Search

Your search keyword '"Zucman-Rossi , Jessica"' showing total 1,446 results
Start Over Author "Zucman-Rossi , Jessica"
1,446 results on '"Zucman-Rossi , Jessica"'

1. Single-cell multiomics reveals the interplay of clonal evolution and cellular plasticity in hepatoblastoma

Author

Roehrig, Amélie, Hirsch, Theo Z., Pire, Aurore, Morcrette, Guillaume, Gupta, Barkha, Marcaillou, Charles, Imbeaud, Sandrine, Chardot, Christophe, Gonzales, Emmanuel, Jacquemin, Emmanuel, Sekiguchi, Masahiro, Takita, Junko, Nagae, Genta, Hiyama, Eiso, Guérin, Florent, Fabre, Monique, Aerts, Isabelle, Taque, Sophie, Laithier, Véronique, Branchereau, Sophie, Guettier, Catherine, Brugières, Laurence, Fresneau, Brice, Zucman-Rossi, Jessica, and Letouzé, Eric

Published
2024
Full Text
View/download PDF

3. A spatial architecture-embedding HLA signature to predict clinical response to immunotherapy in renal cell carcinoma

Author

Kinget, Lisa, Naulaerts, Stefan, Govaerts, Jannes, Vanmeerbeek, Isaure, Sprooten, Jenny, Laureano, Raquel S., Dubroja, Nikolina, Shankar, Gautam, Bosisio, Francesca M., Roussel, Eduard, Verbiest, Annelies, Finotello, Francesca, Ausserhofer, Markus, Lambrechts, Diether, Boeckx, Bram, Wozniak, Agnieszka, Boon, Louis, Kerkhofs, Johan, Zucman-Rossi, Jessica, Albersen, Maarten, Baldewijns, Marcella, Beuselinck, Benoit, and Garg, Abhishek D.

Published
2024
Full Text
View/download PDF

5. Author Correction: A spatial architecture-embedding HLA signature to predict clinical response to immunotherapy in renal cell carcinoma

Author

Kinget, Lisa, Naulaerts, Stefan, Govaerts, Jannes, Vanmeerbeek, Isaure, Sprooten, Jenny, Laureano, Raquel S., Dubroja, Nikolina, Shankar, Gautam, Bosisio, Francesca M., Roussel, Eduard, Verbiest, Annelies, Finotello, Francesca, Ausserhofer, Markus, Lambrechts, Diether, Boeckx, Bram, Wozniak, Agnieszka, Boon, Louis, Kerkhofs, Johan, Zucman-Rossi, Jessica, Albersen, Maarten, Baldewijns, Marcella, Beuselinck, Benoit, and Garg, Abhishek D.

Published
2024
Full Text
View/download PDF

8. List of Contributors

Author

Adsay, N. Volkan, primary, Alves, Venancio A.F., additional, Anstee, Quentin M., additional, Basturk, Olca, additional, Bellamy, Christopher O.C., additional, Brunt, Elizabeth M., additional, Burt, Alastair D., additional, Clouston, Andrew D., additional, Crawford, James M., additional, Ferrell, Linda D., additional, Gonzalez, Raul S., additional, Guido, Maria, additional, Hale, Gillian L., additional, Hübscher, Stefan G., additional, Hytiroglou, Prodromos, additional, Kakar, Sanjay, additional, Kleiner, David E., additional, Lohse, Ansgar W., additional, Mangia, Alessandra, additional, Nakanuma, Yasuni, additional, Paradis, Valerie, additional, Pietrangelo, Antonello, additional, Quaglia, Alberto, additional, Roberts, Eve A., additional, Terracciano, Luigi M., additional, Theise, Neil D., additional, Tiniakos, Dina G., additional, Torbenson, Michael, additional, Washington, Kay, additional, Wee, Aileen, additional, Yeh, Matthew M., additional, Zaki, Sherif R., additional, Zen, Yoh, additional, and Zucman-Rossi, Jessica, additional

Published
2024
Full Text
View/download PDF

9. DLK1/DIO3 locus upregulation by a β-catenin-dependent enhancer drives cell proliferation and liver tumorigenesis

Author

Sanceau, Julie, Poupel, Lucie, Joubel, Camille, Lagoutte, Isabelle, Caruso, Stefano, Pinto, Sandra, Desbois-Mouthon, Christèle, Godard, Cécile, Hamimi, Akila, Montmory, Enzo, Dulary, Cécile, Chantalat, Sophie, Roehrig, Amélie, Muret, Kevin, Saint-Pierre, Benjamin, Deleuze, Jean-François, Mouillet-Richard, Sophie, Forné, Thierry, Grosset, Christophe F., Zucman-Rossi, Jessica, Colnot, Sabine, and Gougelet, Angélique

Published
2024
Full Text
View/download PDF

10. Mutational signature, cancer driver genes mutations and transcriptomic subgroups predict hepatoblastoma survival

Author

Pire, Aurore, Hirsch, Theo Z., Morcrette, Guillaume, Imbeaud, Sandrine, Gupta, Barkha, Pilet, Jill, Cornet, Marianna, Fabre, Monique, Guettier, Catherine, Branchereau, Sophie, Brugières, Laurence, Guerin, Florent, Laithier, Véronique, Coze, Carole, Nagae, Genta, Hiyama, Eiso, Laurent-Puig, Pierre, Rebouissou, Sandra, Sarnacki, Sabine, Chardot, Christophe, Capito, Carmen, Faure-Conter, Cécile, Aerts, Isabelle, Taque, Sophie, Fresneau, Brice, and Zucman-Rossi, Jessica

