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4. Global patterns of care in advanced stage mycosis fungoides/Sezary syndrome: a multicenter retrospective follow-up study from the Cutaneous Lymphoma International Consortium

Author

Quaglino, P., Maule, M., Prince, H.M., Porcu, P., Horwitz, S., Duvic, M., Talpur, R., Vermeer, M., Bagot, M., Guitart, J., Papadavid, E., Sanches, J.A., Hodak, E., Sugaya, M., Berti, E., Ortiz-Romero, P., Pimpinelli, N., Servitje, O., Pileri, A., Zinzani, P.L., Estrach, T., Knobler, R., Stadler, R., Fierro, M.T., Alberti Violetti, S., Amitay-Laish, I., Antoniou, C., Astrua, C., Chaganti, S., Child, F., Combalia, A., Fabbro, S., Fava, P., Grandi, V., Jonak, C., Martinez-Escala, E., Kheterpal, M., Kim, E.J., McCormack, C., Miyagaki, T., Miyashiro, D., Morris, S., Muniesa, C., Nikolaou, V., Ognibene, G., Onida, F., Osella-Abate, S., Porkert, S., Postigo-Llorente, C., Ram-Wolff, C., Ribero, S., Rogers, K., Sanlorenzo, M., Stranzenbach, R., Spaccarelli, N., Stevens, A., Zugna, D., Rook, A.H., Geskin, L.J., Willemze, R., Whittaker, S., Hoppe, R., Scarisbrick, J., and Kim, Y.

Published
2017
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6. Association Study between Polymorphisms in DNA Methylation-Related Genes and Testicular Germ Cell Tumor Risk

Author

Grasso, C., Popovic, M., Isaevska, E., Lazzarato, F., Fiano, V., Zugna, D., Pluta, J., Weathers, B., D'Andrea, K., Almstrup, K., Anson-Cartwright, L., Bishop, D.T., Chanock, S.J., Chen, C, Cortessis, V.K., Dalgaard, M.D., Daneshmand, S., Ferlin, A., Foresta, C., Frone, M.N., Gamulin, M., Gietema, J.A., Greene, M.H., Grotmol, T., Hamilton, R.J., Haugen, T.B., Hauser, R., Karlsson, R., Kiemeney, L.A.L.M., Lessel, D., Lista, P., Lothe, R.A., Loveday, C., Meijer, C., Nead, K.T., Nsengimana, J., Skotheim, R.I., Turnbull, C., Vaughn, D.J., Wiklund, F., Zheng, T., Zitella, A., Schwartz, S.M., McGlynn, K.A., Kanetsky, P.A., Nathanson, K.L., Richiardi, L., Grasso, C., Popovic, M., Isaevska, E., Lazzarato, F., Fiano, V., Zugna, D., Pluta, J., Weathers, B., D'Andrea, K., Almstrup, K., Anson-Cartwright, L., Bishop, D.T., Chanock, S.J., Chen, C, Cortessis, V.K., Dalgaard, M.D., Daneshmand, S., Ferlin, A., Foresta, C., Frone, M.N., Gamulin, M., Gietema, J.A., Greene, M.H., Grotmol, T., Hamilton, R.J., Haugen, T.B., Hauser, R., Karlsson, R., Kiemeney, L.A.L.M., Lessel, D., Lista, P., Lothe, R.A., Loveday, C., Meijer, C., Nead, K.T., Nsengimana, J., Skotheim, R.I., Turnbull, C., Vaughn, D.J., Wiklund, F., Zheng, T., Zitella, A., Schwartz, S.M., McGlynn, K.A., Kanetsky, P.A., Nathanson, K.L., and Richiardi, L.

Abstract

Item does not contain fulltext, BACKGROUND: Testicular germ cell tumors (TGCT), histologically classified as seminomas and nonseminomas, are believed to arise from primordial gonocytes, with the maturation process blocked when they are subjected to DNA methylation reprogramming. SNPs in DNA methylation machinery and folate-dependent one-carbon metabolism genes have been postulated to influence the proper establishment of DNA methylation. METHODS: In this pathway-focused investigation, we evaluated the association between 273 selected tag SNPs from 28 DNA methylation-related genes and TGCT risk. We carried out association analysis at individual SNP and gene-based level using summary statistics from the Genome Wide Association Study meta-analysis recently conducted by the international Testicular Cancer Consortium on 10,156 TGCT cases and 179,683 controls. RESULTS: In individual SNP analyses, seven SNPs, four mapping within MTHFR, were associated with TGCT risk after correction for multiple testing (q ≤ 0.05). Queries of public databases showed that three of these SNPs were associated with MTHFR changes in enzymatic activity (rs1801133) or expression level in testis tissue (rs12121543, rs1476413). Gene-based analyses revealed MTHFR (q = 8.4 × 10-4), methyl-CpG-binding protein 2 (MECP2; q = 2 × 10-3), and ZBTB4 (q = 0.03) as the top TGCT-associated genes. Stratifying by tumor histology, four MTHFR SNPs were associated with seminoma. In gene-based analysis MTHFR was associated with risk of seminoma (q = 2.8 × 10-4), but not with nonseminomatous tumors (q = 0.22). CONCLUSIONS: Genetic variants within MTHFR, potentially having an impact on the DNA methylation pattern, are associated with TGCT risk. IMPACT: This finding suggests that TGCT pathogenesis could be associated with the folate cycle status, and this relation could be partly due to hereditary factors.

Published
2022

11. Minor Hepatectomies: Focusing a Blurred Picture: Analysis of the Outcome of 4471 Open Resections in Patients Without Cirrhosis

Author

Viganò, L, Torzilli, G, Troisi, R, Aldrighetti, L, Ferrero, A, Majno, P, Toso, C, Figueras, J, Cherqui, D, Adam, R, Kokudo, N, Hasegawa, K, Guglielmi, A, Krawczyk, M, Giuliante, Felice, Hilal, Ma, Costa-Maia, J, Pinna, Ad, Cescon, M, De Santibanes, E, Urbani, L, Pawlik, T, Costa, G, Zugna, D, Clisco, Group., Vigano, L., Torzilli, G., Troisi, R., Aldrighetti, L., Ferrero, A., Majno, P., Toso, C., Figueras, J., Cherqui, D., Adam, R., Kokudo, N., Hasegawa, K., Guglielmi, A., Krawczyk, M., Giuliante, F., Hilal, M. A., Costa-Maia, J., Pinna, A. D., Cescon, M., De Santibanes, E., Urbani, L., Pawlik, T., Costa, G., Zugna, D., Vigano L., Torzilli G., Troisi R., Aldrighetti L., Ferrero A., Majno P., Toso C., Figueras J., Cherqui D., Adam R., Kokudo N., Hasegawa K., Guglielmi A., Krawczyk M., Giuliante F., Hilal M.A., Costa-Maia J., Pinna A.D., Cescon M., De Santibanes E., Urbani L., Pawlik T., Costa G., and Zugna D.

Subjects
Liver surgery, Liver Cirrhosis, Male, Cirrhosis, medicine.medical_treatment, Settore MED/18 - CHIRURGIA GENERALE, Severity of Illness Index, Cohort Studies, 0302 clinical medicine, Postoperative Complications, Laparotomy/methods, Medicine, liver surgery, ddc:617, Liver Cirrhosis/mortality/pathology/surgery, Liver Diseases, Middle Aged, Prognosis, Postoperative Complications/mortality/physiopathology, Treatment Outcome, 030220 oncology & carcinogenesis, classification of hepatectomie, 030211 gastroenterology & hepatology, Female, Adult, Minor Hepatectomies, Hepatectomy/adverse effects/methods, medicine.medical_specialty, classification of hepatectomies, Liver Diseases/mortality/pathology/surgery, 03 medical and health sciences, Severity of illness, overall and severe morbidity, Hepatectomy, Humans, In patient, Aged, Retrospective Studies, Analysis of Variance, Laparotomy, business.industry, Background data, liver failure, minor hepatectomy, Retrospective cohort study, bile leak, medicine.disease, Survival Analysis, Surgery, major hepatectomy, Multicenter study, Multivariate Analysis, parenchyma-sparing surgery, business, Hospitals, High-Volume
Abstract

