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1. Hazelnut allergy across Europe dissected molecularly: A EuroPrevall outpatient clinic survey

Author

Datema, Mareen R., Zuidmeer-Jongejan, Laurian, Asero, Riccardo, Barreales, Laura, Belohlavkova, Simona, de Blay, Frédéric, Bures, Peter, Clausen, Michael, Dubakiene, Ruta, Gislason, David, Jedrzejczak-Czechowicz, Monika, Kowalski, Marek L., Knulst, André C., Kralimarkova, Tanya, Le, Thuy-My, Lovegrove, Alison, Marsh, Justin, Papadopoulos, Nikolaos G., Popov, Todor, del Prado, Náyade, Purohit, Ashok, Reese, Gerald, Reig, Isabel, Seneviratne, Suranjith L., Sinaniotis, Athanasios, Versteeg, Serge A., Vieths, Stefan, Zwinderman, Aeilko H., Mills, Clare, Lidholm, Jonas, Hoffmann-Sommergruber, Karin, Fernández-Rivas, Montserrat, Ballmer-Weber, Barbara, and van Ree, Ronald

Published
2015
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3. List of Contributors

Author

Alldrick, Anton, primary, Asero, Ricardo, additional, Ballmer-Weber, Barbara K., additional, Baranowsky, Susan A., additional, Baumert, Joseph L., additional, Botjes, Erna, additional, Burney, Peter, additional, Cochrane, Stella, additional, Crevel, René W.R., additional, Critenden, Ross, additional, Dubois, Anthony E.J., additional, Dunaif, George E., additional, DunnGalvin, Audrey, additional, Fernández-Rivas, Montserrat, additional, Flokstra-de Blok, B.M.J., additional, Gendel, Steven M., additional, Grabenhenrich, Linus, additional, Grinter, Kirsten, additional, Hattersley, Sue, additional, Houben, Geert, additional, Husby, Steffen, additional, Ivarsson, Anneli, additional, Johnson, Phil E., additional, Keil, Thomas, additional, King, Rita, additional, Knulst, André C., additional, Leitch, I.S., additional, Madsen, Charlotte Bernhard, additional, McIntosh, J., additional, Mills, Clare, additional, Nørhede, Pia, additional, O’B. Hourihane, Jonathan, additional, Olsson, Cecilia, additional, Pfaff, Sylvia, additional, Reading, David, additional, Remington, Ben C., additional, Sherlock, Robin, additional, Skrypec, Dan, additional, Taylor, Steven L., additional, van Ravenhorst, Marjan, additional, Wal, Jean-Michel, additional, Ward, Rachel, additional, Wong, Gary, additional, and Zuidmeer-Jongejan, Laurian, additional

Published
2014
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4. Sensitization to Cor a 9 and Cor a 14 is highly specific for a hazelnut allergy with objective symptoms in Dutch children and adults

Author

Masthoff, Laury J.N., Mattsson, Lars, Zuidmeer-Jongejan, Laurian, Lidholm, Jonas, Andersson, Kerstin, Akkerdaas, Jaap H., Versteeg, Serge A., Garino, Cristiano, Meijer, Yolanda, Kentie, Petra, Versluis, Astrid, den Hartog Jager, Constance F., Bruijnzeel-Koomen, Carla A.F.M., Knulst, André C., van Ree, Ronald, van Hoffen, Els, and Pasmans, Suzanne G.M.A.

Published
2013
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5. Boiling peanut Ara h 1 results in the formation of aggregates with reduced allergenicity

Author

Blanc, Fany, Vissers, Yvonne M., Adel-Patient, Karine, Rigby, Neil M., Mackie, Alan R., Gunning, Patrick A., Wellner, Nikolaus K., Skov, Per S., Przybylski-Nicaise, Laetitia, Ballmer-Weber, Barbara, Zuidmeer-Jongejan, Laurian, Szépfalusi, Zsolt, Ruinemans-Koerts, Janneke, Jansen, Ad P. H., Bernard, Hervé, Wal, Jean-Michel, Savelkoul, Huub F. J., Wichers, Harry J., and Mills, Clare E. N.

