACT FROM AUTHOR]

This work is an analytical review dedicated to the search for driver mechanisms of epigenetic changes in atherosclerosis pathogenesis. The disease affects the cardiovascular system in the adult population, mainly the elderly and senile. Atherosclerosis is accompanied by progressive deposition of cholesterol and lipoproteins in vessels intima with inflammation, narrowing of the lumen, and impaired blood supply to tissues and organs. These processes are characterized by changes in the expression of the CACNA1C, GABBR2, TCF7L2, DCK, NRP1, PBX1, FANCC, CCDC88C, TCF12, and ABLIM1 genes. Prevention of atherosclerosis is physical activity, the mechanisms of which are not fully understood. Experimental models have shown that regular training not only has a protective effect on the development of atherosclerosis but also inhibits the progression of an already developed disease with a decrease in vascular stenosis and an increase in the concentration of collagen and elastin and matrix metalloproteinases in plaques. These results have been confirmed by clinical studies. The purpose of this review was to systematize the accumulated results on the causes of epigenetic changes, including those under the influence of regular training, causing changes in the expression of specific microRNAs in atherosclerosis. It was found that physical exercise in Apo–/– mice increases the expression of miR-126 and miR-146a (inhibiting the TLR4 and TRAF genes), miR-20a (affecting PTEN), and miR-492 (suppressing RETN gene mRNA). Clinical studies have shown an increase in the levels of miR-146a, miR-126, miR-142-5p, and miR-424-5p and a decrease in the transcription of miR-15a-5p, miR-93-5p, and miR-451 under the influence of aerobic training. It has been suggested that the drivers of epigenetic changes in atherosclerosis are transposons pathologically activated during aging, the transcription of which can change under the influence of physical training, which is accompanied by impaired expression of long noncoding RNAs and microRNAs derived from transposons. Analysis of the published data allowed us to identify 36 such microRNAs, 25 of which showed identical changes in levels during aging and atherosclerosis. [ABSTRACT FROM AUTHOR]

Background/Objectives: Physical exercise (PE) has been shown to have positive effects on the symptoms associated with autism spectrum disorder (ASD). However, there is still no consensus on the most appropriate PE intervention model. With this in mind, we developed a program with the aim of determining the effects of PE on physical fitness, with a view to applying it as a potential treatment. Methods: Using an experimental methodology, this research work will recruit 18 institutionalized young people and adults who will be allocated to one of two groups, namely (i) the youth training group and (ii) the adult training group, using low-cost materials. Both intervention groups will perform 90 min of training per session, twice a week, for 12 weeks. Evaluations will be carried out at baseline and month 3. The impact of the exercise program will be assessed based on the variables of anthropometry, body composition, cardiovascular response, and cardiorespiratory fitness. Results: The results of this study will contribute to the development of more effective strategies, prescription recommendations, and interventions as a guarantee in future programs of better and greater adherence to PE by institutionalized individuals with ASD. Conclusions: In addition, we intend to make the PE program available if it promotes positive effects in the target population. [ABSTRACT FROM AUTHOR]

Objective: The purpose of this study was to compare different intensities of aerobic exercise for patients with knee osteoarthritis (KOA) and type 2 diabetes mellitus (T2DM) in terms of glycemic control, pain relief, and functional outcomes. Methods: A prospective randomized open-label parallel multicenter clinical trial conducted at two hospitals in Shanghai and Sichuan that included 228 patients with type 2 diabetes mellitus (T2DM) and knee osteoarthritis (KOA). Enrollment occurred between January 2021 and February 2023, and follow-up was completed in September 2023. Participants were randomized to threshold training/high-intensive stationary cycling training (n=76), intensive endurance/moderate-intensive stationary cycling training (n=77), and regular rehabilitation programs (n=75). The primary outcome at the 6-month follow-up was the HbA1c level. Key secondary outcomes included the Knee Injury and Osteoarthritis Outcome Score (KOOS) subscale of pain and quality of life. Results: Of 228 patients, 212 (93%) completed the trial. The mean adjusted (sex, baseline BMI, and baseline outcome measures) HbA1c level at the 6-month follow-up decreased significantly in the high-intensive training group compared with other groups (high-intensity group vs. control group; difference, 0.51%, 95% confidence interval, 0.05% to 1.15%). Mean KOOS subscales of pain and quality of life were statistically significantly different between the control group and moderate-intensity or high-intensity groups, but no statistical differences were noted between the different intensities of aerobic exercise. Patients in all groups achieved a greater reduction in BMI but no significant differences were observed between groups. Conclusion: In KOA and T2DM patients, high-intensity stationary cycling can significantly improve glycemic control compared with moderate-intensity and regular rehabilitation programs. However, high-intensity stationary cycling does not exert a superior effect on pain relief and functional improvement for KOA compared with moderate-intensity and regular rehabilitation programs. [ABSTRACT FROM AUTHOR]

Background: Concurrent training (CT) is emerging as a practical and effective approach to enhance body composition, cardiovascular function, and muscle mass, thereby elevating overall individual health. This study aims to systematically investigate the effects of short- and long-term concurrent aerobic and resistance training on circulating irisin levels in overweight or obese individuals. Methodology: The electronic databases, including China National Knowledge Infrastructure, PubMed, Embase, Wan Fang Database, and Web of Science, were systematically searched for articles on "concurrent training" and "irisin" published from their inception to 30 November 2023. The pooled effect size was determined using standardized mean difference (SMD) and corresponding 95% confidence intervals (CIs). The study protocol received registration with the International Prospective Register of Systematic Reviews (CRD42023494163). Results: All nine studies, encompassing a total of 264 participants, were randomized controlled trials and met the eligibility criteria. Results indicate that short- and long-term concurrent training moderately increased circulating irisin levels compared to the control group (SMD = 0.56, 95% CI [0.33–0.80], p = 0.00; I2 = 36.6%, heterogeneity p = 0.106). Subgroup analyses revealed that both equal to or less than 10 weeks (SMD = 0.78, 95% CI [0.18–1.37], p = 0.01; I2 = 62.3%, heterogeneity p = 0.03) and more than 10 weeks (SMD = 0.45, 95% CI [0.14–0.76], p = 0.00; I2 = 0%, heterogeneity p = 0.54) of concurrent training significantly increased circulating irisin levels in overweight or obese individuals. There were no significant between-group differences (I2 = 0%, p = 0.34). Additionally, concurrent training significantly increased irisin levels in overweight or obese participants (SMD = 1.06, 95% CI [0.34–1.78], p = 0.00; I2 = 50.6%, heterogeneity p = 0.13) and in type 2 diabetes patients (SMD = 0.70, 95% CI [0.30–1.10], p = 0.00; I2 = 0%, heterogeneity p = 0.99). However, no significant effect was observed in patients with metabolic syndrome (SMD = 0.21, 95% CI [−0.25–0.68], p = 0.37; I2 = 38.7%, heterogeneity p = 0.18). There were significant between-group differences (I2 = 53.9%, p = 0.11). Lastly, concurrent training significantly increased circulating irisin levels in overweight or obese individuals aged 45-60 years (SMD = 0.56, 95% CI [0.25–0.86], p = 0.00; I2 = 6.5%, heterogeneity p = 0.38), and a significant increase in irisin levels was observed 12 h post-intervention (SMD = 0.70, 95% CI [0.35–1.05], p = 0.00; I2 = 0%, heterogeneity p = 0.74). However, none of the above categorical variables showed significant between-group differences. Conclusions: Short- and long-term concurrent training can effectively improve circulating irisin levels in overweight or obese individuals. However, the effects of short- and long-term concurrent training should consider the participants' health status, age, and the timing of post-exercise measurements to maximize health benefits. [ABSTRACT FROM AUTHOR]

Background: /Objective. An explosion in global obesity epidemic poses threats to the healthcare system by provoking risks of many debilitating diseases, including cognitive dysfunction. Physical activity has been shown to alleviate the deleterious effects of obesity-associated cognitive deficits across the lifespan. Given the strong neuroprotective role of brain-derived neurotrophic factor (BDNF) and exercise training as a known modulator for its elevation, this systematic review sought to examine the strength of the association between exercise and BDNF levels in healthy people with overweight and obesity. Methods: Six electronic databases (PubMed, MEDLINE, EMBASE, Web of Science, Ovid Nursing Database, and SPORTDiscus) were searched from their inceptions through December 2022. The primary outcome of interest was BDNF levels. Interventional studies (randomized and quasi-experimental) with English full text available were included. Risk of bias of the included studies was assessed using the Physiotherapy Evidence Database Scale. Data were extracted for meta-analyses by random-effects models. Results: Thirteen studies (n = 750), of which 69.2% (9/13) had low risk of bias, were included. In the meta-analysis, exercise interventions had no significant effect on resting BDNF levels (standardized mean difference: −0.30, 95% CI -0.80 to 0.21, P = 0.25). Subgroup analyses also indicated no effects of age and types of control groups being compared on moderating the association. Conclusion: To further inform the role of BDNF in obesity-related cognitive functioning, rigorous studies with larger samples of participants and raw data available were imperatively deserved.

