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3. Gehirn, Gesichtsschädel und Hals

Author

von Kummer, R., Müller, A., Staudt, M., Grodd, W., Mader, I., Brückmann, H., Reith, W., Rodiek, S. O., Yousry, T. A., Seelos, K. C., Steinborn, M., Schubiger, O., Hosten, N., Zwicker, C., Langer, M., Fürst, G., Berg, J., Vogl, T. J., Gademann, G., Reiser, Maximilian, editor, and Semmler, Wolfhard, editor

Published
2002
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5. Hirn, Gesichtsschädel und Hals

Author

von Kummer, R., Grodd, W., Voigt, K., Thron, A., Brückmann, H., Rodiek, S. O., Yousry, T., Seelos, K. C., Schubiger, O., Hosten, N., Zwicker, C., Langer, M., Mödder, U., Fürst, G., Vogl, T. J., Gademann, G., Reiser, Maximilian, editor, and Semmler, Wolfhard, editor

Published
1997
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20. Correction: E. coli Nissle 1917 is a safe mucosal delivery vector for a birch-grass pollen chimera to prevent allergic poly-sensitization

Author

Sarate, P., Heinl, S., Poiret, S., Drinić, M., Zwicker, C., Schabussova, I., Daniel, C., Wiedermann, U., Medizinische Universität Wien = Medical University of Vienna, Universität für Bodenkultur Wien = University of Natural Resources and Life [Vienne, Autriche] (BOKU), Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 (CIIL), Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Centre National de la Recherche Scientifique (CNRS), We gratefully acknowledge funding from the Austrian Science Fund SFB F46 and DK MCCA W1248-B30, OeAD-GmbH grants (FR13/2016) and from the Amadeus partnership Hubert Curein French and Austrian program., Daniel, Catherine, University of Natural Resources and Life Sciences (BOKU), Centre National de la Recherche Scientifique (CNRS)-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Université de Lille-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Pasteur de Lille, and Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)

Subjects
[SDV] Life Sciences [q-bio], 0303 health sciences, 03 medical and health sciences, 0302 clinical medicine, [SDV]Life Sciences [q-bio], Immunology, Immunology and Allergy, ComputingMilieux_MISCELLANEOUS, 030304 developmental biology, 030215 immunology, 3. Good health
Abstract

Following the publication of this article, the authors have requested that the Acknowledgements section be amended to include the financing source of the study. The correct Acknowledgments should be as follows: We gratefully acknowledge funding from the Austrian Science Fund SFB F46 and DK MCCA W1248-B30, OeAD-GmbH grants (FR13/2016) and from the Amadeus partnership Hubert Curein French and Austrian program. We thank the BioImaging Center of Lille (Frank Lafont) for the use of the IVIS Lumina XR. We gratefully thank Katharina Ambroz, Elke Korb, Karin Baier, Erika Garner-Spitzer, Joshua Tobias, Gwenaëlle Verbrugghe, and Jéremy Desramaut for their technical assistance and helpful discussions.

Published
2018

21. E. coli Nissle 1917 is a safe mucosal delivery vector for a birch-grass pollen chimera to prevent allergic poly-sensitization

Author

Sarate, P., Heinl, S., Poiret, S., Drinić, M., Zwicker, C., Schabussova, I., Daniel, C., Wiedermann, U., Medizinische Universität Wien = Medical University of Vienna, Universität für Bodenkultur Wien = University of Natural Resources and Life [Vienne, Autriche] (BOKU), Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 (CIIL), Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Centre National de la Recherche Scientifique (CNRS), We gratefully acknowledge funding from the Austrian Science Fund SFB F46 and DK MCCA, OeAD-GmbH grants (FR13/2016) and from the Amadeus partnership Hubert Curein French and Austrian program., Daniel, Catherine, University of Natural Resources and Life Sciences (BOKU), Centre National de la Recherche Scientifique (CNRS)-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Université de Lille-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Pasteur de Lille, and Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)

