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5. Poster Session: Right ventricular systolic function

Author

Altman, M., primary, Bergerot, C., additional, Thibault, H., additional, Aussoleil, A., additional, Skuldadt Davidsen, E., additional, Barthelet, M., additional, Derumeaux, G. A., additional, Grapsa, J., additional, Zimbarra Cabrita, I., additional, Afilalo, J., additional, Paschou, S., additional, Dawson, D., additional, Durighel, G., additional, O'regan, D., additional, Howard, L., additional, Gibbs, J., additional, Nihoyannopoulos, P., additional, Morenate Navio, M., additional, Mesa Rubio, M., additional, Ortega, M. D., additional, Ruiz Ortiz, M., additional, Castillo Bernal, F., additional, Del Pino, C. L., additional, Toledano, F., additional, Alvarez-Ossorio, M. P., additional, Ojeda Pineda, S., additional, Lezo Cruz-Conde, J. S. D., additional, Jasaityte, R., additional, Claus, P., additional, Teske, A., additional, Herbots, L., additional, Verheyden, B., additional, Rademakers, F., additional, D'hooge, J., additional, Tocchetti, C. G., additional, Coppola, C., additional, Rea, D., additional, Quintavalle, C., additional, Guarino, L., additional, Castaldo, N., additional, De Lorenzo, C., additional, Condorelli, G., additional, Arra, C., additional, Maurea, N., additional, Voilliot, D., additional, Huttin, O., additional, Camara, Y., additional, Djaballah, W., additional, Carillo, S., additional, Zinzius, P., additional, Sellal, J., additional, Angioi, M., additional, Juilliere, Y., additional, Selton-Suty, C., additional, Dobrowolski, P., additional, Klisiewicz, A., additional, Florczak, E., additional, Prejbisz, A., additional, Szwench, E., additional, Rybicka, J., additional, Januszewicz, A., additional, Hoffman, P., additional, Jurado Roman, A., additional, De Dios Perez, S., additional, De Nicolas, J. M. M., additional, Diaz Anton, B., additional, Rubio Alonso, B., additional, Martin Asenjo, R., additional, Mayordomo Gomez, S., additional, Villagraz Tecedor, L., additional, Blazquez, L., additional, De Meneses, R. T., additional, Bernard, A., additional, Hernandez, A. I., additional, Reynaud, A., additional, Lerclercq, C., additional, Daubert, J., additional, Donal, E., additional, Arjan Singh, R., additional, Sivarani, S., additional, Lim, S., additional, Azman, W., additional, Almeida, M., additional, Cardim, N., additional, Fonseca, V., additional, Carmelo, V., additional, Santos, S., additional, Santos, T., additional, Toste, J., additional, Kosmala, W., additional, Orda, A., additional, Karolko, B., additional, Mysiak, A., additional, Przewlocka-Kosmala, M., additional, Farsalinos, K., additional, Tsiapras, D., additional, Kyrzopoulos, S., additional, Avramidou, E., additional, Vassilopoulou, D., additional, Voudris, V., additional, Hayrapetyan, H., additional, Adamyan, K., additional, Montero Cabezas, J., additional, Granda Nistal, C., additional, Garcia Aranda, B., additional, Sanchez Sanchez, V., additional, Sestito, A., additional, Lamendola, P., additional, Di Franco, A., additional, Lauria, C., additional, Lanza, G., additional, Kukucka, M., additional, Unbehaun, A., additional, Buz, S., additional, Mladenow, A., additional, Kuppe, H., additional, Pasic, M., additional, Habazettl, H., additional, Gemma, D., additional, Montoro Lopez, N., additional, De Celix, M. G. R., additional, Lopez Fernandez, T., additional, De Torres Alba, F., additional, Del Valle, D. I., additional, Ramirez, U., additional, Mesa, J., additional, Moreno Yanguela, M., additional, Lopez Sendon, J., additional, Eveborn, G. W., additional, Schirmer, H., additional, Lunde, P., additional, Heggelund, G., additional, Rasmussen, K., additional, Wang, Z., additional, Lasota, B., additional, Mizia-Stec, K., additional, Mizia, M., additional, Chmiel, A., additional, Adamczyk, T., additional, Chudek, J., additional, Gasior, Z., additional, Venkatesh, A., additional, Johnson, J., additional, Sahlen, A., additional, Brodin, L., additional, Winter, R., additional, Shahgaldi, K., additional, Manouras, A., additional, Valbuena, S., additional, Iniesta, A., additional, Lopez, T., additional, De Torres, F., additional, Salinas, P., additional, Garcia, S., additional, Moreno, M., additional, Lopez-Sendon, J., additional, Lebid, I., additional, Kobets, T., additional, Kuzmenko, T., additional, Katsanos, S., additional, Yiu, K., additional, Clavel, M., additional, Nina Ajmone, N., additional, Van Der Kley, F., additional, Rodes Cabau, J., additional, Schalij, M., additional, Bax, J., additional, Pibarot, P., additional, Delgado, V., additional, Fusini, L., additional, Tamborini, G., additional, Muratori, M., additional, Gripari, P., additional, Marsan, N., additional, Cefalu', C., additional, Ewe, S., additional, Maffessanti, F., additional, Pepi, M., additional, Hasselberg, N., additional, Haugaa, K., additional, Petri, H., additional, Berge, K., additional, Leren, T., additional, Bundgaard, H., additional, Edvardsen, T., additional, Ancona, R., additional, Comenale