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Background: Cadence-controlled walking may be a desirable approach for older adults to self-monitor exercise intensity and achieve physical activity guidelines. We examined the acute effects of cadence-controlled walking on cognition and vascular function in physically inactive older adults. Methods: In a randomized crossover design, 26 participants (65% females, 67.8 ± 11.3 years) underwent 30-min acute exercise (walking at 100 steps/min) and control (sitting) conditions. We measured cognition, central blood pressure (BP), and arterial stiffness before, and immediately, after each condition. Results: We observed significant Time × Condition interactions in the Flanker Inhibitory Control and Attention (Flanker) test and Dimensional Change Card Sort (DCCS) test scores, and in central systolic BP, central pulse pressure, and carotid to femoral pulse wave velocity (p <.05). The Flanker and DCCS scores significantly increased after walking (d = 0.4 and 0.5, respectively), but not after sitting. Central systolic BP, central pulse pressure, and carotid to femoral pulse wave velocity significantly increased after sitting but remained unchanged after acute walking (d = 0.4–0.2), with p-values <.05. After walking, significant correlations were observed between DCCS and diastolic BP and central pulse pressure change scores and change scores in central pulse wave velocity, Flanker, and DCCS (rs = −0.45 to −0.52). Conclusion: These findings suggest that a single bout of cadence-controlled walking elicited an immediate improvement in cognition and might have mitigated increases in arterial stiffness and central BP observed in the seated control condition. Further research is needed to examine the association between cognition and vascular function following acute exercise compared to control conditions. Significance: Our findings may have practical implications for developing daily physical activity recommendations for improving the cognitive health for successful aging. [ABSTRACT FROM AUTHOR]

Context Ghrelin circulates in acylated (AG) and deacylated (DAG) forms, which are known to affect appetite. Although acute exercise has been shown to modulate ghrelin levels, data on the impact of exercise intensity on AG and DAG levels and their effects on appetite are sparse and primarily limited to males. Objective To investigate the effect of exercise intensity and sex on ghrelin levels and appetite in untrained humans. Methods Eight males (age: 43.1 ± 10.9 years; body mass index [BMI]: 22.2 ± 1.7 kg/m2; peak oxygen consumption [VO2peak]: 36.3 ± 6.4 mL/kg/min) and 6 females (age: 32.2 ± 11.1 years; BMI: 22.7 ± 1.0 kg/m2; VO2peak: 29.2 ± 4.0 mL/kg/min) completed a maximal graded cycle ergometer lactate threshold (LT)/VO2peak test. These data were used to determine the exercise intensity on 3 subsequent randomized control or calorically matched cycle exercise bouts: (1) CON, no exercise; (2) MOD, the power output at LT; (3) HIGH, the power output associated with 75% of the difference between LT and VO2peak. Perception of appetite was analyzed using visual analog scales. Results Females had higher levels of total ghrelin (TG) (P =.03) and DAG (P =.01) at baseline than males. Both groups exhibited reduced DAG levels in HIGH compared with MOD and CON (P <.0001-.004); however, only females had significantly reduced AG in HIGH (P <.0001). Hunger scores were higher in MOD than in CON (P <.01). Conclusion High-intensity may be superior to moderate-intensity exercise for reducing ghrelin levels and modifying hunger, and sex may impact this response. [ABSTRACT FROM AUTHOR]

This study was to differentiate the acute effects of random motor skill practice and acute cardiovascular exercise on the task performance in visuospatial working memory (VSWM). 24 healthy adults with no golf experience were randomized into random motor skill practice (i.e., golf putting task) and acute cardiovascular exercise (i.e., 64% and 76 % of predicted maxi-mum heart rate) groups. Pre-test and post-test were administered for two VSWM tasks (i.e., memory matrix and rotation matrix). The performance of VSWM was improved immediately after the acute intervention. However, the improvement in retention effect was not maintained. In addition, no group differences were noted between random motor skill practice and acute cardiovascular exercise during post-test. The findings suggested the temporal effects of acute intervention. There is need to add a true control group for further research with larger sample size to examine the role of exercise modalities between acute intervention and executive function. [ABSTRACT FROM AUTHOR]

• Acute exercise has a positive effect on enhancing cognitive function in elderly individuals with AD and MCI. • The effectiveness of acute exercise in preventing various types of dementia and AD shows a dose-response trend. • Acute exercise (aerobic or resistance) can temporarily increase the levels of some neuroprotective growth factors and enhance the neurocognitive abilities of elderly MCI patients. This narrative review follows the JBI approach and comprehensively explores the effects and mechanisms of acute exercise on cognitive function in Alzheimer's disease (AD) and Mild cognitive impairment (MCI) patients. The results showed that the combination of acute exercise and cognitive training improved the cognitive function of AD patients better than aerobic exercise or resistance training alone. For patients with MCI, moderate intensity acute aerobic exercise and resistance exercise were beneficial to enhance Inhibitory control (IC), but high-intensity acute exercise was adverse to improve IC; Brain-derived neurotrophic factor (BDNF) and Insulin-like growth factor 1 (IGF-1) may assume the potential mediating mechanism of acute exercise on cognitive function in AD and MCI patients, but more research is needed to further confirm this mechanism. [ABSTRACT FROM AUTHOR]

Abstract Studies have shown that acute exercise alters the expression of circulating neutrophil and peripheral blood mononuclear cell (PBMC) genes, affecting a wide range of processes from cellular growth to the promotion of inflammatory and anti-inflammatory responses. In this study, we identified differential gene expression associated with acute exercise and PBMC in puberty children through the GEO database. We utilized bioinformatics technology to analyze the impact of acute exercise on PBMC and identified key genes involving the puberty children. Combining two datasets of gene expression, we identified 197 shared differentially expressed genes (DEGs) in PBMC before and after exercise. We conducted pathway analysis of these DEGs and built a gene co-expression network. The identification of hub genes was achieved through the utilization of protein-protein interaction (PPI) networks. 268 shared DEGs were identified in the GSE11761 dataset in pre- and post-exercise groups, while 352 differential genes were identified between the pre- and post-exercise groups of females in the GSE14642 dataset. A total of 197 shared genes were identified between the two datasets. Seven core genes were identified by MCODE and CytoHubba, namely IL2RB, KLRD1, GZMB, TBX21, PRF1, HAVCR2, and GZMA. Bioinformatics techniques are effective in screening and analyzing PBMC-associated DEGs in children undergoing acute pre- and post-exercise puberty. Microarray analysis of PBMCs in children undergoing puberty can identify molecules that may predict acute exercise responses. This study provides insights for further exploration of the mechanisms and targets of acute exercise on the organism.

While under physiological conditions angiotensin‐converting enzyme 2 (ACE2) is an antagonist of vasoconstrictive agents in the renin–angiotensin–aldosterone system (RAAS), in the context of SARS coronavirus 2 (SARS‐CoV‐2) ACE2 serves as the gateway into cells. Furthermore, RAAS has previously been shown to be influenced by exercise training and is suggested to be involved in skeletal muscle mass maintenance. Given this connection, the investigation of circulating ACE2 plasma protein concentration before and following acute and chronic endurance and resistance exercise could increase the understanding of the implications of the exposure of athletes to SARS‐CoV‐2. Therefore, this study investigated levels of circulating ACE2 in lifelong high‐level trained endurance and resistance athletes and control subjects in response to either acute endurance or resistance exercise. Results show no baseline differences in absolute ACE2 concentration between groups, but a strong negative correlation with levels of fitness and positive correlation with BMI in control subjects. Furthermore, acute endurance exercise significantly increased ACE2 levels across all groups, but only in the strength group in response to resistance exercise. This indicates that circulating ACE2 plasma levels are influenced by levels of fitness and health, and that acute endurance exercise has a stronger effect on plasma ACE2 levels than resistance exercise. [ABSTRACT FROM AUTHOR]

