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1. Diagnostic yield of a proactive strategy for early detection of cardiovascular disease versus usual care in adults with type 2 diabetes or chronic obstructive pulmonary disease in primary care in the Netherlands (RED-CVD): a multicentre, pragmatic, cluster-randomised, controlled trial

Author

Groenewegen, Amy, Zwartkruis, Victor W, Rienstra, Michiel, Zuithoff, Nicolaas P A, Hollander, Monika, Koffijberg, Hendrik, Oude Wolcherink, Martijn, Cramer, Maarten J, van der Schouw, Yvonne T, Hoes, Arno W, Rutten, Frans H, and de Boer, Rudolf A

Published
2024
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3. Long-Term Effectiveness and Reasons for Discontinuation of Dupilumab in Patients With Atopic Dermatitis.

Author

Boesjes, Celeste M., Kamphuis, Esmé, de Graaf, Marlies, Spekhorst, Lotte S., Haeck, Inge, van der Gang, Lian F., Loman, Laura, Zuithoff, Nicolaas P. A., Dekkers, Coco, van der Rijst, Lisa P., Romeijn, Geertruida L. E., Oosting, Albert J., Gostynksi, Antoni, van Lynden-van Nes, Anneke M. T., Tupker, Ron A., van Tuyll van Serooskerken, Anne-Moon, Flinterman, Annebeth, Politiek, Klaziena, Touwslager, Wouter R. H., and Christoffers, Wianda A.

Published
2024
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4. Reliability of mandibular range of motion measurements in healthy children.

Author

de Sonnaville, Willemijn F. C., Steenks, Michel H., Verkouteren, Daan R. C., Zuithoff, Nicolaas P. A., Wulffraat, Nico M., Rosenberg, Antoine J. W. P., and Speksnijder, Caroline M.

Subjects
CROSS-sectional method, TEMPOROMANDIBULAR joint, RESEARCH evaluation, QUESTIONNAIRES, MOUTH physiology, INTRACLASS correlation, MANDIBLE, RANGE of motion of joints, CHILDREN
Abstract

Background: Mandibular range of motion (MROM) variables are widely used to evaluate oral function. Objective: The aim of this study was to establish the reliability of MROM variables in healthy children. Methods: In this cross‐sectional study, healthy children were examined 2 weeks apart. The following MROM variables were established: active maximum interincisal opening (AMIO), passive maximum interincisal opening (PMIO), protrusion and left and right laterotrusion. The reliability of the MROM measurements was determined by analysing the intra‐class correlation coefficient (ICC), standard error of measurement (SEM), smallest detectable change (SDC) and limits of agreement (LoA). Results: A total of 167 healthy children were examined. The ICC indicated good reliability for AMIO (0.885); excellent reliability for PMIO (0.925); and moderate reliability for protrusion (0.578), laterotrusion left (0.601) and laterotrusion right (0.634). The SDC was 0.9 mm for AMIO, 0.4 mm for PMIO, 2.2 mm for protrusion, 1.6 mm for laterotrusion left and 1.4 mm for laterotrusion right. The LoA was −5.67 to 5.82 for AMIO, −3.90 to 3.57 for PMIO, −3.89 to 3.55 for protrusion, −2.99 to 2.77 for laterotrusion left, and − 2.71 to 2.77 for laterotrusion right. Conclusions: AMIO and PMIO measurements are both highly reliable in healthy children. The low SDC indicate that AMIO and PMIO are promising longitudinal measurements. Protrusion and laterotrusion measurements had moderate reliability. These results support our clinical recommendation to measure AMIO rather than PMIO, as PMIO is more difficult and more time‐consuming to perform than AMIO. [ABSTRACT FROM AUTHOR]

Published
2024
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5. Topical or oral antibiotics in childhood acute otitis media and ear discharge: a randomized controlled non-inferiority trial.

Author

Hullegie, Saskia, Damoiseaux, Roger A M J, Hay, Alastair D, Zuithoff, Nicolaas P A, Dongen, Thijs M A van, Little, Paul, Schilder, Anne G M, and Venekamp, Roderick P

Subjects
ACUTE otitis media, EARACHE, RANDOMIZED controlled trials, LIKERT scale, OPTIMAL stopping (Mathematical statistics), OTITIS media
Abstract