Objectives: This study examined how women with low back pain (LBP) responded to comprehensive physical exercises (CPEs) combined with cognitive functional therapy (CFT) in terms of pain, disability and postural sway (PS). Methods: A total of 45 women with non-specific chronic LBP (NSCLBP) participated in this quasi-experimental study. The participants were randomly assigned to the CPEs, CPEs combined with CFT and control group (CG) (15 participants per group). The McGill pain questionnaire, Roland-Morris disability questionnaire, and Zebris platform were used to assess pain, disability and PS in anteroposterior (AP) and mediolateral (ML) directions with eyes open and closed. For eight weeks, the participants engaged in both CPEs and CPEs combined with CFT. The CG continued their usual routine. The multivariate analysis of variance statistical test with repeated measures design was used to analyze the data (P

We examined the effects of resistance and aerobic exercise on the gene expression and biometabolic processes of aging skeletal muscle in senescence-accelerated mouse/prone 8 mice, a model of sarcopenia, and compared them with senescence-accelerated mouse/resistant 1 mice acting as controls. We found that exercise improved muscle strength, endurance, fiber size, also modulated genes and pathways related to synaptic transmission, potassium transport, JAK-STAT signaling, and PI3K-Akt signaling. Our results suggested that BDNF, JAK2, RhoC, Myh6, Stat5a, Tnnc1, and other genes may mediate the beneficial effects of exercise on sarcopenia through these pathways.

OBJECTIVE: The main clinical manifestations of knee osteoarthritis are pain, swelling, stiffness, and limited activity, which have a serious impact on the life of patients. Exercise therapy can effectively improve the related symptoms of patients with knee osteoarthritis. This paper uses the method of network meta-analysis to compare the efficacy of different exercise types in the treatment of knee osteoarthritis. METHODS: CNKI, WanFang, PubMed, Embase, Cochrane Library, Web of Science, Scopus, Ebsco, SinoMed, and UpToDate were searched with Chinese search terms “knee osteoarthritis, exercise therapy” and English search terms “knee osteoarthritis, exercise”. Randomized controlled trials on the application of different exercise types in patients with knee osteoarthritis from October 2013 to October 2023 were collected. The outcome measures included visual analog scale, Western Ontario and McMaster Universities Osteoarthritis Index score, Timed Up and Go test, and 36-item short form health survey. Literature quality analysis was performed using the Cochrane Manual recommended tool for risk assessment of bias in randomized controlled trials. Two researchers independently completed the data collection, collation, extraction and analysis. RevMan 5.4 and Stata 18.0 software were used to analyze and plot the obtained data. RESULTS: A total of 29 articles with acceptable quality were included, involving 1 633 patients with knee osteoarthritis. The studies involved four types of exercise: aerobic training, strength training, flexibility/skill training, and mindfulness relaxation training. (1) The results of network meta-analysis showed that compared with routine care/health education, aerobic training could significantly improve pain symptoms (SMD=-3.26, 95%CI: -6.33 to -0.19, P < 0.05); strength training (SMD=-0.79, 95%CI: -1.34 to -0.23, P < 0.05) and mindfulness relaxation training (SMD=-0.79, 95%CI: -1.23 to -0.34, P < 0.05) could significantly improve the function of patients. Aerobic training (SMD=-1.37, 95%CI: -2.24 to -0.51, P < 0.05) and mindfulness relaxation training (SMD=-0.41, 95%CI: -0.80 to -0.02, P < 0.05) could significantly improve the functional mobility of patients. Mindfulness relaxation training (SMD=0.70, 95%CI: 0.21-1.18, P < 0.05) and strength training (SMD=0.42, 95%CI: 0.03-0.81, P < 0.05) could significantly improve the quality of life of patients. (2) The cumulative probability ranking results were as follows: pain: aerobic training (86.6%) > flexibility/skill training (60.1%) > strength training (56.8%) > mindfulness relaxation training (34.7%) > routine care/health education (11.7%); Knee function: strength training (73.7%) > mindfulness relaxation training (73.1%) > flexibility/skill training (56.1%) > aerobic training (39.9%) > usual care/health education (7.6%); Functional mobility: aerobic training (94.7%) > mindfulness relaxation training (65.5%) > strength training (45.1%) > flexibility/skill training (41.6%) > routine care/health education (3.2%); Quality of life: mindfulness relaxation training (91.3%) > strength training (68.0%) > flexibility/skill training (44.3%) > aerobic training (34.0%) > usual care/health education (12.3%). CONCLUSION: (1) Exercise therapy is effective in the treatment of knee osteoarthritis, among which aerobic training has the best effect on relieving pain and improving functional mobility. Strength training and mindfulness relaxation training has the best effect on improving patients’ function. Mindfulness relaxation training has the best effect on improving the quality of life of patients. (2) Limited by the quality and quantity of the included literature, more high-quality studies are needed to verify it. [ABSTRACT FROM AUTHOR]

Copyright of Retos: Nuevas Perspectivas de Educación Física, Deporte y Recreación is the property of Federacion Espanola de Asociaciones de Docentes de Educacion Fisica and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Retos: Nuevas Perspectivas de Educación Física, Deporte y Recreación is the property of Federacion Espanola de Asociaciones de Docentes de Educacion Fisica and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Introduction: Increased nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) signaling in neuroblastoma cells may represent an autocrine system to support cancer growth, invasion, and metastasis. Therefore, this research aimed to assess the simultaneous effect of aerobic exercise and nano curcumin supplementation on the expression of BDNF and NGF genes in rats with brain tumors. Material & Methods: A total of 35 male Wistar rats were randomly assigned to seven groups of five: healthy base control, healthy control of 4 weeks, base cancer control, four weeks of cancer control, cancer+nanocolumns, cancer+aerobic, and cancer exercise+aerobic exercise+nanocolumns. After injecting cancer cells into the mice's forehead cortex, with 80 mg/kg supplement gauges for 28 days, five days a week, enter the main aerobic exercise program on the rotating tape for four weeks, three days a week. At 18 m/min, they were 25-40 minutes. In the end, the mice were sacrificed, and data were collected. Results: The expression of the BDNF gene in the training+nano curcumin group was significantly decreased compared to the baseline cancer control and 4-week cancer (P0.05). Discussion & Conclusion: It seems that aerobic exercise along with nanocurcumin can possibly increase neurogenesis in rats with brain cancer by reducing BDNF and NGF gene expression through receptors.

