50 results on '"Zohreh Ghoreishi"'
Search Results
2. The effects of propolis on pro-oxidant–antioxidant balance, glycemic control, and quality of life in chronic kidney disease: a randomized, double-blind, placebo-controlled trial
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Paniz Anvarifard, Alireza Ostadrahimi, Mohammadreza Ardalan, Maryam Anbari, and Zohreh Ghoreishi
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Medicine ,Science - Abstract
Abstract Chronic kidney disease (CKD) is a progressive kidney damage with an increasing prevalence. Some evidence suggests that propolis as a novel antioxidant, anti-inflammatory, and immunomodulatory agent may have beneficial effects in CKD. The aim of this study was to evaluate the efficacy of propolis on some kidney function parameters, pro-oxidant–antioxidant balance (PAB), glycemic status, quality of life, and blood pressure (BP) in patients with CKD. In this study, 44 patients with CKD were randomly assigned to receive propolis capsules at a dose of 250 mg daily or placebo for three months. Of 44 randomized individuals, 35 completed the trial. At the end of the intervention (end of month three), improvement in some dimensions of health-related quality of life (HRQoL) (derived from Kidney Disease and Quality of Life Short-Form (KDQOL- $${\mathrm{SF}}^{\mathrm{TM}}$$ SF TM , v. 1.3) questionnaire) were significantly higher in the propolis group than the placebo group, even after adjustment for baseline values, present of diabetes, and age (P 0.05). No serious adverse events were reported throughout the study. Propolis supplementation may improve the HRQoL of CKD patients. More studies are needed to validate the adjunct use of propolis for metabolic control of CKD patients.
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- 2023
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3. The effect of zingiber officinale on prooxidant-antioxidant balance and glycemic control in diabetic patients with ESRD undergoing hemodialysis: a double-blind randomized control trial
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Helya Rostamkhani, Parisa Veisi, Bahram Niknafs, Mohammad Asghari Jafarabadi, and Zohreh Ghoreishi
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Ginger ,End-stage Renal Disease ,Prooxidant-Antioxidant Balance ,Insulin resistance ,Diabetes ,Blood glucose ,Other systems of medicine ,RZ201-999 - Abstract
Abstract Background Diabetes management in hemodialysis patients with end-stage renal disease needs precision to avoid complications. The study aimed to investigate the effect of ginger supplementation on prooxidant-antioxidant balance, glycemic management, and renal function in diabetic hemodialysis patients. Trial design and methods Forty-four patients were randomly allocated to either the ginger or the placebo group in this randomized, double blind, placebo-controlled study. Patients in the ginger group received 2000 mg/d ginger for eight weeks, whereas those in the placebo group received equivalent placebos. After a 12- to 14-h fast, serum levels of fasting blood glucose (FBG), insulin, urea, creatinine, and prooxidant-antioxidant balance (PAB) were measured at baseline and at the end of the study. The homeostatic model evaluation of insulin resistance was used to determine insulin resistance (HOMA-IR). Results Serum levels of FBG (p = 0.001), HOMA-IR (p = 0.001), and urea (p = 0.017) were considerably lower in the ginger group compared to baseline, and the difference was significant when compared to the placebo group (p 0.05). On the other hand, insulin levels did not vary significantly across and among the groups (p > 0.05). Conclusion In summary, this study indicated that in diabetic hemodialysis patients, ginger could result to lower blood glucose levels, enhanced insulin sensitivity, and lower serum urea levels. Further studies with a more extended intervention period and various doses and forms of ginger are needed. Trial registration IRCT20191109045382N2. (06/07/2020), Retrospectively registered, https://www.irct.ir/trial/48467
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- 2023
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4. Remarkable impacts of probiotics supplementation in enhancing of the antioxidant status: results of an umbrella meta-analysis
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Vali Musazadeh, Amir Hossein Faghfouri, Meysam Zarezadeh, Azin Pakmehr, Pooria Taghavi Moghaddam, Fateme Hamedi-Kalajahi, Arian Jahandideh, and Zohreh Ghoreishi
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systematic review ,probiotics ,umbrella meta-analysis ,malondialdehyde (MDA) ,oxidative stress biomarkers ,Nutrition. Foods and food supply ,TX341-641 - Abstract
IntroductionNumerous meta-analyses have demonstrated the beneficial effects of probiotics on oxidative stress biomarkers, although some studies have contradictory results. Therefore, the current research was conducted to obtain a precise and definite understanding on the impact of probiotics on oxidative stress biomarkers in adults.MethodsWe conducted a comprehensive systematic search of results on Scopus, PubMed, Embase, Web of Science, and Google Scholar dating up to March 2022. Fifteen meta-analyses were included in this umbrella meta-analysis. The random-effects model was employed to obtain the overall effect size. Subgroup analyses were carried out based on supplementation dosage and duration, mean age, and study population.ResultsOur results indicated that probiotics supplementation meaningfully decreased serum malondialdehyde (MDA) (ESWMD = −0.56, 95% CI: −0.72, −0.39; p < 0.001, and ESSMD = −0.50, 95% CI: −0.66, −0.34; p < 0.001). Moreover, the findings showed that probiotics resulted in a significant increase in total antioxidant capacity (TAC) (ESWMD = 29.18, 95% CI: 16.31, 42.04; p < 0.001, and ESSMD = 0.25, 95% CI: 0.02, 0.47; p = 0.032), total glutathione (GSH) (ESWMD: 30.65; 95% CI: 16.94, 44.35, p < 0.001), and nitric oxide (NO) (ESWMD: 1.48; 95% CI: 0.31, 2.65, p = 0.013; I2 = 51.7%, p = 0.043).DiscussionProbiotics could be considered a strong agent in the reinforcement of antioxidant status and preventing the incidence of chronic diseases.
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- 2023
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5. Effects of Iranian propolis on renal function, prooxidant-antioxidant balance, metabolic status, and quality of life in patients with chronic kidney disease: A study protocol of an ongoing randomized, double-blind, placebo-controlled clinical trial
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Paniz Anvarifard, Maryam Anbari, Alireza Ostadrahimi, Mohammadreza Ardalan, and Zohreh Ghoreishi
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Propolis ,Chronic kidney disease ,Protocol study ,Randomized controlled trial ,Medicine (General) ,R5-920 - Abstract
Background: Chronic kidney disease (CKD) is a prevalent and progressive disease that is impacted by hyperglycemia, hypertension (HTN), and oxidative stress (OS). Propolis, a natural resinous mixture produced by honeybees from plant materials, has been shown to possess antioxidant, anti-inflammatory, antihyperglycemic, and antihypertensive properties, along with hepato-renal protective effects. This study aims to evaluate the efficacy of propolis supplementation on patients with CKD. Methods: This multi-centered, randomized, double-blind, placebo-controlled clinical trial will evaluate the effectiveness of propolis supplementation in 44 eligible patients with CKD. Participants will be randomly allocated to receive either propolis capsule (500 mg, containing 125 mg Iranian alcoholic propolis extract) or placebo, twice daily for three months. The primary outcome is improvement in kidney function parameters of CKD patients, while secondary outcomes include changes in prooxidant-antioxidant balance (PAB), glycemic status, quality of life, and blood pressure (BP). The study will be conducted at Tabriz University of Medical Sciences in Tabriz, Iran. Discussion: If the results of this study reveal remarkable effectiveness of propolis in improving quality of life and clinical outcomes in patients with CKD, this compound may reach a new milestone as an adjunctive therapy for CKD and it opens a new window for further studies. Trial registration: Iranian Registry of Clinical Trials, IRCT20191218045798N1. Prospectively registered on 07 June 2020. Updated on 30 August 2021. https://en.irct.ir/trial/48603.
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- 2023
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6. Renoprotective effects of the ginger (Zingiber officinale) on Diabetic kidney disease, current knowledge and future direction: a systematic review of animal studies
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Parisa Veisi, Meysam Zarezade, Helya Rostamkhani, and Zohreh Ghoreishi
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Ginger ,Zingiber officinale ,Diabetes ,Hyperglycemia ,Renal ,Kidney ,Other systems of medicine ,RZ201-999 - Abstract
Abstract Objective Diabetic kidney disease affects approximately 40% of diabetic patients and is the leading cause of chronic kidney disease (CKD) worldwide. As a result, preventing renal complications in diabetic patients is critical. Ginger (Zingiber Officinale Rosco) is a popular spice and natral medicine. The present study was a systematic review focused on the existing evidence of the renoprotective effect of ginger extract on some features of diabetic kidney disease. Methods The literature was searched in online databases such as PubMed, Scopus, EMBASE, ProQuest databases, and Google Scholar from inception to July 2022. Results This review included 41 articles that met the eligibility criteria. Ginger supplementation was found to be associated with a significant decrease in blood glucose in 28 studies. Nine studies showed a significant reduction in malondialdehyde (MDA) after supplementation. Also, seventeen studies showed decreased serum levels of creatinine. Fifteen studies reported a decrease in total cholesterol (TC) and fourteen studies showed a lowered triglycerides (TG) concentrations. In twenty-six studies, ginger reduced renal injuries due to diabetes. Conclusion Ginger may improve blood sugar indices, lipid profile, some inflammatory markers, oxidative stress, and pathologic injuries in diabetic kidney disease. However, future well-designed clinical trials and meta-analyses are required for a solid consensus.
