Search

Computational fluid dynamics is a compelling apparatus for getting stream flow and anticipating how this flow will react to various limiting boundary conditions. With this learning, the focal point of this research is applying computational fluid elements such as CFD to issues dealing with stream flow measurement/estimation in closed conduits such as pipes utilizing differential stream meters like the Venturi meter. After thorough research from the existing literature, it was determined that the convergent angle (CA) of a standard Venturi meter has not been optimized yet. The range given for a standard ASME Venturi CA is 20–22°. More than 50 models were created and run in ANSYS FLUENT, which was used as a CFD tool. Three β-ratios are taken into consideration here, which are 0.4, 0.5 and 0.6. An optimum value of CA, corresponding to each β, is obtained by finding out the best coefficient of discharge (closest to 0.99) for each test value of CA. Another aspect explored in this research is the relationship between Reynolds number and coefficient of discharge. This is done with the integration of ANSYS FLUENT and laboratory results. The results of this study yield a definite value of CA for each β.

Neonatal diabetes is estimated to affect 1 in every 95,000 to 1 in every 400,000 live births. Male and female infants are equally affected by the disease, which has been recorded in all ethnic groups. Neonatal diabetes mellitus is a type of diabetes that develops within the first six months of life. Insulin is a hormone that aids in the production of energy in our cells. This condition causes infants to produce insufficient insulin, resulting in elevated blood glucose levels. Therefore, it is very important to design a testing device that can monitor premature babies indicating symptoms of diabetes. Recognizing the signs of diabetes in an infant might be difficult because diabetes in babies is not common. Frequent wet diapers, a high appetite, dehydration, and weight loss are all signs of neonatal diabetes. Once you have diabetes, you're used to having to take tests to monitor your condition. Conventionally invasive methods are used to check neonatal diabetes which is a painful procedure for infants as it requires prinking to draw blood several times per day. Therefore, this paper aims to design a non-invasive testing design for neonatal diabetes that is not painful to babies. There are several non-invasive ways to test blood glucose levels; urine, sweat, and saliva. Urine tests can be used to detect glucose levels in urine and check for the presence of ketones. The presence of ketone above the threshold indicates a high blood glucose level of over 300ml/dL. Sweat is also used to test diabetes. Hyperhidrosis (excessive sweating) is caused by high blood sugar levels, and it indicates that blood sugar control has to be tightened. Saliva is a new medium to measure blood glucose levels and research is going on its use to measure diabetes. Previous research has found a strong relationship between blood glucose levels and saliva glucose levels. In this paper, saliva is used as a non-invasive method to measure neonatal diabetes. Saliva containing glucose is collected and treated with glucose oxidase. H2O2 produced during this reaction is further treated and an optical sensor along with a microcontroller is used to measure the concentration of blood glucose. The expected results based on the study indicate the amount of glucose in the saliva increases in proportion to the amount of glucose in the blood and confirms the relationship between glucose concentrations in the blood and saliva, implying that the proposed design can take the place of the existing devices. However, more tests should be carried out to improve the efficacy of the proposed design for detecting glucose in saliva.

In hospitals the monitoring of patient is usually done manually with the help of nursing staff for 24 x 7. The availability of nursing staff to monitor the health of critically ill patients or new born infant is very difficult task and requires a lot of man power. In case, of absence or delay the health of patient can become critical and can be fatal. In order to solve this many wireless technologies have been proposed to monitor the patient’s condition using different sensors but these wireless schemes are harmful for patients/infants and can even interface with medical devices. In order to develop hospital friendly monitoring system, Li-Fi based health monitoring-based system has been proposed which measure the heart rate, temperature and motion in case of infants and the data is continuously displayed on LCD. In case of any abnormalities, the relevant staff will be notified.