OBJECTIVE: To elucidate minor hepatectomy (MiH) outcomes. SUMMARY BACKGROUND DATA: Liver surgery has moved toward a parenchyma-sparing approach, favoring MiHs over major resections. MiHs encompass a wide range of procedures. METHODS: We retrospectively evaluated consecutive patients who underwent open liver resections in 17 high-volume centers. EXCLUSION CRITERIA: cirrhosis and associated digestive/biliary resections. Resections were classified as (Brisbane nomenclature): limited resections (LR); (mono)segmentectomies/bisegmentectomies (Segm/Bisegm); right anterior and right posterior sectionectomies (RightAnteriorSect/RightPosteriorSect). Additionally, we defined: complex LRs (ComplexLR = LRs with exposed vessels); postero-superior segmentectomies (PosteroSuperiorSegm = segment (Sg)7, Sg8, and Sg7+Sg8 segmentectomies); and complex core hepatectomies (ComplexCoreHeps = Sg1 segmentectomies and combined resections of Sg4s+Sg8+Sg1). Left lateral sectionectomies (LLSs, n = 442) and right hepatectomies (RHs, n = 1042) were reference standards. Outcomes were adjusted for potential confounders. RESULTS: Four thousand four hundred seventy-one MiHs were analyzed. Compared with RHs, MiHs had lower 90-day mortality (0.5%/2.2%), severe morbidity (8.6%/14.4%), and liver failure rates (2.4%/11.6%, P < 0.001), but similar bile leak rates. LR and LLS had similar outcomes. ComplexLR and Segm/Bisegm of anterolateral segments had higher bile leak rates than LLS rates (OR = 2.35 and OR = 3.24), but similar severe morbidity rates. ComplexCoreHeps had higher bile leak rates than RH rates (OR = 1.94); the severe morbidity rate approached that of RH. PosteroSuperiorSegm, RightAnteriorSect, and RightPosteriorSect had severe morbidity and bile leak rates similar to RH rates. MiHs had low liver failure rates, except RightAnteriorSect (vs LLS OR = 4.02). CONCLUSIONS: MiHs had heterogeneous outcomes. Mortality was low, but MiHs could be stratified according to severe morbidity, bile leak, and liver failure rates. Some MiHs had postoperative outcomes similar to RH.

Published
2019

12. The LifeCycle Project-EU Child Cohort Network: a federated analysis infrastructure and harmonized data of more than 250,000 children and parents

Author

Jaddoe, V.W.V. (Vincent), Felix, J.F. (Janine), Andersen, A-M.N. (Anne-Marie Nybo), Charles, M.A., Chatzi, L. (Leda), Corpeleijn, E. (Eva), Donner, N. (Nina), Elhakeem, A. (Ahmed), Hagen, K. (Knut), Foong, R. (Rachel), Grote, V. (Veit), Haakma, S. (Sido), Hanson, M. (Mark), Harris, J.R. (Jennifer), Heude, B. (Barbara), Huang, R.-C. (Rae-Chi), Inskip, H.M. (Hazel), Järvelin, M.-R. (Marjo-Riitta), Koletzko, B. (Berthold), Lawlor, D.A. (Debbie), Lindeboom, M. (Maarten), McEachan, R.R.C. (Rosemary R. C.), Mikkola, T.M. (Tuija M.), Nader, J.L.T. (Johanna L. T.), de Moira, A.P. (Angela Pinot), Pizzi, C. (Costanza), Richiardi, L. (Lorenzo), Sebert, S. (Sylvain), Schwalber, A. (Ameli), Sunyer, J. (Jordi), Swertz, M.A. (Morris A.), Vafeiadi, M. (Marina), Vrijheid, M. (Martine), Wright, J. (John), Duijts, L. (Liesbeth), El Marroun, H. (Hanan), Gaillard, R. (Romy), Santos, S. (Susana), Geurtsen, M.L. (Madelon L.), Kooijman, M.N. (Marjolein), Mensink-Bout, S.M. (Sara M.), Vehmeijer, F.O.L. (Florianne O.L.), Voerman, E. (Ellis), Nieuwenhuijsen, M. (Mark), Basagaña, X. (Xavier), Bustamante, M. (Mariona), Casas, M. (Miguel), de Castro, M. (Montserrat), Cirugeda, L.E. (Lourdes E.), Fernández-Barrés, S., Fossati, S. (Serena), Garcia, R. (Raquel), Julvez, J. (Jordi), Lertxundi, A. (Aitana), Lertxundi, N. (Nerea), Llop, S. (Sabrina), López-Vicente, M. (Mònica), Lopez-Espinosa, M.-J. (Maria-Jose), Maitre, L. (Lea), Murcia, M. (Mario), Lea, J. (Jose), Urquiza, H. (H.), Warembourg, C. (Charline), Zugna, D. (Daniela), Popovic, M. (Maja), Isaevska, E. (Elena), Maule, M. (Milena), Moccia, C. (Chiara), Moirano, G. (Giovenale), Rasella, D. (Davide), Hanson, M.A. (Mark A.), Inskip, H.M. (Hazel M.), Jacob, C.M. (Chandni Maria), Salika, T. (Theodosia), Cadman, T. (Tim), Strandberg-Larsen, K.M. (Katrine M.), Pedersen, M. (Marie), Vinther, J.L. (Johan L.), Wilson, P. (Paul), Mason, D. (Dan), Yang, T.C. (Tiffany C.), Cardol, M. (Marloes), van Enckevoort, E. (Esther), Hyde, E. (Eleanor), Scholtens, S. (Salome), Snieder, H. (Harold), Thio, C.H.L. (Chris H. L.), Chatzi, L. (Lida), Margetaki, K.C.A. (Katerina C. A.), Roumeliotaki, T. (Theano), Nader, J.L. (Johanna L.), Knudsen, G.P. (Gun Peggy), Magnus, P. (Per), Panico, L. (Lidia), Ichou, M. (Mathieu), de Lauzon-Guillain, B. (Blandine), Dargent-Molina, P. (Patricia), Cornet, M. (Maxime), Florian, S.M. (Sandra M.), Harrar, F. (Faryal), Lepeule, J. (Johanna), Lioret, S., Melchior, M. (Maria), Plancoulaine, S. (Sabine), Männikkö, M. (Minna), Parmar, P. (Priyanka), Rautio, N. (Nina), Ronkainen, J. (Justiina), Tolvanen, M. (Mimmi), Aumüller, N. (Nicole), Closa-Monasterolo, R. (Ricardo), Escribano, J. (Joaquin), Ferré, N. (Natalia), Gruszfeld, D. (Dariusz), Gürlich, K. (Kathrin), Langhendries, J.P. (Jean Paul), Luque, V. (Verónica), Riva, E. (Enrica), Schwarzfischer, P. (Phillipp), Totzauer, M. (Martina), Verduci, E. (Elvira), Xhonneux, A. (Annick), Zaragoza-Jordana, M. (Marta), Schwalber, A. (Amelie), Foong, R.E. (Rachel E.), Hall, G.L. (Graham L.), Lin, A. (Ashleigh), Carson, J. (Jennie), Melton, P. (Phillip), Rauschert, S. (Sebastian), Jaddoe, V.W.V. (Vincent), Felix, J.F. (Janine), Andersen, A-M.N. (Anne-Marie Nybo), Charles, M.A., Chatzi, L. (Leda), Corpeleijn, E. (Eva), Donner, N. (Nina), Elhakeem, A. (Ahmed), Hagen, K. (Knut), Foong, R. (Rachel), Grote, V. (Veit), Haakma, S. (Sido), Hanson, M. (Mark), Harris, J.R. (Jennifer), Heude, B. (Barbara), Huang, R.-C. (Rae-Chi), Inskip, H.M. (Hazel), Järvelin, M.-R. (Marjo-Riitta), Koletzko, B. (Berthold), Lawlor, D.A. (Debbie), Lindeboom, M. (Maarten), McEachan, R.R.C. (Rosemary R. C.), Mikkola, T.M. (Tuija M.), Nader, J.L.T. (Johanna L. T.), de Moira, A.P. (Angela Pinot), Pizzi, C. (Costanza), Richiardi, L. (Lorenzo), Sebert, S. (Sylvain), Schwalber, A. (Ameli), Sunyer, J. (Jordi), Swertz, M.A. (Morris A.), Vafeiadi, M. (Marina), Vrijheid, M. (Martine), Wright, J. (John), Duijts, L. (Liesbeth), El Marroun, H. (Hanan), Gaillard, R. (Romy), Santos, S. (Susana), Geurtsen, M.L. (Madelon L.), Kooijman, M.N. (Marjolein), Mensink-Bout, S.M. (Sara M.), Vehmeijer, F.O.L. (Florianne O.L.), Voerman, E. (Ellis), Nieuwenhuijsen, M. (Mark), Basagaña, X. (Xavier), Bustamante, M. (Mariona), Casas, M. (Miguel), de Castro, M. (Montserrat), Cirugeda, L.E. (Lourdes E.), Fernández-Barrés, S., Fossati, S. (Serena), Garcia, R. (Raquel), Julvez, J. (Jordi), Lertxundi, A. (Aitana), Lertxundi, N. (Nerea), Llop, S. (Sabrina), López-Vicente, M. (Mònica), Lopez-Espinosa, M.-J. (Maria-Jose), Maitre, L. (Lea), Murcia, M. (Mario), Lea, J. (Jose), Urquiza, H. (H.), Warembourg, C. (Charline), Zugna, D. (Daniela), Popovic, M. (Maja), Isaevska, E. (Elena), Maule, M. (Milena), Moccia, C. (Chiara), Moirano, G. (Giovenale), Rasella, D. (Davide), Hanson, M.A. (Mark A.), Inskip, H.M. (Hazel M.), Jacob, C.M. (Chandni Maria), Salika, T. (Theodosia), Cadman, T. (Tim), Strandberg-Larsen, K.M. (Katrine M.), Pedersen, M. (Marie), Vinther, J.L. (Johan L.), Wilson, P. (Paul), Mason, D. (Dan), Yang, T.C. (Tiffany C.), Cardol, M. (Marloes), van Enckevoort, E. (Esther), Hyde, E. (Eleanor), Scholtens, S. (Salome), Snieder, H. (Harold), Thio, C.H.L. (Chris H. L.), Chatzi, L. (Lida), Margetaki, K.C.A. (Katerina C. A.), Roumeliotaki, T. (Theano), Nader, J.L. (Johanna L.), Knudsen, G.P. (Gun Peggy), Magnus, P. (Per), Panico, L. (Lidia), Ichou, M. (Mathieu), de Lauzon-Guillain, B. (Blandine), Dargent-Molina, P. (Patricia), Cornet, M. (Maxime), Florian, S.M. (Sandra M.), Harrar, F. (Faryal), Lepeule, J. (Johanna), Lioret, S., Melchior, M. (Maria), Plancoulaine, S. (Sabine), Männikkö, M. (Minna), Parmar, P. (Priyanka), Rautio, N. (Nina), Ronkainen, J. (Justiina), Tolvanen, M. (Mimmi), Aumüller, N. (Nicole), Closa-Monasterolo, R. (Ricardo), Escribano, J. (Joaquin), Ferré, N. (Natalia), Gruszfeld, D. (Dariusz), Gürlich, K. (Kathrin), Langhendries, J.P. (Jean Paul), Luque, V. (Verónica), Riva, E. (Enrica), Schwarzfischer, P. (Phillipp), Totzauer, M. (Martina), Verduci, E. (Elvira), Xhonneux, A. (Annick), Zaragoza-Jordana, M. (Marta), Schwalber, A. (Amelie), Foong, R.E. (Rachel E.), Hall, G.L. (Graham L.), Lin, A. (Ashleigh), Carson, J. (Jennie), Melton, P. (Phillip), and Rauschert, S. (Sebastian)