Published
2024
Full Text
View/download PDF

13. Identification and experimental validation of druggable epigenetic targets in hepatoblastoma

Author

Clavería-Cabello, Alex, Herranz, Jose Maria, Latasa, Maria Ujue, Arechederra, Maria, Uriarte, Iker, Pineda-Lucena, Antonio, Prosper, Felipe, Berraondo, Pedro, Alonso, Cristina, Sangro, Bruno, García Marin, Jose Juan, Martinez-Chantar, Maria Luz, Ciordia, Sergio, Corrales, Fernando José, Francalanci, Paola, Alaggio, Rita, Zucman-Rossi, Jessica, Indersie, Emilie, Cairo, Stefano, Domingo-Sàbat, Montserrat, Zanatto, Laura, Sancho-Bru, Pau, Armengol, Carolina, Berasain, Carmen, Fernandez-Barrena, Maite García, and Avila, Matias Antonio

Published
2023
Full Text
View/download PDF

17. Integrating genetic variants into clinical models for hepatocellular carcinoma risk stratification in cirrhosis

Author

Nahon, Pierre, Asselah, Tarik, Guyader, Dominique, Pol, Stanislas, Fontaine, Hélène, Pageaux, Georges-Philippe, De Lédinghen, Victor, Ouzan, Denis, Zoulim, Fabien, Roulot, Dominique, Tran, Albert, Bronowicki, Jean-Pierre, Decaensi, Thomas, Riachi, Ghassan, Calès, Paul, Péron, Jean-Marie, Alric, Laurent, Bourlière, Marc, Mathurin, Philippe, Dharancy, Sebastien, Blanc, Jean-Frédéric, Abergel, Armand, Chazouillères, Olivier, Mallat, Ariane, Grangé, Jean-Didier, Attali, Pierre, Louis d’Alteroche, Wartelle, Claire, Dao, Thông, Thabut, Dominique, Pilette, Christophe, Silvain, Christine, Christidis, Christos, Nguyen-Khac, Eric, Bernard-Chabert, Brigitte, Hillaire, Sophie, Di Martino, Vincent, Ganne-Carrié, Nathalie, Chaffaut, Cendrine, Archambeaud, Isabelle, d’Alteroche, Louis, Oberti, Frédéric, Moreno, Christophe, Louvet, Alexandre, Moirand, Romain, Goria, Odile, Carbonell, Nicolas, Duclos-Vallée, Jean-Charles, de Ledinghen, Victor, Ozenne, Violaine, Henrion, Jean, Perlemuter, Gabriel, Amiot, Xavier, Zarski, Jean-Pierre, Chevret, Sylvie, Bamba-Funck, Jessica, Layese, Richard, Trépo, Eric, Zucman-Rossi, Jessica, Cagnot, Carole, Guyot, Erwan, Ziol, Marianne, Sutton, Angela, and Audureau, Etienne

Published
2023
Full Text
View/download PDF

19. Opposing roles of hepatic stellate cell subpopulations in hepatocarcinogenesis

Author

Filliol, Aveline, Saito, Yoshinobu, Nair, Ajay, Dapito, Dianne H., Yu, Le-Xing, Ravichandra, Aashreya, Bhattacharjee, Sonakshi, Affo, Silvia, Fujiwara, Naoto, Su, Hua, Sun, Qiuyan, Savage, Thomas M., Wilson-Kanamori, John R., Caviglia, Jorge M., Chin, LiKang, Chen, Dongning, Wang, Xiaobo, Caruso, Stefano, Kang, Jin Ku, Amin, Amit Dipak, Wallace, Sebastian, Dobie, Ross, Yin, Deqi, Rodriguez-Fiallos, Oscar M., Yin, Chuan, Mehal, Adam, Izar, Benjamin, Friedman, Richard A., Wells, Rebecca G., Pajvani, Utpal B., Hoshida, Yujin, Remotti, Helen E., Arpaia, Nicholas, Zucman-Rossi, Jessica, Karin, Michael, Henderson, Neil C., Tabas, Ira, and Schwabe, Robert F.

Published
2022
Full Text
View/download PDF

20. Inhibiting Glutamine-Dependent mTORC1 Activation Ameliorates Liver Cancers Driven by β-Catenin Mutations

Author

Adebayo Michael, Adeola O, Ko, Sungjin, Tao, Junyan, Moghe, Akshata, Yang, Hong, Xu, Meng, Russell, Jacquelyn O, Pradhan-Sundd, Tirthadipa, Liu, Silvia, Singh, Sucha, Poddar, Minakshi, Monga, Jayvir S, Liu, Pin, Oertel, Michael, Ranganathan, Sarangarajan, Singhi, Aatur, Rebouissou, Sandra, Zucman-Rossi, Jessica, Ribback, Silvia, Calvisi, Diego, Qvartskhava, Natalia, Görg, Boris, Häussinger, Dieter, Chen, Xin, and Monga, Satdarshan P

