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1. Long-term alterations in brain and behavior after postnatal Zika virus infection in infant macaques

Author

Jessica Raper, Zsofia Kovacs-Balint, Maud Mavigner, Sanjeev Gumber, Mark W. Burke, Jakob Habib, Cameron Mattingly, Damien Fair, Eric Earl, Eric Feczko, Martin Styner, Sherrie M. Jean, Joyce K. Cohen, Mehul S. Suthar, Mar M. Sanchez, Maria C. Alvarado, and Ann Chahroudi

Subjects
Science
Abstract

The consequences of postnatal Zika infection are not fully understood. Here, the authors show that postnatal Zika infection in infant rhesus macaques alters neurodevelopment resulting in social, cognitive and motor impairments, as well as structural and functional changes in the brain.

Published
2020
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2. Ultrahigh-Sensitivity Capillary Electrophoresis Analysis of Trace Amounts of Nitrate and Nitrite in Environmental Water Samples

Author

Robert Farsang, Zsofia Kovacs, Gabor Jarvas, and Andras Guttman

Subjects
nitrate, nitrite, water samples, capillary electrophoresis, UV/VIS detection, limit of detection, Physics, QC1-999, Chemistry, QD1-999
Abstract

The role of nitrite (NO2−) and nitrate (NO3−) is essential in the global nitrogen cycle. Monitoring their concentration in environmental and industrial aqueous samples, surface water, soil, food and agricultural products are of high importance. Especially, the effect of anthropogenic emission, i.e., intensified agriculture is essential due to the overuse of nitrogen, phosphorus and potassium fertilizers. The most widely utilized methods for nitrate and nitrite determination are colorimetry, potentiometry, UV absorption and liquid chromatography. Among them, UV spectroscopy is the most frequently used technique due to the fact of its versatility and simplicity. However, there are industrial and academic needs to develop new methods to overcome some drawbacks of the currently used techniques such as an inadequate limit of detection and potential interferences with organic compounds in the sample. In this paper, we report on the development of a new analytical method based on capillary electrophoresis separation with high-sensitivity UV detection, capable of measuring trace concentrations of nitrite and nitrate well below the current limits of UV spectroscopy methods. During the development process special attention was paid to practical aspects, i.e., the method was tested to quantify nitrate and nitrite in various surface water samples.

Published
2022
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3. Prediction of extranodal extension in oropharyngeal cancer patients and carcinoma of unknown primary: value of metabolic tumor imaging with hybrid PET compared with MRI and CT

Author

Amina Nemmour, Thomas M. Stadler, Alexander Maurer, Zsofia Kovacs, Bettina Serrallach, Diana Born, Constanze M. Nemes, Martina A. Broglie, Shila Pazahr, Niels J. Rupp, Martin W. Hüllner, Sandro J. Stoeckli, Grégoire B. Morand, University of Zurich, and Stoeckli, Sandro J

Subjects
2733 Otorhinolaryngology, Otorhinolaryngology, 610 Medicine & health, 10045 Clinic for Otorhinolaryngology, 10181 Clinic for Nuclear Medicine, General Medicine
Published
2023

4. The Perception of Time in Edith Wharton’s The Age of Innocence (1920) in the Context of Her War-Related Nonfiction

Author

Agnes Zsofia Kovacs

Abstract

Edith Wharton published her The Age of Innocence just after the Great War, but the focus on the past and on social change in the text has usually not been connected to concerns in the novel’s immediate war context for a long time. However, as part of the general critical interest in the literature of war, the issue of the war context for The Age of Innocence was examined by Julie Olin-Ammentorp’s Edith Wharton’s Writings from the Great War in 2004. Hermione Lee’s subsequent biography of Wharton in 2008 also claimed that The Age was not only motivated by escapism but Wharton’s experience of war as well. This paper looks into how the perception of time is represented in Wharton’s nonfiction war text Fighting France (1915) and The Age of Innocence (1920) by comparing their representations of the contrast between the past and the present. Both Fighting France and The Age of Innocence contain spatial descriptions that employ Wharton’s rhetoric of what the article proposes to call “the presence of the past,” in which past moments reappear in the present, problematizing what is seen as real and unreal by the characters. The rhetoric of the presence of the past links the war text to the novel in that both share a basic interest in problematic processes of cultural continuity.

Published
2022

5. Heritability of social behavioral phenotypes and preliminary associations with autism spectrum disorder risk genes in rhesus macaques: A whole exome sequencing study

Author

Chris Gunter, R. Alan Harris, Zsofia Kovacs‐Balint, Muthuswamy Raveendran, Vasiliki Michopoulos, Jocelyne Bachevalier, Jessica Raper, Mar M. Sanchez, and Jeffrey Rogers

Subjects
Phenotype, Autism Spectrum Disorder, General Neuroscience, Exome Sequencing, Animals, Humans, Neurology (clinical), Social Behavior, Macaca mulatta, Article, Genetics (clinical)
Abstract

Nonhuman primates and especially rhesus macaques (Macaca mulatta) have been indispensable animal models for studies of various aspects of neurobiology, developmental psychology, and other aspects of neuroscience. While remarkable progress has been made in our understanding of influences on atypical human social behavior, such as that observed in autism spectrum disorders (ASD), many significant questions remain. Improved understanding of the relationships among variation in specific genes and variation in expressed social behavior in a nonhuman primate would benefit efforts to investigate risk factors, developmental mechanisms, and potential therapies for behavioral disorders including ASD. To study genetic influences on key aspects of social behavior and interactions-individual competence and/or motivation for specific aspects of social behavior-we quantified individual variation in social interactions among juvenile rhesus macaques using both a standard macaque ethogram and a macaque-relevant modification of the human Social Responsiveness Scale. Our analyses demonstrate that various aspects of juvenile social behavior exhibit significant genetic heritability, with estimated quantitative genetic effects similar to that described for ASD in human children. We also performed exome sequencing and analyzed variants in 143 genes previously suggested to influence risk for human ASD. We find preliminary evidence for genetic association between specific variants and both individual behaviors and multi-behavioral factor scores. To our knowledge, this is the first demonstration that spontaneous social behaviors performed by free-ranging juvenile rhesus macaques display significant genetic heritability and then to use exome sequencing data to examine potential macaque genetic associations in genes associated with human ASD.

Published
2022

6. Prediction of extranodal extension in oropharyngeal cancer patients and carcinoma of unknown primary: value of metabolic tumor imaging with hybrid PET compared with MRI and CT

Author

Amina, Nemmour, Thomas M, Stadler, Alexander, Maurer, Zsofia, Kovacs, Bettina, Serrallach, Diana, Born, Constanze M, Nemes, Martina A, Broglie, Shila, Pazahr, Niels J, Rupp, Martin W, Hüllner, Sandro J, Stoeckli, and Grégoire B, Morand

Abstract

The aim of this study was to investigate the value of metabolic tumor imaging using hybrid PET for the preoperative detection of extranodal extension (ENE) in lymph node metastases of oropharyngeal squamous cell carcinoma (OPSCC).We performed a retrospective analysis of a consecutive cohort of patients with OPSCC treated with primary surgery with or without adjuvant (chemo-) radiotherapy at the Kantonsspital Sankt-Gallen and the University Hospital Zurich, Switzerland, from 2010 until 2019. Hybrid PET was compared to conventional cross-sectional imaging with MRI and CT. Histopathological presence of ENE of neck dissection specimen served as gold standard.A total number of 234 patients were included in the study, 95 (40.6%) of which had pathological ENE (pENE). CT has a good specificity with 93.7%; meanwhile, MRI was the most sensitive diagnostic method (72.0%). The nodal metabolic tumor parameters (SUVCT achieved the best specificity, while MRI had the best sensitivity to detect ENE. Nodal metabolic tumor parameters differed significantly between ENE-positive/negative and p16-positive/negative patients. Hence, quantitative data obtained by metabolic imaging might predict presence of ENE and, therefore, could be helpful in customizing therapy management.

Published
2022

9. Focal unspecific bone uptake on [18F]-PSMA-1007 PET: a multicenter retrospective evaluation of the distribution, frequency, and quantitative parameters of a potential pitfall in prostate cancer imaging

Author

Klaus Strobel, Yannick Thali, Zsofia Kovacs, Joachim Müller, Alexander Maurer, Irene A. Burger, and Hannes Grünig

Subjects
Male, Niacinamide, Staging, Restaging, PET/CT, urologic and male genital diseases, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, Prostate cancer, 0302 clinical medicine, Text mining, Positron Emission Tomography Computed Tomography, medicine, Humans, Distribution (pharmacology), Radiology, Nuclear Medicine and imaging, Edetic Acid, Pelvis, Retrospective Studies, PET-CT, Tumor size, business.industry, Prostatic Neoplasms, Bone metastasis, General Medicine, Pet imaging, [18F]-PSMA, medicine.disease, PET/MR, medicine.anatomical_structure, Positron-Emission Tomography, 030220 oncology & carcinogenesis, Original Article, Tomography, X-Ray Computed, business, Nuclear medicine, Oligopeptides
Abstract

Purpose Improved logistics and availability led to a rapid increase in the use of [18F]-PSMA-1007 for prostate cancer PET imaging. Initial data suggests increased uptake in benign lesions compared to [68 Ga]-PSMA-11, and clinical observations found increased unspecific bone uptake (UBU). We therefore investigate the frequency and characteristics of UBU in [18F]-PSMA-1007 PET. Methods We retrospectively analyzed [18F]-PSMA-1007 PET scans from four centers for the presence of UBU, defined as a focal mild-to-moderate uptake (SUVmax max), localized, and correlated to clinical parameters, such as age, PSA, injected dose, Gleason score, tumor size (T1–T4), and type of PET scanner (analog vs. digital). Additionally, clinical and imaging follow-up results and therapeutic impact were evaluated. Results UBUs were identified in 179 out of 348 patients (51.4%). The most frequent localizations were ribs (57.5%) and pelvis (24.8%). The frequency of UBUs was not associated with PSA, Gleason score, tumor size, age, or the injected [18F]-PSMA-1007 dose. UBUs were significantly more frequent in images obtained with digital PET/CT scans (n = 74, 82%) than analog PET/CT scans (n = 221, 40.3%) (p = .0001) but not in digital PET/MR (n = 53, 51%) (p = .1599). In 80 out of 179 patients (44.7%), the interpretation of UBUs was critical for therapeutic management and therefore considered clinically relevant. For 65 UBUs, follow-ups were available: three biopsies, three radiotherapies with PSA follow-up, and 59 cases with imaging. After follow-up, UBUs were still considered unclear in 28 of 65 patients (43%), benign in 28 (43%), and malignant in nine (14%) patients. Conclusion UBUs occur in two-thirds of patients imaged with [18F]-PSMA-1007 PET/CT and are significantly more frequent on digital PET scanners than analog scanners. UBUs should be interpreted carefully to avoid over-staging.

Published
2021

11. Autoren

Author

Jürgen Behr, Sebastian Böing, Carl Crieé, Roland Diel, Wolfgang Frank, Björn C. Frye, Simon D. Herkenrath, Andreas Kirschbaum, Dieter Köhler, Zsofia Kovacs, Robert Loddenkemper, Volker Melichar, Joachim Müller-Quernheim, Georg Nilius, Winfried J. Randerath, Ernst Rietschel, Martin Rosewich, Bernhard Schaaf, Bernd Schönhofer, Patrick Schwarz, Martin Sebastian, Jan A. Stratmann, Anne Striegel, Christian Taube, Markus Unnewehr, Christian Viniol, Thomas Völkl, Ulrich Wagner, Alfred H. Wiater, Uwe Wintergerst, and Theodor Zimmermann