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- 2022
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7. Inositol supplementation and body mass index: A systematic review and meta‐analysis of randomized clinical trials
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Meysam Zarezadeh, Azadeh Dehghani, Amir Hossein Faghfouri, Nima Radkhah, Mohammad Naemi Kermanshahi, Fatemeh Hamedi Kalajahi, Niyaz Mohammadzadeh Honarvar, Zohreh Ghoreishi, Alireza Ostadrahimi, and Mehrangiz Ebrahimi Mamaghani
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body mass index ,inositol ,meta‐analysis ,obesity ,systematic review ,Internal medicine ,RC31-1245 - Abstract
Abstract Background Inositol is a sugar‐alcohol and recognized as a key component of cell membrane phospholipids. It has crucial role in the cell signaling pathways and contribute to improving glycemic responses. Although some earlier studies have revealed the effect of inositol mediating glucose uptake by improving insulin sensitivity, the benefit of inositol supplementation in patients with overweight and obesity is not completely understood. This study aimed to assess the impact of inositol supplementation on body mass index (BMI) through a systematic review and meta‐analysis of controlled clinical trials. Methods A systematic search was performed to August 2021 in the following databases: PubMed‐Medline, Embase, Web of Science and Scopus. Fifteen controlled clinical trials investigating the effect of inositol on adult's BMI were finally included in the study. A random‐effects model was employed to estimate the effect size. Subgroup analysis was performed by dose, duration, age, type of inositol. Meta‐regression was used to investigate presence of any linear relationship. Begg's and Egger's tests were carried out to detect small study effect. Results The results of pooled analysis showed that inositol supplementation significantly decreased BMI scores (WMD = −0.41 kg/m2; 95% CI: −0.78, −0.04; p = 0.028). Subgroup analysis was performed to identify the source of heterogeneity among studies (I2 = 73.9%, p
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- 2022
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8. A comprehensive insight into the molecular and cellular mechanisms of the effects of Propolis on preserving renal function: a systematic review
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Paniz Anvarifard, Maryam Anbari, Alireza Ostadrahimi, Mohammadreza Ardalan, and Zohreh Ghoreishi
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Propolis ,Acute kidney injury ,AKI ,Chronic kidney disease ,CKD ,Renal function ,Nutrition. Foods and food supply ,TX341-641 ,Nutritional diseases. Deficiency diseases ,RC620-627 - Abstract
Abstract Background The present systematic review is conducted, focusing on the existing evidence of Propolis's effects due to its various health benefits, mainly antioxidant and anti-inflammatory properties on preserving renal function. Methods A systematic search of PubMed, Scopus, Embase, ProQuest, and Google Scholar was undertaken for relevant papers published from the start until January 2021. Results This review revealed that Propolis affects fasting blood sugar (FBS), postprandial blood glucose, advanced glycation end products (AGEs) concentrations, malondialdehyde (MDA) levels, urinary concentrations of reactive oxygen metabolites (Tbars), total oxidant status (TOS), oxidative stress index (OSI), and 8-hydroxy-2′-deoxyguanosine (8-OHdG) formation favorably. The findings on hemoglobin A1C (HbA1C), insulin, homeostasis model assessment of insulin resistance (HOMA-IR), β-cell function (HOMA-β), quantitative insulin sensitivity check index (QUICKI), and lipid profile were controversial. Moreover, a significant reduction in renal nuclear factor kappa B (NF-κB), serum immunoglobulins, renal ED-1+ cells, and urinary monocyte chemoattractant protein-1 (MCP-1) following Propolis supplementation has been reported, while the results on interleukin-6 (IL-6), tumor necrosis factor α (TNF-α), nitric oxide (NO), nitric oxide synthetase (NOS), and high sensitivity C-reactive protein (hs-CRP) were controversial. Furthermore, included studies showed its anti- proteinuria and kidney restoring effects. Conclusion In this review, both human and animal studies provide us evidences that Propolis could potentially improve the glycemic status, oxidative stress, renal tissue damage, and renal function. Further studies are needed to determine the underlying mechanisms.
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- 2022
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9. Association between alcohol consumption and pancreatic cancer: a systematic review of cohort studies
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Zohreh Ghoreishi, Ali Esfahani, Shima Asgarzad, Laleh Payahoo, and Fatemeh Hajizadeh-Sharafabad
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alcohol ,alcoholic drink ,pancreatic cancer ,systematic review. ,Medicine (General) ,R5-920 - Abstract
Background: Among all types of cancers, pancreatic cancer has poor prognosis with 5-year survival below 10%. In theory, alcohol intake may be a modifiable risk factor for pancreatic cancer due to its role in multiple carcinogenic and metabolic signaling pathways. In addition, alcohol consumption may lead to chronic pancreatitis which is underlying cause of pancreatic cancer. However, little is known about whether this factor is associated with pancreatic cancer. This study aimed to systematically review the cohort studies investigating the possible link between alcohol consumption and the morbidity or mortality of pancreatic cancer. Methods: This study was carried out based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). All of cohort studies that assessed the association between alcohol intake and the risk of pancreatic cancer or death were included in this systematic review without a language restriction. Electronic databases including PubMed, Web of science, Scopus, and Google scholar were searched using the keywords "pancreatic cancer" and "alcohol" and similar words from 1990 to April 2021 to find the cohort studies. Results: 858 articles were identified, of which 806 were excluded and the full-text of 52 papers were evaluated for the eligibility. Eventually, 22 articles were eligible and were included in this study. Many of the articles assessed the impacts of low to moderate alcohol intake. A comprehensive review of these studies showed that low to moderate alcohol consumption had a non-significant correlation with pancreatic cancer, while high alcohol consumption was significantly associated with the risk of pancreatic cancer or death. The results also revealed that high liquor consumption was associated with higher risk of pancreatic cancer. Nevertheless, the follow-up durations in most of these studies were shorter than that to lead to pancreatic cancer. Conclusion: Long-term heavy alcohol drinking can increase the morbidity or mortality of pancreatic cancer. Regarding that several genetic and environmental variations involve in the pathogenesis of this cancer, simultaneous control of these differences should be addressed to determine the net effect of alcohol drinking on pancreatic cancer.
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- 2021
10. Effects of Hydroalcoholic Extracts of Cloves (Syzygium aromaticum) on the Serum Biomarkers, Antioxidant Status, and Histopathological Changes of Kidneys in Diabetic Rats
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Seyd-Hosein Abtahi-Eivari, Majid Shokoohi, Mohammad Ghorbani, Monireh Halimi, Hossein Hajizadeh, Tala Pourlak, Javad Bahrami, and Zohreh Ghoreishi
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cloves ,diabetes ,lipid profile ,antioxidant status ,kidney damages ,Medicine - Abstract
Objectives: The purpose of this study was to assess the possible impact of hydroalcoholic extracts of cloves (Syzygium aromaticum) on glucose status, lipid profile, and histopathological changes in the kidneys of diabetic rats. Materials and Methods: Thirty-two rats (male) were distributed into 4 groups (n=8), including one group as healthy control and three diabetic groups. Streptozotocin was used for inducing diabetes (50 mg/kg). Diabetic rats were grouped into a control group (DC), diabetic treated with 4 mg/kg hydroalcoholic extract of S. aromaticum (DSA), and the DG group receiving 5 mg/kg glibenclamide. After the treatment period, the blood samples of the rats were frozen in -70°C for measuring glycemic indices, insulin, lipid profile, some oxidative stress markers, and enzymes with antioxidant properties. Finally, the kidney was removed for the histological study. Results: Control, DSA, and DG groups had significantly lower levels of fasting blood sugar compared to the DC group (P
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- 2021
11. Vitamin D supplementation positively affects anthropometric indices: Evidence obtained from an umbrella meta-analysis
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Vali Musazadeh, Meysam Zarezadeh, Faezeh Ghalichi, Fateme Hamedi Kalajahi, and Zohreh Ghoreishi
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vitamin D ,anthropometric indices ,obesity ,body mass index ,umbrella meta-analysis ,Nutrition. Foods and food supply ,TX341-641 - Abstract
Despite the growing evidence from meta-analyses on vitamin D’s anti-obesity properties, their results are controversial. The current umbrella review was performed to assess the available evidence and provide a conclusive explanation in this regard. The international databases PubMed, Scopus, Embase, Web of Science and Google Scholar were systematically searched till March, 2022. A random-effects model was used to run the meta-analysis. All meta-analyses that examined the effect of vitamin D supplementation on BW, BMI, WC, and fat mass were included. Findings of 14 meta-analyses revealed that vitamin D supplementation reduced body mass index (BMI) (ES: −0.11 kg/m2; 95% CI: −0.18, −0.05, p?0.001; I2 = 61.0%, p < 0.001), and waist circumference (WC) (ES = −0.79 cm; 95% CI: −1.20, −0.37; p < 0.001; I2 = 46.5%, p = 0.096) in comparison to control group. However, the effects of vitamin D on body weight (ES = −0.16 kg, 95% CI: −0.36, 0.04; p = 0.125; I2 = 57.0%, p = 0.017), and fat mass (ES: 0.02, 95% CI: −0.20, 0.24, p = 0.868; I2 = 0.0%, p = 0.531) were not considerable. Vitamin D supplementation significantly improved levels of obesity indices such as BMI, and WC.
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- 2022
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12. The protective antioxidant activity of ginger extracts (Zingiber Officinale) in acute kidney injury: A systematic review and meta-analysis of animal studies
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Helya Rostamkhani, Amir Hossein Faghfouri, Parisa Veisi, Alireza Rahmani, Nooshin Noshadi, and Zohreh Ghoreishi
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Antioxidan ,Zingiber officinale ,Oxidative stress ,Reactive oxygen species ,Acute kidney injury ,Nutrition. Foods and food supply ,TX341-641 - Abstract
Zingiber officinale (Ginger) is considered an herbal medicinal plant with antioxidant features. This study attempted to perform a meta-analysis of the data obtained from previously conducted animal studies on the protective antioxidant effect of ginger extracts on acute kidney injury. This literature search was conducted using some databases, including PubMed, Embase, and Scopus published up to August 2021, by searching relevant keywords. Thereafter, the pooled effect size was estimated using the random effect model. The SYRCLE’s risk of bias tool was then conducted to assess the quality of the obtained studies. The source of heterogeneity among these studies was detected using meta-regression and subgroup analyses. Finally, the meta-analysis on 17 eligible articles revealed that ginger extract supplementation significantly increased SOD (SMD = 5.451 U/mg protein; 95 % CI: 2.099, 8.804; P = 0.005), CAT (SMD = 2.912 U/mg protein; 95 % CI: 0.583, 5.241; P = 0.024), GSH (SMD = 3.400 µg/mg protein; 95 % CI: 1.941,4.859; P
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- 2022
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13. Evaluation of iron overload by cardiac and liver T2* in β-thalassemia: Correlation with serum ferritin, heart function and liver enzymes
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Hengameh Khadivi Heris, Babak Nejati, Khatereh Rezazadeh, Hossein Sate, Roya Dolatkhah, Zohreh Ghoreishi, and Ali Esfahani
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cardiomyopathy ,t2* magnetic resonance imaging ,ferritin ,iron overload ,β-thalassemia ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Introduction: In this study, we aimed to assess the relationship of cardiac and hepatic T2* magnetic resonance imaging (MRI) values as a gold standard for detecting iron overload with serum ferritin level, heart function, and liver enzymes as alternative diagnostic methods. Methods: A total 58 patients with beta-thalassemia major who were all transfusion dependent were evaluated for the study. T2* MRI of heart and liver, echocardiography, serum ferritin level, and liver enzymes measurement were performed. The relationship between T2* MRI findings and other assessments were examined. Cardiac and hepatic T2* findings were categorized as normal, mild, moderate, and severe iron overload. Results: 22% and 11% of the patients were suffering from severe iron overload in heart and liver, respectively. The echocardiographic findings were not significantly different among different iron load categories in heart or liver. ALT level was significantly higher in patient with severe iron overload than those with normal iron load in heart (P=0.005). Also, AST level was significantly lower in normal iron load group than mild, moderate, and severe iron load groups in liver (P
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- 2021
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14. Risk factors for paclitaxel-induced peripheral neuropathy in patients with breast cancer
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Zohreh Ghoreishi, Seyedali Keshavarz, Mohammad Asghari Jafarabadi, Zahra Fathifar, Karyn A Goodman, and Ali Esfahani
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Peripheral nervous system diseases ,Paclitaxel ,Breast neoplasms ,Receptors, progesterone ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract Background Paclitaxel induced peripheral neuropathy (PIPN) is a major debilitating side effect of paclitaxel in patients with breast cancer with no fully known mechanisms. The aim of the study was to find out the possible risk factors for PIPN. Methods Eligible patients with node positive breast cancer undergoing chemotherapy with paclitaxel were assessed. They belonged to an initial randomized controlled trial in which the effectiveness of omega-3 fatty acids in preventing and reducing severity of PIPN was evaluated (protocol ID: NCT01049295). Reduced total neuropathy score (r-TNS) was used for measuring PIPN. All analyses were performed adjusting for intervention effect. The association between age, BMI, BSA, pathological grade, molecular biomarkers and PIPN was evaluated. Results Fifty-seven patients with breast cancer were investigated. Age was significantly associated with risk of PIPN (RR:1.50, P value = .024). Body mass index and BSA had significant association with severity of PIPN (B:1.28, P = .025; and B: 3.88, P = .010 respectively). Also, BSA showed a significant association with the risk of PIPN (RR: 2.28, P = .035; B: 3.88, P = .035). Incidence and severity of PIPN were much more pronounced in progesterone receptor positive (PR+) patients (RR:1.88, P = .015 and B:1.54, P = .012). Multivariate analysis showed that age and the status of PR+ were independent risk factor for incidence and the status of PR+ was the only independent risk factor for severity of PIPN. Conclusion Age, BSA and the status of PR+, should be considered as the risk factors for PIPN before commencement of chemotherapy with paclitaxel in patients with breast cancer. Older patients, those with greater BSA and PR+ patients may need closer follow up and more medical attention due to greater incidence and severity of PIPN.
