227 results on '"Zugman, André"'
Search Results
2. Volume of subcortical brain regions in social anxiety disorder: mega-analytic results from 37 samples in the ENIGMA-Anxiety Working Group.
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Groenewold, Nynke, Bas-Hoogendam, Janna, Amod, Alyssa, Laansma, Max, Van Velzen, Laura, Aghajani, Moji, Hilbert, Kevin, Oh, Hyuntaek, Salas, Ramiro, Jackowski, Andrea, Pan, Pedro, Salum, Giovanni, Blair, James, Blair, Karina, Hirsch, Joy, Pantazatos, Spiro, Schneier, Franklin, Talati, Ardesheer, Roelofs, Karin, Volman, Inge, Blanco-Hinojo, Laura, Cardoner, Narcís, Pujol, Jesus, Beesdo-Baum, Katja, Ching, Christopher, Thomopoulos, Sophia, Jansen, Andreas, Kircher, Tilo, Krug, Axel, Nenadić, Igor, Stein, Frederike, Dannlowski, Udo, Grotegerd, Dominik, Lemke, Hannah, Meinert, Susanne, Winter, Alexandra, Erb, Michael, Kreifelts, Benjamin, Gong, Qiyong, Lui, Su, Zhu, Fei, Mwangi, Benson, Soares, Jair, Wu, Mon-Ju, Bayram, Ali, Canli, Mesut, Tükel, Raşit, Westenberg, P, Heeren, Alexandre, Cremers, Henk, Hofmann, David, Straube, Thomas, Doruyter, Alexander, Lochner, Christine, Peterburs, Jutta, Van Tol, Marie-José, Gur, Raquel, Kaczkurkin, Antonia, Larsen, Bart, Satterthwaite, Theodore, Filippi, Courtney, Gold, Andrea, Harrewijn, Anita, Zugman, André, Bülow, Robin, Grabe, Hans, Völzke, Henry, Wittfeld, Katharina, Böhnlein, Joscha, Dohm, Katharina, Kugel, Harald, Schrammen, Elisabeth, Zwanzger, Peter, Leehr, Elisabeth, Sindermann, Lisa, Ball, Tali, Fonzo, Gregory, Paulus, Martin, Stein, Murray, Klumpp, Heide, Phan, K, Furmark, Tomas, Månsson, Kristoffer, Manzouri, Amirhossein, Avery, Suzanne, Blackford, Jennifer, Clauss, Jacqueline, Feola, Brandee, Harper, Jennifer, Sylvester, Chad, Lueken, Ulrike, Veltman, Dick, Winkler, Anderson, Jahanshad, Neda, Pine, Daniel, Thompson, Paul, Stein, Dan, Van der Wee, Nic, and Simmons, Alan
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Adult ,Adolescent ,Humans ,Phobia ,Social ,Magnetic Resonance Imaging ,Brain ,Anxiety ,Neuroimaging - Abstract
There is limited convergence in neuroimaging investigations into volumes of subcortical brain regions in social anxiety disorder (SAD). The inconsistent findings may arise from variations in methodological approaches across studies, including sample selection based on age and clinical characteristics. The ENIGMA-Anxiety Working Group initiated a global mega-analysis to determine whether differences in subcortical volumes can be detected in adults and adolescents with SAD relative to healthy controls. Volumetric data from 37 international samples with 1115 SAD patients and 2775 controls were obtained from ENIGMA-standardized protocols for image segmentation and quality assurance. Linear mixed-effects analyses were adjusted for comparisons across seven subcortical regions in each hemisphere using family-wise error (FWE)-correction. Mixed-effects d effect sizes were calculated. In the full sample, SAD patients showed smaller bilateral putamen volume than controls (left: d = -0.077, pFWE = 0.037; right: d = -0.104, pFWE = 0.001), and a significant interaction between SAD and age was found for the left putamen (r = -0.034, pFWE = 0.045). Smaller bilateral putamen volumes (left: d = -0.141, pFWE
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- 2023
3. Atypical Brain Aging and Its Association With Working Memory Performance in Major Depressive Disorder
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Adamson, Chris, Adler, Sophie, Alexander-Bloch, Aaron F., Anagnostou, Evdokia, Anderson, Kevin M., Areces-Gonzalez, Ariosky, Astle, Duncan E., Auyeung, Bonnie, Ayub, Muhammad, Bae, Jong Bin, Ball, Gareth, Baron-Cohen, Simon, Beare, Richard, Bedford, Saashi A., Benegal, Vivek, Bethlehem, Richard A.I., Beyer, Frauke, Blangero, John, Cábez, Manuel Blesa, Boardman, James P., Borzage, Matthew, Bosch-Bayard, Jorge F., Bourke, Niall, Bullmore, Edward T., Calhoun, Vince D., Chakravarty, Mallar M., Chen, Christina, Chertavian, Casey, Chetelat, Gaël, Chong, Yap S., Corvin, Aiden, Costantino, Manuela, Courchesne, Eric, Crivello, Fabrice, Cropley, Vanessa L., Crosbie, Jennifer, Crossley, Nicolas, Delarue, Marion, Delorme, Richard, Desrivieres, Sylvane, Devenyi, Gabriel, Di Biase, Maria A., Dolan, Ray, Donald, Kirsten A., Donohoe, Gary, Dorfschmidt, Lena, Dunlop, Katharine, Edwards, Anthony D., Elison, Jed T., Ellis, Cameron T., Elman, Jeremy A., Eyler, Lisa, Fair, Damien A., Fletcher, Paul C., Fonagy, Peter, Franz, Carol E., Galan-Garcia, Lidice, Gholipour, Ali, Giedd, Jay, Gilmore, John H., Glahn, David C., Goodyer, Ian M., Grant, P.E., Groenewold, Nynke A., Gudapati, Shreya, Gunning, Faith M., Gur, Raquel E., Gur, Ruben C., Hammill, Christopher F., Hansson, Oskar, Hedden, Trey, Heinz, Andreas, Henson, Richard N., Heuer, Katja, Hoare, Jacqueline, Holla, Bharath, Holmes, Avram J., Huang, Hao, Ipser, Jonathan, Jack, Clifford R., Jr., Jackowski, Andrea P., Jia, Tianye, Jones, David T., Jones, Peter B., Kahn, Rene S., Karlsson, Hasse, Karlsson, Linnea, Kawashima, Ryuta, Kelley, Elizabeth A., Kern, Silke, Kim, Ki-Woong, Kitzbichler, Manfred G., Kremen, William S., Lalonde, François, Landeau, Brigitte, Lerch, Jason, Lewis, John D., Li, Jiao, Liao, Wei, Liston, Conor, Lombardo, Michael V., Lv, Jinglei, Mallard, Travis T., Marcelis, Machteld, Mathias, Samuel R., Mazoyer, Bernard, McGuire, Philip, Meaney, Michael J., Mechelli, Andrea, Misic, Bratislav, Morgan, Sarah E., Mothersill, David, Ortinau, Cynthia, Ossenkoppele, Rik, Ouyang, Minhui, Palaniyappan, Lena, Paly, Leo, Pan, Pedro M., Pantelis, Christos, Park, Min Tae M., Paus, Tomas, Pausova, Zdenka, Paz-Linares, Deirel, Binette, Alexa Pichet, Pierce, Karen, Qian, Xing, Qiu, Anqi, Raznahan, Armin, Rittman, Timothy, Rodrigue, Amanda, Rollins, Caitlin K., Romero-Garcia, Rafael, Ronan, Lisa, Rosenberg, Monica D., Rowitch, David H., Salum, Giovanni A., Satterthwaite, Theodore D., Schaare, H. Lina, Schabdach, Jenna, Schachar, Russell J., Schöll, Michael, Schultz, Aaron P., Seidlitz, Jakob, Sharp, David, Shinohara, Russell T., Skoog, Ingmar, Smyser, Christopher D., Sperling, Reisa A., Stein, Dan J., Stolicyn, Aleks, Suckling, John, Sullivan, Gemma, Thyreau, Benjamin, Toro, Roberto, Traut, Nicolas, Tsvetanov, Kamen A., Turk-Browne, Nicholas B., Tuulari, Jetro J., Tzourio, Christophe, Vachon-Presseau, Étienne, Valdes-Sosa, Mitchell J., Valdes-Sosa, Pedro A., Valk, Sofie L., van Amelsvoort, Therese, Vandekar, Simon N., Vasung, Lana, Vértes, Petra E., Victoria, Lindsay W., Villeneuve, Sylvia, Villringer, Arno, Vogel, Jacob W., Wagstyl, Konrad, Wang, Yin-Shan S., Warfield, Simon K., Warrier, Varun, Westman, Eric, Westwater, Margaret L., Whalley, Heather C., White, Simon R., Witte, A. Veronica, Yang, Ning, Yeo, B.T. Thomas, Yun, Hyuk Jin, Zalesky, Andrew, Zar, Heather J., Zettergren, Anna, Zhou, Juan H., Ziauddeen, Hisham, Zimmerman, Dabriel, Zugman, Andre, Zuo, Xi-Nian N., Ho, Natalie C.W., Nogovitsyn, Nikita, Metzak, Paul, Ballester, Pedro L., Hassel, Stefanie, Rotzinger, Susan, Poppenk, Jordan, Lam, Raymond W., Taylor, Valerie H., Milev, Roumen, Frey, Benicio N., Harkness, Kate L., Addington, Jean, and Kennedy, Sidney H.
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- 2024
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4. A systematic review and meta-analysis of resting-state fMRI in anxiety disorders: Need for data sharing to move the field forward
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Zugman, André, Jett, Laura, Antonacci, Chase, Winkler, Anderson M., and Pine, Daniel S.
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- 2023
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5. Translating Big Data to Clinical Outcomes in Anxiety: Potential for Multimodal Integration
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Khosravi, Parmis, Zugman, André, Amelio, Paia, Winkler, Anderson M., and Pine, Daniel S.