Published
2022

12. Contemporary Management of Severe Symptomatic Aortic Stenosis

Author

Marc Eugène, Piotr Duchnowski, Bernard Prendergast, Olaf Wendler, Cécile Laroche, Jean-Luc Monin, Yannick Jobic, Bogdan A. Popescu, Jeroen J. Bax, Alec Vahanian, Bernard Iung, Jeroen Bax, Michele De Bonis, Victoria Delgado, Michael Haude, Gerhard Hindricks, Aldo P. Maggioni, Luc Pierard, Susanna Price, Raphael Rosenhek, Frank Ruschitzka, Stephan Windecker, Souad Mekhaldi, Katell Lemaitre, Sébastien Authier, Magdy Abdelhamid, Astrid Apor, Gani Bajraktari, Branko Beleslin, Alexander Bogachev-Prokophiev, Daniela Cassar Demarco, Agnes Pasquet, Sait Mesut Dogan, Andrejs Erglis, Arturo Evangelista, Artan Goda, Nikolaj Ihlemann, Huseyin Ince, Andreas Katsaros, Katerina Linhartova, Julia Mascherbauer, Erkin Mirrakhimov, Vaida Mizariene, Shelley Rahman-Haley, Regina Ribeiras, Fuad Samadov, Antti Saraste, Iveta Simkova, Elizabeta Srbinovska Kostovska, Lidia Tomkiewicz-Pajak, Christophe Tribouilloy, Eliverta Zera, Mimoza Metalla, Ervina Shirka, Elona Dado, Loreta Bica, Jorida Aleksi, Gerti Knuti, Lidra Gjyli, Rudina Pjeci, Eritinka Shuperka, Erviola Lleshi, Joana Rustemaj, Marsjon Qordja, Mirald Gina, Senada Husi, Daniel Basic, Regina Steringer-Mascherbauer, Charlotte Huber, Christian Ebner, Elisabeth Sigmund, Andrea Ploechl, Thomas Sturmberger, Veronica Eder, Tanja Koppler, Maria Heger, Andreas Kammerlander, Franz Duca, Christina Binder, Matthias Koschutnik, Leonard Perschy, Lisa Puskas, Chen-Yu Ho, Farid Aliyev, Vugar Guluzada, Galib Imanov, Firdovsi Ibrahimov, Abbasali Abbasaliyev, Tahir Ahmedov, Fargana Muslumova, Jamil Babayev, Yasmin Rustamova, Tofig Jahangirov, Rauf Samadov, Muxtar Museyibov, Elnur Isayev, Oktay Musayev, Shahin Xalilov, Saleh Huseynov, Madina Yuzbashova, Vuqar Zamanov, Vusal Mammadov, Gery Van Camp, Martin Penicka, Hedwig Batjoens, Philippe Debonnaire, Daniel Dendooven, Sebastien Knecht, Mattias Duytschaever, Yves Vandekerckhove, Luc Missault, Luc Muyldermans, René Tavernier, Tineke De Grande, Patrick Coussement, Joyce DeTroyer, Katrien Derycker, Kelly De Jaegher, Antoine Bondue, Christophe Beauloye, Céline Goffinet, Daniela Corina Mirica, Frédéric Vanden Eynden, Philippe Van de Borne, Béatrice Van Frachen, David Vancraeynest, Jean Louis Vanoverschelde, Sophie Pierard, Mihaela Malanca, Florence Sinnaeve, Séverine Tahon, Marie De Clippel, Frederic Gayet, Jacques Loiseau, Nico Van de Veire, Veronique Moerman, Anne-Marie Willems, Bernard Cosyns, Steven Droogmans, Andreea Motoc, Dirk Kerkhove, Daniele Plein, Bram Roosens, Caroline Weytjens, Patrizio Lancellotti, Elena Raluca Dulgheru, Ilona Parenicova, Helena Bedanova, Frantisek Tousek, Stepanka Sindelarova, Julia Canadyova, Milos Taborsky, Jiri Ostransky, null Ivona simkova, Marek Vicha, Libor Jelinek, Irena Opavska, Miroslav Homza, Miriam Kvrayola, Radim Brat, Dan Mrozek, Eva Lichnerova, Iveta Docekalova, Marta Zarybnicka, Marketa Peskova, Patrik Roucka, Vlasta Stastna, Dagmar Jungwirtova Vondrackova, Alfred Hornig, Matus Niznansky, Marian Branny, Alexandra Vodzinska, Miloslav Dorda, Libor Snkouril, Krystyna Kluz, Jana Kypusova, Radka Nezvalova, Niels Thue Olsen, Hosam Hasan Ali, Salma Taha, Mohamed Hassan, Ahmed Afifi, Hamza Kabil, Amr Mady, Hany Ebaid, Yasser Ahmed, Mohammad Nour, Islam Talaat, CairoMaiy El Sayed, Ahmad Elsayed Mostafa, CairoYasser Sadek, CairoSherif Eltobgi, Sameh Bakhoum, Ramy Doss, Mahmoud Sheashea, Abd Allah Elasry, Ahmed Fouad, Mahmoud Baraka, Sameh Samir, Alaa Roshdy, Yasmin AbdelRazek, Mostafa M. Abd Rabou, Ahmed Abobakr, Moemen Moaaz, Mohamed Mokhtar, Mohamed Ashry, Khaled Elkhashab, Haytham Soliman Ghareeb, Mostafa Kamal, Gomaa AbdelRazek, GizaNabil Farag, Giza:Ahmed Elbarbary, Evette Wahib, Ghada Kazamel, Diaa Kamal, Mahmoud Tantawy, Adel Alansary, Mohammed Yahia, Raouf Mahmoud, Tamer El Banna, Mohamed Atef, Gamela Nasr, Salah Ahmed, Ehab E. El Hefny, Islam Saifelyazal, Mostafa Abd El Ghany, Abd El Rahman El Hadary, Ahmed Khairy, Jyri Lommi, Mika Laine, Minna Kylmala, Katja Kankanen, Anu Turpeinen, Juha Hartikainen, Lari Kujanen, Juhani Airaksinen, Tuija Vasankari, Catherine Szymanski, Yohann Bohbot, Mesut Gun, Justine Rousseaux, Loic Biere, Victor Mateus, Martin Audonnet, Jérémy Rautureau, Charles Cornet, Emmanuel Sorbets, BourgesKarine Mear, Adi Issa, Florent Le Ven, Marie-Claire Pouliquen, Martine Gilard, Alice Ohanessian, Ali Farhat, Alina Vlase, Fkhar Said, Caroline Lasgi, Carlos Sanchez, Romain Breil, Marc Peignon, Jean-Philippe Elkaim, Virginie Jan-Blin, Sylvain Ropars BertrandM'Ban, Hélène Bardet, Samuel Sawadogo, Aurélie Muschoot, Dieudonné Tchatchoua, Simon Elhadad, Aline Maubert, Tahar Lazizi, Kais Ourghi, Philippe Bonnet, Clarisse Menager-Gangloff, Sofiene Gafsi, Djidjiga Mansouri, Victor Aboyans, Julien Magne, Elie Martins, Sarah Karm, Dania Mohty, Guillaume Briday, Amandine David, Sylvestre Marechaux, Caroline Le Goffic, Camille Binda, Aymeric Menet, Francois Delelis, Anne Ringlé, Anne-Laure Castel, Ludovic Appert, Domitille Tristram, Camille Trouillet, Yasmine Nacer, Lucas Ngoy, MarseilleGilbert Habib, Franck Thuny, Julie Haentjens, Jennifer Cautela, Cécile Lavoute, Floriane Robin, Pauline Armangau, Ugo Vergeylen, Khalil Sanhadji, Nessim Hamed Abdallah, Hassan Kerzazi, Mariana Perianu, François Plurien, Chaker Oueslati, Mathieu Debauchez, Zannis Konstantinos, Alain Berrebi, Alain Dibie, Emmanuel Lansac, Aurélie Veugeois, Christelle Diakov, Christophe Caussin, Daniel Czitrom, Suzanna Salvi, Nicolas Amabile, Patrice Dervanian, Stéphanie Lejeune, Imane Bagdadi, Yemmi Mokrane, Gilles Rouault, Jerome Abalea, Marion Leledy, Patrice Horen, Erwan Donal, Christian Bosseau, Elise Paven, Elena Galli, Edouard Collette, Jean-Marie Urien, Valentin Bridonneau, Renaud Gervais, Fabrice Bauer, Houzefa Chopra, Arthur Charbonnier, David Attias, Nesrine Dahouathi, Moukda Khounlaboud, Magalie Daudin, Christophe Thebault, Cécile Hamon, Philippe Couffon, Catherine Bellot, Maelle Vomscheid, Anne Bernard, Fanny Dion, Djedjiga Naudin, Mohammed Mouzouri, Mathilde Rudelin, Alain Berenfeld, Thibault Vanzwaelmen, Tarik Alloui, Marija Gjerakaroska Radovikj, Slavica Jordanova, Werner Scholtz, Eva Liberda-Knoke, Melanie Wiemer, Andreas Mugge, Georg Nickenig, Jan-Malte Sinning, Alexander Sedaghat, Matthias Heintzen, Jan Ballof, Daniel Frenk, Rainer Hambrecht, Harm Wienbergen, Annemarie Seidel, Rico Osteresch, Kirsten Kramer, Janna Ziemann, Ramona Schulze, Wolfgang Fehske, Clarissa Eifler, Bahram Wafaisade, Andreas Kuhn, Sören Fischer, Lutz Lichtenberg, Mareike Brunold, Judith Simons, Doris Balling, Thomas Buck, Bjoern Plicht, Wolfgang Schols, Henning Ebelt, Marwan Chamieh, Jelena Anacker, Tienush Rassaf, Alexander Janosi, Alexander Lind, Julia Lortz, Peter Lüdike, Philipp Kahlert, Harald Rittger, Gabriele Eichinger, Britta Kuhls, Stephan B. Felix, Kristin Lehnert, Ann-Louise Pedersen, Marcus Dorr, Klaus Empen, Sabine Kaczmarek, Mathias Busch, Mohammed Baly, Fikret Er, Erkan Duman, Linda Gabriel, Christof Weinbrenner, Johann Bauersachs, Julian Wider, Tibor Kempf, Michael Bohm, Paul-Christian Schulze, C. Tudor Poerner, Sven Möbius-Winkler, Karsten Lenk, Kerstin Heitkamp, Marcus Franz, Sabine Krauspe, Burghard Schumacher, Volker Windmuller, Sarah Kurwitz, Holger Thiele, Thomas Kurz, Roza Meyer-Saraei, Ibrahim Akin, Christian Fastner, Dirk Lossnitzer, Ursula Hoffmann, Martin Borggrefe, Stefan Baumann, Brigitte Kircher, Claudia Foellinger, Heike Dietz, Bernhard Schieffer, Feraydoon Niroomand, Harald Mudra, Lars Maier, Daniele Camboni, Christoph Birner, Kurt Debl, Michael Paulus, Benedikt Seither, Nour Eddine El Mokhtari, Alper Oner, Evren Caglayan, Mohammed Sherif, Seyrani Yucel, Florian Custodis, Robert Schwinger, Marc Vorpahl, Melchior Seyfarth, Ina Nover, Till Koehler, Sarah Christiani, David Calvo Sanchez, Barbel Schanze, Holger Sigusch, Athir Salman, Jane Hancock, John Chambers, Camelia Demetrescue, Claire Prendergast, Miles Dalby, Robert Smith, Paula Rogers, Cheryl Riley, Dimitris Tousoulis, Ioannis Kanakakis, Konstantinos Spargias, Konstantinos Lampropoulos, Tolis Panagiotis, Athanasios Koutsoukis, Lampros Michalis, Ioannis Goudevenos, Vasileios Bellos, Michail Papafaklis, Lampros Lakkas, George Hahalis, Athanasios Makris, Haralampos Karvounis, Vasileios Kamperidis, Vlasis Ninios, Vasileios Sachpekidis, Pavlos Rouskas, Leonidas Poulimenos, Georgios Charalampidis, Eftihia Hamodraka, Athanasios Manolis, Robert Gabor Kiss, Tunde Borsanyi, Zoltan Jarai, Andras Zsary, Elektra Bartha, Annamaria Kosztin, Alexandra Doronina, Attila Kovacs, Barabas Janos Imre, Chun Chao, Kalman Benke, Istvan Karoczkai, Kati Keltai, Zsolt Förchécz, Zoltán Pozsonyi, Zsigmond Jenei, Adam Patthy, Laszlo Sallai, Zsuzsanna Majoros, Tamás Pál, Jusztina Bencze, Ildiko Sagi, Andrea Molnar, Anita Kurczina, Gabor Kolodzey, Istvan Edes, Valeria Szatmari, Zsuzsanna Zajacz, Attila Cziraki, Adam Nemeth, Reka Faludi, Laszlone Vegh, Eva Jebelovszki, Geza Karoly Lupkovics, Zsofia Kovacs, Andras Horvath, Gezim Berisha, Pranvera Ibrahimi, Luan Percuku, Rano Arapova, Elmira Laahunova, Kseniia Neronova, Zarema Zhakypova, Gulira Naizabekova, Gulnazik Muratova, Iveta Sime, Nikolajs Sorokins, Ginta Kamzola, Irina Cgojeva-Sproge, Gita Rancane, Ramune Valentinaviciene, Laima Rudiene, Rasa Raugaliene, Aiste Bardzilauske, Regina Jonkaitiene, Jurate Petrauskaite, Monika Bieseviciene, Raimonda Verseckaite, Ruta Zvirblyte, Danute Kalibatiene, Greta Radauskaite, Gabija Janaviciute-Matuzeviciene, Dovile Jancauskaite, Deimile Balkute, Juste Maneikyte, Ingrida Mileryte, Monika Vaisvilaite, Lina Gedvilaite, Mykolas Biliukas, Vaiva Karpaviciene, Robert George Xuereb, Elton Pllaha, Roxana Djaberi, Klaudiusz Komor, Agnieszka Gorgon-Komor, Beata Loranc, Jaroslaw Myszor, Katarzyna Mizia-Stec, Adrianna Berger-Kucza, Magdalena Mizia, Mateusz Polak, Piotr Bogacki, Piotr Podolec, Monika Komar, Ewa Sedziwy, Dorota Sliwiak, Bartosz Sobien, Beata Rog, Marta Hlawaty, Urszula Gancarczyk, Natasza Libiszewska, Danuta Sorysz, Andrzej Gackowski, Malgorzata Cieply, Agnieszka Misiuda, Franciszek Racibor, Anna Nytko, Kazimierz Widenka, Maciej Kolowca, Janusz Bak, Andrzej Curzytek, Mateusz Regulski, Malgorzata Kamela, Mateusz Wisniowski, Tomasz Hryniewiecki, Piotr Szymanski, Monika Rozewicz, Maciej Grabowski, Andrzej Budaj, Beata Zaborska, Ewa Pilichowska-Paskiet, Malgorzata Sikora-Frac, Tomasz Slomski, Isabel Joao, Ines Cruz, Hélder Pereira, Rita Cale, Ana Marques, Ana Rita Pereira, Carlos Morais, Antonio Freitas, David Roque, Nuno Antunes, Antonio Costeira Pereira, Catarina Vieira, Nuno Salome, Juliana Martins, Isabel Campos, Goncalo Cardoso, Claudia Silva, Afonso Oliveira, Mariana Goncalves, Rui Martins, Nuno Quintal, Bruno Mendes, Joseline Silva, Joao Ferreira, James Milner, Patricia Alves, Vera Marinho, Paula Gago, Jose Amado, Joao Bispo, Dina Bento, Inocencia Machado, Margarida Oliveira, Lucy Calvo, Pedro von Hate, Bebiana Faria, Ana Galrinho, Luisa Branco, Antonio Goncalves, Tiago Mendonca, Mafalda Selas, Filipe Macedo, Carla Sousa, Sofia Cabral, Filomena Oliveira, Maria Trepa, Marta Fontes-Oliveira, Alzira Nunes, Paulo Araújo, Vasco Gama Ribeiro, Joao Almeida, Alberto Rodrigues, Pedro Braga, Sonia Dias, Sofia Carvalho, Catarina Ferreira, Alberto Ferreira, Pedro Mateus, Miguel Moz, Silvia Leao, Renato Margato, Ilidio Moreira, Jose Guimanaes, Joana Ribeiro, Fernando Goncalves, Jose Cabral, Ines Almeida, Luisa Goncalves, Mariana Tarusi, Calin Pop, Claudia Matei, Diana Tint, Sanziana Barbulescu, Sorin Micu, Ioana Pop, Costica Baba, Doina Dimulescu, Maria Dorobantu, Carmen Ginghina, Roxana Onut, Andreea Popescu, Brandusa Zamfirescu, Raluca Aflorii, Mihaela Popescu, Liviu Ghilencea, Andreeea Rachieru, Monica Stoian, Nicoleta Oprescu, Silvia Iancovici, Iona Petre, Anca Doina Mateescu, Andreea Calin, Simona Botezatu, Roxana Enache, Monica Rosca, Daniela Ciuperca, Evelyn Babalac, Ruxandra Beyer, Laura Cadis, Raluca Rancea, Raluca Tomoaia, Adela Rosianu, Emese Kovacs, Constantin Militaru, Alina Craciun, Oana Mirea, Mihaela Florescu, Lucica Grigorica, Daniela Dragusin, Luiza Nechita, Mihai Marinescu, Teodor Chiscaneanu, Lucia Botezatu, Costela Corciova, Antoniu Octavian Petris, Catalina Arsenescu-Georgescu, Delia Salaru, Dan Mihai Alexandrescu, Carmjen Plesoianu, Ana Tanasa, Ovidiu Mitu, Irina Iuliana Costache, Ionut Tudorancea, Catalin Usurelu, Gabriela Eminovici, Ioan Manitiu, Oana Stoia, Adriana Mitre, Dan-Octavian Nistor, Anca Maier, Silvia Lupu, Mihaela Opris, Adina Ionac, Irina Popescu, Simina Crisan, Cristian Mornos, Flavia Goanta, Liana Gruescu, Oana Voinescu, Madalina Petcu, Ramona Cozlac, Elena Damrina, Liliya Khilova, Irina Ryazantseva, Dmitry Kozmin, Maria Kiseleva, Marina Goncharova, Kamila Kitalaeva, Victoria Demetskay, Artem Verevetinov, Mikhail Fomenko, Elena Skripkina, Viktor Tsoi, Georgii Antipov, Yuri Schneider, Denis Yazikov, Marina Makarova, Aleksei Cherkes, Natalya Ermakova, Aleksandr Medvedev, Anastasia Sarosek, Mikhail Isayan, Tatyana Voronova, Oleg Kulumbegov, Alina Tuchina, Sergei Stefanov, Margarita Klimova, Konstantin Smolyaninov, Zhargalma Dandarova, Victoriya Magamet, Natalia Spiropulos, Sergey Boldyrev, Kirill Barbukhatty, Dmitrii Buyankov, Vladimir Yurin, Yuriy Gross, Maksim Boronin, Mariya Mikhaleva, Mariya Shablovskaya, Alex Zotov, Daniil Borisov, Vasily Tereshchenko, Ekaterina Zubova, A. Kuzmin, Ivan Tarasenko, Alishir Gamzaev, Natalya Borovkova, Tatyana Koroleva, Svetlana Botova, Ilya Pochinka, Vera Dunaeva, Victoria Teplitskaya, Elena I. Semenova, Olga V. Korabel'Nikova, Denis S. Simonov, Elena Denisenko, Natalia Harina, Natalia Yarohno, Svetlana Alekseeva, Julia Abydenkova, Lyubov Shabalkina, Olga Mayorova, Valeriy Tsechanovich, Igor Medvedev, Michail Lepilin, PenzaEvgenii Nemchenko, Vadim Karnahin, Vasilya Safina, Yaroslav Slastin, Venera Gilfanova, Roman Gorbunov, Ramis Jakubov, Aigul Fazylova, Mansur Poteev, Laysan Vazetdinova, Indira Tarasova, Rishat Irgaliyev, Olga Moiseeva, Mikhail Gordeev, Olga Irtyuga, Raisa Moiseeva, Nina Ostanina, Dmitry Zverev, Patimat Murtazalieva, Dmitry Kuznetsov, Mariya Skurativa, Larisa Polyaeva, Kirill Mihaiilov, Biljana Obrenovic-Kircanski, Svetozar Putnik, Dragan Simic, Milan Petrovic, Natasa Markovic Nikolic, Ljiljana Jovovic, Dimitra Kalimanovska Ostric, Milan Brajovic, Milica Dekleva Manojlovic, Vladimir Novakovic, Danijela Zamaklar-Trifunovic, Bojana Orbovic, Olga Petrovic, Marija Boricic-Kostic, Kristina Andjelkovic, Marko Milanov, Maja Despotovic-Nikolic, Sreten Budisavljevic, Sanja Veljkovic, Nataša Cvetinovic, Daniijela Lepojevic, Aleksandra Todorovic, Aleksandra Nikolic, Branislava Borzanovic, Ljiljana Trkulja, Slobodan Tomic, Milan Vukovic, Jelica Milosavljevic, Mirjana Milanovic, Vladan Stakic, Aleksandra Cvetkovic, Suzana Milutinovic, Olivera Bozic, Miodrag Miladinovic, Zoran Nikolic, Dinka Despotovic, Dimitrije Jovanovic, Anastazija Stojsic-Milosavljevic, Aleksandra Ilic, Mirjana Sladojevic, Stamenko Susak, Srdjan Maletin, Salvo Pavlovic, Vladimir Kuzmanovic, Nikola Ivanovic, Jovana Dejanovic, Dusan Ruzicic, Dragana Drajic, Danijel Cvetanovic, Marija Mirkovic, Jon Omoran, Roman Margoczy, Katarina Sedminova, Adriana Reptova, Eva Baranova, Tatiana Valkovicova, Gabriel Valocik, Marian Kurecko, Marianna Vachalcova, Alzbeta Kollarova, Martin Studencan, Daniel Alusik, Marek Kozlej, Jana Macakova, Sergio Moral, Merce Cladellas, Daniele Luiso, Alicia Calvo, Jordi Palet, Juli Carballo, Gisela Teixido Tura, Giuliana Maldonado, Laura Gutierrez, Teresa Gonzalez-Alujas, Rodriguez Palomares Jose Fernando, Nicolas Villalva, Ma Jose Molina-Mora, Ramon Rubio Paton, Juan Jose Martinez Diaz, Pablo Ramos Ruiz, Alfonso Valle, Ana Rodriguez, Edgardo Alania, Emilio Galcera, Julia Seller, Gonzalo de la Morena Valenzuela, Daniel Saura Espin, Dolores Espinosa Garcia, Maria Jose Oliva Sandoval, Josefa Gonzalez, Miguel Garcia Navarro, Maria Teresa Perez-Martinez, Jose Ramon Ortega Trujillo, Irene Menduina Gallego, Daniel San Roman, Eliu David Perez Nogales, Olga Medina, Rodolfo Antonio Montiel Quintero, Pablo Felipe Bujanda Morun, Marta Lopez Perez, Jimmy Plasencia Huaripata, Juan Jose Morales Gonzalez, Veronica Quevedo Nelson, Jose Luis Zamorano, Ariana Gonzalez Gomez, Alfonso Fraile, Maria Teresa Alberca, Joaquin Alonso Martin, Covadonga Fernandez-Golfin, Javier Ramos, Sergio Hernandez Jimenez, Cristina Mitroi, Pedro L. Sanchez Fernandez, Elena Diaz-Pelaez, Beatriz Garde, Luis Caballero, Fermin Martinez Garcia, Francisco Cambronero, Noelia Castro, Antonio Castro, Alejandro De La Rosa, Pastora Gallego, Irene Mendez, David Villagomez Villegas, Manuel Gonzalez Correa, Roman Calvo, Francisco Florian, Rafael Paya, Esther Esteban, Francisco Buendia, Andrés Cubillos, Carmen Fernandez, Juan Pablo Cárdenas, José Leandro Pérez-Boscá, Joan Vano, Joaquina Belchi, Cristina Iglesia-Carreno, Francisco Calvo Iglesias, Aida Escudero-Gonzalez, Sergio Zapateria-Lucea, Juan Sterling Duarte, Lara Perez-Davila, Rafael Cobas-Paz, Rosario Besada-Montenegro, Maribel Fontao-Romeo, Elena Lopez-Rodriguez, Emilio Paredes-Galan, Berenice Caneiro-Queija, Alba Guitian Gonzalez, Abdi Bozkurt, Serafettin Demir, Durmus Unlu, Caglar Emre Cagliyan, Muslum Firat Ikikardes, Mustafa Tangalay, Osman Kuloglu, Necla Ozer, Ugur Canpolat, Melek Didem Kemaloglu, Abdullah Orhan Demirtas, Didar Elif Akgün, Eyup Avci, Gokay Taylan, Mustafa Adem Yilmaztepe, Fatih Mehmet Ucar, Servet Altay, Muhammet Gurdogan, Naile Eris Gudul, Mujdat Aktas, Mutlu Buyuklu, Husnu Degirmenci, Mehmet Salih Turan, Kadir Ugur Mert, Gurbet Ozge Mert, Muhammet Dural, Sukru Arslan, Nurten Sayar, Batur Kanar, Beste Ozben Sadic, Ahmet Anil Sahin, Ahmet Buyuk, Onur Kilicarslan, Cem Bostan, Tarik Yildirim, Seda Elcim Yildirim, Kahraman Cosansu, Perihan Varim, Ersin Ilguz, Recep Demirbag, Asuman Yesilay, Abdullah Cirit, Eyyup Tusun, Emre Erkus, Muhammet Rasit Sayin, Zeynep Kazaz, Selim Kul, Turgut Karabag, Belma Kalayci, Clinical sciences, Cardio-vascular diseases, and Cardiology