Background Current guidance suggests oral antibiotics can be considered for children with acute otitis media (AOM) and ear discharge, but there is an absence of evidence regarding the relative effectiveness of antibiotic-corticosteroid eardrops. Aim To establish whether antibiotic-corticosteroid eardrops are non-inferior to oral antibiotics in children with AOM and ear discharge. Design and setting Open randomized controlled non-inferiority trial set in Dutch primary care. Methods Children were randomized to hydrocortisone-bacitracin-colistin eardrops (five drops, three times per day in the discharging ear(s)) or amoxicillin suspension (50 mg per kilogram of body weight per day, divided over three doses administered orally) for 7 days. The primary outcome was the proportion of children with resolution of ear pain and fever at day 3. Results Between December 2017 and March 2023, 58 of the planned 350 children were recruited due to slow accrual for various reasons. Children assigned to eardrops (n  = 26) had lower resolution rates of ear pain and fever at 3 days compared to those receiving oral antibiotics (n  = 31): 42% vs 65%; adjusted risk difference 20.3%, 95% confidence interval −5.3% to 41.9%), longer parent-reported ear discharge (6 vs 3 days; P  = .04), and slightly higher mean ear pain scores (Likert scale 0–6) over days 1–3 (2.1 vs 1.4, P  = .02), but received fewer oral antibiotic courses in 3months (11 for 25 children vs 33 for 30 children), and had less GI upset and rash (12% vs 32% and 8% vs 16%, respectively). Conclusion Early termination stopped us from determining non-inferiority of antibiotic-corticosteroid eardrops. Our limited data, requiring confirmation, suggest that oral antibiotics may be more effective than antibiotic-corticosteroid eardrops in resolving symptoms and shortening the duration of ear discharge. [ABSTRACT FROM AUTHOR]

Published
2024
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6. Did aetiology matter in illness duration and complications in patients presenting in primary care with acute respiratory tract infections early in the COVID-19 pandemic: An observational study in nine countries

Author

HAG Onderzoek, Infection & Immunity, Child Health, Biostatistiek Onderzoek, CTM & Statistical consultation, Other research (not in main researchprogram), HAG Infectieziekten, Ecraid, JC onderzoeksprogramma Infectieziekten, Venekamp, Roderick P, Eijkemans, Marinus J C, Zuithoff, Nicolaas P A, Böhmer, Femke, Chlabicz, Slawomir, Colliers, Annelies, García-Sangenís, Ana, Malania, Lile, Pauer, Jozsef, Tomacinschii, Angela, Verheij, Theo J, Goossens, Herman, Vellinga, Akke, Butler, Christopher C, van der Velden, Alike W, HAG Onderzoek, Infection & Immunity, Child Health, Biostatistiek Onderzoek, CTM & Statistical consultation, Other research (not in main researchprogram), HAG Infectieziekten, Ecraid, JC onderzoeksprogramma Infectieziekten, Venekamp, Roderick P, Eijkemans, Marinus J C, Zuithoff, Nicolaas P A, Böhmer, Femke, Chlabicz, Slawomir, Colliers, Annelies, García-Sangenís, Ana, Malania, Lile, Pauer, Jozsef, Tomacinschii, Angela, Verheij, Theo J, Goossens, Herman, Vellinga, Akke, Butler, Christopher C, and van der Velden, Alike W

Published
2024

7. Influence of pathogenic filaggrin variants on dupilumab treatment in atopic dermatitis

Author

MS Dermatologie/Allergologie, Infection & Immunity, Biostatistiek Onderzoek, Other research (not in main researchprogram), Clabbers, Julia, Boesjes, Celeste, Spekhorst, Lotte, van Gisbergen, Marike W, Maas, Emmy, Marshall, Josephine, Janssen, Renske, Janssen, Miranda, Zuithoff, Nicolaas P A, Steijlen, Peter, de Graaf, Marlies, van Geel, Michel, de Bruin-Weller, Marjolein, Gostyński, Antoni, MS Dermatologie/Allergologie, Infection & Immunity, Biostatistiek Onderzoek, Other research (not in main researchprogram), Clabbers, Julia, Boesjes, Celeste, Spekhorst, Lotte, van Gisbergen, Marike W, Maas, Emmy, Marshall, Josephine, Janssen, Renske, Janssen, Miranda, Zuithoff, Nicolaas P A, Steijlen, Peter, de Graaf, Marlies, van Geel, Michel, de Bruin-Weller, Marjolein, and Gostyński, Antoni

Published
2024

8. Effect of dupilumab on asthma and aeroallergen sensitization in pediatric atopic dermatitis patients: Results of the BioDay registry

Author

Infection & Immunity, MS Dermatologie/Allergologie, CTM & Statistical consultation, Other research (not in main researchprogram), Rijst, Lisa P van der, Groot, Karin M de Winter-de, Zuithoff, Nicolaas P A, de Bruin-Weller, Marjolein S, de Graaf, Marlies, Infection & Immunity, MS Dermatologie/Allergologie, CTM & Statistical consultation, Other research (not in main researchprogram), Rijst, Lisa P van der, Groot, Karin M de Winter-de, Zuithoff, Nicolaas P A, de Bruin-Weller, Marjolein S, and de Graaf, Marlies

Published
2024

9. Diagnostic yield of a proactive strategy for early detection of cardiovascular disease versus usual care in adults with type 2 diabetes or chronic obstructive pulmonary disease in primary care in the Netherlands (RED-CVD): a multicentre, pragmatic, cluster-randomised, controlled trial

