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Numerical simulation technology is a crucial tool for reducing costs and increasing efficiency in the wind power industry. However, with the development of large-scale wind turbines, the computational cost of numerical simulation has gradually increased. This paper uses the geometric similarity, structural similarity criterion, Reynolds similarity and boundary layer theory to establish a scaled model of the geometric three-dimensional shape, composite material, and finite element mesh of large wind turbine blades. The study analyzes the aerodynamic, gravitational, and centrifugal load variations within the scaled model. The proportional relationship between the scaled model’s operating parameters, the numerical simulation’s environmental parameters, and the mechanical response parameters is established. These parameters are coordinated to ensure the similarity of the blade structure and the fluid dynamics. For a geometric scale factor of 0.316, the relative difference in maximum deflection is 4.52%, with a reduction in calculation time by 48.1%. On the premise of ensuring the calculation accuracy of the aerodynamic and structural response of the blade, the calculation efficiency is effectively improved.

Background Artificial intelligence platforms, like Viz.ai with large vessel occlusion detection, have been used for disease detection and interprovider communication. Whether this software expedites patient transfer and evaluation for treatment needs further exploration. Methods A single‐center retrospective registry was queried for patients with acute large vessel occlusion of the intracranial internal carotid, middle cerebral M1 or M2 segments, or basilar artery treated in a comprehensive stroke network (8 spokes, 1 hub) for 6 months pre‐ and post‐implementation of the Viz large vessel occlusion platform (excluding a 1‐month “washout” period). Robust regression was used to summarize time from initial hospital contact to arterial puncture (primary outcome) between periods, with prespecified subgroup analyses, which were assessed using interaction terms. Results Of the 132 patients (n = 58 preintervention), there were nonsignificantly fewer patients undergoing endovascular therapy in the postintervention period (86.2% preintervention versus 73.0% postintervention; P = 0.07). Among patients who underwent endovascular therapy (n = 50 preintervention, n = 54 postintervention), there was a nonsignificant reduction in time from first contact to arterial puncture (median 155 minute preintervention versus 116 minute postintervention; P = 0.10); however, this became significant in adjusted robust regression accounting for stroke severity, age, Alberta Stroke Program Early Computed Tomography Scale score, daytime versus nighttime and weekend versus weekday arrival, and use of perfusion imaging (β −20.9 [95% CI, −40.5 to −1.4)]. There was also a significant interaction observed for the association between spoke versus hub arrival and the Viz large vessel occlusion period, with shorter intervals observed for transferred patients (n = 32 preintervention with a median of 169 versus 142 minutes for n = 33 postintervention; Pinteraction

The mechanical properties of particulate materials are among the main factors affecting the grinding and crushing of ball mills. To quantitatively describe the relationship between the breakage characteristics and the stress intensity of irregular particulate materials, this study takes iron ore particles as the research object. It selects five particle size grades of iron ore particles (−4.75 + 3.35, −6.7 + 4.75, −9.5 + 6.7, −13 + 9.5, and −16 + 13 mm) for single particle strength tests. The results showed that the iron ore particles were irregular with certain slenderness and flatness characteristics. The larger the particle size, the lower the sphericity, and the greater the degree of irregularity. As the size of the iron ore particles increased, the number of peak points on the pressure–displacement curve of the particles increased significantly, and the crushing load increased. The single-particle strength of the iron ore particles followed a Weibull distribution, and the Weibull modulus parameter ranged between 2.03 and 2.49.