Subjects
Male, medicine.medical_specialty, Multivariate analysis, Clinical Decision-Making, Risk Assessment, Severity of Illness Index, decision making, surgery, Risk Factors, Internal medicine, Intervention (counseling), medicine, Clinical endpoint, Humans, 03.02. Klinikai orvostan, guidelines, Symptomatic aortic stenosis, Aged, Retrospective Studies, Aged, 80 and over, business.industry, valvular heart disease, Disease Management, aortic stenosis, Aortic Valve Stenosis, Odds ratio, medicine.disease, Europe, Stenosis, Treatment Outcome, Echocardiography, Aortic Valve, Charlson comorbidity index, transcatheter aortic valve replacement, Female, Morbidity, Cardiology and Cardiovascular Medicine, business, Follow-Up Studies, surgical aortic valve replacement
Abstract

BACKGROUND There were gaps between guidelines and practice when surgery was the only treatment for aortic stenosis (AS). OBJECTIVES This study analyzed the decision to intervene in patients with severe AS in the EORP VHD (EURObservational Research Programme Valvular Heart Disease) II survey. METHODS Among 2,152 patients with severe AS, 1,271 patients with high-gradient AS who were symptomatic fulfilled a Class I recommendation for intervention according to the 2012 European Society of Cardiology guidelines; the primary end point was the decision for intervention. RESULTS A decision not to intervene was taken in 262 patients (20.6%). In multivariate analysis, the decision not to intervene was associated with older age (odds ratio [OR]: 1.34 per 10-year increase; 95% CI: 1.11 to 1.61; P = 0.002), New York Heart Association functional classes I and II versus III (OR: 1.63; 95% CI: 1.16 to 2.30; P = 0.005), higher age adjusted Charlson comorbidity index (OR: 1.09 per 1-point increase; 95% CI: 1.01 to 1.17; P = 0.03), and a lower transaortic mean gradient (OR: 0.81 per 10-mm Hg decrease; 95% CI: 0.71 to 0.92; P < 0.001). During the study period, 346 patients (40.2%, median age 84 years, median EuroSCORE II [European System for Cardiac Operative Risk Evaluation II] 3.1%) underwent transcatheter intervention and 515 (59.8%, median age 69 years, median EuroSCORE II 1.5%) underwent surgery. A decision not to intervene versus intervention was associated with lower 6-month survival (87.4%; 95% CI: 82.0 to 91.3 vs 94.6%; 95% CI: 92.8 to 95.9; P < 0.001). CONCLUSIONS A decision not to intervene was taken in 1 in 5 patients with severe symptomatic AS despite a Class I recommendation for intervention and the decision was particularly associated with older age and combined comorbidities. Transcatheter intervention was extensively used in octogenarians. (J Am Coll Cardiol 2021;78:2131-2143) (c) 2021 by the American College of Cardiology Foundation.

Published
2021

13. Structural development of cortical lobes during the first 6 months of life in infant macaques

Author

Zsofia Kovacs-Balint, Martin Styner, Christa Payne, Mar M. Sanchez, Ling Li, J. Steele, and Jocelyne Bachevalier

Subjects
Male, Neurophysiology and neuropsychology, Cognitive Neuroscience, Posterior parietal cortex, Macaque, 050105 experimental psychology, 03 medical and health sciences, Typically developing, 0302 clinical medicine, biology.animal, Intracranial volume, Animals, 0501 psychology and cognitive sciences, Cortical lobes, Original Research, Cerebral Cortex, Brain Mapping, biology, QP351-495, 05 social sciences, Anatomy, Macaca mulatta, Magnetic Resonance Imaging, Temporal Lobe, Nonhuman primate, Infant brain development, Structural MRI, Brain growth, Nonhuman primate model, Rhesus monkey, Brain developmental patterns, Psychology, Occipital lobe, 030217 neurology & neurosurgery, Temporal Cortices
Abstract

This study mapped the developmental trajectories of cortical regions in comparison to overall brain growth in typically developing, socially-housed infant macaques. Volumetric changes of cortical brain regions were examined longitudinally between 2-24 weeks of age (equivalent to the first 2 years in humans) in 21 male rhesus macaques. Growth of the prefrontal, frontal, parietal, occipital, and temporal cortices (visual and auditory) was examined using MRI and age-specific infant macaque brain atlases developed by our group. Results indicate that cortical volumetric development follows a cubic growth curve, but maturational timelines and growth rates are region-specific. Total intracranial volume (ICV) increased significantly during the first 5 months of life, leveling off thereafter. Prefrontal and temporal visual cortices showed fast volume increases during the first 16 weeks, followed by a plateau, and significant growth again between 20-24 weeks. Volume of the frontal and temporal auditory cortices increased substantially between 2-24 weeks. The parietal cortex showed a significant volume increase during the first 4 months, whereas the volume of the occipital lobe increased between 2-12 weeks and plateaued thereafter. These developmental trajectories show similarities to cortical growth in human infants, providing foundational information necessary to build nonhuman primate (NHP) models of human neurodevelopmental disorders.

Published
2021

14. Developmental outcomes of early adverse care on amygdala functional connectivity in nonhuman primates

Author

Eric Earl, Eric Feczko, Zsofia Kovacs-Balint, Elyse L. Morin, Brittany R. Howell, Jerrold S. Meyer, Melanie Pincus, Katherine M. Reding, Mar M. Sanchez, Martin Styner, and Damien A. Fair

Subjects
Primates, Adolescent, Prefrontal Cortex, Macaque, Amygdala, 050105 experimental psychology, Arousal, 03 medical and health sciences, 0302 clinical medicine, Pregnancy, biology.animal, Neural Pathways, Developmental and Educational Psychology, medicine, Animals, Humans, 0501 psychology and cognitive sciences, Prefrontal cortex, Child, biology, Functional connectivity, 05 social sciences, Brain, Magnetic Resonance Imaging, Cortex (botany), Psychiatry and Mental health, medicine.anatomical_structure, nervous system, Locus coeruleus, Female, Psychology, Neuroscience, 030217 neurology & neurosurgery, Psychopathology
Abstract

Despite the strong link between childhood maltreatment and psychopathology, the underlying neurodevelopmental mechanisms are poorly understood and difficult to disentangle from heritable and prenatal factors. This study used a translational macaque model of infant maltreatment in which the adverse experience occurs in the first months of life, during intense maturation of amygdala circuits important for stress and emotional regulation. Thus, we examined the developmental impact of maltreatment on amygdala functional connectivity (FC) longitudinally, from infancy through the juvenile period. Using resting state functional magnetic resonance imaging (MRI) we performed amygdala–prefrontal cortex (PFC) region-of-interest and exploratory whole-brain amygdala FC analyses. The latter showed (a) developmental increases in amygdala FC with many regions, likely supporting increased processing of socioemotional-relevant stimuli with age; and (b) maltreatment effects on amygdala coupling with arousal and stress brain regions (locus coeruleus, laterodorsal tegmental area) that emerged with age. Maltreated juveniles showed weaker FC than controls, which was negatively associated with infant hair cortisol concentrations. Findings from the region-of-interest analysis also showed weaker amygdala FC with PFC regions in maltreated animals than controls since infancy, whereas bilateral amygdala FC was stronger in maltreated animals. These effects on amygdala FC development may underlie the poor behavioral outcomes associated with this adverse experience.