Abstract

Early life is an important window of opportunity to improve health across the full lifecycle. An accumulating body of evidence suggests that exposure to adverse stressors during early life leads to developmental adaptations, which subsequently affect disease risk in later life. Also, geographical, socio-economic, and ethnic differences are related to health inequalities from early life onwards. To address these important public health challenges, many European pregnancy and childhood cohorts have been established over the last 30 years. The enormous wealth of data of these cohorts has led to important new biological insights and important impact for health from early life onwards. The impact of these cohorts and their data could be further increased by combining data from different cohorts. Combining data will lead to the possibility of identifying smaller effect estimates, and the opportunity to better identify risk groups and risk factors leading to disease across the lifecycle across countries. Also, it enables research on better causal understanding and modelling of life course health trajectories. The EU Child Cohort Network, established by the Horizon2020-funded LifeCycle Project, brings together nineteen pregnancy and childhood cohorts, together including more than 250,000 children and their parents. A large set of variables has been harmonised and standardized across these cohorts. The harmonized data are kept within each institution and can be accessed by external researchers through a shared federated data analysis platform using the R-based platform

Published
2020
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14. Prognostic utility of the Gleason grading system revisions

Author

Zelic, R., primary, Giunchi, F., additional, Fridfeldt, J., additional, Carlsson, J., additional, Davidsson, S., additional, Lianas, L., additional, Mascia, C., additional, Zugna, D., additional, Molinaro, L., additional, Vincent, P.H., additional, Zanetti, G., additional, Andrén, O., additional, Richiardi, L., additional, Akre, O., additional, Fiorentino, M., additional, and Pettersson, A., additional

Published
2020
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15. Minor hepatectomies: focusing a blurred picture. Analysis of the outcome of 4471 open resections in non-cirrhotic patients

Author

Vigano, L., primary, Torzilli, G., additional, Troisi, R., additional, Aldrighetti, L., additional, Ferrero, A., additional, Majno, P., additional, Toso, C., additional, Figueras, J., additional, Cherqui, D., additional, Adam, R., additional, Kokudo, N., additional, Hasegawa, K., additional, Guglielmi, A., additional, Krawczyk, M., additional, Giuliante, F., additional, Hilal, M Abu, additional, Costa-Maia, J., additional, Pinna, A.D., additional, De Santibanes, E., additional, Urbani, L., additional, Pawlik, T., additional, and Zugna, D., additional

Published
2020
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16. Corrigendum: Global patterns of care in advanced stage mycosis fungoides/Sezary syndrome: A multicenter retrospective follow-up study from the Cutaneous Lymphoma International Consortium (Annals of Oncology (2017) 28 (2517-2525) DOI: 10.1093/annonc/mdx352)

Author

Quaglino, P., Maule, M., Prince, H. M., Porcu, P., Horwitz, S., Duvic, M., Talpur, R., Vermeer, M., Bagot, M., Guitart, J., Papadavid, E., Sanches, J. A., Hodak, E., Sugaya, M., Berti, E., Ortiz-Romero, P., Pimpinelli, N., Servitje, O., Pileri, A., Zinzani, P. L., Estrach, T., Knobler, R., Stadler, R., Fierro, M. T., Alberti Violetti, S., Amitay-Laish, I., Antoniou, C., Astrua, C., Chaganti, S., Child, F., Combalia, A., Fabbro, S., Fava, P., Grandi, V., Jonak, C., Martinez-Escala, E., Kheterpal, M., Kim, E. J., Mccormack, C., Miyagaki, T., Miyashiro, D., Morris, S., Muniesa, C., Nikolaou, V., Ognibene, G., Onida, F., Osella-Abate, S., Porkert, S., Postigo-Llorente, C., Ram-Wolff, C., Ribero, S., Rogers, K., Sanlorenzo, M., Stranzenbach, R., Spaccarelli, N., Stevens, A., Zugna, D., Rook, A. H., Geskin, L. J., Willemze, R., Whittaker, S., Hoppe, R., Scarisbrick, J., and Kim, Y.

Published
2019

17. Corrigendum: Global patterns of care in advanced stage mycosis fungoides/Sezary syndrome: A multicenter retrospective follow-up study from the Cutaneous Lymphoma International Consortium (Annals of Oncology (2017) 28 (2517-2525) DOI: 10.1093/annonc/mdx352)

Author

Quaglino, P. Maule, M. Prince, H.M. Porcu, P. Horwitz, S. Duvic, M. Talpur, R. Vermeer, M. Bagot, M. Guitart, J. Papadavid, E. Sanches, J.A. Hodak, E. Sugaya, M. Berti, E. Ortiz-Romero, P. Pimpinelli, N. Servitje, O. Pileri, A. Zinzani, P.L. Estrach, T. Knobler, R. Stadler, R. Fierro, M.T. Alberti Violetti, S. Amitay-Laish, I. Antoniou, C. Astrua, C. Chaganti, S. Child, F. Combalia, A. Fabbro, S. Fava, P. Grandi, V. Jonak, C. Martinez-Escala, E. Kheterpal, M. Kim, E.J. McCormack, C. Miyagaki, T. Miyashiro, D. Morris, S. Muniesa, C. Nikolaou, V. Ognibene, G. Onida, F. Osella-Abate, S. Porkert, S. Postigo-Llorente, C. Ram-Wolff, C. Ribero, S. Rogers, K. Sanlorenzo, M. Stranzenbach, R. Spaccarelli, N. Stevens, A. Zugna, D. Rook, A.H. Geskin, L.J. Willemze, R. Whittaker, S. Hoppe, R. Scarisbrick, J. Kim, Y.