In recent years, the number of elderly individuals has been increasing worldwide. With this increase, there is also an increase in many factors that negatively affect the quality of life of elderly individuals and prevent them from performing daily living activities. The increase in these factors causes new problems to arise in the lives of elderly individuals. In line with aging, various problems are observed biologically, phenotypically, and functionally. These problems cause serious problems in the lives of elderly individuals. In addition to the natural aging process, frailty and pre-frailty phenotype often accompany these individuals due to a decrease in functional capacity and muscle strength, disrupting the healthy aging process. Especially with the inclusion of a frailty diagnosis, elderly individuals struggle to maintain their daily activities, and their quality of life is negatively affected. Additionally, physical activity and exercise have a very important place in fragile societies in order to eliminate these negativities. However, just because elderly individuals experience the same problems does not necessarily mean that the same exercise programs will be applied. The symptoms of problems experienced by elderly individuals should be examined separately. On the other hand, in addition to the problem experienced, other disorders such as frailty may be observed in elderly individuals. Therefore, it is important to comprehensively evaluate elderly individuals for frailty and develop individualized rehabilitation programs. The aim of this study is to emphasize the importance of physical activity and promote healthy aging in elderly frail individuals. In conclusion, this study emphasizes the importance of physical activity in minimizing the effects of frailty and potentially reversing frailty-related outcomes in elderly individuals.

Due to limited studies, we systematically reviewed evidence on the impact of physical exercise on intraocular pressure (IOP) in glaucoma patients, adhering to PRISMA guidelines. Using MEDLINE/Web of Science, PubMed, and Scopus, we selected English, Portuguese, or Spanish studies excluding case reports and yoga-based interventions. From 1001 records, 15 studies were independently evaluated. Evaluated through the MMAT scoring system, two quantitative randomised controlled studies scored 100% while 13 non-randomised studies averaged 84.62%. Our findings indicated that both aerobic and resistance training led to an immediate IOP reduction post-exercise. However, these findings were largely from single-session experiments. In contrast, the effects of longer-term exercise programmes on IOP varied. Although our review underscores the potential utility of exercise in IOP management, the evidence remains inconclusive due to variations in study design, participant demographics, and exercise parameters. This lack of consistency in the research highlights the necessity for larger, standardised, and longer-term studies to robustly corroborate these preliminary findings. [ABSTRACT FROM AUTHOR]

Background: Patients with central core myopathy (CCM) can be at risk of exercise-induced rhabdomyolysis and myalgia. Despite its possible positive effects, physical training has been long avoided in these patients as no population-specific exercise adaption strategies have been developed. Here we present the case of a 17-year-old male CCM patient who underwent a 3- month training program tailored to a preliminary test aimed at assessing his physical exertion tolerance measured via changes in serum creatine kinase (CK). Methods: The preliminary tolerance test consisted of three 25-minute sessions (one session per week) of physical exercise (aerobic, resistance and mixed) at an intensity quantified as level 6 of the Borg Category Ratio (CR) 0--10 scale. A blood sample to assess CK was conducted 36 h following eachsession. The intervention consisted of a training program (three sessions per week) including both resistance and aerobic exercises concomitant with a personalized nutritional plan. Before and after intervention, a battery of metabolic (indirect calorimetry, bioimpedance) and cardiopulmonary (CPET) tests were performed. Results: After training, improvements of the anaerobic threshold (+6.9%), normalized VO2 max (+15%) and body composition (muscle mass, +1.1 kg; fat mass, -1.1 kg were observed without pain, rhabdomyolysis, and blood CK augmentation compared to pretraining values. Conclusion: Our results highlight that a mixed aerobic/resistance training, properly tailored and supported by a specific nutritional plan, may safely improve the physical fitness and body composition in a CCM patient. Dosing exercise-induced CK serum change following Borg CR-10 intensity assessment, may be useful to correctly tailor physical exercise in these patients. [ABSTRACT FROM AUTHOR]

Purpose: The primary aims of this study were to examine the effects of 9 weeks of aerobic training, comprising three 30‐min sessions per week, on V̇O2max, inhibitory control, and plasma brain‐derived neurotrophic factor (BDNF) levels among adolescents aged 16–19 years. Methods: One hundred twenty‐one untrained or recreationally active adolescents from a Danish high school were enrolled in the study, with 58 females (17.8 ± 0.8 years) and 27 males (18.0 ± 0.9 years) completing it. Participants were randomly divided into three groups performing aerobic training at either moderate‐intensity (MIT: 60%–70% heart rate reserve [HRR]) or high‐intensity (HIT: 80%–100% HRR) or a passive control group (CON) continuing their habitual lifestyle. Both the training groups exercised for 3×30 min per week for 9 weeks using a combination of cycling and running. Before and after the intervention period maximal oxygen uptake (V̇O2max) and the primary outcomes (inhibitory control measured by a modified flanker task, and resting plasma levels of BDNF) were evaluated. Results: After the intervention period, the HIT group demonstrated a larger increase in V̇O2max compared to both the CON and MIT groups, while no significant effects were observed on inhibitory control or plasma BDNF levels in any training group. However, compared to the CON group, the HIT group exhibited a tendency for greater improvement in the flanker interference score (accuracy), attributable to enhanced accuracy on the incongruent stimuli from pre to post. Conclusion: Aerobic training in adolescents increased cardiorespiratory fitness in an intensity‐dependent manner, but no clear effects were observed on neither inhibitory control nor resting plasma BDNF levels. Clinical Trial Registration: ClinicalTrials.gov: NCT02075944. [ABSTRACT FROM AUTHOR]

Several genetic markers have shown associations with muscle performance and physical abilities, but the response to exercise therapy is still unknown. The aim of this study was to test the response of patients with long COVID through an aerobic physical therapy strategy by the Nordic walking program and how several genetic polymorphisms involved in muscle performance influence physical capabilities. Using a nonrandomized controlled pilot study, 29 patients who previously suffered from COVID-19 (long COVID = 13, COVID-19 = 16) performed a Nordic walking exercise therapy program for 12 sessions. The influence of the ACE (rs4646994), ACTN3 (rs1815739), AMPD1 (rs17602729), CKM (rs8111989), and MLCK (rs2849757 and rs2700352) polymorphisms, genotyped by using single nucleotide primer extension (SNPE) in lactic acid concentration was established with a three-way ANOVA (group × genotype × sessions). For ACE polymorphism, the main effect was lactic acid (p = 0.019). In ACTN3 polymorphism, there were no main effects of lactic acid, group, or genotype. However, the posthoc analysis revealed that, in comparison with nonlong COVID, long COVID increased lactic acid concentrations in Nordic walking sessions in CT and TT genotypes (all p < 0.05). For AMPD1 polymorphism, there were main effects of lactic acid, group, or genotype and lactic acid × genotype or lactic acid × group × genotype interactions (all p < 0.05). The posthoc analysis revealed that, in comparison with nonlong COVID, long COVID increased lactic acid concentrations in Nordic walking sessions in CC and CT genotypes (all p < 0.05). Physical therapy strategy through Nordic walking enhanced physical capabilities during aerobic exercise in post-COVID19 patients with different genotypes in ACTN3 c.1729C>T and AMPD1 c.34C>T polymorphisms. These findings suggest that individuals who reported long COVID who presumably exercised less beforehand appeared to be less able to exercise, based on lactate levels, and the effect of aerobic physical exercise enhanced physical capabilities conditioned by several genetic markers in long COVID patients. [ABSTRACT FROM AUTHOR]

Purpose: Although the cardioprotective benefits of exercise training are well known, the effects of training on dexamethasone (DEX)-induced arterial stiffness are still unclear. This study was aimed at investigating the mechanisms induced by training to prevent DEX-induced arterial stiffness. Methods: Wistar rats were allocated into 4 groups and submitted to combined training (aerobic and resistance exercises, on alternate days, 60% of maximal capacity, for 74 d) or were kept sedentary: sedentary control rats (SC), DEX-treated sedentary rats (DS), combined training control (CT), and DEX-treated trained rats (DT). During the last 14 d, rats were treated with DEX (50 μg/kg per body weight, per day, s.c.) or saline. Results: DEX increased PWV (+44% vs +5% m/s, for DS vs SC, p<0.001) and increased aortic COL 3 protein level (+75%) in DS. In addition, PWV was correlated with COL3 levels (r=0.682, p<0.0001). Aortic elastin and COL1 protein levels remained unchanged. On the other hand, the trained and treated groups showed lower PWV values (−27% m/s, p<0.001) vs DS and lower values of aortic and femoral COL3 compared with DS. Conclusion: As DEX is widely used in several situations, the clinical relevance of this study is that the maintenance of good physical capacity throughout life can be crucial to alleviate some of its side effects, such as arterial stiffness. [ABSTRACT FROM AUTHOR]