Published
2021

15. The Memory of Architecture in Edith Wharton’s Travel Writings

Author

Ágnes Zsófia Kovács and Ágnes Zsófia Kovács

Abstract

Edith Wharton was not only the author of novels and short stories but also of drama, poetry, autobiography, interior decoration, and travel writing. This study focuses on Wharton's symbolic representations of architecture in her travel writings. It shows how a network of allusions to travel writing and art history books influenced Wharton's representations of architectural and natural spaces. The book demonstrates Wharton's complex relationship to works of art historians (John Ruskin, Émile Mâle, Arthur C. Porter) and travel authors (Wolfgang Goethe, Henry Adams, Henry James) in the trajectory of her travel writing. Kovács surveys how the acknowledgment of Wharton's sources sheds light both on the author's model of aesthetic understanding and scenic architectural descriptions, and how the shock of the Great War changed Wharton's travel destinations but not her symbolic view of architecture as a mediator of things past. Wharton's symbolic representations of architecture provide a new key to her travel writings.

Published
2024

16. Systematic review: pain, cognition, and cardioprotection—unpacking oxytocin’s contributions in a sport context

Author

Péter Szabó, Sara Bonet, Roland Hetényi, Dániel Hanna, Zsófia Kovács, Gyöngyvér Prisztóka, Zuzana Križalkovičová, and József Szentpéteri

Subjects
cardioprotection, cognition, exercise, measurement, oxytocin, pain, Physiology, QP1-981
Abstract

IntroductionThis systematic review investigates the interplay between oxytocin and exercise; in terms of analgesic, anti-inflammatory, pro-regenerative, and cardioprotective effects. Furthermore, by analyzing measurement methods, we aim to improve measurement validity and reliability.MethodsUtilizing PRISMA, GRADE, and MECIR protocols, we examined five databases with a modified SPIDER search. Including studies on healthy participants, published within the last 20 years, based on keywords “oxytocin,” “exercise” and “measurement,” 690 studies were retrieved initially (455 unique records). After excluding studies of clinically identifiable diseases, and unpublished and reproduction-focused studies, 175 studies qualified for the narrative cross-thematic and structural analysis.ResultsThe analysis resulted in five categories showing the reciprocal impact of oxytocin and exercise: Exercise (50), Physiology (63), Environment (27), Social Context (65), and Stress (49). Exercise-induced oxytocin could promote tissue regeneration, with 32 studies showing its analgesic and anti-inflammatory effects, while 14 studies discussed memory and cognition. Furthermore, empathy-associated OXTR rs53576 polymorphism might influence team sports performance. Since dietary habits and substance abuse can impact oxytocin secretion too, combining self-report tests and repeated salivary measurements may help achieve precision.DiscussionOxytocin’s effect on fear extinction and social cognition might generate strategies for mental training, and technical, and tactical development in sports. Exercise-induced oxytocin can affect the amount of stress experienced by athletes, and their response to it. However, oxytocin levels could depend on the type of sport in means of contact level, exercise intensity, and duration. The influence of oxytocin on athletes’ performance and recovery could have been exploited due to its short half-life. Examining oxytocin’s complex interactions with exercise paves the way for future research and application in sports science, psychology, and medical disciplines.Systematic Review Registration:https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=512184, identifier CRD42024512184

Published
2024
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18. Sequence diversity analyses of an improved rhesus macaque genome enhances its biomedical utility

Author

David H. O’Connor, Flavia Angela Maria Maggiolini, Claudia Rita Catacchio, Louis J. Picker, Nicholas Maurer, Jason G. Underwood, Jeffrey Rogers, Mitchell R. Vollger, Mark A. Batzer, Jeffrey A. Roberts, Ashley D. Sanders, Katherine M. Munson, Jessica M. Storer, Merly Escalona, Jon E. Levine, Muthuswamy Raveendran, Mario Ventura, Jason D Fernandes, Jan O. Korbel, Joseph W. Kemnitz, R. Alan Harris, Evan E. Eichler, Douglas L. Rosene, Shwetha C. Murali, Mark Diekhans, David Gordon, David Porubsky, Philip C. Dishuck, Erin L. Kinnally, LaDeana W. Hillier, Betsy Ferguson, Joel Armstrong, Chad Tomlinson, Zsofia Kovacs-Balint, Sara M Thomasy, Tina A. Graves-Lindsay, Roger W. Wiseman, Michael L. Platt, Peter A. Audano, Jerilyn A. Walker, Ian T. Fiddes, Benedict Paten, Elizabeth Devogelaere, David H. Abbott, J. H. Pate Skene, Marina Haukness, Mar M. Sanchez, Ned H. Kalin, Milinn Kremitzki, Alexandra P. Lewis, Francesca Antonacci, H. Michael Kubisch, Richard E. Green, John P. Capitanio, Yafei Mao, Sofie R. Salama, Ludovica Mercuri, Wesley C. Warren, Shelley A. Cole, and Stanton B. Gray

Subjects
Whole genome sequencing, Multidisciplinary, Genome, Contig, Whole Genome Sequencing, Genetic Variation, Molecular Sequence Annotation, Computational biology, Biology, biology.organism_classification, Macaca mulatta, Polymorphism, Single Nucleotide, Article, Rhesus macaque, Gene family, Animals, Humans, Genetic Predisposition to Disease, Indel, Reference genome, Segmental duplication
Abstract

A high-quality rhesus macaque genome Genome technology has improved substantially since the first full organismal genomes were generated. Applying new technology, Warren et al. refined the genome of the rhesus macaque, a model nonhuman primate. Long-read technology and other recent advances in sequencing technology were applied to generate a genome with far fewer gaps and helped to refine the locations and numbers of repetitive elements. Furthermore, the authors performed resequencing among populations to identify the genetic variability of the rhesus macaque. Thus, a previously incomplete and inaccurate set of sequence information is now fully resolved, improving gene mapping for biomedical and comparative genetic studies. Science , this issue p. eabc6617

Published
2020

20. Prediction of Physico-Chemical Parameters of Surface Waters Using Autoregressive Moving Average Models: A Case Study of Kis-Balaton Water Protection System, Hungary

Author

Zsófia Kovács, Bálint Levente Tarcsay, Piroska Tóth, Csenge Judit Juhász, Sándor Németh, and Amin Shahrokhi

Subjects
water quality, continuous monitoring, sensors, time series regression, Hydraulic engineering, TC1-978, Water supply for domestic and industrial purposes, TD201-500
Abstract

In this work, the authors provide a case study of time series regression techniques for water quality forecasting. With the constant striving to achieve the Sustainable Development Goals (SDG), the need for sensitive and reliable water management tools has become critical. Continuous online surface water quality monitoring systems that record time series data about surface water parameters are essential for the supervision of water conditions and proper water management practices. The time series data obtained from these systems can be used to develop mathematical models for the prediction of the temporal evolution of water quality parameters. Using these mathematical models, predictions can be made about future trends in water quality to pinpoint irregular behaviours in measured data and identify the presence of anomalous events. We compared the performance of regression models with different structures for the forecasting of water parameters by utilizing a data set collected from the Kis-Balaton Water Protection System (KBWPS) wetland region of Hungary over an observation period of eleven months as a case study. In our study, autoregressive integrated moving average (ARIMA) regression models with different structures have been compared based on forecasting performance. Using the resulting models, trends of the oxygen saturation, pH level, electrical conductivity, and redox potential of the water could be accurately forecast (validation data residual standard deviation between 0.09 and 20.8) while in the case of turbidity, only averages of future values could be predicted (validation data residual standard deviation of 56.3).

Published
2024
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21. Long-term alterations in brain and behavior after postnatal Zika virus infection in infant macaques

Author

Damien A. Fair, Ann Chahroudi, Martin Styner, Jakob Habib, Maria C. Alvarado, Eric Earl, Joyce Cohen, Carmen Mattingly, Eric Feczko, Mark W. Burke, Mar M. Sanchez, Mehul S. Suthar, Zsofia Kovacs-Balint, Sherrie Jean, Maud Mavigner, Sanjeev Gumber, and Jessica Raper

Subjects
0301 basic medicine, Nervous system, Cerebellum, Science, General Physics and Astronomy, Hippocampus, Neuroimaging, Amygdala, Article, General Biochemistry, Genetics and Molecular Biology, Zika virus, 03 medical and health sciences, Lateral ventricles, Cognition, 0302 clinical medicine, Memory, Virology, Animals, Medicine, lcsh:Science, Social Behavior, 030304 developmental biology, 0303 health sciences, Multidisciplinary, biology, Disease model, Zika Virus Infection, business.industry, Developmental disorders, Brain, Zika Virus, General Chemistry, biology.organism_classification, Macaca mulatta, 3. Good health, Disease Models, Animal, Rhesus macaque, 030104 developmental biology, medicine.anatomical_structure, lcsh:Q, Female, Nerve Net, business, Neuroscience, 030217 neurology & neurosurgery
Abstract

Zika virus (ZIKV) infection has a profound impact on the fetal nervous system. The postnatal period is also a time of rapid brain growth, and it is important to understand the potential neurobehavioral consequences of ZIKV infection during infancy. Here we show that postnatal ZIKV infection in a rhesus macaque model resulted in long-term behavioral, motor, and cognitive changes, including increased emotional reactivity, decreased social contact, loss of balance, and deficits in visual recognition memory at one year of age. Structural and functional MRI showed that ZIKV-infected infant rhesus macaques had persistent enlargement of lateral ventricles, smaller volumes and altered functional connectivity between brain areas important for socioemotional behavior, cognitive, and motor function (e.g. amygdala, hippocampus, cerebellum). Neuropathological changes corresponded with neuroimaging results and were consistent with the behavioral and memory deficits. Overall, this study demonstrates that postnatal ZIKV infection in this model may have long-lasting neurodevelopmental consequences., The consequences of postnatal Zika infection are not fully understood. Here, the authors show that postnatal Zika infection in infant rhesus macaques alters neurodevelopment resulting in social, cognitive and motor impairments, as well as structural and functional changes in the brain.

Published
2020

22. Obesogenic Diet-Associated C-Reactive Protein Predicts Reduced Central Dopamine and Corticostriatal Functional Connectivity in Female Rhesus Monkeys

Author

Oscar Miranda-Dominguez, Jason L. Locke, Melanie Pincus, Mar M. Sanchez, Eric Earl, Zsofia Kovacs-Balint, Jodi R. Godfrey, Sara R. Jones, Vasiliki Michopoulos, Eric Feczko, Damien A. Fair, and Mark E. Wilson

Subjects
0301 basic medicine, medicine.medical_specialty, Dopamine, Immunology, Nucleus accumbens, Article, Nucleus Accumbens, 03 medical and health sciences, Behavioral Neuroscience, chemistry.chemical_compound, 0302 clinical medicine, Reward, Internal medicine, Medicine, Animals, Prefrontal cortex, biology, Endocrine and Autonomic Systems, business.industry, Homovanillic acid, Dopaminergic, C-reactive protein, Acute-phase protein, Macaca mulatta, Diet, 030104 developmental biology, Endocrinology, C-Reactive Protein, chemistry, biology.protein, Orbitofrontal cortex, Female, business, 030217 neurology & neurosurgery, medicine.drug
Abstract

Alterations in dopamine (DA) signaling and reductions in functional connectivity (FC; a measure of temporal correlations of activity between different brain regions) within dopaminergic reward pathways are implicated in the etiology of psychopathology and have been associated with increased concentrations of inflammatory markers, including C-reactive protein. Peripheral and central inflammatory cytokines that have been shown to disrupt DA signaling and corticostriatal FC are associated with C-reactive protein, an acute phase reactant that is used translationally as a marker of systemic inflammation. One factor that can significantly increase systemic inflammation to produce neuroadaptations in reward pathways is a diet that results in fat mass accumulation (e.g. obesogenic diet). The current study in female rhesus monkeys maintained in a standard laboratory chow (n = 18) or on obesogenic diet (n = 16) for 12-months tested the hypothesis that an obesogenic diet would alter central DA and homovanillic acid (HVA) concentrations, and be associated with increased CRP concentrations and decreased FC between corticostriatal regions at 12-months following dietary intervention. We specifically assessed FC between the nucleus accumbens (NAcc) and two sub-regions of the prefrontal cortex (PFC) previously associated with CRP concentrations, the ventromedial PFC (vmPFC) and the orbitofrontal cortex (OFC), which are also involved in emotional and motivational salience assessment, and in goal-directed behavior, impulse control and the salience/value of food, respectively. Results showed that CSF DA concentrations were decreased (p = 0.002), HVA:DA ratios were increased (p = 0.016), and body mass index was increased (p = 0.047) over the 12-months of consuming an obesogenic diet. At 12-months, females maintained in the obesogenic diet exhibited higher CRP concentrations than females consuming chow-only (p = 0.008). Linear regression analyses revealed significant CRP by dietary condition interactions on DA concentrations (β = -5.10; p = 0.017) and HVA:DA ratios (β = 5.14; p = 0.029). Higher CRP concentrations were associated with lower CSF DA concentrations (r = -0.69; p = 0.004) and greater HVA:DA ratios only in females maintained in the obesogenic dietary condition (r = 0.58; p = 0.024). Resting-state magnetic resonance neuroimaging (rs-fMRI) in a subset of females from each diet condition (n = 8) at 12-months showed that higher CRP concentrations were associated decreased FC between the NAcc and subregions of the prefrontal cortex (PFC; p's 0.05). Decreased FC between the NAcc and PFC subregions were also associated with lower concentrations of DA and greater HVA:DA ratios (p's 0.05). Overall, these data suggest that increased inflammatory signaling driving heightened CRP levels may mediate the adverse consequences of obesogenic diets on DA neurochemistry and corticostriatal connectivity.