Subjects
Chronic Liver Disease and Cirrhosis, Liver Cancer, Genetics, Liver Disease, Cancer, Digestive Diseases, Rare Diseases, Acetates, Animals, Carcinoma, Hepatocellular, Cell Line, Tumor, Cell Proliferation, Cell Survival, Child, Child, Preschool, Disease Models, Animal, Female, Glutamate-Ammonia Ligase, Glutamine, Hepatocytes, Humans, Infant, Liver Neoplasms, Male, Mechanistic Target of Rapamycin Complex 1, Mice, Mice, Inbred C57BL, Mice, Knockout, Mutation, Phenols, Retrospective Studies, Sirolimus, TOR Serine-Threonine Kinases, Transfection, Wnt Signaling Pathway, beta Catenin, Wnt, beta-catenin, glutamine synthetase, hepatocellular cancer, liver tumor, mTOR, metabolic zonation, personalized medicine, precision therapy, tumor metabolism, Biochemistry and Cell Biology, Medical Biochemistry and Metabolomics, Endocrinology & Metabolism
Abstract

Based on their lobule location, hepatocytes display differential gene expression, including pericentral hepatocytes that surround the central vein, which are marked by Wnt-β-catenin signaling. Activating β-catenin mutations occur in a variety of liver tumors, including hepatocellular carcinoma (HCC), but no specific therapies are available to treat these tumor subsets. Here, we identify a positive relationship between β-catenin activation, its transcriptional target glutamine synthetase (GS), and p-mTOR-S2448, an indicator of mTORC1 activation. In normal livers of mice and humans, pericentral hepatocytes were simultaneously GS and p-mTOR-S2448 positive, as were β-catenin-mutated liver tumors. Genetic disruption of β-catenin signaling or GS prevented p-mTOR-S2448 expression, while its forced expression in β-catenin-deficient livers led to ectopic p-mTOR-S2448 expression. Further, we found notable therapeutic benefit of mTORC1 inhibition in mutant-β-catenin-driven HCC through suppression of cell proliferation and survival. Thus, mTORC1 inhibitors could be highly relevant in the treatment of liver tumors that are β-catenin mutated and GS positive.

Published
2019

21. Functional characterization of 5p15.33 risk locus in uveal melanoma reveals rs452384 as a functional variant and NKX2.4 as an allele-specific interactor

Author

Derrien, Anne-Céline, Houy, Alexandre, Ganier, Olivier, Dingli, Florent, Ningarhari, Massih, Mobuchon, Lenha, Espejo Díaz, María Isabel, Loew, Damarys, Cassoux, Nathalie, Cussenot, Olivier, Cancel-Tassin, Géraldine, Margueron, Raphael, Noirel, Josselin, Zucman-Rossi, Jessica, Rodrigues, Manuel, and Stern, Marc-Henri

Published
2022
Full Text
View/download PDF

22. Bi-allelic hydroxymethylbilane synthase inactivation defines a homogenous clinico-molecular subtype of hepatocellular carcinoma

Author

Le Bail, Brigitte, Chiche, Laurence, Bioulac-Sage, Paulette, Balabaud, Charles, Possenti, Laurent, Decraecker, Marie, Paradis, Valérie, Laurent, Alexis, Molina, Laura, Zhu, Junjie, Trépo, Eric, Bayard, Quentin, Amaddeo, Giuliana, Blanc, Jean-Frédéric, Calderaro, Julien, Ma, Xiaochao, Zucman-Rossi, Jessica, and Letouzé, Eric

Published
2022
Full Text
View/download PDF

25. Socioeconomic Deprivation Weighs Heavily on Liver Fibrosis and Mortality After Hepatitis C Cure (ANRS CO22 Hepather).

Author

Barré, Tangui, Parlati, Lucia, Bourlière, Marc, Ramier, Clémence, Marcellin, Fabienne, Protopopescu, Camelia, Di Beo, Vincent, Moins, Cécile, Dorival, Celine, Nicol, Jérôme, Zucman‐Rossi, Jessica, Mathurin, Philippe, Larrey, Dominique, Boursier, Jérôme, Carrat, Fabrice, Carrieri, Patrizia, Alric, Laurent, Bonnet, Delphine, Payssan‐Sicart, Virginie, and Pomes, Chloe

Subjects
HEPATIC fibrosis, PROPORTIONAL hazards models, HEPATITIS C virus, SMOKING, ALCOHOL drinking
Abstract

