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6. PD-L1hi plasmablasts limit the T cell response during the acute phase of parasite infections

Author

Adriana Gruppi, Ian A. Cockburn, María Cecilia Ramello, Rodriguez Eva, Jimena Tosello Boari, Pablo F. Canete, Carolina L. Montes, Melisa Gorosito Serran, Facundo Fiocca Vernengo, Yeping Cai, Cristian Gabriel Beccaria, Laura Almada, Carola G. Vinuesa, Alegre, Zuniga I E, and Wehrens E

Subjects
education.field_of_study, T cell, medicine.medical_treatment, Population, Germinal center, Immunosuppression, Biology, Lymphocytic choriomeningitis, medicine.disease, Peripheral blood mononuclear cell, Virus, medicine.anatomical_structure, Antigen, Immunology, medicine, education
Abstract

During infections with protozoan parasites or virus, T cell immunosuppression is generated simultaneously with a high B cell activation. Here, we show that in T. cruzi infection, all plasmablasts detected had higher surface expression of PD-L1, than other mononuclear cells. PD-L1hi plasmablasts were induced in vivo in an antigen-specific manner and required help from Bcl-6+CD4+T cells. PD-L1hi expression was not a characteristic of all antibody-secreting cells since plasma cells found during the chronic phase of infection express PD-L1 but at lower levels. PD-L1hi plasmablasts were also present in mice infected with Plasmodium or with lymphocytic choriomeningitis virus, but not in mice with autoimmune disorders or immunized with T cell-dependent antigens. PD-L1hi plasmablasts suppressed T cell response, via PD-L1, in vitro and in vivo. Thus, this study reveals that extrafollicular PD-L1hi plasmablasts, which precede the germinal center (CG) response, are a suppressive population in infections that may influence T cell response.Brief summaryPathogens develop different strategies to settle in the host. We identified a plasmablats population induced by pathogens in acute infections which suppress T cell response.

Published
2020

7. PD-L1hi plasmablasts limit the T cell response during the acute phase of parasite infections

Author

Serrán, Melisa Gorosito, primary, Vernengo, Facundo Fiocca, additional, Almada, Laura, additional, Beccaria, Cristian G, additional, Canete, Pablo F, additional, Alegre, Jonathan Rocco, additional, Boari, Jimena Tosello, additional, Ramello, Maria Cecilia, additional, Wehrens, Ellen, additional, Cai, Yeping, additional, Zuniga I, Elina, additional, Montes, Carolina L, additional, Rodriguez, Eva V Acosta, additional, Cockburn, Ian A., additional, Vinuesa, Carola G, additional, and Gruppi, Adriana, additional

Published
2020
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12. Setting research priorities to improve global newborn health and prevent stillbirths by 2025

Author

Yoshida, S, Martines, J, Lawn, JE, Wall, S, Souza, JP, Rudan, I, Cousens, S, Aaby, P, Adam, I, Adhikari, RK, Ambalavanan, N, Arifeen, SE, Aryal, DR, Asiruddin, S, Baqui, A, Barros, AJ, Benn, CS, Bhandari, V, Bhatnagar, S, Bhattacharya, S, Bhutta, ZA, Black, RE, Blencowe, H, Bose, C, Brown, J, Bührer, C, Carlo, W, Cecatti, JG, Cheung, PY, Clark, R, Colbourn, T, Conde-Agudelo, A, Corbett, E, Czeizel, AE, Das, A, Day, LT, Deal, C, Deorari, A, Dilmen, U, English, M, Engmann, C, Esamai, F, Fall, C, Ferriero, DM, Gisore, P, Hazir, T, Higgins, RD, Homer, CS, Hoque, DE, Irgens, L, Islam, MT, de Graft-Johnson, J, Joshua, MA, Keenan, W, Khatoon, S, Kieler, H, Kramer, MS, Lackritz, EM, Lavender, T, Lawintono, L, Luhanga, R, Marsh, D, McMillan, D, McNamara, PJ, Mol, BW, Molyneux, E, Mukasa, GK, Mutabazi, M, Nacul, LC, Nakakeeto, M, Narayanan, I, Olusanya, B, Osrin, D, Paul, V, Poets, C, Reddy, UM, Santosham, M, Sayed, R, Schlabritz-Loutsevitch, NE, Singhal, N, Smith, MA, Smith, PG, Soofi, S, Spong, CY, Sultana, S, Tshefu, A, van Bel, F, Gray, LV, Waiswa, P, Wang, W, Williams, SL, Wright, L, Zaidi, A, Zhang, Y, Zhong, N, Zuniga, I, and Bahl, R

Abstract

In 2013, an estimated 2.8 million newborns died and 2.7 million were stillborn. A much greater number suffer from long term impairment associated with preterm birth, intrauterine growth restriction, congenital anomalies, and perinatal or infectious causes. With the approaching deadline for the achievement of the Millennium Development Goals (MDGs) in 2015, there was a need to set the new research priorities on newborns and stillbirth with a focus not only on survival but also on health, growth and development. We therefore carried out a systematic exercise to set newborn health research priorities for 2013-2025.We used adapted Child Health and Nutrition Research Initiative (CHNRI) methods for this prioritization exercise. We identified and approached the 200 most productive researchers and 400 program experts, and 132 of them submitted research questions online. These were collated into a set of 205 research questions, sent for scoring to the 600 identified experts, and were assessed and scored by 91 experts.Nine out of top ten identified priorities were in the domain of research on improving delivery of known interventions, with simplified neonatal resuscitation program and clinical algorithms and improved skills of community health workers leading the list. The top 10 priorities in the domain of development were led by ideas on improved Kangaroo Mother Care at community level, how to improve the accuracy of diagnosis by community health workers, and perinatal audits. The 10 leading priorities for discovery research focused on stable surfactant with novel modes of administration for preterm babies, ability to diagnose fetal distress and novel tocolytic agents to delay or stop preterm labour.These findings will assist both donors and researchers in supporting and conducting research to close the knowledge gaps for reducing neonatal mortality, morbidity and long term impairment. WHO, SNL and other partners will work to generate interest among key national stakeholders, governments, NGOs, and research institutes in these priorities, while encouraging research funders to support them. We will track research funding, relevant requests for proposals and trial registers to monitor if the priorities identified by this exercise are being addressed.