Kerala's Idukki district, which is situated on the Western Ghats of India, is susceptible to flooding and landslides. As a result of the 2018 Kerala floods, this disaster-prone region experienced drought conditions. In order to lessen the effects of future disasters, it is also necessary to identify and evaluate the district's groundwater potential (GWP). This work used three machine-learning (ML) algorithms – Random Forest (RF), Adaptive Boosting (AdaBoost), and Gradient Boosting (GB) – to model and produce GWP zonation maps for the Idukki district. Fourteen conditioning factors include elevation, slope, curvature, Topographic Roughness Index, lineament density, soil, geology, geomorphology, Topographic Wetness Index, Sediment Transport Index, drainage density, rainfall, land-use/land-cover (LULC), and Normalised Difference Vegetation Index that were adopted as input parameters in the modelling. All showed prominence when they were examined for feature importance using the recursive feature elimination (RFE) method. The RF model outperformed the other two ML models in terms of fit, with an area under curve (AUC) value of 0.92, while the GB and AdaBoost models displayed less fit, with AUC values of 0.90 and 0.88, respectively. GWP maps produced by each model were reclassified into five zones – very high to very low – it was discovered that the zones were evenly spread throughout the Idukki region.

Solar-Powered Smart Irrigation System (SPSIS) is a solution to many problems of the agricultural system. In this work, a solar-powered smart irrigation solution is proposed for the farmers of Pakistan facing energy crises. The proposed smart irrigation system is powered by renewable solar energy, which is equipped with solar panel modules to convert sunlight into electrical energy. Arduino microcontroller-based system is designed for automatic operation of the complete system. Due to the automatic working of the proposed system, it will be better than a conventional irrigation system in terms of human effort, time, water and energy consumption to operate the irrigation system. The proposed Solar-Powered Smart Irrigation System (SPSIS) does not rely on grid power due to its self-energy production using solar power, resulting in a significant reduction of power usage from grid power. The proposed SPSIS is equipped with multiple input soil moisture sensors, which measure the humidity of the soil. SPSIS is also equipped with a monitoring setup to intimate the farmers about the water level in the field and the irrigation status of the field. Furthermore, SPSIS is also equipped with an automatic spray system to prevent weeds, insects and pests in the crops. Additionally, a GSM Module has also been added to the overall system for the intimation/controlling of the irrigation process through text messages. Such an implementation of a solar-powered smart irrigation system with additional features of automatic spray and monitoring and control using GSM will be highly beneficial for the formers in terms of power, efforts and resources required for irrigation, spray and monitoring of the crop.

Medicinal plants have been used with practical implementation of certain herbal great source of plant based flavonoids, antioxidants compounds. Medicinal plants were traditionally used for health care and serve as the bases for the emergence of modern medicine. They have possess the high quality of the extracts to evaluate their therapeutic efficacy for their pharmacological action. Large variety of medicinal plants have been used as aromatic purposes and hence valuate for aroma and pharmacological sectors. Medicinal plants snowed stronger binding to the proteins secreted by the parasitic worms thus inhibiting them to proliferate in the cellular tissues thus acting as main source of immunity booster to the living tissues against the dyspepsia, gastritis, hyperacidity, menorrhagia, diabetes. Saraca asoca also used as source of medicinal pant due to its to antibacterial activity because of its potential against the of multiple bacterial strains. Some of the medicinal plants acting as dual nature such as targeting the microbial proteins and peptides playing important role in the development of natural therapies. Nanoparticles based therapies can be utilized for treatment of infectious diseases.

