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Abstract Cancer remains a global health challenge, demanding early detection and accurate diagnosis for improved patient outcomes. An intelligent paradigm is introduced that elevates label‐free nonlinear optical imaging with contrastive patch‐wise learning, yielding stain‐free nonlinear optical computational histology (NOCH). NOCH enables swift, precise diagnostic analysis of fresh tissues, reducing patient anxiety and healthcare costs. Nonlinear modalities are evaluated, including stimulated Raman scattering and multiphoton imaging, for their ability to enhance tumor microenvironment sensitivity, pathological analysis, and cancer examination. Quantitative analysis confirmed that NOCH images accurately reproduce nuclear morphometric features across different cancer stages. Key diagnostic features, such as nuclear morphology, size, and nuclear‐cytoplasmic contrast, are well preserved. NOCH models also demonstrate promising generalization when applied to other pathological tissues. The study unites label‐free nonlinear optical imaging with histopathology using contrastive learning to establish stain‐free computational histology. NOCH provides a rapid, non‐invasive, and precise approach to surgical pathology, holding immense potential for revolutionizing cancer diagnosis and surgical interventions.

Colon cancer is one of the most common cancers, with 30–50 % of patients returning or metastasizing within 5 years of treatment. Increasingly, researchers have highlighted the influence of microbes on cancer malignant activity, while no studies have explored the relationship between colon cancer and the microbes in tumors. Here, we used tissue and blood samples from 67 colon cancer patients to identify pathogenic microorganisms associated with the diagnosis and prediction of colon cancer and evaluate the predictive performance of each pathogenic marker and its combination based on the next-generation sequencing data by using random forest algorithms. The results showed that we constructed a database of 13,187 pathogenic microorganisms associated with human disease and identified 2 pathogenic microorganisms (Synthetic.construct_32630 and Dicrocoelium.dendriticum_57078) associated with colon cancer diagnosis, and the constructed diagnostic prediction model performed well for tumor tissue samples and blood samples. In summary, for the first time, we provide new molecular markers for the diagnosis of colon cancer based on the expression of pathogenic microorganisms in order to provide a reference for improving the effective screening rate of colon cancer in clinical practice and ameliorating the personalized treatment of colon cancer patients.

In an increasingly competitive market environment, as an important decision for strategic change, CEO succession is a key step to driving sustainable development. The formulation of succession plans and how to improve the effectiveness of internal promotion mechanisms have been researched topics in executive team management. To explore the relationship between corporate executive succession planning and corporate performance, using 3955 CEO succession samples from 2599 companies during 2001-2015 in China, the Probit model, and the two-stage least squares method, the relationship between corporate CEO succession planning and corporate performance under the director-cum-CEO succession model was analysed. The results reveal that the formulation or not of succession plans in firms, particularly in listed firms, directly affects firm performance. Director-CEO internal succession decisions reduce firm performance relative to other CEO succession models. Conclusions obtained from this study indicate the relationship between succession planning and organisational performance at the micro level and provide a theoretical reference to further promote research related to succession decisions in listed companies and the longterm development interests of firms.

Copyright of Transformations in Business & Economics is the property of Vilnius University and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Background: During reports of emergency events, journalists experience psychological crisis and negative emotions aroused by the events. The psychological endurance of journalists, which is induced by high risks of the career, has attracted widespread attention. Emotional state and coping style are important factors that influence the psychological endurance of individuals. This study aimed to analyze the relationship of psychological endurance with anxiety and coping style among journalists engaged in emergency events. Methods: A total of 296 journalists in Hubei Province of China who participated in reports on emergency events from August to December 2017 were selected. Journalists were assessed using the Psychological Endurance Scale, Self-rating Anxiety Scale, and Simple Coping Style Questionnaire. Results: The total score of the psychological endurance of journalists engaged in emergency events is slightly lower than that of the Chinese norm. Score of anxiety of highly educated journalists is significantly higher than that of lowly educated journalists. Psychological endurance of journalists is negatively correlated with negative coping style and anxiety, but it is positively correlated with positive coping style. Positive coping style of journalists engaged in emergency events partially mediates the effects of psychological endurance on anxiety. Conclusion: Among journalists engaged in emergency events, the highly educated group presents obvious anxiety and negative coping style. Psychological endurance indirectly affects through positive coping style and directly affects anxiety of journalists.

Copyright of Transformations in Business & Economics is the property of Vilnius University and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Transformations in Business & Economics is the property of Vilnius University and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Transformations in Business & Economics is the property of Vilnius University and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Environmental pollution continues to aggravate with the acceleration of industrialization. As a result, the treatment of environmental pollution and protection of ecological environment have become issues of great concern during the social and economic development of China. Fund guarantee is an important link of environmental protection, and reasonable investment and financing strategies are the prerequisites of fund guarantee. To analyse the characteristics and status of environmental protection investment and financing in China and put forward targeted investment and financing strategies, the environmental protection investment and financing methods abroad were summarized. Then, the characteristics and types of current environmental protection investment and financing activities in China were examined. Results show that current environmental protection investment and financing activities in China are characterized by multiple fund sources, dominance of governance investment, and separation between investment and earnings. Specialized foundations for environmental protection, environmental policy funds, environmental pollution treatment project charges, and financial institutional loans are four major types of environmental protection investment and financing in China. There are four major problems, including inadequate total investment amount for environmental protection, unreasonable investment and financing structure, lack of investment and financing mechanism innovation, and lack of diversity of the investment and financing channels. This study's findings can provide references for decision making in terms of industrial structural transformation and upgrade, development enhancement of the environmental protection industry, and research into environmental protection investment and financing in China. [ABSTRACT FROM AUTHOR]

Public security expenditure is a financial means for maintaining social stability and can significantly inhibit growth in crime rate. However, the role of education investment in this relationship and the existence of regional heterogeneity have been neglected in existing studies. To explore the effects of public security expenditure and education investment on social stability, the provincial panel data of 31 provinces in China from 2007-2015 were examined, and the fixed-effect model was employed to analyze the relationship between public security expenditure, education investment, and social stability. Results show that public security expenditure and education investment have a significant negative effect on crime rate, and social stability can be enhanced by increasing public security expenditure and education investment. The social stabilizing effects of public security expenditure and education investment are more significant in areas with high sex ratio and low urbanization level. Additionally, crime can be more effectively curbed and social stability more effectively maintained by complementing public security expenditure with education investment. This study reveals the impact of regional heterogeneity on the social stabilizing effects of public security expenditure and education investment, as well as the coupling mechanism between them. The conclusions obtained in the study provide a theoretical basis and reference for formulating fiscal policies for public security. [ABSTRACT FROM AUTHOR]