AbstractObjectveMaterials and MethodsResultsConclusionThe purpose of the research was to investigate the effects of aerobic training on renal function, oxidative stress, intrarenal renin–angiotensin system, and mortality of hypertensive and diabetic (SHR-STZ) rats.Blood pressure, creatinine, urea levels, urinary glucose, urine volume, and protein excretion were reduced in trained SHR-STZ rats.Aerobic training not only attenuated oxidative stress but also elevated the activity of antioxidant enzymes in the kid′ney of SHR-STZ rats. Training increased intrarenal levels of angiotensin-converting enzymes (ACE and ACE2) as well as the neprilysin (NEP) activity, along with decreased intrarenal angiotensin II (Ang II) levels. Aerobic training significantly improved the survival of STZ-SHR rats.The protective role of aerobic training was associated with improvements in the renal antioxidative capacity, reduced urinary protein excretion along with reduced intrarenal Ang II and increased NEP activity. These findings might reflect a better survival under the combined pathological conditions, hypertension, and diabetes. [ABSTRACT FROM AUTHOR]

Aerobic training (AT), an effective form of cardiac rehabilitation, has been shown to be beneficial for cardiac repair and remodeling after myocardial infarction (MI). The p300/CBP‐associated factor (PCAF) is one of the most important lysine acetyltransferases and is involved in various biological processes. However, the role of PCAF in AT and AT‐mediated cardiac remodeling post‐MI has not been determined. Here, we found that the PCAF protein level was significantly increased after MI, while AT blocked the increase in PCAF. AT markedly improved cardiac remodeling in mice after MI by reducing endoplasmic reticulum stress (ERS). In vivo, similar to AT, pharmacological inhibition of PCAF by Embelin improved cardiac recovery and attenuated ERS in MI mice. Furthermore, we observed that both IGF‐1, a simulated exercise environment, and Embelin protected from H2O2‐induced cardiomyocyte injury, while PCAF overexpression by viruses or the sirtuin inhibitor nicotinamide eliminated the protective effect of IGF‐1 in H9C2 cells. Thus, our data indicate that maintaining low PCAF levels plays an essential role in AT‐mediated cardiac protection, and PCAF inhibition represents a promising therapeutic target for attenuating cardiac remodeling after MI. [ABSTRACT FROM AUTHOR]

Background and Aims: Aging causes changes in health status, including endothelial dysfunction, angiogenesis disorder, and an increase in the prevalence of diseases. Due to the growing trend of aging in the world, it is important to prevent the occurrence of related problems in this period. Sports activity can be a positive factor in stimulating the angiogenesis process in physiological conditions and even in pathological conditions. This study aimed to investigate the effect of two types of aerobic and combined training (aerobic-strength) on the vascular endothelial growth factor (VEGF) and tissue inhibitor metalloproteinase (TIMP-1) factors in elderly men. Materials and Methods: In this quasi-experimental study, 30 elderly men with an average age of 62.36 ± 1.28 years were selected. These individuals were randomly and equally divided into three groups: aerobic, combined, and control based on body mass index and maximum oxygen consumption. The exercises were done for 8 weeks. Aerobic exercises were performed with 60-70% of heart rate reserve. The combined exercises were done with the same heart rate reserve as the aerobic exercise but with half the duration, and resistance exercise with 60-75% one-repetition maximum. Combined exercises consisted of both aerobic and strength exercises in one day, starting with strength training followed by aerobic exercise. Blood samples were collected to measure the serum levels of VEGF and TIMP-1 before the first and after the last session in a fasting state. The measurements were taken using the ELISA method. To compare the means within and between groups, analysis of covariance and paired t-tests were used with a significance level of P ≤ 0.05. Results: Aerobic exercises led to a significant increase in VEGF (P=0.001) and a significant decrease in TIMP-1 (P=0.001) compared to the control group. Combined exercises also caused a significant increase in VEGF (P=0.001) and a significant decrease in TIMP-1 (P=0.001) compared to the control group. According to post-test results, VEGF significantly increased, and TIMP-1 significantly decreased in both aerobic and combined groups compared to pre-test results. Conclusion: Aerobic and combined exercise caused an increase in VEGF, a decrease in TIMP-1, and an improvement in the angiogenesis process in the elderly men. [ABSTRACT FROM AUTHOR]

Background and Objectives Spexin is a peptide related to energy homeostasis that affects pancreatic and insulin function. The aim of the present study was to determine the effect of moderate intensity continuous aerobic training on body composition, serum spexin and insulin resistance in inactive obese women. Subjects and Methods In this quasi-experimental research, 24 inactive obese women were selected purposefully and were randomly divided into training (n=12) and control (n=12) groups. Participants engaged in a 10-week exercise program involving three weekly sessions of moderate-intensity continuous aerobic running. Body composition, insulin resistance and serum spexin levels were assessed under fasting conditions pre- and postintervention. Statistical analysis involved paired sample t-tests and covariance analysis. Results The training group demonstrated significant increases in serum spexin levels (P < 0.001, F = 43.678) and significant decreases in insulin resistance (P < 0.001, F = 30.542), body mass index (P < 0.001, F = 40.298), and waist circumference (P < 0.001, F = 384.939) compared to the control group. Conclusion Moderate-intensity aerobic exercise decreased insulin resistance, possibly through improvements in body composition and increased serum spexin levels. [ABSTRACT FROM AUTHOR]

This study was conducted to investigate the effects of 12 weeks of aerobic exercise (AT) and saffron supplementation on hemostasis, inflammatory markers, and insulin resistance in obese women diagnosed with type 2 diabetes (T2D). A total of 44 women with T2D (mean age: 54.12 ± 5.63 years, mean BMI: 31.15 ± 1.50 kg/m2, HbA1c: 85 ± 4.2 mmol/mol) were included in a randomized, double‐blind, placebo‐controlled study. We were randomly assigned to one of four groups (n = 11 per group): saffron + training (ST), placebo + training (PT), saffron supplement (SS), and placebo (P). The ST and PT groups completed 12 weeks of AT (three sessions per week of mild to moderate intensity). The ST and SS groups were administered a daily dose of 200 mg of saffron powder for 12 weeks. Fasting blood samples were collected 48 h before the first AT session and/or nutritional supplementation and 48 h after the last AT session and/or nutritional supplementation. Post‐evaluation, homeostatic model assessment of insulin resistance value (HOMA‐IR, p < 0.001) and serum levels of glucose (p < 0.001), fibrinogen (FIB, p < 0.001), homocysteine (HCY, p < 0.001), interleukin‐6 (IL‐6, p < 0.001), and tumor necrosis factor α (TNFα, p < 0.001) showed significant reduction in the ST, PT, and SS groups compared to the P group (p < 0.05). In particular, the ST group showed a more significant reduction in all variables compared to the PT and SS groups (p < 0.05). Our results suggest that a 12‐week intervention with AT and saffron supplementation can independently improve markers related to hemostasis, inflammation, and insulin resistance. However, their combination showed the greatest effectiveness on the above markers. Highlights: Type 2 diabetes can disturb hemostasis and induce inflammation.12 weeks of aerobic training (AT) and saffron supplementation can independently improve hemostasis, inflammation, and insulin resistance.The combination of 12 weeks of AT and saffron supplementation showed the greatest effectiveness on hemostasis, inflammation, and insulin resistance. [ABSTRACT FROM AUTHOR]