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- 2018
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15. Prealbumin/CRP Based Prognostic Score, a New Tool for Predicting Metastasis in Patients with Inoperable Gastric Cancer
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Ali Esfahani, Nima Makhdami, Elnaz Faramarzi, Mohammad Asghari Jafarabadi, Alireza Ostadrahimi, Mousa Ghayour Nahand, and Zohreh Ghoreishi
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Diseases of the digestive system. Gastroenterology ,RC799-869 - Abstract
Background. There is a considerable dissimilarity in the survival duration of the patients with gastric cancer. We aimed to assess the systemic inflammatory response (SIR) and nutritional status of these patients before the commencement of chemotherapy to find the appropriate prognostic factors and define a new score for predicting metastasis. Methods. SIR was assessed using Glasgow Prognostic Score (GPS). Then a score was defined as prealbumin/CRP based prognostic score (PCPS) to be compared with GPS for predicting metastasis and nutritional status. Results. 71 patients with gastric cancer were recruited in the study. 87% of patients had malnutrition. There was a statistical difference between those with metastatic (n=43) and those with nonmetastatic (n=28) gastric cancer according to levels of prealbumin and CRP; however they were not different regarding patient generated subjective global assessment (PG-SGA) and GPS. The best cut-off value for prealbumin was determined at 0.20 mg/dL and PCPS could predict metastasis with 76.5% sensitivity, 63.6% specificity, and 71.4% accuracy. Metastatic and nonmetastatic gastric cancer patients were different in terms of PCPS (P=0.005). Conclusion. PCPS has been suggested for predicting metastasis in patients with gastric cancer. Future studies with larger sample size have been warranted.
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- 2016
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16. Influence of Chemotherapy on the Lipid Peroxidation and Antioxidant Status in Patients with Acute Myeloid Leukemia
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Zohreh Sanaat, Alireza Nikanfar, Zohreh Ghoreishi, Ali Esfahani, and Amir Ghorbanihaghjo
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Acute myeloid leukemia ,Chemotherapy ,Oxidative stress ,Antioxidant ,Medicine (General) ,R5-920 - Abstract
Chemotherapeutic agents used in patients with cancer cause to generate the enormous amounts of free radicals associated with cell injury. In this study we assess the effects of chemotherapy regimen on oxidant/antioxidant status in patients with acute myeloid leukemia (AML). 38 newly diagnosed patients with acute myeloid leukemia were recruited in this study. All patients received cytarabine and daunorubicin as chemotherapy regimen. Plasma levels of malondialdehyde (MDA), total antioxidant status (TAS), and the levels of erythrocyte activity of superoxide dismutase (SOD) and glutathione peroxidase (GPx) were determined before chemotherapy and 14 days after chemotherapy with cytarabine and daunorubicin. Plasma MDA concentrations increased significantly (from 2.68±0.89 nmol/L to 3.14±1.29 nmol/L) during the 14days post-chemotherapy period (P=0.04). Plasma TAS concentrations changed with chemotherapy from 1.09±0.15 mmol/L to 1.02±0.14 mmol/L with P=0.005. Erythrocyte SOD and GPX activity decreased overtime from 1157.24±543.61 U/g Hb to 984.01±419.09 U/g Hb (P=0.04) and 46.96±13.70 U/g Hb to 41.40±6.44 U/g Hb (P=0.02) respectively. We report here that there is an increase in malondialdehyde levels and a decrease in the levels of antioxidant enzymes and total antioxidant status. This suggests that chemotherapy causes these changes as a result of enormous production of reactive oxygen species in the patients with AML. Antioxidant supplementation must be approached with caution because of the probability of reduction the therapeutic efficacy of these cytotoxic drugs.
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- 2012
17. Influence of Chemotherapy on the Lipid Peroxidation and Antioxidant Status in Patients with Acute Myeloid Leukemia
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Ali Esfahani, Zohreh Ghoreishi, Alireza Nikanfar, Zohreh Sanaat, and Amir Ghorbanihaghjo
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Acute myeloid leukemia ,Chemotherapy ,Oxidative stress ,Antioxidant ,Medicine (General) ,R5-920 - Abstract
Chemotherapeutic agents used in patients with cancer cause to generate the enormous amounts of free radicals associated with cell injury. In this study we assess the effects of chemotherapy regimen on oxidant/antioxidant status in patients with acute myeloid leukemia (AML). 38 newly diagnosed patients with acute myeloid leukemia were recruited in this study. All patients received cytarabine and daunorubicin as chemotherapy regimen. Plasma levels of malondialdehyde (MDA), total antioxidant status (TAS), and the levels of erythrocyte activity of superoxide dismutase (SOD) and glutathione peroxidase (GPx) were determined before chemotherapy and 14 days after chemotherapy with cytarabine and daunorubicin. Plasma MDA concentrations increased significantly (from 2.68±0.89 nmol/L to 3.14±1.29 nmol/L) during the 14days post-chemotherapy period (P=0.04). Plasma TAS concentrations changed with chemotherapy from 1.09±0.15 mmol/L to 1.02±0.14 mmol/L with P=0.005. Erythrocyte SOD and GPX activity decreased overtime from 1157.24±543.61 U/g Hb to 984.01±419.09 U/g Hb (P=0.04) and 46.96±13.70 U/g Hb to 41.40±6.44 U/g Hb (P=0.02) respectively. We report here that there is an increase in malondialdehyde levels and a decrease in the levels of antioxidant enzymes and total antioxidant status. This suggests that chemotherapy causes these changes as a result of enormous production of reactive oxygen species in the patients with AML. Antioxidant supplementation must be approached with caution because of the probability of reduction the therapeutic efficacy of these cytotoxic drugs.
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- 2012
18. Delayed hemolytic transfusion reaction with multiple alloantibody (Anti S, N, K) and a monospecific autoanti-JK b in intermediate β-thalassemia patient in Tabriz
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Roya Dolatkhah, Ali Esfahani, Seyed Esmaeil Torabi, Iraj Asvadi Kermani, Zohreh Sanaat, Jamal Eivazei Ziaei, Alireza Nikanfar, Seyed Hadi Chavoshi, Zohreh Ghoreishi, and Atabak Asvadi Kermani
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Alloantibody ,autoanti-JK b ,delayed hemolytic transfusion reaction ,β-Thalassemia ,Diseases of the blood and blood-forming organs ,RC633-647.5 - Abstract
It appears that delayed hemolytic transfusion reactions may occur several days after the administration of donor red cells is true even though they have been shown to be compatible in cross match tests by the antiglobulin technique. A specific case was observed in our center, which confirms the fact. The patient was a 37-year-old male suffering from intermediate β-thalassemia. He had a history of two previous transfusions, with unknown transfusion reaction. In the last transfusion, laboratory data showed: Hb 7.8 g/dL and Hematocrit (Hct) 24.2%. The patient received two units of cross matched, compatible concentrated red blood cells (RBCs). After eight days a severe reaction was observed with clinical evidence of tachycardia, fatigue, fever, back pain, chest discomfort, jaundice, nausea and anorexia. Accordingly delayed hemolytic transfusion reaction was suspected, and anti-RBC antibodies were tested. Laboratory tests revealed the presence of three alloantibodies: Anti-N, anti-S, anti-K, and a monospecific autoanti-JK b .
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- 2013
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19. Responsible enzymes for metabolizing vitamin D in patients with acute leukemia and the relationship with treatment outcomes: a case-control study
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Sadegh Asoubar, Ali Esfahani, Amir Vahedi, Seyyede-Momeneh Mohammadi, Meysam Zarezadeh, Fatemeh Hamedi-Kalajahi, Zohreh Ghoreishi, and Neda Roshanravan
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25-Hydroxyvitamin D3 1-alpha-Hydroxylase ,Leukemia, Myeloid, Acute ,Cancer Research ,Oncology ,Case-Control Studies ,Humans ,Receptors, Calcitriol ,Hematology ,Vitamin D ,Vitamin D3 24-Hydroxylase - Abstract
Anti-cancer properties of vitamin D have been reported in studies. The aim of this study was to evaluate the expression of some key enzymes involved in vitamin D metabolism and the serum levels of related proteins. Fifty-four patients with acute myeloid leukemia (AML) and 55 eligible individuals were studied as the control group. The expression of VDR, CYP27B1, and CYP24A1 genes was measured. Serum levels of related proteins were quantified. The association between the studied variables and treatment outcomes: duration of fever and neutropenia, length of hospital stay, achievement of complete remission and overall survival has been investigated. Expression of CYP24A1 gene and serum levels of CYP27B1 and CYP24A1 proteins were significantly higher in the patient group. CYP24A1 gene expression, its blood concentrations and serum levels of CYP27B1 were significantly higher in the AML group. Vitamin D status and key enzymes did not show a strong change in AML patients neither did associate with treatment outcomes except CYP24A1.