Author

HAG Hart- Vaatziekten, Biostatistiek Onderzoek, Other research (not in main researchprogram), HAG Zorginnovatieonderzoek, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Team Medisch, Cardiovasculaire Epi Team 1, Directie Raad van Bestuur, Groenewegen, Amy, Zwartkruis, Victor W, Rienstra, Michiel, Zuithoff, Nicolaas P A, Hollander, Monika, Koffijberg, Hendrik, Oude Wolcherink, Martijn, Cramer, Maarten J, van der Schouw, Yvonne T, Hoes, Arno W, Rutten, Frans H, de Boer, Rudolf A, HAG Hart- Vaatziekten, Biostatistiek Onderzoek, Other research (not in main researchprogram), HAG Zorginnovatieonderzoek, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Team Medisch, Cardiovasculaire Epi Team 1, Directie Raad van Bestuur, Groenewegen, Amy, Zwartkruis, Victor W, Rienstra, Michiel, Zuithoff, Nicolaas P A, Hollander, Monika, Koffijberg, Hendrik, Oude Wolcherink, Martijn, Cramer, Maarten J, van der Schouw, Yvonne T, Hoes, Arno W, Rutten, Frans H, and de Boer, Rudolf A

Published
2024

11. The reliability and validity of the juvenile idiopathic arthritis magnetic resonance scoring system for temporomandibular joints.

Author

de Sonnaville, Willemijn F.C., Speksnijder, Caroline M., Zuithoff, Nicolaas P.A., ter Horst, Simone A.J., Nap, Frank J., Wulffraat, Nico M., Steenks, Michel H., and Rosenberg, Antoine J.W.P.

Subjects
JUVENILE idiopathic arthritis, TEMPOROMANDIBULAR joint, CONTRAST-enhanced magnetic resonance imaging, MAGNETIC resonance, INTER-observer reliability
Abstract

In children with juvenile idiopathic arthritis (JIA), the temporomandibular joint (TMJ) can be involved. To prevent TMJ damage due to inflammation, early recognition is important, for which contrast-enhanced magnetic resonance imaging (MRI) is the gold standard. In this study, the interobserver reliability and construct validity of the Juvenile Idiopathic Arthritis Magnetic Resonance Scoring System for Temporomandibular Joints (JAMRIS-TMJ) was assessed. Two radiologists independently examined 38 MRIs using the JAMRIS-TMJ scoring system. Inter-observer reliability was assessed by Cohen's (weighted) kappa (κ), 95% confidence intervals (CIs) and absolute agreement (%). Construct validity was assessed by correlation between the JAMRIS-TMJ items and TMJ involvement, active maximum interincisal mouth opening (AMIO), and anterior maximum voluntary bite force (AMVBF). The interobserver reliability for the JAMRIS-TMJ items varied from poor to good (κ = 0.18–0.61). Joint enhancement had the highest reliability (κ = 0.61). Correlations were found between TMJ involvement, AMIO, and the JAMRIS-TMJ items, although variation between radiologists and TMJ side existed. No correlation was found between AMVBF and the JAMRIS-TMJ items for both radiologists. The strongest correlations were found between most of the JAMRIS-TMJ items and AMIO. Our findings support the utility of AMIO as a clinical measure of TMJ status in children with JIA. [ABSTRACT FROM AUTHOR]

Published
2024
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12. Dupilumab induces a significant decrease of food specific immunoglobulin E levels in pediatric atopic dermatitis patients.

Author

van der Rijst, Lisa P., Hilbrands, Michelle S., Zuithoff, Nicolaas P. A., de Bruin‐Weller, Marjolein S., Knulst, André C., Le, Thuy‐My, and de Graaf, Marlies

Subjects
IMMUNOGLOBULIN E, ATOPIC dermatitis, DUPILUMAB, ALMOND, FOOD allergy, IMMUNOGLOBULIN class switching, NATURAL history
Abstract

This article explores the impact of dupilumab, a monoclonal antibody used to treat atopic dermatitis, on food-specific immunoglobulin E (sIgE) levels in pediatric patients with moderate to severe atopic dermatitis. The study found that dupilumab led to a significant decrease in sIgE levels for various food allergens in these patients. This research is valuable for understanding the potential benefits of dupilumab in treating food allergies in young patients with atopic dermatitis. However, more research is needed to fully comprehend the effects of dupilumab in pediatric patients. [Extracted from the article]

Published
2024
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13. Effect of dupilumab on asthma and aeroallergen sensitization in pediatric atopic dermatitis patients: Results of the BioDay registry.

