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1. Can one long peritoneal dwell with icodextrin replace two short dwells with glucose?

Author

Joanna Stachowska-Pietka, Jacek Waniewski, Anna Olszowska, Elvia Garcia-Lopez, Junfei Yan, Qiang Yao, Zofia Wankowicz, and Bengt Lindholm

Subjects
chronic kidney disease, peritoneal dialysis, icodextrin, ultrafiltration, sodium removal, glucose absorption, Physiology, QP1-981
Abstract

BackgroundDue to the slower dissipation of the osmotic gradient, icodextrin-based solutions, compared to glucose-based solutions, can improve water removal. We investigated scenarios where one icodextrin-based long dwell (Extraneal) replaced two glucose-based exchanges.MethodsThe three-pore model with icodextrin hydrolysis was used for numerical simulations of a single exchange to investigate the impact of different peritoneal dialysis schedules on fluid and solute removal in patients with different peritoneal solute transfer rates (PSTRs). We evaluated water removal (ultrafiltration, UF), absorbed mass of glucose (AbsGluc) and carbohydrates (AbsCHO, for glucose and glucose polymers), ultrafiltration efficiency (UFE = UF/AbsCHO) per exchange, and specified dwell time, and removed solute mass for sodium (ReNa), urea (ReU), and creatinine (ReCr) for a single peritoneal exchange with 7.5% icodextrin (Extraneal®) and glucose-based solutions (1.36% and 2.27%) and various dwell durations in patients with fast and average PSTRs.ResultsIntroducing 7.5% icodextrin for the long dwell to replace one of three or four glucose-based exchanges per day leads to increased fluid and solute removal and higher UF efficiency for studied transport groups. Replacing two glucose-based exchanges with one icodextrin exchange provides higher or similar water removal and higher daily sodium removal but slightly lower daily removal of urea and creatinine, irrespective of the transport type present in the case of reference prescription with three and four daily exchanges.ConclusionOne 7.5% icodextrin can replace two glucose solutions. Unlike glucose-based solutions, it resulted only in minor differences between PSTR groups in terms of water and solute removal with UFE remaining stable up to 16 h.

Published
2024
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2. Modelling of icodextrin hydrolysis and kinetics during peritoneal dialysis

Author

Joanna Stachowska-Pietka, Jacek Waniewski, Anna Olszowska, Elvia Garcia-Lopez, Zofia Wankowicz, and Bengt Lindholm

Subjects
Medicine, Science
Abstract

Abstract In peritoneal dialysis, ultrafiltration is achieved by adding an osmotic agent into the dialysis fluid. During an exchange with icodextrin-based solution, polysaccharide chains are degraded by α-amylase activity in dialysate, influencing its osmotic properties. We modelled water and solute removal taking into account degradation by α-amylase and absorption of icodextrin from the peritoneal cavity. Data from 16 h dwells with icodextrin-based solution in 11 patients (3 icodextrin-exposed, 8 icodextrin-naïve at the start of the study) on dialysate volume, dialysate concentrations of glucose, urea, creatinine and α-amylase, and dialysate and blood concentrations of seven molecular weight fractions of icodextrin were analysed. The three-pore model was extended to describe hydrolysis of icodextrin by α-amylase. The extended model accurately predicted kinetics of ultrafiltration, small solutes and icodextrin fractions in dialysate, indicating differences in degradation kinetics between icodextrin-naïve and icodextrin-exposed patients. In addition, the model provided information on the patterns of icodextrin degradation caused by α-amylase. Modelling of icodextrin kinetics using an extended three-pore model that takes into account absorption of icodextrin and changes in α-amylase activity in the dialysate provided accurate description of peritoneal transport and information on patterns of icodextrin hydrolysis during long icodextrin dwells.