Published
2016

13. Setting research priorities to improve global newborn health and prevent stillbirths by 2025

Author

Yoshida, S., Martines, J., Lawn, J. E., Wall, S., Souza, J. P., Rudan, I., Cousens, S., Aaby, P., Adam, I., Adhikari, R. K., Ambalavanan, N., Arifeen, S. E. I., Aryal, D. R., Asiruddin, S. K., Baqui, A., Barros, A. J. D., Benn, C. S., Bhandari, V., Bhatnagar, S., Bhattacharya, S., Bhutta, Z. A., Black, R. E., Blencowe, H., Bose, C., Brown, J., Bührer, C., Carlo, W., Cecatti, J. G., Cheung, P., Clark, R., Colbourn, T., Conde-Agudelo, A., Corbett, E., Czeizel, A. E., Abhik Das, Day, L. T., Deal, C., Deorari, A., Dilmen, U., English, M., Engmann, C., Esamai, F., Fall, C., Ferriero, D. M., Gisore, P., Hazir, T., Higgins, R. D., Homer, C. S. E., Hoque, D. E., Irgens, L., Islam, M. T., Graft-Johnson, J., Joshua, M. A., Keenan, W., Khatoon, S., Kieler, H., Kramer, M. S., Lackritz, E. M., Lavender, T., Lawintono, L., Luhanga, R., Marsh, D., Mcmillan, D., Mcnamara, P. J., Mol, B. J., Molyneux, E., Mukasa, G. K., Mutabazi, M., Nacul, L. C., Nakakeeto, M., Narayanan, I., Olusanya, B., Osrin, D., Paul, V., Poets, C., Reddy, U. M., Santosham, M., Sayed, R., Schlabritz-Loutsevitch, N. E., Singhal, N., Smith, M. A., Smith, P. G., Soofi, S., Spong, C. Y., Sultana, S., Tshefu, A., Bel, F., Gray, L. V., Waiswa, P., Wang, W., Williams, S. L. A., Wright, L., Zaidi, A., Zhang, Y., Zhong, N., Zuniga, I., Bahl, R., and APH - Amsterdam Public Health

Subjects
priorities, newborn, Research, lcsh:Public aspects of medicine, lcsh:R, Research Theme: Global Health Research Priorities, lcsh:Medicine, health, lcsh:RA1-1270, improve
Abstract

Background In 2013, an estimated 2.8 million newborns died and 2.7 million were stillborn. A much greater number suffer from long term impairment associated with preterm birth, intrauterine growth restriction, congenital anomalies, and perinatal or infectious causes. With the approaching deadline for the achievement of the Millennium Development Goals (MDGs) in 2015, there was a need to set the new research priorities on newborns and stillbirth with a focus not only on survival but also on health, growth and development. We therefore carried out a systematic exercise to set newborn health research priorities for 2013–2025. Methods We used adapted Child Health and Nutrition Research Initiative (CHNRI) methods for this prioritization exercise. We identified and approached the 200 most productive researchers and 400 program experts, and 132 of them submitted research questions online. These were collated into a set of 205 research questions, sent for scoring to the 600 identified experts, and were assessed and scored by 91 experts. Results Nine out of top ten identified priorities were in the domain of research on improving delivery of known interventions, with simplified neonatal resuscitation program and clinical algorithms and improved skills of community health workers leading the list. The top 10 priorities in the domain of development were led by ideas on improved Kangaroo Mother Care at community level, how to improve the accuracy of diagnosis by community health workers, and perinatal audits. The 10 leading priorities for discovery research focused on stable surfactant with novel modes of administration for preterm babies, ability to diagnose fetal distress and novel tocolytic agents to delay or stop preterm labour. Conclusion These findings will assist both donors and researchers in supporting and conducting research to close the knowledge gaps for reducing neonatal mortality, morbidity and long term impairment. WHO, SNL and other partners will work to generate interest among key national stakeholders, governments, NGOs, and research institutes in these priorities, while encouraging research funders to support them. We will track research funding, relevant requests for proposals and trial registers to monitor if the priorities identified by this exercise are being addressed.

Published
2016

14. Electrical characterization of a‐C:H as a dielectric material in metal/insulator/metal structures

Author

W. Calleja-A, A. Torres-J, Andrey Kosarev, F.J. De la Hidalga-W, C. Zuniga-I, P. Rosales-Q, and Oleksandr Malik

Subjects
Carbon film, Materials science, Electrical resistivity and conductivity, Annealing (metallurgy), Analytical chemistry, Schottky diode, Biasing, Dielectric, Metal-insulator-metal, Condensed Matter Physics, Ohmic contact
Abstract

The fabrication and electrical characterization of Metal-Insulator-Metal (MIM) structures, using a-C:H films as the insulating material, are presented in this work. These PECVD carbon films show a very low dielectric constant and a very high resistivity. The current conduction mechanisms were analyzed before and after the post deposition annealing in pure argon ambient at 400°C. For as-deposited films, the experimental J -U curves showed that under low biasing regime (|U | 8 V)) the current transport is dominated by the Schottky mechanism. For annealed structures, under low and high biasing the ohmic and Schottky mechanisms were identified as the main processes for the electrical transport. Finally, we found that both parameters, the dielectric constant and resistivity, decrease slightly after the thermal annealing. (© 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim)

Published
2010

15. Quantum (5 5 12)Si Nanowire 300K MOSFET

Author

Michael Kendall, Miguel Castro-L, Francisco J. De la Hidalga-W, W. Calleja-A, A. Torres-J, Roberto Murphy-A, Don L. Kendall, Ramiro Rodríguez-M, Ignacio Juárez-R, C. Zuniga-I, Elizabeth Meza Prieto, Netzahualcoyotl Carlos-R, and Mauro Landa-V

Subjects
Materials science, business.industry, MOSFET, Nanowire, Optoelectronics, business, Quantum
Abstract

A nanowire (NW) device in parallel with a normal nMOSFET is fabricated with a poly-Si planar CMOS process on (5 5 12)Si. With a unit cell of 5.35 nm, this plane has the largest stable atomically flat Si surface. When output current Isd flows from source S to drain D along , the device has 15 positive spikes at integer multiples of 154 mV, all at 300K and zero magnetic field. Ids has only 9 positive and 2 negative spikes. The positive spikes in Isd and Ids are due to parabolic confinement of elongated q-dots in the NWs near D. Both Isd and Ids show missing spikes and one-dimensional artificial atom behavior. The negative spikes appear to be Kronig-Penney effects on the NWs. The NWs and q-dots have estimated widths near 2 nm and Line Edge Roughness (LER) less than 0.1 nm due to the crystal-lattice precision of the surface.

Published
2008

16. Efficient ITO–Si solar cells and power modules fabricated with a low temperature technology: Results and perspectives

Author

C. Zuniga-I, F.J. De la Hidalga-W, G. Ruiz-T, and Oleksandr Malik

Subjects
Materials science, Silicon, business.industry, Doping, Oxide, chemistry.chemical_element, Mineralogy, Condensed Matter Physics, Tin oxide, Electronic, Optical and Magnetic Materials, chemistry.chemical_compound, chemistry, Photovoltaics, Power module, Materials Chemistry, Ceramics and Composites, Optoelectronics, business, Indium, Diode
Abstract

ITO–SiOx–nSi semiconductor–insulator–semiconductor (SIS) structures have been produced with a simple spraying technique. It is shown that the structures obtained in such a way may be considered as an induced p–n diode, in which the polycrystalline tin–doped indium oxide (ITO) layer spray deposited on the preliminary treated silicon surface leads to an inversion p-layer at the interface. Solar cells with an active area of 1–4 cm2 have been fabricated based on ITO–SiOx–nSi structures and studied. Under AM0 illumination conditions, the efficiency is nearly 11%, whereas it exceeds 12% for AM1.5 illumination conditions. The theoretical analysis provided in this work shows a good agreement with experimental results and allows for predicting the efficiency of the cells depending on the silicon electro-physical properties.

