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1. Myocardial T1 and T2 Mapping by Magnetic Resonance in Patients With Immune Checkpoint Inhibitor-Associated Myocarditis.

Author

Thavendiranathan, Paaladinesh, Zhang, Lili, Zafar, Amna, Drobni, Zsofia D, Mahmood, Syed S, Cabral, Marcella, Awadalla, Magid, Nohria, Anju, Zlotoff, Daniel A, Thuny, Franck, Heinzerling, Lucie M, Barac, Ana, Sullivan, Ryan J, Chen, Carol L, Gupta, Dipti, Kirchberger, Michael C, Hartmann, Sarah E, Weinsaft, Jonathan W, Gilman, Hannah K, Rizvi, Muhammad A, Kovacina, Bojan, Michel, Caroline, Sahni, Gagan, González-Mansilla, Ana, Calles, Antonio, Fernández-Avilés, Francisco, Mahmoudi, Michael, Reynolds, Kerry L, Ganatra, Sarju, Gavira, Juan José, González, Nahikari Salterain, García de Yébenes Castro, Manuel, Kwong, Raymond Y, Jerosch-Herold, Michael, Coelho-Filho, Otavio R, Afilalo, Jonathan, Zataraín-Nicolás, Eduardo, Baksi, A John, Wintersperger, Bernd J, Calvillo-Arguelles, Oscar, Ederhy, Stephane, Yang, Eric H, Lyon, Alexander R, Fradley, Michael G, and Neilan, Tomas G

Abstract

Myocarditis is a potentially fatal complication of immune checkpoint inhibitor (ICI) therapy. Data on the utility of cardiovascular magnetic resonance (CMR) T1 and T2 mapping in ICI myocarditis are limited.This study sought to assess the value of CMR T1 and T2 mapping in patients with ICI myocarditis.In this retrospective study from an international registry of patients with ICI myocarditis, clinical and CMR findings (including T1 and T2 maps) were collected. Abnormal T1 and T2 were defined as 2 SD above site (vendor/field strength specific) reference values and a z-score was calculated for each patient. Major adverse cardiovascular events (MACE) were a composite of cardiovascular death, cardiogenic shock, cardiac arrest, and complete heart block.Of 136 patients with ICI myocarditis with a CMR, 86 (63%) had T1 maps and 79 (58%) also had T2 maps. Among the 86 patients (66.3 ± 13.1 years of age), 36 (41.9%) had a left ventricular ejection fraction

Published
2021

2. Electrocardiographic features of immune checkpoint inhibitor associated myocarditis.

Author

Zlotoff, Daniel A, Hassan, Malek Z O, Zafar, Amna, Alvi, Raza M, Awadalla, Magid, Mahmood, Syed S, Zhang, Lili, Chen, Carol L, Ederhy, Stephane, Barac, Ana, Banerji, Dahlia, Jones-O'Connor, Maeve, Murphy, Sean P, Armanious, Merna, Forrestal, Brian J, Kirchberger, Michael C, Coelho-Filho, Otavio R, Rizvi, Muhammad A, Sahni, Gagan, Mandawat, Anant, Tocchetti, Carlo G, Hartmann, Sarah, Gilman, Hannah K, Zatarain-Nicolás, Eduardo, Mahmoudi, Michael, Gupta, Dipti, Sullivan, Ryan, Ganatra, Sarju, Yang, Eric H, Heinzerling, Lucie M, Thuny, Franck, Zubiri, Leyre, Reynolds, Kerry L, Cohen, Justine V, Lyon, Alexander R, Groarke, John, Thavendiranathan, Paaladinesh, Nohria, Anju, Fradley, Michael G, and Neilan, Tomas G

Abstract

Myocarditis is a highly morbid complication of immune checkpoint inhibitor (ICI) use that remains inadequately characterized. The QRS duration and the QTc interval are standardized electrocardiographic measures that are prolonged in other cardiac conditions; however, there are no data on their utility in ICI myocarditis.From an international registry, ECG parameters were compared between 140 myocarditis cases and 179 controls across multiple time points (pre-ICI, on ICI prior to myocarditis, and at the time of myocarditis). The association between ECG values and major adverse cardiac events (MACE) was also tested.Both the QRS duration and QTc interval were similar between cases and controls prior to myocarditis. When compared with controls on an ICI (93±19 ms) or to baseline prior to myocarditis (97±19 ms), the QRS duration prolonged with myocarditis (110±22 ms, p

Published
2021

3. Major Adverse Cardiovascular Events and the Timing and Dose of Corticosteroids in Immune Checkpoint Inhibitor�Associated Myocarditis