The existing paper aims to gauge the effect of aerobic training on the quality of agility of football players. The main objective of the paper was to articulate the effect of aerobic training on male football player's agility. Thirty players were chosen from two schools in Dera Ismail Khan, Khyber Pakhtunkhwa, Pakistan, and were equally distributed into two groups same in number. Both groups had 15 players in controlled and experimental. The first group underwent aerobic training three times a week over eight weeks, while the second group, serving as the control, continued with their regular activities without any additional training.The control group was placed in one group and give aerobic exercise Three time a week for eight weeks. A shuttle run test was used to assess each participant's agility both before and after the training session. The male football player's agility was greaterly enhanced by aerobic exercise. It was also concluded that regular aerobic exercise can help male football players became more agile. It was suggested that aerobic exercise incorporating into training regimen may enhance the agility of the football players. It was also suggested that providing of paper facilities of the training may improve the agility power of the players. [ABSTRACT FROM AUTHOR]

Introduction: Egypt lacks awareness regarding the positive influence of reflexology along with aerobic training (AT) on the quality of life (QoL) of patients with hypertension (HTN). Objective: We aim to determine reflexology and AT effects on the insomnia severity index (ISI) and QoL of HTN patients. Methods: This study enrolled 40 HTN female patients aged 35-45 years who were equally divided into groups A and B. Groups A and B participants were provided with medications and peddling training, while Group B participants also received reflexology. The treatment protocol consisted of an eight-week program with three sessions per week. After the fourweek treatment protocol, a post-evaluation (post-1) was conducted and was repeated after another four-week treatment (post-2). The participants underwent assessment for systolic and diastolic blood pressure, ISI, and a 36-item short-form survey (SF-36), a general QoL measure, pre- and post-treatment. Results: The results revealed significant discrepancies in the assessed variable between both groups pre- and post-treatment (post-1/2). When comparing the post-treatment values (post- 1/2) of the evaluated variable between groups A and B, incorporating reflexology and AT, such as peddling training, into the physical treatment program is recommended. Conclusion: The study highlights the positive impact of reflexology and AT on the QoL and ISI of female HTN patients, recommending their incorporation into treatment programs. [ABSTRACT FROM AUTHOR]

Introduction: Breast cancer is the most common cancer in women with a 5-year survival over 90%. However, anthracycline-based chemotherapy causes significant cardiotoxicity often requiring discontinuation of chemotherapeutic regimen among breast cancer survivors. We conducted a systematic review and meta-analysis to evaluate the efficacy of exercise training in mitigating anthracycline-related cardiotoxicity among women with breast cancer. Methods: We searched PubMed, Embase, Cochrane Central Register of Controlled Trials, Web of Science, and Scopus databases. The outcomes of interest were left ventricular ejection fraction (LVEF), global longitudinal strain (GLS), early to atrial filling velocity (E/A) ratio, maximal oxygen consumption (VO2 max), and cardiac output (CO). We used the Cochrane risk-of-bias tool for randomized trials (RoB 2) to assess the risk of bias in individual studies. Results: We identified a total of 596 articles with 5 trials included in the final analysis. Exercise training was associated with an increase in VO2 max compared with no exercise training (mean difference, 3.95 [95% CI, 0.63–7.26]; I2 = 99.68%). Other cardiovascular outcomes such as LVEF (mean difference, 1.76 [95% CI, −1.95 to 5.46]; I2 = 99.44%), GLS (mean difference, 0.30 [95% CI, −0.49 to 1.10]; I2 = 96.63%), E/A ratio (mean difference, 0.05 [95% CI, −0.05 to 0.15]; I2 = 94.16%), and CO (mean difference, 0.38 [95% CI, −0.91 to 1.66]; I2 = 99.73%) are similar between patients who underwent exercise training and those who did not. Conclusions: Exercise was associated with an improvement in maximal oxygen uptake among women with breast cancer receiving anthracycline-based chemotherapy. [ABSTRACT FROM AUTHOR]

Ferroptosis is a form of programmed cell death that plays a significant role in causing several diseases such as heart attack and heart failure, through alterations in fat, amino acid, and iron metabolism. Comprehending the regulatory mechanisms of ferroptosis signaling is critical because it has a considerable effect on the elderly's mortality. Conversely, age-related changes in substrate metabolism and metabolite levels are recognized to give rise to obesity. Furthermore, research has proposed that aging and obesity-related changes in substrate metabolism may aggravate ferroptosis. The suppression of ferroptosis holds potential as a successful therapeutic approach for managing different diseases, including sarcopenia, cardiovascular diseases, and central nervous system diseases. However, the pathologic and biological mechanisms behind the function of ferroptosis are not fully comprehended yet. Physical activity could affect lipid, amino acid, and iron metabolism to modulate ferroptosis. The aim of this study is to showcase the current understanding of the molecular mechanisms leading to ferroptosis and discuss the role of aging and physical activity in this phenomenon. [ABSTRACT FROM AUTHOR]

The primary aim of the present investigation was to compare the acute physiological and perceptual responses between two modes of interval training using a randomized crossover design. More specifically, eleven young adult participants (23 ± 4 years, 77 ± 13 kg, 178 ± 7 cm) performed two protocols: one composed of whole-body calisthenics exercises and another on a cycle ergometer. Both protocols encompassed eight 20 s bouts at intensities equivalent to all-out (HIIT-WB) and 170% of the maximal power output (HIIT-C), respectively, interspersed with 10 s of passive rest. The peak and average heart rate, the rating of perceived effort, and blood lactate, creatine kinase, and lactate dehydrogenase concentrations were measured. Aside from blood lactate (HIIT-WB = 9.4 ± 1.8 mmo/L; HIIT-C = 12.5 ± 2.5 mmol/L, p < 0.05) and the rating of perceived exertion (HIIT-WB = 8.8 ± 0.9; HIIT-C = 9.6 ± 0.5, p < 0.05), physiological responses did not significantly differ between protocols (all p > 0.05), with high average heart rate values (HIIT-WB = 86 ± 6% HRmax; HIIT-C = 87 ± 4% HRmax) and a low magnitude of muscle damage, as inferred by CK and LDH concentrations (HIIT-WB = 205.9 ± 56.3 and 203.5 ± 72.4 U/L; HIIT-C = 234.5 ± 77.1 and 155.1 ± 65.3 U/L), respectively. It can be concluded that both protocols elicit vigorous heart rate responses and a low magnitude of muscle damage and, therefore, appear as viable alternatives to improve aerobic fitness. The inclusion of a whole-body HIIT protocol may be an interesting alternative for training prescription in relation to more common interval training protocols. [ABSTRACT FROM AUTHOR]

Background and Aim: Physical activity and using herbal supplements are essential for improving health, prevention and reduction of the complications of diseases caused by obesity. A recent study examined the effects of combining garlic and stevia extract with aerobic training on the structural changes of adipose tissue in obese rats. Materials and Methods: The study involved 35 obese male Wistar rats divided into seven groups of five: healthy control, obese control, obese + garlic, obese + stevia, obese + aerobic training, obese + garlic + aerobic training, and obese + stevia + aerobic training. Obesity was induced over 12 weeks, followed by aerobic training on a treadmill and consumption of garlic and stevia extract at a dose of 250 mg/kg dissolved in drinking water for eight weeks. Qualitative examination of structural changes in adipose tissue was conducted using light microscopy, and body weight was analyzed using one-way ANOVA at a significance level of p < 0.05. Results: Obesity leads to pathological alterations in white adipose tissue, such as cell enlargement, membrane disintegration, and the presence of small and indistinct nuclei, as well as mild pathological changes in brown adipose tissue, including the formation of numerous fat droplets. In the obese group, the consumption of garlic led to a reduction of changes in white adipose tissue to a minimum and zero changes in brown adipose tissue, although some inflammation and hyperemia were observed in adipose tissue. Meanwhile, consuming stevia resulted in minimum changes in white adipose cells, with no observed change in brown adipose tissue. When aerobic training was performed, as well as aerobic training in combination with garlic extract, all changes induced by obesity vanished. Conversely, aerobic training in combination with stevia led to minor alterations in white adipose tissue. Conclusion: Engaging in aerobic exercise, either on its own or in conjunction with garlic extract, has been shown to enhance the structural changes of adipose tissue in obese rats, regardless of weight reduction. [ABSTRACT FROM AUTHOR]