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- 2022
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6. Cortical and Subcortical Brain Alterations in Specific Phobia and Its Animal and Blood-Injection-Injury Subtypes: A Mega-Analysis From the ENIGMA Anxiety Working Group
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Hilbert, Kevin, primary, Boeken, Ole Jonas, additional, Langhammer, Till, additional, Groenewold, Nynke A., additional, Bas-Hoogendam, Janna Marie, additional, Aghajani, Moji, additional, Zugman, André, additional, Åhs, Fredrik, additional, Arolt, Volker, additional, Beesdo-Baum, Katja, additional, Björkstrand, Johannes, additional, Blackford, Jennifer U., additional, Blanco-Hinojo, Laura, additional, Böhnlein, Joscha, additional, Bülow, Robin, additional, Cano, Marta, additional, Cardoner, Narcis, additional, Caseras, Xavier, additional, Dannlowski, Udo, additional, Domschke, Katharina, additional, Fehm, Lydia, additional, Feola, Brandee, additional, Fredrikson, Mats, additional, Goossens, Liesbet, additional, Grabe, Hans J., additional, Grotegerd, Dominik, additional, Gur, Raquel E., additional, Hamm, Alfons O., additional, Harrewijn, Anita, additional, Heinig, Ingmar, additional, Herrmann, Martin J., additional, Hofmann, David, additional, Jackowski, Andrea P., additional, Jansen, Andreas, additional, Kaczkurkin, Antonia N., additional, Kindt, Merel, additional, Kingsley, Ellen N., additional, Kircher, Tilo, additional, Klahn, Anna L., additional, Koelkebeck, Katja, additional, Krug, Axel, additional, Kugel, Harald, additional, Larsen, Bart, additional, Leehr, Elisabeth J., additional, Leonhardt, Lieselotte, additional, Lotze, Martin, additional, Margraf, Jürgen, additional, Michałowski, Jarosław, additional, Muehlhan, Markus, additional, Nenadić, Igor, additional, Pan, Pedro M., additional, Pauli, Paul, additional, Peñate, Wenceslao, additional, Pittig, Andre, additional, Plag, Jens, additional, Pujol, Jesus, additional, Richter, Jan, additional, Rivero, Francisco L., additional, Salum, Giovanni A., additional, Satterthwaite, Theodore D., additional, Schäfer, Axel, additional, Schäfer, Judith, additional, Schienle, Anne, additional, Schneider, Silvia, additional, Schrammen, Elisabeth, additional, Schruers, Koen, additional, Schulz, Stefan M., additional, Seidl, Esther, additional, Stark, Rudolf M., additional, Stein, Frederike, additional, Straube, Benjamin, additional, Straube, Thomas, additional, Ströhle, Andreas, additional, Suchan, Boris, additional, Thomopoulos, Sophia I., additional, Ventura-Bort, Carlos, additional, Visser, Renee, additional, Völzke, Henry, additional, Wabnegger, Albert, additional, Wannemüller, André, additional, Wendt, Julia, additional, Wiemer, Julian, additional, Wittchen, Hans-Ulrich, additional, Wittfeld, Katharina, additional, Wright, Barry, additional, Yang, Yunbo, additional, Zilverstand, Anna, additional, Zwanzger, Peter, additional, Veltman, Dick J., additional, Winkler, Anderson M., additional, Pine, Daniel S., additional, Jahanshad, Neda, additional, Thompson, Paul M., additional, Stein, Dan J., additional, Van der Wee, Nic J.A., additional, and Lueken, Ulrike, additional
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- 2024
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7. Testing the Stability and Validity of an Executive Dysfunction Classification Using Task-Based Assessment in Children and Adolescents
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Manfro, Arthur Gus, Pine, Daniel S., Polanczyk, Guilherme Vanoni, Santoro, Marcos, Smoller, Jordan Wassertheil, Koenen, Karestan, Mari, Jair, Pan, Pedro Mario, Zugman, André, Schäfer, Julia Luiza, Belangero, Sintia, Gosmann, Natan Pereira, Simioni, André Rafael, Hoexter, Marcelo Queiroz, Miguel, Euripedes Constantino, Gadelha, Ary, Rohde, Luis Augusto, and Salum, Giovanni Abrahão
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- 2021
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8. Cortical surface abnormalities are different depending on the stage of schizophrenia: A cross-sectional vertexwise mega-analysis of thickness, area and gyrification
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Rosa, Pedro Gomes Penteado, Zugman, Andre, Cerqueira, Carlos Toledo, Serpa, Mauricio Henriques, de Souza Duran, Fabio Luis, Zanetti, Marcus Vinicius, Bassitt, Débora Pastore, Elkis, Helio, Crippa, José Alexandre S., Sallet, Paulo Clemente, Gattaz, Wagner Farid, Hallak, Jaime Eduardo Cecilio, Louzã, Mario Rodrigues, Gadelha, Ary, Jackowski, Andrea Parolin, Bressan, Rodrigo Affonseca, and Filho, Geraldo Busatto
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- 2021
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9. Cortical and subcortical brain structure in generalized anxiety disorder: findings from 28 research sites in the ENIGMA-Anxiety Working Group
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Harrewijn, Anita, Cardinale, Elise M., Groenewold, Nynke A., Bas-Hoogendam, Janna Marie, Aghajani, Moji, Hilbert, Kevin, Cardoner, Narcis, Porta-Casteràs, Daniel, Gosnell, Savannah, Salas, Ramiro, Jackowski, Andrea P., Pan, Pedro M., Salum, Giovanni A., Blair, Karina S., Blair, James R., Hammoud, Mira Z., Milad, Mohammed R., Burkhouse, Katie L., Phan, K. Luan, Schroeder, Heidi K., Strawn, Jeffrey R., Beesdo-Baum, Katja, Jahanshad, Neda, Thomopoulos, Sophia I., Buckner, Randy, Nielsen, Jared A., Smoller, Jordan W., Soares, Jair C., Mwangi, Benson, Wu, Mon-Ju, Zunta-Soares, Giovana B., Assaf, Michal, Diefenbach, Gretchen J., Brambilla, Paolo, Maggioni, Eleonora, Hofmann, David, Straube, Thomas, Andreescu, Carmen, Berta, Rachel, Tamburo, Erica, Price, Rebecca B., Manfro, Gisele G., Agosta, Federica, Canu, Elisa, Cividini, Camilla, Filippi, Massimo, Kostić, Milutin, Munjiza Jovanovic, Ana, Alberton, Bianca A. V., Benson, Brenda, Freitag, Gabrielle F., Filippi, Courtney A., Gold, Andrea L., Leibenluft, Ellen, Ringlein, Grace V., Werwath, Kathryn E., Zwiebel, Hannah, Zugman, André, Grabe, Hans J., Van der Auwera, Sandra, Wittfeld, Katharina, Völzke, Henry, Bülow, Robin, Balderston, Nicholas L., Ernst, Monique, Grillon, Christian, Mujica-Parodi, Lilianne R., van Nieuwenhuizen, Helena, Critchley, Hugo D., Makovac, Elena, Mancini, Matteo, Meeten, Frances, Ottaviani, Cristina, Ball, Tali M., Fonzo, Gregory A., Paulus, Martin P., Stein, Murray B., Gur, Raquel E., Gur, Ruben C., Kaczkurkin, Antonia N., Larsen, Bart, Satterthwaite, Theodore D., Harper, Jennifer, Myers, Michael, Perino, Michael T., Sylvester, Chad M., Yu, Qiongru, Lueken, Ulrike, Veltman, Dick J., Thompson, Paul M., Stein, Dan J., Van der Wee, Nic J. A., Winkler, Anderson M., and Pine, Daniel S.
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- 2021
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10. Association between spontaneous activity of the default mode network hubs and leukocyte telomere length in late childhood and early adolescence
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Rebello, Keila, Moura, Luciana M., Xavier, Gabriela, Spindola, Leticia M., Carvalho, Carolina Muniz, Hoexter, Marcelo Queiroz, Gadelha, Ary, Picon, Felipe, Pan, Pedro Mario, Zugman, André, Grassi-Oliveira, Rodrigo, Brietzke, Elisa, Belangero, Sintia I., Salum, Giovanni Abrahão, Rohde, Luis Augusto, Miguel, Eurípedes Constantino, Bressan, Rodrigo, Jackowski, Andrea, and Sato, João Ricardo
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- 2019
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11. Genetic risk for Alzheimer's disease and functional brain connectivity in children and adolescents
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Axelrud, Luiza Kvitko, Sato, João Ricardo, Santoro, Marcos Leite, Talarico, Fernanda, Pine, Daniel Samuel, Rohde, Luis Augusto, Zugman, Andre, Junior, Edson Amaro, Bressan, Rodrigo Affonseca, Grassi-Oliveira, Rodrigo, Pan, Pedro Mario, Hoffmann, Maurício Scopel, Simioni, Andre Rafael, Guinjoan, Salvador Martin, Hakonarson, Hakon, Brietzke, Elisa, Gadelha, Ary, Pellegrino da Silva, Renata, Hoexter, Marcelo Queiroz, Miguel, Euripedes Constantino, Belangero, Sintia Iole, and Salum, Giovanni Abrahão
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- 2019
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12. Imaging Social and Environmental Factors as Modulators of Brain Dysfunction: Time to Focus on Developing Non-Western Societies
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Crossley, Nicolas A., Alliende, Luz Maria, Ossandon, Tomas, Castañeda, Carmen Paz, González-Valderrama, Alfonso, Undurraga, Juan, Castro, Mariana, Guinjoan, Salvador, Díaz-Zuluaga, Ana M., Pineda-Zapata, Julián A., López-Jaramillo, Carlos, Reyes-Madrigal, Francisco, León-Ortíz, Pablo, de la Fuente-Sandoval, Camilo, Czepielewski, Leticia Sanguinetti, Gama, Clarissa S., Zugman, Andre, Gadelha, Ary, Jackowski, Andrea, and Bressan, Rodrigo
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- 2019
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13. The association between duration of breastfeeding and the trajectory of brain development from childhood to young adulthood: an 8-year longitudinal study
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Grevet, Laura Tietzmann, primary, Teixeira, Danielle Soares, additional, Pan, Pedro Mario, additional, Jackowski, Andrea Parolin, additional, Zugman, André, additional, Miguel, Euripedes Constantino, additional, Rohde, Luis Augusto, additional, and Salum, Giovanni Abrahão, additional
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- 2023
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14. Investigating brain structural patterns in first episode psychosis and schizophrenia using MRI and a machine learning approach
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de Moura, Adriana Miyazaki, Pinaya, Walter Hugo Lopez, Gadelha, Ary, Zugman, André, Noto, Cristiano, Cordeiro, Quirino, Belangero, Sintia Iole, Jackowski, Andrea P., Bressan, Rodrigo A., and Sato, João Ricardo
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- 2018
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15. Effects of the brain-derived neurotropic factor variant Val66Met on cortical structure in late childhood and early adolescence
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de Araujo, Celia Maria, Zugman, Andre, Swardfager, Walter, Belangero, Sintia Iole Nogueira, Ota, Vanessa Kiyomi, Spindola, Leticia Maria, Hakonarson, Hakon, Pellegrino, Renata, Gadelha, Ary, Salum, Giovanni Abrahão, Pan, Pedro Mario, de Moura, Luciana Monteiro, Del Aquilla, Marco, Picon, Felipe Almeida, Amaro, Edson, Jr., Sato, João Ricardo, Brietzke, Elisa, Grassi-Oliveira, Rodrigo, Rohde, Luis Augusto P., Miguel, Euripedes Constantino, Bressan, Rodrigo A., and Jackowski, Andrea Parolin
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- 2018
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16. Is adenosine associated with sudden death in schizophrenia? A new framework linking the adenosine pathway to risk of sudden death
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Gadelha, Ary, Zugman, André, Calzavara, Mariana Bendlin, de Mendonça Furtado, Remo Holanda, Scorza, Fulvio Alexandre, and Bressan, Rodrigo Afonsecca
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- 2018
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17. Treatment with a GLP−1R agonist over four weeks promotes weight loss-moderated changes in frontal-striatal brain structures in individuals with mood disorders
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Mansur, Rodrigo B., Zugman, Andre, Ahmed, Juhie, Cha, Danielle S., Subramaniapillai, Mehala, Lee, Yena, Lovshin, Julie, Lee, Jung G., Lee, Jae-Hon, Drobinin, Vladislav, Newport, Jason, Brietzke, Elisa, Reininghaus, Eva Z., Sim, Kang, Vinberg, Maj, Rasgon, Natalie, Hajek, Tomas, and McIntyre, Roger S.