Background: Mobilization of certain immune cells may improve the ability of the immune system to combat tumor cells, but the effect of acute exercise on mobilizing immune cells has been sparsely investigated in cancer patients. Therefore, we examined how acute exercise influences circulating immune cells in breast cancer patients. Methods: Nineteen newly diagnosed breast cancer patients aged 36–68 performed 30 minutes of moderate-intensity exercise with a cycle ergometer. Blood samples were collected at various time points: at rest, at 15 (E15) and 30 minutes (E30) after onset of the exercise, and at 30 and 60 minutes postexercise. We analyzed several immune cell subsets using flow cytometry. Results: Acute exercise increased the number of total leukocytes, neutrophils, lymphocytes, monocytes, basophils, total T-cells, CD4+ T-cells, T helper (Th) 2- cells, Th 17-cells, CD8+ T-cells, CD4- CD8- T-cells, CD56+ natural killer (NK) cells, and CD14- CD16+ monocytes. Many of the changes were transient. Proportions of NK-cells and CD8+ T-cells increased, while the proportion of myeloid derived suppressor cells (MDSCs) reduced, and proportion of regulatory T-cells remained unchanged by exercise. Several associations were detected between cell mobilizations and disease state. For instance, tumor size correlated negatively with NK cell mobilization at E15, and progesterone receptor positivity correlated negatively with CD8+ T-cell mobilization. Conclusion: The findings show that the proportions of CD8+ T-cells and NK cells increased and the proportion of MDSCs proportion decreased in breast cancer patients after 30-minute exercise, suggesting a change in the profile of circulating immune cells towards more cytotoxic/anti-tumorigenic. The mobilization of some immune cells also appears to be related to the disease state. [ABSTRACT FROM AUTHOR]

Regular exercise benefits learning and memory in older adults, but the neural mechanisms mediating these effects remain unclear. Evidence in young adults indicates that acute exercise creates a favourable environment for synaptic plasticity by enhancing cortical disinhibition. As such, we investigated whether plasticity‐related disinhibition mediated the relationship between cardiorespiratory fitness and memory function in healthy older adults (n = 16, mean age = 66.06). Participants completed a graded maximal exercise test and assessments of visual and verbal memory, followed by two counterbalanced sessions involving 20 min of either high‐intensity interval training exercise or rest. Disinhibition was measured following intermittent theta burst stimulation via paired‐pulse transcranial magnetic stimulation. In line with our hypotheses, we observed a positive correlation between cardiorespiratory fitness and verbal memory, which was mediated by plasticity‐related cortical disinhibition. Our novel finding implicates cortical disinhibition as a mechanism through which the effects of acute bouts of exercise may translate to improved memory in older adults. This finding extends current understanding of the physiological mechanisms underlying the positive influence of cardiorespiratory fitness for memory function in older adults, and further highlights the importance of promoting exercise engagement to maintain cognitive health in later life. Key points: There are well established benefits of regular exercise for memory function in older adults, but the mechanisms are unclear. Cortical disinhibition is important for laying down new memories, and is enhanced following acute exercise in young adults, suggesting it is a potential mechanism underlying these benefits in ageing.Older adults completed a fitness test and assessments of memory, followed by two sessions involving either 20 min of exercise or rest. Disinhibition was measured following intermittent theta burst stimulation via paired‐pulse transcranial magnetic stimulation.Cardiorespiratory fitness was positively associated with memory performance. Higher fitness was associated with enhanced cortical disinhibition following acute exercise.Cortical disinhibition completely mediated the relationship between fitness and memory.This novel finding provides a mechanistic account for the positive influence of cardiorespiratory fitness on memory in later life, and emphasises the importance of regular exercise for cognitive health in older populations. [ABSTRACT FROM AUTHOR]

One exercise session can increase subsequent insulin-stimulated glucose uptake (ISGU) by skeletal muscle from rodents and humans of both sexes. We recently found that concurrent mutation of three key sites to prevent their phosphorylation (Ser588, Thr642, and Ser704) on Akt substrate of 160 kDa (AS160; also known as TBC1D4) reduced the magnitude of the enhancement of postexercise ISGU (PEX-ISGU) by muscle from male, but not female rats. However, we did not test the role of individual phosphorylation sites on PEX-ISGU. Accordingly, our current aim was to test whether AS160 Ser704 phosphorylation (pSer704) is required for elevated PEX-ISGU by muscle. AS160-knockout (AS160-KO) rats (female and male) were studied when either in sedentary or 3 h after acute exercise. Adeno-associated virus (AAV) vectors were used to enable muscle expression of wild-type AS160 (AAV-WT-AS160) or AS160 mutated Ser704 to alanine to prevent phosphorylation (AAV-1P-AS160). Paired epitrochlearis muscles from each rat were injected with AAV-WT-AS160 or AAV-1P-AS160. We discovered that regardless of sex 1) AS160 abundance in AS160-KO rats was similar in paired muscles expressing WT-AS160 versus 1P-AS160; 2) muscles from exercised versus sedentary rats had greater ISGU, and PEX-ISGU was slightly greater for muscles expressing 1P-AS160 versus contralateral muscles expressing WT-AS160; and 3) pAS160Thr642 was lower in muscles expressing 1P-AS160 versus paired muscles expressing WT-AS160. These results indicate that pAS160Ser704 was not essential for elevated PEX-ISGU by skeletal muscle from rats of either sex. Furthermore, elimination of the postexercise increase in pAS160Thr642 did not lessen the postexercise effect on ISGU. NEW & NOTEWORTHY: The current study evaluated the role of Akt substrate of 160 kDa (AS160) phosphorylation on Ser704 in increased insulin-stimulated glucose uptake by skeletal muscle after exercise. Adeno-associated virus vectors were engineered to express either wild-type-AS160 or AS160 mutated so that it could not be phosphorylated on Ser704 in paired muscles from AS160-knockout rats. The results demonstrated that AS160 phosphorylation on Ser704 was not essential for exercise-induced elevation in insulin-stimulated glucose uptake by rats of either sex. [ABSTRACT FROM AUTHOR]

Protein acetylation, which is dynamically maintained by histone acetyltransferases (HATs) and deacetylases (HDACs), might play essential roles in hippocampal exercise physiology. However, whether HATs/HDACs are imbalanced during the recovery phase following acute exercise has not been determined. Groups of exercised mice with different recovery periods after acute exercise (0 h, 0.5 h, 1 h, 4 h, 7 h, and 24 h) were constructed, and a group of sham-exercised mice was used as the control. The mRNA levels of HATs and HDACs were detected via real-time quantitative polymerase chain reaction. Lysine acetylation on the total proteins and some specific locations on histones were detected via western blotting, as were various acylation modifications on the total proteins. Except for four unaffected genes (Hdac4, Ncoa1, Ncoa2, and Sirt1), the mRNA expression trajectories of 21 other HATs or HDACs affected by exercise could be categorized into three clusters. The genes in Cluster 1 increased quickly following exercise, with a peak at 0.5 h and/or 1 h, and remained at high levels until 24 h. Cluster 2 genes presented a gradual increase with a delayed peak at 4 h or 7 h postexercise before returning to baseline. The expression of Cluster 3 genes decreased at 0.5 h and/or 1 h, with some returning to overexpression (Hdac1 and Sirt3). Although most HATs were upregulated and half of the affected HDACs were downregulated at 0.5 h postexercise, the global or residue-specific histone acetylation levels were unchanged. In contrast, the levels of several metabolism-related acylation products of total proteins, including acetylation, succinylation, 2-hydroxyisobutyryllysine, β-hydroxybutyryllysine, and lactylation, decreased and mainly occurred on nonhistones immediately after exercise. During the 24-h recovery phase after acute exercise, the transcriptional trajectory of HATs or the same class of HDACs in the hippocampus exhibited heterogeneity. Although acute exercise did not affect the selected sites on histone lysine residues, it possibly incurred changes in acetylation and other acylation on nonhistone proteins. [ABSTRACT FROM AUTHOR]

The article "Cycling away from cancer: can aerobic training enhance interleukin-15 response to acute exercise?" published in the Journal of Physiology discusses the impact of physical activity on cancer development and recurrence, focusing on interleukin-15 (IL-15) as a potential anti-oncogenic agent. The study found that acute exercise increased circulating IL-15 concentrations, regardless of persistent exercise training. The research involved cancer survivors undergoing high-intensity interval training and highlighted the importance of exercise in modulating IL-15 and other inflammatory markers. The study suggests that aerobic exercise at high intensity can lead to significant IL-15 release in cancer survivors, but further research is needed to determine the optimal exercise modality. [Extracted from the article]