Published
2020

23. Diet matters: Glucocorticoid-related neuroadaptations associated with calorie intake in female rhesus monkeys

Author

Eric Feczko, Damien A. Fair, Oscar Miranda-Dominguez, Zsofia Kovacs-Balint, Mar M. Sanchez, Melanie Pincus, Eric Earl, Jodi R. Godfrey, Vasiliki Michopoulos, Maylen Perez Diaz, and Mark E. Wilson

Subjects
0301 basic medicine, medicine.medical_specialty, Hydrocortisone, Endocrinology, Diabetes and Metabolism, Prefrontal Cortex, Hierarchy, Social, Nucleus accumbens, Social Environment, Affect (psychology), Nucleus Accumbens, Article, Feeding and Eating Disorders, Eating, Food Preferences, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, Reward, Dopamine receptor D2, Internal medicine, medicine, Animals, Chronic stress, Obesity, Social Behavior, Prefrontal cortex, Glucocorticoids, Biological Psychiatry, Resting state fMRI, Receptors, Dopamine D2, Endocrine and Autonomic Systems, business.industry, Feeding Behavior, medicine.disease, Macaca mulatta, Diet, Psychiatry and Mental health, 030104 developmental biology, Positron-Emission Tomography, Female, Energy Intake, business, Stress, Psychological, 030217 neurology & neurosurgery, Glucocorticoid, medicine.drug
Abstract

Exposure to psychosocial stressors increases consumption of palatable, calorically dense diets (CDD) and the risk for obesity, especially in females. While consumption of an obesogenic diet and chronic stress have both been shown to decrease dopamine 2 receptor (D2R) binding and alter functional connectivity (FC) within the prefrontal cortex (PFC) and the nucleus accumbens (NAcc), it remains uncertain how social experience and dietary environment interact to affect reward pathways critical for the regulation of motivated behavior. Using positron emission tomography (PET) and resting state functional connectivity magnetic resonance neuroimaging (rs-fMRI), in female rhesus monkeys maintained in a low calorie chow (n = 18) or a dietary choice condition (chow and a CDD; n = 16) for 12 months, the current study tested the overarching hypothesis that the adverse social experience resulting from subordinate social status would interact with consumption of an obesogenic diet to increase caloric intake that would be predicted by greater cortisol, lower prefrontal D2R binding potential (D2R-BP) and lower PFC-NAcc FC. Results showed that the consequences of adverse social experience imposed by chronic social subordination vary significantly depending on the dietary environment and are associated with alterations in prefrontal D2R-BP and FC in NAcc-PFC sub-regions that predict differences in caloric intake, body weight gain, and fat accumulation. Higher levels of cortisol in the chow-only condition were associated with mild inappetence, as well as increased orbitofrontal (OFC) D2R-BP and greater FC between the NAcc and the dorsolateral PFC (dlPFC) and ventromedial PFC (vmPFC). However, increased cortisol release in females in the dietary choice condition was associated with reduced prefrontal D2R-BP, and opposite FC between the NAcc and the vmPFC and dlPFC observed in the chow-only females. Importantly, the degree of these glucocorticoid-related neuroadaptations predicted significantly more total calorie intake as well as more consumption of the CDD for females having a dietary choice, but had no relation to calorie intake in the chow-only condition. Overall, the current findings suggest that dietary environment modifies the consequences of adverse social experience on reward pathways and appetite regulation and, in an obesogenic dietary environment, may reflect impaired cognitive control of food intake.

Published
2018

24. Brain Development During Adolescence in Male Rhesus Macaques: The Role of Puberty

Author

Mar M. Sanchez, Jessica Raper, Rebecca Richardson, Jocelyne Bachevalier, Longchuan Li, Melanie Pincus, Eric Feczko, Eric Earl, Adway Gopakumar, Damien A. Fair, Elyse L. Morin, and Zsofia Kovacs Balint

Subjects
Brain development, business.industry, Medicine, Physiology, business, Biological Psychiatry
Published
2021

25. Early Developmental Trajectories of Functional Connectivity Along the Visual Pathways in Rhesus Monkeys

Author

Oscar Miranda-Dominguez, Eric A. Maltbie, Eric Earl, J. Steele, Eric Feczko, Mar M. Sanchez, Ling Li, Damien A. Fair, Jocelyne Bachevalier, Elyse L. Morin, Brittany R. Howell, Melanie Pincus, Martin Styner, and Zsofia Kovacs-Balint

Subjects
Dorsum, Male, genetic structures, Cognitive Neuroscience, Period (gene), Prefrontal Cortex, Biology, Visual system, Macaque, 050105 experimental psychology, 03 medical and health sciences, Cellular and Molecular Neuroscience, 0302 clinical medicine, Functional neuroimaging, biology.animal, Neural Pathways, Animals, 0501 psychology and cognitive sciences, Attention, Visual Pathways, Social Behavior, Visual Cortex, Neuronal Plasticity, Socioemotional selectivity theory, Early weaning, Functional connectivity, Functional Neuroimaging, 05 social sciences, Brain, Amygdala, Macaca mulatta, Magnetic Resonance Imaging, Temporal Lobe, Frontal Lobe, Animals, Newborn, Original Article, Neuroscience, 030217 neurology & neurosurgery
Abstract

Early social interactions shape the development of social behavior, although the critical periods or the underlying neurodevelopmental processes are not completely understood. Here, we studied the developmental changes in neural pathways underlying visual social engagement in the translational rhesus monkey model. Changes in functional connectivity (FC) along the ventral object and motion pathways and the dorsal attention/visuo-spatial pathways were studied longitudinally using resting-state functional MRI in infant rhesus monkeys, from birth through early weaning (3 months), given the socioemotional changes experienced during this period. Our results revealed that (1) maturation along the visual pathways proceeds in a caudo-rostral progression with primary visual areas (V1–V3) showing strong FC as early as 2 weeks of age, whereas higher-order visual and attentional areas (e.g., MT–AST, LIP–FEF) show weak FC; (2) functional changes were pathway-specific (e.g., robust FC increases detected in the most anterior aspect of the object pathway (TE–AMY), but FC remained weak in the other pathways (e.g., AST–AMY)); (3) FC matures similarly in both right and left hemispheres. Our findings suggest that visual pathways in infant macaques undergo selective remodeling during the first 3 months of life, likely regulated by early social interactions and supporting the transition to independence from the mother.

Published
2018

26. Enhancing Micropropagation of Adenophora liliifolia: Insights from PGRs, Natural Extracts, and pH Optimization

Author

Zsófia Kovács, Liz Kelly Portocarrero, Péter Honfi, Ildikó Kohut, Eman Abdelhakim Eisa, and Andrea Tilly-Mándy

Subjects
Adenophora liliifolia, micropropagation, plant growth regulators (PGR), MS medium, AgNO3, NAA (1-Naphthaleneacetic acid), Botany, QK1-989
Abstract

The endangered plant species Adenophora liliifolia faces threats to its survival in the wild, necessitating the development of effective micropropagation techniques for potential reintroduction efforts. This study demonstrates that Adenophora liliifolia effectively reproduces on MS synthetic medium with diverse plant growth regulators (PGR) and natural extracts, facilitating swift micropropagation for potential future reintroduction endeavors. It highlights the substantial impact of PGR composition and natural extracts on the growth and development of A. liliifolia. The ideal growth medium for A. liliifolia was determined to be ½ MS with specific treatments. Additionally, incorporating silver nitrate (AgNO3) at 5 mg L−1 into the medium led to enhanced root formation and shoot length, albeit excessive concentrations adversely affected root development. Varying concentrations of NAA significantly affected different plant growth parameters, with the 0.1 mg L−1 treatment yielding comparable plant height to the control. Moreover, 50 mL L−1 of coconut water bolstered root formation, while 200 mL L−1 increased shoot formation during in vitro propagation. However, elevated doses of coconut water (CW) impeded root development but stimulated shoot growth. Experiments measuring chlorophyll a + b and carotenoid content indicated higher concentrations in the control group than differing levels of applied coconut water. Optimizing pH levels from 6.8–7 to 7.8–8.0 notably enhanced plant height and root formation, with significant carotenoid accumulation observed at pH 6.8–7. Soil samples from A. liliifolia’s natural habitat exhibited a pH of 6.65. Ultimately, the refined in vitro propagation protocol effectively propagated A. liliifolia, representing a pioneering effort and setting the stage for future restoration initiatives and conservation endeavors.

Published
2024
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27. Morphological, Histological and Genetic Evaluation of Gamma Radiation-Induced Mutation and Its Potential Application in Rudbeckia hirta (L.)

Author

Szilvia Kisvarga, Katalin Horotán, Dóra Hamar-Farkas, Zsófia Kovács, Antal Szőke, Muneeb Ahmad Wani, and László Orlóci

Subjects
Rudbeckia, ornamental, gamma, mutation, breeding, histology, Agriculture
Abstract

Many cultivars of annual ornamental horticulture have great phenotypic qualities but are less tolerant to the effects of current climate change and urbanization. A good example of this in Hungarian ornamental breeding is the Rudbeckia hirta cultivar “Őszifény”. The objective of this study was to determine whether gamma mutation breeding (using 5 Gy, 10 Gy, 30 Gy doses) can be employed to enhance genetic variability and create mutants with novel trait values. Furthermore, it is important to ascertain whether the altered genetic traits are proportionate to the observed changes in phenotype. As an original and innovative aspect of the research, this will assist in establishing appropriate dose rates for the species. Changes induced by gamma radiation have been mapped using morphological, histological, and genetic methods. The radiation dose of 5 Gy resulted in plants with the most favorable characteristics, including significant increases in branching and flower number. Additionally, the phenomenon of hormesis was observed. Beyond these, the dose of 30 Gy also had a significant effect because it resulted in plants with many flowers and bushy habits, making them suitable for use as ornamental potted plants. The 10 Gy dose resulted in a heterogeneous stand but showed the greatest genetic variation. These results may contribute to future breeding work and may pave the way for further urban application of R. hirta in the light of urbanization.

Published
2024
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28. New constraints on the evolution of 87Sr/86Sr of seawater during the Upper Triassic

Author

Sylvain Richoz, Zsofia Kovacs, Dorothee Hippler, Andre Baldermann, Leopold Krystyn, and Isaline Demangel

Subjects
Global and Planetary Change, geography, geography.geographical_feature_category, Radiogenic nuclide, 010504 meteorology & atmospheric sciences, Evaporite, Climate change, 020206 networking & telecommunications, 02 engineering and technology, Biostratigraphy, Sedimentary basin, Oceanography, 01 natural sciences, Supercontinent, chemistry.chemical_compound, Paleontology, Tectonics, chemistry, 0202 electrical engineering, electronic engineering, information engineering, Carbonate, Geology, 0105 earth and related environmental sciences
Abstract

The Late Triassic time interval witnessed several important biological turnovers, extinctions and onset of new life forms. Therefore, it is crucial to better constrain the tectonic, climatic and oceanographic framework at this time. The radiogenic strontium isotopic composition (87Sr/86Sr) of seawater, recorded in marine carbonates is sensitive to variations in continental weathering and oceanic spreading rates. This makes it a powerful proxy for palaeo-environmental reconstructions and an excellent global stratigraphic correlation tool of marine sediment records. In this study, we present a new and extended 87Sr/86Sr dataset across the late Norian - Hettangian interval, established from carbonate successions in Austria and Turkey. The well-established biostratigraphy and high sampling resolution allow evaluating changes in the 87Sr/86Sr record with a better time constraint than in previous studies. An exceptionally sharp trend towards unradiogenic values has been observed in the latest Norian and in the early Rhaetian from 0.70800 to 0.70779. Considering Late Triassic climate change, updated tectonic models and actual dating of magmatic events, possible explanations for the observed trend in the 87Sr/86Sr record are: (i) enhanced dissolution of pre-Norian carbonates, (ii) dissolution of widespread Late Triassic evaporites and (iii) tectonic reorganization of sedimentary basins due to the break-up of the supercontinent Pangea. At the very end of the Choristoceras marshi Zone, in the late Rhaetian, the unradiogenic 87Sr/86Sr trend is reversed. This is likely related to environmental changes due to the continental emplacement of the Central Atlantic Magmatic Province.

Published
2020

29. Postnatal Zika virus infection is associated with persistent abnormalities in brain structure, function, and behavior in infant macaques

Author

Jakob Habib, Varian K. Bailey, Damien A. Fair, David I. Watkins, Maria C. Alvarado, Circe E. McDonald, Jens Wrammert, Joyce Cohen, Justin T. O’Neal, Mehul S. Suthar, Maud Mavigner, Eric Feczko, Eric Earl, Thomas H. Vanderford, Xiaodong Zhang, Jessica Raper, Sanjeev Gumber, David H. O’Connor, Diogo M. Magnani, Sherrie Jean, Guido Silvestri, Ann Chahroudi, Siddhartha Kumar Bhaumik, Mark W. Burke, Mar M. Sanchez, Victoria Avanzato, Zsofia Kovacs-Balint, Martin Styner, Cameron Mattingly, and R. Paul Johnson

Subjects
Male, 0301 basic medicine, Wallerian degeneration, Pathology, medicine.medical_specialty, Central nervous system, Article, Zika virus, 03 medical and health sciences, Lateral ventricles, 0302 clinical medicine, Pregnancy, medicine, Animals, Tropism, medicine.diagnostic_test, biology, Zika Virus Infection, business.industry, Brain, Magnetic resonance imaging, General Medicine, medicine.disease, biology.organism_classification, Macaca mulatta, Magnetic Resonance Imaging, Astrogliosis, 030104 developmental biology, medicine.anatomical_structure, Animals, Newborn, RNA, Viral, Female, Functional magnetic resonance imaging, business, 030217 neurology & neurosurgery
Abstract

The Zika virus (ZIKV) epidemic is associated with fetal brain lesions and other serious birth defects classified as congenital ZIKV syndrome. Postnatal ZIKV infection in infants and children has been reported; however, data on brain anatomy, function, and behavioral outcomes following infection are absent. We show that postnatal ZIKV infection of infant rhesus macaques (RMs) results in persistent structural and functional alterations of the central nervous system compared to age-matched controls. We demonstrate ZIKV lymphoid tropism and neurotropism in infant RMs and histopathologic abnormalities in the peripheral and central nervous systems including inflammatory infiltrates, astrogliosis, and Wallerian degeneration. Structural and resting-state functional magnetic resonance imaging (MRI/rs-fMRI) show persistent enlargement of lateral ventricles, maturational changes in specific brain regions, and altered functional connectivity (FC) between brain areas involved in emotional behavior and arousal functions, including weakened amygdala-hippocampal connectivity in two of two ZIKV-infected infant RMs several months after clearance of ZIKV RNA from peripheral blood. ZIKV infection also results in distinct alterations in the species-typical emotional reactivity to acute stress, which were predicted by the weak amygdala-hippocampal FC. We demonstrate that postnatal ZIKV infection of infants in this model affects neurodevelopment, suggesting that long-term clinical monitoring of pediatric cases is warranted.