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- 2017
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18. Country-level gender inequality is associated with structural differences in the brains of women and men
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Zugman, André, Alliende, LuzMaría, Medel, Vicente, Bethlehem, Richard A.I., Seidlitz, Jakob, Ringlein, Grace, Arango, Celso, Arnatkevičiūtė, Aurina, Asmal, Laila, Bellgrove, Mark, Benegal, Vivek, Bernardo, Miquel, Billeke, Pablo, Bosch-Bayard, Jorge, Bressan, Rodrigo, Busatto, GeraldoF., Castro, MarianaN., Chaim-Avancini, Tiffany, Compte, Albert, Costanzi, Monise, Czepielewski, Leticia, Dazzan, Paola, delaFuente-Sandoval, Camilo, DiForti, Marta, Díaz-Caneja, CovadongaM., MaríaDíaz-Zuluaga, Ana, DuPlessis, Stefan, Duran, FabioL.S., Fittipaldi, Sol, Fornito, Alex, Freimer, NelsonB., Gadelha, Ary, Gama, ClarissaS., Garani, Ranjini, Garcia-Rizo, Clemente, GonzalezCampo, Cecilia, Gonzalez-Valderrama, Alfonso, Guinjoan, Salvador, Holla, Bharath, Ibañez, Agustín, Ivanovic, Daniza, Jackowski, Andrea, Leon-Ortiz, Pablo, Lochner, Christine, López-Jaramillo, Carlos, Luckhoff, Hilmar, Massuda, Raffael, McGuire, Philip, Miyata, Jun, Mizrahi, Romina, Murray, Robin, Ozerdem, Aysegul, Pan, PedroM., Parellada, Mara, Phahladira, Lebogan, Ramirez-Mahaluf, JuanP., Reckziegel, Ramiro, ReisMarques, Tiago, Reyes-Madrigal, Francisco, Roos, Annerine, Rosa, Pedro, Salum, Giovanni, Scheffler, Freda, Schumann, Gunter, Serpa, Mauricio, Stein, DanJ., Tepper, Angeles, Tiego, Jeggan, Ueno, Tsukasa, Undurraga, Juan, Undurraga, EduardoA., Valdes-Sosa, Pedro, Valli, Isabel, Villarreal, Mirta, Winton-Brown, TobyT., Yalin, Nefize, Zamorano, Francisco, Zanetti, MarcusV., cVEDA, Winkler, AndersonM., Pine, DanielS., Evans-Lacko, Sara, and Crossley, NicolasA.
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GENDER INEQUALITY ,STRUCTURAL BRAIN MRI ,SEX DIFFERENCES - Abstract
Gender inequality across the world has been associated with a higher risk to mental health problems and lower academic achievement in women compared to men. We also know that the brain is shaped by nurturing and adverse socio-environmental experiences. Therefore, unequal exposure to harsher conditions for women compared to men in gender-unequal countries might be reflected in differences in their brain structure, and this could be the neural mechanism partly explaining women’s worse outcomes in gender-unequal countries. We examined this through a random-effects meta-analysis on cortical thickness and surface area differences between adult healthy men and women, including a meta-regression in which country-level gender inequality acted as an explanatory variable for the observed differences. A total of 139 samples from 29 different countries, totaling 7, 876 MRI scans, were included. Thickness of the right hemisphere, and particularly the right caudal anterior cingulate, right medial orbitofrontal, and left lateral occipital cortex, presented no differences or even thicker regional cortices in women compared to men in gender-equal countries, reversing to thinner cortices in countries with greater gender inequality. These results point to the potentially hazardous effect of gender inequality on women’s brains and provide initial evidence for neuroscience-informed policies for gender equality., 男女間の不平等と脳の性差 --男女間の不平等は脳構造の性差と関連する--. 京都大学プレスリリース. 2023-05-10.
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- 2023
19. Volume of subcortical brain regions in social anxiety disorder: mega-analytic results from 37 samples in the ENIGMA-Anxiety Working Group
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UCL - SSH/IPSY - Psychological Sciences Research Institute, UCL - SSS/IONS/NEUR - Clinical Neuroscience, Groenewold, Nynke A., Bas-Hoogendam, Janna Marie, Amod, Alyssa R., Laansma, Max A., Van Velzen, Laura S., Aghajani, Moji, Hilbert, Kevin, Oh, Hyuntaek, Salas, Ramiro, Jackowski, Andrea P., Pan, Pedro M., Salum, Giovanni A., Blair, James R., Blair, Karina S., Hirsch, Joy, Pantazatos, Spiro P., Schneier, Franklin R., Talati, Ardesheer, Roelofs, Karin, Volman, Inge, Blanco-Hinojo, Laura, Cardoner, Narcís, Pujol, Jesus, Beesdo-Baum, Katja, Ching, Christopher R. K., Thomopoulos, Sophia I., Jansen, Andreas, Kircher, Tilo, Krug, Axel, Nenadić, Igor, Stein, Frederike, Dannlowski, Udo, Grotegerd, Dominik, Lemke, Hannah, Meinert, Susanne, Winter, Alexandra, Erb, Michael, Kreifelts, Benjamin, Gong, Qiyong, Lui, Su, Zhu, Fei, Mwangi, Benson, Soares, Jair C., Wu, Mon-Ju, Bayram, Ali, Canli, Mesut, Tükel, Raşit, Westenberg, P. Michiel, Heeren, Alexandre, Cremers, Henk R., Hofmann, David, Straube, Thomas, Doruyter, Alexander G. G., Lochner, Christine, Peterburs, Jutta, Van Tol, Marie-José, Gur, Raquel E., Kaczkurkin, Antonia N., Larsen, Bart, Satterthwaite, Theodore D., Filippi, Courtney A., Gold, Andrea L., Harrewijn, Anita, Zugman, André, Bülow, Robin, Grabe, Hans J., Völzke, Henry, Wittfeld, Katharina, Böhnlein, Joscha, Dohm, Katharina, Kugel, Harald, Schrammen, Elisabeth, Zwanzger, Peter, Leehr, Elisabeth J., Sindermann, Lisa, Ball, Tali M., Fonzo, Gregory A., Paulus, Martin P., Simmons, Alan, Stein, Murray B., Klumpp, Heide, Phan, K. Luan, Furmark, Tomas, Månsson, Kristoffer N. T., Manzouri, Amirhossein, Avery, Suzanne N., Blackford, Jennifer Urbano, Clauss, Jacqueline A., Feola, Brandee, Harper, Jennifer C., Sylvester, Chad M., Lueken, Ulrike, Veltman, Dick J., Winkler, Anderson M., Jahanshad, Neda, Pine, Daniel S., Thompson, Paul M., Stein, Dan J., Van der Wee, Nic J. A., UCL - SSH/IPSY - Psychological Sciences Research Institute, UCL - SSS/IONS/NEUR - Clinical Neuroscience, Groenewold, Nynke A., Bas-Hoogendam, Janna Marie, Amod, Alyssa R., Laansma, Max A., Van Velzen, Laura S., Aghajani, Moji, Hilbert, Kevin, Oh, Hyuntaek, Salas, Ramiro, Jackowski, Andrea P., Pan, Pedro M., Salum, Giovanni A., Blair, James R., Blair, Karina S., Hirsch, Joy, Pantazatos, Spiro P., Schneier, Franklin R., Talati, Ardesheer, Roelofs, Karin, Volman, Inge, Blanco-Hinojo, Laura, Cardoner, Narcís, Pujol, Jesus, Beesdo-Baum, Katja, Ching, Christopher R. K., Thomopoulos, Sophia I., Jansen, Andreas, Kircher, Tilo, Krug, Axel, Nenadić, Igor, Stein, Frederike, Dannlowski, Udo, Grotegerd, Dominik, Lemke, Hannah, Meinert, Susanne, Winter, Alexandra, Erb, Michael, Kreifelts, Benjamin, Gong, Qiyong, Lui, Su, Zhu, Fei, Mwangi, Benson, Soares, Jair C., Wu, Mon-Ju, Bayram, Ali, Canli, Mesut, Tükel, Raşit, Westenberg, P. Michiel, Heeren, Alexandre, Cremers, Henk R., Hofmann, David, Straube, Thomas, Doruyter, Alexander G. G., Lochner, Christine, Peterburs, Jutta, Van Tol, Marie-José, Gur, Raquel E., Kaczkurkin, Antonia N., Larsen, Bart, Satterthwaite, Theodore D., Filippi, Courtney A., Gold, Andrea L., Harrewijn, Anita, Zugman, André, Bülow, Robin, Grabe, Hans J., Völzke, Henry, Wittfeld, Katharina, Böhnlein, Joscha, Dohm, Katharina, Kugel, Harald, Schrammen, Elisabeth, Zwanzger, Peter, Leehr, Elisabeth J., Sindermann, Lisa, Ball, Tali M., Fonzo, Gregory A., Paulus, Martin P., Simmons, Alan, Stein, Murray B., Klumpp, Heide, Phan, K. Luan, Furmark, Tomas, Månsson, Kristoffer N. T., Manzouri, Amirhossein, Avery, Suzanne N., Blackford, Jennifer Urbano, Clauss, Jacqueline A., Feola, Brandee, Harper, Jennifer C., Sylvester, Chad M., Lueken, Ulrike, Veltman, Dick J., Winkler, Anderson M., Jahanshad, Neda, Pine, Daniel S., Thompson, Paul M., Stein, Dan J., and Van der Wee, Nic J. A.
- Abstract
There is limited convergence in neuroimaging investigations into volumes of subcortical brain regions in social anxiety disorder (SAD). The inconsistent findings may arise from variations in methodological approaches across studies, including sample selection based on age and clinical characteristics. The ENIGMA-Anxiety Working Group initiated a global mega-analysis to determine whether differences in subcortical volumes can be detected in adults and adolescents with SAD relative to healthy controls. Volumetric data from 37 international samples with 1115 SAD patients and 2775 controls were obtained from ENIGMA-standardized protocols for image segmentation and quality assurance. Linear mixed-effects analyses were adjusted for comparisons across seven subcortical regions in each hemisphere using family-wise error (FWE)-correction. Mixed-effects d effect sizes were calculated. In the full sample, SAD patients showed smaller bilateral putamen volume than controls (left: d = −0.077, pFWE = 0.037; right: d = −0.104, pFWE = 0.001), and a significant interaction between SAD and age was found for the left putamen (r = −0.034, pFWE = 0.045). Smaller bilateral putamen volumes (left: d = −0.141, pFWE < 0.001; right: d = −0.158, pFWE < 0.001) and larger bilateral pallidum volumes (left: d = 0.129, pFWE = 0.006; right: d = 0.099, pFWE = 0.046) were detected in adult SAD patients relative to controls, but no volumetric differences were apparent in adolescent SAD patients relative to controls. Comorbid anxiety disorders and age of SAD onset were additional determinants of SAD-related volumetric differences in subcortical regions. To conclude, subtle volumetric alterations in subcortical regions in SAD were detected. Heterogeneity in age and clinical characteristics may partly explain inconsistencies in previous findings. The association between alterations in subcortical volumes and SAD illness progression deserves further investigation, especially from adolescence into adulthood.