Pinto, S., additional, Caso, P., additional, Coppola, M., additional, Rapisarda, O., additional, Cavallaro, C., additional, Vecchione, F., additional, D'onofrio, A., additional, Calabro', R., additional, Rimbas, R., additional, Mihaila, S., additional, Enescu, O., additional, Patrascu, N., additional, Dragoi, R., additional, Rimbas, M., additional, Pop, C., additional, Vinereanu, D., additional, Gustafsson, S., additional, Morner, S., additional, Gronlund, C., additional, Suhr, O., additional, Lindqvist, P., additional, Di Bella, G., additional, Zito, C., additional, Minutoli, F., additional, Madaffari, A., additional, Cusma Piccione, M., additional, Mazzeo, A., additional, Massimo, R., additional, Pasquale, M., additional, Vita, G., additional, Carerj, S., additional, Rangel, I., additional, Goncalves, A., additional, Sousa, C., additional, Correia, A., additional, Martins, E., additional, Silva-Cardoso, J., additional, Macedo, F., additional, Maciel, M., additional, Pfeiffer, B., additional, Rigopoulos, A., additional, Seggewiss, H., additional, Alvarez Fuente, M., additional, Sainz Costa, T., additional, Medrano, C., additional, Navarro, M., additional, Blazquez Gamero, D., additional, Ramos, J., additional, Mellado, M., additional, De Jose, M., additional, Munoz, M., additional, Maroto, E., additional, Gargani, L., additional, Gosciniak, P., additional, Pratali, L., additional, Agoston, G., additional, Bruni, C., additional, Guiducci, S., additional, Matucci Cerinic, M., additional, Varga, A., additional, Sicari, R., additional, Picano, E., additional, Zhao, C., additional, Mei, M., additional, Yeung, C., additional, Siu, C., additional, Tse, H., additional, Florescu, M., additional, Magda, L., additional, Mincu, R., additional, Daha, I., additional, Stanescu, C. M., additional, Chirila, L., additional, Baicus, C., additional, Vlase, A., additional, Dan, G., additional, Montoro Lopez, M., additional, Florez Gomez, R., additional, Alonso Ladreda, A., additional, Itziar Soto, C., additional, Rios Blanco, J., additional, Guzman Martinez, G., additional, Lichodziejewska, B., additional, Kurnicka, K., additional, Goliszek, S., additional, Kostrubiec, M., additional, Dzikowska-Diduch, O., additional, Ciurzynski, M., additional, Labyk, A., additional, Krupa, M., additional, Palczewski, P., additional, Pruszczyk, P., additional, De Sousa, C. C., additional, Vigario, A., additional, Pinho, T., additional, Silva Cardoso, J., additional, Park, S.-J., additional, Song, J.-E., additional, Lee, Y.-J., additional, Ha, M.-R., additional, Chang, S.-A., additional, Choi, J.-O., additional, Lee, S.-C., additional, Park, S., additional, Oh, J., additional, Van De Bruaene, A., additional, De Meester, P., additional, Buys, R., additional, Vanhees, L., additional, Delcroix, M., additional, Voigt, J., additional, Budts, W., additional, Blundo, A., additional, Buccheri, S., additional, Monte, I. P., additional, Leggio, S., additional, Tamburino, C., additional, Sotaquira, M., additional, Lang, R., additional, Caiani, E., additional, Floria, M., additional, De Roy, L., additional, Xhaet, O., additional, Blommaert, D., additional, Jamart, J., additional, Gerard, M., additional, Deceuninck, O., additional, Marchandise, B., additional, Seldrum, S., additional, Schroeder, E., additional, Unsworth, B., additional, Sohaib, S., additional, Kulwant-Kaur, K., additional, Malcolme-Lawes, L., additional, Kanagaratnam, P., additional, Malik, I., additional, Ren, B., additional, Mulder, H., additional, Haak, A., additional, Van Stralen, M., additional, Szili-Torok, T., additional, Pluim, J., additional, Geleijnse, M., additional, Bosch, J., additional, Baglini, R., additional, Amaducci, A., additional, D'ancona, G., additional, Van Den Oord, S., additional, Akkus, Z., additional, Ten Kate, G., additional, Renaud, G., additional, Sijbrands, E., additional, De Jong, N., additional, Van Der Lugt, A., additional, Van Der Steen, A., additional, Schinkel, A., additional, Bjallmark, A., additional, Larsson, M., additional, Grishenkov, D., additional, Brodin, L.