Author

Rijst, Lisa P. van der, Groot, Karin M. de Winter‐de, Zuithoff, Nicolaas P. A., de Bruin‐Weller, Marjolein S., and de Graaf, Marlies

Subjects
ATOPIC dermatitis, DUPILUMAB, FORCED expiratory volume, ASTHMA, ATOPY, ASTHMATICS, VOCAL cord dysfunction
Abstract

Background: Atopic dermatitis (AD) is frequently associated with asthma and allergic rhinitis (AR). Dupilumab is an effective treatment for pediatric AD, although the effect on atopic comorbidities in pediatric AD patients is limited. Objective: To investigate the prevalence of asthma and AR in pediatric AD patients starting dupilumab treatment and to evaluate the effect of dupilumab on these comorbidities. Methods: This study included pediatric AD patients (aged 3–17 years) treated with dupilumab between 2019 and 2023. Patients were screened at baseline by a pulmonologist for the presence of asthma and AR. Screening included evaluation of medical history and current symptoms, spirometry (including Forced Expiratory Volume in 1 s (FEV1)), Fractional exhaled Nitric Oxide (FeNO), and measurement of aeroallergen‐specific IgE levels. In patients diagnosed with comorbid asthma and/or AR, measurements were repeated at weeks 16 and 52. Spirometry measurements, FeNO, and aeroallergen‐specific IgE levels during treatment were analyzed using a covariance pattern model. Results: Eighty‐four patients were included. Asthma was diagnosed in 50 patients (59.5%) and AR in 72 patients (85.7%). Baseline FeNO levels were elevated in both patients with (29.0 ppb (95% CI 22.0–54.0)) and without asthma (26.0 ppb (95% CI 22.0–30.0)). During treatment, FeNO levels decreased (p <.001) and FEV1 scores increased (p <.001) in patients with asthma. In patients with asthma and/or AR, all aeroallergen‐specific IgE levels decreased between 61.3% and 89.1% at 52 weeks of treatment. Conclusion: One year of dupilumab treatment, primarily indicated for AD, resulted in a significant improvement in comorbid asthma and a profound decrease in aeroallergen‐specific IgE levels in patients with asthma and/or AR. [ABSTRACT FROM AUTHOR]

Published
2024
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14. Patient preferences for disposable and reusable vaginal specula and their willingness to compromise in the era of climate change: A cross‐sectional study

Author

Ten Buuren, Amber A. A., primary, Poolman, Tessa B., additional, Bongers, Marlies Y., additional, Bullens, Lauren M., additional, Van Hanegem, Nehalennia, additional, Klerkx, Wenche M., additional, Timmermans, Anne, additional, Zuithoff, Nicolaas P. A., additional, and Kwee, Anneke, additional

Published
2023
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18. Patient preferences for disposable and reusable vaginal specula and their willingness to compromise in the era of climate change: A cross‐sectional study.

Author

Ten Buuren, Amber A. A., Poolman, Tessa B., Bongers, Marlies Y., Bullens, Lauren M., Van Hanegem, Nehalennia, Klerkx, Wenche M., Timmermans, Anne, Zuithoff, Nicolaas P. A., and Kwee, Anneke

Subjects
PATIENT preferences, CLIMATE change, PATIENT satisfaction, CROSS-sectional method, PATIENT surveys
Abstract

Objective: To evaluate patient satisfaction on gynaecological examination with metal, plastic and biobased plastic vaginal specula, and to investigate whether patients are willing to compromise on comfort for a more sustainable healthcare system. Design: Cross‐sectional study: population‐based survey. Setting: Gynaecological outpatient clinics in five Dutch hospitals. Population: Patients during general gynaecology consultation hours. Methods: A survey containing two questions about patient demographics, four about comfort and five about sustainability and healthcare was distributed. Main outcome measures: Comfort score (scale 1–10). Secondary outcomes: (1) temperature, size and ease of insertion, (2) willingness to compromise for a more sustainable healthcare system. Results: In all, 196 patients completed the survey. Biobased plastic vaginal specula scored significantly higher on comfort than the metal ones (mean 8.03 ± 1.65 versus 7.26 ± 1.51 respectively; P < 0.001). The biobased plastic vaginal speculum is significantly the most comfortable on temperature, whereas the metal speculum is the least comfortable (P < 0.007). Most patients are willing to compromise on comfort or are open to the reuse of disposables to contribute to a more sustainable healthcare. The majority of patients (77%) urge healthcare organisations to combat climate change. Conclusions: There is a small but statistically significant difference in favour of a biobased plastic speculum regarding comfort score, although it might be questioned whether this is clinically relevant. Furthermore, patients are willing to compromise on comfort for a more sustainable healthcare, which should be a contributing factor in speculum selection. [ABSTRACT FROM AUTHOR]

Published
2024
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19. Salivary concentrations of secretory leukocyte protease inhibitor and matrix metallopeptidase-9 following a single bout of exercise are associated with intensity and hydration status

Author

Knipping, Karen, primary, Kartaram, Shirley W., additional, Teunis, Marc, additional, Zuithoff, Nicolaas P. A., additional, Buurman, Nicole, additional, M’Rabet, Laura, additional, van Norren, Klaske, additional, Witkamp, Renger, additional, Pieters, Raymond, additional, and Garssen, Johan, additional

Published
2023
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23. Successful tapering of dupilumab in patients with atopic dermatitis with low disease activity: a large pragmatic daily practice study from the BioDay registry