Although Hepatitis C virus (HCV) infection can be cured with direct‐acting antivirals (DAA), some cured patients face a serious risk of advanced liver damage and early mortality. In order to avoid these two negative health outcomes, it is important to identify and assess related risk factors. Little is currently known about socioeconomic and behavioural factors in this context. Using data from the ANRS CO22 Hepather cohort, we tested for associations between socioeconomic and behavioural factors and (i) advanced liver fibrosis (defined as an FIB‐4 > 3.25) assessed longitudinally using a mixed‐effects logistic regression model (both the whole population and stratified on advanced liver fibrosis status at the time of HCV cure) and (ii) all‐cause mortality (Cox proportional hazards model), during post‐HCV cure follow‐up. Among 5833 participants cured of HCV, living in poverty was associated with postcure advanced liver fibrosis in participants without this diagnosis at the time of HCV cure (population attributable fraction—PAF—of 8.6%) and with mortality in the whole study population (PAF of 10.6%). The detrimental effects of unhealthy alcohol use and heavy tobacco smoking, as well as the beneficial effect of living with a stable partner were also highlighted. We highlighted the major role of poverty and behavioural factors in advanced liver fibrosis and all‐cause mortality in patients cured of HCV. Encouraging linkage to social support services and healthy behaviours after successful DAA treatment could limit morbidity and increase survival in this population. Clinical Trial Registration: ClinicalTrials.gov: NCT01953458 [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

26. Nivolumab, nivolumab–ipilimumab, and VEGFR-tyrosine kinase inhibitors as first-line treatment for metastatic clear-cell renal cell carcinoma (BIONIKK): a biomarker-driven, open-label, non-comparative, randomised, phase 2 trial

Author

Vano, Yann-Alexandre, Elaidi, Réza, Bennamoun, Mostefa, Chevreau, Christine, Borchiellini, Delphine, Pannier, Diane, Maillet, Denis, Gross-Goupil, Marine, Tournigand, Christophe, Laguerre, Brigitte, Barthélémy, Philippe, Coquan, Elodie, Gravis, Gwenaëlle, Houede, Nadine, Cancel, Mathilde, Huillard, Olivier, Beuzeboc, Philippe, Fournier, Laure, Méjean, Arnaud, Cathelineau, Xavier, Doumerc, Nicolas, Paparel, Philippe, Bernhard, Jean-Christophe, de la Taille, Alexandre, Bensalah, Karim, Tricard, Thibault, Waeckel, Thibaut, Pignot, Géraldine, Braychenko, Elena, Caruso, Stefano, Sun, Cheng-Ming, Verkarre, Virginie, Lacroix, Guillaume, Moreira, Marco, Meylan, Maxime, Bougouïn, Antoine, Phan, Letuan, Thibault-Carpentier, Christelle, Zucman-Rossi, Jessica, Fridman, Wolf Herman, Sautès-Fridman, Catherine, and Oudard, Stéphane

Published
2022
Full Text
View/download PDF

29. cHCC‐CCA: Consensus terminology for primary liver carcinomas with both hepatocytic and cholangiocytic differentation

Author

Brunt, Elizabeth, Aishima, Shinichi, Clavien, Pierre‐Alain, Fowler, Kathryn, Goodman, Zachary, Gores, Gregory, Gouw, Annette, Kagen, Alex, Klimstra, David, Komuta, Mina, Kondo, Fukuo, Miksad, Rebecca, Nakano, Masayuki, Nakanuma, Yasuni, Ng, Irene, Paradis, Valerie, Park, Young Nyun, Quaglia, Alberto, Roncalli, Massimo, Roskams, Tania, Sakamoto, Michiie, Saxena, Romil, Sempoux, Christine, Sirlin, Claude, Stueck, Ashley, Thung, Swan, Tsui, WMS, Wang, Xin‐Wei, Wee, Aileen, Yano, Hirohisa, Yeh, Matthew, Zen, Yoh, Zucman‐Rossi, Jessica, and Theise, Neil

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Liver Cancer, Rare Diseases, Cancer, Liver Disease, Digestive Diseases, Aged, Carcinoma, Hepatocellular, Cholangiocarcinoma, Female, Humans, Liver, Liver Neoplasms, Radiography, Terminology as Topic, Medical Biochemistry and Metabolomics, Immunology, Gastroenterology & Hepatology, Clinical sciences
Abstract

Primary liver carcinomas with both hepatocytic and cholangiocytic differentiation have been referred to as "combined (or mixed) hepatocellular-cholangiocarcinoma." These tumors, although described over 100 years ago, have attracted greater attention recently because of interest in possible stem cell origin and perhaps because of greater frequency and clinical recognition. Currently, because of a lack of common terminology in the literature, effective treatment and predictable outcome data have been challenging to accrue. This article represents a consensus document from an international community of pathologists, radiologists, and clinicians who have studied and reported on these tumors and recommends a working terminology for diagnostic and research approaches for further study and evaluation.ConclusionIt is recommended that diagnosis is based on routine histopathology with hematoxylin and eosin (H&E); immunostains are supportive, but not essential for diagnosis. (Hepatology 2018;68:113-126).

Published
2018

30. Liver Cancer Initiation Requires p53 Inhibition by CD44-Enhanced Growth Factor Signaling

Author

Dhar, Debanjan, Antonucci, Laura, Nakagawa, Hayato, Kim, Ju Youn, Glitzner, Elisabeth, Caruso, Stefano, Shalapour, Shabnam, Yang, Ling, Valasek, Mark A, Lee, Sooyeon, Minnich, Kerstin, Seki, Ekihiro, Tuckermann, Jan, Sibilia, Maria, Zucman-Rossi, Jessica, and Karin, Michael

