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Copyright of Chinese Journal of Bioprocess Engineering is the property of Chinese Journal of Bioprocess Engineering Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

The new and rapid advancement in the complexity of biologics drug discovery has been driven by a deeper understanding of biological systems combined with innovative new therapeutic modalities, paving the way to breakthrough therapies for previously intractable diseases. These exciting times in biomedical innovation require the development of novel technologies to facilitate the sophisticated, multifaceted, high-paced workflows necessary to support modern large molecule drug discovery. A high-level aspiration is a true integration of "lab-on-a-chip" methods that vastly miniaturize cellulmical experiments could transform the speed, cost, and success of multiple workstreams in biologics development. Several microscale bioprocess technologies have been established that incrementally address these needs, yet each is inflexibly designed for a very specific process thus limiting an integrated holistic application. A more fully integrated nanoscale approach that incorporates manipulation, culture, analytics, and traceable digital record keeping of thousands of single cells in a relevant nanoenvironment would be a transformative technology capable of keeping pace with today's rapid and complex drug discovery demands. The recent advent of optical manipulation of cells using light-induced electrokinetics with micro- and nanoscale cell culture is poised to revolutionize both fundamental and applied biological research. In this review, we summarize the current state of the art for optical manipulation techniques and discuss emerging biological applications of this technology. In particular, we focus on promising prospects for drug discovery workflows, including antibody discovery, bioassay development, antibody engineering, and cell line development, which are enabled by the automation and industrialization of an integrated optoelectronic single-cell manipulation and culture platform. Continued development of such platforms will be well positioned to overcome many of the challenges currently associated with fragmented, low-throughput bioprocess workflows in biopharma and life science research.

The effective regeneration of bone/cartilage defects remains a significant clinical challenge, causing irreversible damage to millions annually.Conventional therapies such as autologous or artificial bone grafting often yield unsatisfactory outcomes, emphasizing the urgent need for innovative treatment methods. Biomaterial-based strategies, including hydrogels and active scaffolds, have shown potential in promoting bone/cartilage regeneration. Among them, injectable hydrogels have garnered substantial attention in recent years on account of their minimal invasiveness, shape adaptation, and controlled spatiotemporal release. This review systematically discusses the synthesis of injectable hydrogels, bioinspired approaches-covering microenvironment, structural, compositional, and bioactive component-inspired strategies-and their applications in various bone/cartilage disease models, highlighting bone/cartilage regeneration from an innovative perspective of bioinspired design. Taken together, bioinspired injectable hydrogels offer promising and feasible solutions for promoting bone/cartilage regeneration, ultimately laying the foundations for clinical applications. Furthermore, insights into further prospective directions for AI in injectable hydrogels screening and organoid construction are provided., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024. Published by Elsevier B.V.)

The authors present some compelling arguments seeking to demonstrate the importance and the need of a close interrelation and cooperation between biotechnology and new global medical concept One Health; at the beginning, the concept was based on the idea of the existence of a single medicine including both Comparative Medicine, which connects the human medicine to veterinary one, and Zoonoses and Comparative Oncology. Over time, including a significance contribution of Romanian Association, the concept was developed by integrating other new areas: Environmental Medicine, Food and Nutrition Medicine and Occupational Medicine. These six major commands formed, in our opinion, a globalizing interdependent structure that symbolically could be found in the hexagonal pattern that is Romanian One Health Association logo. Clearly, in this new concept a component that is found in all the mentioned areas is biotechnology that has and will have a major contribution in the development of One Health structure using its latest concepts and specific methodologies. We believe that advanced biotechnology is an effective "locomotive" of the socio- medical progress in all mentioned areas; As result, biotechnology, especially in its present and revolutionary forms must become an effective and active partner of this new medical global concept One Health. [ABSTRACT FROM AUTHOR]

Nowadays, meat adulteration constitutes an important problem in Egypt. Adulteration causes many problems that need to be considered as economic issues arising from replacement of high commercial value meat species with cheaper or undesired meats, religious issues as pork meat prohibited for Muslims and allergic reactions arising from consumption of some special meats as equine meat species and others. The current study includes a surveillance study aimed to detect the adulteration of beef and poultry meat products with equine and or pork meat species in Damanhur city, El Behera Governorate, Egypt. Over a limited period of one year from February, 2015 to February, 2016, A total of 156 samples of meat and chicken products were collected and divided into two groups; Group (A) includes 96 packaged high brands of three meat processing plants including beef luncheon, burger and kofta (18 samples each), chicken luncheon (18), chicken burger (12) and chicken kofta (12) and Group (B) includes 60 non-packaged low brand samples of beef luncheon, burger, kofta, minced meat and sausage(6 samples each) and chicken luncheon, burger, kofta, minced meat and sausage (6 samples each) from meat shops. All samples were analyzed for detection of adulteration with equine and/or pork meat by Polymerase Chain Reaction (PCR) technique using specific primers for equine and pork species. The obtained result revealed that adulteration rate of processed meat products with equine meat species was found to be 3.2 % (5 positive samples out of 156 examined samples) so it was recommended that rapid movement of responsible authorities with cooperation with scientific academies to protect health of consumers and prevent illegal substitution of meat. [ABSTRACT FROM AUTHOR]

Deleterious effects of climate change and human activities, as well as diverse environmental stresses, present critical challenges to food production and the maintenance of natural diversity. These challenges may be met by the development of novel crop varieties with increased biotic or abiotic resistance that enables them to thrive in marginal lands. However, considering the diverse interactions between crops and environmental factors, it is surprising that evolutionary principles have been underexploited in addressing these food and environmental challenges. Compared with domesticated cultivars, crop wild relatives ( CWRs) have been challenged in natural environments for thousands of years and maintain a much higher level of genetic diversity. In this review, we highlight the significance of CWRs for crop improvement by providing examples of CWRs that have been used to increase biotic and abiotic stress resistance/tolerance and overall yield in various crop species. We also discuss the surge of advanced biotechnologies, such as next-generation sequencing technologies and omics, with particular emphasis on how they have facilitated gene discovery in CWRs. We end the review by discussing the available resources and conservation of CWRs, including the urgent need for CWR prioritization and collection to ensure continuous crop improvement for food sustainability. [ABSTRACT FROM AUTHOR]

Deleterious effects of climate change and human activities, as well as diverse environmental stresses, present critical challenges to food production and the maintenance of natural diversity. These challenges may be met by the development of novel crop varieties with increased biotic or abiotic resistance that enables them to thrive in marginal lands. However, considering the diverse interactions between crops and environmental factors, it is surprising that evolutionary principles have been underexploited in addressing these food and environmental challenges. Compared with domesticated cultivars, crop wild relatives (CWRs) have been challenged in natural environments for thousands of years and maintain a much higher level of genetic diversity. In this review, we highlight the significance of CWRs for crop improvement by providing examples of CWRs that have been used to increase biotic and abiotic stress resistance/tolerance and overall yield in various crop species. We also discuss the surge of advanced biotechnologies, such as next-generation sequencing technologies and omics, with particular emphasis on how they have facilitated gene discovery in CWRs. We end the review by discussing the available resources and conservation of CWRs, including the urgent need for CWR prioritization and collection to ensure continuous crop improvement for food sustainability.