Published
2011
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6. FAST: towards safe and effective subcutaneous immunotherapy of persistent life-threatening food allergies

Author

Zuidmeer-Jongejan Laurian, Fernandez-Rivas Montserrat, Poulsen Lars K, Neubauer Angela, Asturias Juan, Blom Lars, Boye Joyce, Bindslev-Jensen Carsten, Clausen Michael, Ferrara Rosa, Garosi Paula, Huber Hans, Jensen Bettina M, Koppelman Stef, Kowalski Marek L, Lewandowska-Polak Anna, Linhart Birgit, Maillere Bernard, Mari Adriano, Martinez Alberto, Mills Clare EN, Nicoletti Claudio, Opstelten Dirk-Jan, Papadopoulos Nikos G, Portoles Antonio, Rigby Neil, Scala Enrico, Schnoor Heidi J, Sigurdardottir Sigurveig T, Stavroulakis George, Stolz Frank, Swoboda Ines, Valenta Rudolf, van den Hout Rob, Versteeg Serge A, Witten Marianne, and van Ree Ronald

Subjects
FAST, Food allergy, Specific immunotherapy, Subcutaneous, Sublingual, Fish, Peach, Hypoallergens, Immunologic diseases. Allergy, RC581-607
Abstract

Abstract The FAST project (Food Allergy Specific Immunotherapy) aims at the development of safe and effective treatment of food allergies, targeting prevalent, persistent and severe allergy to fish and peach. Classical allergen-specific immunotherapy (SIT), using subcutaneous injections with aqueous food extracts may be effective but has proven to be accompanied by too many anaphylactic side-effects. FAST aims to develop a safe alternative by replacing food extracts with hypoallergenic recombinant major allergens as the active ingredients of SIT. Both severe fish and peach allergy are caused by a single major allergen, parvalbumin (Cyp c 1) and lipid transfer protein (Pru p 3), respectively. Two approaches are being evaluated for achieving hypoallergenicity, i.e. site-directed mutagenesis and chemical modification. The most promising hypoallergens will be produced under GMP conditions. After pre-clinical testing (toxicology testing and efficacy in mouse models), SCIT with alum-absorbed hypoallergens will be evaluated in phase I/IIa and IIb randomized double-blind placebo-controlled (DBPC) clinical trials, with the DBPC food challenge as primary read-out. To understand the underlying immune mechanisms in depth serological and cellular immune analyses will be performed, allowing identification of novel biomarkers for monitoring treatment efficacy. FAST aims at improving the quality of life of food allergic patients by providing a safe and effective treatment that will significantly lower their threshold for fish or peach intake, thereby decreasing their anxiety and dependence on rescue medication.

Published
2012
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8. International Archives of Allergy and Immunology / Development of a hypoallergenic recombinant parvalbumin for first-in-man subcutaneous immunotherapy of fish allergy

Author

Zuidmeer-Jongejan, Laurian, Huber, H, Swoboda, Ines, Rigby, N, Versteeg, SA, Jensen, BM, Quaak, S, Akkerdaas, JH, Blom, L, Asturias, J, Bindslev-Jensen, C, Bernardi, ML, Clausen, M, Ferrara, R, Hauer, M, Heyse, J, Kopp, S, Kowalski, ML, Lewandowska-Polak, A, Linhart, B, Maderegger, B, Maillere, B, Mari, A, Martinez, A, Mills, EN, Neubauer, A, Nicoletti, C, Papadopoulos, NG, Portoles, A, Ranta-Panula, V, Santos-Magadan, S, Schnoor, HJ, Sigurdardottir, ST, Stahl-Skov, P, Stavroulakis, G, Stegfellner, G, Vázquez-Cortés, S, Witten, M, Stolz, F, Poulsen, LK, Fernandez-Rivas, M, Valenta, Rudolf, and van Ree, R

Published
2015
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9. Clinical and Translational Allergy / Oil body-associated hazelnut allergens including oleosins are underrepresented in diagnostic extracts but associated with severe symptoms

