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20 results on '"Zwanenburg, Jaco Jm"'

1. Enlarged perivascular spaces in the basal ganglia are associated with arteries not veins.

Author

Oltmer, Jan, Mattern, Hendrik, Beck, Julia, Yakupov, Renat, Greenberg, Steven M, Zwanenburg, Jaco JM, Arts, Tine, Düzel, Emrah, van Veluw, Susanne J, Schreiber, Stefanie, and Perosa, Valentina

Abstract

Enlarged perivascular spaces (EPVS) are common in cerebral small vessel disease (CSVD) and have been identified as a marker of dysfunctional brain clearance. However, it remains unknown if the enlargement occurs predominantly around arteries or veins. We combined in vivo ultra-high-resolution MRI and histopathology to investigate the spatial relationship of veins and arteries with EPVS within the basal ganglia (BG). Furthermore, we assessed the relationship between the EPVS and measures of blood-flow (blood-flow velocity, pulsatility index) in the small arteries of the BG. Twenty-four healthy controls, twelve non-CAA CSVD patients, and five probable CAA patients underwent a 3 tesla [T] and 7T MRI-scan, and EPVS, arteries, and veins within the BG were manually segmented. Furthermore, the scans were co-registered. Six autopsy-cases were also assessed. In the BG, EPVS were significantly closer to and overlapped more frequently with arteries than with veins. Histological analysis showed a higher proportion of BG EPVS surrounding arteries than veins. Finally, the pulsatility index of BG arteries correlated with EPVS volume. Our results are in line with previous works and establish a pathophysiological relationship between arteries and EPVS, contributing to elucidating perivascular clearance routes in the human brain. [ABSTRACT FROM AUTHOR]

Published
2024
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11. Inter-patient variations in flow boundary conditions at middle cerebral artery from 7T PC-MRI and influence on Computational Fluid Dynamics of intracranial aneurysms

Author

Highfield Research Group, Circulatory Health, Regenerative Medicine and Stem Cells, Cancer, Rajabzadeh-Oghaz, Hamidreza, van Ooij, Pim, Veeturi, Sricharan S., Tutino, Vincent M., Zwanenburg, Jaco JM, Meng, Hui, Highfield Research Group, Circulatory Health, Regenerative Medicine and Stem Cells, Cancer, Rajabzadeh-Oghaz, Hamidreza, van Ooij, Pim, Veeturi, Sricharan S., Tutino, Vincent M., Zwanenburg, Jaco JM, and Meng, Hui

Published
2020

12. Microbleeds colocalize with enlarged juxtacortical perivascular spaces in amnestic mild cognitive impairment and early Alzheimer's disease: A 7 Tesla MRI study

Author

Opleiding Neurologie, Beeldverwerking ISI, Brain, Highfield Research Group, Cancer, Circulatory Health, Regenerative Medicine and Stem Cells, ZL Cerebrovasculaire Ziekten Medisch, Divisie Beeld & Oncologie, Divisie Beeld, MS Geriatrie, Cardiovasculaire Epi Team 7a, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, ZL Algemene Neurologie Medisch, Bouvy, Willem H, van Veluw, Susanne J, Kuijf, Hugo J, Zwanenburg, Jaco Jm, Kappelle, Jaap L, Luijten, Peter R, Koek, Huiberdina L, Geerlings, Mirjam I, Biessels, Geert J, Utrecht Vascular Cognitive Impairment (VCI) Study group, Opleiding Neurologie, Beeldverwerking ISI, Brain, Highfield Research Group, Cancer, Circulatory Health, Regenerative Medicine and Stem Cells, ZL Cerebrovasculaire Ziekten Medisch, Divisie Beeld & Oncologie, Divisie Beeld, MS Geriatrie, Cardiovasculaire Epi Team 7a, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, ZL Algemene Neurologie Medisch, Bouvy, Willem H, van Veluw, Susanne J, Kuijf, Hugo J, Zwanenburg, Jaco Jm, Kappelle, Jaap L, Luijten, Peter R, Koek, Huiberdina L, Geerlings, Mirjam I, Biessels, Geert J, and Utrecht Vascular Cognitive Impairment (VCI) Study group

Published
2020

13. Clinical Vascular Imaging in the Brain at 7 T

Author

Onderzoek Beeld, Researchgr. Neuroradiologie, Highfield Research Group, Regenerative Medicine and Stem Cells, Circulatory Health, Cancer, Arts-assistenten Radiologie, Brain, De Cocker, Laurens Jl, Lindenholz, Arjen, Zwanenburg, Jaco Jm, van der Kolk, Anja, Zwartbol, MHT, Luijten, Peter, Hendrikse, Jeroen, Onderzoek Beeld, Researchgr. Neuroradiologie, Highfield Research Group, Regenerative Medicine and Stem Cells, Circulatory Health, Cancer, Arts-assistenten Radiologie, Brain, De Cocker, Laurens Jl, Lindenholz, Arjen, Zwanenburg, Jaco Jm, van der Kolk, Anja, Zwartbol, MHT, Luijten, Peter, and Hendrikse, Jeroen