Poor cardiorespiratory fitness may mediate vascular impairments at rest and following an acute bout of exercise in young healthy individuals. This study aimed to compare flow mediated dilation (FMD) and vascular augmentation index (AIx75) between young adults with low, moderate, and high levels of cardiorespiratory fitness before and after an acute bout of aerobic exercise. Forty-three participants (22 men; 21 women) between 18 and 29 years of age completed the study. Participants were classified into low, moderate, and high health-related cardiorespiratory fitness groups according to age- and sex-based relative maximal oxygen consumption (V˙O2 max) percentile rankings. FMD was performed using Doppler ultrasound and AIx75 was performed using pulse wave analysis at baseline and 60-min after a 30-min bout of treadmill running at 70% V˙O2 max. A significant interaction (p ​= ​0.047; ηp2 ​= ​0.142) was observed, with the moderate fitness group exhibiting a higher FMD post-exercise compared with baseline ([6.7% ​± ​3.1%] vs. [8.5% ​± ​2.8%], p ​= ​0.028; d ​= ​0.598). We found a significant main effect of group for AIx75 (p ​= ​0.023; ηp2 ​= ​0.168), with the high fitness group exhibiting lower AIx75 compared to low fitness group ([−10% ​± ​10%] vs. [2% ​± ​10%], respectively, p ​= ​0.019; g ​= ​1.07). This was eliminated after covarying for body fat percentage (p ​= ​0.489). Our findings suggest that resting FMD and AIx75 responses are not significantly influenced by cardiorespiratory fitness, but FMD recovery responses to exercise may be enhanced in individuals with moderate cardiorespiratory fitness levels.

Background: The extracellular matrix (ECM) of skeletal muscle plays a pivotal role in tissue repair and growth, and its remodeling tightly regulated by matrix metalloproteinases (MMPs), tissue inhibitors of metalloproteinases (TIMPs), and inflammatory cytokines. This study aimed to investigate changes in the mRNA expression of MMPs (Mmp-2 and Mmp-14), TIMPs (Timp-1 and Timp-2), and inflammatory cytokines (Il-1β, Tnf-α, and Tgfβ1) in the soleus (SOL) and extensor digitorum longus (EDL) muscles of rats following acute treadmill exercise. Additionally, muscle morphology was examined using hematoxylin and eosin (H&E) staining. Methods and results: Male rats were subjected to acute treadmill exercise at 25 m/min for 60 min with a %0 slope. The mRNA expression of ECM components and muscle morphology in the SOL and EDL were assessed in both sedentary and exercise groups at various time points (immediately (0) and 1, 3, 6, 12, and 24 h post-exercise). Our results revealed a muscle-specific response, with early upregulation of the mRNA expression of Mmp-2, Mmp-14, Timp-1, Timp-2, Il-1β, and Tnf-α observed in the SOL compared to the EDL. A decrease in Tgfβ1 mRNA expression was evident in the SOL at all post-exercise time points. Conversely, Tgfβ1 mRNA expression increased at 0 and 3 h post-exercise in the EDL. Histological analysis also revealed earlier cell infiltration in the SOL than in the EDL following acute exercise. Conclusions: Our results highlight how acute exercise modulates ECM components and muscle structure differently in the SOL and EDL muscles, leading to distinct muscle-specific responses. Exercise-induced skeletal muscle ECM remodeling via matrix metalloproteinases and inflammatory cytokines [ABSTRACT FROM AUTHOR]

Objective: The aim of this study was to investigate nailfold capillary parameters in community-dwelling individuals aged over 60 years who have hypertension and do not exercise regularly. Furthermore, the study examined the correlations between capillary function and other health-related indicators. Design: This study was a single- center pilot trial. Setting: The study took place in the Faculty of Health, Tsukuba University of Technology, Japan. Participants: Hypertensive community-dwelling elderly people took part in the study. Intervention: Microcirculation was observed before and 1 min after an arm-curl exercise by means of capillary microscopy of the non-exercised limb. Additionally, we examined other health-related indicators. Methods: We measured the acute effects of reperfusion on nailfold density, flow, and diameters. Secondary outcomes included the correlations between microvascular parameters and other health-related indicators. We hypothesized that brief exercise could enhance microcirculation reperfusion and correlate with other health-related parameters. Results: There were 20 participants with a mean (SD) age of 67.1 (5.8) years. The capillary flow rate changed from 2.3 ± 6.7 to 2.7 ± 0.2 log µm/s (p < 0.01), and the capillary density changed from 0.8 ± 0.2 to 0.9 ± 0.1 log/mm (p < 0.01), which included a significant increase in the non-exercising limb. Significant correlations were observed between the nailfold capillary diameter and body fat mass, the capillary diameter and physical activity, and the capillary density and bone mineral density. Conclusions: The acute effects of exercise on high-risk elderly individuals can be safe, and even 1 of min exercise can potentially improve their nailfold capillary function, despite the brief time, compared to no exercise. The results indicate that capillaries have an impact on the function of the whole body. Thus, they may be a useful diagnostic tool for assessing nailfold capillaries. [ABSTRACT FROM AUTHOR]

Purpose: We examined heart rate variability (HRV) and baroreflex sensitivity (BRS) disease- and age-related response at 10-and 60-min after an acute high-intensity interval (HIIE) and moderate continuous exercise (MICE) in older adults with and without type 2 diabetes mellitus (T2DM) and healthy young adults. Methods: Twelve older male adults with (57–84 years) and without T2DM (57–76 years) and 12 healthy young male adults (20–40 years) completed an isocaloric acute bout of HIIE, MICE, and a non-exercise condition in a randomized order. Time and Wavelets-derived frequency domain indices of HRV and BRS were obtained in a supine position and offline over 2-min time-bins using Matlab. Results: HIIE but not MICE reduced natural logarithm root mean square of successive differences (Ln-RMSSD) (d = − 0.85; 95% CI − 1.15 to − 0.55 ms, p < 0.001), Ln-high-frequency power (d = − 1.60; 95% CI − 2.24 to − 0.97 ms2; p < 0.001), and BRS (d = − 6.32; 95% CI − 9.35 to − 3.29 ms/mmHg, p < 0.001) in adults without T2DM (averaged over young and older adults without T2DM), returning to baseline 60 min into recovery. These indices remained unchanged in older adults with T2DM after HIIE and MICE. Older adults with T2DM had lower resting Ln-RMSSD and BRS than aged-matched controls (Ln-RMSSD, d = − 0.71, 95% CI − 1.16 to − 0.262 ms, p = 0.001; BRS d = − 3.83 ms/mmHg), 95% CI − 6.90 to − 0.76, p = 0.01). Conclusions: Cardiovagal modulation following acute aerobic exercise is intensity-dependent only in adults without T2DM, and appears age-independent. These findings provide evidence of cardiac autonomic impairments in older adults with T2DM at rest and following aerobic exercise. [ABSTRACT FROM AUTHOR]

Research findings reveal a relationship between acute bouts of exercise and procedural/declarative memory. Prior systematic reviews report small/moderate effects of acute exercise on episodic long-term declarative memory. A somewhat overlooked issue is the influence of exercise on specific types of episodic memory processing. The primary focus of this systematic review and meta-analysis was to evaluate the effects of acute bouts of exercise prior to, during, and following encoding on free-, cued-recall, and recognition episodic memory. PubMed, Scopus, and EBSCO databases were entered, and 42 experiments were subject tometa-analysis. Exercise prior to encoding improved memory (d = 0.23) and affected free-recall (d = 0.40) tests of memory more than cued-recall (d = 0.08) or recognition (d = -0.06) memory. Exercise following encoding improved memory (d = 0.33) and affected recognition (d = 0.62) memory more than free- (d = 0.19) or cued-recall (d = 0.14) memory. Exercise during encoding did not influence memory (d = -0.04). Moderator analyses revealed that exercise before encoding impacted memory differentially on the basis of age, exercise type, and test-timing. When exercise occurred after encoding, age and exercise type, but not timing of the test influenced memory performance. Exercise before and after encoding has selective effects on episodicmemory. Additional experiments that evaluate how bouts of exercise influence memory encoding are warranted. [ABSTRACT FROM AUTHOR]