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- 2022
20. Melatonin effectiveness in amelioration of oxidative stress and strengthening of antioxidant defense system: Findings from a systematic review and dose–response meta-analysis of controlled clinical trials
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Meysam Zarezadeh, Maliheh Barzegari, Baharak Aghapour, Shaghayegh Adeli, Fateme Khademi, Vali Musazadeh, Parsa Jamilian, Parmida Jamilian, Laleh Fakhr, Fatemeh Chehregosha, Zohreh Ghoreishi, and Alireza Ostadrahimi
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Oxidative Stress ,Nutrition and Dietetics ,Malondialdehyde ,Endocrinology, Diabetes and Metabolism ,Dietary Supplements ,Humans ,Antioxidants ,Melatonin - Abstract
Oxidative stress is involved in the development of chronic diseases. It has been suggested that melatonin has a protective role against oxidative stress by activation of antioxidant enzymes and scavenging free-radicals. Present study aimed to investigate the effect of melatonin supplementation on oxidative stress and antioxidant biomarkers such as malondialdehyde (MDA), increased total antioxidant capacity (TAC), superoxide dismutase (SOD), and Glutathione peroxidase (GPx).Systematic search was performed to identify relevant studies in PubMed/Medline, SCOPUS, Web of Science and Embase databases and Google Scholar up to September 2020. Meta-analysis was conducted using random-effect model. Subgroup analysis and meta-regression was used to identify sources of heterogeneity. The quality of studies was assessed using Cochrane Collaboration's tool. Publication bias was assessed by visual inspection of funnel plot.A total number of 16 eligible articles were included in the meta-analysis. The dosages of melatonin varied between 3 and 400 mg/day, with a duration range between 1.42 and 12 weeks. Melatonin supplementation significantly increased serum levels of TAC [SMD: 1.59; 95% CI: 0.89, 2.29; P 0.001; (IResults of the current meta-analysis showed that melatonin supplementation had a significant impact on attenuating of oxidative stress and enhancing antioxidant performance. Melatonin supplementation could be suggested as a safe complementary approach in amelioration of the chronic diseases.
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- 2022
21. Effect of Zingiber officinale on Lipid Profile and Some Inflammatory Markers in Diabetic Hemodialysis Patients: A Randomized Double-Blind Placebo-Controlled Clinical Trial
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Parisa Veisi, Helya Rostamkhani, Bahram Niknafs, Mohammad Asghari Jafarabadi, and Zohreh Ghoreishi
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Complementary and alternative medicine - Abstract
Background. Diabetes, inflammation, and abnormal lipid levels are the main risk factors for mortality in end-stage renal disease (ESRD). The present study aimed to investigate the effects of ginger supplementation on inflammatory markers and lipid profile in diabetic patients with ESRD undergoing hemodialysis. Methods. In this study, 44 patients were randomly assigned to either the ginger or the placebo group. The patients in the ginger group received 2000 mg/d ginger for eight weeks, while the control group received the placebo with the same protocol. The serum concentrations of triglyceride (TG), total cholesterol (TC), low-density lipoprotein-cholesterol (LDL-c), high-density lipoprotein-cholesterol (HDL-c), albumin, and high-sensitivity C-reactive protein (hs-CRP) were measured after a 12- to 14-hours fast at the baseline and the end of the study, as along with the platelet-to-lymphocyte ratio (PLR), neutrophil-to-lymphocyte ratio (NLR), and Glasgow prognostic score (GPS). Results. Forty-one subjects were analyzed based on the intention-to-treat method of all included patients. Serum levels of TG ( p = 0.003 ), hs-CRP ( p = 0.022 ), and NLR ( p = 0.001 ) decreased significantly in the ginger group compared to the placebo group, while albumin concentration in serum was elevated ( p = 0.022 ). However, there were no significant differences in GPS, levels of TC, LDL-C, HDL-C, and PLR within and between the groups ( p > 0.05 ). Conclusion. Ginger administration reduced NLR, hs-CRP, and TG serum levels and increased serum albumin levels in included patients. Thus, ginger can be considered an effective complementary treatment for these patients. This trail is registered with IRCT20191109045382N3.
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- 2023
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22. Spirulina supplementation and oxidative stress and pro‐inflammatory biomarkers: A systematic review and meta‐analysis of controlled clinical trials
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Helda Tutunchi, Meysam Zarezadeh, Alireza Ostadrahimi, Sara Mohiti, Mehrangiz Ebrahimi Mamaghani, Zohreh Ghoreishi, and Fatemeh Naeini
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0301 basic medicine ,medicine.medical_specialty ,Physiology ,Thiobarbituric acid ,Subgroup analysis ,medicine.disease_cause ,Gastroenterology ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Physiology (medical) ,Internal medicine ,Spirulina ,TBARS ,Medicine ,Inflammation ,Pharmacology ,business.industry ,Malondialdehyde ,Oxidative Stress ,030104 developmental biology ,chemistry ,Strictly standardized mean difference ,030220 oncology & carcinogenesis ,Meta-analysis ,business ,Body mass index ,Biomarkers ,Oxidative stress - Abstract
Studies investigating the effects of spirulina on inflammation and oxidative stress status are controversial. Therefore, the current systematic review and meta-analysis aimed to evaluate the impacts of spirulina supplementation on oxidative stress indicators and inflammatory markers. PubMed-Medline, SCOPUS, Web of Science, Embase databases and Google Scholar were searched up to 1 October 2020. Random-effect analysis was applied to perform meta-analysis. Subgroup analyses and multivariate meta-regression were performed to find heterogeneity sources. Quality assessment was conducted using Cochrane Collaboration's tool. A total of 11 studies that enrolled 465 subjects were included in our meta-analysis. Pooled results demonstrated a significant increase in interleukin-2 (IL-2) concentrations [Standardized mean difference (SMD = 2.69 pg/mL; 95% CI: 0.26, 5.11; P = .03)]; however this result changed to insignificant (SMD = 0.54 pg/mL; 95% CI: -1.29, 2.27; P > .05) when sensitivity analysis performed. A marginal decreasing effect were also found on interleukin-6 (IL-6) (SMD = -0.72 mg/dL; 95% CI: -1.50, 0.07; P = .073) and thiobarbituric acid reactive substances (TBARS) levels (SMD = -0.65; 95% CI: -1.37, 0.08; P = .08). In addition, results of subgroup analysis revealed a significant reduction in IL-6 and TBARS concentrations when the baseline body mass index (BMI) of participants was lower than 25 kg/m2 . Moreover, spirulina had no significant effect on tumour necrosis factor-α (TNF-α) (SMD = -0.07 mg/dL; 95% CI: -0.33, 0.18; P = .56) and malondialdehyde (MDA) concentrations (SMD = -0.42; 95% CI: -0.98, 0.14; P = .14). Spirulina consumption contributed to a significant increase in IL-2 concentrations changing to insignificant after sensitivity analysis and marginal decreasing effects on IL-6 and TBARS levels. No considerable impacts were observed on TNF-α and MDA concentrations.
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- 2021
23. Evaluation of iron overload by cardiac and liver T2* in β-thalassemia: Correlation with serum ferritin, heart function and liver enzymes
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Ali Esfahani, Khatereh Rezazadeh, Hossein Sate, Zohreh Ghoreishi, Roya Dolatkhah, Babak Nejati, and Hengameh Khadivi Heris
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medicine.medical_specialty ,Thalassemia ,Cardiomyopathy ,030204 cardiovascular system & hematology ,Gastroenterology ,030218 nuclear medicine & medical imaging ,Correlation ,03 medical and health sciences ,0302 clinical medicine ,Liver enzyme ,Internal medicine ,medicine ,Diseases of the circulatory (Cardiovascular) system ,iron overload ,Serum ferritin ,medicine.diagnostic_test ,biology ,business.industry ,ferritin ,Magnetic resonance imaging ,Gold standard (test) ,medicine.disease ,Ferritin ,RC666-701 ,β-thalassemia ,biology.protein ,t2* magnetic resonance imaging ,Original Article ,Cardiology and Cardiovascular Medicine ,business ,cardiomyopathy - Abstract
Introduction: In this study, we aimed to assess the relationship of cardiac and hepatic T2* magnetic resonance imaging (MRI) values as a gold standard for detecting iron overload with serum ferritin level, heart function, and liver enzymes as alternative diagnostic methods. Methods: A total 58 patients with beta-thalassemia major who were all transfusion dependent were evaluated for the study. T2* MRI of heart and liver, echocardiography, serum ferritin level, and liver enzymes measurement were performed. The relationship between T2* MRI findings and other assessments were examined. Cardiac and hepatic T2* findings were categorized as normal, mild, moderate, and severe iron overload. Results: 22% and 11% of the patients were suffering from severe iron overload in heart and liver, respectively. The echocardiographic findings were not significantly different among different iron load categories in heart or liver. ALT level was significantly higher in patient with severe iron overload than those with normal iron load in heart (P=0.005). Also, AST level was significantly lower in normal iron load group than mild, moderate, and severe iron load groups in liver (P
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- 2021
24. Lutein supplementation combined with a low-calorie diet in middle-aged obese individuals: effects on anthropometric indices, body composition and metabolic parameters
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Mehrnoosh Sarreshtedari, Fatemeh Hajizadeh-Sharafabad, Ali Tarighat-Esfanjani, and Zohreh Ghoreishi
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Blood Glucose ,0301 basic medicine ,Lutein ,Waist ,media_common.quotation_subject ,Calorie restriction ,Medicine (miscellaneous) ,Physiology ,Fatty Acids, Nonesterified ,030204 cardiovascular system & hematology ,Placebo ,Body Mass Index ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,NEFA ,medicine ,Humans ,Obesity ,Caloric Restriction ,media_common ,030109 nutrition & dietetics ,Nutrition and Dietetics ,medicine.diagnostic_test ,business.industry ,Cholesterol, HDL ,Appetite ,Middle Aged ,medicine.disease ,Lipids ,chemistry ,Dietary Supplements ,Body Composition ,Lipid profile ,business - Abstract
Lutein is considered as a major biologically active carotenoid, with potential benefits for obesity and cardiometabolic health. This double-blind, randomised controlled trial aimed to assess whether the consumption of lutein along with a low-calorie diet (LCD) can influence anthropometric indices, body composition and metabolic parameters in obese middle-aged individuals. After a 2-week run-in period with an LCD, forty-eight participants aged 45–65 years were randomly assigned to consume 20 mg/d lutein or placebo along with the LCD for 10 weeks. Dietary intake, anthropometric indices, body composition, lipid profile, glucose homoeostasis parameters, NEFA and appetite sensations were assessed at the beginning and end of the study. After 10 weeks, body weight and waist circumference significantly decreased in both groups, although between-group differences were not significant. There was more of a decrease in the percentage of body fat in the lutein group v. the placebo group. Moreover, the placebo group experienced a significant reduction in fat-free mass (FFM), whereas the lutein group preserved FFM during calorie restriction, although the between-group difference did not reach statistical significance. Visceral fat and serum levels of total cholesterol (TC) and LDL-cholesterol were significantly decreased only in the lutein group, with a statistically significant difference between the two arms only for TC. No significant changes were observed in the TAG, HDL-cholesterol, glucose homoeostasis parameters, NEFA and appetite sensations. Lutein supplementation in combination with an LCD could improve body composition and lipid profile in obese middle-aged individuals.