- Published
- 2023
20. Volume of subcortical brain regions in social anxiety disorder : mega-analytic results from 37 samples in the ENIGMA-Anxiety Working Group
- Author
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Groenewold, Nynke A., Bas-Hoogendam, Janna Marie, Amod, Alyssa R., Laansma, Max A., Van Velzen, Laura S., Aghajani, Moji, Hilbert, Kevin, Oh, Hyuntaek, Salas, Ramiro, Jackowski, Andrea P., Pan, Pedro M., Salum, Giovanni A., Blair, James R., Blair, Karina S., Hirsch, Joy, Pantazatos, Spiro P., Schneier, Franklin R., Talati, Ardesheer, Roelofs, Karin, Volman, Inge, Blanco-Hinojo, Laura, Cardoner, Narcís, Pujol, Jesus, Beesdo-Baum, Katja, Ching, Christopher R. K., Thomopoulos, Sophia I., Jansen, Andreas, Kircher, Tilo, Krug, Axel, Nenadić, Igor, Stein, Frederike, Dannlowski, Udo, Grotegerd, Dominik, Lemke, Hannah, Meinert, Susanne, Winter, Alexandra, Erb, Michael, Kreifelts, Benjamin, Gong, Qiyong, Lui, Su, Zhu, Fei, Mwangi, Benson, Soares, Jair C., Wu, Mon-Ju, Bayram, Ali, Canli, Mesut, Tükel, Raşit, Westenberg, P. Michiel, Heeren, Alexandre, Cremers, Henk R., Hofmann, David, Straube, Thomas, Doruyter, Alexander G. G., Lochner, Christine, Peterburs, Jutta, Van Tol, Marie-José, Gur, Raquel E., Kaczkurkin, Antonia N., Larsen, Bart, Satterthwaite, Theodore D., Filippi, Courtney A., Gold, Andrea L., Harrewijn, Anita, Zugman, André, Bülow, Robin, Grabe, Hans J., Völzke, Henry, Wittfeld, Katharina, Böhnlein, Joscha, Dohm, Katharina, Kugel, Harald, Schrammen, Elisabeth, Zwanzger, Peter, Leehr, Elisabeth J., Sindermann, Lisa, Ball, Tali M., Fonzo, Gregory A., Paulus, Martin P., Simmons, Alan, Stein, Murray B., Klumpp, Heide, Phan, K. Luan, Furmark, Tomas, Månsson, Kristoffer N. T., Manzouri, Amirhossein, Avery, Suzanne N., Blackford, Jennifer Urbano, Clauss, Jacqueline A., Feola, Brandee, Harper, Jennifer C., Sylvester, Chad M., Lueken, Ulrike, Veltman, Dick J., Winkler, Anderson M., Jahanshad, Neda, Pine, Daniel S., Thompson, Paul M., Stein, Dan J., Van der Wee, Nic J. A., Groenewold, Nynke A., Bas-Hoogendam, Janna Marie, Amod, Alyssa R., Laansma, Max A., Van Velzen, Laura S., Aghajani, Moji, Hilbert, Kevin, Oh, Hyuntaek, Salas, Ramiro, Jackowski, Andrea P., Pan, Pedro M., Salum, Giovanni A., Blair, James R., Blair, Karina S., Hirsch, Joy, Pantazatos, Spiro P., Schneier, Franklin R., Talati, Ardesheer, Roelofs, Karin, Volman, Inge, Blanco-Hinojo, Laura, Cardoner, Narcís, Pujol, Jesus, Beesdo-Baum, Katja, Ching, Christopher R. K., Thomopoulos, Sophia I., Jansen, Andreas, Kircher, Tilo, Krug, Axel, Nenadić, Igor, Stein, Frederike, Dannlowski, Udo, Grotegerd, Dominik, Lemke, Hannah, Meinert, Susanne, Winter, Alexandra, Erb, Michael, Kreifelts, Benjamin, Gong, Qiyong, Lui, Su, Zhu, Fei, Mwangi, Benson, Soares, Jair C., Wu, Mon-Ju, Bayram, Ali, Canli, Mesut, Tükel, Raşit, Westenberg, P. Michiel, Heeren, Alexandre, Cremers, Henk R., Hofmann, David, Straube, Thomas, Doruyter, Alexander G. G., Lochner, Christine, Peterburs, Jutta, Van Tol, Marie-José, Gur, Raquel E., Kaczkurkin, Antonia N., Larsen, Bart, Satterthwaite, Theodore D., Filippi, Courtney A., Gold, Andrea L., Harrewijn, Anita, Zugman, André, Bülow, Robin, Grabe, Hans J., Völzke, Henry, Wittfeld, Katharina, Böhnlein, Joscha, Dohm, Katharina, Kugel, Harald, Schrammen, Elisabeth, Zwanzger, Peter, Leehr, Elisabeth J., Sindermann, Lisa, Ball, Tali M., Fonzo, Gregory A., Paulus, Martin P., Simmons, Alan, Stein, Murray B., Klumpp, Heide, Phan, K. Luan, Furmark, Tomas, Månsson, Kristoffer N. T., Manzouri, Amirhossein, Avery, Suzanne N., Blackford, Jennifer Urbano, Clauss, Jacqueline A., Feola, Brandee, Harper, Jennifer C., Sylvester, Chad M., Lueken, Ulrike, Veltman, Dick J., Winkler, Anderson M., Jahanshad, Neda, Pine, Daniel S., Thompson, Paul M., Stein, Dan J., and Van der Wee, Nic J. A.
- Abstract
There is limited convergence in neuroimaging investigations into volumes of subcortical brain regions in social anxiety disorder (SAD). The inconsistent findings may arise from variations in methodological approaches across studies, including sample selection based on age and clinical characteristics. The ENIGMA-Anxiety Working Group initiated a global mega-analysis to determine whether differences in subcortical volumes can be detected in adults and adolescents with SAD relative to healthy controls. Volumetric data from 37 international samples with 1115 SAD patients and 2775 controls were obtained from ENIGMA-standardized protocols for image segmentation and quality assurance. Linear mixed-effects analyses were adjusted for comparisons across seven subcortical regions in each hemisphere using family-wise error (FWE)-correction. Mixed-effects d effect sizes were calculated. In the full sample, SAD patients showed smaller bilateral putamen volume than controls (left: d = −0.077, pFWE = 0.037; right: d = −0.104, pFWE = 0.001), and a significant interaction between SAD and age was found for the left putamen (r = −0.034, pFWE = 0.045). Smaller bilateral putamen volumes (left: d = −0.141, pFWE < 0.001; right: d = −0.158, pFWE < 0.001) and larger bilateral pallidum volumes (left: d = 0.129, pFWE = 0.006; right: d = 0.099, pFWE = 0.046) were detected in adult SAD patients relative to controls, but no volumetric differences were apparent in adolescent SAD patients relative to controls. Comorbid anxiety disorders and age of SAD onset were additional determinants of SAD-related volumetric differences in subcortical regions. To conclude, subtle volumetric alterations in subcortical regions in SAD were detected. Heterogeneity in age and clinical characteristics may partly explain inconsistencies in previous findings. The association between alterations in subcortical volumes and SAD illness progression deserves further investigation, especially from adolescence into adul
- Published
- 2023
- Full Text
- View/download PDF
21. Volume of subcortical brain regions in social anxiety disorder: mega-analytic results from 37 samples in the ENIGMA-Anxiety Working Group
- Author
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Groenewold, Nynke A, Bas-Hoogendam, Janna Marie, Amod, Alyssa R, Laansma, Max A, Van Velzen, Laura S, Aghajani, Moji, Hilbert, Kevin, Oh, Hyuntaek, Salas, Ramiro, Jackowski, Andrea P, Pan, Pedro M, Salum, Giovanni A, Blair, James R, Blair, Karina S, Hirsch, Joy, Pantazatos, Spiro P, Schneier, Franklin R, Talati, Ardesheer, Roelofs, Karin, Volman, Inge, Blanco-Hinojo, Laura, Cardoner, Narcís, Pujol, Jesus, Beesdo-Baum, Katja, Ching, Christopher R K, Thomopoulos, Sophia I, Jansen, Andreas, Kircher, Tilo, Krug, Axel, Nenadić, Igor, Stein, Frederike, Dannlowski, Udo, Grotegerd, Dominik, Lemke, Hannah, Meinert, Susanne, Winter, Alexandra, Erb, Michael, Kreifelts, Benjamin, Gong, Qiyong, Lui, Su, Zhu, Fei, Mwangi, Benson, Soares, Jair C, Wu, Mon-Ju, Bayram, Ali, Canli, Mesut, Tükel, Raşit, Westenberg, P Michiel, Heeren, Alexandre, Cremers, Henk R, Hofmann, David, Straube, Thomas, Doruyter, Alexander G G, Lochner, Christine, Peterburs, Jutta, Van Tol, Marie-José, Gur, Raquel E, Kaczkurkin, Antonia N, Larsen, Bart, Satterthwaite, Theodore D, Filippi, Courtney A, Gold, Andrea L, Harrewijn, Anita, Zugman, André, Bülow, Robin, Grabe, Hans J, Völzke, Henry, Wittfeld, Katharina, Böhnlein, Joscha, Dohm, Katharina, Kugel, Harald, Schrammen, Elisabeth, Zwanzger, Peter, Leehr, Elisabeth J, Sindermann, Lisa, Ball, Tali M, Fonzo, Gregory A, Paulus, Martin P, Simmons, Alan, Stein, Murray B, Klumpp, Heide, Phan, K Luan, Furmark, Tomas, Månsson, Kristoffer N T, Manzouri, Amirhossein, Avery, Suzanne N, Blackford, Jennifer Urbano, Clauss, Jacqueline A, Feola, Brandee, Harper, Jennifer C, Sylvester, Chad M, Lueken, Ulrike, Veltman, Dick J, Winkler, Anderson M, Jahanshad, Neda, Pine, Daniel S, Thompson, Paul M, Stein, Dan J, Van der Wee, Nic J A, Groenewold, Nynke A, Bas-Hoogendam, Janna Marie, Amod, Alyssa R, Laansma, Max A, Van Velzen, Laura S, Aghajani, Moji, Hilbert, Kevin, Oh, Hyuntaek, Salas, Ramiro, Jackowski, Andrea P, Pan, Pedro M, Salum, Giovanni A, Blair, James R, Blair, Karina S, Hirsch, Joy, Pantazatos, Spiro P, Schneier, Franklin R, Talati, Ardesheer, Roelofs, Karin, Volman, Inge, Blanco-Hinojo, Laura, Cardoner, Narcís, Pujol, Jesus, Beesdo-Baum, Katja, Ching, Christopher R K, Thomopoulos, Sophia I, Jansen, Andreas, Kircher, Tilo, Krug, Axel, Nenadić, Igor, Stein, Frederike, Dannlowski, Udo, Grotegerd, Dominik, Lemke, Hannah, Meinert, Susanne, Winter, Alexandra, Erb, Michael, Kreifelts, Benjamin, Gong, Qiyong, Lui, Su, Zhu, Fei, Mwangi, Benson, Soares, Jair C, Wu, Mon-Ju, Bayram, Ali, Canli, Mesut, Tükel, Raşit, Westenberg, P Michiel, Heeren, Alexandre, Cremers, Henk R, Hofmann, David, Straube, Thomas, Doruyter, Alexander G G, Lochner, Christine, Peterburs, Jutta, Van Tol, Marie-José, Gur, Raquel E, Kaczkurkin, Antonia N, Larsen, Bart, Satterthwaite, Theodore D, Filippi, Courtney A, Gold, Andrea L, Harrewijn, Anita, Zugman, André, Bülow, Robin, Grabe, Hans J, Völzke, Henry, Wittfeld, Katharina, Böhnlein, Joscha, Dohm, Katharina, Kugel, Harald, Schrammen, Elisabeth, Zwanzger, Peter, Leehr, Elisabeth J, Sindermann, Lisa, Ball, Tali M, Fonzo, Gregory A, Paulus, Martin P, Simmons, Alan, Stein, Murray B, Klumpp, Heide, Phan, K Luan, Furmark, Tomas, Månsson, Kristoffer N T, Manzouri, Amirhossein, Avery, Suzanne N, Blackford, Jennifer Urbano, Clauss, Jacqueline A, Feola, Brandee, Harper, Jennifer C, Sylvester, Chad M, Lueken, Ulrike, Veltman, Dick J, Winkler, Anderson M, Jahanshad, Neda, Pine, Daniel S, Thompson, Paul M, Stein, Dan J, and Van der Wee, Nic J A
- Abstract
There is limited convergence in neuroimaging investigations into volumes of subcortical brain regions in social anxiety disorder (SAD). The inconsistent findings may arise from variations in methodological approaches across studies, including sample selection based on age and clinical characteristics. The ENIGMA-Anxiety Working Group initiated a global mega-analysis to determine whether differences in subcortical volumes can be detected in adults and adolescents with SAD relative to healthy controls. Volumetric data from 37 international samples with 1115 SAD patients and 2775 controls were obtained from ENIGMA-standardized protocols for image segmentation and quality assurance. Linear mixed-effects analyses were adjusted for comparisons across seven subcortical regions in each hemisphere using family-wise error (FWE)-correction. Mixed-effects d effect sizes were calculated. In the full sample, SAD patients showed smaller bilateral putamen volume than controls (left: d = -0.077, p FWE = 0.037; right: d = -0.104, p FWE = 0.001), and a significant interaction between SAD and age was found for the left putamen (r = -0.034, p FWE = 0.045). Smaller bilateral putamen volumes (left: d = -0.141, p FWE < 0.001; right: d = -0.158, p FWE < 0.001) and larger bilateral pallidum volumes (left: d = 0.129, p FWE = 0.006; right: d = 0.099, p FWE = 0.046) were detected in adult SAD patients relative to controls, but no volumetric differences were apparent in adolescent SAD patients relative to controls. Comorbid anxiety disorders and age of SAD onset were additional determinants of SAD-related volumetric differences in subcortical regions. To conclude, subtle volumetric alterations in subcortical regions in SAD were detected. Heterogeneity in age and clinical characteristics may partly explain inconsistencies in previous findings. The association between alterations in subcortical volumes and SAD illness progression deserves further investigation, especially from adol
- Published
- 2023
22. Peripheral immuno-inflammatory abnormalities in ultra-high risk of developing psychosis
- Author
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Zeni-Graiff, Maiara, Rizzo, Lucas B., Mansur, Rodrigo B., Maurya, Pawan K., Sethi, Sumit, Cunha, Graccielle R., Asevedo, Elson, Pan, Pedro, Zugman, André, Yamagata, Ana S., Higuchi, Cinthia, Bressan, Rodrigo A., Gadelha, Ary, and Brietzke, Elisa
- Published
- 2016
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23. Association of serum interleukin-6 with mental health problems in children exposed to perinatal complications and social disadvantage
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Mansur, Rodrigo B., Cunha, Graccielle R., Asevedo, Elson, Zugman, André, Rizzo, Lucas B., Grassi-Oliveira, Rodrigo, Levandowski, Mateus L., Gadelha, Ary, Pan, Pedro M., Teixeira, Antônio L., McIntyre, Roger S., Mari, Jair J., Rohde, Luís A., Miguel, Eurípedes C., Bressan, Rodrigo A., and Brietzke, Elisa
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- 2016
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24. Structural covariance in schizophrenia and first-episode psychosis: An approach based on graph analysis
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Zugman, André, Assunção, Idaiane, Vieira, Gilson, Gadelha, Ary, White, Thomas P., Oliveira, Pedro Paulo M., Noto, Cristiano, Crossley, Nicolas, Mcguire, Philip, Cordeiro, Quirino, Belangero, Sintia I.O., Bressan, Rodrigo A., Jackowski, Andrea P., and Sato, João Ricardo
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- 2015
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25. Can neuroimaging be used to predict the onset of psychosis?