The liner is a wear-prone component in ball mills, subject to continuous impacts, squeezing, and abrasion from the grinding media during operation. Its service performance directly affects the working efficiency of the ball mill. The service life of mining ball mill liners is about 8 months, and frequent downtimes occur due to liner wear and loss of effectiveness, with liner replacement accounting for about 6% of the total cost, resulting in huge economic losses. This paper focuses on a Φ305 mm × 150 mm experimental ball mill, using the discrete element software Rocky Discrete Element Method (DEM) (software version number Rocky 2022 R2) for simulation modeling analysis. With Φ10 mm and Φ20 mm mono-size particle simulations serving as reference groups, this study investigates the motion states and liner abrasion patterns under different liner heights for both sizes of grinding media in Equilibrium Quality Manufacturer (EQM) and Original Equipment Manufacturer (OEM) gradations. The results indicate that the impact of liner height on the wear of the ball mill liners is related to the size and gradation of the grinding media. The degree of liner wear from highest to lowest is as follows: EQM > Φ20 mm > OEM > Φ10 mm. Due to the effect of the cylinder end cap, the wear at the axial center of the ball mill liner is more severe than at both ends, and the wear on the facing side of the liner is more severe than on the backside. A thorough study of the influence of ball mill grinding media gradation on the wear pattern of liners is of great theoretical significance for optimizing liner structures, improving grinding efficiency, and promoting energy saving and cost reduction in ball mills. This study provides theoretical guidance for understanding the mechanisms behind liner wear in ball mills and predicting the liner lifespan.

A ball mill is a type of complex grinding device. Having knowledge of its charge-load behavior is key to determining the operating conditions that provide the optimum mill throughput. An elaborate description of the charge movement inside the ball mill is essential. This study focuses on a laboratory-scale ball mill and utilizes a discrete element simulation model to investigate the impact of mill speed and ball filling on charge-load behavior. Initially, the EDEM 2.7 (Engineering Discrete Element Method) software contact parameters were calibrated through heap-angle experiments. Subsequently, four charge-motion characteristic parameters were defined and analyzed based on Powell’s theory to understand the variations in charge-load behavior. This research proposes a theoretical calculation model for predicting power in a ball mill, highlighting the significance of the CoC (Center of Circulation) and CoM (Center of Mass) in reflecting changes in charge-load behavior. The theoretical model for mill-power prediction is effective and aligns well with the EDEM simulation and experimental results, providing valuable insights for optimizing large-scale ball mill structures and controlling charge motion during production.

The skip liner is a primary wearing component that is subjected to direct impacts and friction from coal in the mineshaft hoisting system. In this research, a skip tester was designed to investigate the impact wear characteristics of liner such as the wear quantity, impact load, and wear morphology under different impact velocities and coal types. The discrete element method (DEM) simulation was used to predict the wear distribution and load behavior for different coal particle sizes. The experimental results show that the wear failure of the liner is due to impact wear and abrasive wear. The impact velocity has significant effects on all three evaluation indices, and a larger impact velocity causes a greater wear degree. Three evaluation indices show that the coking coal causes a higher impact wear. In addition, the DEM simulation results show that the coal particle size has a significant influence on the impact load of the liner, the normal cumulative contact energy increases with the increase of the coal particle size, but the tangential cumulative contact energy decreases with the increase of the coal particle size. The use of a DEM simulation can predict the regions subjected to wear in the skip and the dynamic behavior of the coal particles, which provide a method for optimizing the parameters of coal particles and for improving the service life of the skip liner.

For investigating the effect of mullite as a reinforced fiber of the non-asbestos brake friction material on the performance of brake pads, mullite reinforced composites with different contents (5% and 10%) and shapes (powder-based and fiber-based) were developed, and the physical and mechanical properties of the composites were analyzed. The tribological properties of the composites were tested by a Chase tester followed by the IS-2742 standard, and the worn surface was investigated by three-dimensional surface topography and SEM. The results show that the brake friction material with 5% powdered mullite performs best, having the highest stable friction performance (0.86), the lowest wear rate (3%), the lowest friction variation performance (0.263), and the best fade-recovery performance. With the increase of mullite content, the friction variation, wear resistance, and friction stability of the composites become worse. Meanwhile, the performance of powder-based mullite composites is better than that of fiber-based. The worn surface analysis shows that the fiber-based mullite composite has a higher surface roughness, fewer contact platforms, more wear debris, and peeling pits. In contrast, the powder-based mullite composites have a better surface performance. It provides a practical basis for mullite-reinforced non-asbestos brake friction materials.