Introduction: Physical activity influences psychological well-being. This study aimed to determine the impact of exercise intensity on psychological well-being and alterations in emotion-related brain functional connectivity (FC). Methods: Twenty young, healthy, trained athletes performed a low- and highintensity interval exercise (LIIE and HIIE) as well as a control condition in a within-subject crossover design. Before and after each condition, Positive And Negative Affect Scale (PANAS) was assessed as well as resting-state functional MRI (rs-fMRI). Voxel-wise FC was examined for bilateral amygdala seed region to whole-brain and emotion-related anatomical regions (e.g., insula, temporal pole, precuneus). Data analyses were performed using linear mixed-effect models with fixed factors condition and time. Results: The PANAS Positive Affect scale showed a significant increase after LIIE and HIIE and a significant reduction in Negative Affect after the control condition. In rs-fMRI, no significant condition-by-time interactions were observed between the amygdala and whole brain. Amygdala-precuneus FC analysis showed an interaction effect, suggesting reduced post-exercise anticorrelation after the control condition, but stable, or even slightly enhanced anticorrelation for the exercise conditions, especially HIIE. Discussion: In conclusion, both LIIE and HIIE had positive effects on mood and concomitant effects on amygdala-precuneus FC, particularly after HIIE. Although no significant correlations were found between amygdala-precuneus FC and PANAS, results should be discussed in the context of affective disorders in whom abnormal amygdala-precuneus FC has been observed. [ABSTRACT FROM AUTHOR]

Purpose: Efficacy of exercise to improve renal health and filtration remains understudied in adults with moderate-stages (stages G3a-b) of chronic kidney disease (CKD). Acute exercise may contribute clinically relevant information for exercise-related augmentation of renal health and filtration in CKD. Urine epidermal growth factor (uEGF) and cystatin C (CyC) are proposed to be more direct biomarkers of renal health and filtration. This study aimed to determine the influence of continuous moderate-intensity exercise (CMIE) and high-intensity interval exercise (HIIE) on traditional and novel biomarkers of renal health and filtration in moderate-stages of CKD. Methods: Twenty CKD participants completed 30 minutes of both CMIE and HIIE. Blood and urine samples were obtained pre, 1-hour, and 24-hours post-exercise. Traditional—serum creatinine (sCr) urine creatinine, novel—uEGF, uEGF ratio (uEGFr), and CyC. Estimates of glomerular filtration rate (eGFR)—modification of diet in renal disease (MDRD) and the CKD-Epidemiology (CKD-EPI)—responses were compared pre, 1 hr, and 24 hr post-exercise. Results: Relative to pre-exercise measures, uEGF remained unchanged in both exercise conditions. However, uEGFr was 5.4% greater 24-hours after HIIE (P =.05), while uEGFr remained unchanged with CMIE. sCr decreased 6 to 19% 1-hour post-exercise in both conditions (P =.009). On average renal filtration increased in eGFR-MDRD (7.2 ± 2.0 ml/min/1.73 m2) (P =.007) and eGFR-CKD-EPI (8.6 ± 2.3 ml/min/1.73 m2) 1-hour post-exercise (P =.009). Conclusion: By clinical estimates, renal filtration in CKD was not normalized but transiently improved regardless of exercise condition, with HIIE eliciting transient improvements in renal health. [ABSTRACT FROM AUTHOR]

Simple Summary: Cancer-related fatigue is a prevalent symptom, with a significant impact on the daily lives of those affected. While physical exercise has demonstrated effectiveness in reducing the intensity and duration of fatigue, the literature still lacks sufficient evidence on the physiological mechanisms explaining this impact. This conceptual review aimed to provide an overview of the evidence regarding the effect of acute exercise on peripheral and neuronal inflammation, immune function, and the neuroendocrine system in the context of cancer. We aim to integrate these pathways into a conceptual model that can serve as a starting point for further research into the physiological mechanisms linking exercise and cancer-related fatigue. Cancer-related fatigue (CRF) is a prevalent and persistent issue affecting cancer patients, with a broad impact on their quality of life even years after treatment completion. The precise mechanisms underlying CRF remain elusive, yet its multifaceted nature involves emotional, physical, and cognitive dimensions. The absence of effective medical treatments has prompted researchers to explore integrative models for potential insights. Notably, physical exercise emerges as a promising strategy for managing CRF and related symptoms, as studies showed a reduction in CRF ranging from 19% to 40%. Current recommendations highlight aerobic training at moderate intensity as beneficial, although questions about a dose–response relationship and the importance of exercise intensity persist. Despite the positive impact of exercise on CRF, the underlying mechanisms remain elusive. This review aims to provide a theoretical model explaining how aerobic exercise may alleviate CRF. Focusing on acute exercise effects, this review delves into the potential influence on peripheral and neural inflammation, immune function dysregulation, and neuroendocrine system disruptions. The objective is to enhance our understanding of the intricate relationship between exercise and CRF, ultimately paving the way for tailored interventions and potential pharmacological treatments for individuals unable to engage in physical exercise. [ABSTRACT FROM AUTHOR]

A better understanding of the cellular and molecular mechanisms that are involved in skeletal muscle adaptation to exercise is fundamentally important to take full advantage of the enormous benefits that exercise training offers in disease prevention and therapy. The aim of this study was to elucidate the transcriptional signatures that distinguish the endurance-trained and untrained muscles in young adult males (24 ± 3.5 years). We characterized baseline differences as well as acute exercise-induced transcriptome responses in vastus lateralis biopsy specimens of endurance-trained athletes (ET; n = 8; VO2max, 67.2 ± 8.9 mL/min/kg) and sedentary healthy volunteers (SED; n = 8; VO2max, 40.3 ± 7.6 mL/min/kg) using microarray technology. A second cohort of SED volunteers (SED-T; n = 10) followed an 8-week endurance training program to assess expression changes of selected marker genes in the course of skeletal muscle adaptation. We deciphered differential baseline signatures that reflected major differences in the oxidative and metabolic capacity of the endurance-trained and untrained muscles. SED-T individuals in the training group displayed an up-regulation of nodal regulators of oxidative adaptation after 3 weeks of training and a significant shift toward the ET signature after 8 weeks. Transcriptome changes provoked by 1 h of intense cycling exercise only poorly overlapped with the genes that constituted the differential baseline signature of ETs and SEDs. Overall, acute exercise-induced transcriptional responses were connected to pathways of contractile, oxidative, and inflammatory stress and revealed a complex and highly regulated framework of interwoven signaling cascades to cope with exercise-provoked homeostatic challenges. While temporal transcriptional programs that were activated in SEDs and ETs were quite similar, the quantitative divergence in the acute response transcriptomes implicated divergent kinetics of gene induction and repression following an acute bout of exercise. Together, our results provide an extensive examination of the transcriptional framework that underlies skeletal muscle plasticity. [ABSTRACT FROM AUTHOR]

Acute exercise induces changes within the T-cell compartment, especially in cytotoxic CD8+ memory subsets, depending on exercise intensity and duration. It is unclear whether exercise-induced changes in major T-cell subsets differ in response to acute high-intensity interval training (HIIT) or moderate-intensity continuous training (MICT) and whether sex-specific effects exist. Twenty-four recreationally active runners (females: n=12, 27.8±4.1years, 54.4±4.6 ml*kg-1 *min-1 ; males: n=12, 31.6±3.8years, 58.9±7.7 ml*kg-1 *min-1) participated in this randomized controlled crossover study, and conducted an energy- and duration-matched HIIT and MICT session. Blood was sampled before (T1), immediately (T2) and 1 h after exercise (T3). Flow cytometry was used to identify T-cell populations. HIIT decreased the proportion of CD8+ T-cells more pronounced at T3 compared to MICT (p=0.007), induced a significantly stronger increase in the CD8+ effector memory (TEM) cell proportion at T2 (p=0.032), and decreased CD4+ central memory proportion more pronounced at T2 (p=0.029). A decrease below baseline CD8+ TEM proportion at T3 was observed only after HIIT (p<0.001). No interaction effects between sexes were revealed. Taken together, HIIT represents a more potent stimulus to induce shifts mainly within the cytotoxic CD8+ T-cell compartment, thereby giving implications to investigate the role of HIIT on the cell´s effector phenotype and function in more detail. [ABSTRACT FROM AUTHOR]