Author

Zhang, Lili, Zlotoff, Daniel A, Awadalla, Magid, Mahmood, Syed S, Nohria, Anju, Hassan, Malek Z.O., Thuny, Franck, Zubiri, Leyre, Chen, Carol L, Sullivan, Ryan J, Alvi, Raza M, Rokicki, Adam, Murphy, Sean P, Jones-O’Connor, Maeve, Heinzerling, Lucie M, Barac, Ana, Forrestal, Brian J, Yang, Eric H, Gupta, Dipti, Kirchberger, Michael C, Shah, Sachin P, Rizvi, Muhammad A, Sahni, Gagan, Mandawat, Anant, Mahmoudi, Michael, Ganatra, Sarju, Ederhy, Stephane, Zatarain-Nicolas, Eduardo, Groarke, John D, Tocchetti, Carlo G, Lyon, Alexander R, Thavendiranathan, Paaladinesh, Cohen, Justine V, Reynolds, Kerry L, Fradley, Michael G, and Neilan, Tomas G

Published
2020

4. Cardiovascular magnetic resonance in immune checkpoint inhibitor-associated myocarditis.

Author

Zhang, Lili, Awadalla, Magid, Mahmood, Syed S, Nohria, Anju, Hassan, Malek Z O, Thuny, Franck, Zlotoff, Daniel A, Murphy, Sean P, Stone, James R, Golden, Doll Lauren Alexandra, Alvi, Raza M, Rokicki, Adam, Jones-O'Connor, Maeve, Cohen, Justine V, Heinzerling, Lucie M, Mulligan, Connor, Armanious, Merna, Barac, Ana, Forrestal, Brian J, Sullivan, Ryan J, Kwong, Raymond Y, Yang, Eric H, Damrongwatanasuk, Rongras, Chen, Carol L, Gupta, Dipti, Kirchberger, Michael C, Moslehi, Javid J, Coelho-Filho, Otavio R, Ganatra, Sarju, Rizvi, Muhammad A, Sahni, Gagan, Tocchetti, Carlo G, Mercurio, Valentina, Mahmoudi, Michael, Lawrence, Donald P, Reynolds, Kerry L, Weinsaft, Jonathan W, Baksi, A John, Ederhy, Stephane, Groarke, John D, Lyon, Alexander R, Fradley, Michael G, Thavendiranathan, Paaladinesh, and Neilan, Tomas G

Abstract

Myocarditis is a potentially fatal complication of immune checkpoint inhibitors (ICI). Sparse data exist on the use of cardiovascular magnetic resonance (CMR) in ICI-associated myocarditis. In this study, the CMR characteristics and the association between CMR features and cardiovascular events among patients with ICI-associated myocarditis are presented.From an international registry of patients with ICI-associated myocarditis, clinical, CMR, and histopathological findings were collected. Major adverse cardiovascular events (MACE) were a composite of cardiovascular death, cardiogenic shock, cardiac arrest, and complete heart block. In 103 patients diagnosed with ICI-associated myocarditis who had a CMR, the mean left ventricular ejection fraction (LVEF) was 50%, and 61% of patients had an LVEF ≥50%. Late gadolinium enhancement (LGE) was present in 48% overall, 55% of the reduced EF, and 43% of the preserved EF cohort. Elevated T2-weighted short tau inversion recovery (STIR) was present in 28% overall, 30% of the reduced EF, and 26% of the preserved EF cohort. The presence of LGE increased from 21.6%, when CMR was performed within 4 days of admission to 72.0% when CMR was performed on Day 4 of admission or later. Fifty-six patients had cardiac pathology. Late gadolinium enhancement was present in 35% of patients with pathological fibrosis and elevated T2-weighted STIR signal was present in 26% with a lymphocytic infiltration. Forty-one patients (40%) had MACE over a follow-up time of 5 months. The presence of LGE, LGE pattern, or elevated T2-weighted STIR were not associated with MACE.These data suggest caution in reliance on LGE or a qualitative T2-STIR-only approach for the exclusion of ICI-associated myocarditis.

Published
2020

5. Serial Measurement of Global Longitudinal Strain Among Women With Breast Cancer Treated With Proton Radiation Therapy: A Prospective Trial for 70 Patients

Author

Hassan, Malek Z.O., Awadalla, Magid, Tan, Timothy C., Scherrer-Crosbie, Marielle, Bakar, Rula Bany, Drobni, Zsofia D., Zarif, Azmaeen, Gilman, Hannah K, Supraja, Sama, Nikolaidou, Sofia, Zhang, Lili, Zlotoff, Daniel A., Hickey, Shea B., Patel, Sagar A., Januzzi, James L., Keane, Florence, Passeri, Jonathon J., Neilan, Tomas G., MacDonald, Shannon M., and Jimenez, Rachel B.