Introduction: Increased nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) signaling in neuroblastoma cells may represent an autocrine system to support cancer growth, invasion, and metastasis. Therefore, this research aimed to assess the simultaneous effect of aerobic exercise and nano curcumin supplementation on the expression of BDNF and NGF genes in rats with brain tumors. Material & Methods: A total of 35 male Wistar rats were randomly assigned to seven groups of five: healthy base control, healthy control of 4 weeks, base cancer control, four weeks of cancer control, cancer+nanocolumns, cancer+aerobic, and cancer exercise+aerobic exercise+nanocolumns. After injecting cancer cells into the mice's forehead cortex, with 80 mg/kg supplement gauges for 28 days, five days a week, enter the main aerobic exercise program on the rotating tape for four weeks, three days a week. At 18 m/min, they were 25-40 minutes. In the end, the mice were sacrificed, and data were collected. Results: The expression of the BDNF gene in the training+nano curcumin group was significantly decreased compared to the baseline cancer control and 4-week cancer (P<0.05). Moreover, the expression of the NGF gene in the exercise group showed a significant decrease compared to the baseline cancer control and 4-week cancer (P<0.05). Nonetheless, no significant difference was observed in the nano curcumin group and nanocurcumin +exercise (P>0.05). Discussion & Conclusion: It seems that aerobic exercise along with nanocurcumin can possibly increase neurogenesis in rats with brain cancer by reducing BDNF and NGF gene expression through receptors. [ABSTRACT FROM AUTHOR]

IntroductionPhysical training induces iron status impairment in athletic females in the short term and over prolonged periods. Nevertheless, the existing literature lacks a comprehensive evaluation of the differential impacts of aerobic vs. anaerobic training on hematological indices and iron status among adolescent female athletes. The aim of this study was to assess the hematological factors and iron status in aerobic vs. anaerobic training in athletic females.MethodsThis observational, cross-sectional study recruited twenty-five adolescent athletic females; thirteen of them participated in an aerobic sport (long-distance running), while twelve of them participated in an anaerobic sport (broad jumping). Hematological factors were assessed by analyzing blood concentrations of hemoglobin (Hb), hematocrit (Hct), red blood cell (RBC) count, mean corpuscular volume (MCV), and mean corpuscular hemoglobin concentration (MCHC), while the iron status assessment was conducted through evaluating levels of serum transferrin and serum ferritin.ResultsAthletic females who participated in the aerobic sport showed significantly lower Hb (MD −0.84; 95% CI −1.63: −0.04; p = 0.041), Hct (MD −5.49; 95% CI −7.86: −3.12; p = 0.0001), RBC count (MD −0.37; 95% CI −0.57: −0.17; p = 0.001), and MCV (MD −5.15; 95% CI −9.41: −0.89; p = 0.020), as well as significantly higher MCHC (MD 2.99; 95% CI 2.18: 3.79; p = 0.0001) and serum transferrin (MD 46.77; 95% CI 10.95: 82.59; p = 0.013) than athletic females who participated in the anaerobic sport. However, there was an insignificant difference in serum ferritin levels (MD −3.18; 95% CI −11.49: 5.13; p = 0.437) between both groups.ConclusionExcept for the ferritin level that exhibited an insignificant difference between aerobic and anaerobic training, aerobic training was associated with a worse impact on the hematological factors and iron status than anaerobic training in adolescent athletic females.

Background Black compared with White adults have a higher risk for left‐ventricular hypertrophy and heart failure possibly due to the early onset of alterations in ventricular–vascular coupling (ie, arterial [Ea] to ventricular elastance [Ees] ratio) and wasted pressure effort (Ew). Aerobic training preserves the coupling ratio (Ea/Ees) and attenuates Ew, but whether this applies to Black adults is unknown. We hypothesized that Black rather than White adults would have greater training‐induced improvements in the Ea/Ees and Ew. Methods and Results Fifty‐four young adults with normal blood pressure (Black=24 [58% female]; White=30 [47% female], mean=24 years; SD=5 years) completed an 8‐week aerobic training (3 times/week, 65%–85% peak oxygen uptake). Ea/Ees was estimated via echocardiography and scaled to body surface area, and the Ew was estimated from pulse contour analysis. Black adults had lower Ea/Ees (difference (d)=0.49 [95% CI, 0.14–0.84 mm Hg/mL], P=0.007) and higher Ew (d=1127 [95% CI, 104–2007 dyne cm−2 s], P=0.005). Both groups exhibited similar (race‐by‐training interaction, P=0.986) training‐induced reductions in scaled Ea (d=−0.11 [95% CI, −0.18 to −0.04 mm Hg/mL], P

Background Concurrent training (CT) is emerging as a practical and effective approach to enhance body composition, cardiovascular function, and muscle mass, thereby elevating overall individual health. This study aims to systematically investigate the effects of short- and long-term concurrent aerobic and resistance training on circulating irisin levels in overweight or obese individuals. Methodology The electronic databases, including China National Knowledge Infrastructure, PubMed, Embase, Wan Fang Database, and Web of Science, were systematically searched for articles on “concurrent training” and “irisin” published from their inception to 30 November 2023. The pooled effect size was determined using standardized mean difference (SMD) and corresponding 95% confidence intervals (CIs). The study protocol received registration with the International Prospective Register of Systematic Reviews (CRD42023494163). Results All nine studies, encompassing a total of 264 participants, were randomized controlled trials and met the eligibility criteria. Results indicate that short- and long-term concurrent training moderately increased circulating irisin levels compared to the control group (SMD = 0.56, 95% CI [0.33–0.80], p = 0.00; I2 = 36.6%, heterogeneity p = 0.106). Subgroup analyses revealed that both equal to or less than 10 weeks (SMD = 0.78, 95% CI [0.18–1.37], p = 0.01; I2 = 62.3%, heterogeneity p = 0.03) and more than 10 weeks (SMD = 0.45, 95% CI [0.14–0.76], p = 0.00; I2 = 0%, heterogeneity p = 0.54) of concurrent training significantly increased circulating irisin levels in overweight or obese individuals. There were no significant between-group differences (I2 = 0%, p = 0.34). Additionally, concurrent training significantly increased irisin levels in overweight or obese participants (SMD = 1.06, 95% CI [0.34–1.78], p = 0.00; I2 = 50.6%, heterogeneity p = 0.13) and in type 2 diabetes patients (SMD = 0.70, 95% CI [0.30–1.10], p = 0.00; I2 = 0%, heterogeneity p = 0.99). However, no significant effect was observed in patients with metabolic syndrome (SMD = 0.21, 95% CI [−0.25–0.68], p = 0.37; I2 = 38.7%, heterogeneity p = 0.18). There were significant between-group differences (I2 = 53.9%, p = 0.11). Lastly, concurrent training significantly increased circulating irisin levels in overweight or obese individuals aged 45-60 years (SMD = 0.56, 95% CI [0.25–0.86], p = 0.00; I2 = 6.5%, heterogeneity p = 0.38), and a significant increase in irisin levels was observed 12 h post-intervention (SMD = 0.70, 95% CI [0.35–1.05], p = 0.00; I2 = 0%, heterogeneity p = 0.74). However, none of the above categorical variables showed significant between-group differences. Conclusions Short- and long-term concurrent training can effectively improve circulating irisin levels in overweight or obese individuals. However, the effects of short- and long-term concurrent training should consider the participants’ health status, age, and the timing of post-exercise measurements to maximize health benefits.

