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15 results on '"Zwiers, Antonie"'

1. Interleukin 12

Author

Dieckman, Tessa, Zwiers, Antonie, Kraal, Georg, Bouma, Gerd, and Parnham, Michael J., editor

Published
2016
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2. Interleukin 12

Author

Dieckman, Tessa, primary, Zwiers, Antonie, additional, Kraal, Georg, additional, and Bouma, Gerd, additional

Published
2014
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3. Cytotoxic T Lymphocyte Antigen–4 +49A/G polymorphism does not affect susceptibility to autoimmune hepatitis

Author

van Gerven, Nicole M. F., de Boer, Ynto S., Zwiers, Antonie, van Hoek, Bart, van Erpecum, Karel J., Beuers, Ulrich, van Buuren, Henk R., Drenth, Joost P. H., den Ouden, Jannie W., Verdonk, Robert C., Koek, Ger H., Brouwer, Johannes T., Guichelaar, Maureen M. J., Vrolijk, Jan M., Kraal, G., Mulder, Chris J. J., van Nieuwkerk, Carin. M. J., and Bouma, Gerd

Published
2013
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5. Dendritic Cell Migration to Skin-Draining Lymph Nodes Is Controlled by Dermatan Sulfate and Determines Adaptive Immunity Magnitude

Author

Nadafi, Reza, primary, Koning, Jasper J., additional, Veninga, Henrike, additional, Stachtea, Xanthi N., additional, Konijn, Tanja, additional, Zwiers, Antonie, additional, Malmström, Anders, additional, den Haan, Joke M. M., additional, Mebius, Reina E., additional, Maccarana, Marco, additional, and Reijmers, Rogier M., additional

Published
2018
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6. Sa1677 HLA-DRB1*0301 and HLA-DRB1*0401 Modify the Presentation and Outcome in Autoimmune Hepatitis Type-1

Author

van Gerven, Nicole M., primary, de Boer, Ynto S., additional, Zwiers, Antonie, additional, Verwer, Bart, additional, Drenth, Joost P., additional, van Hoek, Bart, additional, Van Erpecum, Karel J., additional, Beuers, Ulrich, additional, van Buuren, Henk R., additional, den Ouden, Jannie W., additional, Verdonk, Robert, additional, Koek, Ger H., additional, Brouwer, Johannes, additional, Guichelaar, Maureen, additional, Vrolijk, Jan, additional, Coenraad, Minneke, additional, Kraal, Georg, additional, Mulder, Chris J., additional, van Nieuwkerk, Carin, additional, Verspaget, Hein W., additional, Bloemena, Elisabeth, additional, Kumar, Vinod, additional, Zhernakova, Alexandra, additional, Wijmenga, Cisca, additional, Franke, Lude, additional, and Bouma, Gerd, additional

Published
2015
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7. Genome-Wide Association Study Identifies Variants Associated With Autoimmune Hepatitis Type 1

Author

de Boer, Ynto S., primary, van Gerven, Nicole M.F., additional, Zwiers, Antonie, additional, Verwer, Bart J., additional, van Hoek, Bart, additional, van Erpecum, Karel J., additional, Beuers, Ulrich, additional, van Buuren, Henk R., additional, Drenth, Joost P.H., additional, den Ouden, Jannie W., additional, Verdonk, Robert C., additional, Koek, Ger H., additional, Brouwer, Johannes T., additional, Guichelaar, Maureen M.J., additional, Vrolijk, Jan M., additional, Kraal, Georg, additional, Mulder, Chris J.J., additional, van Nieuwkerk, Carin M.J., additional, Fischer, Janett, additional, Berg, Thomas, additional, Stickel, Felix, additional, Sarrazin, Christoph, additional, Schramm, Christoph, additional, Lohse, Ansgar W., additional, Weiler-Normann, Christina, additional, Lerch, Markus M., additional, Nauck, Matthias, additional, Völzke, Henry, additional, Homuth, Georg, additional, Bloemena, Elisabeth, additional, Verspaget, Hein W., additional, Kumar, Vinod, additional, Zhernakova, Alexandra, additional, Wijmenga, Cisca, additional, Franke, Lude, additional, and Bouma, Gerd, additional

Published
2014
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13. Cytotoxic T Lymphocyte Antigen-4 +49A/G polymorphism does not affect susceptibility to autoimmune hepatitis.

