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8. Palladium‐Catalyzed Ring‐Closing Aminoalkylative Amination of Unactivated Aminoenynes.

Author

Zou, Suchen, Yu, Bangkui, and Huang, Hanmin

Subjects
*AMINATION, *SECONDARY amines, *PALLADIUM catalysts, *PALLADIUM compounds, *ALDEHYDES, *PALLADIUM
Abstract

An efficient strategy for preventing the β‐hydride elimination of alkylpalladium species by ligation of the palladium with adjacent amino‐group was developed, which enabled a novel palladium‐catalyzed ring‐closing aminoalkylative amination of unactivated aminoenynes. The reaction is amenable to aminals, as well as aliphatic aldehydes with secondary amines, which provides straightforward access to structurally diverse exocyclic allenic amines bearing 5 to 12‐membered N‐heterocycles. With chiral phosphoramidite‐ligated palladium complex as the catalyst, an enantioselective variant was achieved with up to 93 % ee. Simultaneously, synthetic transformations of the chiral products were also conducted to afford structurally unique spirodiamines including one pharmaceutically active molecule via axial‐to‐central chirality transfer. [ABSTRACT FROM AUTHOR]

Published
2023
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