Subjects
Biochemistry and Cell Biology, Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Biological Sciences, Stem Cell Research, Liver Cancer, Rare Diseases, Liver Disease, Cancer, Digestive Diseases, 2.1 Biological and endogenous factors, Aged, Animals, Carcinoma, Hepatocellular, Cell Line, Tumor, Cells, Cultured, DNA Damage, Female, Gene Expression Regulation, Neoplastic, Hepatocytes, Humans, Hyaluronan Receptors, Liver Neoplasms, Male, Mice, Inbred C57BL, Mice, Knockout, Middle Aged, Signal Transduction, Tumor Suppressor Protein p53, CD44, DNA damage response, EGFR, HCC, MDM2 nuclear translocation, cancer initiation, hepatocellular carcinoma, liver cancer, p53, p53 termination, Neurosciences, Oncology & Carcinogenesis, Biochemistry and cell biology, Oncology and carcinogenesis
Abstract

How fully differentiated cells that experience carcinogenic insults become proliferative cancer progenitors that acquire multiple initiating mutations is not clear. This question is of particular relevance to hepatocellular carcinoma (HCC), which arises from differentiated hepatocytes. Here we show that one solution to this problem is provided by CD44, a hyaluronic acid receptor whose expression is rapidly induced in carcinogen-exposed hepatocytes in a STAT3-dependent manner. Once expressed, CD44 potentiates AKT activation to induce the phosphorylation and nuclear translocation of Mdm2, which terminates the p53 genomic surveillance response. This allows DNA-damaged hepatocytes to escape p53-induced death and senescence and respond to proliferative signals that promote fixation of mutations and their transmission to daughter cells that go on to become HCC progenitors.

Published
2018

32. Early hepatocellular carcinoma detection using magnetic resonance imaging is cost-effective in high-risk patients with cirrhosis

Author

Nahon, Pierre, Asselah, Tarik, Guyader, Dominique, Pol, Stanislas, Fontaine, Hélène, Pageaux, Georges-Philippe, De Lédinghen, Victor, Ouzan, Denis, Zoulim, Fabien, Roulot, Dominique, Tran, Albert, Bronowicki, Jean-Pierre, Decaensi, Thomas, Riachi, Ghassan, Calès, Paul, Péron, Jean-Marie, Alric, Laurent, Bourlière, Marc, Mathurin, Philippe, Dharancy, Sebastien, Blanc, Jean-Frédéric, Abergel, Armand, Chazouillères, Olivier, Mallat, Ariane, Grangé, Jean-Didier, Attali, Pierre, d’Alteroche, Louis, Wartelle, Claire, Dao, Thông, Thabut, Dominique, Pilette, Christophe, Silvain, Christine, Christidis, Christos, Nguyen-Khac, Eric, Bernard-Chabert, Brigitte, Hillaire, Sophie, Di Martino, Vincent, Bonnet, Delphine, Payssan-Sicart, Virginie, Pomes, Chloe, Bailly, François, Beaudoin, Marjolaine, Giboz, Dominique, Hartig-Lavie, Kerstin, Maynard, Marianne, Billaud, Eric, Boutoille, David, Cavellec, Morane, Cheraud-Carpentier, Marjorie, Hubert, Isabelle, Benhida, Jaouad, Lannes, Adrien, Lunel, Françoise, Oberti, Frédéric, Boyer, Nathalie, Giuily, Nathalie, Castelnau, Corinne, Scoazec, Giovanna, Chibah, Aziza, Keser, Sylvie, Bonardi, Karim, Vallet-Pichard, Anaïs, Sogni, Philippe, Foucher, Juliette, Hiriart, Jean-Baptiste, Wilson, Amy, Shili, Sarah, Chermak, Faiza, Ansaldi, Christelle, Ben Amara, Nisserine, Chouquet, Laëtitia, De Luca, Emilie, Oules, Valérie, Anty, Rodolphe, Gelsi, Eve, Truchi, Régine, Luckina, Elena, Messaoudi, Nadia, Moussali, Joseph, De Dieuleveult, Barbara, Labarriere, Damien, Poter, Pascal, Si Ahmed, Si Nafa, Grando-Lemaire, Véronique, Bourcier, Valérie, Brulé, Séverine, Stalhberger, Thomas, Jezequel, Caroline, Brener, Audrey, Laligant, Anne, Rabot, Aline, Renard, Isabelle, Baumert, Thomas F., Dofföel, Michel, Mutter, Catherine, Simo-Noumbissie, Pauline, Razi, Esma, Barraud, Hélène, Bensenane, Mouni, Nani, Abdelbasset, Hassani-Nani, Sarah, Bernard, Marie-Albertine, Bismuth, Michael, Caillo, Ludovic, Faure, Stéphanie, Ripault, Marie Pierre, Bureau, Christophe, Peron, Jean Marie, Robic, Marie Angèle, Tarallo, Léa, Faure, Marine, Froissart, Bruno, Hilleret, Marie-Noelle, Zarski, Jean-Pierre, Goria, Odile, Grard, Victorien, Montialoux, Hélène, François, Muriel, Ouedraogo, Christian, Pauleau, Christelle, Varault, Anne, Andreani, Tony, Angoulevant, Bénédicte, Chevance, Azeline, Serfaty, Lawrence, Antonini, Teresa, Coilly, Audrey, Duclos Vallée, Jean-Charles, Tateo, Mariagrazia, Bonny, Corinne, Brigitte, Chanteranne, Lamblin, Géraldine, Muti, Léon, Babouri, Abdenour, Filipe, Virginie, Barrault, Camille, Costes, Laurent, Hagège, Hervé, Merbah, Soraya, Carrier, Paul, Debette-Gratien, Maryline, Jacques, Jérémie, Lassailly, Guillaume, Artu, Florent, Canva, Valérie, Dharancy, Sébastien, Louvet, Alexandre, Latournerie, Marianne, Bardou, Marc, Mouillot, Thomas, Bacq, Yannick, Barbereau, Didier, Nicolas, Charlotte, Chevalier, Caroline, Archambeaud, Isabelle, Habes, Sarah, Botta-Fridlund, Danièle, Saillard, Eric, Lafrance, Marie-Josée, Cacoub, Patrice, Carrat, Fabrice, Carrieri, Patrizia, Delarocque-Astagneau, Elisabeth, De Ledinghen, Victor, Dorival, Céline, Dubuisson, Jean, Housset, Chantal, Larrey, Dominique, Marcellin, Patrick, Pawlotsky, Jean-Michel, Petrov-Sanchez, Ventzislava, Vaux, Sophie, Wittkop, Linda, Yazdanpanah, Yazdan, Zucman-Rossi, Jessica, Ganne-Carrié, Nathalie, Chaffaut, Cendrine, Moreno, Christophe, Moirand, Romain, Carbonell, Nicolas, Duclos-Vallée, Jean-Charles, de Ledinghen, Victor, Ozenne, Violaine, Henrion, Jean, Perlemuter, Gabriel, Amiot, Xavier, Chevret, Sylvie, Najean, Marie, Layese, Richard, Zarca, Kevin, Segar, Laeticia Blampain, Cagnot, Carole, N’Kontchou, Gisèle, Ronot, Maxime, Audureau, Etienne, and Durand-Zaleski, Isabelle

