Search

Objective To analyze the distribution bio-relationship of loci related antihypertensive drug efficacy in patients with essential hypertension (EH) in Guiyang region to support the development of clinical guidance for individualized medication of hypertension patients in this region. Methods A total of 406 EH patients who visited the Cardiology Department of Guiyang Hospital from December 2020 to December 2021 were collected as the study subjects and ligase sequencing method was applied to detect 7 gene loci of antihypertensive drugs. The distribution of gene loci in EH patients of different genders and from different geographic regions was evaluated. Results The mutation frequencies of the seven genes, CYP2D6*10(c.100 C＞T),CYP2C9*3(c.1075 A＞C),ADRB1(c.1165 G＞C),AGTR1(c.1166 A＞C),ACE(I/D),NPPA(T2238C) and CYP3A5*3(A6986G) were 47.29%, 5.91%, 73.15%, 6.65%, 34.24%, 0.49%, and 69.70% respectively; There was no significant difference in distribution frequency of hypertension drug related gene polymorphisms among different genders. Conclusions The distribution frequency of alleles in 7 antihypertensive drug efficacy related loci is not related to gender of patients.EH patients in Guiyang region are more sensitive to β-blockers and calcium antagonists, but less sensitive to other types of antihypertensive drugs. Therefore, the dose administered should be adjusted appropriately when using β-blockers and calcium antagonists.

Bioinspired nacre-like composites have attracted increasing research interests recently. They are typical composites with brick-and-mortar structure and usually employ a combination of hard material and soft material to achieve a good balance between stiffness and toughness. Impact response analysis of such composites is difficult due to their complex structure and interface. In this work, an effective finite element method-smoothed particle hydrodynamics (FEM-SPH) coupling approach is developed for impact response analysis of composite plates with brick-and-mortar structure. In the approach, hard material taking up the bulk of the composite plate is modeled with the SPH method, and soft material forming thin layer structures in the composite plate is modeled with FEM. A coupling algorithm considering failure behavior is proposed to model bonding interfaces between FEM parts and SPH parts. A particle-to-particle SPH contact algorithm is employed to handle contacts between SPH parts, and a penalty-based FEM-SPH contact algorithm is implemented to treat contacts between FEM parts and SPH parts. The developed coupling approach is used to calculate stress wave propagation in two bonded plates of the same material and different materials and a composite plate with brick-and-mortar structure. The accuracy of the coupling approach is validated by comparing the calculated results with those of analytical method and FEM. The coupling approach is then used to simulate the effects of some factors on the impact damage of composite plates with brick-and-mortar structure. The coupling approach can conveniently model the complex structure and bonding interface of the composite plates and is capable of capturing interface failure and fragmentation of the major composition of the composite plates during impact events. It provides a promising alternative for the impact response analysis of brick-and-mortar composite structures. [ABSTRACT FROM AUTHOR]

For problems of override trip in short-circuit fault and fault line selection in single-phase earth fault of coal mine power system, a protection technology of coal mine power based on GOOSE network with information sharing was proposed. The technology realizes anti-override trip with blocking signal and line selection in single-phase earth protection with zero sequence full current vector information based on GOOSE network. On the basis of existing gigabit industrial Ethernet of coal mine and high-speed real-time communication mechanism of GOOSE, fault information can be shared between protection devices, which can realize anti-override trip effectively and improve accuracy of fault line selection in single-phase earth fault.

Objective To discuss the correlation between C-peptide level and autonomic neuropathy in diabetic foot in patients with type 2 diabetes mellitus (T2DM). Methods The levels of fasting blood glucose (FBG), 2 h postprandial blood glucose (2 h-PG) and fasting C-peptide (FC-P) were detected in 124 T2DM patients. The Neuropad was used to test functions of sudomotor nerves in foot. Patients were divided into two groups: diabetic autonomic neuropathy (DAN) group and non-autonomic neuropathy group (NDAN) according to the results of functions of sudomotor nerves in foot. Values of gender, age, body mass index (BMI), blood pressure, FBG, 2 h-PG and FC-P were compared between the two groups. The Pearson correlation analysis was carried out between the indexes mentioned above and the time for completing color change of Neuropad. Results There were no significant differences in gender, age, FBG and 2 h-PG between two groups (P > 0.05). The FC-P level was (1.07±0.75)nmol/L in DAN group, which was significantly lower than that in NDAN group (1.43±1.00) nmol/L (P > 0.05). The time for completing color change of Neuropad was negatively correlated with C-peptide. Conclusion The autonomic nerve functions in diabetic foot is closely related with C-peptide. It is inferred that C-peptide may have protective effect on autonomic nerves in diabetic foot. [ABSTRACT FROM AUTHOR]

In patients with diabetes, glucose fluctuations, insulin resistance, poor circulation, and likely immune damage can easily lead to infections. Splenic abscess is rare in diabetic patients and is associated with a high mortality rate. Type 2 diabetes causes increased risks of splenic abscess, and timely and effective treatment can lower the mortality rate. We report here a case of type 2 diabetes complicated by multiple splenic abscesses.