Author

Gerven, Nicole M. F., Boer, Ynto S., Zwiers, Antonie, Hoek, Bart, Erpecum, Karel J., Beuers, Ulrich, Buuren, Henk R., Drenth, Joost P. H., den Ouden, Jannie W., Verdonk, Robert C., Koek, Ger H., Brouwer, Johannes T., Guichelaar, Maureen M. J., Vrolijk, Jan M., Kraal, G., Mulder, Chris J. J., Nieuwkerk, Carin. M. J., and Bouma, Gerd

Subjects
CYTOTOXIC T cells, LYMPHOCYTES, ANTIGENS, GENETIC polymorphisms, CHRONIC active hepatitis
Abstract

Background & Aims Single nucleotide polymorphisms ( SNP) in the Cytotoxic T lymphocyte antigen-4 gene ( CTLA-4) have been associated with several autoimmune diseases including autoimmune Hepatitis ( AIH). In this chronic idiopathic inflammatory liver disease, conflicting results have been reported on the association with a SNP at position +49 in the CTLA-4 gene in small patient cohorts. Here, we established the role of this SNP in a sufficiently large cohort of AIH patients. Methods The study population consisted of 672 AIH patients derived from academic and regional hospitals in the Netherlands and was compared with 500 controls selected from the 'Genome of the Netherlands' project cohort. Genotype frequencies were assessed by PCR for patients and by whole genome sequencing for controls. Results No significant differences in allele frequencies were found between patients and controls (G Allele: 40% vs 39%, P = 0.7). Similarly, no significant differences in genotype frequencies between patients and controls were found. Finally, there was no relation between disease activity and the G allele or AG and GG genotypes. Conclusion The Cytotoxic T Lymphocyte Antigen-4 +49 A/G polymorphism does not represent a major susceptibility risk allele for AIH in Caucasians and is not associated with disease severity at presentation. [ABSTRACT FROM AUTHOR]

Published
2013
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15. Positive coeliac serology in irritable bowel syndrome patients with normal duodenal biopsies: Video capsule endoscopy findings and HLA-DQ typing may affect clinical management.

Author

Adler SN, Jacob H, Lijovetzky G, Mulder CJ, and Zwiers A

Subjects
Adolescent, Adult, Aged, Capsule Endoscopy, Female, Gliadin immunology, Histocompatibility Testing, Humans, Irritable Bowel Syndrome immunology, Male, Middle Aged, Transglutaminases immunology, Duodenum pathology, Immunoglobulin A blood, Immunoglobulin G blood, Irritable Bowel Syndrome blood, Irritable Bowel Syndrome pathology
Abstract

Objectives: To investigate a group of IBS patients (Rome criteria) with positive coeliac serology (EMA, TTG, IgG or IgA AGA) and normal small bowel biopsies. Video capsule endoscopy (VCE) findings of the small bowell were compared with DQ-typing., Methods: Twenty-two patients with chronic abdominal pain (with or without diarrhea) and at least one positive result of any of the coeliac serological markers (AGA, TTG, EMA) and normal duodenal biopsy were enrolled and underwent VCE. Twelve healthy volunteers with VCE served as control group. Coeliac related HLA DQ2 or DQ8 markers were determined., Results: 12/ 22 (55%) patients had small bowel abnormalities with VCE. No mucosal abnormalities were recognized in the control group (p = 0.002). Inflammatory changes were classified as moderate or pronounced. Eight patients (36%) had moderate changes and four patients (18%) demonstrated pronounced changes. Only 6 of the 21 IBS patients were positive for DQ2 and/or DQ8., Conclusions: The patients in this study fulfilled the diagnostic Rome criteria for Irritable Bowel Syndrome. We suggest that patients with positive coeliac serology and normal duodenal biopsies should undergo HLA typing. In patients positive for DQ2 and/or DQ8, a VCE should be performed. Patients with mucosal abnormalities compatible with CD should be considered as a group distinct from IBS patients and could be tested with gluten challenge or treated with a gluten free diet.

Published
2006

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