Author

Spekhorst, Lotte S, primary, Boesjes, Celeste M, additional, Loman, Laura, additional, Zuithoff, Nicolaas P A, additional, Bakker, Daphne S, additional, Kamphuis, Esmé, additional, Kamsteeg, Marijke, additional, Haeck, Inge M, additional, Oosting, Albert J, additional, van Lumig, Paula P M, additional, van Lynden-van Nes, Anneke M T, additional, Tupker, Ron A, additional, Flinterman, Annebeth, additional, Garritsen, Floor M, additional, Touwslager, Wouter R H, additional, de Bruin-Weller, Marjolein S, additional, Schuttelaar, Marie-Louise A, additional, and de Graaf, Marlies, additional

Published
2023
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25. Home telemonitoring versus hospital care in complicated pregnancies in the Netherlands: a randomised, controlled non-inferiority trial (HoTeL)

Author

Bekker, Mireille N, primary, Koster, Maria P H, additional, Keusters, Willem R, additional, Ganzevoort, Wessel, additional, de Haan-Jebbink, Jiska M, additional, Deurloo, Koen L, additional, Seeber, Laura, additional, van der Ham, David P, additional, Zuithoff, Nicolaas P A, additional, Frederix, Geert W J, additional, van den Heuvel, Josephus F M, additional, and Franx, Arie, additional

Published
2023
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26. Salivary concentrations of secretory leukocyte protease inhibitor and matrix metallopeptidase-9 following a single bout of exercise are associated with intensity and hydration status

Author

Knipping, Karen, Kartaram, Shirley W, Teunis, Marc, Zuithoff, Nicolaas P A, Buurman, Nicole, M'Rabet, Laura, van Norren, Klaske, Witkamp, Renger, Pieters, Raymond, Garssen, Johan, Knipping, Karen, Kartaram, Shirley W, Teunis, Marc, Zuithoff, Nicolaas P A, Buurman, Nicole, M'Rabet, Laura, van Norren, Klaske, Witkamp, Renger, Pieters, Raymond, and Garssen, Johan

Abstract

AIM: To investigate the effects of exercise on salivary concentrations of inflammatory markers by analyzing a panel of 25 inflammatory markers in subjects who had participated in bicycle ergometer tests varying in workload and hydration status.METHODS: Fifteen healthy young men (20-35 years) had performed 4 different exercise protocols of 1 hour duration in a randomly assigned cross-over design, preceded by a rest protocol. Individual workloads depended on participant's pre-assessed individual maximum workload (Wmax): rest (protocol 1), 70% Wmax in hydrated (protocol 2) and dehydrated (protocol 3) state, 50% Wmax (protocol 4) and intermittent 85%/55% Wmax in 2 min blocks (protocol 5). Saliva samples were collected before (T0) and immediately after exercise (T1), and at several time points after exercise (2 hours (T3), 3 hours (T4), 6 hours (T5) and 24 hours (T6)). Secretory Leukocyte Protease Inhibitor (SLPI), Matrix Metallopeptidase-9 (MMP-9) and lactoferrin was analyzed using a commercial ELISA kit, a panel of 22 cytokines and chemokines were analyzed using a commercial multiplex immunoassay. Data was analyzed using a multilevel mixed linear model, with multiple test correction.RESULTS: Among a panel of 25 inflammatory markers, SLPI concentrations were significantly elevated immediately after exercise in all protocols compared to rest and higher concentrations reflected the intensity of exercise and hydration status. MMP-9 showed a significant increase in the 70% Wmax dehydrated, 50% Wmax and intermittent protocols.CONCLUSIONS: Salivary concentrations of SLPI and MMP-9 seem associated with exercise intensity and hydration status and may offer non-invasive biomarkers to study (local) inflammatory responses to different exercise intensities in human studies.

Published
2023

27. Salivary concentrations of secretory leukocyte protease inhibitor and matrix metallopeptidase-9 following a single bout of exercise are associated with intensity and hydration status

Author

Afd Pharmacology, IRAS OH Toxicology, IRAS – One Health Toxicology, Knipping, Karen, Kartaram, Shirley W, Teunis, Marc, Zuithoff, Nicolaas P A, Buurman, Nicole, M'Rabet, Laura, van Norren, Klaske, Witkamp, Renger, Pieters, Raymond, Garssen, Johan, Afd Pharmacology, IRAS OH Toxicology, IRAS – One Health Toxicology, Knipping, Karen, Kartaram, Shirley W, Teunis, Marc, Zuithoff, Nicolaas P A, Buurman, Nicole, M'Rabet, Laura, van Norren, Klaske, Witkamp, Renger, Pieters, Raymond, and Garssen, Johan