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McGuire, Philip, Sato, Joao R, Mechelli, Andrea, Jackowski, Andrea, Bressan, Rodrigo A, and Zugman, Andre
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- 2015
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26. Deviations from a typical development of the cerebellum in youth are associated with psychopathology, executive functions and educational outcomes.
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Borges, Marina S., Hoffmann, Maurício S., Simioni, André, Axelrud, Luiza K., Teixeira, Danielle S., Zugman, André, Jackowski, Andrea, Pan, Pedro M., Bressan, Rodrigo A., Parker, Nadine, Germann, Jurgen, Bado, Patrícia P., Satterthwaite, Theodore D., Milham, Michael P., Chakravarty, M. Mallar, Paim Rohde, Luis Augusto, Constantino Miguel, Eurípedes, Paus, Tomas, and Salum, Giovanni A.
- Subjects
EXECUTIVE function ,CROSS-sectional method ,MENTAL health ,COGNITION ,CEREBELLUM ,ACADEMIC achievement ,PATHOLOGICAL psychology ,FACTOR analysis ,RESEARCH funding ,EDUCATIONAL attainment ,LONGITUDINAL method - Abstract
Background: Understanding deviations from typical brain development is a promising approach to comprehend pathophysiology in childhood and adolescence. We investigated if cerebellar volumes different than expected for age and sex could predict psychopathology, executive functions and academic achievement. Methods: Children and adolescents aged 6–17 years from the Brazilian High-Risk Cohort Study for Mental Conditions had their cerebellar volume estimated using Multiple Automatically Generated Templates from T1-weighted images at baseline (n = 677) and at 3-year follow-up (n = 447). Outcomes were assessed using the Child Behavior Checklist and standardized measures of executive functions and school achievement. Models of typically developing cerebellum were based on a subsample not exposed to risk factors and without mental-health conditions (n = 216). Deviations from this model were constructed for the remaining individuals (n = 461) and standardized variation from age and sex trajectory model was used to predict outcomes in cross-sectional, longitudinal and mediation analyses. Results: Cerebellar volumes higher than expected for age and sex were associated with lower externalizing specific factor and higher executive functions. In a longitudinal analysis, deviations from typical development at baseline predicted inhibitory control at follow-up, and cerebellar deviation changes from baseline to follow-up predicted changes in reading and writing abilities. The association between deviations in cerebellar volume and academic achievement was mediated by inhibitory control. Conclusions: Deviations in the cerebellar typical development are associated with outcomes in youth that have long-lasting consequences. This study highlights both the potential of typical developing models and the important role of the cerebellum in mental health, cognition and education. [ABSTRACT FROM AUTHOR]
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- 2023
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27. Serum brain-derived neurotrophic factor and cortical thickness are differently related in patients with schizophrenia and controls
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Zugman, Andre, Pedrini, Mariana, Gadelha, Ary, Kempton, Matthew J, Noto, Cristiano S., Mansur, Rodrigo B., Santoro, Marcos L., Gama, Clarissa S., Bressan, Rodrigo A., McGuire, Philip, Jackowski, Andrea P., and Brietzke, Elisa
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- 2015
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28. Brain-Based Classification of Youth with Anxiety Disorders: an ENIGMA-ANXIETY Transdiagnostic Examination using Machine Learning
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Bruin, Willem B., primary, Zhutovsky, Paul, additional, van Wingen, Guido, additional, Bas-Hoogendam, Janna Marie, additional, Groenewold, Nynke A., additional, Hilbert, Kevin, additional, Winkler, Anderson M., additional, Zugman, André, additional, Agosta, Federica, additional, Åhs, Fredrik, additional, Andreescu, Carmen, additional, Antonacci, Chase, additional, Asami, Takeshi, additional, Assaf, Michal, additional, Barber, Jacques, additional, Bauer, Jochen, additional, Bavdekar, Shreya, additional, Beesdo-Baum, Katja, additional, Benedetti, Francesco, additional, Bernstein, Rachel, additional, Björkstrand, Johannes, additional, Blair, Robert, additional, Blair, Karina S., additional, Blanco-Hinojo, Laura, additional, Böhnlein, Joscha, additional, Brambilla, Paolo, additional, Bressan, Rodrigo, additional, Breuer, Fabian, additional, Cano, Marta, additional, Canu, Elisa, additional, Cardinale, Elise M, additional, Cardoner, Narcís, additional, Cividini, Camilla, additional, Cremers, Henk, additional, Dannlowski, Udo, additional, Diefenbach, Gretchen J., additional, Domschke, Katharina, additional, Doruyter, Alexander, additional, Dresler, Thomas, additional, Erhardt, Angelika, additional, Filippi, Massimo, additional, Fonzo, Gregory, additional, Freitag, Gabrielle Felice, additional, Furmark, Tomas, additional, Ge, Tian, additional, Gerber, Andrew J., additional, Gosnell, Savannah, additional, Grabe, Hans J., additional, Grotegerd, Dominik, additional, Gur, Ruben C., additional, Gur, Raquel E., additional, Hamm, Alfons O., additional, Han, Laura K. M., additional, Harper, Jennifer, additional, Harrewijn, Anita, additional, Heeren, Alexandre, additional, Hoffman, David, additional, Jackowski, Andrea P., additional, Jahanshad, Neda, additional, Jett, Laura, additional, Kaczkurkin, Antonia N., additional, Khosravi, Parmis, additional, Kingsley, Ellen, additional, Kircher, Tilo, additional, Kostić, Milutin, additional, Larsen, Bart, additional, Lee, Sang-Hyuk, additional, Leehr, Elisabeth, additional, Leibenluft, Ellen, additional, Lochner, Christine, additional, Lui, Su, additional, Maggioni, Eleonora, additional, Manfro, Gisele Gus, additional, Månsson, Kristoffer, additional, Marino, Claire, additional, Meeten, Frances, additional, Milrod, Barbara, additional, Munjiza, Ana, additional, Irungu, Benson, additional, Myers, Michael, additional, Neufang, Susanne, additional, Nielsen, Jared, additional, Ohrmann, Patricia, additional, Ottaviani, Cristina, additional, Paulus, Martin P, additional, Perino, Michael T., additional, Phan, K Luan, additional, Poletti, Sara, additional, Porta-Casteràs, Daniel, additional, Pujol, Jesus, additional, Reinecke, Andrea, additional, Ringlein, Grace, additional, Rjabtsenkov, Pavel, additional, Roelofs, Karin, additional, Salas, Ramiro, additional, Salum, Giovanni, additional, Satterthwaite, Theodore D., additional, Schrammen, Elisabeth, additional, Sindermann, Lisa, additional, Smoller, Jordan, additional, Soares, Jair, additional, Stark, Rudolf, additional, Stein, Frederike, additional, straube, thomas, additional, Straube, Benjamin, additional, Strawn, Jeffrey, additional, Suarez-Jimenez, Benjamin, additional, Sylvester, Chad M., additional, Talati, Ardesheer, additional, Thomopoulos, Sophia I, additional, Tükel, Raşit, additional, van Nieuwenhuizen, Helena, additional, Werwath, Katy E., additional, Wittfeld, Katharina, additional, Wright, Barry, additional, Wu, Mon-Ju, additional, Yang, Yunbo, additional, Zilverstand, Anna, additional, Zwanzger, Peter, additional, Blackford, Jennifer, additional, Avery, Suzanne, additional, Clauss, Jacqueline, additional, Lueken, Ulrike, additional, Thompson, Paul, additional, Pine, Daniel, additional, Stein, Dan J., additional, van der Wee, Nic, additional, Veltman, Dick, additional, and Aghajani, Moji, additional
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- 2022
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29. Perinatal complications, lipid peroxidation, and mental health problems in a large community pediatric sample
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Mansur, Rodrigo B., Cunha, Graccielle R., Asevedo, Elson, Zugman, André, Rios, Adiel C., Salum, Giovanni A., Pan, Pedro M., Gadelha, Ary, Levandowski, Mateus L., Belangero, Síntia I., Manfro, Gisele G., Stertz, Laura, Kauer-Sant’anna, Márcia, Miguel, Eurípedes C., Bressan, Rodrigo A., Mari, Jair J., Grassi-Oliveira, Rodrigo, and Brietzke, Elisa
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- 2017
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30. Age effects on the default mode and control networks in typically developing children
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Sato, João Ricardo, Salum, Giovanni Abrahão, Gadelha, Ary, Picon, Felipe Almeida, Pan, Pedro Mario, Vieira, Gilson, Zugman, André, Hoexter, Marcelo Queiroz, Anés, Mauricio, Moura, Luciana Monteiro, Gomes Del'Aquilla, Marco Antonio, Amaro, Edson, Junior, McGuire, Philip, Crossley, Nicolas, Lacerda, Acioly, Rohde, Luis Augusto, Miguel, Euripedes Constantino, Bressan, Rodrigo Affonseca, and Jackowski, Andrea Parolin
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- 2014
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31. Deviations from a typical development of the cerebellum in youth are associated with psychopathology, executive functions and educational outcomes
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Borges, Marina S., primary, Hoffmann, Maurício S., additional, Simioni, André, additional, Axelrud, Luiza K., additional, Teixeira, Danielle S., additional, Zugman, André, additional, Jackowski, Andrea, additional, Pan, Pedro M., additional, Bressan, Rodrigo A., additional, Parker, Nadine, additional, Germann, Jurgen, additional, Bado, Patrícia P., additional, Satterthwaite, Theodore D., additional, Milham, Michael P., additional, Chakravarty, M. Mallar, additional, Paim Rohde, Luis Augusto, additional, Constantino Miguel, Eurípedes, additional, Paus, Tomas, additional, and Salum, Giovanni A., additional