Abstract

In the original article, the affiliation number 16 for authors E. Berti and S. Alberti Violetti was incorrect. It originally read: 'Dermatologic Clinic, University of Milano, Milano, Italy' and has now been changed to 'Department of Dermatology, Fondazione Cà Granda, IRCCS,OMP, Milano, Italy'. © The Author(s) 2018. Published by Oxford University Press on behalf of the European Society for Medical Oncology. All rights reserved. For permissions, please email: journals.permissions@oup.com.

Published
2019

19. Corrections to “Global patterns of care in advanced stage mycosis fungoides/Sezary syndrome: a multicenter retrospective follow-up study from the Cutaneous Lymphoma International Consortium”

Author

Quaglino, P., primary, Maule, M., additional, Prince, H.M., additional, Porcu, P., additional, Horwitz, S., additional, Duvic, M., additional, Talpur, R., additional, Vermeer, M., additional, Bagot, M., additional, Guitart, J., additional, Papadavid, E., additional, Sanches, J.A., additional, Hodak, E., additional, Sugaya, M., additional, Berti, E., additional, Ortiz-Romero, P., additional, Pimpinelli, N., additional, Servitje, O., additional, Pileri, A., additional, Zinzani, P.L., additional, Estrach, T., additional, Knobler, R., additional, Stadler, R., additional, Fierro, M.T., additional, Alberti Violetti, S., additional, Amitay-Laish, I., additional, Antoniou, C., additional, Astrua, C., additional, Chaganti, S., additional, Child, F., additional, Combalia, A., additional, Fabbro, S., additional, Fava, P., additional, Grandi, V., additional, Jonak, C., additional, Martinez-Escala, E., additional, Kheterpal, M., additional, Kim, E.J., additional, McCormack, C., additional, Miyagaki, T., additional, Miyashiro, D., additional, Morris, S., additional, Muniesa, C., additional, Nikolaou, V., additional, Ognibene, G., additional, Onida, F., additional, Osella-Abate, S., additional, Porkert, S., additional, Postigo-Llorente, C., additional, Ram-Wolff, C., additional, Ribero, S., additional, Rogers, K., additional, Sanlorenzo, M., additional, Stranzenbach, R., additional, Spaccarelli, N., additional, Stevens, A., additional, Zugna, D., additional, Rook, A.H., additional, Geskin, L.J., additional, Willemze, R., additional, Whittaker, S., additional, Hoppe, R., additional, Scarisbrick, J., additional, and Kim, Y., additional

Published
2019
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20. Maternal complications in pregnancy and wheezing in early childhood: a pooled analysis of 14 birth cohorts

Author

Zugna, D., Zugna, D., Galassi, C., Annesi-Maesano, I., Baïz, N., Barros, H., Basterrechea, M., Correia, S., Duijts, L., Esplugues, A., Fantini, M.P., Forastiere, F., Gascon, M., Gori, D., Inskip, H., Larsen, P.S., Mommers, M., Andersen, A.M.N., Penders, J., Petersen, M.S., Pike, K., Porta, D., Sonnenschein-van der Voort, A., Steuerwald, U., Sunyer, J., Torrent, M., Vrijheid, M., Richiardi, L., Rusconi, F., Zugna, D., Zugna, D., Galassi, C., Annesi-Maesano, I., Baïz, N., Barros, H., Basterrechea, M., Correia, S., Duijts, L., Esplugues, A., Fantini, M.P., Forastiere, F., Gascon, M., Gori, D., Inskip, H., Larsen, P.S., Mommers, M., Andersen, A.M.N., Penders, J., Petersen, M.S., Pike, K., Porta, D., Sonnenschein-van der Voort, A., Steuerwald, U., Sunyer, J., Torrent, M., Vrijheid, M., Richiardi, L., and Rusconi, F.

Abstract

BACKGROUND:: Evidence on the effect of maternal complications in pregnancy on wheezing in offspring is still insufficient. METHODS:: A pooled analysis was performed on individual participant data from fourteen European birth cohorts to assess the relationship between several maternal pregnancy complications and wheezing symptoms in the offspring. Exposures of interest included hypertension and preeclampsia, diabetes, as well as pre-pregnancy overweight (body mass index between 25 and 29.9) and obesity (body mass index >/=30) compared with normal weight (body mass index between 18.5 and 24.9). Outcomes included both ever and recurrent wheezing from birth up to 12-24 months of age. Cohort-specific crude and adjusted risk ratios (RR) were calculated using log-binomial regression models and then pooled using a random effects model. RESULTS:: The study included 85 509 subjects. Cohort-specific prevalence of ever wheezing varied from 20.0% to 47.3%, and of recurrent wheezing from 3.0% to 14.3%. Adjusted pooled RR for ever and recurrent wheezing were: 1.02 (95% CI: 0.98-1.06) and 1.20 (95% CI: 0.98-1.47) for hypertensive disorders; 1.09 (95% CI: 1.01-1.18) and 1.23 (95% CI: 1.07-1.43) for preeclampsia; 1.04 (95% CI: 0.97-1.13) and 1.24 (95% CI: 0.86-1.79) for diabetes; 1.08 (95% CI: 1.05-1.11) and 1.19 (95% CI: 1.12-1.26) for overweight; 1.12 (95% CI: 1.08-1.17) and 1.16 (95% CI: 0.97-1.39) for obesity. No heterogeneity was found in RR estimates among the cohorts, except for diabetes and recurrent wheezing (P = 0.027). CONCLUSIONS:: Preeclampsia, maternal pre-pregnancy overweight and obesity are associated with an increase risk of wheezing in the offspring.

Published
2015

24. Lifelong Residential Exposure to Green Space and Attention

Author

Dadvand, P. (Payam), Tischer, C. (Christina), Estarlich, M. (Marisa), Llop, S. (Sabrina), Dalmau-Bueno, A. (Albert), López-Vicente, M. (Mònica), Valentín, A. (Antònia), de Keijzer, C. (Carmen), Fernández-Somoano, A. (Ana), Lertxundi, N. (Nerea), Rodriguez-Dehli, C. (Cristina), Gascon, M. (Mireia), Guxens Junyent, M. (Mònica), Zugna, D. (Daniela), Basagaña, X. (Xavier), Nieuwenhuijsen, M. (Mark), Ibarluzea, J.M. (Jesús), Ballester, F. (Ferran), Sunyer, J. (Jordi), Dadvand, P. (Payam), Tischer, C. (Christina), Estarlich, M. (Marisa), Llop, S. (Sabrina), Dalmau-Bueno, A. (Albert), López-Vicente, M. (Mònica), Valentín, A. (Antònia), de Keijzer, C. (Carmen), Fernández-Somoano, A. (Ana), Lertxundi, N. (Nerea), Rodriguez-Dehli, C. (Cristina), Gascon, M. (Mireia), Guxens Junyent, M. (Mònica), Zugna, D. (Daniela), Basagaña, X. (Xavier), Nieuwenhuijsen, M. (Mark), Ibarluzea, J.M. (Jesús), Ballester, F. (Ferran), and Sunyer, J. (Jordi)

Abstract

BACKGROUND: Natural environments, including green spaces, may have beneficial impacts on brain development. However, longitudinal evidence of an association between long-term exposure to green spaces and cognitive development (including attention) in children is limited. OBJECTIVES: We evaluated the association between lifelong residential exposure to green space and attention during preschool and early primary school years. METHODS: This longitudinal study was based on data from two well-established population-based birth cohorts in Spain. We assessed lifelong exposure to residential surrounding greenness and tree cover as the average of satellite-based normalized difference vegetation index and vegetation continuous fields, respectively, surrounding the child's residential addresses at birth, 4-5 y, and 7 y. Attention was characterized using two computer-based tests: Conners' Kiddie Continuous Performance Test (K-CPT) at 4-5 y (n=888) and Attentional Network Task (ANT) at 7 y (n=987). We used adjusted mixed effects models with cohort random effects to estimate associations between exposure to greenness and attention at ages 4-5 and 7 y. RESULTS: Higher lifelong residential surrounding greenness was associated with fewer K-CPT omission errors and lower K-CPT hit reaction time-standard error (HRT-SE) at 4-5 y and lower ANT HRT-SE at 7 y, consistent with better attention. This exposure was not associated with K-CPT commission errors or with ANT omission or commission errors. Associations with residential surrounding tree cover also were close to the null, or were negative (for ANT HRT-SE) but not statistically significant. CONCLUSION: Exposure to residential surrounding greenness was associated with better scores on tests of attention at 4-5 y and 7 y of age in our longitudinal cohort. https://doi.org/10.1289/EHP694.