-A., additional, Brismar, T., additional, Paradossi, G., additional, Sveen, K. A., additional, Nerdrum, T., additional, Hanssen, K., additional, Dahl-Jorgensen, K., additional, Steine, K., additional, Cimino, S., additional, Pedrizzetti, G., additional, Tonti, G., additional, Canali, E., additional, Petronilli, V., additional, Cicogna, F., additional, Arcari, L., additional, De Luca, L., additional, Iacoboni, C., additional, Agati, L., additional, Abdel Moneim, S. S., additional, Eifert Rain, S., additional, Bernier, M., additional, Bhat, G., additional, Hagen, M., additional, Bott-Kitslaar, D., additional, Castello, R., additional, Wilansky, S., additional, Pellikka, P., additional, Mulvagh, S., additional, Delithanasis, I., additional, Celutkiene, J., additional, Kenny, C., additional, Monaghan, M., additional, Park, W., additional, Hong, G., additional, Son, J., additional, Lee, S., additional, Kim, U., additional, Park, J., additional, Shin, D., additional, Kim, Y., additional, Toutouzas, K., additional, Drakopoulou, M., additional, Aggeli, C., additional, Felekos, I., additional, Nikolaou, C., additional, Synetos, A., additional, Stathogiannis, K., additional, Tsiamis, E., additional, Siores, E., additional, Stefanadis, C., additional, Plicht, B., additional, Kahlert, P., additional, Grave, T., additional, Buck, T., additional, Konorza, T., additional, Gursoy, M., additional, Gokdeniz, T., additional, Astarcioglu, M., additional, Bayram, Z., additional, Cakal, B., additional, Karakoyun, S., additional, Kalcik, M., additional, Acar, R., additional, Kahveci, G., additional, Ozkan, M., additional, Tsang, W., additional, Weinert, L., additional, Yurdakul, S., additional, Avci, B., additional, Sahin, S., additional, Dilekci, B., additional, Aytekin, S., additional, Arenga, F., additional, Hascoet, S., additional, Martin, R., additional, Dulac, Y., additional, Peyre, M., additional, Benzouid, C., additional, Hadeed, K., additional, Acar, P., additional, Zakarkaite, D., additional, Skorniakov, V., additional, Zvironaite, V., additional, Grabauskiene, V., additional, Burca, J., additional, Ciparyte, L., additional, Laucevicius, A., additional, Di Salvo, G., additional, Rea, A., additional, D'aiello, A., additional, Del Gaizo, F., additional, Pergola, V., additional, D'andrea, A., additional, Pacileo, G., additional, Calabro, R., additional, Russo, M., additional, Dedobbeleer, C., additional, Hadefi, A., additional, Naeije, R., additional, Unger, P., additional, Mornos, C., additional, Cozma, D., additional, Ionac, A., additional, Mornos, A., additional, Valcovici, M., additional, Pescariu, S., additional, Petrescu, L., additional, Hu, K., additional, Liu, D., additional, Niemann, M., additional, Herrmann, S., additional, Cikes, M., additional, Stoerk, S., additional, Knop, S., additional, Ertl, G., additional, Bijnens, B., additional, Weidemann, F., additional, De Knegt, M., additional, Biering-Sorensen, T., additional, Sogaard, P., additional, Sivertsen, J., additional, Jensen, J., additional, Mogelvang, R., additional, Lam, W., additional, Tang, M., additional, Chan, K., additional, Yang, Y., additional, Fang, F., additional, Sun, J., additional, Yu, C., additional, Lam, Y., additional, Panoulas, V., additional, Sulemane, S., additional, Bratsas, A., additional, Konstantinou, K., additional, Francone, M., additional, Schau, T., additional, Seifert, M., additional, Ridjab, D., additional, Schoep, M., additional, Gottwald, M., additional, Neuss, M., additional, Meyhoefer, J., additional, Zaenker, M., additional, Butter, C., additional, Tarr, A., additional, Stoebe, S., additional, Pfeiffer, D., additional, Hagendorff, A., additional, Maret, E., additional, Ahlander, B.-M., additional, Bjorklund, P.-G., additional, Engvall, J., additional, Staskiewicz, G., additional, Czekajska-Chehab, E., additional, Adamczyk, P., additional, Siek, E., additional, Przybylski, P., additional, Maciejewski, R., additional, Drop, A., additional, Jimenez Rubio, C., additional, Isasti Aizpurua, G., additional, Miralles Ibarra, J., additional, Al-Mallah, M., additional, Somg, T., additional, Alam, S., additional, Chattahi, J., additional, Zweig, B., additional, Dhanalakota, K., additional, Boedeker, S., additional, Ananthasubramaniam, K., additional, Park, C., additional, March, K., additional, Jones, S., additional, Mayet, J., additional, Tillin, T., additional, Chaturvedi, N., additional, Hughes, A., additional, Hamodraka, E., additional, Kallistratos, E., additional, Karamanou, A., additional, Tsoukas, T., additional, Mavropoulos, D., additional, Kouremenos, N., additional, Zaharopoulou, I., additional, Nikolaidis, N., additional, Kremastinos, D., additional, Manolis, A., additional, Loboz-Rudnicka, M., additional, Jaroch, J., additional, Bociaga, Z., additional, Kruszynska, E., additional, Ciecierzynska, B., additional, Dziuba, M., additional, Dudek, K., additional, Uchmanowicz, I., additional, Loboz-Grudzien, K., additional, Silva, D., additional, Magalhaes, A., additional, Jorge, C., additional, Cortez-Dias, N., additional, Carrilho-Ferreira, P., additional, Silva Marques, J., additional, Portela, I., additional, Pascoa, C., additional, Nunes Diogo, A., additional, Brito, D., additional, Roosens, B., additional, Bala, G., additional, Droogmans, S., additional, Hostens, J., additional, Somja, J., additional, Delvenne, E., additional, Schiettecatte, J., additional, Lahoutte, T., additional, Van Camp, G., additional, and Cosyns, B., additional