Author

Zuidmeer-Jongejan, Laurian, Fernández-Rivas, Montserrat, Winter, Marcel GT, Akkerdaas, Jaap H, Summers, Colin, Lebens, Ans, Knulst, André C, Schilte, Piet, Briza, Peter, Gadermaier, Gabriele, and van Ree, Ronald

Subjects
Food_allergy, Oil_bodies, Oleosins_Hazelnut, IgE-mediated
Abstract

BACKGROUND: Oil body-associated allergens such as oleosins have been reported for important allergenic foods such as peanut, sesame and hazelnut. Here we investigate whether oil body associated proteins (OAPs) are linked with specific clinical phenotypes and whether they are represented in skin prick test (SPT) reagents. METHODS: A hazelnut OAP fraction was characterized by mass-spectrometry (MS) to identify its major constituents. Polyclonal rabbit antibodies were generated against hazelnut OAPs. The presence of OAPs in commercially available hazelnut SPTs was studied by immunoblot and spiking experiments. OAP-specific IgE antibodies were measured in sera from patients with a convincing history of hazelnut allergy by RAST (n = 91), immunoblot (n = 22) and basophil histamine release (BHR; n = 14). RESULTS: Hazelnut OAPs were analysed by MS and found to be dominated by oleosins at 14 and 17 kDa, and a 27 kDa band containing oleosin dimers and unidentified protein. In 36/91 sera specific IgE against hazelnut OAPs was detected, and confirmed to be biologically active by BHR (n = 14). The majority (21/22) recognized the oleosin bands at 17 kDa on immunoblot, of which 11 exclusively. These OAP-specific IgE responses dominated by oleosin were associated with systemic reactions to hazelnut (OR 4.24; p = 0.015) and negative SPT (2 6.3, p = 0.012). Immunoblot analysis using OAP-specific rabbit antiserum demonstrated that commercial SPT reagents are virtually devoid of OAPs, sometimes (3/9) resulting in false-negative SPT. Spiking of SPT reagents with OAP restored serum IgE binding of these false-negative patients on immunoblot at mainly 17 kDa. CONCLUSION: Hazelnut allergens found in oil bodies dominated by oleosin are associated with more severe systemic reactions and negative SPT. Defatted diagnostic extracts are virtually devoid of these allergens, resulting in poor sensitivity for detection of IgE antibodies against these clinically relevant molecules.

Published
2014
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10. Effect of Processing on the Allergenicity of Foods

Author

Mills, Clare, Johnson, Phil E., Zuidmeer-Jongejan, Laurian, Critenden, Ross, Wal, Jean-Michel, Asero, Riccardo, Madsen, Charlotte, Crevel, René, Taylor, Steve, Amsterdam institute for Infection and Immunity, and Experimental Immunology

Subjects
Allergic reaction, business.industry, Chemistry, digestive, oral, and skin physiology, medicine.disease_cause, Animal origin, Allergen, medicine.anatomical_structure, Immunology, medicine, Food processing, Food allergens, business, Sensitization
Abstract

Proteins involved in sensitizing or eliciting allergic reactions may have undergone extensive modification during food processing and be present within complex structures within food. These physicochemical changes will alter the way in which proteins are broken down during digestion and may modify the form in which they are taken up across the gut mucosal barrier and presented to the immune system. Data on how processing might affect sensitization to food are currently sparse. However, much more data are available, which are beginning to give insights into how food processing may affect elicitation of allergic reactions, particularly in affecting the binding of IgE, which lies at the heart of triggering an allergic reaction. The chapter summarizes current knowledge of the effects of processing on the major food allergens of plant and animal origin as well as the effects of processing of whole foods.