Published
2017
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26. Lifelong Residential Exposure to Green Space and Attention: A Population-based Prospective Study

Author

Dadvand, P, Tischer, C, Estarlich, M, Llop, S, Dalmau-Bueno, A, Lopez-Vicente, M, Valentin, A, de Keijzer, C, Fernandez-Somoano, A, Lertxundi, N, Rodriguez-Dehli, C, Gascon, M, Guxens Junyent, Monica, Zugna, D, Basagana, X, Nieuwenhuijsen, MJ, Ibarluzea, J, Ballester, F, Sunyer, J, Dadvand, P, Tischer, C, Estarlich, M, Llop, S, Dalmau-Bueno, A, Lopez-Vicente, M, Valentin, A, de Keijzer, C, Fernandez-Somoano, A, Lertxundi, N, Rodriguez-Dehli, C, Gascon, M, Guxens Junyent, Monica, Zugna, D, Basagana, X, Nieuwenhuijsen, MJ, Ibarluzea, J, Ballester, F, and Sunyer, J

Published
2017

27. Mode of delivery and asthma at school age in nine European birth cohorts

Author

Rusconi, F., Zugna, D., Annesi-Maesano, I., Batz, N., Barros, H., Correia, S., Duijts, L., Forastiere, F., Inskip, H., Kelleher, C.C., Larsen, P.S., Mommers, M., Anderson, A.M.N., Penders, J., Pike, K., Porta, D., Sonnenschein-van der Voort, A., Sunyer, J., Torrent, M., Viljoen, K., Vrijheid, M., Richiardi, L., and Galassi, C.

Published
2016

28. Mediation analysis in epidemiology: Methods, interpretation and bias

Author

Richiardi, L, Bellocco, R, Zugna, D, Zugna, D., BELLOCCO, RINO, Richiardi, L, Bellocco, R, Zugna, D, Zugna, D., and BELLOCCO, RINO

Abstract

In epidemiological studies it is often necessary to disentangle the pathways that link an exposure to an outcome. Typically the aim is to identify the total effect of the exposure on the outcome, the effect of the exposure that acts through a given set of mediators of interest (indirect effect) and the effect of the exposure unexplained by those same mediators (direct effect). The traditional approach to mediation analysis is based on adjusting for the mediator in standard regression models to estimate the direct effect. However, several methodological papers have shown that under a number of circumstances this traditional approach may produce flawed conclusions. Through a better understanding of the causal structure of the variables involved in the analysis, with a formal definition of direct and indirect effects in a counterfactual framework, alternative analytical methods have been introduced to improve the validity and interpretation of mediation analysis. In this paper, we review and discuss the impact of the three main sources of potential bias in the traditional approach to mediation analyses: (i) mediator-outcome confounding;(ii) exposure-mediator interaction and (iii) mediator-outcome confounding affected by the exposure. We provide examples and discuss the impact these sources have in terms of bias. © The Author 2013; all rights reserved.

Published
2013

30. Smoking addiction and the risk of upper-aerodigestive-tract cancer in a multicenter case-control study

Author

Lee, Y.C., Zugna, D., Richiardi, L., Merletti, F., Marron, M., Ahrens, W., Pohlabeln, H., Lagiou, P., Trichopoulos, D., Agudo, A., Castellsague, X., Betka, J., Holcatova, I., Kjaerheim, K., Macfarlane, G.J., Macfarlane, T.V., Talamini, R., Barzan, ., Canova, C., Simonato, L., Conway, D.I., McKinney, P.A., Thomson, P., Znaor, Ariana, Healy, C.M., McCartan, B.E., Boffetta, P., Brennan, P., Hashibe, M., Lee, Y.-C.A., Zugna, D., Richiardi, L., Merletti, F., Marron, M., Ahrens, W., Pohlabeln, H., Lagiou, P., Trichopoulos, D., Agudo, A., Castellsague, X., Betka, J., Holcatova, I., Kjaerheim, K., Macfarlane, G.J., Macfarlane, T.V., Talamini, R., Barzan, L., Canova, C., Simonato, L., Conway, D.I., McKinney, P.A., Thomson, P., Znaor, A., Healy, C.M., McCartan, B.E., Boffetta, P., Brennan, P., and Hashibe, M.

Subjects
Adult, Male, Alcohol Drinking, alcohol, Smoking, Middle Aged, tobacco, Europe, Logistic Models, smoking addiction, upper-aerodigestive-tract cancer, Head and Neck Neoplasms, Risk Factors, Case-Control Studies, Surveys and Questionnaires, Carcinoma, Squamous Cell, Humans, Female, Mouth Neoplasms, upper-aerodigestive-tract (UADT) cancers, Aged
Abstract

Although previous studies on tobacco and alcohol and the risk of upper-aerodigestive-tract (UADT) cancers have clearly shown dose-response relations with the frequency and duration of tobacco and alcohol, studies on addiction to tobacco smoking itself as a risk factor for UADT cancer have not been published, to our knowledge. The aim of this report is to assess whether smoking addiction is an independent risk factor or a refinement to smoking variables (intensity and duration) for UADT squamous cell carcinoma (SCC) risk in the multicenter case-control study (ARCAGE) in Western Europe. The analyses included 1,586 ever smoking UADT SCC cases and 1,260 ever smoking controls. Addiction was measured by a modified Fagerström score (first cigarette after waking up, difficulty refraining from smoking in places where it is forbidden and cigarettes per day). Adjusted odds ratios (ORs) and 95% confidence intervals (95% CIs) for UADT cancers with addiction variables were estimated with unconditional logistic regression. Among current smokers, the participants who smoked their first cigarette within 5 min of waking up were two times more likely to develop UADT SCC than those who smoked 60 min after waking up. Greater tobacco smoking addiction was associated with an increased risk of UADT SCC among current smokers (OR = 3.83, 95% CI: 2.56-5.73 for score of 3-7 vs. 0) but not among former smokers. These results may be consistent with a residual effect of smoking that was not captured by the questionnaire responses (smoking intensity and smoking duration) alone, suggesting addiction a refinement to smoking variables. What's new? Previous studies have clearly shown dose-response relationships between tobacco/alcohol use and the risk of upper-aerodigestive- tract (UADT) cancers, but these studies have focused only on the variables of frequency and duration of use. In this study, the authors asked whether addiction to smoking might be an independent risk factor. They found that addiction was indeed associated with UADT cancer risk among current smokers. This addiction-cancer association suggests that it is important to include questions that elicit information regarding smoking addiction when accounting for smoking effect through questionnaire information. Copyright © 2013 UICC.

Published
2013

31. Maternal anxiety, depression and sleep disorders before and during pregnancy, and preschool ADHD symptoms in the NINFEA birth cohort study.

Author

Vizzini, L., Popovic, M., Zugna, D., Vitiello, B., Trevisan, M., Pizzi, C., Rusconi, F., Gagliardi, L., Merletti, F., and Richiardi, L.

Subjects
SLEEP disorders, MATERNAL age, COHORT analysis, PREGNANCY, MENTAL illness
Abstract

Aims.: Maternal mental disorders have been associated with the risk of attention-deficit/hyperactivity disorder (ADHD) in children. Within the context of a mother–child cohort, we examined whether maternal anxiety, depression and sleep disorders are associated with pre-school ADHD symptoms. Methods.: The study included 3634 singletons from the Italian NINFEA (Nascita e INFanzia: gli Effetti dell'Ambiente') cohort. Maternal doctor-diagnosed anxiety, depression and sleep disorders before and during pregnancy were assessed from the questionnaires completed during pregnancy and 6 months after delivery. Mothers rated child ADHD symptoms at 4 years of age, according to the Diagnostic and Statistical Manual of Mental Disorders. Hyperactive–impulsive (ADHD-H), inattentive (ADHD-I) and total ADHD scores were analysed in the models adjusted for child's gender, first-born status, maternal age, education, alcohol consumption and smoking during pregnancy. Results.: The total ADHD score at age 4 was associated with maternal lifetime anxiety (17.1% percentage difference in score compared with never; 95% CI 7.3–27.9%), sleep disorders (35.7%; 95% CI 10.7–66.5%) and depression (17.5%; 95% CI 3.2–33.8%). Similar positive associations were observed also for ADHD-H and ADHD-I traits, with slightly attenuated associations between maternal sleep disorders and child ADHD-I score, and maternal depression and both ADHD scores. All the estimates were enhanced when the disorders were active during pregnancy and attenuated for disorders active only during the pre-pregnancy period. Conclusions.: Maternal anxiety, depression and sleep disorders are associated with a relative increase in the number of ADHD-H, ADHD-I and total ADHD symptoms in preschoolers. [ABSTRACT FROM AUTHOR]

Published
2019
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32. Sources of confounding in life course epidemiology.