Published
2023

28. Clinically Established Temporomandibular Involvement in Adults With Juvenile Idiopathic Arthritis

Author

MKA/BT Onderzoek, MS Hoofd-Hals Chirurgische Oncologie, Cancer, JC onderzoeksprogramma Kanker, Biostatistiek Onderzoek, Other research (not in main researchprogram), MS Reumatologie/Immunologie/Infectie, Infection & Immunity, Immuno/reuma ERN, de Sonnaville, Willemijn F C, Speksnijder, Caroline M, Zuithoff, Nicolaas P A, Heijstek, Marloes W, Wulffraat, Nico M, Steenks, Michel H, Rosenberg, Antoine J W P, MKA/BT Onderzoek, MS Hoofd-Hals Chirurgische Oncologie, Cancer, JC onderzoeksprogramma Kanker, Biostatistiek Onderzoek, Other research (not in main researchprogram), MS Reumatologie/Immunologie/Infectie, Infection & Immunity, Immuno/reuma ERN, de Sonnaville, Willemijn F C, Speksnijder, Caroline M, Zuithoff, Nicolaas P A, Heijstek, Marloes W, Wulffraat, Nico M, Steenks, Michel H, and Rosenberg, Antoine J W P

Published
2023

29. Successful tapering of dupilumab in patients with atopic dermatitis with low disease activity: a large pragmatic daily practice study from the BioDay registry

Author

MS Dermatologie/Allergologie, Infection & Immunity, Biostatistiek Onderzoek, Other research (not in main researchprogram), Unit Opleiding Dermatologie, Spekhorst, Lotte S, Boesjes, Celeste M, Loman, Laura, Zuithoff, Nicolaas P A, Bakker, Daphne S, Kamphuis, Esmé, Kamsteeg, Marijke, Haeck, Inge, Oosting, Albert J, van Lumig, Paula P M, van Lynden-van Nes, Anneke M T, Tupker, Ron A, Flinterman, Annebeth, Garritsen, Floor M, Touwslager, Wouter R H, de Bruin-Weller, Marjolein S, Schuttelaar, Marie-Louise, de Graaf, Marlies, MS Dermatologie/Allergologie, Infection & Immunity, Biostatistiek Onderzoek, Other research (not in main researchprogram), Unit Opleiding Dermatologie, Spekhorst, Lotte S, Boesjes, Celeste M, Loman, Laura, Zuithoff, Nicolaas P A, Bakker, Daphne S, Kamphuis, Esmé, Kamsteeg, Marijke, Haeck, Inge, Oosting, Albert J, van Lumig, Paula P M, van Lynden-van Nes, Anneke M T, Tupker, Ron A, Flinterman, Annebeth, Garritsen, Floor M, Touwslager, Wouter R H, de Bruin-Weller, Marjolein S, Schuttelaar, Marie-Louise, and de Graaf, Marlies

Published
2023

30. Effect of a multifaceted antibiotic stewardship intervention to improve antibiotic prescribing for suspected urinary tract infections in frail older adults (ImpresU): pragmatic cluster randomised controlled trial in four European countries

Author

HAG Infectieziekten, Infection & Immunity, HAG Zorginnovatieonderzoek, Biostatistiek Onderzoek, Other research (not in main researchprogram), Hartman, Esther A.R., van de Pol, Alma C., Heltveit-Olsen, Silje Rebekka, Lindbæk, Morten, Høye, Sigurd, Lithén, Sara Sofia, Sundvall, Pär Daniel, Sundvall, Sofia, Arnljots, Egill Snaebjörnsson, Gunnarsson, Ronny, Kowalczyk, Anna, Godycki-Cwirko, Maciek, Platteel, Tamara N., Groen, Wim G., Monnier, Annelie A., Zuithoff, Nicolaas P., Verheij, Theo J.M., Hertogh, Cees M.P.M., HAG Infectieziekten, Infection & Immunity, HAG Zorginnovatieonderzoek, Biostatistiek Onderzoek, Other research (not in main researchprogram), Hartman, Esther A.R., van de Pol, Alma C., Heltveit-Olsen, Silje Rebekka, Lindbæk, Morten, Høye, Sigurd, Lithén, Sara Sofia, Sundvall, Pär Daniel, Sundvall, Sofia, Arnljots, Egill Snaebjörnsson, Gunnarsson, Ronny, Kowalczyk, Anna, Godycki-Cwirko, Maciek, Platteel, Tamara N., Groen, Wim G., Monnier, Annelie A., Zuithoff, Nicolaas P., Verheij, Theo J.M., and Hertogh, Cees M.P.M.

Published
2023

31. Effectiveness of analgesic ear drops as add-on treatment to oral analgesics in children with acute otitis media: study protocol of the OPTIMA pragmatic randomised controlled trial

