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9 results on '"Zou, Zhuoning"'

6. Stepwise de novo establishment of inactive X chromosome architecture in early development

Author

Du, Zhenhai, Hu, Liangjun, Zou, Zhuoning, Liu, Meishuo, Li, Zihan, Lu, Xukun, Harris, Clair, Xiang, Yunlong, Chen, Fengling, Yu, Guang, Xu, Kai, Kong, Feng, Xu, Qianhua, Huang, Bo, Liu, Ling, Fan, Qiang, Wang, Haifeng, Kalantry, Sundeep, and Xie, Wei

Abstract

X chromosome inactivation triggers a dramatic reprogramming of transcription and chromosome architecture. However, how the chromatin organization of inactive X chromosome is established de novo in vivo remains elusive. Here, we identified an Xist-separated megadomain structure (X-megadomains) on the inactive X chromosome in mouse extraembryonic lineages and extraembryonic endoderm (XEN) cell lines, and transiently in the embryonic lineages, before Dxz4-delineated megadomain formation at later stages in a strain-specific manner. X-megadomain boundary coincides with strong enhancer activities and cohesin binding in an Xistregulatory region required for proper Xistactivation in early embryos. Xistregulatory region disruption or cohesin degradation impaired X-megadomains in extraembryonic endoderm cells and caused ectopic activation of regulatory elements and genes near Xist, indicating that cohesin loading at regulatory elements promotes X-megadomains and confines local gene activities. These data reveal stepwise X chromosome folding and transcriptional regulation to achieve both essential gene activation and global silencing during the early stages of X chromosome inactivation.

Published
2024
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8. Translatome and transcriptome co-profiling reveals a role of TPRXs in human zygotic genome activation

Author

Zou, Zhuoning, primary, Zhang, Chuanxin, additional, Wang, Qiuyan, additional, Hou, Zhenzhen, additional, Xiong, Zhuqing, additional, Kong, Feng, additional, Wang, Qiujun, additional, Song, Jinzhu, additional, Liu, Boyang, additional, Liu, Bofeng, additional, Wang, Lijuan, additional, Lai, Fangnong, additional, Fan, Qiang, additional, Tao, Wenrong, additional, Zhao, Shuai, additional, Ma, Xiaonan, additional, Li, Miao, additional, Wu, Keliang, additional, Zhao, Han, additional, Chen, Zi-Jiang, additional, and Xie, Wei, additional

Published
2022
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9. A genetically engineered Escherichia coli that senses and degrades tetracycline antibiotic residue

Author

Mu, Zepeng, primary, Zou, Zhuoning, additional, Yang, Ye, additional, Wang, Wenbo, additional, Xu, Yue, additional, Huang, Jianyi, additional, Cai, Ruiling, additional, Liu, Ye, additional, Mo, Yajin, additional, Wang, Boyi, additional, Dang, Yiqun, additional, Li, Yongming, additional, Liu, Yushan, additional, Jiang, Yueren, additional, Tan, Qingyang, additional, Liu, Xiaohong, additional, Hu, Cheng, additional, Li, Hua, additional, Wei, Sha, additional, Lou, Chunbo, additional, Yu, Yang, additional, and Wang, Jiangyun, additional

Published
2018
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