Published
2023
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7. Pre-Existing Autoimmune Disease Increases the Risk of Cardiovascular and Noncardiovascular Events After Immunotherapy

Author

Lee, Charlotte, Drobni, Zsofia D., Zafar, Amna, Gongora, Carlos A., Zlotoff, Daniel A., Alvi, Raza M., Taron, Jana, Rambarat, Paula K., Schoenfeld, Sara, Mosarla, Ramya C., Raghu, Vineet K., Hartmann, Sarah E., Gilman, Hannah K., Murphy, Sean P., Sullivan, Ryan J., Faje, Alexander, Hoffmann, Udo, Zhang, Lili, Mayrhofer, Thomas, Reynolds, Kerry L., and Neilan, Tomas G.

Published
2022
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8. Global Circumferential and Radial Strain Among Patients With Immune Checkpoint Inhibitor Myocarditis

Author

Quinaglia, Thiago, Gongora, Carlos, Awadalla, Magid, Hassan, Malek Z.O., Zafar, Amna, Drobni, Zsofia D., Mahmood, Syed S., Zhang, Lili, Coelho-Filho, Otavio R., Suero-Abreu, Giselle A., Rizvi, Muhammad A., Sahni, Gagan, Mandawat, Anant, Zatarain-Nicolás, Eduardo, Mahmoudi, Michael, Sullivan, Ryan, Ganatra, Sarju, Heinzerling, Lucie M., Thuny, Franck, Ederhy, Stephane, Gilman, Hannah K., Sama, Supraja, Nikolaidou, Sofia, Mansilla, Ana González, Calles, Antonio, Cabral, Marcella, Fernández-Avilés, Francisco, Gavira, Juan José, González, Nahikari Salterain, García de Yébenes Castro, Manuel, Barac, Ana, Afilalo, Jonathan, Zlotoff, Daniel A., Zubiri, Leyre, Reynolds, Kerry L., Devereux, Richard, Hung, Judy, Picard, Michael H., Yang, Eric H., Gupta, Dipti, Michel, Caroline, Lyon, Alexander R., Chen, Carol L., Nohria, Anju, Fradley, Michael G., Thavendiranathan, Paaladinesh, and Neilan, Tomas G.

Published
2022
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9. Hemodynamic and Clinical Performance of Hearts Donated After Circulatory Death

Author

D’Alessandro, David A., Wolfe, Stanley B., Osho, Asishana A., Drezek, Kamila, Prario, Monica N., Rabi, S. Alireza, Michel, Eriberto, Tsao, Lana, Coglianese, Erin, Doucette, Meaghan, Zlotoff, Daniel A., Newton-Cheh, Christopher, Thomas, Sunu S., Ton, Van-Khue, Sutaria, Nilay, Schoenike, Mark W., Christ, Anastasia M., Paneitz, Dane C., Villavicencio, Mauricio, Madsen, Joren C., Pierson, Richard, and Lewis, Gregory D.

Published
2022
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10. Activin type II receptor signaling in cardiac aging and heart failure

Author

Roh, Jason D, Hobson, Ryan, Chaudhari, Vinita, Quintero, Pablo, Yeri, Ashish, Benson, Mark, Xiao, Chunyang, Zlotoff, Daniel, Bezzerides, Vassilios, Houstis, Nicholas, Platt, Colin, Damilano, Federico, Lindman, Brian R, Elmariah, Sammy, Biersmith, Michael, Lee, Se-Jin, Seidman, Christine E, Seidman, Jonathan G, Gerszten, Robert E, Lach-Trifilieff, Estelle, Glass, David J, and Rosenzweig, Anthony

Subjects
Aging, Heart Disease, Cardiovascular, 2.1 Biological and endogenous factors, Aetiology, Activin Receptors, Type II, Activins, Adult, Aged, Aged, 80 and over, Animals, Constriction, Pathologic, Disease Models, Animal, Follistatin-Related Proteins, Frailty, Heart Failure, Heart Ventricles, Humans, Ligands, Male, Mice, Inbred C57BL, Middle Aged, Myocardium, Myocytes, Cardiac, Pressure, Proteasome Endopeptidase Complex, Proteolysis, Rats, Sarcoplasmic Reticulum Calcium-Transporting ATPases, Severity of Illness Index, Signal Transduction, Systole, Biological Sciences, Medical and Health Sciences
Abstract