Author

Infection & Immunity, HAG Infectieziekten, Huisartsopleiding, Onderzoek, Child Health, HEE, Circulatory Health, JC onderzoeksprogramma Methodologie, Biostatistiek Onderzoek, Other research (not in main researchprogram), Epi Infectieziekten Team 1, HAG Onderzoek, JC onderzoeksprogramma Infectieziekten, de Sévaux, Joline L H, Damoiseaux, Roger A M J, Hullegie, Saskia, Sanders, Elisabeth A M, de Wit, G Ardine, Zuithoff, Nicolaas P A, Yardley, Lucy, Anthierens, Sibyl, Little, Paul, Hay, Alastair D, Schilder, Anne G M, Venekamp, Roderick P, Infection & Immunity, HAG Infectieziekten, Huisartsopleiding, Onderzoek, Child Health, HEE, Circulatory Health, JC onderzoeksprogramma Methodologie, Biostatistiek Onderzoek, Other research (not in main researchprogram), Epi Infectieziekten Team 1, HAG Onderzoek, JC onderzoeksprogramma Infectieziekten, de Sévaux, Joline L H, Damoiseaux, Roger A M J, Hullegie, Saskia, Sanders, Elisabeth A M, de Wit, G Ardine, Zuithoff, Nicolaas P A, Yardley, Lucy, Anthierens, Sibyl, Little, Paul, Hay, Alastair D, Schilder, Anne G M, and Venekamp, Roderick P

Published
2023

32. The positive effect of dupilumab on comorbid asthma in patients with atopic dermatitis

Author

MS Dermatologie/Allergologie, Infection & Immunity, Biostatistiek Onderzoek, Other research (not in main researchprogram), Spekhorst, Lotte S, de Graaf, Marlies, van der Rijst, Lisa P, Zuithoff, Nicolaas P A, Schweizer, René C, Kamsteeg, Marijke, Haeck, Inge, van Lynden-van Nes, Anneke M T, van Lumig, Paula, Romeijn, Geertruida L E, Schuttelaar, Marie-Louise, de Bruin-Weller, Marjolein S, MS Dermatologie/Allergologie, Infection & Immunity, Biostatistiek Onderzoek, Other research (not in main researchprogram), Spekhorst, Lotte S, de Graaf, Marlies, van der Rijst, Lisa P, Zuithoff, Nicolaas P A, Schweizer, René C, Kamsteeg, Marijke, Haeck, Inge, van Lynden-van Nes, Anneke M T, van Lumig, Paula, Romeijn, Geertruida L E, Schuttelaar, Marie-Louise, and de Bruin-Weller, Marjolein S

Published
2023

33. Effectiveness of Upadacitinib in Patients with Atopic Dermatitis including those with Inadequate Response to Dupilumab and/or Baricitinib: Results from the BioDay Registry

Author

MS Dermatologie/Allergologie, Infection & Immunity, Biostatistiek Onderzoek, Other research (not in main researchprogram), Unit Opleiding Dermatologie, Boesjes, Celeste M, Van der Gang, Liana F, Zuithoff, Nicolaas P A, Bakker, Daphne S, Spekhorst, Lotte S, Haeck, Inge, Kamsteeg, Marijke, De Graaf, Marlies, De Bruin-Weller, Marjolein S, MS Dermatologie/Allergologie, Infection & Immunity, Biostatistiek Onderzoek, Other research (not in main researchprogram), Unit Opleiding Dermatologie, Boesjes, Celeste M, Van der Gang, Liana F, Zuithoff, Nicolaas P A, Bakker, Daphne S, Spekhorst, Lotte S, Haeck, Inge, Kamsteeg, Marijke, De Graaf, Marlies, and De Bruin-Weller, Marjolein S

Published
2023

34. Generalizability of the Results of Efficacy Trials in First-Episode Schizophrenia: Comparing Outcome and Study Discontinuation of Groups of Participants in the Optimization of Treatment and Management of Schizophrenia in Europe (OPTiMiSE) Trial

Author

Onderzoeksgroep 9, Brain, Biostatistiek Onderzoek, Other research (not in main researchprogram), Research IT, Nasib, Lyliana G, Winter-van Rossum, Inge, Zuithoff, Nicolaas P A, Boudewijns, Zimbo S R M, Leucht, Stefan, Kahn, René S, Onderzoeksgroep 9, Brain, Biostatistiek Onderzoek, Other research (not in main researchprogram), Research IT, Nasib, Lyliana G, Winter-van Rossum, Inge, Zuithoff, Nicolaas P A, Boudewijns, Zimbo S R M, Leucht, Stefan, and Kahn, René S

Published
2023

35. Dupilumab has a profound effect on specific-IgE levels of several food allergens in atopic dermatitis patients

Author

MS Dermatologie/Allergologie, Infection & Immunity, Biostatistiek Onderzoek, Other research (not in main researchprogram), Spekhorst, Lotte S, van der Rijst, Lisa P, de Graaf, Marlies, van Megen, Maxime, Zuithoff, Nicolaas P A, Knulst, André C, de Bruin-Weller, Marjolein S, Le, Thuy-My, MS Dermatologie/Allergologie, Infection & Immunity, Biostatistiek Onderzoek, Other research (not in main researchprogram), Spekhorst, Lotte S, van der Rijst, Lisa P, de Graaf, Marlies, van Megen, Maxime, Zuithoff, Nicolaas P A, Knulst, André C, de Bruin-Weller, Marjolein S, and Le, Thuy-My

Published
2023

37. Effect of a multifaceted antibiotic stewardship intervention to improve antibiotic prescribing for suspected urinary tract infections in frail older adults (ImpresU): pragmatic cluster randomised controlled trial in four European countries