Published
2018

30. Living on the edge: morphological, karyological and genetic diversity studies of the Hungarian Plantago maxima populations and established ex situ collection

Author

Zsófia Kovács, Jelena Mlinarec, and Mária Höhn

Subjects
Chromosomes, Conservation, FISH, Giant plantain, ISSR, Morphometric traits, Botany, QK1-989
Abstract

Abstract Background The analysis of genetic diversity of protected plant species can greatly support conservation efforts. Plantago maxima Juss. ex Jacq. is a perennial species distributed along the Eurasian steppe. The westernmost range edge of the species’ distribution is located in the Pannonian basin, in Hungary where it is represented by a few, fragmented and highly endangered populations. We studied population diversity of all Hungarian range edge, natural populations, and one established ex situ population. One population from the centre of distribution (Kazakhstan) was implemented in the cpDNA haplotype study to compare the peripheral vs. central populations. We performed morphometric trait-based analysis, chromosome studies (morphometric analyses and FISH) and genetic diversity evaluations using inter simple sequence repeats (ISSR) and cpDNA trnL-trnF to evaluate differences between the in situ and ex situ populations as well as central vs. peripheral populations. Results Our results showed no obvious morphological differences among the in situ and ex situ populations in the period between 2018 and 2020. One ex situ subpopulation develops flowers three years in a row from 2019, which is a favourable indicator of the introduction success. Hungarian populations are exclusively diploids (2n = 2x = 12). The karyogram consists of 5 metacentric and 1 acrocentric chromosome pair. Plantago maxima has one 35S and two 5S rDNA loci, located on the acrocentric chromosome pair. Eight variable ISSR primers yielded 100 fragments, of which 74.6% were polymorphic (mean He = 0.220). A high level of genetic variation within population was observed (92%) while the genetic differentiation among the populations was only 8%. STRUCTURE analysis revealed that the largest Kunpeszér population separated from the rest of the Hungarian populations, indicating a high rate of admixture among the other ones. Based on the trnL-trnF sequence analysis the Hungarian populations represent a single haplotype, which can indicate a reduced diversity due to isolation and recent population decline. By contrast, Kazakh population represents a distinct haplotype compared to the Hungarian samples. Conclusions The present study draws the attention to the high conservation value of the Plantago maxima populations from the westernmost range edge of the species’ distribution.

Published
2023
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31. The spreading potential of electric powered vehicles in Hungary

Author

Zsofia Kovacs

Subjects
Engineering, business.industry, Distribution (economics), Operations management, Energy consumption, Total cost of ownership, Environmental economics, business
Abstract

Nowadays one of the most important social issues is to decrease the energy consumption and the environmental load of the transport sector. Although the efforts of the past decades resulted in considerable changes, the topic of the sustainable mobility comes into prominence in Hungary now. The aim of my paper is to examine the spread of the electric powered vehicles in Hungary. With the purpose of economical comparison, I make a TCO (Total Cost of Ownership) calculation in which I analyse the weight and the distribution of the total cost of ownership. With the help of my own model I demonstrate the spreading potential of the electric powered vehicles. I analyse the influencing factors of the possible spread, their effects and their expected consequences.

Published
2017

32. 5th International Symposium on Focused Ultrasound

Author

Menashe Zaaroor, Alon Sinai, Dorit Goldsher, Ayelet Eran, Maria Nassar, Ilana Schlesinger, Jonathon Parker, Vinod Ravikumar, Pejman Ghanouni, Sherman Stein, Casey Halpern, Vibhor Krishna, Amelia Hargrove, Punit Agrawal, Barbara Changizi, Eric Bourekas, Michael Knopp, Ali Rezai, Brian Mead, Namho Kim, Panagiotis Mastorakos, Jung Soo Suk, Wilson Miller, Alexander Klibanov, Justin Hanes, Richard Price, Shutao Wang, Oluyemi Olumolade, Tara Kugelman, Vernice Jackson-Lewis, Maria Eleni Karakatsani, Yang Han, Serge Przedborski, Elisa Konofagou, Kullervo Hynynen, Isabelle Aubert, Gerhard Leinenga, Rebecca Nisbet, Robert Hatch, Anneke Van der Jeugd, Harrison Evans, Jürgen Götz, Ann Van der Jeugd, Paul Fishman, Paul Yarowsky, Victor Frenkel, Shen Wei-Bin, Ben Nguyen, Carlos Sierra Sanchez, Camilo Acosta, Cherry Chen, Shih-Ying Wu, Muna Aryal, Iason T. Papademetriou, Yong-Zhi Zhang, Chanikarn Power, Nathan McDannold, Tyrone Porter, Zsofia Kovacs, Saejeong Kim, Neekita Jikaria, Farhan Qureshi, Michele Bresler, Joseph Frank, Henrik Odéen, George Chiou, John Snell, Nick Todd, Bruno Madore, Dennis Parker, Kim Butts Pauly, Mike Marx, Sumeeth Jonathan, William Grissom, Costas Arvanitis, Gregory Clement, Joshua de Bever, Allison Payne, Douglas Christensen, Guillaume Maimbourg, Mathieu David Santin, Alexandre Houdouin, Stéphane Lehericy, Mickael Tanter, Jean Francois Aubry, Christian Federau, Beat Werner, Dong-Guk Paeng, Zhiyuan Xu, Anders Quigg, Matt Eames, Changzhu Jin, Ashli Everstine, Jason Sheehan, M. Beatriz Lopes, Neal Kassell, James Drake, Karl Price, Lior Lustgarten, Vivian Sin, Charles Mougenot, Elizabeth Donner, Emily Tam, Mojgan Hodaie, Adam Waspe, Thomas Looi, Samuel Pichardo, Wonhye Lee, Yong An Chung, Yujin Jung, In-Uk Song, Seung-Schik Yoo, Hyun-Chul Kim, Jong-Hwan Lee, Charles Caskey, Wolf Zinke, Josh Cosman, Jillian Shuman, Jeffrey Schall, Christian Aurup, Hong Chen, Hermes Kamimura, Antonio Carneiro, Tao Sun, Navid Nazai, Sam Patz, Margaret Livingstone, Todd Mainprize, Yuexi Huang, Ryan Alkins, Martin Chapman, James Perry, Nir Lipsman, Allison Bethune, Arjun Sahgal, Maureen Trudeau, Hao-Li Liu, Po-Hung Hsu, Kuo-Chen Wei, Jonathan Sutton, Phillip Alexander, Eric Miller, Thiele Kobus, Alexandre Carpentier, Michael Canney, Alexandre Vignot, Kevin Beccaria, Delphine Leclercq, Cyril Lafon, Jean Yves Chapelon, Khe Hoang-Xuan, Jean-Yves Delattre, Ahmed Idbaih, David Moore, Alexis Xu, Paul Schmitt, Jessica Foley, Jonathan Sukovich, Charles Cain, Aditya Pandey, Neeraj Chaudhary, Sandra Camelo-Piragua, Steven Allen, Jon Cannata, Dejan Teofilovic, Jim Bertolina, Timothy Hall, Zhen Xu, Julien Grondin, Vincent Ferrera, Gail ter Haar, Petros Mouratidis, Elizabeth Repasky, Kelsie Timbie, Lena Badr, Benjamin Campbell, John McMichael, Andrew Buckner, Jessica Prince, Aaron Stevens, Timothy Bullock, Karin Skalina, Chandan Guha, Franco Orsi, Guido Bonomo, Paolo Della Vigna, Giovanni Mauri, Gianluca Varano, George Schade, Yak-Nam Wang, Venu Pillarisetty, Joo Ha Hwang, Vera Khokhlova, Michael Bailey, Tatiana Khokhlova, Ilya Sinilshchikov, Petr Yuldashev, Yulia Andriyakhina, Wayne Kreider, Adam Maxwell, Oleg Sapozhnikov, Ari Partanen, Jonathan Lundt, Tobias Preusser, Sabrina Haase, Mario Bezzi, Jürgen Jenne, Thomas Langø, Massimo Midiri, Michael Mueller, Giora Sat, Christine Tanner, Stephan Zangos, Matthias Guenther, Andreas Melzer, Arianna Menciassi, Selene Tognarelli, Andrea Cafarelli, Alessandro Diodato, Gastone Ciuti, Sven Rothluebbers, Julia Schwaab, Jan Strehlow, Senay Mihcin, Steffen Tretbar, Thomas Payen, Carmine Palermo, Steve Sastra, Kenneth Olive, Matthew Adams, Vasant Salgaonkar, Serena Scott, Graham Sommer, Chris Diederich, Joan Vidal-Jove, Eloi Perich, Antonio Ruiz, Manuela Velat, David Melodelima, Aurelien Dupre, Jeremy Vincenot, Chen Yao, David Perol, Michel Rivoire, Samantha Tucci, Lisa Mahakian, Brett Fite, Elizabeth Ingham, Sarah Tam, Chang-il Hwang, David Tuveson, Katherine Ferrara, Stephen Scionti, Lili Chen, Dusica Cvetkovic, Xiaoming Chen, Roohi Gupta, Bin Wang, Charlie Ma, Kenneth Bader, Kevin Haworth, Christy Holland, Narendra Sanghvi, Roy Carlson, Wohsing Chen, Christian Chaussy, Stefan Thueroff, Claudio Cesana, Carlo Bellorofonte, Qingguo Wang, Han Wang, Shengping Wang, Junhai Zhang, Alberto Bazzocchi, Alessandro Napoli, Robert Staruch, Chenchen Bing, Sumbul Shaikh, Joris Nofiele, Debra Szczepanski, Michelle Wodzak Staruch, Noelle Williams, Theodore Laetsch, Rajiv Chopra, Jarrett Rosenberg, Rachelle Bitton, Suzanne LeBlang, Joshua Meyer, Mark Hurwitz, Pavel Yarmolenko, Haydar Celik, Avinash Eranki, Viktoriya Beskin, Domiciano Santos, Janish Patel, Matthew Oetgen, AeRang Kim, Peter Kim, Karun Sharma, Alexander Chisholm, Dionne Aleman, Roberto Scipione, Michael Temple, Joao Guilherme Amaral, Ruby Endre, Maria Lamberti-Pasculli, Joost de Ruiter, Fiona Campbell, Jennifer Stimec, Samit Gupta, Manoj Singh, Sevan Hopyan, Gregory Czarnota, David Brenin, Carrie Rochman, Roussanka Kovatcheva, Jordan Vlahov, Katja Zaletel, Julian Stoinov, Matthew Bucknor, Viola Rieke, Jenny Shim, Korgun Koral, Brian Lang, Carlos Wong, Heather Lam, Alexander Shinkov, Jim Hu, Xi Zhang, Jonathan Macoskey, Kimberly Ives, Gabe Owens, Hitinder Gurm, Jiaqi Shi, Matthew Pizzuto, Christopher Dillon, Ivy Christofferson, Elaine Hilas, Jill Shea, Paul Greillier, Bénédicte Ankou, Francis Bessière, Ali Zorgani, Mathieu Pioche, Wojciech Kwiecinski, Julie Magat, Sandrine Melot-Dusseau, Romain Lacoste, Bruno Quesson, Mathieu Pernot, Stefan Catheline, Philippe Chevalier, Fabrice Marquet, Pierre Bour, Fanny Vaillant, Sana Amraoui, Rémi Dubois, Philippe Ritter, Michel Haïssaguerre, Mélèze Hocini, Olivier Bernus, Pamela Tebebi, Scott Burks, Blerta Milo, Michael Gertner, Jimin Zhang, Andrew Wong, Yu Liu, Azadeh Kheirolomoom, Jai Seo, Katherine Watson, Hua Zhang, Josquin Foiret, Alexander Borowsky, Doudou Xu, Maya Thanou, Miguell Centelles, Mike Wright, Maral Amrahli, Po-Wah So, Wladyslaw Gedroyc, Esther Kneepkens, Edwin Heijman, Jochen Keupp, Steffen Weiss, Klaas Nicolay, Holger Grüll, Matthew Nagle, Anastasia V. Nikolaeva, Marina E. Terzi, Sergey A. Tsysar, Bryan Cunitz, Pierre Mourad, Matthew Downs, Georgiana Yang, Qi Wang, Johnny Chen, Justin Farry, Adam Dixon, Zhongmin Du, Ali Dhanaliwala, John Hossack, Ashish Ranjan, Danny Maples, Rachel Wardlow, Jerry Malayer, Akhilesh Ramachandran, Hirofumi Namba, Motohiro Kawasaki, Masashi Izumi, Katsuhito Kiyasu, Ryuichi Takemasa, Masahiko Ikeuchi, Takahiro Ushida, Calum Crake, Satya V. V. N. Kothapalli, Wan Leighton, Zhaorui Wang, H. Michael Gach, William Straube, Michael Altman, Young-sun Kim, Hyo Keun Lim, Hyunchul Rhim, Johanna van Breugel, Manon Braat, Chrit Moonen, Maurice van den Bosch, Mario Ries, Cristina Marrocchio, Susan Dababou, Jae Young Lee, Hyun Hoon Chung, Soo Yeon Kang, Kook Jin Kang, Keon Ho Son, Dandan Zhang, Juan Plata, Peter Jones, Aurea Pascal-Tenorio, Donna Bouley, Aaron Bond, Robert Dallapiazza, Diane Huss, Amy Warren, Scott Sperling, Ryder Gwinn, Binit Shah, W. Jeff Elias, Colleen Curley, Ying Zhang, Karina Negron, Roger Abounader, Gesthimani Samiotaki, Tsang-Wei Tu, Georgios Papadakis, Dima Hammoud, Matthew Silvestrini, Frank Wolfram, Daniel Güllmar, Juergen Reichenbach, Denis Hofmann, Joachim Böttcher, Harald Schubert, Thomas G. Lesser, Scott Almquist, Francisco Camarena, Sergio Jiménez-Gambín, Noé Jiménez, Jin Woo Chang, Vandiver Chaplin, Rebekah Griesenauer, Michael Miga, Nicholas Ellens, Raag Airan, Alfredo Quinones-Hinojosa, Keyvan Farahani, Xue Feng, Samuel Fielden, Li Zhao, Max Wintermark, Craig Meyer, Sijia Guo, Xin Lu, Jiachen Zhuo, Su Xu, Rao Gullapalli, Dheeraj Gandhi, Omer Brokman, Hongchae Baek, Hyungmin Kim, Steven Leung, Taylor Webb, Natalia Vykhodtseva, Thai-Son Nguyen, Chang Kyu Park, Sang Man Park, Na Young Jung, Min Soo Kim, Won Seok Chang, Hyun Ho Jung, Michael Plaksin, Yoni Weissler, Shy Shoham, Eitan Kimmel, Pavel B. Rosnitskiy, Steve Krupa, Eilon Hazan, Omer Naor, Yoav Levy, Noam Maimon, Inbar Brosh, Itamar Kahn, Jessica Cahill, Elodie Constanciel Colas, Adrian Wydra, Roman Maev, Amirah Aly, Ozge Sesenoglu-Laird, Linas Padegimas, Mark Cooper, Barbara Waszczak, Seruz Tehrani, Craig Slingluff, James Larner, Kumari Andarawewa, Eugene Ozhinsky, Rutwik Shah, Roland Krug, Roel Deckers, Sabine Linn, Britt Suelmann, Arjen Witkamp, Paul Vaessen, Paul van Diest, Lambertus W. Bartels, Clemens Bos, Nicolas Borys, Gert Storm, Elsken Van der Wall, Navid Farr, Moez Alnazeer, Prateek Katti, Bradford Wood, Alexis Farrer, Cyril Ferrer, Baudouin Denis de Senneville, Marijn van Stralen, Jingfei Liu, J. Kent Leach, Stephan Zidowitz, Hsin-Lun Lee, Fang-Chi Hsu, Chia-Chun Kuo, Shiu-Chen Jeng, Tung-Ho Chen, Nai-Yi Yang, Jeng-Fong Chiou, Yi-tzu Kao, Chia-Hsin Pan, Jing-Fu Wu, Yi-Chieh Tsai, Sara Johnson, Dawei Li, Ye He, Ioannis Karakitsios, Michael Schwenke, Daniel Demedts, Xu Xiao, Ian Cavin, Emilee Minalga, Robb Merrill, Rock Hadley, Pascal Ramaekers, Martijn de Greef, Kian Shahriari, Mohammad Hossein Parvizi, Kiana Asadnia, Marzieh Chamanara, Seyed Kamran Kamrava, Hamid Reza Chabok, Ruben Stein, Sébastien Muller, Jeremy Tan, Cornel Zachiu, Hans-Peter Erasmus, Glen Van Arsdell, Lee Benson, Kee W. Jang, Mary Angstadt, Bobbi Lewis, Hailey McLean, Martijn Hoogenboom, Dylan Eikelenboom, Martijn den Brok, Pieter Wesseling, Arend Heerschap, Jurgen Fütterer, Gosse Adema, Kevin Wang, Pei Zhong, Joyce Joy, Helen McLeod, Harry Kim, Matthew Lewis, Arda Ozilgen, Peter Zahos, Dezba Coughlin, Xinyan Tang, Jeff Lotz, Kathleen Jedruszczuk, Amitabh Gulati, Stephen Solomon, Elena Kaye, John Mugler, Gaetano Barbato, Gian Luca Scoarughi, Cristiano Corso, Alessandro Gorgone, Ilaria Giuseppina Migliore, Zachary Larrabee, Arik Hananel, Jean-Francois Aubry, Ayele Negussie, Emmanuel Wilson, Reza Seifabadi, Hyungwon Moon, Jeeun Kang, Changbeom Sim, Jin Ho Chang, Hyuncheol Kim, Hak Jong Lee, Noboru Sasaki, Mitsuyoshi Takiguchi, Lukas Sebeke, Xi Luo, Bram de Jager, Maurice Heemels, Christopher Abraham, Laura Curiel, Rémi Berriet, Margit Janát-Amsbury, Joseph Corea, Patrick Peiyong Ye, Ana Clauda Arias, Micheal Lustig, and Bryant Svedin