Activin type II receptor (ActRII) ligands have been implicated in muscle wasting in aging and disease. However, the role of these ligands and ActRII signaling in the heart remains unclear. Here, we investigated this catabolic pathway in human aging and heart failure (HF) using circulating follistatin-like 3 (FSTL3) as a potential indicator of systemic ActRII activity. FSTL3 is a downstream regulator of ActRII signaling, whose expression is up-regulated by the major ActRII ligands, activin A, circulating growth differentiation factor-8 (GDF8), and GDF11. In humans, we found that circulating FSTL3 increased with aging, frailty, and HF severity, correlating with an increase in circulating activins. In mice, increasing circulating activin A increased cardiac ActRII signaling and FSTL3 expression, as well as impaired cardiac function. Conversely, ActRII blockade with either clinical-stage inhibitors or genetic ablation reduced cardiac ActRII signaling while restoring or preserving cardiac function in multiple models of HF induced by aging, sarcomere mutation, or pressure overload. Using unbiased RNA sequencing, we show that activin A, GDF8, and GDF11 all induce a similar pathologic profile associated with up-regulation of the proteasome pathway in mammalian cardiomyocytes. The E3 ubiquitin ligase, Smurf1, was identified as a key downstream effector of activin-mediated ActRII signaling, which increased proteasome-dependent degradation of sarcoplasmic reticulum Ca2+ ATPase (SERCA2a), a critical determinant of cardiomyocyte function. Together, our findings suggest that increased activin/ActRII signaling links aging and HF pathobiology and that targeted inhibition of this catabolic pathway holds promise as a therapeutic strategy for multiple forms of HF.

Published
2019

11. Sodium-Glucose Co-Transporter-2 Inhibitors and Cardiac Outcomes Among Patients Treated With Anthracyclines

Author

Gongora, Carlos A., Drobni, Zsofia D., Quinaglia Araujo Costa Silva, Thiago, Zafar, Amna, Gong, Jingyi, Zlotoff, Daniel A., Gilman, Hannah K., Hartmann, Sarah E., Sama, Supraja, Nikolaidou, Sofia, Suero-Abreu, Giselle Alexandra, Jacobsen, Eric, Abramson, Jeremy S., Hochberg, Ephraim, Barnes, Jeffrey, Armand, Philippe, Thavendiranathan, Paaladinesh, Nohria, Anju, and Neilan, Tomas G.

Published
2022
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13. Abstract 11983: Associations Between Circulating Proteins and Intracardiac Immune Populations in Immune Checkpoint Inhibitor-Associated Myocarditis

Author

Zlotoff, Daniel, Blum, Steven, Ramesh, Swetha, Kernin, Isabela, Smith, Neal, Sen, Pritha, Zubiri, Leyre, Tirard, Alice, Nasrallah, Mazen, Tantivit, Jessica, Manakongtreecheep, Kasidet, Arnold, Benjamin, Chan, PuiYee, Barth, Jaimie, Juric, Dejan, Sullivan, Ryan, Boland, Genevieve, Mino-Kenudson, Mari, Stone, James R, Thomas, Molly F, Caplin, Joshua, Reynolds, Kerry, Neilan, Tomas G, and Villani, Alexandra-Chloe

Published
2022
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14. Cardiovascular Events Among Adults Treated With Chimeric Antigen Receptor T-Cells (CAR-T)

Author

Alvi, Raza M., Frigault, Matthew J., Fradley, Michael G., Jain, Michael D., Mahmood, Syed S., Awadalla, Magid, Lee, Dae Hyun, Zlotoff, Daniel A., Zhang, Lili, Drobni, Zsofia D., Hassan, Malek Z.O., Bassily, Emmanuel, Rhea, Isaac, Ismail-Khan, Roohi, Mulligan, Connor P., Banerji, Dahlia, Lazaryan, Aleksandr, Shah, Bijal D., Rokicki, Adam, Raje, Noopur, Chavez, Julio C., Abramson, Jeremy, Locke, Frederick L., and Neilan, Tomas G.

Published
2019
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17. Immune Responses in Checkpoint Myocarditis Across Heart, Blood, and Tumor

Author

Blum, Steven M., primary, Zlotoff, Daniel A., additional, Smith, Neal P., additional, Kernin, Isabela J., additional, Ramesh, Swetha, additional, Zubiri, Leyre, additional, Caplin, Joshua, additional, Tirard, Alice, additional, Sen, Prith, additional, Song, Yuhui, additional, Barth, Jaimie L., additional, Slowikowski, Kamil, additional, Nasrallah, Mazen, additional, Tantivit, Jessica, additional, Manakongtreecheep, Kasidet, additional, Arnold, Benjamin Y., additional, McGuire, John, additional, Pinto, Christopher J., additional, McLoughlin, Daniel, additional, Jackson, Monica, additional, Chan, PuiYee, additional, Lawless, Aleigha, additional, Sharova, Tatyana, additional, Nieman, Linda T., additional, Gainor, Justin F., additional, Juric, Dejan, additional, Mino-Kenudsen, Mari, additional, Sullivan, Ryan J., additional, Boland, Genevieve M., additional, Stone, James R., additional, Thomas, Molly F., additional, Neilan, Tomas G., additional, Reynolds, Kerry L., additional, and Villani, Alexandra-Chloe, additional