Subjects
[SDV.MHEP.PSR] Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract, [SDV.IMM.ALL]Life Sciences [q-bio]/Immunology/Allergology, [SDV.MHEP.PSR]Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract, [SDV.IMM.ALL] Life Sciences [q-bio]/Immunology/Allergology
Abstract

International audience; Allergic poly-sensitization affects a large number of allergic patients and poses a great challenge for their treatment. In this study we evaluated the effects of the probiotic Escherichia coli Nissle 1917 (EcN) expressing a birch and grass pollen allergen chimera ‘Bet v 1, Phl p 1 and Phl p 5’ (EcN-Chim) on allergy prevention after oral or intranasal application in poly-sensitized mice. In contrast to oral application, intranasal pretreatment with EcN-Chim prior to poly-sensitization led to a significant reduction of lung inflammation (eosinophils, IL-5, and IL-13 in bronchoalveolar lavage) along with suppressed levels of allergen-specific serum IgE. The suppression was associated with increased levels of allergen-specific IgA in lungs and serum IgG2a along with increased Foxp3, TGF-β, and IL-10 mRNA in bronchial lymph nodes. In vitro EcN induced high levels of IL-10 and IL-6 in both lung and intestinal epithelial cells. Importantly, using in vivo imaging techniques we demonstrated that intranasally applied EcN do not permanently colonize nose, lung, and gut and this strain might therefore be a safe delivery vector against allergy in humans. In conclusion, our data show that intranasal application of recombinant EcN expressing a multiallergen chimera presents a novel and promising treatment strategy for prevention of allergic poly-sensitization.

Published
2018

25. E. coliNissle 1917 is a safe mucosal delivery vector for a birch-grass pollen chimera to prevent allergic poly-sensitization

Author

Sarate, P. J., Heinl, S., Poiret, S., Drinic, M., Zwicker, C., Schabussova, I., Daniel, C., and Wiedermann, U.

Abstract

Allergic poly-sensitization affects a large number of allergic patients and poses a great challenge for their treatment. In this study we evaluated the effects of the probiotic Escherichia coliNissle 1917 (EcN) expressing a birch and grass pollen allergen chimera ‘Bet v 1, Phl p 1 and Phl p 5’ (EcN-Chim) on allergy prevention after oral or intranasal application in poly-sensitized mice. In contrast to oral application, intranasal pretreatment with EcN-Chim prior to poly-sensitization led to a significant reduction of lung inflammation (eosinophils, IL-5, and IL-13 in bronchoalveolar lavage) along with suppressed levels of allergen-specific serum IgE. The suppression was associated with increased levels of allergen-specific IgA in lungs and serum IgG2a along with increased Foxp3, TGF-ß, and IL-10 mRNA in bronchial lymph nodes. In vitro EcN induced high levels of IL-10 and IL-6 in both lung and intestinal epithelial cells. Importantly, using in vivo imaging techniques we demonstrated that intranasally applied EcN do not permanently colonize nose, lung, and gut and this strain might therefore be a safe delivery vector against allergy in humans. In conclusion, our data show that intranasal application of recombinant EcN expressing a multiallergen chimera presents a novel and promising treatment strategy for prevention of allergic poly-sensitization.

Published
2019
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26. Robots Assisting in the Packaging Industry

Author

Wallhoff, F., Blume, J., Bannat, A., Appleton, B., Rösel, W., Zwicker, C., Zäh, M., Reinhart, G., Pichler, A., Ferrara, P., Behrndt, R., and Lehrstuhl für Mensch-Maschine-Kommunikation

Subjects
ddc
Published
2011

34. Layer-specific analysis of myocardial deformation for assessment of infarct transmurality: comparison of strain-encoded cardiovascular magnetic resonance with 2D speckle tracking echocardiography

Author

Altiok, E., primary, Neizel, M., additional, Tiemann, S., additional, Krass, V., additional, Becker, M., additional, Zwicker, C., additional, Koos, R., additional, Kelm, M., additional, Kraemer, N., additional, Schoth, F., additional, Marx, N., additional, and Hoffmann, R., additional

Published
2012
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