Published
2014
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11. Hazelnut allergy across Europe dissected molecularly: A EuroPrevall outpatient clinic survey

Author

Infection & Immunity, MS Dermatologie/Allergologie, Datema, Mareen R., Zuidmeer-Jongejan, Laurian, Asero, Riccardo, Barreales, Laura, Belohlavkova, Simona, de Blay, Frederic, Bures, Peter, Clausen, Michael, Dubakiene, Ruta, Gislason, David, Jedrzejczak-Czechowicz, Monika, Kowalski, Marek L., Knulst, Andre C., Kralimarkova, Tanya, Le, Thuy-My, Lovegrove, Alison, Marsh, Justin, Papadopoulos, Nikolaos G., Popov, Todor, del Prado, Nayade, Purohit, Ashok, Reese, Gerald, Reig, Isabel, Seneviratne, Suranjith L., Sinaniotis, Athanasios, Versteeg, Serge A., Vieths, Stefan, Zwinderman, Aeilko H., Mills, Clare, Lidholm, Jonas, Hoffmann-Sommergruber, Karin, Fernandez-Rivas, Montserrat, Ballmer-Weber, Barbara, van Ree, Ronald, Infection & Immunity, MS Dermatologie/Allergologie, Datema, Mareen R., Zuidmeer-Jongejan, Laurian, Asero, Riccardo, Barreales, Laura, Belohlavkova, Simona, de Blay, Frederic, Bures, Peter, Clausen, Michael, Dubakiene, Ruta, Gislason, David, Jedrzejczak-Czechowicz, Monika, Kowalski, Marek L., Knulst, Andre C., Kralimarkova, Tanya, Le, Thuy-My, Lovegrove, Alison, Marsh, Justin, Papadopoulos, Nikolaos G., Popov, Todor, del Prado, Nayade, Purohit, Ashok, Reese, Gerald, Reig, Isabel, Seneviratne, Suranjith L., Sinaniotis, Athanasios, Versteeg, Serge A., Vieths, Stefan, Zwinderman, Aeilko H., Mills, Clare, Lidholm, Jonas, Hoffmann-Sommergruber, Karin, Fernandez-Rivas, Montserrat, Ballmer-Weber, Barbara, and van Ree, Ronald

Published
2015

12. Development of a Hypoallergenic Recombinant Parvalbumin for First-in-Man Subcutaneous Immunotherapy of Fish Allergy

Author

Zuidmeer-Jongejan, Laurian, Huber, Hans, Swoboda, Ines, Rigby, Neil, Versteeg, Serge A, Jensen, Bettina Margrethe, Quaak, Suzanne, Akkerdaas, Jaap H, Blom, L., Asturias, Juan, Bindslev-Jensen, Carsten, Bernardi, Maria L, Clausen, Michael, Ferrara, Rosa, Hauer, Martina, Heyse, Jet, Kopp, Stephan, Kowalski, Marek L, Lewandowska-Polak, Anna, Linhart, Birgit, Maderegger, Bernhard, Maillere, Bernard, Mari, Adriano, Martinez, Alberto, Mills, E N Clare, Neubauer, Angela, Nicoletti, Claudio, Papadopoulos, Nikolaos G, Portoles, Antonio, Ranta-Panula, Ville, Santos-Magadan, Sara, Schnoor, H J, Sigurdardottir, Sigurveig T, Stahl Skov, P, Stavroulakis, George, Stegfellner, Georg, Vázquez-Cortés, Sonia, Witten, M, Stolz, Frank, Poulsen, Lars K., Fernandez-Rivas, Montserrat, Valenta, Rudolf, van Ree, Ronald, Zuidmeer-Jongejan, Laurian, Huber, Hans, Swoboda, Ines, Rigby, Neil, Versteeg, Serge A, Jensen, Bettina Margrethe, Quaak, Suzanne, Akkerdaas, Jaap H, Blom, L., Asturias, Juan, Bindslev-Jensen, Carsten, Bernardi, Maria L, Clausen, Michael, Ferrara, Rosa, Hauer, Martina, Heyse, Jet, Kopp, Stephan, Kowalski, Marek L, Lewandowska-Polak, Anna, Linhart, Birgit, Maderegger, Bernhard, Maillere, Bernard, Mari, Adriano, Martinez, Alberto, Mills, E N Clare, Neubauer, Angela, Nicoletti, Claudio, Papadopoulos, Nikolaos G, Portoles, Antonio, Ranta-Panula, Ville, Santos-Magadan, Sara, Schnoor, H J, Sigurdardottir, Sigurveig T, Stahl Skov, P, Stavroulakis, George, Stegfellner, Georg, Vázquez-Cortés, Sonia, Witten, M, Stolz, Frank, Poulsen, Lars K., Fernandez-Rivas, Montserrat, Valenta, Rudolf, and van Ree, Ronald

