The Arabian-Nubian Shield (ANS) is a rapidly emerging world-class province for gold resources mainly in structurally-controlled quartz ± carbonate veins that are best classified as late Neoproterozoic orogenic gold deposits. Gold has been mined in the Eastern Desert of Egypt, in the northwestern part of the ANS, for >6000 years, that is since the times of the Pharaohs, but production prior to the 1900s was likely only about 25 t and mainly from alluvial workings. In the first half of the 1900s, about 7 t Au was recovered from the El Sid orogenic gold deposit. Today, Sukari is the single major producing mine in the Eastern Desert but many other significant gold occurrences are being actively explored. Formation of the ANS took place during closure of the Mozambique Ocean between the East and West Gondwana continental blocks. Ocean closure led to amalgamation of numerous ca. 870–625 Ma juvenile arc and back-arc igneous and sedimentary rock sequences, with many resulting terrane sutures marked by mafic-ultramafic ophiolitic assemblages and fragments. The 100 m.y. of orogeny beginning at ca. 650 Ma included crustal shortening, lithospheric reworking, escape tectonics, and eventual orogenic collapse. Peak metamorphism was reached in different parts and depths of the orogen diachronously between 620 and 585 Ma, magmatism was widespread during 650–580 Ma, and rapid exhumation of the metamorphosed rocks and mid-crustal intrusions took place from ca. 600 to 580 Ma. Regional fault sets that controlled much of the gold occurrences were related to initial transpression by oblique convergence between the arcs and associated with subsequent sinistral shearing reported as overlapping the exhumation. Because existing geological data are not adequate to fully evaluate the overall terrane history, we have subdivided the Eastern Desert into nine structural blocks, rather than arc terranes, based commonly on bounding shear zones and major faults. The greatest abundance of gold deposits is associated with the NW-trending Najd Fault System that comprises many splays throughout the blocks in the Central Eastern Desert that underwent episodes of shearing at ca. 640–570 Ma. Important deposits are also notably widespread along reactivated east-west thrust faults in the Allaqi-Sol Hamed block of the South Eastern Desert, with significant shearing at 610–580 Ma. Sulfide mineralogy of the Eastern Desert gold-bearing veins is dominated by pyrite, arsenopyrite, and (or) pyrrhotite, in addition to subordinate chalcopyrite, sphalerite, galena and tetrahedrite as well as alteration minerals that include white mica, chlorite, and carbonate, are those typical of orogenic gold deposits. Many gold occurrences are located along sheared margins to granitic intrusions or along contacts between different lithologies; sheared silica- and carbonate-altered ultramafic rocks along many fault zones are particularly widely associated with many of the gold occurrences. Ore-forming fluids were generally low-salinity aqueous-carbonic with most measured δ18O of mineralized quartz ranging from 8‰ to 15‰, δ13C for associated carbonate from −10‰ to −1‰, and δ34S for ore-related sulfides varying between −5 and +10‰, but much more consistent for individual occurrences or deposits. Gold was deposited at temperatures of generally between 250° and 370 °C, depending on location, and largely variable pressures. The few obtained absolute dates on ore formation, from the Fawakhir and Atalla deposits in the Central Eastern Desert, indicate that at least some of the mineralization was formed at ca. 600 Ma. Orogenic gold formed after the cessation of arc-terrane accretion in the ANS and during a period in which most of the shield became established with a 30–40 km-thick continental crust and underwent a transition from compressional/transpressional terrane accretion to post-amalgamation transtensional shearing. This also was marked by a petrogenetic transition from pre- to syn-accretionary, arc-related calc-alkaline I-type magmatism to late- or post-tectonic A-type magmatism within the newly formed shield. Concurrently, the Eastern Desert was affected by widespread crustal flow of aqueous-carbonic fluids, particularly on the through-going, extensive strike-slip shears of the Najd Fault System. Gold and sulfide minerals were deposited in the Eastern Desert shallow and middle crust coevally with rapid terrane exhumation, during changes in fluid chemistry associated with pressure cycling and multiple vein quartz precipitation. Unlabelled Image • Available information on gold occurrences in the Eastern Desert of Egypt is reviewed, assessed and thoroughly discussed. • New ideas of the genesis and controls of the scattered gold occurrences in the shield are herein presented and detailed. • Orogenic gold in the Eastern Desert formed after the cessation of arc-terrane accretion and post-peak metamorphism. • Transition from subduction-related to within-plate magmatism was concomitant with widespread aqueous-carbonic fluid flow. • Significant orogenic gold mineralization formed at ca. 600 Ma, concurrent with crustal exhumation and extensive shearing. [ABSTRACT FROM AUTHOR]