Objective: To investigate the effect of ethyl acetate extract from Celastrus orbiculatus (COE) on gastric cancer cell apoptosis and reveal its underlying molecular mechanism. In addition, it was aimed to stablish a theoretical basis for the clinical application of Celastrus orbiculatus in the gastric cancer treatment.Material and Methods: Western blot and RT-qPCR were used to detect mRNA and protein expression of PHB in gastric cancer and adjacent tissues. MTT method was used to detect the COE effect on the proliferation of AGS cells and to determine the 50% inhibitory concentration COE on these cells. COE effect on AGS apoptosis was evaluated by flow cytometry. Changes in apoptosis-related proteins expression in AGS cells were detected by western blot and changes in mitochondrial membrane potential were detected by JC-1 fluorescence staining. PHB expression was knocked down in AGS cells by lentiviral-mediated RNA interference. The COE antitumor effect was assessed in vivo using a subcutaneous transplantation tumor model in nude mice and in vivo fluorescence tracing technique in small animals.Results: The clinical samples analysis results showed that the PHB expression in gastric cancer samples was significantly higher than in corresponding adjacent tissues. MTT results showed that the AGS cell proliferation was significantly inhibited. RT-qPCR and western blot results showed that COE can significantly inhibit the PHB mRNA and protein expression, respectively. Flow cytometry analysis showed that COE was able to significantly promote AGS cell apoptosis. Western blot results also indicated that apoptosis-related protein expression changed significantly; BCL-2 expression significantly reduced while the Caspase-3 and Bax expression significantly increased after COE treatment. JC-1 fluorescence staining results showed that COE changed the mitochondrial membrane potential and activated the mitochondrial apoptosis pathway. Furthermore, in vivo experiments results demonstrated that the growth of subcutaneous transplanted tumor was significantly inhibited by the PHB knockdown and by the COE intragastric administration.Conclusion: COE can significantly promote apoptosis of human gastric cancer cells, which can be achieved by inhibiting PHB expression, thus altering the structure and function of mitochondria and activating the mitochondria apoptosis pathway. The antitumor effect of COE has also been proved in vivo.

Ball mill is the widely used comminution device for the size reduction of iron ore particles, yet the underlying mechanisms of heat transfer and thermal breakage inside the mills heretofore are not deeply understood. Therefore, the Discrete element method was carried out to study the effect of operating parameters on charge temperature, and the batch grinding experiments of iron ores were conducted to verify the heating temperatures using a laboratory ball mill. Results show that increasing mill speed will result in the charge temperature increasing initially and then decreasing. The temperature fields of the charge and load behavior remain approximately the same for the different ball filling. The main findings of this study are that the heating temperature can contribute to enhancing the breakage behavior of iron ore particles, and correspondingly the optimal feed sizes for different heating temperatures are determined to be 2.48 mm, 2.63 mm, 2.78 mm, and 3.59 mm, respectively.

Cis-2-dodecenoic acid (i.e., Burkholderia cenocepacia Diffusible Signal Factor, BDSF), a signaling molecule produced by Burkholderia cenocepacia but not by Candida albicans, can prevent Candida albicans hyphal formation. The mechanism by which BDSF controls the morphological switch of C. albicans is still unknown. To address this issue, we used the cDNA microarray method to investigate the differential expression of genes in C. albicans in the presence and absence of BDSF. The microarray result indicated that 305 genes were significantly different in the expression level. This included the downregulation of 75 genes and the upregulation of 230 genes. Based on the microarray data, a mutant library was screened to search for genes, once mutated, conferred insensitivity to BDSF. The results showed that the repressors (Ubi4 and Sfl1 proteins) and the activator (Sfl2 protein) of filamentous growth are involved in the BDSF regulation of hyphal morphogenesis. Ubi4, an ubiquitin polypeptide that participates in ubiquitin-mediated protein turnover, is the protein required for the degradation of Sfl2. Sfl1 and Sfl2 proteins antagonistically control C. albicans morphogenesis. In the hyphal induction condition, the amount of Ubi4 and Sfl1 protein increased rapidly with the exogenous addition of BDSF. As a result, the protein level of the activator of filamentous growth, Sfl2, decreased correspondingly, thereby facilitating the C. albicans cells to remain in the yeast form.