Published
2023
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3. PERITONEAL DIALYSIS 1

Author

Nada Dimkovic, Wei Mei Lim, Mercedes Moreiras-Plaza, Carmen A. Vlahu, Seok Hui Kang, Shadi Hassan, Kamal Hassan, Yuta Kogure, Magnus Braide, Elbis Ahbap, Isabel Silva, Şeref Yüksel, Yon-Su Kim, Mauro Pietribiasi, Sibel Gokcay Bek, Deirisa Lopes Barreto, Rosa M. Agostinelli, Saimir Seferi, Cuneyt Akgol, Flora Correia, Ploumis Passadakis, José Portolés, Taisuke Shimizu, Martin Wilkie, Gülay Ulusal Okyay, Raquel Blanco-García, Manuel Pestana, Mauro Marani, Daniel Baczyński, Young-Il Jo, Jan Poleszczuk, Alexander Shturman, Jae Hyun Chang, Abdulkadir Unsal, G Caparrós, André Luis Balbi, Theodora Gioka, G. Lenzora, María José Fernández-Reyes, Vassilis Vargemezis, Ahmet Ahsen, Carla Santos-Araújo, Ekrem Kara, Gloria del Peso, Ibrahim Saeed, Tuncay Sahutoglu, Adnan Batman, Grazia Maria Virzì, Darío Janeiro, Mustafa Sevinc, Merita Rroji, Ha-Young Na, Marijke de Graaff, S. Scofferi, Efthimia Mourvati, Nestor Thereska, Tetsuya Mitarai, Ines Castellano, Stefano Santarelli, Triantafillia Bounta, James Fotheringham, Jong Won Park, Irina Rubinchik, Tomonari Ogawa, Jacek Waniewski, Raweewan Witoon, Jose Barata, Matthias Zeiler, Rafael Selgas, Hyun Hee Lee, Fadi Hassan, Takatsugu Iwashita, Abdullah K Al-Hwiesh, Salih I·Nal, Liliana Simões Silva, Shaul Atar, Vanessa Banin, Tatjana Lazarevic, Touta Kiba, Massimo de Cal, Erkan Dervisoglu, Elias Thodis, Kyung Yoon Chang, Ricardo Vizinho, Nam Ho Kim, Antosiewicz S, Hajime Hasegawa, Wan Shaariah Mohd Yusuf, Marjorie Foo, Denise E. Sampimon, Ljubica Djukanovic, Marios Theodoridis, Lily Mushahar, Paolo Ancarani, Patricia Martinez Miguel, Francisco Fernández-Fleming, Yong Kyun Kim, Lorena Ferrando, Selman Ünverdi, Murat Duranay, Rui Poínhos, Marina Di Luca, Raymond T. Krediet, Pasqual Barretti, Jelena Marinkovic, Pelagia Kriki, Shinpei Okazaki, Athanasios Roumeliotis, Young Ok Kim, Maria João Sousa, Akihiko Matsuda, Laura Beato-Coo, D. Parodi, Necmi Eren, Shin Wook Kang, Tania Monteburini, Sudhaharan Sivathasan, Atila Altuntaş, Dirk G. Struijk, Sung Jin Moon, Jun Young Do, Zhenli Yu, Yousuke Tayama, Carlo Crepaldi, Mohamed Nasreldin, Rita Marinelli, O. Terrile, Konstadina Griva, Isabel Martin-Baez, Yong-Lim Kim, Kyung Woo Yoon, Michael J. Campbell, Young Baek Kim, Wookyung Chung, Ana Rita Martins, Dunia Hassan, Sabrina Milan Manani, Majster Zdenka, Genc Burazeri, Su-Hyun Kim, Ilaria Tantillo, Alessandra Brocca, Mayra Ortega, Fatma Ceyla Eraldemir, Jacqueline Costa Teixeira Caramori, Tamer Sakaci, Veysel Kidir, Hans Vink, Maite Rivera, Claudio Ronco, Ho Chul Song, Ji Yong Jung, Han Ro, Memnune Sena Ulu, Patrícia Branco, Kyu Hyang Cho, Steva Pljesa, Hyung Wook Kim, Margarida Sarmento-Dias, Chul Woo Yang, Paula López, Taner Basturk, Daniela Ponce, Yener Koc, Mehmet Tugrul Sezer, Minoru Hatano, Caterina Riello, Maria Augusta Gaspar, Zofia Wankowicz, Tricya Bueloni, and Ana M Tato