Author

Santos, S., Zugna, D., Pizzi, C., and Richiardi, L.

Abstract

In epidemiologic analytical studies, the primary goal is to obtain a valid and precise estimate of the effect of the exposure of interest on a given outcome in the population under study. A crucial source of violation of the internal validity of a study involves bias arising from confounding, which is always a challenge in observational research, including life course epidemiology. The increasingly popular approach of meta-analyzing individual participant data from several observational studies also brings up to discussion the problem of confounding when combining data from different populations. In this study, we review and discuss the most common sources of confounding in life course epidemiology: (i) confounding by indication, (ii) impact of baseline selection on confounding, (iii) time-varying confounding and (iv) mediator–outcome confounding. We also discuss the issue of addressing confounding in the context of an individual participant data meta-analysis. [ABSTRACT FROM AUTHOR]

Published
2019
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33. The independent role of prenatal and postnatal exposure to active and passive smoking on the development of early wheeze in children

Author

Vardavas, C. I., Hohmann, C., Patelarou, E., Martinez, D., Henderson, A. J., Granell, R., Sunyer, J., Torrent, M., Fantini, M. P., Gori, D., Annesi-Maesano, I., Slama, R., Duijts, L., de Jongste, J. C., Aurrekoetxea, J. J., Basterrechea, M., Morales, E., Ballester, F., Murcia, M., Thijs, C., Mommers, M., Kuehni, C. E., Gaillard, E. A., Tischer, C., Heinrich, J., Pizzi, C., Zugna, D., Gehring, U., Wijga, Alet H., Chatzi, L., Vassilaki, M., Bergstrom, A., Eller, E., Lau, S., Keil, T., Nieuwenhuijsen, M., Kogevinas, M., Vardavas, C. I., Hohmann, C., Patelarou, E., Martinez, D., Henderson, A. J., Granell, R., Sunyer, J., Torrent, M., Fantini, M. P., Gori, D., Annesi-Maesano, I., Slama, R., Duijts, L., de Jongste, J. C., Aurrekoetxea, J. J., Basterrechea, M., Morales, E., Ballester, F., Murcia, M., Thijs, C., Mommers, M., Kuehni, C. E., Gaillard, E. A., Tischer, C., Heinrich, J., Pizzi, C., Zugna, D., Gehring, U., Wijga, Alet H., Chatzi, L., Vassilaki, M., Bergstrom, A., Eller, E., Lau, S., Keil, T., Nieuwenhuijsen, M., and Kogevinas, M.

Abstract

Maternal smoking during pregnancy increases childhood asthma risk, but health effects in children of nonsmoking mothers passively exposed to tobacco smoke during pregnancy are unclear. We examined the association of maternal passive smoking during pregnancy and wheeze in children aged <= 2 years. Individual data of 27 993 mother-child pairs from 15 European birth cohorts were combined in pooled analyses taking into consideration potential confounders. Children with maternal exposure to passive smoking during pregnancy and no other smoking exposure were more likely to develop wheeze up to the age of 2 years (OR 1.11, 95% CI 1.03-1.20) compared with unexposed children. Risk of wheeze was further increased by children's postnatal passive smoke exposure in addition to their mothers' passive exposure during pregnancy (OR 1.29, 95% CI 1.19-1.40) and highest in children with both sources of passive exposure and mothers who smoked actively during pregnancy (OR 1.73, 95% CI 1.59-1.88). Risk of wheeze associated with tobacco smoke exposure was higher in children with an allergic versus nonallergic family history. Maternal passive smoking exposure during pregnancy is an independent risk factor for wheeze in children up to the age of 2 years. Pregnant females should avoid active and passive exposure to tobacco smoke for the benefit of their children's health.

Published
2016

34. The independent role of prenatal and postnatal exposure to active and passive smoking on the development of early wheeze in children

Author

LS IRAS EEPI ME (Milieu epidemiologie), Geneeskunde van gezelschapsdieren, dIRAS RA-2, Vardavas, C. I., Hohmann, C., Patelarou, E., Martinez, D., Henderson, A. J., Granell, R., Sunyer, J., Torrent, M., Fantini, M. P., Gori, D., Annesi-Maesano, I., Slama, R., Duijts, L., de Jongste, J. C., Aurrekoetxea, J. J., Basterrechea, M., Morales, E., Ballester, F., Murcia, M., Thijs, C., Mommers, M., Kuehni, C. E., Gaillard, E. A., Tischer, C., Heinrich, J., Pizzi, C., Zugna, D., Gehring, U., Wijga, Alet H., Chatzi, L., Vassilaki, M., Bergstrom, A., Eller, E., Lau, S., Keil, T., Nieuwenhuijsen, M., Kogevinas, M., LS IRAS EEPI ME (Milieu epidemiologie), Geneeskunde van gezelschapsdieren, dIRAS RA-2, Vardavas, C. I., Hohmann, C., Patelarou, E., Martinez, D., Henderson, A. J., Granell, R., Sunyer, J., Torrent, M., Fantini, M. P., Gori, D., Annesi-Maesano, I., Slama, R., Duijts, L., de Jongste, J. C., Aurrekoetxea, J. J., Basterrechea, M., Morales, E., Ballester, F., Murcia, M., Thijs, C., Mommers, M., Kuehni, C. E., Gaillard, E. A., Tischer, C., Heinrich, J., Pizzi, C., Zugna, D., Gehring, U., Wijga, Alet H., Chatzi, L., Vassilaki, M., Bergstrom, A., Eller, E., Lau, S., Keil, T., Nieuwenhuijsen, M., and Kogevinas, M.

Published
2016

35. Marriage and parenthood among childhood cancer survivors: a report from the Italian AIEOP Off-Therapy Registry

Author

Pivetta, E, Maule, Mm, Pisani, P, Zugna, D, Haupt, R, Jankovic, M, Aricò, M, Casale, F, Clerico, A, Cordero di Montezemolo, L, Kiren, V, Locatelli, F, Palumbo, G, Pession, A, Pillon, M, Santoro, N, Terenziani, M, Valsecchi, Mg, Dama, E, Magnani, C, Merletti, F, Pastore, G, Fagioli, F, Bona, G, Dini, G, Carnelli, V, Biondi, A, Zecca, M, Conter, V, Porta, F, Fedeli, F, Massimino, M, Nespoli, L, Roncarolo, Mg, Carli, M, Cesaro, S, Memo, L, Colleselli, P, Battisti, L, Tamaro, Paolo, Mascarin, M, Nocerino, A, Izzi, G, Paolucci, P, Borgna, Pc, Vecchi, V, Abate, Me, Acquaviva, A, Favre, C, Aversa, F, Pierani, P, Felici, L, Visani, G, Fioritoni, G, Foa, R, Riccardi, R, Frega, G, Poggi, V, Amendola, G, Filosa, A, Ladogana, S, Presta, G, Pozzi, S, De Mattia, D, Consarino, C, Nobile, F, Sperlì, D, D'Angelo, P, Marino, S, Gallisai, D, Targhetta, R., Pivetta, E, Maule, M, Pisani, P, Zugna, D, Haupt, R, Jankovic, M, Aricò, M, Casale, F, Clerico, A, Cordero di Montezemolo, L, Kiren, V, Locatelli, F, Palumbo, G, Pession, A, Pillon, M, Santoro, N, Terenziani, M, Valsecchi, M, Dama, E, Magnani, C, Merletti, F, Pastore, G, Maule, Mm, Valsecchi, Mg, Fagioli, F, Bona, G, Dini, G, Carnelli, V, Biondi, A, Zecca, M, Conter, V, Porta, F, Fedeli, F, Massimino, M, Nespoli, L, Roncarolo, Mg, Carli, M, Cesaro, S, Memo, L, Colleselli, P, Battisti, L, Tamaro, Paolo, Mascarin, M, Nocerino, A, Izzi, G, Paolucci, P, Borgna, Pc, Vecchi, V, Abate, Me, Acquaviva, A, Favre, C, Aversa, F, Pierani, P, Felici, L, Visani, G, Fioritoni, G, Foa, R, Riccardi, R, Frega, G, Poggi, V, Amendola, G, Filosa, A, Ladogana, S, Presta, G, Pozzi, S, De Mattia, D, Consarino, C, Nobile, F, Sperlì, D, D'Angelo, P, Marino, S, Gallisai, D, and Targhetta, R.