Aiming at addressing the load behavior of iron ore particles in a ball mill, a design of experimental method was used to define a series of discrete element method simulation conditions with two factors being the mill speed and lifter height. The key feature locations of impact toe, bulk toe, shoulder, and head positions were identified visually to determine the load behavior of the charge. To allow the irregular particle shape to be accurately determined, a quick and accurate sphere-clump method was employed in modeling the geometrical model of irregular shape. The results show that the dependence of the impact toe and head on mill speed is higher than its dependence on the lifter height with a correlation of −0.923 and 0.97, respectively. The shoulder changes approximately invariant with the mill speed and varies little with the lifter height. The bulk toe of particles appears to be invariant to the mill speed as well as the lifter height, resulting in the approximately same inclination of the chord joining the shoulder and bulk toe.

To investigate the impact of lifting velocity and container shape on angle of repose, the fixed-base cylinder method was performed using three types of container shape. The container shape was lifted a series of lifting velocities. Six size fractions of iron ore particles ranging from coarser to fine particles were used as the test materials. And the sand-pile calibration method was then used to calibrate the contact parameters of iron ore particles. Results show angle of repose decreased exponentially with the lifting velocity, while it appeared approximately to be invariant to particle shape, for all size fractions. The sand pile highly depends on the container shape at a low lifting velocity but appears to be invariant to particle size for a high lifting velocity. And then a predictive equation is established and a very close agreement between the predicted and measured angle of repose is attained. Finally, a series of DEM simulations considering the irregular particle shape are conducted by means of sphere clump method to calibrate the contact parameters and are in good visual agreement with the experimental results, indicating the “tuned” contact parameters as well as the applicability of the predicted equation.

Using the largest semi-autogenous grinding mill in China as a model, collision energy was analyzed on the basis of the multi-layer kinematics of the steel balls. First, the kinematic equation of the steel balls was obtained by considering the multi-layer characteristics of the steel balls. Second, the collision energy of the inner-layer steel balls was addressed according to its kinematic characteristics. Finally, the total collision energy per unit time was obtained. Results show that the leaving angle decreases as the mill speed ratio increases and as the radius ratio increases, but the leaving velocity increases linearly. Moreover, a discontinuity point of the tangential collision velocity occurs at an angle factor β = 0, and the angle factor β is divided into two intervals: [−3, 0] and [0, 1.5]. The leaving angles corresponding to a tangential velocity equal to zero are calculated to be 1.185 and 0.7854 rad in the two intervals. In addition, the sum collision velocity increases when β is less than zero, but it decreases sharply above zero. The maximum total collision energy per unit time occurs at 84.2% of the mill speed corresponding to the optimal mill speed ratio.

The impact behavior between the charge and lifter has significant effect to address the mill processing, and is affected by various factors including mill speed, mill filling, lifter height and media shape. To investigate the multi-body impact load behavior, a series of experiments and Discrete Element Method (DEM) simulations were performed on a laboratory-scale mill, in order to improve the grinding efficiency and prolong the life of the lifter. DEM simulation hitherto has been extensively applied as a leading tool to describe diverse issues in granular processes. The research results shown as follows: The semi-empirical power draw of Bond model in this paper does not apply very satisfactorily for the ball mills, while the power draw determined by DEM simulation show a good approximation for the measured power draw. Besides, the impact force on the lifter was affected by mill speed, grinding media filling, lifter height and iron ore particle. The maximum percent of the impact force between 600 and 1400 N is at 70–80% of critical speed. The impact force can be only above 1400 N at the grinding media filling of 20%, and the maximum percent of impact force between 200 and 1400 N is obtained at the grinding media filling of 20%. The percent of impact force ranging from 0 to 200 N decreases with the increase of lifter height. However, this perfect will increase above 200 N. The impact force will decrease when the iron ore particles are added. Additionally, for the 80% of critical speed, the measured power draw has a maximum value. Increasing the grinding media filling increases the power draw and increasing the lifter height does not lead to any variation in power draw.