Poor cardiorespiratory fitness may mediate vascular impairments at rest and following an acute bout of exercise in young healthy individuals. This study aimed to compare flow mediated dilation (FMD) and vascular augmentation index (AIx75) between young adults with low, moderate, and high levels of cardiorespiratory fitness before and after an acute bout of aerobic exercise. Forty-three participants (22 men; 21 women) between 18 and 29 years of age completed the study. Participants were classified into low, moderate, and high health-related cardiorespiratory fitness groups according to age- and sex-based relative maximal oxygen consumption (V̇O2 max) percentile rankings. FMD was performed using Doppler ultrasound and AIx75 was performed using pulse wave analysis at baseline and 60-min after a 30-min bout of treadmill running at 70% V̇O2 max. A significant interaction (p = 0.047; ηp ² = 0.142) was observed, with the moderate fitness group exhibiting a higher FMD post-exercise compared with baseline ([6.7% ± 3.1%] vs. [8.5% ± 2.8%], p = 0.028; d = 0.598). We found a significant main effect of group for AIx75 (p = 0.023; ηp ² = 0.168), with the high fitness group exhibiting lower AIx75 compared to low fitness group ([10% ± 10%] vs. [2% ± 10%], respectively, p = 0.019; g = 1.07). This was eliminated after covarying for body fat percentage (p = 0.489). Our findings suggest that resting FMD and AIx75 responses are not significantly influenced by cardiorespiratory fitness, but FMD recovery responses to exercise may be enhanced in individuals with moderate cardiorespiratory fitness levels. [ABSTRACT FROM AUTHOR]

Abstract While under physiological conditions angiotensin‐converting enzyme 2 (ACE2) is an antagonist of vasoconstrictive agents in the renin–angiotensin–aldosterone system (RAAS), in the context of SARS coronavirus 2 (SARS‐CoV‐2) ACE2 serves as the gateway into cells. Furthermore, RAAS has previously been shown to be influenced by exercise training and is suggested to be involved in skeletal muscle mass maintenance. Given this connection, the investigation of circulating ACE2 plasma protein concentration before and following acute and chronic endurance and resistance exercise could increase the understanding of the implications of the exposure of athletes to SARS‐CoV‐2. Therefore, this study investigated levels of circulating ACE2 in lifelong high‐level trained endurance and resistance athletes and control subjects in response to either acute endurance or resistance exercise. Results show no baseline differences in absolute ACE2 concentration between groups, but a strong negative correlation with levels of fitness and positive correlation with BMI in control subjects. Furthermore, acute endurance exercise significantly increased ACE2 levels across all groups, but only in the strength group in response to resistance exercise. This indicates that circulating ACE2 plasma levels are influenced by levels of fitness and health, and that acute endurance exercise has a stronger effect on plasma ACE2 levels than resistance exercise.

Limited research exists regarding the effects of resistance exercise (RE) combined with whole body vibration (WBV), blood flow restriction (BFR), or both on the neuropsychological performance of working memory (WM) in late-middle-aged and older adults and regarding the physiological mechanisms underlying this effect. This study thus explored the acute molecular and neurophysiological mechanisms underlying WM performance following RE combined with WBV, BFR, or both. Sixty-six participants were randomly assigned into a WBV, BFR, or WBV + BFR group. Before and after the participants engaged in a single bout of isometric RE combined with WBV, BFR, or both, this study gathered data on several neurocognitive measures of WM performance, namely, accuracy rate (AR), reaction time (RT), and brain event-related potential (specifically P3 latency and amplitude), and data on biochemical indices, such as the levels of insulin-like growth factor-1 (IGF-1), norepinephrine (NE), and brain-derived neurotrophic factor (BDNF). Although none of the RE modalities significantly affected RTs and P3 latencies, ARs and P3 amplitudes significantly improved in the WBV and WBV + BFR groups. The WBV + BFR group exhibited greater improvements than the WBV group did. Following acute RE combined with WBV, BFR, or both, IGF-1 and NE levels significantly increased in all groups, whereas BDNF levels did not change. Crucially, only the changes in NE levels were significantly correlated with improvements in ARs in the WBV + BFR and WBV groups. The findings suggest that combining acute RE with WBV, BFR, or both could distinctively mitigate neurocognitive decline in late-middle-aged and older adults.

BackgroundMobilization of certain immune cells may improve the ability of the immune system to combat tumor cells, but the effect of acute exercise on mobilizing immune cells has been sparsely investigated in cancer patients. Therefore, we examined how acute exercise influences circulating immune cells in breast cancer patients.MethodsNineteen newly diagnosed breast cancer patients aged 36–68 performed 30 minutes of moderate-intensity exercise with a cycle ergometer. Blood samples were collected at various time points: at rest, at 15 (E15) and 30 minutes (E30) after onset of the exercise, and at 30 and 60 minutes post-exercise. We analyzed several immune cell subsets using flow cytometry.ResultsAcute exercise increased the number of total leukocytes, neutrophils, lymphocytes, monocytes, basophils, total T-cells, CD4+ T-cells, T helper (Th) 2-cells, Th 17-cells, CD8+ T-cells, CD4-CD8- T-cells, CD56+ natural killer (NK) cells, and CD14-CD16+ monocytes. Many of the changes were transient. Proportions of NK-cells and CD8+ T-cells increased, while the proportion of myeloid derived suppressor cells (MDSCs) reduced, and proportion of regulatory T-cells remained unchanged by exercise. Several associations were detected between cell mobilizations and disease state. For instance, tumor size correlated negatively with NK cell mobilization at E15, and progesterone receptor positivity correlated negatively with CD8+ T-cell mobilization.ConclusionThe findings show that the proportions of CD8+ T-cells and NK cells increased and the proportion of MDSCs proportion decreased in breast cancer patients after 30-minute exercise, suggesting a change in the profile of circulating immune cells towards more cytotoxic/anti-tumorigenic. The mobilization of some immune cells also appears to be related to the disease state.

Despite an abundance of evidence that exercise benefits cognition and mood, physical activity levels among older adults remain low, with time and inaccessibility posing major barriers. Interval stair climbing is an accessible time-efficient form of physical activity demonstrated to benefit cognition and mood in young adults, but effectiveness in older adults remains unknown. To address this, 28 older adults (Mage = 69.78 years, 16 females) undertook cognitive and mood assessments twice, 1 week apart, once preceded by interval stair climbing. A fairly large, albeit only marginally significant, effect size (η p 2 =.12) indicated improved cognition following the moderate- to high-intensity intervention; however, rather than improving mood, older adults reported feeling more tired (g = 0.51). These outcomes provide initial indications that this mode of exercise that can easily translate to naturalistic settings offers promise as an intervention strategy, but more research is needed to optimize the protocol to suit aged populations (ACTRN1261900169014). [ABSTRACT FROM AUTHOR]

Objective: The purpose of this study was to investigate the effects of different exercise intensities on postprandial lipemia (PHTG) and insulin resistance in healthy individuals. Methods: Participants were 10 adult males with normal fasting triglyceride (TG) concentrations (age = 34 ± 2.8 y, body mass = 72.9 ± 2.4 kg, fasting plasma TG = 1.36 ± 0.18 mmol/l, VO2max = 43.7 ± 3.0 ml/kg/min, fasting glucose = 5.2 ± 0.2 mmol/l and fasting Homeostatic Model Assessment for Insulin Resistance (HOMA2-IR) = 1.7 ± 0.3). In this study, each participant performed a control trial (Ctr, no exercise), and 3 exercise trials at 40 % (40%T), 60 % (60%T), and 70 % (70%T) of their VO2max. In the exercise trials, participant jogged on a treadmill for 1 h at a designated intensity. A fat-rich meal was consumed by each participant 12 h after exercise. Blood samples were taken at 0 h (before the meal), and 2 h, 4 h, 6 h, 8 h, and 24 h after the meal. The plasma TG, area score under TG concentration curve over an 8 h-period (TG tAUC) after the meal, and HOMA2-IR were analyzed. Results: Our results showed that at 2 h, 4 h, and 6 h after the meal, TG in all exercise trials were lower than Ctr (p

