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Prema raspoloţivim dijagnostičkim metodama nije moguće preoperativno razlikovati benigne od malignih folikulskih tumora štitaste ţlezde, a najčešće ni intraoperativno zbog veoma slične ćelijske morfologije folikulskih adenoma i folikulskih karcinoma i nemogućnosti citološkog dokaza invazije kapsule ili krvnih sudova karakteristične za folikulske karcinome. U ovoj studiji, traţili smo moguće prediktivne faktore biološkog ponašanja odnosno maligniteta kod pacijenata s folikulskim karcinomom štitaste ţlezde koji bi omogućili ispravnu selekciju pacijenata za hirurško lečenje, a potom i izvoĎenje adekvatnog tipa operacije kod bolesnika s folikulskom tireoidnom neoplazmom. Metod: Ovom retrospektivnom studijom su bili obuhvaćeni svi pacijenti operisani zbog postojanja folikulskog tumora štitaste ţlezde u Centru za endokrinu hirurgiju Kliničkog Centra Srbije u Beogradu tokom petogodišnjeg perioda (2008-2012). U istraţivanje su uključena 263 operisana pacijenta. Na osnovu definitivnog histopatološkog nalaza ispitanici su podeljeni u dve grupe; folikulske adenome (97) i folikulske karcinome (166). Najvaţnije demografske i kliničke karakteristike analizirane su univarijantnom i multivarijantnom logističkom regresionom analizom. Potom je formiran nomogram tj. dvodimenzionalni dijagram koji omogućava pribliţno grafičko izračunavanje verovatnoće postojanja maligniteta kod pacijenata s dijagnozom folikulske lezije štitaste ţlezde odnosno primenu rezultata ovog rada u praksi. Rezultati: U grupi pacijenata operisanih zbog folikulskog adenoma (19 osoba muškog i 78 ţenskog pola) starosna dob je iznosila 19-79 godina s prosečnom starošću od 50 godina. U grupi pacijenata operisanih zbog folikulskog karcinoma (35 muških, 131 ţenska osoba) starosna dob je bila 15-78 godina, a prosečna starost 48 godina. Univarijantnom analizom pokazano je da se koncentracija tireoglobulina≥500 ng/ml, promer tumora<30 mm, prisustvo više od jednog tireoidnog čvora i nalaz afunkcijskog/hipofunkcijskog čvora, Establishing a preoperative diagnosis of thyroid follicular tumors is difficult due to the fact that the cell morphology of adenomas and carcinomas are similar and that capsular and vascular invasion cannot be determined by cytology. We analyzed predictive factors of biological behavior i.e. follicular carcinoma in order to enable a surgeon to indicate operative treatment and to perform an adequate operation for each patient with a follicular neoplasm. Method: In this retrospective study, we analyzed medical records of all patients with follicular thyroid tumors operated at Center for Endocrine Surgery, Clinical Center of Serbia, Belgrade between 2008 and 2012. A total of 263 operated patients were included and divided into follicular adenomas (97) and follicular carcinomas (166) based on the histopathology results. The most important demographic and clinical characteristics were analyzed by univariate and multivariate logistic regression analysis. Than, based on our results we formed a nomogram, a two-dimensional diagram designed to enable estimation of preoperative probability of malignancy in patients with diagnosis of the thyroid follicular lesion. Results: In adenoma group (19 males, 78 females) age range was 19-79, mean age 50. In carcinoma group (35 males, 131 females) age range was 15-78, mean age 48. Univariate analysis showed that thyroglobulin concentration≥500 ng/ml, tumor diameter<30 mm, presence of more than one thyroid nodule and an afunctional/hypofunctional nodule were significantly more frequent in follicular carcinoma than in follicular adenoma. Independent predictive factors of malignancy were elevated preoperative thyroglobulin concentration≥500 ng/ml and presence of more than one nodule. Based on our results we formed a nomogram, a two-dimensional diagram designed to enable estimation of preoperative probability of malignancy in patients with diagnosis of the thyroid follicular lesion by fine needle aspiration biopsy. Conclusion: Elevated preop