Subjects
Adult, Male, Parents, Pediatrics, medicine.medical_specialty, Total fertility rate, media_common.quotation_subject, Population, Editorials and Perspectives, Fertility, off-therapy, cancer survival, Cohort Studies, Quality of life, Marriage and parenthood, Medicine, Humans, cancer, cancer survivors, childhood, Registries, Survivors, Marriage, education, Child, media_common, education.field_of_study, business.industry, Infant, Newborn, Infant, Hematology, Original Articles, Middle Aged, childhood cancer, fertility, long-term survivors, marriage, quality of life, El Niño, Italy, Child, Preschool, Hematologic Neoplasms, Cohort, Marital status, Female, business, Cohort study, Follow-Up Studies
Abstract

Background The aim of this study was to describe the patterns of marriage and parenthood in a cohort of childhood cancer survivors included in the Off-Therapy Registry maintained by the Italian Association of Pediatric Hematology and Oncology. Design and Methods We analyzed a cohort of 6,044 patients diagnosed with cancer between 1960 and 1998, while aged 0 to 14 years and who were 18 years old or older by December 2003. They were followed up through the regional vital statistics registers until death or the end of follow up (October 30, 2006), whichever occurred first, and their marital status and date of birth of their children were recorded. The cumulative probabilities of being married and having a first child were computed by gender and compared by tumor type within the cohort. Marriage and fertility rates (the latter defined as the number of live births per woman-year) were compared with those of the Italian population of the same age, gender, area of residence and calendar period by means of the observed to expected (O/E) ratios. Results During the follow-up period, 4,633 (77%) subjects had not married. The marriage O/E ratios were 0.56 (95% CI: 0.51-0.61) and 0.70 (95% CI: 0.65-0.76) among men and women, respectively. Overall, 263 men had 367 liveborn children, and 473 women had 697 liveborn children. The female fertility O/E ratio was 0.57 (95% CI: 0.53-0.62) overall, and 1.08 (95% CI: 0.99-1.17) when analyses were restricted to married/cohabiting women Conclusions Childhood cancer survivors are less likely to marry and to have children than the general population, confirming the life-long impact of their previous disease on their social behavior and choices. The inclusion of counseling in the strategies of management and long-term surveillance of childhood cancer patients could be beneficial to survivors as they approach adulthood. ©2011 Ferrata Storti Foundation.

Published
2011

36. Intensified immunosuppression with ATG reduces graft failure without affecting immune reconstitution or infections in high-risk beta thalassaemia patients after HLA-identical sibling HSCT

Author

Biral E, Cappelli B, Zugna D, Chiesa R, Biffi A, Zito L, Fleischhauer K, Bacchetta R, Fumagalli L, Di Serio C, Roncarolo MG, Aiuti A, Marktel S., CICERI , FABIO, Biral, E, Cappelli, B, Zugna, D, Chiesa, R, Biffi, A, Zito, L, Fleischhauer, K, Bacchetta, R, Fumagalli, L, Di Serio, C, Ciceri, Fabio, Roncarolo, Mg, Aiuti, A, and Marktel, S.

Published
2010

37. The independent role of prenatal and postnatal exposure to active and passive smoking on the development of early wheeze in children

Author

Vardavas, C.I., primary, Hohmann, C., additional, Patelarou, E., additional, Martinez, D., additional, Henderson, A.J., additional, Granell, R., additional, Sunyer, J., additional, Torrent, M., additional, Fantini, M.P., additional, Gori, D., additional, Annesi-Maesano, I., additional, Slama, R., additional, Duijts, L., additional, de Jongste, J.C., additional, Aurrekoetxea, J.J., additional, Basterrechea, M., additional, Morales, E., additional, Ballester, F., additional, Murcia, M., additional, Thijs, C., additional, Mommers, M., additional, Kuehni, C.E., additional, Gaillard, E.A., additional, Tischer, C., additional, Heinrich, J., additional, Pizzi, C., additional, Zugna, D., additional, Gehring, U., additional, Wijga, A., additional, Chatzi, L., additional, Vassilaki, M., additional, Bergström, A., additional, Eller, E., additional, Lau, S., additional, Keil, T., additional, Nieuwenhuijsen, M., additional, and Kogevinas, M., additional

Published
2016
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38. Maternal occupation during pregnancy, birth weight, and length of gestation: Combined analysis of 13 European birth cohorts

Author

Casas, M. (Miguel), Cordier, S. (Sylvaine), Martinez, D. (David), Barros, H. (Henrique), Bonde, J.P. (Jens Peter), Burdorf, A. (Alex), Costet, N. (Nathalie), dos Santos, A.C. (Ana Cristina), Danileviciute, A. (Asta), Eggesbø, M. (Merete), Fernandez, M.F. (Mariana), Fevotte, J. (Joelle), García, A.M. (Ana M.), Grazuleviciene, R. (Regina), Hallner, E. (Eva), Hanke, W. (Wojciech), Kogevinas, M. (Manolis), Kull, C.A. (Christian), Larsen, P.S. (Pernille), Melaki, V. (Vasiliki), Monfort, C. (Christine), Nordby, K.-C. (Karl-Christian), Nybo Andersen, A.-M. (Anne-Marie), Patelarou, E. (Evridiki), Polanska, K. (Kinga), Richiardi, L. (Lorenzo), Marina, L.S. (Loreto Santa), Snijder, C.A. (Claudia), Tardón, A. (Adonina), Eijsden, M. (Manon) van, Vrijkotte, T.G.M. (Tanja), Zugna, D. (Daniela), Nieuwenhuijsen, M. (Mark), Vrijheid, M. (Martine), Casas, M. (Miguel), Cordier, S. (Sylvaine), Martinez, D. (David), Barros, H. (Henrique), Bonde, J.P. (Jens Peter), Burdorf, A. (Alex), Costet, N. (Nathalie), dos Santos, A.C. (Ana Cristina), Danileviciute, A. (Asta), Eggesbø, M. (Merete), Fernandez, M.F. (Mariana), Fevotte, J. (Joelle), García, A.M. (Ana M.), Grazuleviciene, R. (Regina), Hallner, E. (Eva), Hanke, W. (Wojciech), Kogevinas, M. (Manolis), Kull, C.A. (Christian), Larsen, P.S. (Pernille), Melaki, V. (Vasiliki), Monfort, C. (Christine), Nordby, K.-C. (Karl-Christian), Nybo Andersen, A.-M. (Anne-Marie), Patelarou, E. (Evridiki), Polanska, K. (Kinga), Richiardi, L. (Lorenzo), Marina, L.S. (Loreto Santa), Snijder, C.A. (Claudia), Tardón, A. (Adonina), Eijsden, M. (Manon) van, Vrijkotte, T.G.M. (Tanja), Zugna, D. (Daniela), Nieuwenhuijsen, M. (Mark), and Vrijheid, M. (Martine)

Abstract

Objectives We assessed whether maternal employment during pregnancy – overall and in selected occupational sectors – is associated with birth weight, small for gestational age (SGA), term low birth weight (LBW), length of gestation, and preterm delivery in a population-based birth cohort design. Methods We used data from >200 000 mother-child pairs enrolled in 13 European birth cohorts and compared employed versus non-employed women. Among employees, we defined groups of occupations representing the main sectors of employment for women where potential reproductive hazards are considered to be present. The comparison group comprised all other employed women not included in the occupational sector being assessed. We performed meta-analyses of cohort-specific estimates and explored heterogeneity. Results Employees had a lower risk of preterm delivery than non-employees [adjusted odds ratio (ORadj) 0.86, 95% confidence interval (95% CI) 0.81–0.91]. Working in most of the occupational sectors studied was not associated with adverse birth outcomes. Being employed as a nurse was associated with lower risk SGA infants (ORadj 0.91, 95% CI 0.84–0.99) whereas food industry workers had an increased risk of preterm delivery (ORadj 1.50, 95% CI 1.12–2.02). There was little evidence for heterogeneity between cohorts. Conclusions This study suggests that, overall, employment during pregnancy is associated with a reduction in the risk of preterm birth and that work in certain occupations may affect pregnancy outcomes. This exploratory study provides an important platform on which to base further prospective studies focused on the potential consequences of maternal occupational exposures during pregnancy on child development.