Published
2022
Full Text
View/download PDF

33. Common genetic variation in alcohol-related hepatocellular carcinoma: a case-control genome-wide association study

Author

Meiller, Clément, Cao, Qian, Hirsch, Théo Z., Rebouissou, Sandra, Degré, Delphine, Otero Sanchez, Lukas, Rosewick, Nicolas, Quertinmont, Eric, Desille-Dugast, Mireille, François-Vié, Muriel, Moins, Cécile, Leteurtre, Emmanuelle, Lassailly, Guillaume, Ningarhari, Massih, Boleslawski, Emmanuel, Cottet, Vanessa, Trépo, Eric, Caruso, Stefano, Yang, Jie, Imbeaud, Sandrine, Couchy, Gabrielle, Bayard, Quentin, Letouzé, Eric, Ganne-Carrié, Nathalie, Moreno, Christophe, Oussalah, Abderrahim, Féray, Cyrille, Blanc, Jean Frédéric, Clément, Bruno, Hillon, Patrick, Boursier, Jérôme, Paradis, Valérie, Calderaro, Julien, Gnemmi, Viviane, Nault, Jean-Charles, Guéant, Jean-Louis, Devière, Jacques, Archambeaud, Isabelle, Vitellius, Carole, Turlin, Bruno, Bronowicki, Jean-Pierre, Gustot, Thierry, Sutton, Angela, Ziol, Marianne, Nahon, Pierre, and Zucman-Rossi, Jessica

Published
2022
Full Text
View/download PDF

34. FRI-459 Outcome of targeting ATR in high replication stress murine HCC

Author

Fang, Jing, primary, He, Qiyuan, additional, Pan, Long, additional, Araujo, Joana Gonçalves, additional, Donné, Romain, additional, Pophillat, Céline, additional, Kabore, Christelle, additional, Lujambio, Amaia, additional, Zucman-Rossi, Jessica, additional, Couty, Jean-Pierre, additional, Morizur, Severine, additional, and Desdouets, Chantal, additional

Published
2024
Full Text
View/download PDF

35. TOP-552 Oncogenic beta-catenin is using CD155 as a molecular actor to corrupt immunosurveillance of cold HCC

Author

Araujo, Joana Gonçalves, primary, Pophillat, Céline, additional, Gougelet, Angélique, additional, Caruso, Stefano, additional, Cadoux, Mathilde, additional, Fang, Jing, additional, Galy-Fauroux, Isabelle, additional, Calderaro, Julien, additional, Shibuya, Akira, additional, Morizur, Severine, additional, Allaire, Manon, additional, Zucman-Rossi, Jessica, additional, Desdouets, Chantal, additional, and Couty, Jean-Pierre, additional

Published
2024
Full Text
View/download PDF

36. Molecular Subtypes and Gene Expression Signatures as Prognostic Features in Fully Resected Clear Cell Renal Cell Carcinoma: A Tailored Approach to Adjuvant Trials

Author

Roussel, Eduard, Verbiest, Annelies, Kinget, Lisa, Boeckx, Bram, Zucman-Rossi, Jessica, Couchy, Gabrielle, Caruso, Stefano, Job, Sylvie, de Reyniès, Aurélien, De Wever, Liesbeth, Baldewijns, Marcella, Van Poppel, Hendrik, Joniau, Steven, Lambrechts, Diether, Albersen, Maarten, and Beuselinck, Benoit