Published
2023
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18. Cardioprotective and Anti-Inflammatory Effects of FAM3D in Myocardial Ischemia-Reperfusion Injury

Author

Rhee, James, primary, Freeman, Rebecca, additional, Roh, Kangsan, additional, Lyons, Margaret, additional, Xiao, Chunyang, additional, Zlotoff, Daniel, additional, Yeri, Ashish, additional, Li, Haobo, additional, Guerra, Justin, additional, Guseh, J. Sawalla, additional, Kuznetsov, Alexandra, additional, Houstis, Nicholas, additional, Roh, Jason, additional, Damilano, Federico, additional, Liu, Xiaojun, additional, Silverman, Michael, additional, Kwong, Raymond, additional, Das, Saumya, additional, and Rosenzweig, Anthony, additional

Published
2023
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19. Association Between Immune Checkpoint Inhibitors With Cardiovascular Events and Atherosclerotic Plaque

Author

Drobni, Zsofia D., Alvi, Raza M., Taron, Jana, Zafar, Amna, Murphy, Sean P., Rambarat, Paula K., Mosarla, Rayma C., Lee, Charlotte, Zlotoff, Daniel A., Raghu, Vineet K., Hartmann, Sarah E., Gilman, Hannah K., Gong, Jingyi, Zubiri, Leyre, Sullivan, Ryan J., Reynolds, Kerry L., Mayrhofer, Thomas, Zhang, Lili, Hoffmann, Udo, and Neilan, Tomas G

Published
2020
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23. Major Adverse Cardiovascular Events and the Timing and Dose of Corticosteroids in Immune Checkpoint Inhibitor–Associated Myocarditis

Author

Zhang, Lili, Zlotoff, Daniel A., Awadalla, Magid, Mahmood, Syed S., Nohria, Anju, Hassan, Malek Z.O., Thuny, Franck, Zubiri, Leyre, Chen, Carol L., Sullivan, Ryan J., Alvi, Raza M., Rokicki, Adam, Murphy, Sean P., Jones-O’Connor, Maeve, Heinzerling, Lucie M., Barac, Ana, Forrestal, Brian J., Yang, Eric H., Gupta, Dipti, Kirchberger, Michael C., Shah, Sachin P., Rizvi, Muhammad A., Sahni, Gagan, Mandawat, Anant, Mahmoudi, Michael, Ganatra, Sarju, Ederhy, Stephane, Zatarain-Nicolas, Eduardo, Groarke, John D., Tocchetti, Carlo G., Lyon, Alexander R., Thavendiranathan, Paaladinesh, Cohen, Justine V., Reynolds, Kerry L., Fradley, Michael G., and Neilan, Tomas G.

Published
2020
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26. ASSOCIATION BETWEEN IMMUNE CHECKPOINT INHIBITORS WITH ATHEROSCLEROTIC PLAQUE PROGRESSION AND CARDIOVASCULAR EVENTS IN FEMALE PATIENTS WITH CANCER

Author

Suero-Abreu, Giselle A., primary, Drobni, Zsofia, additional, Gongora, Carlos A., additional, Silva, Thiago Quinaglia, additional, Taron, Jana, additional, Karady, Julia, additional, Gilman, Hannah, additional, Ho, Jor Sam, additional, Merkely, Bela, additional, Vago, Hajnalka, additional, Varga, Zoltan, additional, Sullivan, Ryan, additional, Zlotoff, Daniel A., additional, Reynolds, Kerry, additional, Foldyna, Borek, additional, Zanni, Markella, additional, and Neilan, Tomas G., additional

Published
2023
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27. ASSOCIATION OF USE OF NON-STEROIDAL ANTI-INFLAMMATORY DRUGS WITH ADVERSE CARDIOVASCULAR EVENTS IN PATIENTS TREATED WITH IMMUNE CHECKPOINT INHIBITORS

Author

Gong, Jingyi, primary, Drobni, Zsofia, additional, Silva, Thiago Quinaglia, additional, Zafar, Amna, additional, Reynolds, Kerry, additional, Gilman, Hannah, additional, Sullivan, Ryan, additional, Ho, Jor Sam, additional, Nohria, Anju, additional, Ricciotti, Emanuela, additional, Fitzgerald, Garret, additional, Zlotoff, Daniel A., additional, and Neilan, Tomas G., additional

Published
2023
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29. Mediators and mechanisms of immune checkpoint inhibitor‐associated myocarditis: Insights from mouse and human.