Published
2008

17. Digital output silicon optical sensors

Author

F. Javier De la Hidalga-W, Oleksandr Malik, and C. Zuniga-I

Subjects
Signal processing, Materials science, business.industry, Metals and Alloys, Electrical engineering, Condensed Matter Physics, Signal, Surfaces, Coatings and Films, Electronic, Optical and Magnetic Materials, law.invention, Capacitor, Intelligent sensor, law, Optical transistor, Hardware_INTEGRATEDCIRCUITS, Electronic engineering, Digital signal, Electrical and Electronic Engineering, business, Instrumentation, Diode, Voltage
Abstract

For the first time, a detailed description of low cost new intelligent (or smart) two-terminal optoelectronic devices without any on-chip circuitry for signal processing is presented. The design of the devices is based on the intelligent integration of micro-sized diodes and metal-oxide-semiconductor (MOS) capacitors. By combining physical processes and a functional voltage bias, such optical sensors transform the received analog input non-modulated optical signal directly into a pulse-width modulated electrical signal; the duty of the signal depends on the irradiation level, and the whole process is conducted without any integrated or external analog-to-digital converter. When the optical sensors operate under a pulsed irradiation synchronized with the functional voltage bias, unconventional logic properties are obtained that can be used to identify the emission from two equal LEDs.

Published
2008

18. Pulse characteristics of silicon double barrier optical sensors with signal amplification

Author

F. Javier De la Hidalga-W, C. Zuniga-I, and Oleksandr Malik

Subjects
Silicon, business.industry, Schottky barrier, Metals and Alloys, chemistry.chemical_element, Condensed Matter Physics, Surfaces, Coatings and Films, Electronic, Optical and Magnetic Materials, Pulse characteristics, chemistry, Electric field, Rectangular potential barrier, Optoelectronics, Wafer, Electrical and Electronic Engineering, business, Instrumentation, Signal amplification, Voltage
Abstract

The pulse characteristics of optical sensors with double potential barriers formed on the opposite sides of a high-resistivity (ν) silicon substrate have been studied. The first barrier is formed by multiple micro-sized Ti–νSi contact barriers surrounded by Ti–SiO 2 –νSi MOS structures. The second one is the ν–n + potential barrier formed at the bottom of the wafer. The structure presents signal amplification for both polarities of the applied voltage. Under negative bias applied to the semi-transparent Ti-electrode, the reason of the current gain is the change in the transport mechanism of carriers through the potential barrier of the Schottky barrier along its perimeter, which is due to the strong electric field originated by the photogenerated minority carriers forming an inversion layer at the silicon-oxide interface. Under positive bias, the current gain is due to the operation of the ν–n + potential barrier, which was studied earlier, and in this work it is used for comparison purposes.

Published
2008

20. How do low-birthweight neonates fare 2 years after discharge from a low-technology neonatal care unit in a rural district hospital in Burundi?

Author

van den Boogaard, W., primary, Zuniga, I., additional, Manzi, M., additional, Van den Bergh, R., additional, Lefevre, A., additional, Nanan-N'zeth, K., additional, Duchenne, B., additional, Etienne, W., additional, Juma, N., additional, Ndelema, B., additional, Zachariah, R., additional, and Reid, A., additional

Published
2017
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21. Electrical Characterization of a-C:H as Insulator Material in MIM Structures

Author

P. Rosales, Andrey Kosarev, C. Reyes-Betanzo, W. Calleja-A, A. Torres-J, and C. Zuniga-I

Subjects
Materials science, business.industry, Optoelectronics, Insulator (electricity), business
Abstract

a-C:H with low dielectric constant is a very interesting material for applications as inter-metal insulator material in modern ICs, due to the compatibility of deposition process with silicon technology. In this work the fabrication and electrical characterization of Metal- Insulator-Metal structures using a-C:H as the insulating material is presented. The carrier transport mechanisms in high and low electric field regimes are presented. Structures with Ti electrodes show a transport mechanism controlled by the space charge limited current in the low electric field regime, and a Schottky mechanism in the high electric field regime. Preliminary studies in structures with Al electrodes exhibit a different behavior, the transport mechanism does not look like neither Shocktty nor SCL micahnisms. We propose that a-C:H film is an excellent material for inter-metal insulation applications.

Published
2007

22. Bulk/surface micromachined polymems test chip for the characterization of electrical, mechanical and thermal properties

Author

F. J. De la Hidalga-W, P. Rosales-Q, W. Calleja-A, C. Reyes-B, M. Moreno-M., F. J. Quinones-N, Oleksandr Malik, D. Diaz-A, C. Zuniga-I, and J. Molina-R.

Subjects
Fabrication, Materials science, Polysilicon depletion effect, engineering.material, chemistry.chemical_compound, Surface micromachining, Polycrystalline silicon, Thermal conductivity, Silicon nitride, chemistry, engineering, Electronic engineering, Composite material, Silicon oxide, Phosphosilicate glass
Abstract

In this work we present the design and fabrication of a test chip to be used for the characterization of the main electrical, mechanical and thermal properties of the structural materials involved in the development of polysilicon-based electrothermal actuators. With this combined bulk/surface micromachined chip, parameters such as Young's modulus (E), stretching or compression stresses (±σ), stress gradients (± Δe), electrical resistivity (ρe), doping level (n+), thermal conductivity (K), and thermal capacitance (C) can be obtained. This test chip was fabricated using the PolyMEMS-INAOE fabrication process, in which the main materials involved are silicon oxide, silicon nitride, phosphosilicate glass, aluminum, mono- and polycrystalline silicon. In this combined micromachining technology, the polysilicon film is the main structural material and it is used to build the mechanical actuators.

Published
2014

23. Experimental and theoretical analysis of the conversion efficiency of ITO- nSi solar cells fabricated by a low-cost spray deposition technique

Author

C. Zuniga-I, G. Ruiz-T, Oleksandr Malik, A. Torres-J, and F.J. De la Hidalga-W

Subjects
Fabrication, Materials science, Silicon, business.industry, Energy conversion efficiency, chemistry.chemical_element, Schottky diode, Heterojunction, Quantum dot solar cell, Indium tin oxide, chemistry, Electrical resistivity and conductivity, Optoelectronics, business
Abstract

Inversion p-n ITO-nSi heterojunctions are the most promising low-cost solar cells using mono-crystalline silicon in comparison with ITO-nSi solar cells operating as Schottky diodes. It is shown that ITO-nSi inversion solar cells fabricated on 10 Ω-cm silicon substrates present a conversion efficiency of 10.8 and 12.1% under AM0 and AM1.5 illumination conditions, respectively. Using actual experimental parameters, our theoretical analysis predicts an improved conversion efficiency up to 15% that can be achieved practically using low resistivity silicon substrates.