Published
2015
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39. Maternal occupation during pregnancy, birth weight, and length of gestation: combined analysis of 13 European birth cohorts

Author

Casas Sanahuja, Maria, Cordier, S, Martinez, D, Barros, H, Bonde, JP, Burdorf, Lex, Costet, N, dos Santos, AC, Danileviciute, A, Eggesbo, M, Fernandez, MF, Fevotte, J, Garcia, AM, Grazuleviciene, R, Hallner, E, Hanke, W, Kogevinas, M, Kull, I, Larsen, PS, Melaki, V, Monfort, C, Nordby, KC, Andersen, AMN, Patelarou, E, Polanska, K, Richiardi, L, Marina, LS, Snijder, Claudia, Tardon, A, van Eijsden, M, Vrijkotte, TGM, Zugna, D, Nieuwenhuijsen, M, Vrijheid, M, Casas Sanahuja, Maria, Cordier, S, Martinez, D, Barros, H, Bonde, JP, Burdorf, Lex, Costet, N, dos Santos, AC, Danileviciute, A, Eggesbo, M, Fernandez, MF, Fevotte, J, Garcia, AM, Grazuleviciene, R, Hallner, E, Hanke, W, Kogevinas, M, Kull, I, Larsen, PS, Melaki, V, Monfort, C, Nordby, KC, Andersen, AMN, Patelarou, E, Polanska, K, Richiardi, L, Marina, LS, Snijder, Claudia, Tardon, A, van Eijsden, M, Vrijkotte, TGM, Zugna, D, Nieuwenhuijsen, M, and Vrijheid, M

Abstract

Objectives We assessed whether maternal employment during pregnancy overall and in selected occupational sectors - is associated with birth weight, small for gestational age (SGA), term low birth weight (LBW), length of gestation, and preterm delivery in a population-based birth cohort design. Methods We used data from >200 000 mother-child pairs enrolled in 13 European birth cohorts and compared employed versus non-employed women. Among employees, we defined groups of occupations representing the main sectors of employment for women where potential reproductive hazards are considered to be present. The comparison group comprised all other employed women not included in the occupational sector being assessed. We performed meta-analyses of cohort-specific estimates and explored heterogeneity. Results Employees had a lower risk of preterm delivery than non-employees [adjusted odds ratio (ORadj) 0.86, 95% confidence interval (95% CI) 0.81-0.91]. Working in most of the occupational sectors studied was not associated with adverse birth outcomes. Being employed as a nurse was associated with lower risk SGA infants (ORadj, 0.91, 95% CI 0.84-0.99) whereas food industry workers had an increased risk of preterm delivery (ORadj 1.50, 95% CI 1.12-2.02). There was little evidence for heterogeneity between cohorts. Conclusions This study suggests that, overall, employment during pregnancy is associated with a reduction in the risk of preterm birth and that work in certain occupations may affect pregnancy outcomes. This exploratory study provides an important platform on which to base further prospective studies focused on the potential consequences of maternal occupational exposures during pregnancy on child development.

Published
2015

41. Time to virological failure, treatment change and interruption for individuals treated within 12 months of HIV seroconversion and in chronic infection

Author

Zugna, D, Geskus, RB, De Stavola, B, Rosinska, M, Bartmeyer, B, Boufassa, F, Chaix, ML, Babiker, A, Porter, K, García de Olalla P., and CASCADE Collaboration EuroCoord

Abstract

Background: Estimates of treatment failure, change and interruption are lacking for individuals treated in early HIV infection. Methods: Using CASCADE data, we compared the effect of treatment in early infection (within 12 months of seroconversion) with that seen in chronic infection on risk of virological failure, change and interruption. Failure was defined as two subsequent measures of HIV RNA> 1,000 copies/ml following suppression (< 500 copies/ml), or > 500 copies/ml 6 months following initiation. Treatment change and interruption were defined as modification or interruption lasting > 1 week. In multivariable competing risks proportional subdistribution hazards models, we adjusted for combination antiretroviral therapy (cART) class, sex, risk group, age, CD4(+) T-cell count, HIV RNA and calendar period at treatment initiation. Results: Of 1,627 individuals initiating cART early (median 1.8 months from seroconversion), 159, 395 and 692 failed, changed and interrupted therapy, respectively. For 2,710 individuals initiating cART in chronic infection (median 35.9 months from seroconversion), the corresponding values were 266, 569 and 597. Adjusted hazard ratios (HRs; 95% CIs) for treatment failure and change were similar between the two treatment groups (0.93 [0.72, 1.20] and 1.06 [0.91, 1.24], respectively). There was an increasing trend in rates of interruption over calendar time for those treated early, and a decreasing trend for those starting treatment in chronic infection. Consequently, compared with chronic infection, treatment interruption was similar for early starters in the early cART period, but the relative hazard increased over calendar time (1.54 [1.33, 1.79] in 2000). Conclusions: Individuals initiating treatment in early HIV infection are more likely to interrupt treatment than those initiating later. However, rates of failure and treatment change were similar between the two groups.

Published
2012

42. Maternal complications in pregnancy and wheezing in early childhood: a pooled analysis of 14 birth cohorts

Author

Zugna, D., primary, Galassi, C., additional, Annesi-Maesano, I., additional, Baiz, N., additional, Barros, H., additional, Basterrechea, M., additional, Correia, S., additional, Duijts, L., additional, Esplugues, A., additional, Fantini, M. P., additional, Forastiere, F., additional, Gascon, M., additional, Gori, D., additional, Inskip, H., additional, Larsen, P. S., additional, Mommers, M., additional, Nybo Andersen, A.-M., additional, Penders, J., additional, Petersen, M. S., additional, Pike, K., additional, Porta, D., additional, Sonnenschein-van der Voort, A., additional, Steuerwald, U., additional, Sunyer, J., additional, Torrent, M., additional, Vrijheid, M., additional, Richiardi, L., additional, and Rusconi, F., additional

Published
2015
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50. Marriage and parenthood among subjects cured of childhood cancer: a report from the Italian AIEOP Off-Therapy Registry

Author

Pivetta, EMANUELE EMILIO, Maule, MILENA MARIA, Pisani, Paola, Zugna, Daniela, Haupt, R, Jankovic, M, Arico', M, Casale, F, Clerico, A, CORDERO DI MONTEZEMOLO, Luca, Kiren, V, Locatelli, F, Palumbo, G, Pession, A, Pillon, M, Santoro, N, Terenziani, M, Valsecchi, Mg, Dama, Elisa, Magnani, C, Merletti, Franco, Pastore, G., Pivetta E., Maule MM., Pisani P., Zugna D., Haupt R., Jankovic M., Arico' M., Casale F., Clerico A., Cordero di Montezemolo L., Kiren V., Locatelli F., Palumbo G., Pession A., Pillon M., Santoro N., Terenziani M., Valsecchi MG., Dama E., Magnani C., Merletti F., Pastore G., Pivetta, E, Maule, Mm, Pisani, P, Zugna, D, Haupt, R, Jankovic, M, Aricò, M, Casale, Fiorina, Clerico, A, CORDERO DI MONTEZEMOLO, L, Kiren, V, Locatelli, F, Palumbo, G, Pession, A, Pillon, M, Santoro, N, Terenziani, M, Valsecchi, Mg, Dama, E, Magnani, C, Merletti, F, and Pastore, G.

Subjects
Quality of life, Fertility, childhood cancer, Marriage, Long-term survivors, childhood cancer, marriage, fertility, long-term survivors, quality of life
Abstract

The aim of this study was to describe the patterns of marriage and parenthood in a cohort of childhood cancer survivors included in the Off-Therapy Registry maintained by the Italian Association of Pediatric Hematology and Oncology. Design and Methods We analyzed a cohort of 6,044 patients diagnosed with cancer between 1960 and 1998, while aged 0 to 14 years and who were 18 years old or older by December 2003. They were followed up through the regional vital statistics registers until death or the end of follow up (October 30, 2006), whichever occurred first, and their marital status and date of birth of their children were recorded. The cumulative probabilities of being married and having a first child were computed by gender and compared by tumor type within the cohort. Marriage and fertility rates (the latter defined as the number of live births per woman-year) were compared with those of the Italian population of the same age, gender, area of residence and calendar period by means of the observed to expected (O/E) ratios. Results During the follow-up period, 4,633 (77%) subjects had not married. The marriage O/E ratios were 0.56 (95% CI: 0.51-0.61) and 0.70 (95% CI: 0.65-0.76) among men and women, respectively. Overall, 263 men had 367 liveborn children, and 473 women had 697 liveborn children. The female fertility O/E ratio was 0.57 (95% CI: 0.53-0.62) overall, and 1.08 (95% CI: 0.99-1.17) when analyses were restricted to married/cohabiting women Conclusions Childhood cancer survivors are less likely to marry and to have children than the general population, confirming the life-long impact of their previous disease on their social behavior and choices. The inclusion of counseling in the strategies of management and long-term surveillance of childhood cancer patients could be beneficial to survivors as they approach adulthood.

Published
2011

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