Subjects
03 medical and health sciences, Transplantation, medicine.medical_specialty, 0302 clinical medicine, Nephrology, business.industry, medicine.medical_treatment, 030232 urology & nephrology, medicine, Urology, 030204 cardiovascular system & hematology, business, Peritoneal dialysis
Published
2014

4. Peritoneal transport in peritoneal dialysis patients using glucose-based and amino acid-based solutions

Author

Anna, Olszowska, Jacek, Waniewski, Andrzej, Werynski, Björn, Anderstam, Bengt, Lindholm, and Zofia, Wankowicz

Subjects
Adult, Male, Kinetics, Glucose, Peritoneal Dialysis, Continuous Ambulatory, Dialysis Solutions, Biological Transport, Active, Humans, Female, Amino Acids, Middle Aged, Peritoneum, Aged
Abstract

To evaluate peritoneal transport of fluid and solutes in continuous ambulatory peritoneal dialysis (CAPD) patients using amino acid (AA)-based versus glucose-based dialysis solutions.Using iodine-labeled human serum albumin ((125)I-HSA) as intraperitoneal volume marker, peritoneal transport was investigated in a group of 20 clinically stable patients (11 females and 9 men, age 53 +/- 15 years) on CAPD for 15 - 101 months. Two paired 4-hour dwells, one with 1.36% glucose and one with 1.1% AA dialysis solution, were performed in each patient. Intraperitoneal dialysate volume, fluid absorption rate, and diffusive mass transport coefficients (K(BD)) and sieving coefficients (S) for glucose, creatinine, urea, potassium, and total protein were estimated for each dwell study. Dwell studies with AA solution were used to estimate K(BD) values for individual AAs.Intraperitoneal dialysate volume was higher for AA solution in comparison with glucose solution due to the higher osmolality of the AA solution. No statistically significant difference was found for K(BD) or S for creatinine, urea, potassium, or total protein in the dwell studies with either solution, whereas K(BD) for glucose was higher with AA than with glucose solution. Mean values of K(BD) of AA were similar but with high standard deviation, reflecting inter-individual variations in peritoneal transport rate.Our results indicate that the AA peritoneal transport rate is strongly dependent on transport characteristics of the individual peritoneal membrane.