Subjects
Pathology, medicine.medical_specialty, business.industry, Blood–brain barrier, Focused ultrasound, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, Disease therapy, 0302 clinical medicine, medicine.anatomical_structure, medicine, Radiology, Nuclear Medicine and imaging, business, 030217 neurology & neurosurgery
Published
2016

33. Particle-based nutrients and metal contaminants in the habitat of Unionidae mussels in the Tisza River (Hungary)

Author

Péter Dobosy, Wael Almeshal, Ádám Illés, Davaakhuu Tserendorj, Sirat Sandil, Zsófia Kovács, Anett Endrédi, and Gyula Záray

Subjects
riverine sediment, mussels, habitat, nutrients, metal contaminants, Environmental sciences, GE1-350
Abstract

Introduction:Unioniade is a species-rich family of freshwater mussels with an almost worldwide distribution. In Central European rivers Unio crassus, Unio tumidus and Unio pictorum have relatively high populations. In order to characterize the habitats of these suspension feeders, their nutrient supply and potential metal contaminants were investigated in near-bottom suspended (NBS) sediments and bottom sediments (BS) collected at four sampling locations along the Tisza River.Methods: The grain size distribution of sediments was determined by laser-diffraction technique. The total organic carbon (TOC) and the total Kjeldahl nitrogen (TN) were measured by a TOC analyzer and automated colorimetry, respectively. The phosphorous and metal concentrations were determined by inductively coupled plasma mass spectrometry following a microwave assisted acidic extraction of sediments with aqua regia.Results: The NBS sediments contained smaller grains than the BS samples, with roughly 85%–90% of the particles being less than 60 μm, allowing these mussels to catch them. Contrarily, only 2.47%–51.8% of BS samples were less than 60 μm. The NBS sediments contained 30, 23, and 15% more organic carbon, nitrogen, and phosphorous, respectively, than the BS samples. The rounded C:N:P molar ratios in the NBS sediments were 60:4:1, whereas they were 45:3:1 in the bottom sediments. The concentration of metals was also greater in the NBS sediments with the exception of Zn at Tokaj and Fe, Al, Mn, and Cr at Szeged, where prior contaminations transported by the tributaries Bodrog and Maros are stored in the top 10 cm of BS.Discussion: On basis of the measured C:N:P molar ratios it can be stated that soil-derived organic materials are the main sources of the nutrient elements in the habitats of suspension feeders in the Tisza River. The finer NBS sediments have higher specific surface area than the BS and thereby contain more biofilms on the grains resulting in higher proportion of organic nutrients and metal ions bounded as complexes or chelates. Comparing the measured metal concentrations of sediments with the concentration limits summarized in the Consensus-Based Sediment Quality Guidelines developed for evaluation of potential risk of metal contaminants in sediments for the benthic-dwelling organisms, it can be established that only the Hg concentration exceeded the probable effect concentration.

Published
2023
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34. Mid-Norian to Hettangian record and time-specific oolites during the end-Triassic Mass Extinction at Wadi Milaha, Musandam Peninsula, United Arab Emirates

Author

Ingrid Urban, Isaline Demangel, Leopold Krystyn, Mikael Calner, Zsófia Kovács, Gerit Gradwohl, Simon Lernpeiss, Florian Maurer, and Sylvain Richoz

Subjects
Norian-Rhaetian Boundary, Triassic-Jurassic Boundary, Arabian Platform, Chemostratigraphy, Ooids, Modal analysis, Geology, QE1-996.5
Abstract

The end-Triassic Mass Extinction (ETME) is generally regarded as a consequence of the environmental changes associated with the emplacement of the Central Atlantic Magmatic Province (CAMP) and ranks among the ‘big five’ mass extinctions in Earth history. A notable feature of the ETME is a halt in marine carbonate deposition followed by the formation of unusual facies such as carbonate cement fans and oolites in the early aftermath of the event. The ETME time interval has been well studied over the last few decades, in contrast to a few minor extinction events that preceded it, among them the extinctions associated with the Norian-Rhaetian boundary (NRB). This study provides new insights into these extinction events with complete mid-Norian to Hettangian δ18Ocarb and δ13Ccarb record from a key section at Wadi Milaha (Ras Al Khaimah Emirate, United Arab Emirates). Ooids are important proxies for palaeoenvironmental reconstruction. The post ETME oolite horizon is documented providing morphological classification as well as a detailed modal analysis of rock components and different types of coated grains. Through a multi-technique approach, we argue for the stability of the carbon cycle across the NRB extinction event and the existence of a hiatus at the TJB (Triassic-Jurassic Boundary) in Wadi Milaha. Our new morphological classification of post-extinction ooids is compatible with a major role for seawater geochemistry with respect to sedimentological processes, by example in the peculiar way ooids diversify and alternate with other kinds of coated grains.

Published
2023
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35. 'You Are a Cannibal'—A Case Report: Psychoanalysis of an Adolescent Boy with Bifrontal Lesions (Part 1: The First Year)

Author

Zsofia Kovacs, Günther Bernert, and Daphne Stock

Subjects
Psychotherapist, Psychoanalysis, medicine.diagnostic_test, General Neuroscience, Perspective (graphical), Metapsychology, Reality testing, Introjection, Neuropsychology and Physiological Psychology, Body schema, Id, ego and super-ego, medicine, Neuropsychological assessment, Psychoanalytic theory, Psychology
Abstract

Accompanying a male adolescent out of the darkness of being unable to differentiate between inside and outside, between being a boy or a girl—the psychoanalytic journey is described from both a clinical and a theoretical perspective. Based on Sigmund Freud’s metapsychology, psychoanalytic concepts such as regression, defense mechanisms of the ego such as projection and introjection, and features of the primary process are illuminated. Special emphasis is placed on changes in body schema and the role of language in reality testing. The therapeutic process cannot be understood without reference to the psychoanalytic concept of the ego and its early development. Using neuroimaging evidence, results of neuropsychological assessment, and excerpts of the ongoing therapy sessions, the pieces of the boy’s history are put together alongside the reconstruction-surgery of the frontal cranial bones.

Published
2011

36. Hemispheric Asymmetry and the Diversity of Emotional Experience in Anosognosia

Author

Mona Tondowski, Zsofia Kovacs, Oliver H. Turnbull, and Catherine Morin

Subjects
Conceptualization, General Neuroscience, media_common.quotation_subject, Anosognosia, Emotion classification, Neuropsychology, medicine.disease, Lateralization of brain function, Developmental psychology, Neuropsychology and Physiological Psychology, Denial, Hemispheric asymmetry, medicine, Psychology, Diversity (politics), media_common, Cognitive psychology
Abstract

A long-standing question in neuropsychology has been whether basic emotions are lateralized in one hemisphere in the brain. A more recent, controversial, conceptualization has been that both hemispheres process emotion, but the left is specialized for positive emotions and the right for negative emotions. This claim has been partially bolstered by the claim that denial of deficit (anosognosia) results from a loss of negative emotions after right-sided lesions. A range of objections have been raised to this account. These include the analytically inspired suggestion that anosognosia might result from an emotion-regulation deficit, associated with changes in body image, producing ill-maintained defenses against aspects of reality that are difficult to tolerate. The present study involved presenting emotion-related stimuli to each hemispace of anosognosic patients and measuring emotional experience. Across three different assessment methods, the anosognosic patients were able to experience the full range of ...

Published
2007

37. Multifunctional Modifying Systems Based on Ionic Liquids for Epoxy Resin Systems and Composites

Author

Dawid Zielinski, Andrea Szpecht, Ákos Pomázi, Zsófia Kovács, Beáta Szolnoki, Balázs Pinke, Andrea Toldy, and Marcin Smiglak

Subjects
ionic liquids, epoxy composites, flame-retardancy, curing agents, bioepoxy resin, Technology, Engineering (General). Civil engineering (General), TA1-2040, Biology (General), QH301-705.5, Physics, QC1-999, Chemistry, QD1-999
Abstract

The continuous development of the industry of composite materials and epoxy resins requires the development of components that modify these systems. It is extremely beneficial to modify functionality by using one or two substances instead of modifying only one system parameter. Typically, this end-use will determine the key parameters of the resin system that should be modified and the modification systems designed as such. In this study, we introduce novel systems utilizing ionic liquids, strategically designed to concurrently alter multiple system parameters, including: (i) flexibility, (ii) crosslinking density, and (iii) fire resistance. The following techniques were used in the research: (i) Differential Scanning Calorimetry (DSC), (ii) Thermogravimetric Analysis (TGA), (iii) Dynamic Mechanical Analysis (DMA) and (iv) fire performance tests (UL-94, Limiting Oxygen Index and Mass loss type cone calorimetry (MLC)) to show as much dependence of material parameters on the type of modifying additive as possible. Both the cured resin and the curing process as well as a single-layer composite reinforced with carbon fiber were tested. The results show that properly designed ionic liquids are able to perform many functions in the composite material and simultaneously affect several parameters, both by lowering and increasing them. In addition, they can exhibit activity in the field of flame-retardant composites.

Published
2023
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38. Microsatellite-Based Molecular Diversity in Sour Cherry Genotypes (Prunus cerasus L.) Cultivated in Hungary

Author

Janka Bedő, Andrea Kitti Tóth-Lencsés, Zsófia Kovács, Bánk Pápai, Antal Szőke, Erzsébet Kiss, and Anikó Veres

Subjects
genetic diversity, Prunus cerasus L., microsatellite, correlation, Plant culture, SB1-1110
Abstract

The aim of this study was to evaluate the genetic diversity of sour cherries using SSR markers, correlate the data with phenotypic traits, and investigate the suitability of Prunus-specific microsatellite markers in this species. Nineteen sour cherry genotypes from the Fruit Research Institute in Érd, Hungary, were analyzed using twelve SSR primer pairs. The number of alleles ranged from two to ten, with a mean value of 4.67 per locus. The highest number of alleles was generated with BPPCT 007. All the primers displayed a polymorphic pattern. The most informative markers, based on the highest PIC values, were CPPCT022, BPPCT041, and BPPCT030. The genotypes were grouped based on flowering time, ripening time, and fruit weight. To determine the correlation, we have performed a regression analysis association with fruit traits and molecular markers. The marker PceGA025 appeared to have an allele size that statistically significantly correlates to flowering and ripening time. Also, BPPCT002, BPPCT007 and UCDCH17 have an allele that significantly correlates to ripening time. Additionally, one of the alleles of UDP 98 410 appeared to be correlated with fruit weight.

Published
2023
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39. Prolonged survival upon ultrasound-enhanced doxorubicin delivery in two syngenic glioblastoma mouse models

Author

Beat Werner, Ernst Martin-Fiori, Zsofia Kovacs, Michele Bernasconi, Jörn Oliver Sass, Anahita Rassi, University of Zurich, and Bernasconi, Michele

Subjects
Pathology, medicine.medical_specialty, medicine.medical_treatment, 3003 Pharmaceutical Science, Brain tumor, Pharmaceutical Science, 610 Medicine & health, Blood–brain barrier, Mice, Sonication, Immune system, Drug Delivery Systems, Cell Line, Tumor, Parenchyma, Medicine, Animals, Doxorubicin, Chemotherapy, Antibiotics, Antineoplastic, Microbubbles, business.industry, Brain Neoplasms, Ultrasound, Brain, medicine.disease, medicine.anatomical_structure, 10036 Medical Clinic, Syngenic, Female, business, Glioblastoma, medicine.drug
Abstract

Glioblastoma multiforme (GBM) is the most common and most aggressive malignant primary brain tumor in humans with a very poor prognosis. Chemotherapeutical treatment of GBMs is limited by the blood-brain barrier (BBB). This physical and metabolic barrier separates the blood from the brain parenchyma and prevents the entry of toxins but also of potentially useful chemotherapeutics from the blood into the brain. Microbubble-enhanced focused ultrasound (MB-FUS) has been proposed to disrupt locally and reversibly the BBB to facilitate diffusion of drugs from the micro vasculature into brain tissue. The present study investigates the feasibility and the safety of such an approach in two syngenic mouse models of GBM (GL261 and SMA-560). Local doxorubicin (DOX) concentration in MB-FUS sonicated normal brain tissue as well as in brain tumor tissue was increased as compared to the unsonicated control tissue in the contralateral hemisphere. Moreover, ultrasound mediated BBB disruption, in combination with DOX therapy, resulted in a significant increase of survival and in a slower disease progression in the two syngenic GBM mouse models. In conclusion, our results confirm that MB-ultrasound might ultimately be an effective technology to improve the therapy of GBM, and they provide for the first time evidence that combining MB-FUS with DOX treatment is effective in syngenic mouse models for GBM which can serve as preclinical models to study the impact of immune system on the therapeutic application of MB-FUS chemotherapy.