Published
2008

29. REPRODUCTIVE ENDOCRINOLOGY

Author

Karasu, Y., primary, Dilbaz, B., additional, Demir, B., additional, Dilbaz, S., additional, Secilmis Kerimoglu, O., additional, Ercan, C. M., additional, Keskin, U., additional, Korkmaz, C., additional, Duru, N. K., additional, Ergun, A., additional, de Zuniga, I., additional, Horton, M., additional, Oubina, A., additional, Scotti, L., additional, Abramovich, D., additional, Pascuali, N., additional, Tesone, M., additional, Parborell, F., additional, Bouzas, N., additional, Yang, X. H., additional, Chen, S. L., additional, Chen, X., additional, Ye, D. S., additional, Zheng, H. Y., additional, Nyboe Andersen, A., additional, Lauritsen, M. P., additional, Thuesen, L. L., additional, Khodadadi, M., additional, Shivabasavaiah, S., additional, Mozafari, R., additional, Ansari, Z., additional, Hamdine, O., additional, Broekmans, F., additional, Eijkemans, M. J. C., additional, Cohlen, B. J., additional, Verhoeff, A., additional, van Dop, P. A., additional, Bernardus, R. E., additional, Lambalk, C. B., additional, Oosterhuis, G. J. E., additional, Holleboom, C., additional, van den Dool-Maasland, G. C., additional, Verburg, H. J., additional, van der Heijden, P. F. M., additional, Blankhart, A., additional, Fauser, B. C. J. M., additional, Laven, J. S. E., additional, Macklon, N. S., additional, Agudo, D., additional, Lopez, C., additional, Alonso, M., additional, Huguet, E., additional, Bronet, F., additional, Garcia-Velasco, J. A., additional, Requena, A., additional, Gonzalez Comadran, M., additional, Checa, M. A., additional, Duran, M., additional, Fabregues, F., additional, Carreras, R., additional, Ersahin, A., additional, Kahraman, S., additional, Kavrut, M., additional, Gorgen, B., additional, Acet, M., additional, Dokuzeylul, N., additional, Aybar, F., additional, Lim, S. Y., additional, Park, J. C., additional, Bae, J. G., additional, Kim, J. I., additional, Rhee, J. H., additional, Mahran, A., additional, Abdelmeged, A., additional, El-Adawy, A., additional, Eissa, M., additional, Darne, J., additional, Shaw, R. W., additional, Amer, S. A., additional, Dai, A., additional, Yan, G., additional, He, Q., additional, Hu, Y., additional, Sun, H., additional, Ferrero, H., additional, Gomez, R., additional, Garcia-Pascual, C. M., additional, Simon, C., additional, Gaytan, F., additional, Pellicer, A., additional, Garcia Pascual, C. M., additional, Zimmermann, R. C., additional, Madani, T., additional, Mohammadi Yeganeh, L., additional, Khodabakhshi, S. H., additional, Akhoond, M. R., additional, Hasani, F., additional, Monzo, C., additional, Haouzi, D., additional, Assou, S., additional, Dechaud, H., additional, Hamamah, S., additional, Amer, S., additional, Mahran, M., additional, Shaw, R., additional, Lan, V., additional, Nhu, G., additional, Tuong, H., additional, Mahmoud Youssef, M. A., additional, Aboulfoutouh, I., additional, Al-inany, H., additional, Van Der Veen, F., additional, Van Wely, M., additional, Zhang, Q., additional, Fang, T., additional, Wu, S., additional, Zhang, L., additional, Wang, B., additional, Li, X., additional, Ding, L., additional, Day, A., additional, Fulford, B., additional, Boivin, J., additional, Alanbay, I., additional, Sakinci, M., additional, Coksuer, H., additional, Ozturk, M., additional, Tapan, S., additional, Chung, C. K., additional, Chung, Y., additional, Seo, S., additional, Aksoy, S., additional, Yakin, K., additional, Caliskan, S., additional, Salar, Z., additional, Ata, B., additional, Urman, B., additional, Devroey, P., additional, Arce, J. C., additional, Harrison, K., additional, Irving, J., additional, Osborn, J., additional, Harrison, M., additional, Fusi, F., additional, Arnoldi, M., additional, Cappato, M., additional, Galbignani, E., additional, Galimberti, A., additional, Zanga, L., additional, Frigerio, L., additional, Taghavi, S. A., additional, Ashrafi, M., additional, Karimian, L., additional, Mehdizadeh, M., additional, Joghataie, M., additional, Aflatoonian, R., additional, Xu, B., additional, Cui, Y. G., additional, Gao, L. L., additional, Diao, F. Y., additional, Li, M., additional, Liu, X. Q., additional, Liu, J. Y., additional, Jiang, F., additional, Jee, B. C., additional, Yi, G., additional, Kim, J. Y., additional, Suh, C. S., additional, Kim, S. H., additional, Liu, S., additional, Cai, L. B., additional, Liu, J. J., additional, Ma, X., additional, Geenen, E., additional, Bots, R. S. G. M., additional, Smeenk, J. M. J., additional, Chang, E., additional, Lee, W., additional, Seok, H., additional, Kim, Y., additional, Han, J., additional, Yoon, T., additional, Lazaros, L., additional, Xita, N., additional, Zikopoulos, K., additional, Makrydimas, G., additional, Kaponis, A., additional, Sofikitis, N., additional, Stefos, T., additional, Hatzi, E., additional, Georgiou, I., additional, Atilgan, R., additional, Kumbak, B., additional, Sahin, L., additional, Ozkan, Z. S., additional, Simsek, M., additional, Sapmaz, E., additional, Karacan, M., additional, Alwaeely, F. A., additional, Cebi, Z., additional, Berberoglugil, M., additional, Ulug, M., additional, Camlibel, T., additional, Yelke, H., additional, Kamalak, Z., additional, Carlioglu, A., additional, Akdeniz, D., additional, Uysal, S., additional, Inegol Gumus, I., additional, Ozturk Turhan, N., additional, Regan, S., additional, Yovich, J., additional, Stanger, J., additional, Almahbobi, G., additional, Kara, M., additional, Aydin, T., additional, Turktekin, N., additional, Youssef, M., additional, Al-Inany, H., additional, van der Veen, F., additional, van Wely, M., additional, Hart, R., additional, Doherty, D., additional, Frederiksen, H., additional, Keelan, J., additional, Pennell, C., additional, Newnham, J., additional, Skakkebaek, N., additional, Main, K., additional, Salem, H. T., additional, Ismail, A. a., additional, Viola, M., additional, Siebert, T. I., additional, Steyn, D. W., additional, Kruger, T. F., additional, Robin, G., additional, Dewailly, D., additional, Thomas, P., additional, Leroy, M., additional, Lefebvre, C., additional, soudan, B., additional, Pigny, P., additional, Decanter, C., additional, ElPrince, M., additional, Wang, F., additional, Zhu, Y., additional, Huang, H., additional, Valdez Morales, F., additional, Vital Reyes, V., additional, Mendoza Rodriguez, A., additional, Gamboa Dominguez, A., additional, Cerbon, M., additional, Aizpurua, J., additional, Ramos, B., additional, Luehr, B., additional, Moragues, I., additional, Rogel, S., additional, Cil, A. P., additional, Guler, Z. B., additional, Kisa, U., additional, Albu, A., additional, Radian, S., additional, Grigorescu, F., additional, Albu, D., additional, Fica, S., additional, Al Boghdady, L., additional, Ghanem, M. E., additional, Hassan, M., additional, Helal, A. S., additional, Ozdogan, S., additional, Ozdegirmenci, O., additional, Cinar, O., additional, Goktolga, U., additional, Seeber, B., additional, Tsybulyak, I., additional, Bottcher, B., additional, Grubinger, T., additional, Czech, T., additional, Wildt, L., additional, Wojcik, J., additional, Howles, C. M., additional, Destenaves, B., additional, Arriagada, P., additional, Tavmergen, E., additional, Sahin, G., additional, Akdogan, A., additional, Levi, R., additional, Goker, E. N. T., additional, Loft, A., additional, Smitz, J., additional, Ricciardi, L., additional, Di Florio, C., additional, Busacca, M., additional, Gagliano, D., additional, Immediata, V., additional, Selvaggi, L., additional, Romualdi, D., additional, Guido, M., additional, Bouhanna, P., additional, Salama, S., additional, Kamoud, Z., additional, Torre, A., additional, Paillusson, B., additional, Fuchs, F., additional, Bailly, M., additional, Wainer, R., additional, Tagliaferri, V., additional, Tartaglia, C., additional, Cirella, E., additional, Aflatoonian, A., additional, Eftekhar, M., additional, Mohammadian, F., additional, Yousefnejad, F., additional, De Cicco, S., additional, Campagna, G., additional, Depalo, R., additional, Lippolis, C., additional, Vacca, M., additional, Nardelli, C., additional, Cavallini, A., additional, Panic, T., additional, Mitulovic, G., additional, Franz, M., additional, Sator, K., additional, Tschugguel, W., additional, Pietrowski, D., additional, Hildebrandt, T., additional, Cupisti, S., additional, Giltay, E. J., additional, Gooren, L. J., additional, Oppelt, P. G., additional, Hackl, J., additional, Reissmann, C., additional, Schulze, C., additional, Heusinger, K., additional, Attig, M., additional, Hoffmann, I., additional, Beckmann, M. W., additional, Dittrich, R., additional, Mueller, A., additional, Sharma, S., additional, Singh, S., additional, Chakravarty, A., additional, Sarkar, A., additional, Rajani, S., additional, Chakravarty, B. N., additional, Ozturk, E., additional, Isikoglu, S., additional, Kul, S., additional, Hillensjo, T., additional, Witjes, H., additional, Elbers, J., additional, Mannaerts, B., additional, Gordon, K., additional, Krasnopolskaya, K., additional, Galaktionova, A., additional, Gorskaya, O., additional, Kabanova, D., additional, Venturella, R., additional, Morelli, M., additional, Mocciaro, R., additional, Capasso, S., additional, Cappiello, F., additional, Zullo, F., additional, Monterde, M., additional, Marzal, A., additional, Vega, O., additional, Rubio-Rubio, J. M., additional, Diaz-Garcia, C., additional, Kolibianakis, E., additional, Griesinger, G., additional, Yding Andersen, C., additional, Ocal, P., additional, Guralp, O., additional, Aydogan, B., additional, Irez, T., additional, Cetin, M., additional, Senol, H., additional, Erol, N., additional, Rombauts, L., additional, Van Kuijk, J., additional, Montagut, J., additional, Nogueira, D., additional, Porcu, G., additional, Chomier, M., additional, Giorgetti, C., additional, Nicollet, B., additional, Degoy, J., additional, Lehert, P., additional, Alviggi, C., additional, De Rosa, P., additional, Vallone, R., additional, Picarelli, S., additional, Coppola, M., additional, Conforti, A., additional, Strina, I., additional, Di Carlo, C., additional, De Placido, G., additional, Haeberle, L., additional, Demirtas, O., additional, Fatemi, H., additional, Shapiro, B. S., additional, Mannaerts, B. M., additional, Chimote, M. N., additional, Mehta, B. N., additional, Chimote, N. N., additional, Nath, N. M., additional, Chimote, N. M., additional, Karia, S., additional, Bonifacio, M., additional, Bowman, M., additional, McArthur, S., additional, Jung, J., additional, Cho, S., additional, Choi, Y., additional, Lee, B., additional, Lee, K. H., additional, Kim, C. H., additional, Kwon, S. K., additional, Kang, B. M., additional, Jung, K. S., additional, Basios, G., additional, Trakakis, E., additional, Hatziagelaki, E., additional, Vaggopoulos, V., additional, Tsiavou, A., additional, Panagopoulos, P., additional, Chrelias, C., additional, Kassanos, D., additional, Sarhan, A., additional, Elsamanoudy, A., additional, Harira, M., additional, Dogan, S., additional, Bozdag, G., additional, Esinler, I., additional, Polat, M., additional, and Yarali, H., additional