Published
2021
Full Text
View/download PDF

39. Telomere length is key to hepatocellular carcinoma diversity and telomerase addiction is an actionable therapeutic target

Author

Ningarhari, Massih, Caruso, Stefano, Hirsch, Théo Z., Bayard, Quentin, Franconi, Andrea, Védie, Anne-Laure, Noblet, Bénédicte, Blanc, Jean-Frédéric, Amaddeo, Giuliana, Ganne, Nathalie, Ziol, Marianne, Paradis, Valérie, Guettier, Catherine, Calderaro, Julien, Morcrette, Guillaume, Kim, Youngsoo, MacLeod, A. Robert, Nault, Jean-Charles, Rebouissou, Sandra, and Zucman-Rossi, Jessica

Published
2021
Full Text
View/download PDF

40. Circulating tumour DNA in patients with hepatocellular carcinoma across tumour stages and treatments.

Author

Campani, Claudia, Imbeaud, Sandrine, Couchy, Gabrielle, Ziol, Marianne, Hirsch, Theo Z., Rebouissou, Sandra, Noblet, Bénédicte, Nahon, Pierre, Hormigos, Katia, Sidali, Sabrina, Seror, Olivier, Taly, Valerie, Carrie, Nathalie Ganne, Laurent-Puig, Pierre, Zucman-Rossi, Jessica, and Nault, Jean-Charles

Subjects
CELL-free DNA, CIRCULATING tumor DNA, SOMATIC mutation, TELOMERASE reverse transcriptase, DNA analysis, HORMONE receptor positive breast cancer
Published
2024
Full Text
View/download PDF

41. BAP1 mutations define a homogeneous subgroup of hepatocellular carcinoma with fibrolamellar-like features and activated PKA

Author

Hirsch, Théo Z., Negulescu, Ana, Gupta, Barkha, Caruso, Stefano, Noblet, Bénédicte, Couchy, Gabrielle, Bayard, Quentin, Meunier, Léa, Morcrette, Guillaume, Scoazec, Jean-Yves, Blanc, Jean-Frédéric, Amaddeo, Giuliana, Nault, Jean-Charles, Bioulac-Sage, Paulette, Ziol, Marianne, Beaufrère, Aurélie, Paradis, Valérie, Calderaro, Julien, Imbeaud, Sandrine, and Zucman-Rossi, Jessica

Published
2020
Full Text
View/download PDF

42. Modeling a human hepatocellular carcinoma subset in mice through coexpression of met and point‐mutant β‐catenin

Author

Tao, Junyan, Xu, Emily, Zhao, Yifei, Singh, Sucha, Li, Xiaolei, Couchy, Gabrielle, Chen, Xin, Zucman‐Rossi, Jessica, Chikina, Maria, and Monga, Satdarshan PS

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Liver Cancer, Genetics, Rare Diseases, Digestive Diseases, Liver Disease, Cancer, 2.1 Biological and endogenous factors, Good Health and Well Being, Animals, Carcinoma, Hepatocellular, Gene Expression Regulation, Neoplastic, Liver Neoplasms, Male, Mice, Models, Biological, Point Mutation, Proto-Oncogene Proteins c-met, beta Catenin, Medical Biochemistry and Metabolomics, Clinical Sciences, Immunology, Gastroenterology & Hepatology, Clinical sciences
Abstract

Hepatocellular cancer (HCC) remains a significant therapeutic challenge due to its poorly understood molecular basis. In the current study, we investigated two independent cohorts of 249 and 194 HCC cases for any combinatorial molecular aberrations. Specifically we assessed for simultaneous HMET expression or hMet activation and catenin β1 gene (CTNNB1) mutations to address any concomitant Met and Wnt signaling. To investigate cooperation in tumorigenesis, we coexpressed hMet and β-catenin point mutants (S33Y or S45Y) in hepatocytes using sleeping beauty transposon/transposase and hydrodynamic tail vein injection and characterized tumors for growth, signaling, gene signatures, and similarity to human HCC. Missense mutations in exon 3 of CTNNB1 were identified in subsets of HCC patients. Irrespective of amino acid affected, all exon 3 mutations induced similar changes in gene expression. Concomitant HMET overexpression or hMet activation and CTNNB1 mutations were evident in 9%-12.5% of HCCs. Coexpression of hMet and mutant-β-catenin led to notable HCC in mice. Tumors showed active Wnt and hMet signaling with evidence of glutamine synthetase and cyclin D1 positivity and mitogen-activated protein kinase/extracellular signal-regulated kinase, AKT/Ras/mammalian target of rapamycin activation. Introduction of dominant-negative T-cell factor 4 prevented tumorigenesis. The gene expression of mouse tumors in hMet-mutant β-catenin showed high correlation, with subsets of human HCC displaying concomitant hMet activation signature and CTNNB1 mutations.ConclusionWe have identified cooperation of hMet and β-catenin activation in a subset of HCC patients and modeled this human disease in mice with a significant transcriptomic intersection; this model will provide novel insight into the biology of this tumor and allow us to evaluate novel therapies as a step toward precision medicine. (Hepatology 2016;64:1587-1605).