Abstract

BACKGROUND: The FAST (food allergy-specific immunotherapy) project aims at developing safe and effective subcutaneous immunotherapy for fish allergy, using recombinant hypoallergenic carp parvalbumin, Cyp c 1.OBJECTIVES: Preclinical characterization and good manufacturing practice (GMP) production of mutant Cyp (mCyp) c 1.METHODS: Escherichia coli-produced mCyp c 1 was purified using standard chromatographic techniques. Physicochemical properties were investigated by gel electrophoresis, size exclusion chromatography, circular dichroism spectroscopy, reverse-phase high-performance liquid chromatography and mass spectrometry. Allergenicity was assessed by ImmunoCAP inhibition and basophil histamine release assay, immunogenicity by immunization of laboratory animals and stimulation of patients' peripheral blood mononuclear cells (PBMCs). Reference molecules were purified wild-type Cyp c 1 (natural and/or recombinant). GMP-compliant alum-adsorbed mCyp c 1 was tested for acute toxicity in mice and rabbits and for repeated-dose toxicity in mice. Accelerated and real-time protocols were used to evaluate stability of mCyp c 1 as drug substance and drug product.RESULTS: Purified mCyp c 1 behaves as a folded and stable molecule. Using sera of 26 double-blind placebo-controlled food-challenge-proven fish-allergic patients, reduction in allergenic activity ranged from 10- to 5,000-fold (1,000-fold on average), but with retained immunogenicity (immunization in mice/rabbits) and potency to stimulate human PBMCs. Toxicity studies revealed no toxic effects and real-time stability studies on the Al(OH)3-adsorbed drug product demonstrated at least 20 months of stability.CONCLUSION: The GMP drug product developed for treatment of fish allergy has the characteristics targeted for in FAST: i.e. hypoallergenicity with retained immunogenicity. These results have warranted first-in-man immunotherapy studies to evaluate the safety of this innovative vaccine.

Published
2015

13. Clinical and translational allergy / FAST: Towards safe and effective subcutaneous immunotherapy of persistent life-threatening food allergies

Author

Zuidmeer-Jongejan, Laurian, Fernandez-Rivas, M., Poulsen, L. K., Neubauer, A., Asturias, J., Blom, L., Boye, J., Bindslev-Jensen, C., Clausen, M., Ferrara, R., Garosi, P., Huber, H., Jensen, B. M., Koppelman, S., Kowalski, M. L., Lewandowska-Polak, A., Linhart, B., Maillere, B., Mari, A., Martinez, A., Mills, C. E., Nicoletti, C., Opstelten, D. J., Papadopoulos, N. G., Portoles, A., Rigby, N., Scala, E., Schnoor, H. J., Sigursdottir, S., Stavroulakis, G., Stolz, F., Swoboda, Ines, Valenta, R., van den Hout, R., Versteeg, S. A., Witten, M., and van Ree, R.

Published
2012
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14. Development of a Hypoallergenic Recombinant Parvalbumin for First-in-Man Subcutaneous Immunotherapy of Fish Allergy