Published
2007

5. Peritoneal dialysis - 1

Author

Fatma Eroglu, Claudio Pozzi, Hyunwook Kim, Claudio Ronco, Benjamin Zeier, Xueqing Yu, Dirk G. Struijk, Javier Ocaña, Roman Stankiewicz, Marilena Cara, Taner Camsari, Jun Wada, Susan Yung, Hung Shih-Yuan, Fu-Chang Hu, Michał Nowicki, Ni Gao, Denise E. Sampimon, Deirisa Lopes Barreto, Zulfikar Yilmaz, Martin Zeier, Johan V. Povlsen, Daniele Ciurlino, Zofia Wankowicz, Yu-Yin Tsai, Rungmei S. K. Marak, Renzo Scanziani, Chang Ming-Yu, Iraj Najafi, Xiao Yang, Kazumichi Matsushita, Show-Mei Nian, Tak Mao Chan, Chunyan Yi, Yung-Ming Chen, Manel Vera, Eduard Garcia, Cheng-Hsu Chen, Laura Buzzi, Jens Dam Jensen, Petar Kes, Hung-Chun Chen, Almudena Ortigosa, Zeljka Mustapic, Wing-Fai Pang, Paula López-Sánchez, Christian Thiede, Carlo Crepaldi, Vedat Schwenger, Marie-Luise Gross, Giovambattista Virga, Qingyu Kong, Aiping Gu, Jenq-Wen Huang, Manuel Corral, Gao Dan, Ching-Yuang Lin, Liang Xian-hui, Wim Van Biesen, Isao Araki, Tetsu Miyamoto, Ivana Jurić, Roberto Russo, Xiuqing Dong, Francisco Coronel, Erjola Likaj, Ramazan Cetinkaya, Wieslawa Lysiak-Szydlowska, Chi-Chih Hung, Uta Oelschlaegel, Cheuk-Chun Szeto, Shigeru Akagi, Yuji Takatori, Ulrike Haug, Chih-Kang Chiang, Julia Kerschbaum, Veysi Akpolat, Per Ivarsen, Qiang Yao, Elena Alberghini, Lee Yi-Jer, Claudio Musetti, Bengt Lindholm, Mei-Chuan Kuo, Paweł Stróżecki, Michael A. Rudnicki, Teresa Grzelak, Aiwu Lin, Catherine Chen, Lars P. Kihm, Young Chul Yoon, Masahito Tamura, Qing Zhang, Mihaela Petti, A. Lawerence, Dong Hyung Lee, Shih-Tin Huang, Jun Wu, Xinghui Lin, Beom Seok Kim, Luciana Bonfante, Elżbieta Marcinkowska, Mariapia Rodighiero, Marijke de Graaff, Silvia Furiani, June Fabian, Tatsuya Miyamoto, Elena Corchete, Myftar Barbullushi, Manabu Kamiyama, Anna Stefańska, Sandra Müller-Krebs, Shin Wook Kang, Hasan Kayabasi, Mercedes Velo, Enzo Corghi, Kai-Ming Chow, Zbigniew Heleniak, Nikolina Bašić-Jukić, Raymond T. Krediet, Constanze Meye, Min-Ju Wu, Zhao Zhanzheng, Ryota Serino, Pierluigi di Loreto, Nicole Ladeira, Monika Lichodziejewska-Niemierko, Nader Nouri-Majalan, Hoshang Sanadgol, Gülgün Oktay, Raj Kumar Sharma, Yoshiaki Doi, Beata Szary, Anupma Kaul, Katarzyna Osiewala, Ivano Baragetti, Shang-Jyh Hwang, Paul König, Kuo-Hsiung Shu, Kuan-Yu Hung, M. Emin Yilmaz, Francisco Maduell, Haeng Soon Jeong, Yumi Furuno, Maurizio Nordio, Andrea Wagner, Hameed Anijeet, Jacek Rysz, Hye Ran Kim, Xiaoyan Li, Philip Kam-Tao Li, Ilaria Serra, Zhaohui Ni, Ya-Wen Chuang, Ali Kemal Kadiroglu, Marta Arias, Vincenzo La Milia, Yucheng Yan, José Portolés, Jacek Manitius, Liu Zhangsuo, Sagren Naidoo, Snjezana Glavas-Boras, Aliyu Abdu, Bolesław Rutkowski, Chi-Hung Cheng, Juan M. López-Gómez, Chia-Te Liao, Kay Herbrig, Joanna Stachowska-Pietka, Mieko MIyazaki, Xin Wang, Peter Gross, Tun-Jun Tsai, Weiying Chen, Jacek Waniewski, Mario R. Korte, Efsun Kolatan, Dorota Bielińska − Ogrodnik, Keiichi Takiue, Tatsuya Shibata, Eun Young Kim, Isabel Devolder, Ho Li-Chun, Zahide Cavdar, Makoto Hiramatsu, Si Hyun Kim, Mayte Ribera, Marcia R. Gómez, Rafał Donderski, Sylwia Małgorzewicz, Shirin Malgas, Dede Sit, Dariusz Nowak, Hamidullah Uyanik, Tobias Drescher, Ming-Ju Wu, Annick Verleysen, Robert A. Stolarek, Junko Inoue, Aggrey Mweemba, Aleix Cases, Grzegorz Zelichowski, Krystyna Czyżewska, Ho Yung Lee, Nagahiro Sato, Yutaka Otsuji, Jeong Hwan Shin, Shoichiro Kojo, Jiaqi Qian, Yang Wook Kim, Jens Passauer, Johann Hausdorfer, Osman Yilmaz, Hirofumi Makino, Tae Ik Chang, Ahmet Duraku, Tzu-Hui Chen, Jianxiong Lin, Hitoshi Sugiyama, Magdalena Grajewska, J.M. Campsitol, Yeong Hoon Kim, Jung Tak Park, Raymond Vanholder, Chi-Bon Leung, Chen-Yen Kuo, Anniek Vlijm, Li Yan, Hsin-Hui Wang, Takashi Yamagishi, Jae Hyun Chang, Jin-Bor Chen, Antonio Alcaraz, Patricia de Sequera, Jolanta Fijalkowska, Wang Hsi-Hao, Anna Olszowska, Rammohan Bhat, Mizuya Fukasawa, Graham Paget, Jocelyn T Naicker, Saimir Seferi, Silvio Bertoli, Wei Fang, Gert Mayer, Ling Ye, Mustafa Keles, Su-Chu Lee, Masashi Suzuki, Kwan-Dun Wu, Saraladevi Naicker, Denise Sampimon, Shang-Chih Liao, Kyu Hun Choi, Bonnie Ching-Ha Kwan, Sarasadat Moghadasimousavi, Giorgio Vescovo, Adrianna Pedzik, Muhammad Imran, Weiming Zhang, Narutoshi Kabashima, Funda Saglam, Tae Hyun Yoo, Martin Bornhäuser, Tung-Min Yu, Ryoko Baba, Nestor Thereska, Sun Young Park, Masami Bessho, Sulen Sarioglu, Hamit Acemoglu, Hiroshi Morinaga, Kazushi Nakao, Abdullah Uyanik, Andrzej Werynski, Masayuki Takedda, Dong Ki Kim, Jeong Nyeo Lee, Bang-Gee Hsu, Bergadá E, Shouji Kudo, and Néstor Fontseré

