Search

Your search keyword '"Zwijnenburg, D A"' showing total 12 results
Start Over Author "Zwijnenburg, D A"
12 results on '"Zwijnenburg, D A"'

3. A Common Genomic Denominator for Neuroblastoma and Differentiated Thyroid Carcinoma? A Case Series in Children

Author

Afd Pharmaceutics, Pharmaceutics, Clement, S. C., Koster, J., Kuiper, R. P., Tytgat, G. A.M., Ebus, M. E., Schild, L., Gilissen, C., Zwijnenburg, D. A., Versteeg, R., Molenaar, J. J., van Santen, H. M., Afd Pharmaceutics, Pharmaceutics, Clement, S. C., Koster, J., Kuiper, R. P., Tytgat, G. A.M., Ebus, M. E., Schild, L., Gilissen, C., Zwijnenburg, D. A., Versteeg, R., Molenaar, J. J., and van Santen, H. M.

Published
2022

4. A Common Genomic Denominator for Neuroblastoma and Differentiated Thyroid Carcinoma?: A Case Series in Children

Author

Endocrinologie onderzoek, Cancer, Genetica, Brain, Child Health, Endocrinologie patientenzorg, Clement, S. C., Koster, J., Kuiper, R. P., Tytgat, G. A.M., Ebus, M. E., Schild, L., Gilissen, C., Zwijnenburg, D. A., Versteeg, R., Molenaar, J. J., van Santen, H. M., Endocrinologie onderzoek, Cancer, Genetica, Brain, Child Health, Endocrinologie patientenzorg, Clement, S. C., Koster, J., Kuiper, R. P., Tytgat, G. A.M., Ebus, M. E., Schild, L., Gilissen, C., Zwijnenburg, D. A., Versteeg, R., Molenaar, J. J., and van Santen, H. M.

Published
2022

6. Collagen-rich stroma in aggressive colon tumors induces mesenchymal gene expression and tumor cell invasion

Author

MS CGO, Circulatory Health, Cancer, Regenerative Medicine and Stem Cells, CMM Groep Snippert, CMM Groep Bos, CTI CFF, Vellinga, T T, den Uil, S, Rinkes, IHB, Marvin, D, Ponsioen, B, Alvarez-Varela, A, Fatrai, S, Scheele, C, Zwijnenburg, D A, Snippert, H, Vermeulen, L, Medema, J P, Stockmann, H B, Koster, J, Fijneman, R J A, de Rooij, J, Kranenburg, O, MS CGO, Circulatory Health, Cancer, Regenerative Medicine and Stem Cells, CMM Groep Snippert, CMM Groep Bos, CTI CFF, Vellinga, T T, den Uil, S, Rinkes, IHB, Marvin, D, Ponsioen, B, Alvarez-Varela, A, Fatrai, S, Scheele, C, Zwijnenburg, D A, Snippert, H, Vermeulen, L, Medema, J P, Stockmann, H B, Koster, J, Fijneman, R J A, de Rooij, J, and Kranenburg, O

Published
2016

7. Sequencing of neuroblastoma identifies chromothripsis and defects in neuritogenesis genes

Author

Molenaar, J. (Jan), Koster, J. (Jan), Zwijnenburg, D. (Danny), Sluis, P. (Peter) van, Valentijn, L.J. (Linda), Ploeg, I. (Ida) van der, Hamdi, M. (Mohamed), Nes, J. (Johan) van, Westerman, B.A. (Bart), Arkel, J. (Jennemiek) van, Ebus, M.E., Haneveld, F. (Franciska), Lakeman, A. (Arjan), Schild, L. (Linda), Molenaar, P. (Piet), Stroeken, P. (Peter), Noesel, M.M. (Max) van, Øra, I. (Ingrid), Santo, J.P. (James) di, Caron, H.N. (Huib), Westerhout, E.M. (Ellen), Versteeg, R. (Rogier), Molenaar, J. (Jan), Koster, J. (Jan), Zwijnenburg, D. (Danny), Sluis, P. (Peter) van, Valentijn, L.J. (Linda), Ploeg, I. (Ida) van der, Hamdi, M. (Mohamed), Nes, J. (Johan) van, Westerman, B.A. (Bart), Arkel, J. (Jennemiek) van, Ebus, M.E., Haneveld, F. (Franciska), Lakeman, A. (Arjan), Schild, L. (Linda), Molenaar, P. (Piet), Stroeken, P. (Peter), Noesel, M.M. (Max) van, Øra, I. (Ingrid), Santo, J.P. (James) di, Caron, H.N. (Huib), Westerhout, E.M. (Ellen), and Versteeg, R. (Rogier)

Abstract

Neuroblastoma is a childhood tumour of the peripheral sympathetic nervous system. The pathogenesis has for a long time been quite enigmatic, as only very few gene defects were identified in this often lethal tumour. Frequently detected gene alterations are limited to MYCN amplification (20%) and ALK activations (7%). Here we present a whole-genome sequence analysis of 87 neuroblastoma of all stages. Few recurrent amino-acid-changing mutations were found. In contrast, analysis of structural defects identified a local shredding of chromosomes, known as chromothripsis, in 18% of high-stage neuroblastoma. These tumours are associated with a poor outcome. Structural alterations recurrently affected ODZ3, PTPRD and CSMD1, which are involved in neuronal growth cone stabilization. In addition, ATRX, TIAM1 and a series of regulators of the Rac/Rho pathway were mutated, further implicating defects in neuritogenesis in neuroblastoma. Most tumours with defects in these genes were aggressive high-stage neuroblastomas, but did not carry MYCN amplifications. The genomic landscape of neuroblastoma therefore reveals two novel molecular defects, chromothripsis and neuritogenesis gene alterations, which frequently occur in high-risk tumours.