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- 2022
- Full Text
- View/download PDF
32. Structural Brain Correlates of Childhood Inhibited Temperament: An ENIGMA-Anxiety Mega-analysis
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Bas-Hoogendam, Janna Marie, primary, Bernstein, Rachel, additional, Benson, Brenda E., additional, Buss, Kristin A., additional, Gunther, Kelley E., additional, Pérez-Edgar, Koraly, additional, Salum, Giovanni A., additional, Jackowski, Andrea P., additional, Bressan, Rodrigo A., additional, Zugman, André, additional, Degnan, Kathryn A., additional, Filippi, Courtney A., additional, Fox, Nathan A., additional, Henderson, Heather A., additional, Tang, Alva, additional, Zeytinoglu, Selin, additional, Harrewijn, Anita, additional, Hillegers, Manon H.J., additional, White, Tonya, additional, van IJzendoorn, Marinus H., additional, Schwartz, Carl E., additional, Felicione, Julia M., additional, DeYoung, Kathryn A., additional, Shackman, Alexander J., additional, Smith, Jason F., additional, Tillman, Rachael M., additional, van den Berg, Yvonne H.M., additional, Cillessen, Antonius H.N., additional, Roelofs, Karin, additional, Tyborowska, Anna, additional, Hill, Shirley Y., additional, Battaglia, Marco, additional, Tettamanti, Marco, additional, Dougherty, Lea R., additional, Jin, Jingwen, additional, Klein, Daniel N., additional, Leung, Hoi-Chung, additional, Avery, Suzanne N., additional, Blackford, Jennifer Urbano, additional, Clauss, Jacqueline A., additional, Hayden, Elizabeth P., additional, Liu, Pan, additional, Vandermeer, Matthew R.J., additional, Goldsmith, H. Hill, additional, Planalp, Elizabeth M., additional, Nichols, Thomas E., additional, Thompson, Paul M., additional, Westenberg, P. Michiel, additional, van der Wee, Nic J.A., additional, Groenewold, Nynke A., additional, Stein, Dan J., additional, Winkler, Anderson M., additional, and Pine, Daniel S., additional
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- 2022
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- View/download PDF
33. Reduction of anterior cingulate in adults with urban violence- related PTSD
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Baldaçara, Leonardo, Zugman, André, Araújo, Célia, Cogo-Moreira, Hugo, Lacerda, Acioly Luiz Tavares, Schoedl, Aline, Pupo, Mariana, Mello, Marcelo Feijo, Andreoli, Sergio B., de Jesus Mari, Jair, Bressan, Rodrigo Affonseca, and Jackowski, Andrea Parolin
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- 2014
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34. Impact of peripheral levels of chemokines, BDNF and oxidative markers on cognition in individuals with schizophrenia
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Asevedo, Elson, Gadelha, Ary, Noto, Cristiano, Mansur, Rodrigo B., Zugman, André, Belangero, Síntia I.N., Berberian, Arthur A., Scarpato, Bruno S., Leclerc, Emilie, Teixeira, Antônio L., Gama, Clarissa S., Bressan, Rodrigo A., and Brietzke, Elisa
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- 2013
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35. Reduced dorso-lateral prefrontal cortex in treatment resistant schizophrenia
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Zugman, André, Gadelha, Ary, Assunção, Idaiane, Sato, João, Ota, Vanessa K., Rocha, Deyvis L., Mari, Jair J., Belangero, Sintia I., Bressan, Rodrigo A., Brietzke, Elisa, and Jackowski, Andrea P.
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- 2013
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- View/download PDF
36. Is there a role for curcumin in the treatment of bipolar disorder?
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Brietzke, Elisa, Mansur, Rodrigo B., Zugman, Andre, Carvalho, André F., Macêdo, Danielle S., Cha, Danielle S., Abílio, Vanessa C., and McIntyre, Roger S.
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- 2013
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37. Structural brain correlates of childhood inhibited temperament:An ENIGMA-anxiety mega-analysis
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Bas-Hoogendam, Janna Marie, Bernstein, Rachel, Benson, Brenda E., Buss, Kristin A., Gunther, Kelley E., Pérez-Edgar, Koraly, Salum, Giovanni A., Jackowski, Andrea P., Bressan, Rodrigo A., Zugman, André, Degnan, Kathryn A., Filippi, Courtney A., Fox, Nathan A., Henderson, Heather A., Tang, Alva, Zeytinoglu, Selin, Harrewijn, Anita, Hillegers, Manon H.J., White, Tonya, van IJzendoorn, Marinus H., Schwartz, Carl E., Felicione, Julia M., DeYoung, Kathryn A., Shackman, Alexander J., Smith, Jason F., Tillman, Rachael M., van den Berg, Yvonne H.M., Cillessen, Antonius H.N., Roelofs, Karin, Tyborowska, Anna, Hill, Shirley Y., Battaglia, Marco, Tettamanti, Marco, Dougherty, Lea R., Jin, Jingwen, Klein, Daniel N., Leung, Hoi Chung, Avery, Suzanne N., Blackford, Jennifer Urbano, Clauss, Jacqueline A., Hayden, Elizabeth P., Liu, Pan, Vandermeer, Matthew R.J., Goldsmith, H. Hill, Planalp, Elizabeth M., Nichols, Thomas E., Thompson, Paul M., Westenberg, P. Michiel, van der Wee, Nic J.A., Groenewold, Nynke A., Bas-Hoogendam, Janna Marie, Bernstein, Rachel, Benson, Brenda E., Buss, Kristin A., Gunther, Kelley E., Pérez-Edgar, Koraly, Salum, Giovanni A., Jackowski, Andrea P., Bressan, Rodrigo A., Zugman, André, Degnan, Kathryn A., Filippi, Courtney A., Fox, Nathan A., Henderson, Heather A., Tang, Alva, Zeytinoglu, Selin, Harrewijn, Anita, Hillegers, Manon H.J., White, Tonya, van IJzendoorn, Marinus H., Schwartz, Carl E., Felicione, Julia M., DeYoung, Kathryn A., Shackman, Alexander J., Smith, Jason F., Tillman, Rachael M., van den Berg, Yvonne H.M., Cillessen, Antonius H.N., Roelofs, Karin, Tyborowska, Anna, Hill, Shirley Y., Battaglia, Marco, Tettamanti, Marco, Dougherty, Lea R., Jin, Jingwen, Klein, Daniel N., Leung, Hoi Chung, Avery, Suzanne N., Blackford, Jennifer Urbano, Clauss, Jacqueline A., Hayden, Elizabeth P., Liu, Pan, Vandermeer, Matthew R.J., Goldsmith, H. Hill, Planalp, Elizabeth M., Nichols, Thomas E., Thompson, Paul M., Westenberg, P. Michiel, van der Wee, Nic J.A., and Groenewold, Nynke A.
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- 2022
38. Structural Brain Correlates of Childhood Inhibited Temperament: An ENIGMA-Anxiety Mega-analysis
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Bas-Hoogendam, J, Bernstein, R, Benson, B, Buss, K, Gunther, K, Pérez-Edgar, K, Salum, G, Jackowski, A, Bressan, R, Zugman, A, Degnan, K, Filippi, C, Fox, N, Henderson, H, Tang, A, Zeytinoglu, S, Harrewijn, A, Hillegers, M, White, T, van IJzendoorn, M, Schwartz, C, Felicione, J, Deyoung, K, Shackman, A, Smith, J, Tillman, R, van den Berg, Y, Cillessen, A, Roelofs, K, Tyborowska, A, Hill, S, Battaglia, M, Tettamanti, M, Dougherty, L, Jin, J, Klein, D, Leung, H, Avery, S, Blackford, J, Clauss, J, Hayden, E, Liu, P, Vandermeer, M, Goldsmith, H, Planalp, E, Nichols, T, Thompson, P, Westenberg, P, van der Wee, N, Groenewold, N, Stein, D, Winkler, A, Pine, D, Bas-Hoogendam, Janna Marie, Bernstein, Rachel A., Benson, Brenda E., Buss, Kristin A., Gunther, Kelley E., Pérez-Edgar, Koraly, Salum, Giovanni A., Jackowski, Andrea, Bressan, Rodrigo A., Zugman, André, Degnan, Kathryn A., Filippi, Courtney A., Fox, Nathan A., Henderson, Heather A., Tang, Alva, Zeytinoglu, Selin, Harrewijn, Anita, Hillegers, Manon H. J., White, Tonya, van IJzendoorn, Marinus H., Schwartz, Carl E., Felicione, Julia M., DeYoung, Kathryn A., Shackman, Alexander J., Smith, Jason F., Tillman, Rachael, van den Berg, Yvonne H. M., Cillessen, Antonius H. N., Roelofs, Karin, Tyborowska, Anna, Hill, Shirley Y., Battaglia, Marco, Tettamanti, Marco, Dougherty, Lea R., Jin, Jingwen, Klein, Daniel N., Leung, Hoi-Chung, Avery, Suzanne N., Blackford, Jennifer Urbano, Clauss, Jacqueline A., Hayden, Elizabeth P., Liu, Pan, Vandermeer, Matthew R. J., Goldsmith, H. Hill, Planalp, Elizabeth M., Nichols, Thomas E., Thompson, Paul M., Westenberg, P. Michiel, van der Wee, Nic J. A., Groenewold, Nynke A., Stein, Dan J., Winkler, Anderson M., Pine, Daniel S., Bas-Hoogendam, J, Bernstein, R, Benson, B, Buss, K, Gunther, K, Pérez-Edgar, K, Salum, G, Jackowski, A, Bressan, R, Zugman, A, Degnan, K, Filippi, C, Fox, N, Henderson, H, Tang, A, Zeytinoglu, S, Harrewijn, A, Hillegers, M, White, T, van IJzendoorn, M, Schwartz, C, Felicione, J, Deyoung, K, Shackman, A, Smith, J, Tillman, R, van den Berg, Y, Cillessen, A, Roelofs, K, Tyborowska, A, Hill, S, Battaglia, M, Tettamanti, M, Dougherty, L, Jin, J, Klein, D, Leung, H, Avery, S, Blackford, J, Clauss, J, Hayden, E, Liu, P, Vandermeer, M, Goldsmith, H, Planalp, E, Nichols, T, Thompson, P, Westenberg, P, van der Wee, N, Groenewold, N, Stein, D, Winkler, A, Pine, D, Bas-Hoogendam, Janna Marie, Bernstein, Rachel A., Benson, Brenda E., Buss, Kristin A., Gunther, Kelley E., Pérez-Edgar, Koraly, Salum, Giovanni A., Jackowski, Andrea, Bressan, Rodrigo A., Zugman, André, Degnan, Kathryn A., Filippi, Courtney A., Fox, Nathan A., Henderson, Heather A., Tang, Alva, Zeytinoglu, Selin, Harrewijn, Anita, Hillegers, Manon H. J., White, Tonya, van IJzendoorn, Marinus H., Schwartz, Carl E., Felicione, Julia M., DeYoung, Kathryn A., Shackman, Alexander J., Smith, Jason F., Tillman, Rachael, van den Berg, Yvonne H. M., Cillessen, Antonius H. N., Roelofs, Karin, Tyborowska, Anna, Hill, Shirley Y., Battaglia, Marco, Tettamanti, Marco, Dougherty, Lea R., Jin, Jingwen, Klein, Daniel N., Leung, Hoi-Chung, Avery, Suzanne N., Blackford, Jennifer Urbano, Clauss, Jacqueline A., Hayden, Elizabeth P., Liu, Pan, Vandermeer, Matthew R. J., Goldsmith, H. Hill, Planalp, Elizabeth M., Nichols, Thomas E., Thompson, Paul M., Westenberg, P. Michiel, van der Wee, Nic J. A., Groenewold, Nynke A., Stein, Dan J., Winkler, Anderson M., and Pine, Daniel S.