Subjects
Transplantation, medicine.medical_specialty, Nephrology, business.industry, medicine.medical_treatment, medicine, Urology, business, Peritoneal dialysis
Published
2009

6. Long Peritoneal Dialysis Dwells With Icodextrin: Kinetics of Transperitoneal Fluid and Polyglucose Transport

Author

Anna Olszowska, Jacek Waniewski, Joanna Stachowska-Pietka, Elvia Garcia-Lopez, Bengt Lindholm, and Zofia Wańkowicz

Subjects
end-stage kidney disease, peritoneal dialysis, ultrafiltration, osmotic agent, polyglucose metabolites, amylase, Physiology, QP1-981
Abstract

Background and objective: During peritoneal dialysis (PD), the period of effective net peritoneal ultrafiltration during long dwells can be extended by using the colloidal osmotic agent icodextrin but there are few detailed studies on ultrafiltration with icodextrin solution exceeding 12 h. We analyzed kinetics of peritoneal ultrafiltration in relation to icodextrin and its metabolites for 16-h dwells with icodextrin.Design, setting, participants, and measurements: In 20 clinically stable patients (mean age 54 years; 8 women; mean preceding time on PD 26 months), intraperitoneal dialysate volume (VD) was estimated from dilution of 125I-human serum albumin during 16-h dwell studies with icodextrin 7.5% solution. Sodium was measured in dialysate and plasma. In 11 patients, fractional absorption of icodextrin from dialysate, dialysate, and plasma amylase and high and low (Mw

Published
2019
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