Published
2016

44. A gp130–Src–YAP module links inflammation to epithelial regeneration

Author

Taniguchi, Koji, Wu, Li-Wha, Grivennikov, Sergei I, de Jong, Petrus R, Lian, Ian, Yu, Fa-Xing, Wang, Kepeng, Ho, Samuel B, Boland, Brigid S, Chang, John T, Sandborn, William J, Hardiman, Gary, Raz, Eyal, Maehara, Yoshihiko, Yoshimura, Akihiko, Zucman-Rossi, Jessica, Guan, Kun-Liang, and Karin, Michael

Subjects
Biochemistry and Cell Biology, Biomedical and Clinical Sciences, Biological Sciences, Stem Cell Research - Nonembryonic - Non-Human, Cancer, Digestive Diseases, Regenerative Medicine, Stem Cell Research, 2.1 Biological and endogenous factors, 1.1 Normal biological development and functioning, Adaptor Proteins, Signal Transducing, Animals, Body Weight, Cell Cycle Proteins, Cell Differentiation, Cell Proliferation, Cytokine Receptor gp130, Disease Models, Animal, Enzyme Activation, Epithelial Cells, HEK293 Cells, Homeostasis, Humans, Inflammation, Inflammatory Bowel Diseases, Intestinal Mucosa, Mice, Phosphoproteins, Proto-Oncogene Proteins c-yes, Proto-Oncogene Proteins pp60(c-src), Receptors, Notch, Regeneration, Signal Transduction, Up-Regulation, YAP-Signaling Proteins, General Science & Technology
Abstract

Inflammation promotes regeneration of injured tissues through poorly understood mechanisms, some of which involve interleukin (IL)-6 family members, the expression of which is elevated in many diseases including inflammatory bowel diseases and colorectal cancer. Here we show in mice and human cells that gp130, a co-receptor for IL-6 cytokines, triggers activation of YAP and Notch, transcriptional regulators that control tissue growth and regeneration, independently of the gp130 effector STAT3. Through YAP and Notch, intestinal gp130 signalling stimulates epithelial cell proliferation, causes aberrant differentiation and confers resistance to mucosal erosion. gp130 associates with the related tyrosine kinases Src and Yes, which are activated on receptor engagement to phosphorylate YAP and induce its stabilization and nuclear translocation. This signalling module is strongly activated upon mucosal injury to promote healing and maintain barrier function.

Published
2015

45. Multi-site tumor sampling highlights molecular intra-tumor heterogeneity in malignant pleural mesothelioma

Author

Meiller, Clément, Montagne, François, Hirsch, Theo Z., Caruso, Stefano, de Wolf, Julien, Bayard, Quentin, Assié, Jean-Baptiste, Meunier, Léa, Blum, Yuna, Quetel, Lisa, Gibault, Laure, Pintilie, Ecaterina, Badoual, Cécile, Humez, Sarah, Galateau-Sallé, Françoise, Copin, Marie-Christine, Letouzé, Eric, Scherpereel, Arnaud, Zucman-Rossi, Jessica, Le Pimpec-Barthes, Françoise, Jaurand, Marie-Claude, and Jean, Didier

Published
2021
Full Text
View/download PDF

46. Hepatocellular carcinoma

Author

Llovet, Josep M., Kelley, Robin Kate, Villanueva, Augusto, Singal, Amit G., Pikarsky, Eli, Roayaie, Sasan, Lencioni, Riccardo, Koike, Kazuhiko, Zucman-Rossi, Jessica, and Finn, Richard S.

Published
2021
Full Text
View/download PDF

47. Plk1, upregulated by HIF-2, mediates metastasis and drug resistance of clear cell renal cell carcinoma

Author

Dufies, Maeva, Verbiest, Annelies, Cooley, Lindsay S., Ndiaye, Papa Diogop, He, Xingkang, Nottet, Nicolas, Souleyreau, Wilfried, Hagege, Anais, Torrino, Stephanie, Parola, Julien, Giuliano, Sandy, Borchiellini, Delphine, Schiappa, Renaud, Mograbi, Baharia, Zucman-Rossi, Jessica, Bensalah, Karim, Ravaud, Alain, Auberger, Patrick, Bikfalvi, Andréas, Chamorey, Emmanuel, Rioux-Leclercq, Nathalie, Mazure, Nathalie M., Beuselinck, Benoit, Cao, Yihai, Bernhard, Jean Christophe, Ambrosetti, Damien, and Pagès, Gilles

Published
2021
Full Text
View/download PDF

49. Clear-cell Renal Cell Carcinoma: Molecular Characterization of IMDC Risk Groups and Sarcomatoid Tumors

Author

Verbiest, Annelies, Renders, Inne, Caruso, Stefano, Couchy, Gabrielle, Job, Sylvie, Laenen, Annouschka, Verkarre, Virginie, Rioux-Leclercq, Nathalie, Schöffski, Patrick, Vano, Yann, Elaidi, Reza-Thierry, Lerut, Evelyne, Albersen, Maarten, Oudard, Stéphane, Fridman, Wolf-Hervé, Sautès-Fridman, Catherine, Albigès, Laurence, Wozniak, Agnieszka, Zucman-Rossi, Jessica, and Beuselinck, Benoit

Published
2019
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results