Published
2012
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31. Posters * Reproductive Endocrinology (i.e. PCOS, Menarche, Menopause etc.)

Author

Fujii, R., primary, Fujita, S., additional, Waseda, T., additional, Oka, Y., additional, Takagi, H., additional, Tomizawa, H., additional, Sasagawa, T., additional, Makinoda, S., additional, Cavagna, M., additional, Braga, D. P. A. F., additional, Figueira, R. C. S., additional, Aoki, T., additional, Maldonado, L. G. L., additional, Iaconelli, A., additional, Borges, E., additional, Prabhakar, s., additional, Dittrich, R., additional, Beckmann, M. W., additional, Hoffmann, I., additional, Mueller, A., additional, Kjotrod, S., additional, Carlsen, S. M., additional, Rasmussen, P. E., additional, Holst-Larsen, T., additional, Mellembakken, J., additional, Thurin-Kjellberg, A., additional, Haapaniemi Kouru, K., additional, Morin Papunen, L., additional, Humaidan, P., additional, Sunde, A., additional, von During, V., additional, Pappalardo, S., additional, Valeri, C., additional, Crescenzi, F., additional, Manna, C., additional, Sallam, H. N., additional, Polec, A., additional, Raki, M., additional, Tanbo, T., additional, Abyholm, T., additional, Fedorcsak, P., additional, Tabanelli, C., additional, Ferraretti, A. P., additional, Feliciani, E., additional, Magli, M. C., additional, Fasolino, C., additional, Gianaroli, L., additional, Wang, T., additional, Feng, C., additional, Song, Y., additional, Dong, M. Y., additional, Sheng, J. Z., additional, Huang, H. F., additional, Sayyah Melli, M., additional, Kazemi-shishvan, M., additional, Snajderova, M., additional, Zemkova, D., additional, Pechova, M., additional, Teslik, L., additional, Lanska, V., additional, Ketel, I., additional, Serne, E., additional, Stehouwer, C., additional, Korsen, T., additional, Hompes, P., additional, Smulders, Y., additional, Voorstemans, L., additional, Homburg, R., additional, Lambalk, C., additional, Bellver, J., additional, Martinez-Conejero, J. A., additional, Pellicer, A., additional, Labarta, E., additional, Alama, P., additional, Melo, M. A. B., additional, Horcajadas, J. A., additional, Agirregoitia, N., additional, Peralta, L., additional, Mendoza, R., additional, Exposito, A., additional, Matorras, R., additional, Agirregoitia, E., additional, Ajina, M., additional, Chaouache, N., additional, Gaddas, M., additional, Souissi, A., additional, Tabka, Z., additional, Saad, A., additional, Zaouali-Ajina, M., additional, Zbidi, A., additional, Eguchi, N., additional, Jinno, M., additional, Watanabe, A., additional, Hirohama, J., additional, Hatakeyama, N., additional, Choi, Y. M., additional, Kim, J. J., additional, Kim, D. H., additional, Yoon, S. H., additional, Ku, S. Y., additional, Kim, S. H., additional, Kim, J. G., additional, Lee, K. S., additional, Moon, S. Y., additional, Xiong, Y., additional, Liang, X., additional, Li, Y., additional, Yang, X., additional, Wei, L., additional, Fujii, R., additional, Utsunomiya, T., additional, Chu, S., additional, Li, P., additional, Akarsu, S., additional, Dirican, E. K., additional, Akin, K. O., additional, Kormaz, C., additional, Goktolga, U., additional, Ceyhan, S. T., additional, Kara, C., additional, Nadamoto, K., additional, Tarui, S., additional, Ida, M., additional, Sugihara, K., additional, Haruki, A., additional, Hukuda, A., additional, Morimoto, Y., additional, Albu, A., additional, Albu, D., additional, Sandu, L., additional, Kong, G., additional, Cheung, L., additional, Lok, I., additional, Pinto, A., additional, Teixeira, L., additional, Figueiredo, H., additional, Pires, I., additional, Silva Carvalho, J. L., additional, Pereira, M. L., additional, Faut, M., additional, de Zuniga, I., additional, Colaci, D., additional, Barrios, E., additional, Oubina, A., additional, Terrado Gil, G., additional, Motta, A., additional, Horton, M., additional, Sobral, F., additional, Gomez Pena, M., additional, Gleicher, N., additional, Barad, D. H., additional, Li, Y. P., additional, Zhao, H. C., additional, Spaczynski, R. Z., additional, Guzik, P., additional, Banaszewska, B., additional, Krauze, T., additional, Wykretowicz, A., additional, Wysocki, H., additional, Pawelczyk, L., additional, Sarikaya, E., additional, Gulerman, C., additional, Cicek, N., additional, Mollamahmutoglu, L., additional, Venetis, C. A., additional, Kolibianakis, E. M., additional, Toulis, K., additional, Goulis, D., additional, Loutradi, K., additional, Chatzimeletiou, K., additional, Papadimas, I., additional, Bontis, I., additional, Tarlatzis, B. C., additional, Schultze-Mosgau, A., additional, Griesinger, G., additional, Schoepper, B., additional, Cordes, T., additional, Diedrich, K., additional, Al-Hasani, S., additional, Gomez, R., additional, Jovanovic, V., additional, Sauer, C. M., additional, Shawber, C. J., additional, Sauer, M. V., additional, Kitajewski, J., additional, Zimmermann, R. C., additional, Bungum, L., additional, Jacobsson, A. K., additional, Rosen, F., additional, Becker, C., additional, Andersen, C. Y., additional, Guner, N., additional, Giwercman, A., additional, Kiapekou, E., additional, Zapanti, E., additional, Boukelatou, D., additional, Mavreli, T., additional, Bletsa, R., additional, Stefanidis, K., additional, Drakakis, P., additional, Mastorakos, G., additional, Loutradis, D., additional, Malhotra, N., additional, Sharma, V., additional, Kumar, S., additional, Roy, K. K., additional, Sharma, J. B., additional, Ferraretti, A., additional, Crippa, A., additional, Stanghellini, I., additional, Robles, F., additional, Serdynska-Szuster, M., additional, Kristensen, S. L., additional, Ernst, E., additional, Toft, G., additional, Olsen, S. F., additional, Bonde, J. P., additional, Vested, A., additional, Ramlau-Hansen, C. H., additional, Wang, F. F., additional, Qu, F., additional, Ding, G. L., additional, Gallot, V., additional, Genro, V., additional, Roux, I., additional, Scheffer, J. B., additional, Frydman, R., additional, Fanchin, R., additional, Kanta Goswami, S., additional, Banerjee, S., additional, Chakravarty, B. N., additional, Kabir, S. N., additional, Seeber, B. E., additional, Morandell, E., additional, Kurzthaler, D., additional, Wildt, L., additional, Dieplinger, H., additional, Tutuncu, L., additional, Bodur, S., additional, Dundar, O., additional, Ron - El, R., additional, Seger, R., additional, Komarovsky, D., additional, Kasterstein, E., additional, Komsky, A., additional, Maslansky, B., additional, Strassburger, D., additional, Ben-Ami, I., additional, Zhao, X. M., additional, Ni, R. M., additional, Lin, L., additional, Dong, M., additional, Tu, C. H., additional, He, Z. H., additional, Yang, D. Z., additional, Karamalegos, C., additional, Polidoropoulos, N., additional, Papanikopoulos, C., additional, Stefanis, P., additional, Argyrou, M., additional, Doriza, S., additional, Sisi, V., additional, Moschopoulou, M., additional, Karagianni, T., additional, Mentorou, C., additional, Economou, K., additional, Davies, S., additional, Mastrominas, M., additional, Gougeon, A., additional, De Los Santos, M. J., additional, Garcia-Laez, V., additional, Esteban, F., additional, Crespo, J., additional, Li, H. W. R., additional, Anderson, R. A., additional, Yeung, W. S. B., additional, Ho, P. C., additional, Ng, E. H. Y., additional, Yang, H. I., additional, Lee, K. E., additional, Seo, S. K., additional, Kim, H. Y., additional, Cho, S. H., additional, Choi, Y. S., additional, Lee, B. S., additional, Park, K. H., additional, Cho, D. J., additional, Hart, R., additional, Doherty, D., additional, Mori, T., additional, Hickey, M., additional, Sloboda, D., additional, Norman, R., additional, Huang, R. C., additional, Beilin, L., additional, Freiesleben, N., additional, Lossl, K., additional, Johannsen, T. H., additional, Loft, A., additional, Bangsboll, S., additional, Hougaard, D., additional, Friis-Hansen, L., additional, Christiansen, M., additional, Nyboe Andersen, A., additional, Thum, M. Y., additional, Abdalla, H., additional, Martinez-Salazar, J., additional, De la Fuente, G., additional, Kohls, G., additional, Garcia Velasco, J. A., additional, Yasmin, E., additional, Kukreja, S., additional, Barth, J., additional, Balen, A. H., additional, Esra, T., additional, Var, T., additional, Citil, A., additional, Dogan, M., additional, Messini, C. I., additional, Dafopoulos, K., additional, Chalvatzas, N., additional, Georgoulias, P., additional, Anifandis, G., additional, Messinis, I. E., additional, Celik, O., additional, Hascalik, S., additional, Celik, N., additional, Sahin, I., additional, Aydin, S., additional, Hanna, C. W., additional, Bretherick, K. L., additional, Liu, C. C., additional, Stephenson, M. D., additional, Robinson, W. P., additional, Louwers, Y. V., additional, Goodarzi, M. O., additional, Taylor, K. D., additional, Jones, M. R., additional, Cui, J., additional, Kwon, S., additional, Chen, Y. D. I., additional, Guo, X., additional, Stolk, L., additional, Uitterlinden, A. G., additional, Laven, J. S. E., additional, Azziz, R., additional, Navaratnarajah, R., additional, Grun, B., additional, Sinclair, J., additional, Dafou, D., additional, Gayther, S., additional, Timms, J. F., additional, Hardiman, P. J., additional, Ye, Y., additional, Wu, R., additional, Ou, J., additional, Kim, S. D., additional, Jee, B. C., additional, Lee, J. Y., additional, Suh, C. S., additional, Jung, J. H., additional, Opmeer, B. C., additional, Broeze, K. A., additional, Coppus, S. F., additional, Collins, J. A., additional, Den Hartog, J. E., additional, Land, J. A., additional, Van der Linden, P. J., additional, Marianowski, P., additional, Ng, E., additional, Van der Steeg, J. W., additional, Steures, P., additional, Strandell, A., additional, Mol, B. W., additional, Tarlatzi, T. B., additional, Kyrou, D., additional, Mertzanidou, A., additional, Fatemi, H. M., additional, Devroey, P., additional, Batenburg, T. E., additional, Konig, T. E., additional, Overbeek, A., additional, Schats, R., additional, Lambalk, C. B., additional, Carone, D., additional, Vizziello, G., additional, Vitti, A., additional, Chiappetta, R., additional, Topcu, H. O., additional, Yuksel, B., additional, Islimye, M., additional, Karakaya, J., additional, ozat, M., additional, Batioglu, S., additional, Kuchenbecker, W. K., additional, Groen, H., additional, Bolster, J. H., additional, van Asselt, S., additional, Wolffenbuettel, B. H., additional, Hoek, A., additional, Wu, Y., additional, Pan, H., additional, Chen, X., additional, Huang, H., additional, Zavos, A., additional, Verikouki, C., additional, Van Os, L., additional, Vink-Ranti, C. Q. J., additional, Rijnders, P. M., additional, Tucker, K. E., additional, Jansen, C. A. M., additional, Lucco, F., additional, Pozzobon, C., additional, Lara, E., additional, Galliano, D., additional, Ballesteros, A., additional, Ghoshdastidar, B., additional, Maity, S. P., additional, Ghoshdastidar, S., additional, Luna, M., additional, Vela, G., additional, Sandler, B., additional, Barritt, J., additional, Flisser, E. D., additional, Copperman, A. B., additional, Nogueira, D., additional, Prat, L., additional, Degoy, J., additional, Bonald, F., additional, Montagut, J., additional, Maity, S., additional, Chen, S., additional, Luo, C., additional, Zhen, H., additional, Shi, X., additional, Wu, F., additional, Ni, Y., additional, Merdassi, G., additional, Chaker, A., additional, Kacem, K., additional, Benmeftah, M., additional, Fourati, S., additional, Wahabi, D., additional, Zhioua, F., additional, Zhioua, A., additional, Saini, P., additional, Saini, A., additional, Sugiyama, R., additional, Nakagawa, K., additional, Nishi, Y., additional, Jyuen, H., additional, Kuribayashi, Y., additional, Inoue, M., additional, Jancar, N., additional, Vrtacnik Bokal, E., additional, Virant-Klun, I., additional, Lee, J. H., additional, Kim, S. G., additional, Cha, E. M., additional, Park, I. H., additional, Lee, K. H., additional, Dahdouh, E. M., additional, Desrosiers, P., additional, St-Michel, P., additional, Villeneuve, M., additional, Fontaine, J. Y., additional, Granger, L., additional, Ramon, O., additional, Burgos, J., additional, Abanto, E., additional, Gonzalez, M., additional, Mugica, J., additional, Corcostegui, B., additional, Tal, J., additional, Ziskind, G., additional, Ohel, G., additional, Paltieli, Y., additional, Paz, G., additional, Lewit, N., additional, Sendel, H., additional, Khouri, S., additional, Calderon, I., additional, van Gelder, P., additional, Al-Inany, H. G., additional, Antaki, R., additional, Dean, N., additional, Lapensee, L., additional, Racicot, M., additional, Menard, S., additional, Kadoch, I., additional, Meylaerts, L. J., additional, Dreesen, L., additional, Vandersteen, M., additional, Neumann, C., additional, Zollner, U., additional, Kato, K., additional, Segawa, T., additional, Kawachiya, S., additional, Okuno, T., additional, Kobayashi, T., additional, Takehara, Y., additional, Kato, O., additional, Jayaprakasan, K., additional, Nardo, L., additional, Hopkisson, J., additional, Campbell, B., additional, and Raine-Fenning, N., additional