Published
2012
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9. Rapid Acute Coronary Syndrome Evaluation Over One Hour With High-Sensitivity Cardiac Troponin I: A United States-Based Stepped-Wedge, Randomized Trial.

Author

Miller J, Cook B, Gandolfo C, Mills NL, Mahler S, Levy P, Parikh S, Krupp S, Nour K, Klausner H, Gindi R, Lewandowski A, Hudson M, Perrotta G, Zweig B, Lanfear D, Kim H, Dangoulian S, Tang A, Todter E, Khan A, Keerie C, Bole S, Nasseredine H, Oudeif A, Abou Asala E, Mohammed M, Kazem A, Malette K, Singh-Kucukarslan G, Xu N, Wittenberg S, Morton T, Gunaga S, Affas Z, Tabbaa K, Desai P, Alsaadi A, Mahmood S, Schock A, Konowitz N, Fuchs J, Joyce K, Shamoun L, Babel J, Broome A, Digiacinto G, Shaheen E, Darnell G, Muller G, Heath G, Bills G, Vieder J, Rockoff S, Kim B, Colucci A, Plemmons E, and McCord J

Subjects
Humans, Male, Female, Middle Aged, United States, Aged, Time Factors, Troponin I blood, Acute Coronary Syndrome blood, Acute Coronary Syndrome diagnosis, Emergency Service, Hospital, Myocardial Infarction blood, Myocardial Infarction diagnosis, Biomarkers blood
Abstract

Study Objective: The real-world effectiveness and safety of a 0/1-hour accelerated protocol using high-sensitivity cardiac troponin (hs-cTn) to exclude myocardial infarction (MI) compared to routine care in the United States is uncertain. The objective was to compare a 0/1-hour accelerated protocol for evaluation of MI to a 0/3-hour standard care protocol., Methods: The RACE-IT trial was a stepped-wedge, randomized trial across 9 emergency departments (EDs) that enrolled 32,609 patients evaluated for possible MI from July 2020 through April 2021. Patients undergoing high-sensitivity cardiac troponin I testing with concentrations less than or equal to 99th percentile were included. Patients who had MI excluded by the 0/1-hour protocol could be discharged from the ED. Patients in the standard care protocol had 0- and 3-hour troponin testing and application of a modified HEART score to be eligible for discharge. The primary endpoint was the proportion of patients discharged from the ED without 30-day death or MI., Results: There were 13,505 and 19,104 patients evaluated in the standard care and accelerated protocol groups, respectively, of whom 19,152 (58.7%) were discharged directly from the ED. There was no significant difference in safe discharges between standard care and the accelerated protocol (59.5% vs 57.8%; adjusted odds ratio (aOR)=1.05, 95% confidence interval [CI] 0.95 to 1.16). At 30 days, there were 90 deaths or MIs with 38 (0.4%) in the standard care group and 52 (0.4%) in the accelerated protocol group (aOR=0.84, 95% CI 0.43 to 1.68)., Conclusion: A 0/1-hour accelerated protocol using high-sensitivity cardiac troponin I did not lead to more safe ED discharges compared with standard care., (Copyright © 2024 American College of Emergency Physicians. Published by Elsevier Inc. All rights reserved.)