Objective: To determine the frequency of dyslipidemia and its types in adult diabetics of Karachi. Study Design: Cross Sectional, Observational study. Setting: Diabetic Outpatient Clinic in JPMC, Karachi. Period: January 2019 to June 2019. Material & Methods: 248 adult diabetics presenting in diabetic outpatient clinic in JPMC, Karachi selected by non-purposive convenient sample technique. Diagnosed diabetics who were not on any lipid lowering therapy were included in the study. Non diabetics and those diabetics who are already on lipid lowering drugs were excluded. After relevant information is taken the lipid profile of the participants was done with a 12 hours fasting and the data was secured on a pre-designed performa. The results were analyzed on SPSS. Results: Among the 248 diabetics that presented 88(35.4%) were males and 160(64.5%) were females. The prevalence of dyslipidemia is 85.9% (213 diabetics had dyslipidemia). High triglycerides were present in 52.4% (130), high LDL in 28.2% (70) and low HDL in 175(70.6%). [P=0.000]. At least one dyslipidemic factor was deranged in 81(32.7%), two in 102(41.1%) and 3 in 30(12.1%) persons. In males, 53 out of 88(60.2%) were dyslipidemic, and in females all had dyslipidemia (100%). [P = 0.000]. Hypertriglyceridemia was present in 38(43.1%) males and 92(57.5%) females [P=.021], High LDL in 21(23.8%) males and 49(44%) females [P=.163], while low HDL was present in 16(22%) males and 159(99%) females [P=.000]. Conclusion: Dyslipidemia is highly prevalent in our population. Female diabetic patients had relatively higher triglycerides than men.

Objective: The main objective is to elaborate and discuss different techniques used in data mining, to analyze different strategies of data mining to make improvements, and to find more powerful mining techniques for the betterment of the business. Methods: Multiple techniques and strategies of data mining are used to improve the business. We employed the data warehouse methods for the improvements of the business using Business Intelligence (BI) and Business Analytics (BA) along with their types and instruments. We are also discussing some tools used for data mining or ordering organizational data. Findings: We employed Business Intelligence-(BI) and Business Analytics-(BA) techniques for the improvement of the business. Earlier, there were only four (Regression, Classification, Association, and Clustering) techniques that were used for business improvements. It is found that Crawler is the best tool for BI or BA data mining. Novelty : This study analyzed that, BI and BA are the best ways used for data mining, data ordering, or format of data in business. Earlier, these ways were not in use for data mining. Data mining may be the best approach to improve the business. Keywords: Business Intelligence (BI); Business Analytics Data Mining (BADM); Data Warehouse (DW); Knowledge Discovery (KDD) Customer Relationship Management (CRM); Enterprise Resource Planning (ERP)

Background: Polycystic ovary syndrome (PCOS) is the most frequent pathology among women of reproductive age characterized by menstrual irregularities, hyperandrogenism and polycystic ovaries on ultrasound. Evidence suggests that high androgen levels are the fundamental factor in the pathogenesis of PCOS. The objectives of the present study was to determine serum free testosterone levels in polycystic ovarian syndrome patients, and observe its correlation with clinical hyperandrogenism. Patients and methods: This cross-sectional study was conducted at Jinnah Allama Iqbal Institute of Diabetes and Endocrinology Lahore, Pakistan from 15th May 2019 to 15th November 2019. The study included 140 patients of PCOS diagnosed as per Rotterdam criteria. Serum testosterone levels were determined in these patients by ELISA method. Ferriman-Gallwey (FG) score was used to assess severity of clinical hyperandrogenism in the form of hirsutism. Patients were categorized into three groups, mild (FG score 8-15), moderate (FG score 15-25) and severe (FG score >25). Correlation between clinical (hirsutism) and biochemical hyperandrogenism (serum free testosterone levels) was assessed using Fisher exact test. Data was analyzed using SPSS version 25. Results: Biochemical hyperandrogenism in the form of raised free testosterone levels was present in 46 (32.9%) PCOS patients. Out of 12 patients having Ferriman Gallwey score >25, 10 (83.3%) had biochemical hyperandrogenism. Out of 70 patients having Ferriman Gallwey score 15-25, 22 (31.4%) had biochemical hyperandrogenism whereas out of 58 patients having Ferriman Gallwey score 8-15, only 14 (24.1%) patients had biochemical hyperandrogenism. Conclusion: Prevalence of biochemical hyperandrogenism in PCOS patients in our studied population was significantly low when compared to the population studied worldwide making it less reliable as diagnostic tool in this part of the world. Also there was significant positive correlation between free testosterone levels and degree of hirsutism which means that diagnostic accuracy of free testosterone in PCOS patients is considerably high in those having clinical hyperandrogenism.