Author

Hartman, Esther A R, primary, van de Pol, Alma C, additional, Heltveit-Olsen, Silje Rebekka, additional, Lindbæk, Morten, additional, Høye, Sigurd, additional, Lithén, Sara Sofia, additional, Sundvall, Pär-Daniel, additional, Sundvall, Sofia, additional, Arnljots, Egill Snaebjörnsson, additional, Gunnarsson, Ronny, additional, Kowalczyk, Anna, additional, Godycki-Cwirko, Maciek, additional, Platteel, Tamara N, additional, Groen, Wim G, additional, Monnier, Annelie A, additional, Zuithoff, Nicolaas P, additional, Verheij, Theo J M, additional, and Hertogh, Cees M P M, additional

Published
2023
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38. Effectiveness of analgesic ear drops as add-on treatment to oral analgesics in children with acute otitis media: study protocol of the OPTIMA pragmatic randomised controlled trial

Author

de Sévaux, Joline L H, primary, Damoiseaux, Roger A M J, additional, Hullegie, Saskia, additional, Sanders, Elisabeth A M, additional, de Wit, G Ardine, additional, Zuithoff, Nicolaas P A, additional, Yardley, Lucy, additional, Anthierens, Sibyl, additional, Little, Paul, additional, Hay, Alastair D, additional, Schilder, Anne G M, additional, and Venekamp, Roderick P, additional

Published
2023
Full Text
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40. The positive effect of dupilumab on comorbid asthma in patients with atopic dermatitis

Author

Spekhorst, Lotte S., primary, de Graaf, Marlies, additional, van der Rijst, Lisa P., additional, Zuithoff, Nicolaas P. A., additional, Schweizer, René C., additional, Kamsteeg, Marijke, additional, Haeck, Inge, additional, van Lynden‐van Nes, Anneke M. T., additional, van Lumig, Paula, additional, Romeijn, Geertruida L. E., additional, Schuttelaar, Marie‐Louise, additional, and de Bruin‐Weller, Marjolein S., additional

Published
2023
Full Text
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42. Association of Serum Dupilumab Levels at 16 Weeks With Treatment Response and Adverse Effects in Patients With Atopic Dermatitis

Author

Spekhorst, Lotte S., primary, de Graaf, Marlies, additional, Loeff, Floris, additional, Zuithoff, Nicolaas P. A., additional, Bakker, Daphne, additional, Boesjes, Celeste M., additional, Thijs, Judith, additional, Achten, Roselie, additional, van Wijk, Femke, additional, Rispens, Theo, additional, and de Bruin-Weller, Marjolein S., additional

Published
2022
Full Text
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43. Dupilumab in daily practice for the treatment of pediatric atopic dermatitis: 28‐week clinical and biomarker results from the BioDay registry

Author

Kamphuis, Esmé, primary, Boesjes, Celeste M., additional, Loman, Laura, additional, Bakker, Daphne S., additional, Poelhekken, Mila, additional, Zuithoff, Nicolaas P. A., additional, Kamsteeg, Marijke, additional, Romeijn, Geertruida L. E., additional, van Wijk, Femke, additional, de Bruin‐Weller, Marjolein S., additional, de Graaf, Marlies, additional, and Schuttelaar, Marie L. A., additional

Published
2022
Full Text
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45. Patient Preferences for Disposable and Reusable Vaginal Specula and Their Willingness to Compromise in the Era of Climate Change: A Cross-Sectional Study

Author

Ten Buuren, Amber A.A., Poolman, Tessa B., Bullens, Lauren M., Van Hanegem, Nehalennia, Bongers, Marlies Y., Klerkx, Wenche M., Timmermans, Anne, Zuithoff, Nicolaas P.A., and Kwee, Anneke

Abstract

(Abstracted from BJOG. 2024;131:684–689The World Health Organization emphasizes that the climate crisis is the single biggest health threat facing humanity, and more than 200 medical journals have called on world leaders to take more and faster action against climate change. Despite this, hospitals have increasingly relied on disposable instruments such as plastic specula, which are incinerated after a single use.

Published
2024
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46. Dupilumab Drug Survival and Associated Predictors in Patients With Moderate to Severe Atopic Dermatitis

Author

Spekhorst, Lotte S., primary, de Graaf, Marlies, additional, Zuithoff, Nicolaas P. A., additional, van den Reek, Juul M. P. A., additional, Kamsteeg, Marijke, additional, Boesjes, Celeste M., additional, Romeijn, Geertruida L. E., additional, Loman, Laura, additional, Haeck, Inge, additional, Oosting, Albert J., additional, de Boer-Brand, Astrid, additional, Touwslager, Wouter R. H., additional, Flinterman, Annebeth, additional, van Lynden-van Nes, Anneke M. T., additional, Gostynski, Antoni H., additional, de Bruin-Weller, Marjolein S., additional, and Schuttelaar, Marie-Louise, additional

Published
2022
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