Published
2024
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10. Is rapid acute coronary syndrome evaluation with high-sensitivity cardiac troponin less costly? An economic evaluation.

Author

Danagoulian S, Miller J, Cook B, Gunaga S, Fadel R, Gandolfo C, Mills NL, Modi S, Mahler SA, Levy PD, Parikh S, Krupp S, Abdul-Nour K, Klausner H, Rockoff S, Gindi R, Lewandowski A, Hudson M, Perrotta G, Zweig B, Lanfear D, Kim H, Shaheen E, Darnell G, Nassereddine H, Hawatian K, Tang A, Keerie C, and McCord J

Abstract

Objective: Protocols to evaluate for myocardial infarction (MI) using high-sensitivity cardiac troponin (hs-cTn) have the potential to drive costs upward due to the added sensitivity. We performed an economic evaluation of an accelerated protocol (AP) to evaluate for MI using hs-cTn to identify changes in costs of treatment and length of stay compared with conventional testing., Methods: We performed a planned secondary economic analysis of a large, cluster randomized trial across nine emergency departments (EDs) from July 2020 to April 2021. Patients were included if they were 18 years or older with clinical suspicion for MI. In the AP, patients could be discharged without further testing at 0 h if they had a hs-cTnI < 4 ng/L and at 1 h if the initial value were 4 ng/L and the 1-h value ≤7 ng/L. Patients in the standard of care (SC) protocol used conventional cTn testing at 0 and 3 h. The primary outcome was the total cost of treatment, and the secondary outcome was ED length of stay., Results: Among 32,450 included patients, an AP had no significant differences in cost (+$89, CI: -$714, $893 hospital cost, +$362, CI: -$414, $1138 health system cost) or ED length of stay (+46, CI: -28, 120 min) compared with the SC protocol. In lower acuity, free-standing EDs, patients under the AP experienced shorter length of stay (-37 min, CI: -62, 12 min) and reduced health system cost (-$112, CI: -$250, $25)., Conclusion: Overall, the implementation of AP using hs-cTn does not result in higher costs., Competing Interests: Joe Miller: Research support and consulting for Beckman Coulter; consulting for Siemens and AstraZeneca. Ben Cook: Research support for Abbott; research support and consulting for Beckman Coulter; research support for Roche. David Lanfear: Abbott Laboratories, Amgen, Astra Zeneca, Cytokinetics, DCRI (CONNECT‐HF), Illumina, Janssen, Lilly, Martin Pharmaceuticals, Ortho Diagnostics, Otsuka, Somalogic, Vicardia. Simon Mahler: funding/support from Roche Diagnostics, Abbott Laboratories, Ortho Clinical Diagnostics, Siemens, Grifols, Pathfast, Quidel, and HRSA (1H2ARH399760100). He is an advisor for Roche Diagnostics, Abbott Laboratories, Genetesis, Quidel, Inflammatix, Radiometer, and Amgen and the Chief Medical Officer for Impathiq Inc. Phil Levy: past chair of the American College of Cardiology (ACC) Accreditation Oversight Committee and a current member of the ACC NCDR Oversight Committee and the NCDR Chest Pain/MI Registry Publications Committee; he was also Vice Chair for the ACC/AHA Chest Pain Guidelines. Dr. Levy has served as a consultant for Quidel, Siemens, Roche Diagnostics, Ortho Diagnostics, Beckman Coulter, Pathfast, and the Baim Institute. James McCord: research support for Roche and Abbott; research support and consulting for Siemens and Beckman Coulter. Nicholas Mills has received honoraria or consultancy from Abbott Diagnostics, Roche Diagnostics, Siemens Healthineers, and LumiraDx, and the University of Edinburgh has received research grants from Abbott Diagnostics and Siemens Healthineers is supported by Chair, Programme and Research Excellence Awards (CH/F/21/90010, RG/20/10/34966, RE/18/5/34216) from the British Heart Foundation. Other coauthors have no disclosures to make., (© 2024 The Authors. Journal of the American College of Emergency Physicians Open published by Wiley Periodicals LLC on behalf of American College of Emergency Physicians.)

Published
2024
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11. COVID-19 resulting in bilateral pulmonary emboli and a right ventricular thrombus: association or causation? A case report.