International audience; Experimental Self-Mixing (SM) or optical feedback interferometric signals are usually affected by additive white Gaussian noise (AWGN) and impulsive noise. Depending on SM sensing setup , these noises can significantly reduce the signal to noise ratio (SNR) of SM signals which in turn affects the measurement performance of signal processing algorithms employed for metric information retrieval. In this paper, adaptive line enhancement (ALE) technique is proposed to remove AWGN and impulsive noise from SM signals. Specifically, a recursive least squares (RLS) based ALE algorithm has been designed and the results have been compared with established methods such as high-order digital low-pass filtering and discrete wavelet transform. The comparison indicates better precision in case of use of RLS-ALE even when significant variations occur in the operating optical feedback regime and remote target velocity as well as in presence of speckle. The proposed algorithm can also estimate the SNR of SM signals belonging to weak-, moderate-, and strong-optical feedback regime with SNR ranging from 0 dB to 40 dB, with a mean absolute error of 1.35 dB and a 1.09 dB precision. Statistical analysis of noise recovered from different experimental SM signals attests the Gaussian-and impulsive-nature of noise. Thus, the proposed method also enables a simple and reliable quantitative analysis and comparison of different laser diode based SM laser sensors operating under variable optical conditions.

Patients with inflammatory bowel disease (IBD) have numerous risk factors for low bone mineral density (BMD). We aimed to study the prevalence of low BMD in IBD and the factors associated with it. BMD was measured by radial quantitative ultrasound, and clinical and biochemical characteristics were compared in prospectively enrolled patients and healthy age and gender-matched controls. Chi-square test, t test for independent samples, analysis of variance (ANOVA), Mann–Whitney U test and Kruskal–Wallis H tests were used as appropriate for univariate analysis to compare the characteristics between patients with and without abnormal BMD. Binary logistic regression analysis was done to determine the factors associated with low BMD in IBD patients. One hundred and six patients (Crohn’s disease [CD] = 35, ulcerative colitis [UC] = 71) and 55 controls were included. Low BMD was equally prevalent in CD, UC and controls (42.9%, 36.6%, 36.4% respectively, p = 0.791). Serum calcium and vitamin D were significantly lower in IBD patients compared to controls (p

Objectives: To determine the association of low serum vitamin D levels with poor glycemic control and obesity in type 2 diabetic patients. Study Design: Descriptive Cross Sectional study. Setting: Sakina Institute of Diabetes and Endocrine Research Centre (SIDER), Shalamar Hospital Lahore. Period: 1st June to 31th august 2017. Material & Methods: After applying strict exclusion criteria, about 450 patients with known type II diabetes were enrolled in the present study and their HBA1C and fasting vitamin D levels were measured. Patients were divided into two groups, group 1 with poor glycemic control (HBA1C>8%) and group 2 with good glycemic control (HBA1C 23 were having suboptimal Vitamin D levels (p value

Introduction: Coronavirus has spread rapidly in Pakistan. These patients were kept at quarantine facilities on suspicion, even before RT-PCR was done. We were able to collect clinical, laboratory, and management features from them. Objective: To assess the features of Corona confirmed and unconfirmed patients, and compare them. It could help in deciding if confirmed and unconfirmed patients were correctly identified and managed appropriately. Material and Methods: Retrospective, Descriptive, Crossectional study between 8th April to 30th April 2020. Patient data was collected from different sites retrospectively, on a Performa. Clinical, Laboratory, and Management data as collected. It was analyzed on SPSS 23. All patients in quarantines and ICU were included, irrespective of their corona PCR status, if the treating physicians had a strong suspicion. Home quarantine and less than 15-year old patients were excluded. Results: Clinical features showed more preponderance for males and smokers. Chronic disease patients were also significantly involved. Fatigue, nasal congestion, runny nose, sickness, and vomiting were more common in confirmed patients. CURB 65 scores 3 and 4 were more in unconfirmed patients. CT involvement was more common in unconfirmed patients as was high white cells and neutrophils. More patients had mechanical ventilation in the unconfirmed group, and they also had more secondary infections and shock. Antibiotic use was more common in the confirmed group. Conclusion: Corona was more common in males and smokers. Though fever and cough were common, the presence of fatigue, runny nose, nasal congestion sickness, and vomiting discriminated confirmed patients. Antibiotics should be used irrespective of RT-PCR results, especially if CT showed an abnormality.