Published
2010
Full Text
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32. Posters * Endometriosis, Endometrium and Implantation

Author

Jiang, Y., primary, Zhao, J., additional, Hua, M., additional, Zhen, X., additional, Yan, G., additional, Hu, Y., additional, Sun, H., additional, Selvaggi, L., additional, Zannoni, G. F., additional, Tagliaferri, V., additional, De Cicco, S., additional, Vellone, V. G., additional, Romualdi, D., additional, Lanzone, A., additional, Guido, M., additional, Fassbender, A., additional, Vodolazkaia, A. V., additional, Bossuyt, X. B., additional, Kyama, M. K., additional, Meuleman, C. M., additional, Peeraer, K. P., additional, Tomassetti, C. T., additional, D'Hooghe, T. M., additional, Lumini, A., additional, Nanni, L., additional, Manna, C., additional, Pappalardo, S., additional, Melin, A., additional, Lundholm, C., additional, Malki, N., additional, Swahn, M. L., additional, Sparen, P., additional, Bergqvist, A., additional, Crescenzi, F., additional, Farrag, A., additional, Sallam, H. N., additional, Zou, L., additional, Ding, G., additional, Zhang, R., additional, Sheng, J., additional, Huang, H., additional, von Kleinsorgen, C., additional, Wilson, T., additional, Thiel-Moder, U., additional, Ebert, A. D., additional, Reinfandt, M., additional, Papadopolous, T., additional, Melo, A. S., additional, Rodrigues, J. K., additional, Dib, L. A., additional, Andrade, A. Z., additional, Donabela, F. C., additional, Ferriani, R. A., additional, Navarro, P. A., additional, Tocci, A., additional, Royo, P., additional, Lucchini, C., additional, Ramos, P., additional, Alcazar, J. L., additional, Habara, T., additional, Terada, S., additional, Yoshioka, N., additional, Hayashi, N., additional, Haouzi, D., additional, Assou, S., additional, Monzo, C., additional, Anahory, T., additional, Dechaud, H., additional, De Vos, J., additional, Hamamah, S., additional, Gonzalez-Ramos, R., additional, Rojas, C., additional, Rocco, J., additional, Poch, A., additional, Sovino, H., additional, Kohen, P., additional, Munoz, A., additional, Devoto, L., additional, Aygen, M. A., additional, Atakul, T., additional, Oner, G., additional, Ozgun, M. T., additional, Sahin, Y., additional, Ozturk, F., additional, Li, R., additional, Qiao, J., additional, Zhylkova, I., additional, Feskov, A., additional, Feskova, I., additional, Somova, O., additional, Chumakova, N., additional, Bontekoe, S., additional, Blake, D., additional, Heineman, M. J., additional, Williams, E. C., additional, Johnson, N. P., additional, Motta, A., additional, Colaci, D., additional, Horton, M., additional, Faut, M., additional, Bisioli, C., additional, Kopcow, L., additional, de Zuniga, I., additional, Wiener-Megnazi, Z., additional, Khaytov, M., additional, Lahav - Baratz, S., additional, Shiloh, H., additional, Koifman, M., additional, Oslander, R., additional, Dirnfeld, M., additional, Sundqvist, J., additional, Andersson, K. L., additional, Scarselli, G., additional, Gemzell-Danielsson, K., additional, Lalitkumar, P. G. L., additional, Tokushige, N., additional, Markham, R., additional, Crossett, B., additional, Ahn, S., additional, Nelaturi, V., additional, Khan, A., additional, Fraser, I. S., additional, Van Vaerenbergh, I., additional, Fatemi, H. M., additional, Blockeel, C., additional, Van Lommel, L., additional, In't Veld, P., additional, Schuit, F., additional, Kolibianakis, E. M., additional, Devroey, P., additional, Bourgain, C., additional, Sugino, N., additional, Tamura, I., additional, Lee, R., additional, Maekawa, R., additional, Gelbaya, T., additional, Gordts, S., additional, D'Hooghe, T. N., additional, Gergolet, M., additional, Nardo, L. G., additional, Yu, H., additional, Wang, H., additional, Lee, C., additional, Soong, Y., additional, Kremenska, Y., additional, Masliy, Y., additional, Goncharova, Y., additional, Kremenskoy, M., additional, Veselovskyy, V., additional, Zukin, V., additional, Sudoma, I., additional, Delgado-Rosas, F., additional, Gomez, R., additional, Tamarit, S., additional, Abad, A., additional, Simon, C., additional, Pellicer, A., additional, Racicot, M., additional, Dean, N. L., additional, Antaki, R., additional, Menard, S., additional, Kadoch, I. J., additional, Garcia-Guzman, R., additional, Cabrera Romero, L., additional, Hernandez, J., additional, Palumbo, A., additional, Marshall, E., additional, Lowry, J., additional, Maybin, J. A., additional, Collins, F., additional, Critchley, H. O. D., additional, Saunders, P. T. K., additional, Chaudhury, K., additional, Jana, S. K., additional, Banerjee, P., additional, Mukherjee, S., additional, Chakravarty, B. N., additional, Allegra, A., additional, Marino, A., additional, Lama, A., additional, Santoro, A., additional, Agueli, C., additional, Mazzola, S., additional, Volpes, A., additional, Delvoux, B., additional, de Graaff, A. A., additional, Kyama, C. M., additional, Dunselman, G. A. J., additional, Romano, A., additional, Caccavo, D., additional, Pellegrino, N. M., additional, Totaro, I., additional, Panzarino, M., additional, Nardelli, C., additional, Depalo, R., additional, Flores, R., additional, Montanana, V., additional, Monzo, A., additional, Polo, P., additional, Garcia-Gimeno, T., additional, Cabo, A., additional, Rubio, J. M., additional, Beets, G. L., additional, van Lankveld, J. J., additional, Kim, H. Y., additional, Lee, B. S., additional, Cho, S. H., additional, Choi, Y. S., additional, Seo, S. K., additional, Lee, K. E., additional, Yang, H. I., additional, Abubakirov, A., additional, Vacheyshvili, T., additional, Krechetova, L., additional, Ziganshina, M., additional, Demura, T., additional, Nazarenko, T., additional, Fulop, I., additional, Rucz, A., additional, Herczegh, S. Z., additional, Ujvari, A., additional, Takacs, S. Z., additional, Szakonyi, T., additional, Lopez - Muniz, A., additional, Zamora, L., additional, Serra, O., additional, Guix, C., additional, Lopez-Teijon, M., additional, Benadiva, C., additional, Alvarez, J. G., additional, Goudakou, M., additional, Karkanaki, A., additional, Kalogeraki, A., additional, Mataliotakis, I., additional, Kalogiannidis, I., additional, Prapas, I., additional, Hosie, M., additional, Thomson, K. J., additional, Penny, C. B., additional, Penny, C., additional, Hosie, M. J., additional, McKinnon, B., additional, Klaeser, B., additional, Bersinger, N., additional, Mueller, M. D., additional, Horcajadas, J. A., additional, Martinez-Conejero, J. A., additional, Montesinos, M., additional, Morgan, M., additional, Fortuno, S., additional, Yi, K. W., additional, Shin, J. H., additional, Park, H. T., additional, Kim, T., additional, Kim, S. H., additional, Hur, J. Y., additional, Chan, R. W. S., additional, Chan, Y. Y., additional, Ng, E. H. 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Published
2010
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49. Evaluation of Thermal Support during Anesthesia Induction on Body Temperature in C57BL/6 and Nude Mice.