Author

Gong, Jingyi, Neilan, Tomas G., and Zlotoff, Daniel A.

Subjects
IMMUNE checkpoint proteins, DRUG side effects, MYOSIN, MYOCARDITIS, IMMUNE checkpoint inhibitors, CHEMOKINE receptors, IPILIMUMAB
Abstract

Summary: The broad application of immune checkpoint inhibitors (ICIs) has led to significant gains in cancer outcomes. By abrogating inhibitory signals, ICIs promote T cell targeting of cancer cells but can frequently trigger autoimmune manifestations, termed immune‐related adverse events (irAEs), affecting essentially any organ system. Among cardiovascular irAEs, immune‐related myocarditis (irMyocarditis) is the most described and carries the highest morbidity. The currently recommended treatment for irMyocarditis is potent immunosuppression with corticosteroids and other agents, but this has limited evidence basis. The cellular pathophysiology of irMyocarditis remains poorly understood, though mouse models and human data have both implicated effector CD8+ T cells, some of which are specific for the cardiomyocyte protein α‐myosin. While the driving molecular signals and transcriptional programs are not well defined, the involvement of chemokine receptors such as CCR5 and CXCR3 has been proposed. Fundamental questions regarding why only approximately 1% of ICI recipients develop irMyocarditis and why irMyocarditis carries a much worse prognosis than other forms of lymphocytic myocarditis remain unanswered. Further work in both murine systems and with human samples are needed to identify better tools for diagnosis, risk‐stratification, and treatment. [ABSTRACT FROM AUTHOR]

Published
2023
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30. 1254 Distinguishing T-cell responses in paired heart and tumor samples from patients with immune checkpoint-related myocarditis

Author

Blum, Steven, primary, Smith, Neal, additional, Zlotoff, Daniel, additional, Barth, Jaimie, additional, Ramesh, Swetha, additional, Kernin, Isabela, additional, Zubiri, Leyre, additional, McGuire, John, additional, Tirard, Alice, additional, Juric, Dejan, additional, Sullivan, Ryan, additional, Boland, Genevieve, additional, Mino-Kenudson, Mari, additional, Stone, James, additional, Thomas, Molly, additional, Reynolds, Kerry, additional, Neilan, Thomas, additional, and Villani, Chloe, additional

Published
2022
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31. 441 Checkpoint inhibitor-associated inflammatory arthritis is comprised of multiple clinical endotypes characterized by distinct transcriptional programs

Author

Reynolds, Gary, primary, Nasrallah, Mazen, additional, Smith, Neal, additional, Thomas, Molly, additional, Zubiri, Leyre, additional, Tirard, Alice, additional, McGuire, John, additional, Manakongtreecheep, Kasidet, additional, Tantivit, Jessica, additional, Blum, Steven, additional, Zlotoff, Daniel, additional, Chan, Elaina PuiYee, additional, Juric, Dejan, additional, Sullivan, Ryan, additional, Boland, Genevieve, additional, Luster, Andrew, additional, Schoenfeld, Sara, additional, Kohler, Minna, additional, Reynolds, Kerry, additional, and Villani, Chloe, additional

Published
2022
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34. Single-cell profiling of human heart and blood in immune checkpoint inhibitor-associated myocarditis.

Author

Blum, Steven Michael, primary, Zlotoff, Daniel A., additional, Smith, Neal, additional, Ramesh, Swetha, additional, Kernin, Isabela, additional, Sen, Pritha, additional, Zubiri, Leyre, additional, Tirard, Alice, additional, Nasrallah, Mazen, additional, Tantivit, Jessica, additional, Barth, Jaimie Lynn, additional, Juric, Dejan, additional, Sullivan, Ryan J., additional, Boland, Genevieve Marie, additional, Mino-Kenudson, Mari, additional, Stone, James, additional, Thomas, Molly, additional, Reynolds, Kerry Lynn, additional, Neilan, Tomas G., additional, and Villani, Alexandra-Chloé, additional

Published
2022
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35. Renin–angiotensin–aldosterone system inhibitors and survival in patients with hypertension treated with immune checkpoint inhibitors

Author

Drobni, Zsofia D., primary, Michielin, Olivier, additional, Quinaglia, Thiago, additional, Zlotoff, Daniel A., additional, Zubiri, Leyre, additional, Gilman, Hannah K., additional, Supraja, Sama, additional, Merkely, Bela, additional, Muller, Veronika, additional, Sullivan, Ryan J., additional, Reynolds, Kerry L., additional, Pittet, Michael J., additional, Jain, Rakesh K., additional, and Neilan, Tomas G., additional