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- 2020
25. Saffron, as an adjunct therapy, contributes to relieve depression symptoms: An umbrella meta-analysis
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Meysam Zarezadeh, Zohreh Ghoreishi, Amir Hossein Faghfouri, Vali Musazadeh, Majid Keramati, and Alireza Farnam
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Pharmacology ,medicine.medical_specialty ,DASS ,ved/biology ,business.industry ,Depression ,ved/biology.organism_classification_rank.species ,Crocus ,Adjunct ,Antidepressive Agents ,Therapeutic approach ,Internal medicine ,Meta-analysis ,Crocus sativus ,Hamd ,medicine ,Humans ,Plant Preparations ,business ,Sensitivity analyses ,Depression (differential diagnoses) ,Phytotherapy - Abstract
Background Saffron is a traditional herbal medicine that has been used to treat various ailments such as depressive mood. However, the findings of several meta-analyses regarding anti-depressive properties of saffron (Crocus sativus L.) are controversial. The current umbrella meta-analysis was carried out to determine the magnitude and direction of saffron administration on depression. Methods Relevant studies were searched in international databases including PubMed, Scopus, EMBASE, Web of Science, and Cochrane Central Library up to June 2021. Meta-analysis studies investigating the effects of saffron on depression were considered to include in the study. Random-effects model was used to perform the meta-analysis. Additional analyses including subgroup and sensitivity analyses were carried out. Results Overall, 7 meta-analyses were included in the study. The results demonstrated that the consumption of saffron resulted in a significant reduction in BDI scores (ES: −3.87; 95% CI: −5.27, −2.46). However, saffron did not change the HAMD scores (ES: −2.10; 95% CI: −5.05, 0.86, p = 0.164) and mixed scores (HAM-D/BDI/DASS) (ES: 0.02; 95% CI: −0.39, 0.43,p = 0.941). Conclusion Present umbrella meta-analysis demonstrated that saffron intake might contribute to alleviation of depression disorder, however, it cannot be considered as a single therapeutic approach to treat depression.
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- 2021
26. Anti-obesity properties of probiotics; a considerable medical nutrition intervention: Findings from an umbrella meta-analysis
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Vali Musazadeh, Meysam Zarezadeh, Faezeh Ghalichi, Sana Sedgh Ahrabi, Parmida Jamilian, Parsa Jamilian, and Zohreh Ghoreishi
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Adult ,Pharmacology ,Probiotics ,Body Weight ,Dietary Supplements ,Humans ,Obesity ,Waist Circumference - Abstract
Although several studies have indicated that consumption of probiotics is effective in the treatment of obesity, the results in this regard have yielded controversial findings. The current umbrella meta-analysis was performed to evaluate the effects of probiotics supplementation on obesity indices in adults. Scopus, PubMed, Web of Science, Embase and Google Scholar were searched for relevant studies published till November 2021. Meta-analysis was conducted using the random-effects model. Sensitivity and subgroup analyses were performed. In total, 29 meta-analyses with 14,366 participants, including 112, 78, and 38 unique trials for body mass index (BMI), body weight (BW), and waist circumference (WC), were included in the study, respectively. The findings demonstrated that the probiotics supplementation was significantly effective on decreasing of BMI (ES = -0.21; 95% CI: -0.30, -0.13, p 0.001; I
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- 2022
27. Inositol supplementation and body mass index: A systematic review and meta-analysis of randomized clinical trials
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Niyaz Mohammadzadeh Honarvar, Azadeh Dehghani, Alireza Ostadrahimi, Amir Hossein Faghfouri, Nima Radkhah, Mohammad Naemi Kermanshahi, Zohreh Ghoreishi, Meysam Zarezadeh, Fatemeh Hamedi Kalajahi, and Mehrangiz Ebrahimi Mamaghani
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medicine.medical_specialty ,Nutrition and Dietetics ,business.industry ,Endocrinology, Diabetes and Metabolism ,law.invention ,chemistry.chemical_compound ,chemistry ,Randomized controlled trial ,law ,Meta-analysis ,Internal medicine ,Medicine ,Inositol ,business ,Body mass index - Abstract
Inositol is a sugar-alcohol and recognized as a key component of cell membrane phospholipids. It has crucial role in the cell signaling pathways and contribute to improving glycemic responses. Although some earlier studies have revealed the effect of inositol mediating glucose uptake by improving insulin sensitivity, the benefit of inositol supplementation in patients with overweight and obesity is not completely understood. This study aimed to assess the impact of inositol supplementation on body mass index (BMI) through a systematic review and meta-analysis of controlled clinical trials.A systematic search was performed to August 2021 in the following databases: PubMed-Medline, Embase, Web of Science and Scopus. Fifteen controlled clinical trials investigating the effect of inositol on adult's BMI were finally included in the study. A random-effects model was employed to estimate the effect size. Subgroup analysis was performed by dose, duration, age, type of inositol. Meta-regression was used to investigate presence of any linear relationship. Begg's and Egger's tests were carried out to detect small study effect.The results of pooled analysis showed that inositol supplementation significantly decreased BMI scores (WMD = -0.41 kg/mThe meta-analysis suggests that oral inositol supplementation has positive effect on BMI reduction. Inositol supplementation could be considered as an adjunct treatment to improve body mass index.
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- 2021
28. Relationship between serum spexin levels and metabolic syndrome components in obese and normal weight people with or without diabetes
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Zohreh Ghoreishi, Elham Mirzaei, Laleh Payahoo, Mohammad Asghari Jafarabadi, Ali Tarighat-Esfanjani, Hamidreza Razmi, and Mahdi Amirpour
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0301 basic medicine ,medicine.medical_specialty ,Waist ,Endocrinology, Diabetes and Metabolism ,medicine.medical_treatment ,030209 endocrinology & metabolism ,Peptide hormone ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Internal medicine ,Diabetes mellitus ,Internal Medicine ,medicine ,030109 nutrition & dietetics ,Triglyceride ,business.industry ,Insulin ,Public Health, Environmental and Occupational Health ,medicine.disease ,Blood pressure ,Endocrinology ,chemistry ,Metabolic syndrome ,business ,Body mass index - Abstract
Backgrounds & aims Spexin (SPX) as a novel polypeptide hormone plays a role in carbohydrate & lipid metabolism, energy balance, and calorie intake and it has a potential role in pathology of diabetes mellitus. Current study aimed to investigate the relationship between serum spexin levels and metabolic syndrome components in obese and normal weight people with or without diabetes. Methods Eighty-six men and eighty-two women were recruited in this study as obese and normal weight people with or without diabetes. Insulin, HbA1c, FBS, TG, TC, HDL-C, and LDL-C levels, serum SPX, weight, height, body mass index, waist and hip circumference, as well as blood pressure were measured by standard methods. Results There was a significant inverse relationship between serum levels of SPX and waist circumference (r = −0.37, P = 0.016) and triglyceride (r = −0.34, P = 0.028) in healthy people with normal weight. Moreover, a considerable relationship was observed between levels of SPX and FBS in healthy obese people (r = −0.42, P = 0.006). Conclusions There was an inverse relationship between serum SPX and three components of metabolic syndrome, including FBS levels, waist circumference values, and serum TG concentrations in people without diabetes, highlighting SPX as a potential marker of metabolic syndrome in healthy people without diabetes.
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- 2021
29. Mechanistic insights into the effect of lutein on atherosclerosis, vascular dysfunction, and related risk factors: A systematic review of in vivo, ex vivo and in vitro studies
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Vahid Maleki, Fatemeh Hajizadeh-Sharafabad, Ali Tarighat-Esfanjani, and Zohreh Ghoreishi
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0301 basic medicine ,endocrine system ,Lutein ,Anti-Inflammatory Agents ,Physiology ,Inflammation ,Blood Pressure ,Proinflammatory cytokine ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,In vivo ,Medicine ,Animals ,Humans ,Endothelial dysfunction ,Glycemic ,Pharmacology ,medicine.diagnostic_test ,business.industry ,food and beverages ,medicine.disease ,Atherosclerosis ,Lipids ,eye diseases ,030104 developmental biology ,chemistry ,030220 oncology & carcinogenesis ,Animal studies ,medicine.symptom ,business ,Lipid profile - Abstract
Lutein is an essential carotenoid commonly consumed in the diet; however, its dietary intake does not usually reach the minimum recommended intake to decrease the incidence of chronic diseases. Experimental and epidemiological evidence suggests an anti-atherosclerotic effect for lutein-rich foods or lutein supplementation. This systematic review aimed to assess the mechanistic pathways of lutein in the prevention of atherosclerosis. Electronic databases, including PubMed, SCOPUS, ProQuest, Embase, and Google Scholar were searched to May 2019. Original studies published in English-language journals that investigated the effects of lutein on atherosclerosis and related risk factors, including lipid profile, hemodynamic, glycemic and inflammatory measurements, and endothelial function indices, were considered. Two reviewers independently extracted data on study characteristics, methods and outcomes. The review protocol has been registered at PROSPERO database of Systematic Reviews (registration number: CRD42019121381). A total of 5818 articles were found in the first phase of the search; from these, 19 met the inclusion criteria: 3 in vitro, 1 ex vivo, 11 animal, and 4 human studies. Nine of ten studies showed positive effects of lutein on endothelial function by reducing blood pressure, arterial thickness, monocyte migration, and vascular smooth muscle cell migration. Twelve studies examined the anti-inflammatory properties of lutein and found a significant decrease in proinflammatory cytokines. Although few studies investigated the anti-hyperlipidemic effects of lutein, three animal studies and one clinical trial found a beneficial effect of lutein on lipid profile. Evidence supports positive effects of lutein on atherosclerosis development and some common risk factors of atherosclerosis, including inflammation and endothelial dysfunction. Further studies focused on the effects of lutein on hyperglycemia, lipid profile, blood pressure and coagulation are required.