Published
2018

14. Relations between location and type of intracranial atherosclerosis and parenchymal damage

Author

Onderzoek Beeld, Brain, Circulatory Health, Radiologie, Highfield Research Group, Regenerative Medicine and Stem Cells, Cancer, Opleiding Neurologie, ZL Algemene Neurologie Medisch, Beeldverwerking ISI, MS Radiologie, Dieleman, Nikki, van der Kolk, Anja G, Zwanenburg, Jaco Jm, Brundel, Manon, Harteveld, Anita A, Biessels, Geert J, Visser, Fredy, Luijten, Peter R, Hendrikse, J, Onderzoek Beeld, Brain, Circulatory Health, Radiologie, Highfield Research Group, Regenerative Medicine and Stem Cells, Cancer, Opleiding Neurologie, ZL Algemene Neurologie Medisch, Beeldverwerking ISI, MS Radiologie, Dieleman, Nikki, van der Kolk, Anja G, Zwanenburg, Jaco Jm, Brundel, Manon, Harteveld, Anita A, Biessels, Geert J, Visser, Fredy, Luijten, Peter R, and Hendrikse, J

Published
2016

15. Cerebral amyloid angiopathy severity is linked to dilation of juxtacortical perivascular spaces

Author

Projectafdeling VCI, ZL Algemene Neurologie Medisch, Circulatory Health, Brain, Opleiding Neurologie, Pathologie Pathologen staf, Cancer, Highfield Research Group, Regenerative Medicine and Stem Cells, Pathologie, van Veluw, Susanne J, Biessels, Geert Jan, Bouvy, Willem H, Spliet, Wim Gm, Zwanenburg, Jaco Jm, Luijten, Peter R, Macklin, Eric A, Rozemuller, Annemieke Jm, Gurol, M Edip, Greenberg, Steven M, Viswanathan, Anand, Martinez-Ramirez, Sergi, Projectafdeling VCI, ZL Algemene Neurologie Medisch, Circulatory Health, Brain, Opleiding Neurologie, Pathologie Pathologen staf, Cancer, Highfield Research Group, Regenerative Medicine and Stem Cells, Pathologie, van Veluw, Susanne J, Biessels, Geert Jan, Bouvy, Willem H, Spliet, Wim Gm, Zwanenburg, Jaco Jm, Luijten, Peter R, Macklin, Eric A, Rozemuller, Annemieke Jm, Gurol, M Edip, Greenberg, Steven M, Viswanathan, Anand, and Martinez-Ramirez, Sergi

Published
2016

16. Cerebral amyloid angiopathy severity is linked to dilation of juxtacortical perivascular spaces

Author

van Veluw, Susanne J, primary, Biessels, Geert Jan, additional, Bouvy, Willem H, additional, Spliet, Wim GM, additional, Zwanenburg, Jaco JM, additional, Luijten, Peter R, additional, Macklin, Eric A, additional, Rozemuller, Annemieke JM, additional, Gurol, M Edip, additional, Greenberg, Steven M, additional, Viswanathan, Anand, additional, and Martinez-Ramirez, Sergi, additional

Published
2015
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20. Endogenous assessment of chronic myocardial infarction with T1ρ-mapping in patients.

Author

van Oorschot, Joep W. M., El Aidi, Hamza, Jansen of Lorkeers, Sanne J., Gho, Johannes M. I. H., Froeling, Martijn, Visser, Fredy, Chamuleau, Steven A. J., Doevendans, Pieter A., Luijten, Peter R., Leiner, Tim, and Zwanenburg, Jaco JM

Subjects
MYOCARDIAL infarction diagnosis, MAGNETIC resonance imaging, MYOCARDIUM, SCARS, QUANTITATIVE research, FIBROSIS, CONTRAST media, DESCRIPTIVE statistics, IN vivo studies, THERAPEUTICS
Abstract

Background: Detection of cardiac fibrosis based on endogenous magnetic resonance (MR) characteristics of the myocardium would yield a measurement that can provide quantitative information, is independent of contrast agent concentration, renal function and timing. In ex vivo myocardial infarction (MI) tissue, it has been shown that a significantly higher T1ρ is found in the MI region, and studies in animal models of chronic MI showed the first in vivo evidence for the ability to detect myocardial fibrosis with native T1ρ-mapping. In this study we aimed to translate and validate T1ρ-mapping for endogenous detection of chronic MI in patients. Methods: We first performed a study in a porcine animal model of chronic MI to validate the implementation of T1ρ-mapping on a clinical cardiovascular MR scanner and studied the correlation with histology. Subsequently a clinical protocol was developed, to assess the feasibility of scar tissue detection with native T1ρ-mapping in patients (n = 21) with chronic MI, and correlated with gold standard late gadolinium enhancement (LGE) CMR. Four T1ρ-weighted images were acquired using a spin-lock preparation pulse with varying duration (0, 13, 27, 45 ms) and an amplitude of 750 Hz, and a T1ρ-map was calculated. The resulting T1ρ-maps and LGE images were scored qualitatively for the presence and extent of myocardial scarring using the 17-segment AHA model. Results: In the animal model (n = 9) a significantly higher T1ρ relaxation time was found in the infarct region (61 ± 11 ms), compared to healthy remote myocardium (36 ± 4 ms) . In patients a higher T1ρ relaxation time (79 ± 11 ms) was found in the infarct region than in remote myocardium (54 ± 6 ms). Overlap in the scoring of scar tissue on LGE images and T1ρ-maps was 74%. Conclusion: We have shown the feasibility of native T1ρ-mapping for detection of infarct area in patients with a chronic myocardial infarction. In the near future, improvements on the T1ρ -mapping sequence could provide a higher sensitivity and specificity. This endogenous method could be an alternative for LGE imaging, and provide additional quantitative information on myocardial tissue characteristics. [ABSTRACT FROM AUTHOR]

Published
2014

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