The article "Cycling away from cancer: can aerobic training enhance interleukin-15 response to acute exercise?" published in the Journal of Physiology discusses the impact of physical activity on cancer development and recurrence, focusing on interleukin-15 (IL-15) as a potential anti-oncogenic agent. The study found that acute exercise increased circulating IL-15 concentrations, regardless of persistent exercise training. The research involved cancer survivors undergoing high-intensity interval training and highlighted the importance of exercise in modulating IL-15 and other inflammatory markers. The study suggests that aerobic exercise at high intensity can lead to significant IL-15 release in cancer survivors, but further research is needed to determine the optimal exercise modality. [Extracted from the article]

Background and purpose: Atrophy of the skeletal system caused by spinal cord injury (SCI) can cause secondary systemic metabolic dysfunction, such as glucose intolerance, type 2 diabetes, and insulin resistance. On the other hand, Sirtun1 (SIRT1) and Peroxisome Proliferator-Activated Receptor-Gamma Coactivator-1alpha (PGC-1α) are known factors and related proteins involved in skeletal muscle atrophy. Therefore, the present study aimed to investigate the effect of aerobic training with resveratrol consumption on SIRT1 and PGC-1α levels in the gastrocnemius muscles of rats after spinal cord injury. Materials and methods: 36 male Wistar rats aged eight weeks were randomly placed in 4 groups including control, resveratrol, training, and resveratrol+training (each group n=9). After anesthesia, an incision was made in the midline of the back and over the vertebral ridges. The muscles and lamina of the T9 vertebra were removed without damaging the dura mater, Spinal cord injury was caused by dropping a ten-gram weight from a height of 25 mm on the spinal cord in the T10 segment. After confirmation of SCI, a Resveratrol supplement with a dose of 10 mg/kg was injected intraperitoneally and daily (every morning for 4 weeks), and the rats of other groups were injected with the same amount of saline. The aerobic training was carried out with the help of the weight support system for 4 weeks, 5 sessions per week, each session was 58 minutes and the intensity was 20 m/min. 48 hours after the last training session, the gastrocnemius muscle of right leg of all rats was removed. The SIRT1 and PGC-1α levels in the gastrocnemius muscle were measured by the ELISA method. To analyze the data, one-way analysis of variance and LSD post hoc tests were used at the significance level of P

Background and Aim: Parkinson's disease is a prevalent neurodegenerative disorder characterized by the degeneration of dopaminergic neurons and the presence of catalepsy. This study aimed to investigate the effects of 12 weeks of aerobic training and food restriction on dopaminergic and catalepsy neurons in the brain tissue of Parkinson's disease model of rats. Methods: In this experimental study, 40 male Wistar rats aged 2-3 months were randomly divided into five groups (n=8): healthy control (C), Parkinson's disease model (P), Parkinson's disease model + aerobic training (P+T), Parkinson's disease model + food restriction (P+FR), and Parkinson's disease model + aerobic training + food restriction (P+T+FR). The aerobic training regimen consisted of three months with five sessions per week at an intensity of 75-80% of maximum oxygen consumption. The food restriction group received approximately 11 grams of food daily. Catalepsy was assessed using the rod test, while dopaminergic neurons were quantified through brain sectioning and microscopic counting. Results: The P+T+FR group exhibited a significant increase in dopaminergic neuron count compared to the C, P, P+T, and P+FR groups (P=0.001). Furthermore, a significant reduction in catalepsy was observed in the P+T+RF group compared to the P group (P=0.001). Conclusion: The combination of three months of aerobic training and food restriction resulted in improvements in dopaminergic neuron count and reduced catalepsy in a rat model of Parkinson's disease. These findings suggest that aerobic training and food restriction could serve as potential complementary interventions for Parkinson's disease treatment, alongside pharmacological approaches, warranting further investigation in this area.

Abstract Dysregulation of key transcription factors involved in hepatic energy metabolism, such as peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1α) and liver X receptor alpha (LXRα), has been observed in T2DM. The present study aims to investigate the effects of aerobic training and vitamin D supplementation on liver enzyme levels and the levels of PGC-1α and LXRα proteins in hepatocytes, in a rat model of T2DM. The study involved 56 male Wistar rats, divided into two groups: one was non-diabetic and acted as a control group (n = 8), and the other had induced diabetes (n = 48). The diabetic rats were then split into six subgroups: two groups received high or moderate doses of vitamin D and aerobic training (D + AT + HD and D + AT + MD); two groups received high or moderate doses of vitamin D alone (D + HD and D + MD); one group underwent aerobic training with vehicle (sesame oil; D + AT + oil), and one group was a diabetic control receiving only sesame oil (oil-receiving). The D + AT + HD and D + HD groups received 10,000 IU of vitamin D, while the D + AT + MD and D + MD groups received 5000 IU of vitamin D once a week by injection. The D + AT + oil group and the sham group received sesame oil. After eight weeks of treatment, body weight, BMI, food intake, serum insulin, glucose, 25-hydroxyvitamin D, ALT, AST, and visceral fat were measured. The levels of PGC-1α and LXRα proteins in the liver was assessed by western blotting. Statistical analysis was performed using the paired t-test, one-way analysis of variance (ANOVA), and the Tukey post hoc test at a significance level of P

Myotonic dystrophy Type 1 (DM1) is a neuromuscular disease characterized by multisystemic involvement including a progressive loss of muscle mass and strength. Further investigation on the effect of exercise in adults with DM1 is needed to incorporate impactful recent findings to better understand the utility of exercise as an intervention. This review aims to summarize and appraise the literature on the effects of aerobic and strength training on clinical and physiological variables in adults with DM1. Six online databases (PubMed, Scopus, Web of Science, CINAHL, EMBASE, and CENTRAL) will be searched using appropriate search terms. Two reviewers will independently screen the relevant studies and extract the data from the selected articles. The methodological quality of the studies included will be assessed using the Joanna Briggs Critical Appraisal checklist. A meta-analysis will be performed if appropriate. This systematic review and meta-analysis will summarize, synthesize, and appraise evidence on the effect of aerobic and strength training on clinical and physiological variables in adults with DM1. The findings of this review will help in clinical decision-making and guide future researchers working with this patient population.

ABSTRACTPhysical activity is a first-line treatment for polycystic ovary syndrome (PCOS). Resistance or aerobic exercise improves metabolic complications, reproductive outcomes, and quality of life in PCOS. DNA methylation reprogramming during exercise may be the major modifier behind these changes. We sought to evaluate genome-wide DNA methylation changes after supervised resistance and aerobic exercise in women with PCOS. Exercises were performed in 56 women with PCOS (resistance, n = 30; aerobic, n = 26), for 16 weeks (wks), three times per week, in 50-minute to one-hour sessions. Anthropometric indices and hormonal and metabolic parameters were measured before and after training. Genome-wide leukocyte DNA methylation was analysed by Infinium Human MethylationEPIC 850K BeadChip microarrays (Illumina). Both resistance and aerobic exercise improved anthropometric indices, metabolic dysfunction, and hyperandrogenism in PCOS after the training programme, but no differences were observed between the two exercises. Resistance and aerobic exercise increased genome-wide DNA methylation, although resistance changed every category in the CpG island context (islands, shores, shelve, and open sea), whereas aerobic exercise altered CpG shores and the open sea. Using a stringent FDR (>40), 6 significantly differentially methylated regions (DMRs) were observed in the resistance exercise cohort and 14 DRMs in the aerobic cohort, all of which were hypermethylated. The increase in genome-wide DNA methylation may be related to the metabolic and hormonal changes observed in PCOS after resistance and aerobic exercise. Since the mammalian genome is hypermethylated globally to prevent genomic instability and ageing, resistance and aerobic exercise may promote health and longevity through environmentally induced epigenetic changes.