Author

Zuidmeer-Jongejan, Laurian, primary, Huber, Hans, additional, Swoboda, Ines, additional, Rigby, Neil, additional, Versteeg, Serge A., additional, Jensen, Bettina M., additional, Quaak, Suzanne, additional, Akkerdaas, Jaap H., additional, Blom, Lars, additional, Asturias, Juan, additional, Bindslev-Jensen, Carsten, additional, Bernardi, Maria L., additional, Clausen, Michael, additional, Ferrara, Rosa, additional, Hauer, Martina, additional, Heyse, Jet, additional, Kopp, Stephan, additional, Kowalski, Marek L., additional, Lewandowska-Polak, Anna, additional, Linhart, Birgit, additional, Maderegger, Bernhard, additional, Maillere, Bernard, additional, Mari, Adriano, additional, Martinez, Alberto, additional, Mills, E.N. Clare, additional, Neubauer, Angela, additional, Nicoletti, Claudio, additional, Papadopoulos, Nikolaos G., additional, Portoles, Antonio, additional, Ranta-Panula, Ville, additional, Santos-Magadan, Sara, additional, Schnoor, Heidi J., additional, Sigurdardottir, Sigurveig T., additional, Stahl-Skov, Per, additional, Stavroulakis, George, additional, Stegfellner, Georg, additional, Vázquez-Cortés, Sonia, additional, Witten, Marianne, additional, Stolz, Frank, additional, Poulsen, Lars K., additional, Fernandez-Rivas, Montserrat, additional, Valenta, Rudolf, additional, and van Ree, Ronald, additional

Published
2015
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16. Oil body‐associated hazelnut allergens including oleosins are underrepresented in diagnostic extracts but associated with severe symptoms

Author

Zuidmeer‐Jongejan, Laurian, primary, Fernández‐Rivas, Montserrat, additional, Winter, Marcel GT, additional, Akkerdaas, Jaap H, additional, Summers, Colin, additional, Lebens, Ans, additional, Knulst, André C, additional, Schilte, Piet, additional, Briza, Peter, additional, Gadermaier, Gabriele, additional, and Ree, Ronald, additional

Published
2014
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17. FAST:Towards safe and effective subcutaneous immunotherapy of persistent life-threatening food allergies

Author

Zuidmeer-Jongejan, Laurian, Fernandez-Rivas, Montserrat, Poulsen, Lars K., Neubauer, Angela, Asturias, Juan, Blom, Lars, Boye, Joyce, Bindslev-Jensen, Carsten, Clausen, Michael Stellian, Ferrara, Rosa, Garosi, Paula, Huber, Hans, Jensen, Bettina M, Koppelman, Stef, Kowalski, Marek L, Lewandowska-Polak, Anna, Linhart, Birgit, Maillere, Bernard, Mari, Adriano, Martinez, Alberto, Mills, Clare En, Nicoletti, Claudio, Opstelten, Dirk-Jan, Papadopoulos, Nikos G, Portoles, Antonio, Rigby, Neil, Scala, Enrico, Schnoor, Heidi J, Sigursdottir, Sigurveig, Stavroulakis, Georg, Stolz, Frank, Swoboda, Ines, Valenta, Rudolf, van den Hout, Rob, Versteeg, Serge A, Witten, Marianne, van Ree, Ronald, Zuidmeer-Jongejan, Laurian, Fernandez-Rivas, Montserrat, Poulsen, Lars K., Neubauer, Angela, Asturias, Juan, Blom, Lars, Boye, Joyce, Bindslev-Jensen, Carsten, Clausen, Michael Stellian, Ferrara, Rosa, Garosi, Paula, Huber, Hans, Jensen, Bettina M, Koppelman, Stef, Kowalski, Marek L, Lewandowska-Polak, Anna, Linhart, Birgit, Maillere, Bernard, Mari, Adriano, Martinez, Alberto, Mills, Clare En, Nicoletti, Claudio, Opstelten, Dirk-Jan, Papadopoulos, Nikos G, Portoles, Antonio, Rigby, Neil, Scala, Enrico, Schnoor, Heidi J, Sigursdottir, Sigurveig, Stavroulakis, Georg, Stolz, Frank, Swoboda, Ines, Valenta, Rudolf, van den Hout, Rob, Versteeg, Serge A, Witten, Marianne, and van Ree, Ronald