Published
2012
Full Text
View/download PDF

8. Lectures

Author

Chen, D. S., primary, Feltquate, D. M., additional, Smothers, F., additional, Hoos, A., additional, Langermann, S., additional, Marshall, S., additional, May, R., additional, Fleming, M., additional, Hodi, F. S., additional, Senderowicz, A., additional, Wiman, K. G., additional, de Dosso, S., additional, Fiedler, W., additional, Gianni, L., additional, Cresta, S., additional, Schulze-Bergkamen, H. B., additional, Gurrieri, L., additional, Salzberg, M., additional, Dietrich, B., additional, Danielczyk, A., additional, Baumeister, H., additional, Goletz, S., additional, Sessa, C., additional, Strumberg, D., additional, Schultheis, B., additional, Santel, A., additional, Gebhardt, F., additional, Meyer-Sabellek, W., additional, Keil, O., additional, Giese, K., additional, Kaufmann, J., additional, Maio, M., additional, Choy, G., additional, Covre, A., additional, Parisi, G., additional, Nicolay, H., additional, Fratta, E., additional, Fonsatti, E., additional, Sigalotti, L., additional, Coral, S., additional, Taverna, P., additional, Azab, M., additional, Deutsch, E., additional, Lepechoux, C., additional, Pignon, J. P., additional, Tao, Y. T., additional, Rivera, S., additional, Bourgier, B. C., additional, Angokai, M., additional, Bahleda, R., additional, Slimane, K., additional, Angevin, E., additional, Besse, B. B., additional, Soria, J. C., additional, Dragnev, K., additional, Beumer, J. H., additional, Anyang, B., additional, Ma, T., additional, Galimberti, F., additional, Erkmen, C. P., additional, Nugent, W., additional, Rigas, J., additional, Abraham, K., additional, Johnstone, D., additional, Memoli, V., additional, Dmitrovsky, E., additional, Voest, E. E., additional, Siu, L., additional, Janku, F., additional, Tsimberidou, A., additional, Kurzrock, R., additional, Tabernero, J., additional, Rodon, J., additional, Berger, R., additional, Onn, A., additional, Batist, G., additional, Bresson, C., additional, Lazar, V., additional, Molenaar, J. J., additional, Koster, J., additional, Ebus, M., additional, Zwijnenburg, D. A., additional, van Sluis, P., additional, Lamers, F., additional, Schild, L., additional, van der Ploeg, I., additional, Caron, H. N., additional, Versteeg, R., additional, Pouyssegur, J., additional, Marchiq, I., additional, Chiche, J., additional, Roux, D., additional, Le Floch, R., additional, Critchlow, S. E., additional, Wooster, R. F., additional, Agresta, S., additional, Yen, K. E., additional, Janne, P. A., additional, Plummer, E. R., additional, Trinchieri, G., additional, Ellis, L., additional, Chan, S. L., additional, Yeo, W., additional, Chan, A. T., additional, Mouliere, F., additional, El Messaoudi, S., additional, Gongora, C., additional, Lamy, P. J., additional, del Rio, M., additional, Lopez-Crapez, E., additional, Gillet, B., additional, Mathonnet, M., additional, Pezet, D., additional, Ychou, M., additional, Thierry, A. R., additional, Ribrag, V., additional, Vainchenker, W., additional, Constantinescu, S., additional, Keilhack, H., additional, Umelo, I. A., additional, Noeparast, A., additional, Chen, G., additional, Renard, M., additional, Geers, C., additional, Vansteenkiste, J., additional, Teugels, E., additional, de Greve, J., additional, Rixe, O., additional, Qi, X., additional, Chu, Z., additional, Celerier, J., additional, Leconte, L., additional, Minet, N., additional, Pakradouni, J., additional, Kaur, B., additional, Cuttitta, F., additional, Wagner, A. J., additional, Zhang, Y. X., additional, Sicinska, E., additional, Czaplinski, J. T., additional, Remillard, S. P., additional, Demetri, G. D., additional, Weng, S., additional, Debussche, L., additional, Agoni, L., additional, Reddy, E. P., additional, Guha, C., additional, Silence, K., additional, Thibault, A., additional, de Haard, H., additional, Dreier, T., additional, Ulrichts, P., additional, Moshir, M., additional, Gabriels, S., additional, Luo, J., additional, Carter, C., additional, Rajan, A., additional, Khozin, S., additional, Thomas, A., additional, Lopez-Chavez, A., additional, Brzezniak, C., additional, Doyle, L., additional, Keen, C., additional, Manu, M., additional, Raffeld, M., additional, Giaccone, G., additional, Lutzker, S., additional, Melief, J. M., additional, Eckhardt, S. G., additional, Trusolino, L., additional, Migliardi, G., additional, Zanella, E. R., additional, Cottino, F., additional, Galimi, F., additional, Sassi, F., additional, Marsoni, S., additional, Comoglio, P. M., additional, Bertotti, A., additional, Hidalgo, M., additional, Weroha, S. J., additional, Haluska, P., additional, Becker, M. A., additional, Harrington, S. C., additional, Goodman, K. M., additional, Gonzalez, S. E., additional, al Hilli, M., additional, Butler, K. A., additional, Kalli, K. R., additional, Oberg, A. L., additional, Huijbers, I. J., additional, Bin Ali, R., additional, Pritchard, C., additional, Cozijnsen, M., additional, Proost, N., additional, Song, J. Y., additional, Krimpenfort, P., additional, Michalak, E., additional, Jonkers, J., additional, Berns, A., additional, Banerji, U., additional, Stewart, A., additional, Thavasu, P., additional, Banerjee, S., additional, and Kaye, S. B., additional

Published
2013
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results