Published
2022
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37. Abstract 11777: Global Radial Strain Predicts Cardiovascular Events in Patients With Myocarditis Related to the Use of Immune Checkpoint Inhibitors

Author

Silva, Thiago, primary, Awadalla, Magid, additional, Hassan, Malek, additional, Zafar, Amna, additional, Drobni, Zsofia, additional, Gongora, Carlos, additional, Mahmood, Syed S, additional, Zhang, Lili, additional, Chen, Carol, additional, EDERHY, Stephane, additional, Barac, Ana, additional, Jones-O'Connor, Maeve, additional, Murphy, Sean, additional, Coelho-filho, Otavio R, additional, Rizvi, Muhammad, additional, SAHNI, GAGAN, additional, Carlo Gabriele, Tocchetti G, additional, Hartmann, Sarah, additional, Gilman, Hannah, additional, Zatarain-Nicolás, Eduardo, additional, Mahmoudi, Michael, additional, Gupta, Dipti, additional, Michel, Caroline, additional, Mansilla, Ana Gonzalez, additional, Calles, Antonio, additional, Cabral, Marcella, additional, Fernandez-Aviles, Francisco, additional, Gavira, Juan Jose, additional, Gonzalez, Nahikari S, additional, Garcia de Yebenes Castro, Manuel Y, additional, Afilalo, Jonathan, additional, Sullivan, Ryan, additional, Ganatra, Sarju, additional, Zlotoff, Daniel, additional, Yang, Eric, additional, Heinzerling, Lucie, additional, Thuny, Franck, additional, Zubiri, Leyre, additional, Reynolds, Kerry, additional, Lyon, Alexander, additional, Fradley, Michael, additional, Thavendiranathan, Paaladinesh, additional, and Neilan, Tomas, additional

Published
2021
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38. Abstract 12425: Troponin Kinetics and Cardiovascular Events in Patients With Myocarditis After Immune Checkpoint Inhibitors Use

Author

Silva, Thiago, primary, Drobni, Zsofia, additional, Zafar, Amna, additional, Gongora, Carlos, additional, Zubiri, Leyre, additional, Zlotoff, Daniel, additional, Gong, Jingyi, additional, Lee, Charlotte, additional, Hartmann, Sarah, additional, Gilman, Hannah, additional, Villani, Alexandra-Chloe, additional, Sullivan, Ryan, additional, Reynolds, Kerry, additional, Zhang, Lili, additional, Nohria, Anju, additional, and Neilan, Tomas, additional

Published
2021
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39. Abstract 10187: Renin-Angiotensin-Aldosterone System Inhibitors and Overall Survival in Cancer Patients Treated with Immune Checkpoint Inhibitors

Author

Drobni, Zsofia D, primary, Michielin, Olivier, additional, Quinaglia, Thiago, additional, Zlotoff, Daniel, additional, Zubiri, Leyre, additional, Merkely, Béla, additional, Sullivan, Ryan, additional, Reynolds, Kerry, additional, Pittet, Mikael, additional, Jain, Rakesh, additional, and Neilan, Tomas, additional

Published
2021
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40. Immune checkpoint inhibitors for cancer and venous thromboembolic events

Author

Gong, Jingyi, primary, Drobni, Zsofia D., additional, Alvi, Raza M., additional, Murphy, Sean P., additional, Sullivan, Ryan J., additional, Hartmann, Sarah E., additional, Gilman, Hannah K., additional, Lee, Hang, additional, Zubiri, Leyre, additional, Raghu, Vineet K., additional, Karp-Leaf, Rebecca S., additional, Zafar, Amna, additional, Zlotoff, Daniel A., additional, Frigault, Matthew J., additional, Reynolds, Kerry L., additional, and Neilan, Tomas G., additional

Published
2021
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41. Rationale and design of the preserved versus reduced ejection fraction biomarker registry and precision medicine database for ambulatory patients with heart failure (PREFER-HF) study

Author

Abboud, Andrew, primary, Nguonly, Austin, additional, Bean, Asher, additional, Brown, Kemar J, additional, Chen, Roy F, additional, Dudzinski, David, additional, Fiseha, Neyat, additional, Joice, Melvin, additional, Kimaiyo, Davis, additional, Martin, Mackenzie, additional, Taylor, Christy, additional, Wei, Kevin, additional, Welch, Megan, additional, Zlotoff, Daniel A, additional, Januzzi, James L, additional, and Gaggin, Hanna K, additional