Author

Gaskill BN, Boykin C, Zuniga I, Maynard K, and Scorrano F

Subjects
Animals, Male, Mice, Female, Isoflurane, Heating methods, Hot Temperature adverse effects, Anesthesia veterinary, Mice, Inbred C57BL, Mice, Nude, Body Temperature
Abstract

Heat supplementation during surgery is a common practice; however, thermal support is not commonly used during anesthesia induction. Mice lose body temperature quickly, and air movement can exacerbate this, potentially putting mice at a thermal deficit before surgery. Whether the method of warming during induction affects overall heat loss during anesthesia is unknown. We hypothesized that the method of heating would affect body temperature (Tb) during anesthesia induction, maintenance, recovery, and once placed back on the rack. Mice (C57BL/6NHsd-6M/6F [C57BL/6]; Hsd:Athymic Nude-Foxn1nu [Nude]; N = 24;12M/12F) were assigned to a treatment in a factorial design: thermal chamber (TC; ambient temperature [Ta] = 28.8°C); heating pad (HP; induction chamber placed on an electric heating pad;Ta = 28.4°C); and control (Ctrl; Ta = 21.6°C). During induction, one mouse at a time was anesthetized with isoflurane over a 3min period and then maintained under anesthesia for 10min on a hot water heating pad (33 °C). Then isoflurane was stopped and time to ambulation was recorded. Tb and activity were tracked in the home cage on the rack before and after anesthesia. During induction, Ctrl mice lost significantly more heat (-2.8 °C) than did TC (+0.2 °C) and HP mice (+0.1 °C) but TC and HP were not different. During anesthesia maintenance, Ctrl mice regained 1 °C, but their Tb was still lower than that of the treated groups. Nude mice consistently had a lower Tb than C57BL/6 mice, regardless of treatment or anesthesia phase. C57BL/6 Ctrl mice took longer to ambulate than either HP or TC mice, but the method of heating did not differentially affect Nude mice. In general, C57BL/6 as compared with Nude and females as compared with males were comparatively more active and had higher Tb during certain times of day, regardless of the heating methods. Overall, our findings support the provision of heat during anesthesia induction, regardless of method, to reduce overall Tb loss during a short anesthesia event.

Published
2024
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50. Increased virus dissemination leads to enhanced lung injury but not inflammation during influenza-associated secondary bacterial infection.

Author

Smith AP, Lane LC, Ramirez Zuniga I, Moquin DM, Vogel P, and Smith AM

Abstract

Secondary bacterial infections increase influenza-related morbidity and mortality, particularly if acquired after 5-7 d from the viral onset. Synergistic host responses and direct pathogen-pathogen interactions are thought to lead to a state of hyperinflammation, but the kinetics of the lung pathology have not yet been detailed, and identifying the contribution of different mechanisms to disease is difficult because these may change over time. To address this gap, we examined host-pathogen and lung pathology dynamics following a secondary bacterial infection initiated at different time points after influenza within a murine model. We then used a mathematical approach to quantify the increased virus dissemination in the lung, coinfection time-dependent bacterial kinetics, and virus-mediated and postbacterial depletion of alveolar macrophages. The data showed that viral loads increase regardless of coinfection timing, which our mathematical model predicted and histomorphometry data confirmed was due to a robust increase in the number of infected cells. Bacterial loads were dependent on the time of coinfection and corresponded to the level of IAV-induced alveolar macrophage depletion. Our mathematical model suggested that the additional depletion of these cells following the bacterial invasion was mediated primarily by the virus. Contrary to current belief, inflammation was not enhanced and did not correlate with neutrophilia. The enhanced disease severity was correlated to inflammation, but this was due to a nonlinearity in this correlation. This study highlights the importance of dissecting nonlinearities during complex infections and demonstrated the increased dissemination of virus within the lung during bacterial coinfection and simultaneous modulation of immune responses during influenza-associated bacterial pneumonia., Competing Interests: None declared., (© The Author(s) 2022. Published by Oxford University Press on behalf of FEMS.)

Published
2022
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