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- 2022
39. Impact of Childhood Stress on Psychopathology
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Brietzke, Elisa, Sant’anna, Márcia Kauer, Jackowski, Andréa, Grassi-Oliveira, Rodrigo, Bucker, Joanna, Zugman, André, Mansur, Rodrigo Barbachan, and Bressan, Rodrigo Affonseca
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- 2012
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40. Mega-analysis methods in ENIGMA : the experience of the generalized anxiety disorder working group
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Zugman, André, Winkler, Anderson Marcelo, Salum Junior, Giovanni Abrahão, and Manfro, Gisele Gus
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Transtornos de ansiedade ,Metanálise ,Generalized anxiety disorder ,Meta-analyses ,Disseminação da informação ,Data sharing ,Neuroimaging ,Base de dados ,Neuroimagem ,Mega-analyses - Abstract
The ENIGMA group on Generalized Anxiety Disorder (ENIGMA-Anxiety/GAD) is part of a broader effort to investigate anxiety disorders using imaging and genetic data across multiple sites worldwide. The group is actively conducting a mega-analysis of a large number of brain structural scans. In this process, the group was confronted with many methodological challenges related to study planning and implementation, between-country transfer of subject-level data, quality control of a considerable amount of imaging data, and choices related to statistical methods and efficient use of resources. This report summarizes the background information and rationale for the various methodological decisions, as well as the approach taken to implement them. The goal is to document the approach and help guide other research groups working with large brain imaging data sets as they develop their own analytic pipelines for mega-analyses.
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- 2022
41. Default mode network maturation and psychopathology in children and adolescents
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Sato, João Ricardo, Salum, Giovanni Abrahão, Gadelha, Ary, Crossley, Nicolas, Vieira, Gilson, Manfro, Gisele Gus, Zugman, André, Picon, Felipe Almeida, Pan, Pedro Mario, Hoexter, Marcelo Queiroz, Anés, Mauricio, Moura, Luciana Monteiro, DelʼAquilla, Marco Antonio Gomes, Jr, Edson Amaro, McGuire, Philip, Lacerda, Acioly Luiz Tavares, Rohde, Luis Augusto, Miguel, Euripedes Constantino, Jackowski, Andrea Parolin, and Bressan, Rodrigo Affonseca
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- 2016
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42. Corrigendum to: Towards Precision Medicine in Psychosis: Benefits and Challenges of Multimodal Multicenter Studies-PSYSCAN: Translating Neuroimaging Findings From Research into Clinical Practice
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Tognin, Stefania, van Hell, Hendrika H, Merritt, Kate, Winter-van Rossum, Inge, Bossong, Matthijs G, Kempton, Matthew J, Modinos, Gemma, Fusar-Poli, Paolo, Mechelli, Andrea, Dazzan, Paola, Maat, Arija, de Haan, Lieuwe, Crespo-Facorro, Benedicto, Glenthøj, Birte, Lawrie, Stephen M, McDonald, Colm, Gruber, Oliver, van Amelsvoort, Therese, Arango, Celso, Kircher, Tilo, Nelson, Barnaby, Galderisi, Silvana, Bressan, Rodrigo, Kwon, Jun S, Weiser, Mark, Mizrahi, Romina, Sachs, Gabriele, Maatz, Anke, Kahn, René, McGuire, Phillip, McGuire, Philip, Kempton, Matthew, Gifford, George, Petros, Natalia, Antoniades, Mathilde, De Micheli, Andrea, Vieira, Sandra, Spencer, Tom J, Scarpazza, Cristina, Hird, Emily, Kahn, Rene, van Hell, Erika, Winter, Inge, Cahn, Wiepke, Schnack, Hugo, Siegmann, Dieuwke, Barkhof, Jana, Hendriks, Lotte, de Wit, Iris, Tordesillas-Gutierrez, Diana, Setien-Suero, Esther, Ayesa-Arriola, Rosa, Suarez-Pinilla, Paula, Ramirez-Bonilla, MariaLuz, Garcia-de la foz, Victor Ortiz, Erlang Sørensen, Mikkel, Tangmose, Karen, Schæbel, Helle, Broberg, Brian, Rostrup, Egill, Lawrie, Stephen, Hallahan, Brian, Cannon, Dara, McLoughlin, James, Finnegan, Martha, Deckers, Danny, Marcelis, Machteld, Vingerhoets, Claudia, Díaz-Caneja, Covadonga M, Ayora, Miriam, Janssen, Joost, Rodríguez-Jiménez, Roberto, Díaz-Marsá, Marina, Falkenberg, Irina, Bitsch, Florian, Berger, Philipp, Sommer, Jens, Raab, Kyeon, Jakobi, Babette, McGorry, Patrick, Amminger, Paul, McHugh, Meredith, Mucci, Armida, Bucci, Paola, Piegari, Giuseppe, Pietrafesa, Daria, Nicita, Alessia, Patriarca, Sara, Zugman, André, Gadelha, Ary, Rodrigues da Cunha, Graccielle, Soo Kwon, Jun, Kevin Cho, Kang I k, Young Lee, Tae, Kim, Minah, Bin Kwak, Yoo, Jeong Hwang, Wu, Kiang, Michael, Gerritsen, Cory, Maheandiran, Margaret, Ahmed, Sarah, Prce, Ivana, Lepock, Jenny, Willeit, Matthäus, Lenczowski, Marzena, Sauerzopf, Ullrich, Weidenauer, Ana, Furtner-Srajer, Julia, Kirschner, Matthias, Burrer, Achim, Stämpfli, Philipp, Huber, Naemi, Kaiser, Stefan, Kawohl, Wolfram, Brammer, Michael, Young, Jonathan, Bullmore, Edward, Morgan, Sarah, European Commission, University of Zurich, PSYSCAN Consortium, Tognin, Stefania, van Hell, Hendrika H, Merritt, Kate, Winter-van Rossum, Inge, Bossong, Matthijs G, Kempton, Matthew J, Modinos, Gemma, Fusar-Poli, Paolo, Mechelli, Andrea, Dazzan, Paola, Maat, Arija, de Haan, Lieuwe, Crespo-Facorro, Benedicto, Glenthøj, Birte, Lawrie, Stephen M, Mcdonald, Colm, Gruber, Oliver, van Amelsvoort, Therese, Arango, Celso, Kircher, Tilo, Nelson, Barnaby, Galderisi, Silvana, Bressan, Rodrigo, Kwon, Jun S, Weiser, Mark, Mizrahi, Romina, Sachs, Gabriele, Maatz, Anke, Kahn, René, Mcguire, Phillip, Mcguire, Philip, Kempton, Matthew, Gifford, George, Petros, Natalia, Antoniades, Mathilde, De Micheli, Andrea, Vieira, Sandra, Spencer, Tom J, Scarpazza, Cristina, Hird, Emily, Kahn, Rene, van Hell, Erika, Winter, Inge, Cahn, Wiepke, Schnack, Hugo, Siegmann, Dieuwke, Barkhof, Jana, Hendriks, Lotte, de Wit, Iri, Tordesillas-Gutierrez, Diana, Setien-Suero, Esther, Ayesa-Arriola, Rosa, Suarez-Pinilla, Paula, Ramirez-Bonilla, Marialuz, Garcia-de la foz, Victor Ortiz, Erlang Sørensen, Mikkel, Tangmose, Karen, Schæbel, Helle, Broberg, Brian, Rostrup, Egill, Lawrie, Stephen, Hallahan, Brian, Cannon, Dara, Mcloughlin, Jame, Finnegan, Martha, Deckers, Danny, Marcelis, Machteld, Vingerhoets, Claudia, Díaz-Caneja, Covadonga M, Ayora, Miriam, Janssen, Joost, Rodríguez-Jiménez, Roberto, Díaz-Marsá, Marina, Falkenberg, Irina, Bitsch, Florian, Berger, Philipp, Sommer, Jen, Raab, Kyeon, Jakobi, Babette, Mcgorry, Patrick, Amminger, Paul, Mchugh, Meredith, Mucci, Armida, Bucci, Paola, Piegari, Giuseppe, Pietrafesa, Daria, Nicita, Alessia, Patriarca, Sara, Zugman, André, Gadelha, Ary, Rodrigues da Cunha, Graccielle, Soo Kwon, Jun, Kevin Cho, Kang I k, Young Lee, Tae, Kim, Minah, Bin Kwak, Yoo, Jeong Hwang, Wu, Kiang, Michael, Gerritsen, Cory, Maheandiran, Margaret, Ahmed, Sarah, Prce, Ivana, Lepock, Jenny, Willeit, Matthäu, Lenczowski, Marzena, Sauerzopf, Ullrich, Weidenauer, Ana, Furtner-Srajer, Julia, Kirschner, Matthia, Burrer, Achim, Stämpfli, Philipp, Huber, Naemi, Kaiser, Stefan, Kawohl, Wolfram, Brammer, Michael, Young, Jonathan, Bullmore, Edward, Morgan, Sarah, Adult Psychiatry, ANS - Mood, Anxiety, Psychosis, Stress & Sleep, APH - Mental Health, RS: MHeNs - R2 - Mental Health, Psychiatrie & Neuropsychologie, and MUMC+: MA Med Staf Spec Psychiatrie (9)
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Research design ,MathematicsofComputing_GENERAL ,Disease ,psychosi ,DISEASE ,2738 Psychiatry and Mental Health ,0302 clinical medicine ,ultra-high-risk ,SCHIZOPHRENIA ,Multicenter Studies as Topic ,Longitudinal Studies ,Precision Medicine ,machine ,pattern-classification ,TheoryofComputation_GENERAL ,Cognition ,3. Good health ,Psychiatry and Mental health ,Research Design ,Schizophrenia ,First episode of psychosis ,PSYSCAN ,Clinical psychology ,MRI ,clinical high risk of psychosis ,first episode of psychosis ,machine learning ,neuroimaging ,prediction ,psychosis ,Psychosis ,onset ,610 Medicine & health ,Neuroimaging ,Clinical high risk of psychosis ,03 medical and health sciences ,1st-episode psychosis ,Machine learning ,medicine ,Humans ,clinical high risk of psychosi ,neuroanatomical abnormalities ,first episode of psychosi ,Protocol (science) ,reliability ,business.industry ,prediction models ,Precision medicine ,medicine.disease ,030227 psychiatry ,Psychotic Disorders ,10054 Clinic for Psychiatry, Psychotherapy, and Psychosomatics ,business ,Prediction ,030217 neurology & neurosurgery ,Regular Articles - Abstract
PSYSCAN Consortium., In the last 2 decades, several neuroimaging studies investigated brain abnormalities associated with the early stages of psychosis in the hope that these could aid the prediction of onset and clinical outcome. Despite advancements in the field, neuroimaging has yet to deliver. This is in part explained by the use of univariate analytical techniques, small samples and lack of statistical power, lack of external validation of potential biomarkers, and lack of integration of nonimaging measures (eg, genetic, clinical, cognitive data). PSYSCAN is an international, longitudinal, multicenter study on the early stages of psychosis which uses machine learning techniques to analyze imaging, clinical, cognitive, and biological data with the aim of facilitating the prediction of psychosis onset and outcome. In this article, we provide an overview of the PSYSCAN protocol and we discuss benefits and methodological challenges of large multicenter studies that employ neuroimaging measures., The PSYSCAN Project is supported by grant agreement no. 603196 under the European Union’s Seventh Framework Programme.
