364 results on '"Zuercher, William J."'
Search Results
2. Structure-Bioactivity Relationship for Benzimidazole Thiophene Inhibitors of Polo-Like Kinase 1 (PLK1), a Potential Drug Target in Schistosoma mansoni.
3. The promise and peril of chemical probes
4. A Perspective on Extreme Open Science: Companies Sharing Compounds without Restriction
5. WNT Activates the AAK1 Kinase to Promote Clathrin-Mediated Endocytosis of LRP6 and Establish a Negative Feedback Loop
6. Application of Integrated Drug Screening/Kinome Analysis to Identify Inhibitors of Gemcitabine-Resistant Pancreatic Cancer Cell Growth
7. A screen for kinase inhibitors identifies antimicrobial imidazopyridine aminofurazans as specific inhibitors of the Listeria monocytogenes PASTA kinase PrkA
8. Targeting aurora kinases as a potential prognostic and therapeutical biomarkers in pediatric acute lymphoblastic leukaemia
9. A novel screening approach comparing kinase activity of small molecule inhibitors with similar molecular structures and distinct biologic effects in triple-negative breast cancer to identify targetable signaling pathways
10. Using a Genetically Encoded Sensor to Identify Inhibitors of Toxoplasma gondii Ca2+ Signaling
11. Gram-scale synthesis of FICZ, a photoreactive endogenous ligand of the aryl hydrocarbon receptor
12. CaMKK2 in myeloid cells is a key regulator of the immune-suppressive microenvironment in breast cancer
13. Structure-activity relationship of dihydropyridines for rhabdomyosarcoma
14. Transactivation Function-2 of Estrogen Receptor α Contains Transactivation Function-1-regulating Element
15. Dual Inhibition of Mycobacterium tuberculosis and the Host TGFBR1 by an Anilinoquinazoline.
16. Kinase Inhibitor Screening Displayed ALK as a Possible Therapeutic Biomarker for Gastric Cancer
17. Comprehensive characterization of the Published Kinase Inhibitor Set
18. The Development of a High-Content Screening Binding Assay for the Smoothened Receptor
19. RIOK2: straddling the kinase/ATPase line
20. Multiparameter phenotypic screening for endogenous TFEB and TFE3 translocation identifies novel chemical series modulating lysosome function
21. Temozolomide-induced guanine mutations create exploitable vulnerabilities of guanine-rich DNA and RNA regions in drug-resistant gliomas
22. Estrogen-related receptor-α is a metabolic regulator of effector T-cell activation and differentiation
23. Dual Inhibition of Mycobacterium tuberculosisand the Host TGFBR1 by an Anilinoquinazoline
24. The Metabolic Regulator ERRα, a Downstream Target of HER2/IGF-1R, as a Therapeutic Target in Breast Cancer
25. Multiparameter phenotypic screening for endogenous TFEB and TFE3 translocation identifies novel chemical series modulating lysosome function.
26. Targeting Never-In-Mitosis-A Related Kinase 5 in Cancer: A Review
27. Chemical Probes for Understudied Kinases: Challenges and Opportunities
28. Potent antiviral activity of novel multi-substituted 4-anilinoquin(az)olines
29. Discovery of a Potent Dual SLK/STK10 Inhibitor Based on a Maleimide Scaffold
30. Hinge Binder Scaffold Hopping Identifies Potent Calcium/Calmodulin-Dependent Protein Kinase Kinase 2 (CAMKK2) Inhibitor Chemotypes
31. NEK5 activity regulates the mesenchymal and migratory phenotype in breast cancer cells
32. The Kinase Chemogenomic Set (KCGS): an open science resource for kinase vulnerability identification
33. Identifying the target of an antiparasitic compound in Toxoplasma using thermal proteome profiling
34. Crystal structure of the PXR–T1317 complex provides a scaffold to examine the potential for receptor antagonism
35. NEK5 Activity Regulates the Mesenchymal and Migratory Phenotype in Breast Cancer Cells
36. X-ray Crystal Structures of the Estrogen-related Receptor-γ Ligand Binding Domain in Three Functional States Reveal the Molecular Basis of Small Molecule Regulation
37. The Kinase Chemogenomic Set (KCGS): An Open Science Resource for Kinase Vulnerability Identification
38. Towards a RIOK2 chemical probe: cellular potency improvement of a selective 2-(acylamino)pyridine series
39. Anti-tubercular activity of novel 4-anilinoquinolines and 4-anilinoquinazolines
40. Utilizing comprehensive and mini-kinome panels to optimize the selectivity of quinoline inhibitors for cyclin G associated kinase (GAK)
41. Ligand-Dependent Regulation of the Activity of the Orphan Nuclear Receptor, Small Heterodimer Partner (SHP), in the Repression of Bile Acid Biosynthetic CYP7A1 and CYP8B1 Genes
42. A Chemical Probe for Dark Kinase STK17B Derives Its Potency and High Selectivity through a Unique P-Loop Conformation
43. Identifying the Target of an Antiparasitic Compound in Toxoplasma Using Thermal Proteome Profiling
44. CDK12 inhibition reduces abnormalities in cells from patients with myotonic dystrophy and in a mouse model
45. New Insights into 4-Anilinoquinazolines as Inhibitors of Cardiac Troponin I–Interacting Kinase (TNNi3K)
46. Identification of drug modifiers for RYR1-related myopathy using a multi-species discovery pipeline
47. Author response: Identification of drug modifiers for RYR1-related myopathy using a multi-species discovery pipeline
48. Overcoming Fungal Echinocandin Resistance through Inhibition of the Non-essential Stress Kinase Yck2
49. An efficient, general asymmetric synthesis of carbocyclic nucleosides: application of an asymmetric aldol/ring-closing metathesis strategy
50. Selective Partial Agonism of Liver X Receptor α Is Related to Differential Corepressor Recruitment
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