Cell communication via exosomes is capable of influencing cell fate in stress situations such as exposure to ionizing radiation. In vitro and in vivo studies have shown that exosomes might play a role in out-of-target radiation effects by carrying molecular signaling mediators of radiation damage, as well as opposite protective functions resulting in resistance to radiotherapy. However, a global understanding of exosomes and their radiation-induced regulation, especially within the context of an intact mammalian organism, has been lacking. In this in vivo study, we demonstrate that, compared to sham-irradiated (SI) mice, a distinct pattern of proteins and miRNAs is found packaged into circulating plasma exosomes after whole-body and partial-body irradiation (WBI and PBI) with 2 Gy X-rays. A high number of deregulated proteins (59% of WBI and 67% of PBI) was found in the exosomes of irradiated mice. In total, 57 and 13 miRNAs were deregulated in WBI and PBI groups, respectively, suggesting that the miRNA cargo is influenced by the tissue volume exposed to radiation. In addition, five miRNAs (miR-99b-3p, miR-200a-3p, miR-200a, miR-182-5p, miR-182) were commonly overexpressed in the exosomes from the WBI and PBI groups. In this study, particular emphasis was also given to the determination of the in vivo effect of exosome transfer by intracranial injection in the highly radiosensitive neonatal cerebellum at postnatal day 3. In accordance with a major overall anti-apoptotic function of the commonly deregulated miRNAs, here, we report that exosomes from the plasma of irradiated mice, especially in the case of WBI, prevent radiation-induced apoptosis, thus holding promise for exosome-based future therapeutic applications against radiation injury.