Introduction: Insulin resistance (IR) is known as the most important cause of Liver Disorders, Which is associated with decreased expression of Peroxisome proliferator-Activated Receptor-alpha (PPAR-α) and increased expression of Sterol regulatory Element Binding Proteins (SREBP-1C) and Carbohydrate response element binding protein (CHREBP) in diabetic type 2 male rats. The aim of this study was to evaluate the effect of eight weeks of aerobic exercise on hepatic PPAR-α, SREBP-1C and CHREBP expression and IR in n diabetic type 2 rat. Method: In this experimental study, 27 male Wistar mice were randomly divided into three groups of healthy control, diabetic control and diabetic exercise. Medium and progressive aerobic exercise protocol on the treadmill was performed and The trainings lasted 8 weeks and 5 days/week. At the end of the trainings PPAR-α, SREBP-1C and CHREBP expressions were examined via ELISA technique in the liver tissue. One-way Analysis of variance (ANOVA) test were used to compare the groups and the significance level was considered at p < 0.05. Findings: The post-hoc test results indicated a significant reduction in IR between the diabetic control group and aerobic training (P<0.05). Despite a notable increase in hepatic expression, it PPAR-α, SREBP-1C and CHREBP was statistically significant Conclusion: According to the results of this study, it seems that aerobic exercise for eight weeks improved IR in type 2 diabetic rats. There was a significant difference in the expression of liver proteins between the groups. [ABSTRACT FROM AUTHOR]

Objective: Increased intraindividual variability (IIV) of cognitive performance is a marker of cognitive decline in older adults. Whether computerized cognitive training (CCT) and aerobic exercise counteracts cognitive decline by reducing IIV is unknown. We investigated the effects of CCT with or without aerobic exercise on IIV in older adults. Methods: This was a secondary analysis of an 8-week randomized controlled trial. Older adults (aged 65–85 years) were randomized to CCT alone (n = 41), CCT with aerobic exercise (n = 41), or an active control group (n = 42). The CCT group trained using the Fit Brains® platform 3×/week for 1 hr (plus 3×/week of home-based training). The CCT with aerobic exercise group received 15 min of walking plus 45 min of Fit Brains® 3×/week (plus 3×/week of home-based training). The control group received sham exercise and cognitive training (3×/week for 1 hr). We computed reaction time IIV from the Dimensional Change Card Sort Test, Flanker Inhibitory Control and Attention Test (Flanker), and Pattern Comparison Processing Speed Test (PACPS). Results: Compared with the control group, IIV reduced in a processing speed task (PACPS) following CCT alone (mean difference [95% confidence interval]: −0.144 [−0.255 to −0.034], p < 0.01) and CCT with aerobic exercise (−0.113 [−0.225 to −0.001], p < 0.05). Attention (Flanker congruent) IIV was reduced only after CCT with aerobic exercise (−0.130 [−0.242 to −0.017], p < 0.05). Conclusions: A CCT program promoted cognitive health via reductions in IIV of cognitive performance and combining it with aerobic exercise may result in broader benefits. [ABSTRACT FROM AUTHOR]

Objectives: The objectives of this study were to assess the effect of 8 weeks of moderate-intensity aerobic training on permeability inflammatory indicators of matrix metalloproteinases (MMPs) and specific tissue inhibitors of MMPs in female migraineurs. Methods: Female migraineurs (n = 28, age 32 ± 6) were randomised into two groups: migraine with exercise training (EXE + Mig, n = 13) and migraine without exercise training (NON-EXE + Mig, n = 15). Matched healthy women were also recruited as a healthy control group (CON, n = 15). The EXE-Mig group performed 8 weeks of aerobic training. Pre and post intervention, serum matrix metalloproteinases (MMP-2 and 9) and specific tissue inhibitors of MMPs (TIMP-1 and 2) were measured. In addition, body composition indices and VO2max were determined. Results: Exercise training reduced serum MMP-9 in female migraineurs with between-group changes and a time x group interaction (p < 0.05). In addition, exercise training reduced the serum MMP-9/TIMP-1 ratio in female migraineurs with between-group changes and time x group interaction (p < 0.05). However, no training-induced effect was observed in serum TIMP-1, TIMP-2, MMP-2 contents (p > 0.05) and MMP-2/TIMP-2 ratio (p > 0.05). Finally, exercise training reduced body fat content, WHR and BMI, and improved VO2max (p < 0.01). Conclusions: Our results demonstrated beneficial effects of aerobic exercise training on some circulatory inflammation factors (MMP9, MMP-9/TIMP-1) and some health indicators in female migraineurs, suggesting that such training can be employed as a non-pharmacological therapeutic method. [ABSTRACT FROM AUTHOR]

Background and purpose: Atrophy of the skeletal system caused by spinal cord injury (SCI) can cause secondary systemic metabolic dysfunction, such as glucose intolerance, type 2 diabetes, and insulin resistance. On the other hand, Sirtun1 (SIRT1) and Peroxisome Proliferator-Activated Receptor-Gamma Coactivator-1alpha (PGC-1α) are known factors and related proteins involved in skeletal muscle atrophy. Therefore, the present study aimed to investigate the effect of aerobic training with resveratrol consumption on SIRT1 and PGC-1α levels in the gastrocnemius muscles of rats after spinal cord injury. Materials and methods: 36 male Wistar rats aged eight weeks were randomly placed in 4 groups including control, resveratrol, training, and resveratrol+training (each group n=9). After anesthesia, an incision was made in the midline of the back and over the vertebral ridges. The muscles and lamina of the T9 vertebra were removed without damaging the dura mater, Spinal cord injury was caused by dropping a ten-gram weight from a height of 25 mm on the spinal cord in the T10 segment. After confirmation of SCI, a Resveratrol supplement with a dose of 10 mg/kg was injected intraperitoneally and daily (every morning for 4 weeks), and the rats of other groups were injected with the same amount of saline. The aerobic training was carried out with the help of the weight support system for 4 weeks, 5 sessions per week, each session was 58 minutes and the intensity was 20 m/min. 48 hours after the last training session, the gastrocnemius muscle of right leg of all rats was removed. The SIRT1 and PGC-1α levels in the gastrocnemius muscle were measured by the ELISA method. To analyze the data, one-way analysis of variance and LSD post hoc tests were used at the significance level of P<0.05. Results: SIRT1 levels in the gastrocnemius muscle of resveratrol and resveratrol+training groups were significantly higher than the control group (P-value respectively 0.023 and 0.007), but despite the increase in the level of this index in the training group compared to the control group, no significant difference was observed (P=0.399). SIRT1 levels in gastrocnemius muscle of resveratrol+training groups were significantly higher than training group (P=0.038). PGC-1α levels in gastrocnemius muscle of training and resveratrol+ training groups were significantly higher than control group (P-value respectively 0.024 and 0.007), but despite the increase in the level of this index in the resveratrol group compared to the control group, no significant difference was observed (P=0.449). PGC-1α levels in gastrocnemius muscle of resveratrol+training groups were significantly higher than reveratrol group (P=0.023). Conclusion: These results show the positive effect of resveratrol consumption, on SIRT1 level, as well as aerobic exercise on PGC-1α level of the biceps muscle in rats with SCI. It has been pointed out that the increase in SIRT1 expression and the subsequent increase in PGC-1α leads to an increase in the number of myonuclei, which improves the recovery process after injury and plays an active role in muscle hypertrophy by upregulating and reducing catabolic processes. herefore, it appears that a combination of aerobic training and resveratrol supplementation can mitigate muscle atrophy caused by spinal cord injury in muscles below the level of injury by influencing the levels of muscle SIRT1 and PGC-1α. [ABSTRACT FROM AUTHOR]

The aim of this study is to evaluate the effect of aerobic training intervention on body components in obese, overweight and normal weight children aged 10-12 years. Methods: quasi experimental pretest / posttest study design was used. The research sample was deliberately chosen from the primary school students of the ninth Kuwait School for Boys for the academic year (2022-2023), whose number is (56) students, with (10) obese children and (23) overweight children And ( 23) normal children. Paired independent t test Analysis was used to test the effect of the intervention between pre- and post-training. Results: The intervention significantly improved body component measurements in children with obesity or overweight when the pre-test and post-test values were compared in the research; BMI (p<0.001); Fat M(kg) (p<0.001); It was determined that there was a statistically significant difference in TR Fat M (p<0.001). However, in the data below, he concluded that there was no statistically significant difference between the variables;TBW(L) (p>0.05); PMM(%) (p>0.05); TR FFM (p>0.05); TR PMM (p>0.05). Conclusions: aerobic training made a significant difference in body component indices among children aged 10-12 years with obesity or overweight. Programmed aerobic training interventions can be used to improve some body component indices in obese and overweight children. [ABSTRACT FROM AUTHOR]