Acute exercise induces transient modifications in the tumor microenvironment and has been linked to reduced tumor growth along with increased infiltration of immune cells within the tumor in mouse models. In this study, we aimed to evaluate the impact of acute exercise before treatment administration on tumor growth in a mice model of MC38 colorectal cancer receiving an immune checkpoint inhibitor (ICI) and chemotherapy. Six-week-old mice injected with colorectal cancer cells (MC38) were randomized in 4 groups: control (CTRL), immuno-chemotherapy (TRT), exercise (EXE) and combined intervention (TRT/ EXE). Both TRT and TRT-EXE received ICI: anti-PD1-1 (1 injection/week) and capecitabine + oxaliplatin (5 times a week) for 1 week (experimentation 1), 3 weeks (experimentation 2). TRT-EXE and EXE groups were submitted to 50 minutes of treadmill exercise before each treatment administration. Over the protocol duration, tumor size has been monitored daily. Tumor growth and microenvironment parameters were measured after the intervention on Day 7 (D7) and Day 16 (D16). From day 4 to day 7, tumor volumes decreased in the EXE/ TRT group while remaining stable in the TRT group (p=0.0213). From day 7 until day 16 tumor volume decreased with no significant difference between TRT and TRT/EXE. At D7 the TRT/EXE group exhibited a higher total infiltrate T cell (p=0.0118) and CD8+ cytotoxic T cell (p=0.0031). At D16, tumor marker of apoptosis, vascular integrity and inflammation were not significantly different between TRT and TRT/EXE. Our main result was that acute exercise before immuno-chemotherapy administration significantly decreased early-phase tumor growth (D0 to D4). Additionally, exercise led to immune cell infiltration changes during the first week after exercise, while no significant molecular alterations in the tumor were observed 3 weeks after exercise. [ABSTRACT FROM AUTHOR]

Objectives: A systematic review and meta-analysis of studies of single exercise on core symptoms and executive function in adolescents with ADHD. Methods: Four databases were searched for studies of the effects of single exercise on core symptoms and executive functioning in adolescents with ADHD. Results: Thirteen studies were included, and a single session of exercise had small effect-size improvements in core symptoms and executive function in adolescents with ADHD: 10 to 13 year olds in the early adolescent–elementary school years and 18 to 24 year olds in the late adolescent–college years. Moderate-intensity continuous training, high-intensity interval training, single sessions of less than 30 minutes, and single sessions of 30 minutes and more significantly improved cycling training, attention, inhibition, substance use, and pre-study abstinence. Conclusions: A single session of exercise had an overall ameliorative effect on core symptoms and executive function in adolescents with ADHD. [ABSTRACT FROM AUTHOR]

Acute cardiovascular physical exercise improves cognitive performance, as evidenced by a reduction in reaction time (RT). However, the mechanistic understanding of how this occurs is elusive and has not been rigorously investigated in humans. Here, using positron emission tomography (PET) with [11C]raclopride, in a multi‐experiment study we investigated whether acute exercise releases endogenous dopamine (DA) in the brain. We hypothesized that acute exercise augments the brain DA system, and that RT improvement is correlated with this endogenous DA release. The PET study (Experiment 1: n = 16) demonstrated that acute physical exercise released endogenous DA, and that endogenous DA release was correlated with improvements in RT of the Go/No‐Go task. Thereafter, using two electrical muscle stimulation (EMS) studies (Experiments 2 and 3: n = 18 and 22 respectively), we investigated what triggers RT improvement. The EMS studies indicated that EMS with moderate arm cranking improved RT, but RT was not improved following EMS alone or EMS combined with no load arm cranking. The novel mechanistic findings from these experiments are: (1) endogenous DA appears to be an important neuromodulator for RT improvement and (2) RT is only altered when exercise is associated with central signals from higher brain centres. Our findings explain how humans rapidly alter their behaviour using neuromodulatory systems and have significant implications for promotion of cognitive health. Key points: Acute cardiovascular exercise improves cognitive performance, as evidenced by a reduction in reaction time (RT). However, the mechanistic understanding of how this occurs is elusive and has not been rigorously investigated in humans.Using the neurochemical specificity of [11C]raclopride positron emission tomography, we demonstrated that acute supine cycling released endogenous dopamine (DA), and that this release was correlated with improved RT.Additional electrical muscle stimulation studies demonstrated that peripherally driven muscle contractions (i.e. exercise) were insufficient to improve RT.The current study suggests that endogenous DA is an important neuromodulator for RT improvement, and that RT is only altered when exercise is associated with central signals from higher brain centres. [ABSTRACT FROM AUTHOR]

Objectives: Determine the effect of incorporating mindfulness‐based activities into the recovery intervals of high‐intensity interval training (HIIT) on mindfulness induction and subsequent executive function performance. Designs: A within‐subject crossover trial. Methods: Forty adults participated in two experimental conditions, including a 30‐min bout of HIIT involving mindfulness recovery intervals (Mindful) and a 30‐min bout of HIIT without mindfulness recovery intervals (Non‐mindful), on two separate days in counterbalanced order. Before and after each condition, participants completed the flanker task, switch‐flanker task, and n‐back task to measure inhibitory control, cognitive flexibility, and working memory, respectively. Results: A higher level of mindfulness state was observed following the Mindful condition than the Non‐mindful condition. Dispositional mindfulness was positively correlated with the level of the mindful state only during the Mindful condition but not the Non‐mindful condition. The switch‐flanker response accuracy was improved from the pretest to posttest during the Non‐mindful condition but remained unchanged over time during the Mindful condition. Time‐related improvements in the flanker and n‐back task outcomes were observed for both the Mindful and Non‐mindful conditions and did not differ between conditions. Conclusion: Although incorporating mindfulness‐based activities during the recovery intervals of HIIT successfully led to greater state‐related mindfulness, such a heightened mindful state did not correspond with additional modulation in inhibitory control and working memory performance while attenuating HIIT‐related positive changes in task performance requiring cognitive flexibility. [ABSTRACT FROM AUTHOR]

The purpose of this study was to investigate the effects of different exercise intensities on postprandial lipemia (PHTG) and insulin resistance in healthy individuals. Participants were 10 adult males with normal fasting triglyceride (TG) concentrations (age = 34 ± 2.8 y, body mass = 72.9 ± 2.4 kg, fasting plasma TG = 1.36 ± 0.18 mmol/l, VO 2max = 43.7 ± 3.0 ml/kg/min, fasting glucose = 5.2 ± 0.2 mmol/l and fasting Homeostatic Model Assessment for Insulin Resistance (HOMA2-IR) = 1.7 ± 0.3). In this study, each participant performed a control trial (Ctr, no exercise), and 3 exercise trials at 40 % (40%T), 60 % (60%T), and 70 % (70%T) of their VO 2max. In the exercise trials, participant jogged on a treadmill for 1 h at a designated intensity. A fat-rich meal was consumed by each participant 12 h after exercise. Blood samples were taken at 0 h (before the meal), and 2 h, 4 h, 6 h, 8 h, and 24 h after the meal. The plasma TG, area score under TG concentration curve over an 8 h-period (TG tAUC) after the meal, and HOMA2-IR were analyzed. Our results showed that at 2 h, 4 h, and 6 h after the meal, TG in all exercise trials were lower than Ctr (p < 0.05) but did not differ from each other. All the exercise trials were lower in TG tAUC scores than Ctr (p < 0.02), but differences were not observed among the exercise trials. In comparison to Ctr, a significant difference in HOMA2-IR in both 60 % T and 70 % T (p < 0.05 and p < 0.01, respectively) was observed, but not in 40 % T. The results suggest that exercising at low to moderate exercise intensity for 1 h sufficiently attenuates a fat meal induced PHTG. Moderate exercise intensity also effectively mitigates insulin resistance. [ABSTRACT FROM AUTHOR]

This meta-analysis summarizes experiments that have assessed quadriceps pain intensity (PI) during cycling in healthy individuals. Secondly, it tested the impact of eleven plausible moderators of that pain: data source, pain measure, participant sex and fitness, study purpose and comparison condition, analgesic intervention, and exercise task, duration, number of bouts, and intensity. Articles published before September 15, 2022 were found by searching PubMed, Web of Science, PsychInfo, SportDiscus, Science Direct, and Google Scholar. Inclusion criteria were (i) a randomized between-subjects design or a within-subjects crossover design, (ii) healthy participants without preexisting pain conditions, (iii) leg cycling on a stationary ergometer, and (iv) quadriceps PI measured during cycling. Study quality was assessed, Hedge's d effect sizes were computed, and a mixed effects model was used to generate a mean effect size (Δ). Moderators were chosen a priori to account for heterogeneity. A total of 95 effects were derived from 35 studies. A mixed effects model indicated the mean effect size (Δ) was 0.671 (95% CI = 0.442 to 0.899, z = 5.754, P < 0.001). Total heterogeneity was high in this model (τ2 = 0.942, I2 = 80.90%, H2 = 5.24). [ABSTRACT FROM AUTHOR]