Fluoride (F) is a potent anti-cariogenic element, but only an appropriate dose is effective to have therapeutic action, else systemic toxicity may be observed. Additionally, two factors, amount of F and time of exposure, drive its action. Surprisingly, the susceptibility to toxic effects of F is genetically determined. The present study identified the effects of F on the liver proteome of mice susceptible (A/J) or resistant (129P3/J) to the effects of F. Weanling male A/J (n=6) and 129P3/J mice (n=6) were housed in pairs and assigned to three groups given low-F diet and drinking water containing 0, 15 or 50 ppm F for 7 weeks. Liver proteome profiles were examined using nano-LC-ESI-MS/MS. Protein function was classified by GO biological process (Cluego v2.0.7 + Clupedia v1.0.8). Difference in expression among the groups was determined using the PLGS software. In the control group (0 ppm F), most proteins with fold change were increased in A/J mice. Precisely the proteins related to energy flux and oxidative stress were quite significant in this context, suggesting the high susceptibility of these mice to the effects of F, since the exposure also induces oxidative stress. Treatment with the lower F concentration provoked more pronounced alterations in fold change in liver proteins in comparison to the treatment with the higher F concentration. Strikingly, most of the proteins with fold change upon following 15 ppm F treatment, were increased in the A/J mice compared with their 129P3/J counterparts, thus suggesting attempt of the former to fight against the toxic effects of F. With respect to 50 ppm F, most proteins with fold change were decreased in the A/J mice compared with their 129P3/J counterparts, especially proteins related to oxidative stress and protein folding, which might be related to the higher susceptibility of the A/J animals to the deleterious effects of F. Our findings can provide new insights into the molecular mechanisms underlying genetic susceptibility to fluorosis by indicating key protein players which need to be better addressed in future experimental studies. O Fluoreto (F) é um potente elemento anti-cariogênico, mas é somente efetivo terapeuticamente em uma dose apropriada. Por outro lado, doses acima das recomendadas levam a toxicidade sistêmica. Em adição, dois fatores decidem sua efetividade de ação: quantidade de F e tempo de exposição. A suscetibilidade aos efeitos tóxicos do F é determinada geneticamente. O presente estudo avaliou os efeitos do F no proteoma do fígado de camundongos suscetíveis (A/J) ou resistentes (129P3/J) aos efeitos do F. Camundongos machos desmamados A/J (n=6) e 129P3/J (n=6) foram alojados em pares e divididos em três grupos tratados com ração com baixo teor de F e água contendo 0, 15, ou 50 ppm de F por 7 semanas. Perfis proteômicos do fígado foram examinados usando nano-LC-ESI-MS/MS. A função de proteínas foi classificada pelo processamento biológico GO (Cluego v2.0.7 + Clupedia v1.0.8). A diferença de expressão entre os grupos foi determinada usando o software PLGS. No grupo controle (0 ppm F), a expressão da maioria das proteínas foi aumentada nos camundongos A/J e precisamente as proteínas relacionadas ao fluxo de energia e estresse oxidativo foram significativas neste contexto, sugerindo portanto, a alta sucetibilidade destes camundongos aos efeitos do F, já que a exposição também induz o estresse oxidativo. O tratamento com baixa concentração de F provocou alterações mais pronunciadas em proteínas do fígado comparado ao tratamento com alta concentração de F. Notadamente, a maioria das proteínas encontradas no fígado dos animais tratados com 15 ppm de F foi aumentada em camundongos A/J comparados aos camundongos 129P3/J, demonstrando portanto, uma tentativa dos A/J de neutralizar os efeitos tóxicos do F. Já nos animais tratados com 50 ppm de F, a maioria das proteínas foi diminuída nos camundongos comparados aos seus pares 129P3/J, especialmente proteínas relacionadas ao estresse oxidativo e enovelamento de proteínas, o que pode estar relacionado à alta suscetibilidade dos animais A/J aos efeitos deletérios do F. Nossos achados podem fornecer novos insights que podem contribuir para a interpretação os mecanismos moleculares relacionados à suscetibilidade genética à fluorose, indicando proteínas chaves que precisam ser melhor estudadas em estudos futuros.

Aim: To find out the frequency of thyroid hypo-functioning in β-thalassemia patients presenting at Endocrinology Outpatient Department of Jinnah Hospital, Lahore. Study design: Cross-sectional descriptive study Place and duration of study: Allama Iqbal Institute of Diabetes and Endocrinology, Jinnah Hospital Lahore from 5th June 2019 to 4th January 2020 Methodology: One hundred diagnosed cases of β-thalassemia of both genders with age range of 5-19 years were included. Random blood samples were taken to measure serum thyroid stimulating hormone (TSH) and free T4 levels by Enzyme Linked Immunosorbent Assay (ELISA). Results: Hypothyroidism was present in 32 (32%) patients. The frequency of hypothyroidism was same in 5-9 years versus 10-19 years age groups with no significant gender differences (p 0.434). The mean levels of ferritin were 5102±1134 ng/ml in thyroidhypo-functioning cases was 3687±1425 ng/ml in normal-functioning thyroid patients (P 0.001). Conclusion: Hypothyroidism is highly prevalent in β-thalassemia patients. Periodic check-ups are recommended for early diagnosis and interceptive treatment. Keywords: Thyroid; Hypothyroidism; Beta-thalassemia; Endocrinology