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- 2020
43. Long‐term stability of the cortical volumetric profile and the functional human connectome throughout childhood and adolescence
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Sato, João Ricardo, primary, Biazoli, Claudinei Eduardo, additional, Zugman, André, additional, Pan, Pedro Mario, additional, Bueno, Ana Paula Arantes, additional, Moura, Luciana Monteiro, additional, Gadelha, Ary, additional, Picon, Felipe Almeida, additional, Amaro, Edson, additional, Salum, Giovanni Abrahão, additional, Miguel, Euripedes Constantino, additional, Rohde, Luis Augusto, additional, Bressan, Rodrigo Affonseca, additional, and Jackowski, Andrea Parolin, additional
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- 2021
- Full Text
- View/download PDF
44. Pre-training inter-rater reliability of clinical instruments in an international psychosis research project
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Calem, Maria, Tognin, Stefania, Modinos, Gemma, Pisani, Sara, Kraan, Tamar C., van Dam, Daniella S., Burger, Nadine, McGorry, Patrick, Amminger, G. Paul, Politis, Athena, Goodall, Joanne, Borgwardt, Stefan, Studerus, Erich, Gadelha, Ary, Brietzke, Elisa, Asevedo, Graccielle, Asevedo, Elson, Zugman, Andre, Domínguez-Martínez, Tecelli, Monsonet, Manel, Hinojosa, Lidia, Cristóbal-Narváez, Paula, Racioppi, Anna, Kwapil, Thomas R., Kazes, Mathilde, Daban, Claire, Bourgin, Julie, Gay, Olivier, Mam-Lam-Fook, Célia, Nordholm, Dorte, Randers, Lasse, Krakauer, Kristine, Glenthøj, Louise Birkedal, Glenthøj, Birte, Gebhard, Dominika, Arnhold, Julia, Klosterkötter, Joachim, Lasser, Iris, Winklbaur, Bernadette, Delespaul, Philippe A., Berendsen, Steven, Kapitein, Pim, Schirmbeck, Frederike, van Tricht, Mirjam J., McGuire, Philip, Morgan, Craig, Gayer-Anderson, Charlotte, Kempton, Matthew J., Valmaggia, Lucia, Quattrone, Diego, di Forti, Marta, van der Gaag, Mark, Kirkbride, James B., Jongsma, Hannah E., Jones, Peter B., Parellada, Maria, Arango, Celso, Arrojo, Manuel, Bernardo, Miguel, Sanjuán, Julio, Santos, José Luis, Szöke, Andrei, Tortelli, Andrea, Llorca, Pierre-Michel, Tarricone, Ilaria, Tripoli, Giada, Ferraro, Laura, La Cascia, Caterina, Lasalvia, Antonio, Tosato, Sarah, Menezes, Paulo Rossi, Del-Ben, Cristina Marta, Nelson, Barnaby, Riecher-Rössler, Anita, Bressan, Rodrigo, Barrantes-Vidal, Neus, Krebs, Marie-Odile, Nordentoft, Merete, Ruhrmann, Stephan, Sachs, Gabriele, Rutten, Bart P.F., van Os, Jim, Velthorst, Eva, and de Haan, Lieuwe
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- 2021
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45. Obsessive-Compulsive Symptoms, Polygenic Risk Score, and Thalamic Development in Children From the Brazilian High-Risk Cohort for Mental Conditions (BHRCS)
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Ravagnani Salto, Ana Beatriz, primary, Santoro, Marcos L., additional, Hoexter, Marcelo Q., additional, Jackowski, Andrea Parolin, additional, Pan, Pedro M., additional, Rosário, Maria Conceição, additional, Belangero, Sintia I., additional, Alvarenga, Pedro Gomes, additional, Doretto, Victoria Fogaça, additional, Fumo, Afonso Mazine Tiago, additional, Batistuzzo, Marcelo C., additional, Macul Ferreira de Barros, Pedro, additional, Timpano, Kiara R., additional, Ota, Vanessa K., additional, Rohde, Luis Augusto, additional, Miguel, Euripedes Constantino, additional, Leckman, James F., additional, and Zugman, André, additional
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- 2021
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46. Obsessive-compulsive symptoms, polygenic risk score, and thalamic development in children from the Brazilian High-Risk Cohort for Mental Conditions (BHRCS)
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Salto, Ana Beatriz Ravagnani, Santoro, Marcos Leite, Hoexter, Marcelo Queiroz, Jackowski, Andrea Parolin, Pan, Pedro Mario, Rosário, Maria Conceição do, Belangero, Síntia Iole Nogueira, Alvarenga, Pedro Gomes de, Doretto, Victoria Fogaça, Fumo, Afonso Mazine Tiago, Batistuzzo, Marcelo Camargo, Barros, Pedro Macul Ferreira de, Timpano, Kiara R., Ota, Vanessa Kiyomi Arashiro, Rohde, Luis Augusto Paim, Miguel, Eurípedes Constantino, Leckman, James F., and Zugman, André
- Subjects
Transtorno obsessivo-compulsivo ,Obsessive-compulsive symptoms ,Magnetic resonance imaging ,Thalamus ,Polygenic risk score ,Imageamento por ressonância magnética ,Obsessive-compulsive disorder ,Neuroimaging ,Neuroimagem ,OCD-PRS ,Tálamo ,Herança multifatorial ,MRI - Abstract
Background: Thalamic volume measures have been linked to obsessive-compulsive disorder (OCD) in children and adolescents. However, it is unclear if alterations in thalamic volumes occur before or after symptom onset and if there is a relation to the presence of sub-clinical obsessive-compulsive symptoms (OCS). Here, we explore the relationship between OCS and the rate of thalamic volume change in a cohort of children and youth at high risk to develop a mental disorder. A secondary aim was to determine if there is a relationship between OCS and the individual’s OCD polygenic risk score (OCD-PRS) and between the rate of thalamic volume change and the OCD-PRS. Methods: The sample included 378 children enrolled in the longitudinal Brazilian High-Risk Cohort for Mental Conditions. Participants were assessed for OCS and the symmetrized percent change (SPC) of thalamic volume across two time-points separated by 3 years, along with the OCD-PRS. Zero-altered negative binomial models were used to analyze the relationship between OCS and thalamic SPC. Multiple linear regressions were used to examine the relationship between thalamic SPC and OCD-PRS. Results: A significant relationship between OCS and the right thalamus SPC (p = 0.042) was found. There was no significant relationship between changes in thalamic volume SPC and OCD-PRS. Conclusions: The findings suggest that changes in the right thalamic volume over the course of 3 years in children may be associated to OCS. Future studies are needed to confirm these results and further characterize the specific nature of OCS symptoms associated with thalamic volumes.
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- 2021
47. methods in : The experience of the generalized anxiety disorder working group
- Author
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Zugman, André, Harrewijn, Anita, Cardinale, Elise M., Zwiebel, Hannah, Freitag, Gabrielle F., Werwath, Katy E., Bas-Hoogendam, Janna M., Groenewold, Nynke A., Aghajani, Moji, Hilbert, Kevin, Cardoner, N. (Narcís), Porta-Casteràs, Daniel, Gosnell, Savannah, Salas, Ramiro, Blair, Karina S., Blair, James R., Hammoud, Mira Z., Milad, Mohammed, Burkhouse, Katie, Phan, K. Luan, Schroeder, Heidi K., Strawn, Jeffrey R., Beesdo-Baum, Katja, Thomopoulos, Sophia I., Grabe, Hans J., Van der Auwera, Sandra, Wittfeld, Katharina, Nielsen, Jared A., Buckner, Randy, Smoller, Jordan W., Mwangi, Benson, Soares, Jair C., Wu, Mon-Ju, Zunta-Soares, Giovana B., Jackowski, Andrea P., Pan, Pedro M., Salum, Giovanni A., Assaf, Michal, Diefenbach, Gretchen J., Brambilla, Paolo, Maggioni, Eleonora, Hofmann, David, Straube, Thomas, Andreescu, Carmen, Berta, Rachel, Tamburo, Erica, Price, Rebecca, Manfro, Gisele G., Critchley, Hugo D., Makovac, Elena, Mancini, Matteo, Meeten, Frances, Ottaviani, Cristina, Agosta, Federica, Canu, Elisa, Cividini, Camilla, Filippi, Massimo, Kostić, Milutin, Munjiza, Ana, Filippi, Courtney A., Leibenluft, Ellen, Alberton, Bianca A. V., Balderston, Nicholas L., Ernst, Monique, Grillon, Christian, Mujica-Parodi, Lilianne R., van Nieuwenhuizen, Helena, Fonzo, Gregory A., Paulus, Martin P., Stein, Murray B., Gur, Raquel E., Gur, Ruben C., Kaczkurkin, Antonia N., Larsen, Bart, Satterthwaite, Theodore D., Harper, Jennifer, Myers, Michael, Perino, Michael T., Yu, Qiongru, Sylvester, Chad M., Veltman, Dick J., Lueken, Ulrike, Van der Wee, Nic J. A., Stein, Dan J., Jahanshad, Neda, Thompson, Paul M., Pine, Daniel S., Winkler, Anderson M., and Universitat Autònoma de Barcelona
- Subjects
Generalized anxiety disorder ,Meta-analyses ,Data sharing ,Neuroimaging ,Mega-analyses - Abstract
The ENIGMA group on Generalized Anxiety Disorder (ENIGMA-Anxiety/GAD) is part of a broader effort to investigate anxiety disorders using imaging and genetic data across multiple sites worldwide. The group is actively conducting a mega-analysis of a large number of brain structural scans. In this process, the group was confronted with many methodological challenges related to study planning and implementation, between-country transfer of subject-level data, quality control of a considerable amount of imaging data, and choices related to statistical methods and efficient use of resources. This report summarizes the background information and rationale for the various methodological decisions, as well as the approach taken to implement them. The goal is to document the approach and help guide other research groups working with large brain imaging data sets as they develop their own analytic pipelines for mega-analyses. This report summarizes the background information and rationale for the various methodological decisions made by the ENIGMA-GAD group. The aim of this work is to help guide other research groups working with large brain imaging data sets
- Published
- 2020
48. Lowering costs for large-scale screening in psychosis: a systematic review and meta-analysis of performance and value of information for speech-based psychiatric evaluation
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Argolo, Felipe, primary, Magnavita, Guilherme, additional, Mota, Natalia Bezerra, additional, Ziebold, Carolina, additional, Mabunda, Dirceu, additional, Pan, Pedro M., additional, Zugman, André, additional, Gadelha, Ary, additional, Corcoran, Cheryl, additional, and Bressan, Rodrigo A., additional
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- 2020
- Full Text
- View/download PDF
49. Recognition of bipolar disorder type I before the first manic episode: challenges and developments
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Noto, Mariane Nunes, de Souza Noto, Cristiano, de Jesus, Danilo Rocha, Zugman, André, Mansur, Rodrigo B, Berberian, Arthur A, Leclerc, Emilie, McIntyre, Roger S, Correll, Christoph U, and Brietzke, Elisa
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- 2013
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50. Cytokines in schizophrenia: Possible role of anti-inflammatory medications in clinical and preclinical stages
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Mansur, Rodrigo Barbachan, Zugman, André, de Miranda Asevedo, Elson, da Cunha, Graccielle Rodrigues, Bressan, Rodrigo Affonseca, and Brietzke, Elisa
- Published
- 2012
- Full Text
- View/download PDF
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