Abstract

The FAST project (Food Allergy Specific Immunotherapy) aims at the development of safe and effective treatment of food allergies, targeting prevalent, persistent and severe allergy to fish and peach. Classical allergen-specific immunotherapy (SIT), using subcutaneous injections with aqueous food extracts may be effective but has proven to be accompanied by too many anaphylactic side-effects. FAST aims to develop a safe alternative by replacing food extracts with hypoallergenic recombinant major allergens as the active ingredients of SIT. Both severe fish and peach allergy are caused by a single major allergen, parvalbumin (Cyp c 1) and lipid transfer protein (Pru p 3), respectively. Two approaches are being evaluated for achieving hypoallergenicity, i.e. site-directed mutagenesis and chemical modification. The most promising hypoallergens will be produced under GMP conditions. After pre-clinical testing (toxicology testing and efficacy in mouse models), SCIT with alum-absorbed hypoallergens will be evaluated in phase I/IIa and IIb randomized double-blind placebo-controlled (DBPC) clinical trials, with the DBPC food challenge as primary read-out. To understand the underlying immune mechanisms in depth serological and cellular immune analyses will be performed, allowing identification of novel biomarkers for monitoring treatment efficacy. FAST aims at improving the quality of life of food allergic patients by providing a safe and effective treatment that will significantly lower their threshold for fish or peach intake, thereby decreasing their anxiety and dependence on rescue medication.

Published
2012

18. Oral Delivery of a Probiotic Induced Changes at the Nasal Mucosa of Seasonal Allergic Rhinitis Subjects after Local Allergen Challenge: A Randomised Clinical Trial

Author

Ivory, Kamal, primary, Wilson, Andrew M., additional, Sankaran, Prasanna, additional, Westwood, Marta, additional, McCarville, Justin, additional, Brockwell, Claire, additional, Clark, Allan, additional, Dainty, Jack R., additional, Zuidmeer-Jongejan, Laurian, additional, and Nicoletti, Claudio, additional

Published
2013
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19. 72 The Choice of Hypoallergens for Fish and Peach to Develop Food Allergy Specific Immunotherapy (TheFAST Project)

Author

Zuidmeer-Jongejan, Laurian, primary, Versteeg, Serge, additional, Poulsen, Lars, additional, Fernandez-Rivas, Montserrat, additional, Kowalski, Marek L., additional, Papadopoulos, Nikos, additional, Mari, Adriano, additional, Swoboda, Ines, additional, Clausen, Michael, additional, Bindslev-Jensen, Carsten, additional, Neubauer, Angela, additional, Koppelman, Stef, additional, Mills, Clare, additional, Asturias, Juan A., additional, and van Ree, Ronald, additional

Published
2012
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20. Sensitization Prevalence, Antibody Cross-Reactivity and Immunogenic Peptide Profile of Api g 2, the Non-Specific Lipid Transfer Protein 1 of Celery

Author

Gadermaier, Gabriele, primary, Hauser, Michael, additional, Egger, Matthias, additional, Ferrara, Rosetta, additional, Briza, Peter, additional, Souza Santos, Keity, additional, Zennaro, Danila, additional, Girbl, Tamara, additional, Zuidmeer-Jongejan, Laurian, additional, Mari, Adriano, additional, and Ferreira, Fatima, additional

Published
2011
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21. Effect of Heating and Glycation on the Allergenicity of 2S Albumins (Ara h 2/6) from Peanut

Author

Vissers, Yvonne M., primary, Blanc, Fany, additional, Skov, Per Stahl, additional, Johnson, Phil E., additional, Rigby, Neil M., additional, Przybylski-Nicaise, Laetitia, additional, Bernard, Hervé, additional, Wal, Jean-Michel, additional, Ballmer-Weber, Barbara, additional, Zuidmeer-Jongejan, Laurian, additional, Szépfalusi, Zsolt, additional, Ruinemans-Koerts, Janneke, additional, Jansen, Ad P. H., additional, Savelkoul, Huub F. J., additional, Wichers, Harry J., additional, Mackie, Alan R., additional, Mills, Clare E. N., additional, and Adel-Patient, Karine, additional

Published
2011
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