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- 2019
30. What are the effects of N-acetylcysteine supplementation on anthropometric indices? A systematic review and meta-analysis of clinical trials
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Meysam Zarezadeh, Parisa Janmohammadi, Nazanin Hazhir Karzar, Fateme Abbaszade, Zohreh Ghoreishi, Mahtab Zarei, Alireza Ostadrahimi, Fateme Khademi, Shaghayegh Adeli, Niyaz Mohammadzadeh Honarvar, and Omid Nikpayam
- Subjects
0301 basic medicine ,Pharmacology ,medicine.medical_specialty ,030109 nutrition & dietetics ,business.industry ,Anthropometry ,medicine.disease ,Obesity ,law.invention ,Acetylcysteine ,Clinical trial ,03 medical and health sciences ,0302 clinical medicine ,Secondary outcome ,Randomized controlled trial ,law ,Internal medicine ,Meta-analysis ,medicine ,Pharmacology (medical) ,business ,Body mass index ,030217 neurology & neurosurgery ,Food Science ,medicine.drug - Abstract
Background N-acetyl cystatin (NAC) potentially can contribute to weight changes due to its antioxidant activities. Aim of the review we carried out a systematic review and meta-analysis of randomized clinical trials in order to examine whether NAC consumption can result in any changes in anthropometric indices. Methods Using appropriate keywords, we searched online databases of PubMed-Medline, SCOPUS, Web of Science, Embase databases and Google Scholar, published for relevant articles up to Nov 2019. Random-effect model was employed to report weighted mean differences. Sensitivity and subgroup analyses were carried out. Results A number of 7 eligible studies were identified. The results indicated no significant effect of NAC on BMI, weight and WC [(SMD=-0.08 Kg/m2 ; CI: -0.25, 0.08; P = 0.335, I2 = 0.0 %, P = 0.967), (SMD= -0.38 Kg; 95 % CI: -2.11, 2.87; P = 0.766, I2 = 0.0 %, P = 0.691) and (SMD= -0.22 Cm; 95 % CI: 0.52, 0.08; p = 0.153, I2 = 0.0 %, P = 0.826), respectively. No effect of sensitivity and subgroup analyses were observed. Conclusion There was no significant effect of NAC supplementation on obesity indices. As far as we assessed anthropometric factors mainly as the secondary outcome in these studies rather than the main outcome, more specific trials are suggested to assess this relationship precisely.
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- 2020
31. Risk factors for paclitaxel-induced peripheral neuropathy in patients with breast cancer
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Zahra Fathifar, Zohreh Ghoreishi, Ali Esfahani, Mohammad Asghari Jafarabadi, Karyn A. Goodman, and Seyed Ali Keshavarz
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Adult ,Oncology ,Cancer Research ,medicine.medical_specialty ,Peripheral nervous system diseases ,Paclitaxel ,Side effect ,Body Surface Area ,medicine.medical_treatment ,Receptors, progesterone ,lcsh:RC254-282 ,Body Mass Index ,law.invention ,03 medical and health sciences ,0302 clinical medicine ,Breast cancer ,Randomized controlled trial ,Risk Factors ,law ,Internal medicine ,Genetics ,medicine ,Humans ,Risk factor ,Aged ,Randomized Controlled Trials as Topic ,Chemotherapy ,business.industry ,Incidence (epidemiology) ,Age Factors ,Middle Aged ,lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,medicine.disease ,Antineoplastic Agents, Phytogenic ,Peripheral neuropathy ,030220 oncology & carcinogenesis ,Female ,Breast neoplasms ,business ,Body mass index ,030217 neurology & neurosurgery ,Research Article - Abstract
Background Paclitaxel induced peripheral neuropathy (PIPN) is a major debilitating side effect of paclitaxel in patients with breast cancer with no fully known mechanisms. The aim of the study was to find out the possible risk factors for PIPN. Methods Eligible patients with node positive breast cancer undergoing chemotherapy with paclitaxel were assessed. They belonged to an initial randomized controlled trial in which the effectiveness of omega-3 fatty acids in preventing and reducing severity of PIPN was evaluated (protocol ID: NCT01049295). Reduced total neuropathy score (r-TNS) was used for measuring PIPN. All analyses were performed adjusting for intervention effect. The association between age, BMI, BSA, pathological grade, molecular biomarkers and PIPN was evaluated. Results Fifty-seven patients with breast cancer were investigated. Age was significantly associated with risk of PIPN (RR:1.50, P value = .024). Body mass index and BSA had significant association with severity of PIPN (B:1.28, P = .025; and B: 3.88, P = .010 respectively). Also, BSA showed a significant association with the risk of PIPN (RR: 2.28, P = .035; B: 3.88, P = .035). Incidence and severity of PIPN were much more pronounced in progesterone receptor positive (PR+) patients (RR:1.88, P = .015 and B:1.54, P = .012). Multivariate analysis showed that age and the status of PR+ were independent risk factor for incidence and the status of PR+ was the only independent risk factor for severity of PIPN. Conclusion Age, BSA and the status of PR+, should be considered as the risk factors for PIPN before commencement of chemotherapy with paclitaxel in patients with breast cancer. Older patients, those with greater BSA and PR+ patients may need closer follow up and more medical attention due to greater incidence and severity of PIPN.
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- 2018
32. A new score for screening of malnutrition in patients with inoperable gastric adenocarcinoma
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Alireza Ostadrahimi, Mousa Ghayour Nahand, Zahra Fathifar, Mohammad Hossein Somi, Akram Doostzadeh, Mohammad Asghari Jafarabadi, Ali Esfahani, and Zohreh Ghoreishi
- Subjects
Oncology ,Male ,Cancer Research ,medicine.medical_specialty ,Nutritional Status ,Adenocarcinoma ,Gastroenterology ,03 medical and health sciences ,0302 clinical medicine ,Carcinoembryonic antigen ,Quality of life ,Stomach Neoplasms ,Internal medicine ,medicine ,Humans ,Mass Screening ,Radiology, Nuclear Medicine and imaging ,030212 general & internal medicine ,Tumor marker ,Aged ,Inflammation ,biology ,business.industry ,C-reactive protein ,Malnutrition ,Albumin ,Cancer ,General Medicine ,Middle Aged ,medicine.disease ,Chemotherapy regimen ,Nutrition Assessment ,ROC Curve ,030220 oncology & carcinogenesis ,biology.protein ,Female ,business ,Biomarkers - Abstract
Background Malnutrition is common in patients with gastric cancer. Early identification of malnourished patients results in improving quality of life. We aimed to assess the nutritional status of patients with inoperable gastric adenocarcinoma (IGA) and finding a precise malnutrition screening score for these patients before the onset of chemotherapy. Methods Nutritional status was assessed using patient generated subjective global assessment (PG-SGA), visceral proteins, and high-sensitivity C reactive protein. Tumor markers of carcinoembryonic antigen (CEA), carbohydrate antigen 125 (CA-125) and CA 19-9 and their association with nutritional status were assessed. Then a new score for malnutrition screening was defined. Results Seventy-one patients with IGA completed the study. Malnourished and well-nourished patients (based on PG-SGA) were statistically different regarding albumin, prealbumin and CA-125. The best cut-off value for prealbumin for prediction of malnutrition was determined at 0.20 mg/dl and using known cut-off values for albumin (3.5 g/dl) and CA-125 (35 U/ml), a new score was defined for malnutrition screening named MS-score. According to MS-score, 92% of the patients had malnutrition and it could predict malnutrition with 96.8% sensitivity, 50% specificity and accuracy of 91.4%. Conclusion MS-score has been suggested as an available and easy-to-use tool for malnutrition screening in patients with IGA.
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- 2016
33. MON-PO538: Cross Cultural Adaptation and Validation of the ‘Patient-Generated Subjective Global Assessment (PG-SGA)’ for Nutritional Status Assessment of Cancer Patients in Iran
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Faith D. Ottery, M. Asghari Jafarabadi, J. Shahabbasi, Harriët Jager-Wittenaar, Roya Dolatkhah, Saeid Dastgiri, and Zohreh Ghoreishi
- Subjects
Gerontology ,Nutrition and Dietetics ,business.industry ,medicine ,Cancer ,Cross-cultural ,Nutritional status ,Critical Care and Intensive Care Medicine ,Adaptation (computer science) ,medicine.disease ,business - Published
- 2019
34. Association of CDX2 expression and overall survival and clinicopathologic disease manifestations in patients with gastric cancer in Northwest of Iran
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Farideh Akbari, Zohreh Ghoreishi, Babak Nejati, Ali Esfahani, Khatereh Rezazadeh, and Mohammad Asghari Jafarabadi
- Subjects
medicine.medical_specialty ,Endocrinology, Diabetes and Metabolism ,Immunology ,lcsh:Medicine ,Clinicopathologic characteristics ,Disease ,Malignancy ,Gastroenterology ,Metastasis ,Carcinoembryonic antigen ,Immunology and Microbiology (miscellaneous) ,Internal medicine ,medicine ,Overall survival ,Stage (cooking) ,CDX2 ,biology ,Homeobox protein CDX2 ,business.industry ,lcsh:R ,Cancer ,Hematology ,medicine.disease ,digestive system diseases ,embryonic structures ,biology.protein ,Immunohistochemistry ,Gastric cancer ,business - Abstract
Introduction: In the northwest of Iran, gastric cancer is the first and third common form of malignancy in men and women, respectively. Homeobox protein CDX2, was proposed as a prognostic biomarker in gastric cancer. Objectives: This study aimed to assess the association of CDX2 expression overall survival as well as clinicopathologic variables in patients with gastric cancer. Materials and Methods: CDX2 expression was examined by the immunohistochemistry method in the formalin-fixed paraffin-embedded surgical specimens of gastric cancer. The association between CDX2 expression and overall survival, stage of the disease, metastasis status, pathology type of the tumor, and serum levels of tumor markers serum levels of tumor markers carcinoembryonic antigen (CEA), cancer antigen 125 (CA-125), cancer antigen 19-9 (CA 19-9) was then evaluated. Results: Ninety-two patients with primary gastric cancer were recruited. CDX2 expression was positive in 72 (78%) of the subjects. Overall survival was not significantly different between two groups of patients (CDX2 positive versus negative). However, the risk of death was 21% lower in CDX2 positive patients, after adjusting for age and gender (P=0.565). Disease stage and metastasis rate were significantly lower in CDX2 positive patients (P=0.027, and P=0.021, respectively). Additionally, 71% of the CDX2 positive subjects had intestinal pathology type of the disease (P=0.025). Accordingly, a significant lower level of CA19-9 was found in CDX2 positive patients as well (P=0.002). Conclusion: There was not any significant association between CDX2 expression and overall survival in patients with gastric cancer, although the risk of death was lower in CDX2 positive subjects. However, there was a less invasive pattern of gastric carcinoma in this group of patients.