Acute aerobic exercise has been shown to benefit inhibitory control; however, less attention has been devoted to the effects of varying intensity and duration with a predetermined exercise volume. The current study assessed the influence of three distinct exercise conditions, each equated with a predesignated exercise volume but varied in terms of exercise durations and intensities, on inhibitory control utilizing both behavioral and neuroelectric measures obtained among late‐middle‐aged and older adults. Thirty‐four adults (61.76 ± 0.80 years) completed three exercise conditions [i.e., a 30‐min low‐intensity exercise (LIE), a 20‐min moderate‐intensity exercise (MIE), and a 16‐min high‐intensity exercise (HIE)] and a non‐exercise reading control condition (CON) on separate days. The exercise volumes of LIE and HIE were designed to match the exercise volume of MIE. Following cessation of each condition, the Stroop task was performed while event‐related potentials were recorded. Improved behavioral performance (i.e., shorter response time, higher accuracy, and smaller interference scores) was observed after LIE, MIE, and HIE than CON (ps <.005). Additionally, whereas a larger P3b amplitude was only observed following MIE compared to CON (p <.01), larger N2 and smaller N450 amplitudes were observed following all three exercise conditions compared to CON (ps <.005). These findings suggested that while MIE may provide additional benefits for attentional resource allocation, exercise conditions volume matched to MIE resulted in superior inhibitory control, paralleled by modulations of the neural underpinnings of conflict monitoring/detection. Although previous research has examined the relationship between exercise intensity and duration on inhibitory control, our study presents a novel approach by examining the impact of varying exercise intensity and duration. Although moderate‐intensity exercise affected the neuroelectric activation via the P3b potential, all three exercise protocols resulted in similar impacts on the N2 and N450 potentials. These findings establish a foundation for designing optimal exercise protocols to maximize the cognitive and brain benefits of inhibitory control. [ABSTRACT FROM AUTHOR]

Background: Excessive production of salivary nitric oxide (s-NO) is a risk factor for oral diseases such as Sj¨ogren syndrome and periodontal disease. Although s-NO is known to be affected by exercise, it is unclear how the difference in exercise intensities affects the s-NO response. Objectives: The purpose of this study was to investigate the acute effect of different exercise intensities (high vs. low intensity) on s-NO production using a cross-over design. Methods: Five healthy male young adults (21.6 ± 0.9 years) performed two ergometer exercises for 30 min at different exercise intensities: 50% heart rate (HR)reserve (low-intensity condition) and 80% HRreserve (high-intensity condition). Saliva samples were collected before (pre) and after (post 0-h and post 1-h) exercises. Results: The s-NO concentration significantly increased (P < 0.05) after the high-intensity exercise (changes in post 0-h; +244 ± 53mol/L, post 1-h; +352 ± 58-mol/L), but the s-NO concentration did not change after the low-intensity exercise (-changes in post 0-h; +11 ± 37 -mol/L, post 1-h; +64 ± 69 -mol/L). Conclusions: This study reveals that s-NO production is dependent on exercise intensities, suggesting that low-intensity exercise can be possible without increasing the risk of oral diseases. [ABSTRACT FROM AUTHOR]

IntroductionPhysical activity influences psychological well-being. This study aimed to determine the impact of exercise intensity on psychological well-being and alterations in emotion-related brain functional connectivity (FC).MethodsTwenty young, healthy, trained athletes performed a low- and high-intensity interval exercise (LIIE and HIIE) as well as a control condition in a within-subject crossover design. Before and after each condition, Positive And Negative Affect Scale (PANAS) was assessed as well as resting-state functional MRI (rs-fMRI). Voxel-wise FC was examined for bilateral amygdala seed region to whole-brain and emotion-related anatomical regions (e.g., insula, temporal pole, precuneus). Data analyses were performed using linear mixed-effect models with fixed factors condition and time.ResultsThe PANAS Positive Affect scale showed a significant increase after LIIE and HIIE and a significant reduction in Negative Affect after the control condition. In rs-fMRI, no significant condition-by-time interactions were observed between the amygdala and whole brain. Amygdala-precuneus FC analysis showed an interaction effect, suggesting reduced post-exercise anticorrelation after the control condition, but stable, or even slightly enhanced anticorrelation for the exercise conditions, especially HIIE.DiscussionIn conclusion, both LIIE and HIIE had positive effects on mood and concomitant effects on amygdala-precuneus FC, particularly after HIIE. Although no significant correlations were found between amygdala-precuneus FC and PANAS, results should be discussed in the context of affective disorders in whom abnormal amygdala-precuneus FC has been observed.

Research findings reveal a relationship between acute bouts of exercise and procedural/declarative memory. Prior systematic reviews report small/moderate effects of acute exercise on episodic long-term declarative memory. A somewhat overlooked issue is the influence of exercise on specific types of episodic memory processing. The primary focus of this systematic review and meta-analysis was to evaluate the effects of acute bouts of exercise prior to, during, and following encoding on free-, cued-recall, and recognition episodic memory. PubMed, Scopus, and EBSCO databases were entered, and 42 experiments were subject to meta-analysis. Exercise prior to encoding improved memory (d = 0.23) and affected free-recall (d = 0.40) tests of memory more than cued-recall (d = 0.08) or recognition (d = −0.06) memory. Exercise following encoding improved memory (d = 0.33) and affected recognition (d = 0.62) memory more than free- (d = 0.19) or cued-recall (d = 0.14) memory. Exercise during encoding did not influence memory (d = −0.04). Moderator analyses revealed that exercise before encoding impacted memory differentially on the basis of age, exercise type, and test-timing. When exercise occurred after encoding, age and exercise type, but not timing of the test influenced memory performance. Exercise before and after encoding has selective effects on episodic memory. Additional experiments that evaluate how bouts of exercise influence memory encoding are warranted.Systematic review registrationPROSPERO, identifier CRD42020202784.

It is important that principles of laboratory-based studies with implications for academic performance be implemented in naturalistic learning environments to gauge their feasibility. Here, an adaptation of a laboratory-based study of exercise breaks during a single video lecture was implemented during large, in-person lectures at Ohio State University for the duration of a semester. The rationale for this approach was based on findings that research participants who took exercise breaks during a video lecture were more likely to be on task towards the end of the lecture and performed significantly better on a multiple choice exam. The current project had three goals: (1) Establish the feasibility of integrating student-led exercise breaks during in-person lectures in a large university setting (2) Provide practical guidelines for implementing exercise breaks during in-person lectures (3) Provide preliminary evidence of positive effects of exercise breaks in a higher-education setting. One to two student-led exercise breaks (5 min each) were implemented during each 80 min, in-person lecture for the duration of a semester in four upper level Psychology courses with student enrollment ranging from 20 to 93 students (total enrollment = 223 students). Students reported that the exercise breaks were a strength of the courses and a positive experience, including self-reported improvement in attention to lecture content. Self-reported quantitative data indicated that exercise breaks improved attention, increased course enjoyment, and enhanced peer engagement. Compared to other classes, the students preferred exercise breaks during lectures. The current approach establishes the feasibility of integrating exercise breaks in a large, in-person university lecture environment for the duration of a semester with preliminary data indicating a positive impact on attention, engagement, and enjoyment. Practical guidelines for implementing exercise breaks during in-person lectures are provided.