Published
2021
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44. Effect of a multidisciplinary Severe Immunotherapy Complications Service on outcomes for patients receiving immune checkpoint inhibitor therapy for cancer

Author

Zubiri, Leyre, primary, Molina, Gabriel E, additional, Mooradian, Meghan J, additional, Cohen, Justine, additional, Durbin, Sienna M, additional, Petrillo, Laura, additional, Boland, Genevieve M, additional, Juric, Dejan, additional, Dougan, Michael, additional, Thomas, Molly F, additional, Faje, Alex T, additional, Rengarajan, Michelle, additional, Guidon, Amanda C, additional, Chen, Steven T, additional, Okin, Daniel, additional, Medoff, Benjamin D, additional, Nasrallah, Mazen, additional, Kohler, Minna J, additional, Schoenfeld, Sara R, additional, Leaf, Rebecca K, additional, Sise, Meghan E, additional, Neilan, Tomas G, additional, Zlotoff, Daniel A, additional, Farmer, Jocelyn R, additional, Bardia, Aditya, additional, Sullivan, Ryan J, additional, Blum, Steven M, additional, Semenov, Yevgeniy R, additional, Villani, Alexandra-Chloé, additional, and Reynolds, Kerry L, additional

Published
2021
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47. Pericardial disease in patients treated with immune checkpoint inhibitors

Author

Gong, Jingyi, primary, Drobni, Zsofia Dora, additional, Zafar, Amna, additional, Quinaglia, Thiago, additional, Hartmann, Sarah, additional, Gilman, Hannah K, additional, Raghu, Vineet K, additional, Gongora, Carlos, additional, Sise, Meghan E, additional, Alvi, Raza M, additional, Zubiri, Leyre, additional, Nohria, Anju, additional, Sullivan, Ryan, additional, Reynolds, Kerry L, additional, Zlotoff, Daniel, additional, and Neilan, Tomas G, additional

Published
2021
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48. Impact of multidisciplinary severe immunotherapy complication service on outcomes for cancer patients receiving immune checkpoint inhibition.

Author

Zubiri, Leyre, primary, Molina, Gabriel E., additional, Mooradian, Meghan, additional, Durbin, Sienna, additional, Dougan, Michael, additional, Thomas, Molly, additional, Faje, Alexander, additional, Rengarajan, Michelle, additional, Guidon, Amanda C, additional, Chen, Steven T., additional, Nasrallah, Mazen, additional, Kohler, Minna, additional, Sise, Meghan, additional, Neilan, Tomas G, additional, Zlotoff, Daniel A, additional, Bardia, Aditya, additional, Sullivan, Ryan J., additional, Semenov, Yevgeniy R., additional, Villani, Alexandra C, additional, and Reynolds, Kerry Lynn, additional

Published
2021
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49. ASSOCIATION BETWEEN INCIDENTAL STATIN USE AND SKELETAL MYOPATHIES IN PATIENTS TREATED WITH IMMUNE CHECKPOINT INHIBITORS

Author

Drobni, Zsofia, primary, Murphy, Sean, additional, Alvi, Raza, additional, Lee, Charlotte, additional, Gong, Jingyi, additional, Mosarla, Ramya, additional, Rambarat, Paula, additional, Hartmann, Sarah, additional, Gilman, Hannah, additional, Zubiri, Leyre, additional, Raghu, Vineet, additional, Sullivan, Ryan, additional, Zafar, Amna, additional, Zlotoff, Daniel, additional, Dougan, Michael, additional, Sise, Meghan, additional, Guidon, Amanda, additional, Reynolds, Kerry, additional, and Neilan, Tomas, additional

Published
2021
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50. CIRCULATING GUT METABOLITES IN PATIENTS WITH HEART FAILURE WITH PRESERVED, REDUCED OR RECOVERED EJECTION FRACTION, AND IN THE AGE- AND SEX-MATCHED CONTROLS: RESULTS FROM THE PRESERVED VS. REDUCED EJECTION FRACTION BIOMECHANICAL MARKER REGISTRY FOR AMBULATORY HEART FAILURE PATIENTS (PREFER-HF) STUDY

Author

Fiseha, Neyat, primary, Abboud, Andrew, additional, Nguonly, Austin, additional, Bean, Asher, additional, Dudzinski, David, additional, Chen, Roy, additional, Wei, Kevin, additional, Zlotoff, Daniel, additional, Brown, Kemar, additional, Joice, Melvin, additional, Shah, Svati, additional, Shah, Sanjiv, additional, Hsue, Priscilla, additional, Januzzi, James, additional, and Gaggin, Hanna, additional

Published
2021
Full Text
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