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- 2019
35. Nutritional assessment of patients with acute leukemia during induction chemotherapy: association with hospital outcomes
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Mousa Ghayour Nahand, Zohreh Sanaat, Alireza Ostadrahimi, Heidarali Esmaili, Jamal Eivazi Ziaei, Mohammad Asghari Jafarabadi, Yashar Sorusheh, Zohreh Ghoreishi, Mahdi Abedi Miran, and Ali Esfahani
- Subjects
Adult ,Male ,Cancer Research ,medicine.medical_specialty ,Adolescent ,Body Mass Index ,Young Adult ,hemic and lymphatic diseases ,Internal medicine ,Antineoplastic Combined Chemotherapy Protocols ,Outcome Assessment, Health Care ,medicine ,Humans ,Serum Albumin ,Aged ,Febrile Neutropenia ,Acute leukemia ,business.industry ,Malnutrition ,Transferrin ,Neutropenic fever ,Myeloid leukemia ,Induction chemotherapy ,Induction Chemotherapy ,Hematology ,Length of Stay ,Middle Aged ,Precursor Cell Lymphoblastic Leukemia-Lymphoma ,medicine.disease ,Surgery ,Leukemia, Myeloid, Acute ,C-Reactive Protein ,Cross-Sectional Studies ,Nutrition Assessment ,Oncology ,Toxicity ,business ,Hospital stay ,Body mass index - Abstract
Cancer-related malnutrition causes morbidity and reduced survival. The aim of this study was to evaluate the nutritional and inflammatory status of patients with acute leukemia in association with duration of neutropenic fever (DNF) and length of hospital stay (LHS) during induction chemotherapy. Fifty-five patients with acute lymphoblastic leukemia (ALL) (n = 28) and acute myeloid leukemia (AML) (n = 27) completed the study. There were significant differences between the two groups according to LHS and DNF (p = 0.022 and p = 0.012, respectively): both had a longer period in patients with AML. The patients were statistically different according to body mass index (BMI), pre-albumin, high-sensitivity C-reactive protein (hs-CRP) and patient-generated subjective global assessment (PG-SGA) score (p = 0.049, p = 0.028, p < 0.001, p = 0.030). In patients with ALL, serum albumin and pre-albumin levels were associated with LHS and DNF, respectively. Moreover, PG-SGA score was associated with DNF. In patients with AML, BMI and second pre-albumin level < 10 mg/dL were associated with DNF. Pre-albumin was the common indicator for chemotherapy-related complications in patients with both ALL and AML. Early nutritional assessment can help to find patients with acute leukemia who need nutritional support, and it may contribute to better outcome and less toxicity.
- Published
- 2013
36. Prealbumin/CRP Based Prognostic Score, a New Tool for Predicting Metastasis in Patients with Inoperable Gastric Cancer
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Elnaz Faramarzi, Alireza Ostadrahimi, Ali Esfahani, Nima Makhdami, Zohreh Ghoreishi, Mousa Ghayour Nahand, and Mohammad Asghari Jafarabadi
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Oncology ,medicine.medical_specialty ,Article Subject ,medicine.medical_treatment ,education ,Bioinformatics ,Prognostic score ,Metastasis ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,medicine ,In patient ,030212 general & internal medicine ,lcsh:RC799-869 ,Chemotherapy ,Hepatology ,biology ,business.industry ,C-reactive protein ,Gastroenterology ,Cancer ,medicine.disease ,Transthyretin ,Sample size determination ,030220 oncology & carcinogenesis ,biology.protein ,lcsh:Diseases of the digestive system. Gastroenterology ,business ,Research Article - Abstract
Background.There is a considerable dissimilarity in the survival duration of the patients with gastric cancer. We aimed to assess the systemic inflammatory response (SIR) and nutritional status of these patients before the commencement of chemotherapy to find the appropriate prognostic factors and define a new score for predicting metastasis.Methods.SIR was assessed using Glasgow Prognostic Score (GPS). Then a score was defined as prealbumin/CRP based prognostic score (PCPS) to be compared with GPS for predicting metastasis and nutritional status.Results.71 patients with gastric cancer were recruited in the study. 87% of patients had malnutrition. There was a statistical difference between those with metastatic (n=43) and those with nonmetastatic (n=28) gastric cancer according to levels of prealbumin and CRP; however they were not different regarding patient generated subjective global assessment (PG-SGA) and GPS. The best cut-off value for prealbumin was determined at 0.20 mg/dL and PCPS could predict metastasis with 76.5% sensitivity, 63.6% specificity, and 71.4% accuracy. Metastatic and nonmetastatic gastric cancer patients were different in terms of PCPS (P=0.005).Conclusion.PCPS has been suggested for predicting metastasis in patients with gastric cancer. Future studies with larger sample size have been warranted.
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- 2016
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37. Effect of vitamin E on chemotherapy-induced mucositis and neutropenia in leukemic patients undergoing bone marrow transplantation
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Masoud Iravani, Ali Esfahani, Zohreh Ghoreishi, Farzad Shidfar, and Ardeshir Ghavamzadeh
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medicine.medical_specialty ,business.industry ,Vitamin E ,medicine.medical_treatment ,General Medicine ,Neutropenia ,medicine.disease ,Placebo ,Gastroenterology ,Surgery ,Clinical trial ,Leukemia ,Myelogenous ,Oncology ,hemic and lymphatic diseases ,Internal medicine ,medicine ,Mucositis ,business ,Chronic myelogenous leukemia - Abstract
Aim: This study was conducted to investigate the effect of oral vitamin E on mucositis and neutropenia in patients with leukemia. Methods: This was a randomized double-blind placebo controlled clinical trial of 60 patients with leukemia (acute lymphoblastic, acute myelogenous leukemia and chronic myelogenous leukemia) who were consecutive recipients of allogenic bone marrow transplantation (BMT), randomly assigned to receive 400 mg vitamin E twice daily (supplemented group) or placebo (control). The incidence and severity of mucositis and the mean duration of neutropenia were compared. Results: The mean duration of neutropenia and the incidence of the mucositis between the two groups was the same (P = 1.0). The difference between the placebo group and mucositis grade 1 (P = 0.31), grade 2 (P = 0.25), grade 3 (P = 0.93) and grade 4 (P = 0.32) was not statistically significant. Moreover the variables of age, sex, BMI and underlying disease had no effect. Conclusion: In this study supplementation with oral vitamin E had no effect on mucositis and neutropenia in patients with leukemia who were recipients of allogenic BMT. More interventional trials are warranted.
- Published
- 2007
38. Association of age and body mass index with paclitaxel-induced peripheral neuropathy in patients with breast cancer
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Zohreh Ghoreishi, Ali Esfahani, and Seyed Ali Keshavarz
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Oncology ,medicine.medical_specialty ,business.industry ,Hematology ,medicine.disease ,chemistry.chemical_compound ,Breast cancer ,Peripheral neuropathy ,Paclitaxel ,chemistry ,Internal medicine ,medicine ,In patient ,business ,Body mass index - Published
- 2016
39. Is there any association between vitamin D receptor polymorphisms and acute myeloid leukemia?
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Zohreh Ghoreishi and Ali Esfahani
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Oncology ,business.industry ,Immunology ,Myeloid leukemia ,Medicine ,Hematology ,business ,Calcitriol receptor - Published
- 2016
40. Progesterone receptor, a novel risk factor for paclitaxel-induced peripheral neuropathy
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Zohreh Ghoreishi, Hormoz Ayromlou, Ali Esfahani, and Mohammad Asghari Jafarabadi
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Oncology ,Cancer Research ,medicine.medical_specialty ,Pathology ,Progesterone receptor A ,business.industry ,medicine.disease ,chemistry.chemical_compound ,Breast cancer ,Peripheral neuropathy ,Paclitaxel ,chemistry ,Internal medicine ,mental disorders ,medicine ,business ,Complication - Abstract
e12031Background: Peripheral neuropathy is the main dose-limiting complication of paclitaxel. In this study, the association between clinical characteristics of the patients with breast cancer, dis...
- Published
- 2016
41. Tumor necrosis factor alpha, a neurotoxic proinflammatory cytokine for oxaliplatin-induced peripheral neuropathy
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Zohreh Ghoreishi, Ali Esfahani, Hormoz Ayromlou, and Mohammad Asghari Jafarabadi
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Cancer Research ,Side effect ,business.industry ,Colorectal cancer ,Incidence (epidemiology) ,medicine.disease ,digestive system diseases ,Proinflammatory cytokine ,Oxaliplatin ,Peripheral neuropathy ,Oncology ,Cancer research ,medicine ,Tumor necrosis factor alpha ,business ,neoplasms ,medicine.drug - Abstract
e15095Background: Colorectal cancer (CRC) has a progressive incidence throughout the world and peripheral neuropathy is the major dose-limiting side effect of oxaliplatin, a chemotherapeutic agent ...
- Published
- 2016
42. 2379 Prealbumin/CRP based prognostic score, a new tool for predicting metastasis in patients with inoperable gastric cancer
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M. Asghari Jafarabadi, Zohreh Ghoreishi, and Ali Esfahani
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Oncology ,Cancer Research ,medicine.medical_specialty ,biology ,business.industry ,Cancer ,medicine.disease ,Prognostic score ,Metastasis ,Transthyretin ,Internal medicine ,medicine ,biology.protein ,In patient ,business - Published
- 2015
43. N-3 polyunsaturated fatty acids: Prophylaxis and symptomatic therapy for oxaliplatin-induced peripheral neuropathy—A randomized, double-blind placebo controlled trial
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Mohammad Hossein Somi, Hormoz Ayromlou, Mohammad Asghari Jafarabadi, Zohreh Ghoreishi, and Ali Esfahani
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chemistry.chemical_classification ,Cancer Research ,medicine.medical_specialty ,Side effect ,business.industry ,Placebo-controlled study ,medicine.disease ,Neuroprotection ,Gastroenterology ,digestive system diseases ,Oxaliplatin ,Surgery ,Double blind ,stomatognathic diseases ,Peripheral neuropathy ,Oncology ,chemistry ,health services administration ,Internal medicine ,medicine ,business ,therapeutics ,neoplasms ,medicine.drug ,Polyunsaturated fatty acid - Abstract
e14504 Background: Oxaliplatin induced peripheral neuropathy (OXIPN) is the major dose-limiting side effect of oxaliplatin. N-3 PUFAs have known neuroprotective property. This study was a randomize...