Author

Kaplan JG, Kanwal A, Malek R, Dickey JQ, Keirn R, Zweig B, and Minter D

Abstract

Background: SARS-CoV-2 is a novel viral illness originating out of Wuhan China in late 2019. This global pandemic has infected nearly 3 million people and accounted for 200 000 deaths worldwide, with those numbers still climbing., Case Summary: We present a 54-year-old patient who developed respiratory failure requiring endotracheal intubation from her infection with SARS-CoV-2. This patient was subsequently found to have a right ventricular thrombus and bilateral pulmonary emboli, likely contributing to her respiratory status. On the 14th day of hospitalization, the patient was successfully extubated, and 5 days later was discharged to the rehabilitation unit., Discussion: SARS-CoV-2 presents primarily with pulmonary symptoms; however, many patients, particularly those who are severely ill, exhibit adverse events related to hypercoagulability. The exact mechanism explaining this hypercoagulable state has yet to be elucidated, but these thrombotic events have been linked to the increased inflammation caused by SARS-CoV-2. This novel viral illness is still largely misunderstood, but the hypercoagulable state, seen in severely ill patients, appears to play a major role in disease progression and prognosis., (© The Author(s) 2020. Published by Oxford University Press on behalf of the European Society of Cardiology.)

Published
2020
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12. Cardiac Dysrhythmias and Neurological Dysregulation: Manifestations of Profound Hypomagnesemia.

Author

Mawri S, Gildeh E, Joseph N, Rabbani B, and Zweig B

Abstract

Magnesium is the second most common intracellular cation and serves as an important metabolic cofactor to over 300 enzymatic reactions throughout the human body. Among its various roles, magnesium modulates calcium entry and release from sarcoplasmic reticulum and regulates ATP pumps in myocytes and neurons, thereby regulating cardiac and neuronal excitability. Therefore, deficiency of this essential mineral may result in serious cardiovascular and neurologic derangements. In this case, we present the clinical course of a 76-year-old woman who presented with marked cardiac and neurological signs and symptoms which developed as a result of severe hypomagnesemia. The patient promptly responded to magnesium replacement once the diagnosis was established. We herein discuss the clinical presentation, pathophysiology, diagnosis, and management of severe hypomagnesemia and emphasize the implications of magnesium deficiency in the cardiovascular and central nervous systems. Furthermore, this case highlights the importance of having high vigilance for hypomagnesemia in the appropriate clinical setting.

Published
2017
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13. The effects of laser microtexturing of the dental implant collar on crestal bone levels and peri-implant health.

Author

Botos S, Yousef H, Zweig B, Flinton R, and Weiner S

Subjects
Adult, Aged, Dental Implantation, Endosseous instrumentation, Dental Plaque Index, Denture, Overlay, Female, Follow-Up Studies, Humans, Lasers, Male, Mandible, Middle Aged, Osseointegration, Periodontal Index, Prospective Studies, Surface Properties, Treatment Outcome, Alveolar Bone Loss prevention & control, Dental Abutments adverse effects, Dental Implants adverse effects, Dental Prosthesis Design adverse effects, Dental Prosthesis, Implant-Supported instrumentation
Abstract

Purpose: Polished and machined collars have been advocated for dental implants to reduce plaque accumulation and crestal bone loss. More recent research has suggested that a roughened titanium surface promotes osseointegration and connective tissue attachment. The purpose of this research was to compare crestal bone height adjacent to implants with laser-microtextured and machined collars from two different implant systems., Materials and Methods: Four implants, two with laser-microtextured collars and two with machined collars, were placed in the anterior mandible to serve as overdenture abutments. They were placed in alternating order, and the distal microtextured- and machined-collar implants were loaded with ball abutments. The mesial implants were left unloaded. The distal implants were immediately loaded with prefabricated dentures. Plaque Index, Bleeding Index, and probing depths (PDs) were measured after 6 and 12 months for the loaded implants. Bone loss for both groups (loaded and unloaded) was evaluated via standardized radiographs., Results: Plaque and bleeding values were similar for both implant types. The microtextured-collar implants showed shallower PDs (0.36 ± 0.5 mm and 0.43 ± 0.51 mm) than those with machined collars (1.14 ± 0.77 mm and 1.64 ± 0.93 mm; < .05 for 6 and 12 months, respectively). At 6 and 12 months, respectively, the microtextured implants showed less crestal bone loss for both loaded (0.19 ± 0.15 mm and 0.42 ± 0.34 mm) and unloaded groups (0.15 ± 0.15 mm and 0.29 ± 0.20 mm) than the machined implants for both the loaded (0.72 ± 0.5 mm and 1.13 ± 0.61 mm) and unloaded groups (0.29 ± 0.28 mm and 0.55 ± 0.32 mm)., Conclusion: Application of laser-microtextured grooves to the implant collar resulted in shallower PDs and less peri-implant crestal bone loss than that seen around implants with machined collars.