Background The standard treatment of displaced femoral neck fracture is arthroplasty. THA is reportedly superior to BHA in terms of hip pain, function and reoperation rate. On the other hand THA has a higher rate of dislocation. Total hip replacement with dual mobility cup increases the range of motion and reduces the chances of dislocation. The aim of this study is to compare the functional outcome, rate of dislocation, complications and mortality between BHA and THA with dual mobility cuff for the treatment of displaced neck of femur fracture. Patients and method This is a non-commercialized retrospective cohort study conducted at our tertiary care level 1 trauma centre. Patients of age group 60 years and above who underwent hip arthroplasty (BHA or THA with dual mobility implant) between 2015 and 2017 for displaced neck of femur fracture with a complete follow up for one year were included. Both groups were assessed for postoperative surgical complications including dislocation, fracture, surgical site infection, and medical complications, one-year mortality and functional outcome were analysed via Harris Hip Score (HHS) at the latest follow up. Results Overall 104 patients were included in the study out of which 77 patients underwent BHA while 27 underwent THA with dual mobility cup. Baseline characteristics were found to be similar in both groups. Mean pre-op HHS for bipolar group was found to be 71.01 while for THA with dual mobility cup group it was 73.52 with the difference being statistically insignificant (P = 0.12). Mean post-op HHS for bipolar group was noted to be 68.82 whereas for THA with dual mobility cup group it was 76.81. The difference was found to be statistically significant with a P-value of, Highlights • The standard treatment of displaced femoral neck fracture is arthroplasty. • Total Hip Arthroplasty is reportedly superior to Bipolar Hemiarthroplasty in terms of hip pain, function and reoperation rate. • Total Hip Arthroplasty has a higher rate of dislocation rate than Bipolar Hemiarthroplasty. • Total Hip Arthroplasty with Dual mobility cup increases the functional outcome and reduces the chances of dislocation.

Background Hip fractures usually occur in old aged patients with osteoporotic bone. Management of hip fractures in old aged patient is aimed to ambulate patient immediately and to restore the pre-operative ambulation. Proximal femur replacement is an effective treatment option in elderly patient with osteoporotic bones. It allow immediate weight bearing and early return to preoperative ambulatory status and minimizes the chances of systemic complication associated with prolong bed rest associated with internal fixation. This study is aimed to review the outcome of the patients whom underwent proximal femur replacement as primary treatment for the patient with comminuted intertrochanteric and sub trochanteric fracture. Patients and method This is a study conducted in our university hospital which is a tertiary-care level-1 trauma center. A retrospective analysis of 21 patients who underwent proximal femur replacement for comminuted intertrochanteric and sub trochanteric fracture, age more than 60 years during the period from April 2011 to March 2018 was conducted. Data collected included: age, gender, comorbidities, mechanism of injury, type of fracture, functional outcome (calculated via Harris Hip Score) and one year mortality. Results The mean age of the patients was 74.05(range 64–91) years, out of which 13 (61.8%) were female and 8 (38.0%) were male. The mean follow up was 32.6(8–91 months).Immediate post-operative ambulation status was full weight bearing (FWB) in 17 patients (80.9%) of the patients while three patients (19.0%) had non-weight bearing (NWB) due to associated co-morbidities. The mean preoperative Harris Hip score was 68.0, while the mean postoperative Harris Hip score was 66.5 at last follow up. Post operatively one patient (4.7%) developed pulmonary embolism, one patient developed dislocation. One patent (4.7%) died of sepsis from implant infection at 8 months after surgery Conclusion Primary Proximal femoral replacement in a viable option in old aged patients with poor bone quality who developed intertrochanteric and subtrochanteric fracture. According to our study, with mortality rate comparable to that of primary fixation, yet with the added advantage of immediate post op ambulation and reduced incidences of decubitus ulcers, atelectasis and DVT., Highlights • Management of hip fractures in old aged patient is aimed to ambulate patient immediately. • Proximal femur replacement is an effective treatment option in elderly patient with osteoporotic bones. • Proximal femur replacement allows immediate weight bearing and early return to preoperative ambulatory status.