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- 2015
44. The effects of omega-3 fatty acids on chemotherapy-induced neuropathy and inflammation in patients with breast cancer
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Bina Eftekharsadat, Zohreh Ghoreishi, Ali Esfahani, and Mohammad Asghari Jafarabadi
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Oncology ,Cancer Research ,medicine.medical_specialty ,Side effect ,business.industry ,Inflammation ,medicine.disease ,chemistry.chemical_compound ,Breast cancer ,Paclitaxel ,chemistry ,Chemotherapy induced ,Internal medicine ,medicine ,In patient ,medicine.symptom ,business ,Beneficial effects - Abstract
1039 Background: Axonal sensoryperipheral neuropathy is the major dose-limiting side effect of paclitaxel. Omega-3 fatty acids have beneficial effects on neurological disorders from their effects o...
- Published
- 2014
45. 1014 POSTER Influence of Chemotherapy on the Lipid Peroxidation and Antioxidant Status in Patients With Acute Myeloid Leukemia
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Zohreh Ghoreishi, Zohreh Sanaat, Ali Esfahani, Amir Ghorbanihaghjo, and Alireza Nikanfar
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Cancer Research ,Chemotherapy ,Antioxidant ,business.industry ,medicine.medical_treatment ,Myeloid leukemia ,Pharmacology ,Lipid peroxidation ,chemistry.chemical_compound ,Oncology ,chemistry ,medicine ,In patient ,business - Published
- 2011
46. Assesment of bone loss after bone marrow transplantation in patients with leukemia and lymphoma
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Ahmad Reza Shamshiri, A. Ghavamzadeh, Massoud Iravani, Ali Esfahani, Zohreh Ghoreishi, and M. Khoushniat
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Transplantation ,Leukemia ,Pathology ,medicine.medical_specialty ,Bone marrow transplantation ,business.industry ,Medicine ,In patient ,Hematology ,business ,medicine.disease ,human activities ,Lymphoma - Published
- 2006
47. The effect of n-3 polyunsaturated fatty acids on incidence and severity of oxaliplatin induced peripheral neuropathy: a randomized controlled trial
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Bina Eftekhar Sadat, Hormoz Ayromlou, Alireza Nikanfar, Mohammad Asghari Jafarabadi, Zohreh Ghoreishi, Ali Esfahani, and Mohammad Hossein Somi
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medicine.medical_specialty ,Side effect ,Colorectal cancer ,medicine.medical_treatment ,Clinical Biochemistry ,Placebo-controlled study ,Placebo ,Gastroenterology ,law.invention ,03 medical and health sciences ,0302 clinical medicine ,Randomized controlled trial ,law ,Internal medicine ,medicine ,Chemotherapy ,business.industry ,Research ,Biochemistry (medical) ,medicine.disease ,Oxaliplatin ,Colon cancer ,n-3 polyunsaturated fatty acids ,Neuropathy ,Peripheral neuropathy ,030220 oncology & carcinogenesis ,Anesthesia ,Molecular Medicine ,business ,030217 neurology & neurosurgery ,medicine.drug - Abstract
Background Oxaliplatin induced peripheral neurotoxicity (OXIPN) is the major dose-limiting and long-lasting side effect of oxaliplatin. N-3 PUFAs have neuroprotective property via their effects on voltage-gated ion channels and by reducing the production of proinflammatory cytokines that causes neuropathy. This study was a randomized double blind placebo controlled trial to find the possible advantages of n-3 PUFAs for preventing and reducing the severity of OXIPN in patients with colon cancer. Methods Eligible patients with colon cancer randomly allocated to take n-3 PUFAs pearls, 640 mg t.i.d during chemotherapy with oxaliplatin and one month after the cessation of the treatment or placebo. All patients were evaluated for incidence and severity of OXIPN based on “reduced Total Neuropathy Score” in which clinical and electrophysiological assessments were included. Results Seventeen patients (47 %) of the n-3 PUFA supplemented group (n = 36) did not develop PN while it was 11 %(4 patients) in the placebo group (n = 35). There was a significant difference in PN incidence (OR = 0.14, .95 % CI = (0.04 to 0.49), p = 0.002). The difference of OXIPN severity was significant between the two study groups (B = −1.61, 0.95 % CI = (−2.59 to −0.62), p = 0.001). Conclusions N-3 PUFAs may have neuroprotective effect for reducing the incidence and severity of OXIPN. Finding an effective prophylactic or symptomatic therapy for OXIPN would significantly improve the patients’ quality of life. Trial registration IRCT201112158397N2
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48. Omega-3 fatty acids are protective against paclitaxel-induced peripheral neuropathy: A randomized double-blind placebo controlled trial
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Shahriar Hashemzade, Mohammad Asghari Jafarabadi, Mahmoud Djalali, Seyed Ali Keshavarz, Hormoz Ayromlou, Ali Esfahani, Vahid Montazeri, Banafsheh Golestan, Abolghasem Djazayeri, Zohreh Ghoreishi, and Masoud Darabi
- Subjects
Adult ,medicine.medical_specialty ,Cancer Research ,Paclitaxel ,Peripheral neuropathy ,Side effect ,medicine.medical_treatment ,Neural Conduction ,Placebo-controlled study ,Breast Neoplasms ,Placebo ,lcsh:RC254-282 ,Gastroenterology ,law.invention ,Breast cancer ,Randomized controlled trial ,law ,Internal medicine ,Fatty Acids, Omega-3 ,Omega-3 fatty acids ,medicine ,Genetics ,Humans ,chemistry.chemical_classification ,Chemotherapy ,business.industry ,Peripheral Nervous System Diseases ,Fatty acid ,Middle Aged ,lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,medicine.disease ,Antineoplastic Agents, Phytogenic ,Surgery ,Clinical trial ,Neuroprotective Agents ,Treatment Outcome ,chemistry ,Oncology ,Dietary Supplements ,Female ,business ,Research Article - Abstract
Background Axonal sensory peripheral neuropathy is the major dose-limiting side effect of paclitaxel.Omega-3 fatty acids have beneficial effects on neurological disorders from their effects on neurons cells and inhibition of the formation of proinflammatory cytokines involved in peripheral neuropathy. Methods This study was a randomized double blind placebo controlled trial to investigate the efficacy of omega-3 fatty acids in reducing incidence and severity of paclitaxel-induced peripheral neuropathy (PIPN). Eligible patients with breast cancer randomly assigned to take omega-3 fatty acid pearls, 640 mg t.i.d during chemotherapy with paclitaxel and one month after the end of the treatment or placebo. Clinical and electrophysiological studies were performed before the onset of chemotherapy and one month after cessation of therapy to evaluate PIPN based on "reduced Total Neuropathy Score". Results Twenty one patients (70%) of the group taking omega-3 fatty acid supplement (n = 30) did not develop PN while it was 40.7%( 11 patients) in the placebo group(n = 27). A significant difference was seen in PN incidence (OR = 0.3, .95% CI = (0.10-0.88), p = 0.029). There was a non-significant trend for differences of PIPN severity between the two study groups but the frequencies of PN in all scoring categories were higher in the placebo group (0.95% CI = (−2.06 -0.02), p = 0.054). Conclusions Omega-3 fatty acids may be an efficient neuroprotective agent for prophylaxis against PIPN. Patients with breast cancer have a longer disease free survival rate with the aid of therapeutical agents. Finding a way to solve the disabling effects of PIPN would significantly improve the patients’ quality of life. Trial registration This trial was registered at ClinicalTrials.gov (NCT01049295)
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49. Influence of chemotherapy on the lipid peroxidation and antioxidant status in patients with acute myeloid leukemia
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Esfahani A, Zohreh Ghoreishi, Nikanfar A, Sanaat Z, and Ghorbanihaghjo A
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Adult ,Male ,Glutathione Peroxidase ,lcsh:R5-920 ,Acute myeloid leukemia ,Superoxide Dismutase ,Daunorubicin ,Cytarabine ,Middle Aged ,Antioxidants ,Leukemia, Myeloid, Acute ,Oxidative stress ,Malondialdehyde ,Antineoplastic Combined Chemotherapy Protocols ,Humans ,Chemotherapy ,Female ,Lipid Peroxidation ,Antioxidant ,lcsh:Medicine (General) - Abstract
Chemotherapeutic agents used in patients with cancer cause to generate the enormous amounts of free radicals associated with cell injury. In this study we assess the effects of chemotherapy regimen on oxidant/antioxidant status in patients with acute myeloid leukemia (AML). 38 newly diagnosed patients with acute myeloid leukemia were recruited in this study. All patients received cytarabine and daunorubicin as chemotherapy regimen. Plasma levels of malondialdehyde (MDA), total antioxidant status (TAS), and the levels of erythrocyte activity of superoxide dismutase (SOD) and glutathione peroxidase (GPx) were determined before chemotherapy and 14 days after chemotherapy with cytarabine and daunorubicin. Plasma MDA concentrations increased significantly (from 2.68 ± 0.89 nmol/L to 3.14 ± 1.29 nmol/L) during the 14 days post-chemotherapy period (P=0.04). Plasma TAS concentrations changed with chemotherapy from 1.09 ± 0.15 mmol/L to 1.02 ± 0.14 mmol/L with P=0.005. Erythrocyte SOD and GPX activity decreased overtime from 1157.24 ± 543.61 U/g Hb to 984.01 ± 419.09 U/g Hb (P=0.04) and 46.96 ± 13.70 U/g Hb to 41.40 ± 6.44 U/g Hb (P=0.02) respectively. We report here that there is an increase in malondialdehyde levels and a decrease in the levels of antioxidant enzymes and total antioxidant status. This suggests that chemotherapy causes these changes as a result of enormous production of reactive oxygen species in the patients with AML. Antioxidant supplementation must be approached with caution because of the probability of reduction the therapeutic efficacy of these cytotoxic drugs.
50. Omega-3 Fatty Acids and Chemotherapy-induced Neuropathy and Inflammation in Breast Cancer
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Zohreh Ghoreishi, Master of Nutrition
- Published
- 2011
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