Published
2014

40. The Calcium Isotope (δ44/40Ca) Record Through Environmental Changes: Insights From the Late Triassic

Author

Zsófia Kovács, Isaline Demangel, Andre Baldermann, Dorothee Hippler, Anne‐Désirée Schmitt, Sophie Gangloff, Leopold Krystyn, and Sylvain Richoz

Subjects
isotope proxy, Rhaetian, nannofossils, carbonates, end‐Triassic mas extinction, Triassic/Jurassic boundary, Geophysics. Cosmic physics, QC801-809, Geology, QE1-996.5
Abstract

Abstract Calcium isotopes (δ44/40Ca) are particularly useful in palaeo‐environmental studies due to the key role of carbonate minerals in continental weathering and their formation in seawater. The calcium isotope ratio can provide hints on past changes in the calcium fluxes, environmental shifts, ecological factors and alternatively diagenesis of carbonate rocks. The investigation of the Late Triassic calcium isotope record offers a great opportunity to evaluate such factors in a time interval that witnessed important environmental and ecological turnovers, such as the first appearance of calcareous nannoplankton, ocean acidification and periods of elevated extinction rates. In this study, we present a δ44/40Ca data set from the upper Norian (Upper Triassic) through the lower Hettangian (Lower Jurassic) interval. The isotope records reveal two globally significant signals: a ∼ 0.20‰ decrease through the early Rhaetian (Upper Triassic) and a small, negative (∼0.14‰) excursion corresponding to the emplacement of the Central Atlantic Magmatic Province, at the end of the Triassic. The possible explanations for these signals are changes in the isotopic ratio of the continental calcium influx to the ocean due to the high chemical weathering rate of carbonates and possibly ocean acidification, respectively. The considerable (∼0.15–0.30‰) offset in δ44/40Ca between study areas is likely the combined result of local differences in lithology and early marine diagenesis. The major evolutionary step represented by the first occurrence of calcareous nannoplankton did not have at this time a determining role on the calcium isotopic signature of the marine carbonates.

Published
2022
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41. P1‐230: Targeted drug delivery using focused ultrasound technology: Investigation of antibody delivery through the blood brain barrier

Author

Beat Werner, Ernst Martin-Fiori, Zsofia Kovacs, Lisa Strobel, and Roger M. Nitsch

Subjects
biology, Epidemiology, business.industry, Health Policy, Pharmacology, Blood–brain barrier, Focused ultrasound, Psychiatry and Mental health, Cellular and Molecular Neuroscience, medicine.anatomical_structure, Developmental Neuroscience, Targeted drug delivery, biology.protein, Medicine, Neurology (clinical), Geriatrics and Gerontology, Antibody, business
Published
2012

42. Transformation of perceptions as filter mechanisms in artificial intelligence

Author

Klaus Doblhammer, Dietmar Bruckner, Zsofia Kovacs, and Friedrich Gelbard

Subjects
Interpretation (logic), Transformation (function), Categorization, Software agent, Formalism (philosophy), Computer science, business.industry, ComputerApplications_COMPUTERSINOTHERSYSTEMS, Artificial intelligence, Tuple, Filter (higher-order function), Data structure, business
Abstract

When using the human mind as a template for artificial intelligence systems, principles of human thinking have to be modeled. One such very important principle is defense. Hence, in this article we describe a formalism to implement psychoanalytic defense mechanisms in artificial intelligence systems. They can be seen as transformations. A tuple 1 consisting of perceptions or drives (of a software agent in our case) combined with a value indicating their strength is transformed into a different tuple, if a potential interpretation is considered inappropriate by the defense. Some types of defense mechanisms can easily be transformed. Other more difficult ones and abstract types of defense mechanisms are transformed by the use of transformation tables. The transformations can alter, suppress or pass each of the components of a tuple or the whole tuple. In this article we show the transformation tables, we give a categorization of defense mechanisms, we show the general form of the transformations and we show some examples of transformations and ways to implement them in artificial intelligence.

Published
2011

43. Comparison of technical filter mechanisms and defense mechanisms of the human mind

Author

Klaus Doblhammer, Zsofia Kovacs, Friedrich Gelbard, Isabella Hinterleitner, Heimo Zeilinger, Christian Brandstätter, and Stefan Kohlhauser

Subjects
Cognitive science, Computer science, Perception, media_common.quotation_subject, Idealization, Isolation (psychology), Psychoanalytic theory, Thinking processes, Filter (software), media_common
Abstract

Looking for new paradigms in artificial intelligence, we are investigating functionalities of the human thinking process to manipulate information and filter perceptions. In this paper we introduce defense mechanisms of the human mind to be applied in artificial intelligence. We compare functionalities of defense mechanisms of the human mind with nowadays used filter mechanisms in artificial intelligence and explain reasons why defense mechanisms of the human mind open a broad new spectrum of possibilities and opportunities for artificial intelligence. In particular are these the defense mechanisms repression, deferral, sublimation, projection, disavowal, isolation, separation, depreciation and idealization. These defense mechanisms were chosen and devised with a team of psychoanalysts. We compare state-of-the-art artificial intelligence with psychoanalytic notions in our ongoing ARS project and explain why psychoanalysis is important for future developments in artificial intelligence. Finally, we give examples of similar projects.

Published
2011

44. P2‐503: Targeted drug delivery against beta‐amyloidosis in Alzheimer's disease mouse models by using focused ultrasound technology

Author

Lisa Strobel, Zsofia Kovacs, Beat Werner, and Roger M. Nitsch

Subjects
Oncology, medicine.medical_specialty, Epidemiology, business.industry, Health Policy, Amyloidosis, Disease, medicine.disease, Focused ultrasound, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Targeted drug delivery, Internal medicine, medicine, Neurology (clinical), Geriatrics and Gerontology, Beta (finance), business
Published
2011

45. Co-morbidity and quality of life in chronic kidney disease patients

Author

Istvan, Mucsi, Agnes Zsofia, Kovacs, Miklos Zsolt, Molnar, and Marta, Novak

Subjects
Treatment Outcome, Cost of Illness, Renal Dialysis, Research Design, Surveys and Questionnaires, Quality of Life, Humans, Kidney Failure, Chronic, Comorbidity
Abstract

Chronic kidney disease (CKD) is frequently associated with other chronic medical conditions. Adjusting for potential confounding factors that are associated with the outcome of interest is important both in clinical research and in everyday clinical practice. Comorbidity is such an important co-variable that it is reported to predict different outcomes in patients with ESRD. Health related quality of life (HRQoL) has increasingly been recognized as an important aspect of health care delivery, measure of effectiveness and patient experience, in chronic medical conditions. The progressively older ESRD patient population of industrialized countries is significantly debilitated by the burden of disease and also by the intrusiveness of renal replacement therapies. For these patients simply prolonging life is not enough. Little information has been published about the association of comorbidity and HRQoL. The aim of this review is to summarize the significance of comorbidity in patients with ESRD, with a special focus on the complex relationship between comorbidity and HRQoL. Several frequently used instruments will be described and the current literature, that compared the relative utility and accuracy of these tools, will be reviewed. Finally, the impact of selected medical conditions on HRQoL of patients with end-stage renal disease will be demonstrated.

Published
2008

46. Karen Kaplan-Solms / Mark Solms: Neuro-Psychoanalyse

Author

Zsofia Kovacs

Abstract

In seinem originellen Buch beschreibt das Ehepaar Solms ein Experiment der besonderen Art: Patienten der Neurologie mit lokalisierbaren Gehirnlasionen werden psychoanalytisch untersucht. Anhand exemplarischer, ausfuhrlicher Falldarstellungen begleiten uns Mark Solms, Neurowissenschaftler und Psychoanalytiker, und seine Frau Karen Kaplan-Solms, Sprachwissenschaftlerin und Psychoanalytikerin, in ein Grenzgebiet zwischen Leib und Seele, in eine „Tiefen-Neuropsychologie“. Sie fuhren uns vor Augen, was Neurologen immer schon beobachtet hatten, die Lehrbucher aber verschwiegen: Je nachdem, wo sich die abgrenzbare Gehirnlasion befindet, verandert sich die dynamische Personlichkeitsstruktur der Patienten. Mit der psychoanalytischen Methode, die auf der Annahme des Unbewussten basiert und mit der Technik der freien Assoziation, der ubertragung und Gegenubertragung, der Deutung und Interpretation usw. arbeitet, kann sich der Untersucher diesen Veranderungen am besten annahern und die „subjektive Sicht der Patienten“ der „objektiven Verletzung der Gehirnstruktur“ hinzufugen. Denn, so die Solm’sche Hypothese des „dual aspect monism“: „mind“ und „body“ sind aus demselben „Material“, blos aus zwei unterschiedlichen Perspektiven betrachtet.

Published
2008

47. Evaluation of Abnormal Hypocotyl Growth of Mutant Capsicum annuum Plants

Author

Bánk Pápai, Zsófia Kovács, Kitti Andrea Tóth-Lencsés, Janka Bedő, Gábor Csilléry, Anikó Veres, and Antal Szőke

Subjects
Capsicum annuum, gravitropism, phototropism, mutation, hypocotyl, Agriculture (General), S1-972
Abstract

Horticulture is a dynamically evolving and an ever-changing sector which needs new ideas, plant materials, and cultivating methods to produce more. Involving different mutants in breeding lines may lead to new opportunities to create new cultivating methods. pcx (procumbent plant) and tti (tortuosa internodi) Capsicum annuum mutant plants, which present abnormal stem growth, were investigated in various in vitro experiments. The pcx breeding line presents highly diverse hypocotyl growth even in the early phenophase, such as normally growing plants and the ‘laying’ habit. On the other hand, tti plants only present their elongated slender stem trait in a more mature phase. In our experiment of reorientation, we used one-sided illumination, where each of the phenotypes sensed and reacted to light, and only the pcx plants exhibited a negative gravitropic response. It was also the result that the tti plants sensed gravity, but the weak structure of the hypocotyls made them incapable of following its direction. Since the pcx plants were the only ones with an ‘antigravitropic’ growth, we used them to evaluate the time course they needed to adapt and follow the gravity vector after reorientation. The pcx plants sensing gravity adapted similarly to controls and started bending after 120 min, but those which presented as ‘anti-gravitropic’ did not respond even after 420 min.

Published
2023
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48. Corrigendum to ‘Prolonged survival upon ultrasound-enhanced doxorubicin delivery in two syngenic glioblastoma mouse models’ [Journal of Controlled Release, Volume 187 (10 August 2014), Pages 74–82]

Author

Zsofia Kovacs, Michele Bernasconi, Beat Werner, Ernst Martin-Fiori, Jörn Oliver Sass, and Anahita Rassi

Subjects
medicine.medical_specialty, business.industry, General surgery, Immunology, otorhinolaryngologic diseases, Pharmaceutical Science, Medicine, business, medicine.disease, Glioblastoma
Abstract

a Center for MR-Research, University Children's Hospital Zurich, Zurich, Switzerland b Oncology Department, University Children's Hospital Zurich, Zurich, Switzerland c Experimental Infectious Diseases and Cancer Research, University Children's Hospital Zurich, Zurich, Switzerland d Clinical Chemistry and Biochemistry, University Children's Hospital Zurich, Zurich, Switzerland e Children's Research Center, University Children's Hospital Zurich, Zurich, Switzerland

Published
2014

49. Tumors in murine brains studied by grating-based phase contrast microtomography

Author

Felix Beckmann, Bert Müller, Zsofia Kovacs, Georg Schulz, Rüdiger Schmitz, Marco Dominietto, Simone E. Hieber, and Peter Thalmann

Subjects
010302 applied physics, Pathology, medicine.medical_specialty, Transport oxygen, Angiogenesis, Chemistry, business.industry, Phase contrast microscopy, Healthy tissue, 02 engineering and technology, 021001 nanoscience & nanotechnology, medicine.disease, 01 natural sciences, Vascular architecture, 3. Good health, law.invention, Optics, Murine brain, law, Glioma, 0103 physical sciences, medicine, Tumor growth, 0210 nano-technology, business
Abstract

Angiogenesis, i.e. the formation of vessels, is one of the key processes during tumor development. The newly formed vessels transport oxygen and nutrients from the healthy tissue to the tumor and gives tumor cells the possibility to replicate. The principle of anti-angiogenic therapy is to block angiogenic process in order to stop tumor growth. The aim of the present study is the investigation of murine glioma vascular architecture at early (7 days), intermediate (10 and 15 days) and late (23 days) stage of growth by means of grating-based phase contrast microtomography. We demonstrate that this technique yields premium contrast between healthy and cancerous parts of murine brain tissues.

Published
2014
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50. Ex situ conservation in botanical gardens – challenges and scientific potential preserving plant biodiversity

Author

Zsófia KOVÁCS, Anna Mária CSERGŐ, Péter CSONTOS, and Mária HÖHN

Subjects
biodiversity conservation, ex situ, functional traits, genetic diversity, living collections, review, Forestry, SD1-669.5, Agriculture (General), S1-972
Abstract

In the Anthropocene, the world’s plant diversity is threatened with extinction and the erosion of the genetic diversity of natural populations. According to the State of the World’s Plants and Fungi 2020 of the Royal Botanic Gardens, Kew, two out of five of the ~350,000 known vascular plant species are at risk of extinction. Despite the considerable toolkit of biodiversity conservation practices, usually it is hard to choose the best option to stop biodiversity loss. Ex situ conservation has seen massive development due to radical losses of natural ecosystems, and its incrementing necessity has been underscored by Target 8 of the 2011-2020 Global Strategy for Plant Conservation. As we crossed the finish line of this strategy in 2020, a review of the accumulated knowledge on the ex situ living collections has become particularly important. Despite the increasing attention received by ex situ conservation, studies on the sustainability, quality, and usability of the plant material prior to establishing the garden collections are few, leaving major gaps unfilled in terms of best ex situ conservation practices. Here we present an overview of the results and experiences in ex situ conservation focusing on living plant collections, with the aim of guiding conservation practitioners towards the most efficient working methods. We evaluate the future needs and perspectives of this conservation technique, based on case studies on both woody and herb species. Possible conservation applications and priorities suggested for future works are summarized.

Published
2021
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