Published
2011

14. University of Medicine and Dentistry of New Jersey-New Jersey Dental School Oral and Maxillofacial Surgery Residency Training Program.

Author

Aziz SR, Ziccardi VB, and Zweig B

Subjects
Education, Dental methods, Education, Dental organization & administration, History, 20th Century, Humans, New Jersey, Schools, Dental organization & administration, Schools, Medical history, Schools, Medical organization & administration, Universities organization & administration, Education, Dental history, Internship and Residency, Oral Surgical Procedures education, Schools, Dental history, Universities history
Published
2008
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15. The effects of laser microtextured collars upon crestal bone levels of dental implants.

Author

Weiner S, Simon J, Ehrenberg DS, Zweig B, and Ricci JL

Subjects
Animals, Cell Adhesion, Connective Tissue Cells physiology, Dental Implantation, Endosseous, Dogs, Epithelial Attachment physiology, Epithelial Cells physiology, Gingiva physiology, Lasers, Surface Properties, Dental Etching instrumentation, Dental Implants, Dental Prosthesis Design, Osseointegration
Abstract

Purpose: The purpose of this study was to examine the crestal bone, connective tissue, and epithelial cell response to a laser microtextured collar compared with a machined collar, in the dog model., Materials: Six mongrel dogs had mandibular premolars and first molars extracted and after healing replaced with BioLok implants 4 x 8 mm. Each dog had 3 control implants placed on one side of the mandible and 3 experimental, laser microtextured, implants placed contralaterally. After 3 months, 1 dog was killed. Bridges were placed on the implants of 4 of the dogs. The sixth dog served as a negative control for the duration of the experiment. Two of the dogs were killed 3 months after loading, of the dogs were killed 6 months after loading as was the negative (unloaded) control. Histology, electron microscopy, and histomorpho-metric analysis was done on histologic sections obtained from block sections of the mandible containing the implants., Results: Initially the experimental implants showed greater bone attachment along the collar. With time the bone heights along the control and experimental collars were equivalent. However, the controls had more soft tissue downgrowth, greater osteoclastic activity, and increased saucerization compared with sites adjacent to experimental implants. There was closer adaptation of the bone to the laser microtextured collars., Conclusion: Use of tissue-engineered collars with microgrooving seems to promote bone and soft tissue attachment along the collar and facilitate development of a biological width.

Published
2008
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17. Inhibition of erbB receptor family members protects HaCaT keratinocytes from ultraviolet-B-induced apoptosis.

Author

Lewis DA, Zweig B, Hurwitz SA, and Spandau DF

Subjects
Apoptosis drug effects, Cell Line, ErbB Receptors antagonists & inhibitors, Humans, Phthalimides pharmacology, Receptor, ErbB-2 antagonists & inhibitors, Apoptosis physiology, ErbB Receptors physiology, Keratinocytes physiology, Keratinocytes radiation effects, Receptor, ErbB-2 physiology
Abstract

In the human epidermis, the cells most at risk for the development of cancer due to sunlight exposure are the keratinocytes. In animal models, ultraviolet-B is a complete carcinogen, capable of inducing and promoting the development of malignant cells. A key element of ultraviolet-B-induced carcinogenesis is the ability of ultraviolet-B to induce the expression of a number of cellular proteins and activate growth factor receptor tyrosine kinases, including the erbB receptor family. Keratinocytes express the erbB1 (also called EGF-R, HER1), the erbB2 (also known as neu or HER2), and the erbB3 (HER3) subtypes. In general, activation of the erbB receptor family leads to a cellular proliferative response. In certain instances, however, activation of an erbB receptor can induce differentiation, cell cycle arrest, and even apoptosis. The inhibition of tyrosine kinase activity in rodent models and human skin has been shown to inhibit some ultraviolet-B response pathways. We have shown that the inhibition of erbB receptors, by both pharmaceutical and immunologic means, will inhibit ultraviolet-B-induced apoptosis in the HaCaT human keratinocyte cell line. This inhibition was specific for the erbB receptor family and specific for ultraviolet-B-induced apoptosis. These results suggest that, in certain instances, ultraviolet-B-induced apoptotic signaling requires erbB family receptor activity.

Published
2003
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18. Esthetic analysis of the cervicofacial region.