Purpose: The extent to which acute exercise improves executive function (EF) remains indeterminate. The purpose of this systematic review and meta-analysis was to determine the effect of acute ergometer cycling exercise on executive function (EF), including the potential moderating effects of exercise intensity and duration, EF task type, and EF task onset. Methods: We searched seven electronic research databases using cycling- and cognition-related terms. All 17 studies included were published in the last 10 years and comprised healthy participants aged 18–35 years who completed tasks assessing a variety of EFs before and after cycling exercise lasting 10–60 min. We analyzed 293 effect sizes obtained from 494 individuals (mean age = 22.07 ± 2.46 yrs). Additional analyses were performed, using averaged effect sizes for each separate study to examine the omnibus effect across studies. Results: There was a positive effect of acute ergometer cycling exercise on response time (RT) in 16 of 17 studies reviewed and a positive effect for response accuracy (RA) in 8 of 14 studies; three studies did not report RA data. Hedges’ g effect sizes [95% CI] for RT ranged from 0.06 [-0.45, 0.56] to 1.50 [0.58, 2.43] and for RA from −1.94 [-2.61, −1.28] to 1.03 [0.88, 1.19].Bouts of cycling completed at moderate intensities appear to have the greatest effect on RT (Hedges' g = 1.03 [0.88, 1.19]) but no significant effect on RA; bouts with durations of 21–30 min appear to offer the greatest benefits for both RT (Hedges' g = 0.77 [0.41, 1.13]) and RA (Hedges' g = 0.92 [0.31, 1.52]). Effect sizes were greatest for RT in inhibitory control tasks (Hedges' g = 0.91 [0.80, 1.03]) and for RT when EF tasks were completed immediately post-exercise (Hedges’ g = 1.11 [0.88, 1.33]). Findings were similar in the omnibus analyses: moderate-intensity bouts had the greatest effect on RT, SMD = 0.79 (95% CI [0.49, 1.08]), z = 5.20, p

Recent studies show positive effects of acute exercise on language learning in young adults with lower baseline learning abilities; however, this is yet to be investigated in older adults. This study investigated the acute effects of different exercise intensities on new word learning in healthy older adults with lower and higher baseline learning abilities. Sixty older adults (mean age = 66.4 (4.6); 43 females) performed either a single bout of stretching exercise, moderate-intensity continuous exercise, or high-intensity interval exercise followed by a word learning task. In lower baseline learners, between-group differences were observed on immediate new word recall success, with the moderate-intensity continuous exercise group performing better than the stretching group. These findings suggest immediate benefits of moderate-intensity continuous exercise that are limited to word learning performance of older adults with lower baseline learning abilities. Further investigation into underlying mechanisms could lead to a better understanding of individual differences in responding to acute exercise. [ABSTRACT FROM AUTHOR]

This article is an editorial that discusses the metabolic responses and adaptations to exercise. It highlights the importance of physical exercise in treating and preventing chronic diseases and emphasizes the need for regular physical activity, even in overweight and obese individuals. The editorial also mentions several studies that have examined the molecular mechanisms activated during exercise and recovery, the role of exercise in treating specific conditions such as osteoarthritis and lumbar disc herniation, and the use of metabolomics in sport science. Overall, the article provides valuable insights into the effects of exercise on metabolism and the potential therapeutic benefits of physical activity. [Extracted from the article]

Purpose The main aim of this research analyses acute PE based on AB and how it might have an exponential affect during the school day. Methods A total of 46 healthy schoolchildren (age = 10.75 ± 0.65 years) participated in this study, receiving a traditional lesson of 25 min during the assigned class followed by 10 min of a free-reading task (Control Condition) or 10 min of physical activity based on motor games (Active-Break Condition). Immediately following the assigned 10-min. intervention, the participants performed the Psychomotor Vigilance Task (PVT) then finally returned to perform the traditional lesson for the remaining 15 min. Significant differences were found in the PVT. Results Our results show the main effect of the Active-Break Condition group responding faster (365 ms) than the students in the Control Condition group (379 ms), F (1.45) = 24.18, p = 0.001, η 2 = 0.34. The present study demonstrated that a student’s vigilance performance changes after of AB of 10 min (compared to the Control Condition) and that AB improves the efficiency of vigilance in schoolchildren of 10–11 years. Conclusions Although limited, our results could help researchers and teachers more accurately apply AB to more properly improve their students’ vigilance. More studies with EEG analysis and neuroimaging are necessary to understand the effects of AB in young students.

Background and Study Aim. Cardiovascular parameters testing can be used by various modalities ranging from ground running to sophisticated computerized treadmills. The purpose of this study was to compare the acute effect of treadmill moderate-intensity exercise with arm crank exercise on autonomic cardiac function among adult males. Material and Methods. One hundred-twenty male participants participated in this study. They were randomly allocated to a treadmill exercise group with sixty participants and the other sixty participants allocated into an arm crank exercise group. Both groups performed exercises for forty minutes. Autonomic cardiac functions (heart rate variability - HRV), heartbeats, and arterial blood pressure) were determined with the help of Phillips DigiTrak XT Holter heart rate monitor, Polar® Grit X watch, and automatic sphygmomanometer. An independent t-test was used to compare the anthropometric data between both groups. One-way analysis of variance was used to determine the differences between treadmill exercise and arm crank for autonomic cardiac functions among adult males. Results. The HRV decreased significantly during treadmill exercise than arm crank exercise. Mean values of heartbeats (HR), systolic blood pressure (SBP), and rate pressure product (RPP) increased significantly during both exercises. In comparison, mean values of HRV parameters were reduced more significantly during treadmill exercise than arm crank. Mean values of the HR, SBP, and RPP increased significantly during treadmill exercise than arm crank exercise. Conclusion. The study's findings suggest that treadmill exercises are responsible for a greater significant reduction in HRV. The HR, SBP, PP, and RPP significantly increased during treadmill exercises than arm crank. This study suggests that when recommending exercise to any individual, the intensity and mode of exercise are crucial.

Obesity is a condition that can cause metabolic stress by activating the HPA axis, which impacts increasing stress levels characterized by increased cortisol secretion. The present research aims to investigate the impact of moderate-intensity acute exercise on decreasing cortisol levels among obese female students. A true-experimental method with a pretest-posttest control group design was utilized to conduct the study. A total of 20 female students between the ages of 20 and 23, with a BMI ranging from 25-28 kg/m2, voluntarily participated in the research. The participants were divided into two groups: control (n=10) and exercise (n=10) - the latter group being exposed to moderate-intensity acute exercise once as an intervention, with 40-minute sessions and an intensity level of 60-70% HRmax using the Treadmill Life Fitness equipment. The serum cortisol levels were measured through the ELISA 30 minutes pre-exercise and 6 hours post-exercise. The collected data were analyzed using an independent sample t-test with a 5% significance level. The study's findings will help compare the mean serum cortisol levels between the control and exercise groups. Based on the results of the study, it was found it can be concluded that moderate-intensity acute exercise carried out for 40 minutes/exercise session was effective in reducing serum cortisol levels in obese female students. We recommend exercise to overcome stress-related metabolic health problems in individuals with obesity.

Acute exercise induces transient modifications in the tumor microenvironment and has been linked to reduced tumor growth along with increased infiltration of immune cells within the tumor in mouse models. In this study, we aimed to evaluate the impact of acute exercise before treatment administration on tumor growth in a mice model of MC38 colorectal cancer receiving an immune checkpoint inhibitor (ICI) and chemotherapy. Six-week-old mice injected with colorectal cancer cells (MC38) were randomized in 4 groups: control (CTRL), immuno-chemotherapy (TRT), exercise (EXE) and combined intervention (TRT/EXE). Both TRT and TRT-EXE received ICI: anti-PD1-1 (1 injection/week) and capecitabine + oxaliplatin (5 times a week) for 1 week (experimentation 1), 3 weeks (experimentation 2). TRT-EXE and EXE groups were submitted to 50 minutes of treadmill exercise before each treatment administration. Over the protocol duration, tumor size has been monitored daily. Tumor growth and microenvironment parameters were measured after the intervention on Day 7 (D7) and Day 16 (D16). From day 4 to day 7, tumor volumes decreased in the EXE/TRT group while remaining stable in the TRT group (p=0.0213). From day 7 until day 16 tumor volume decreased with no significant difference between TRT and TRT/EXE. At D7 the TRT/EXE group exhibited a higher total infiltrate T cell (p=0.0118) and CD8+ cytotoxic T cell (p=0.0031). At D16, tumor marker of apoptosis, vascular integrity and inflammation were not significantly different between TRT and TRT/EXE. Our main result was that acute exercise before immuno-chemotherapy administration significantly decreased early-phase tumor growth (D0 to D4). Additionally, exercise led to immune cell infiltration changes during the first week after exercise, while no significant molecular alterations in the tumor were observed 3 weeks after exercise.