Author

Zweig BE

Subjects
Centric Relation, Cephalometry, Chin anatomy & histology, Face surgery, Forehead anatomy & histology, Head anatomy & histology, Humans, Lip anatomy & histology, Mouth anatomy & histology, Neck surgery, Nose anatomy & histology, Orbit anatomy & histology, Posture, Plastic Surgery Procedures, Zygoma anatomy & histology, Esthetics, Face anatomy & histology, Neck anatomy & histology
Abstract

For many patients the primary motivating factor for orthognathic surgery is improvement of their facial appearance. In order to achieve a satisfactory esthetic result and satisfy the patients' concerns, a systematic, thorough evaluation should be performed. Because the face is a complex anatomic unit, it is best to evaluate each distinct region of the face separately, taking care to relate the various parts to the whole. During this examination it is important that the patient be in natural head position with the lips in repose and the teeth lightly touching in a centric relationship. Direct measurements from the patient are always more accurate than those obtained from photographs or radiographs. The surgeon should keep in mind that the proper relationships between the various regions of the face are more important than specific angles or numbers.

Published
2000

19. Posterior segmental osteotomy with simultaneous endosseous implant placement to facilitate fixed reconstruction.

Author

Itkin AB, Riker K, McKay K, and Zweig BE

Subjects
Denture, Partial, Fixed, Female, Humans, Maxilla surgery, Middle Aged, Dental Implantation, Endosseous, Osteotomy methods
Abstract

The supra-eruption of the edentulous posterior maxilla may decrease interarch space, thus compromising the construction of an adequate fixed or removable prosthetic appliance (Henderson et al., 1985). The following case report illustrates a treatment which provides additional interarch space facilitating the restoration of the patient's dentition with a fixed prosthetic appliance. This arch space deficiency was corrected by performance of a unilateral posterior maxillary osteotomy with superior repositioning of this segment. Simultaneously, a hydroxylapatite-coated titanium endosteal dental implant was placed. Pre-operative considerations, the surgical procedure, and post-operative management of this problem are discussed.

Published
1990

20. Intraoral corroboration of systemic plasma-cell myeloma. Abbreviated case report.

Author

Barr GS, Zweig B, and Itkin AB

Subjects
Female, Humans, Middle Aged, Mandibular Neoplasms pathology, Multiple Myeloma pathology
Abstract

A patient with a previously diagnosed case of multiple myeloma was readmitted for a pathologic fracture of the hip. Intraoral examination revealed a soft-tissue swelling over the right posterior mandibular ridge. Radiographs showed multiple radiolucent areas of the maxilla and mandible. A needle-biopsy technique was used to confirm the diagnosis of intraoral manifestations of plasma-cell myeloma.

Published
1976
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21. Clinical effects of aspirin and acetaminophen on hemostasis after exodontics.

Author

Pawlak DF, Itkin AB, Lapeyrolerie FM, and Zweig B

Subjects
Blood Coagulation drug effects, Blood Coagulation Tests, Blood Platelets drug effects, Double-Blind Method, Humans, Male, Oral Hemorrhage physiopathology, Acetaminophen pharmacology, Aspirin pharmacology, Hemostasis drug effects, Tooth Extraction
Abstract

The effects of aspirin and acetaminophen on postextraction hemostasis were evaluated in a double-blind study in a group of 43 patients; 20 received aspirin and 23 received acetaminophen. No significant difference was found in the observed postsurgical alveolus bleeding times or the patients' reported length of postoperative bleeding. However, Ivy bleeding times taken after the ingestion of 80 grains of medication showed an elevation in 75% of the aspirin users and in 60% of the acetaminophen group; the mean change in bleeding times was 2.75 times greater in the aspirin group.

Published
1978

22. Dentigerous cyst decompression.

Author

Zweig BE and Itkin AB

Subjects
Adolescent, Humans, Male, Mandibular Diseases, Dentigerous Cyst surgery
Published
1975

26. The modified sagittal osteotomy of the mandible: two case reports.

Author

Pawlak DF, Itkin AB, Zweig B, Stadelmann R, and Lapeyrolerie FM

Subjects
Humans, Malocclusion surgery, Prognathism surgery, Retrognathia surgery, Mandible surgery, Osteotomy methods
Abstract

Two case reports of a modified sagittal split osteotomy of the ramus of the mandible are presented which illustrate a technically simplified modality of treating various dentofacial abnormalities. A brief review of the literature is presented and observations are made on the procedures. The need for future documentation of intraoperative and postoperative results on this type of procedure is recommended.

Published
1978
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27. Evaluation and management of allergy to local anesthesia.

Author

Poplawski F and Zweig BE

Subjects
Acupuncture Therapy, Anesthesia, Dental adverse effects, Drug Hypersensitivity chemically induced, Drug Hypersensitivity prevention & control, Histamine H1 Antagonists administration & dosage, Humans, Skin Tests, Anesthetics, Local adverse effects, Drug Hypersensitivity diagnosis
Published
1980

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