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We investigated the diagnostic value of the tumor marker CA724 in patients with primary gastric cancer. One hundred forty-six patients with primary gastric cancer were selected as the observation group; 89 patients with gastritis treated in the same period were included in the control group 1; 91 patients with healthy physical examination during the same period were included in the control group 2. Electrochemiluminescence immunoassay was used to determine the level of carbohydrate antigen CA724 in each group; the pathological data of the observation group were consulted, and the expression level of tumor marker CA724 under different pathological conditions was analyzed; ROC curve was drawn to evaluate the diagnostic value of CA724 in gastric cancer and gastritis. The level of CA724 in primary gastric cancer patients was significantly correlated with tumor diameter, tumor stage, differentiation type, and lymph node metastasis. The ROC curve was drawn with a CA724 cutoff value of 7.94 U/Ml. The AUC value of CA724 in primary gastric cancer patients was 0.815, with a diagnostic sensitivity of 84.68% and a specificity of 71.95%. In conclusion, CA724 was highly expressed in patients with primary gastric cancer, which can achieve the diagnostic differentiation of gastric cancer and gastritis, and obtain a high diagnostic efficiency, providing a reference basis for clinical diagnosis and treatment.

The authors assessed the occurrence and severity of cement leakage (CL) following percutaneous vertebroplasty (PVP) for osteoporotic vertebral compression fractures (OVCFs) performed using front-opening cannulas (FOCs) vs side-opening cannulas (SOCs). This retrospective cohort study included 811 patients with single-level OVCFs who underwent PVP between March 2016 and September 2018. The 264 patients who met the inclusion criteria were divided into two groups according to whether the procedure was performed using a FOC (n=128) or a SOC (n=136). Visual analog scale score, Oswestry Disability Index, local kyphotic angle, vertebral height, amount of bone cement injected, and rate of CL were compared between the groups. Types of CL were classified according to postoperative computed tomography. The CL types were further classified according to severity (mild and severe). Visual analog scale score, Oswestry Disability Index, local kyphotic angle, and vertebral height were all significantly improved after surgery. The total incidence of CL was significantly higher for FOCs than for SOCs ( P =.001). Similarly, the occurrence of the CL subtypes was significantly higher for FOCs than for SOCs (B type, P =.033; C type, P =.01; and S type, P =.015). Analysis of CL type severity revealed that the rates of severe D type (intradiskal leakage category of the C type) and severe S type were significantly lower for SOCs than for FOCs ( P =.001), while the incidence of severe B type leaks was not significantly different between the groups ( P =.443). Percutaneous vertebroplasty performed using SOCs decreases the incidence and severity of D type and S type CL compared with FOCs. Secondary classification of CL could help physicians better understand the severity of leakage and select a more appropriate surgical approach to reduce CL. [ Orthopedics . 2021;44(3):134–140.]

In this paper, a novel frequency reconfigurable filtering antenna is proposed for modern wireless communication systems. The feed network is composed of a stepped impedance resonator filter and a 5...

Simple Summary The freezing stress during overwintering brings great challenges to the normal growth of Camellia sinensis. The current research on C. sinensis mainly focuses on cold resistance, but less on freezing resistance. In the present study, the transcriptome and metabolome of C. sinensis under freezing stress were studied. Results showed that Pyr/PYL-PP2C-SnRK2 played a critical role in the signal transduction of freezing stress. Three metabolic pathways including phenylpropanoid biosynthesis, flavone and flavonol biosynthesis, and flavonoid biosynthesis contributed to the freezing resistance of C. sinensis. This study provides substantial insights for the breeding of C. sinensis. Abstract Freezing stress in winter is the biggest obstacle to the survival of C. sinensis in mid-latitude and high-latitude areas, which has a great impact on the yield, quality, and even life of C. sinensis every year. In this study, transcriptome and metabolome were used to clarify the freezing resistance mechanism of 60-year-old natural overwintering C. sinensis under freezing stress. Next, 3880 DEGs and 353 DAMs were obtained. The enrichment analysis showed that pathways of MAPK and ABA played a key role in the signal transduction of freezing stress, and Pyr/PYL-PP2C-SnRK2 in the ABA pathway promoted stomatal closure. Then, the water holding capacity and the freezing resistance of C. sinensis were improved. The pathway analysis showed that DEGs and DAMs were significantly enriched and up-regulated in the three-related pathways of phenylpropanoid biosynthesis, flavone and flavonol biosynthesis, and flavonoid biosynthesis. In addition, the carbohydrate and fatty acid synthesis pathways also had a significant enrichment, and the synthesis of these substances facilitated the freezing resistance. These results are of great significance to elucidate the freezing resistance mechanism and the freezing resistance breeding of C. sinensis.

In this paper, an on-wafer S-parameter calibration method and a complete set of TRL calibration kits are presented. Both the calibration kits as well as the micro coaxial probes are designed based on a MEMS process. An eight-term error model is used to do the calibration and the calibration process is performed using the EM full wave simulation software. Moreover, we design these calibration kits and the micro-coaxial probes in order to verify some experimental results from our previous work, that the crossover effect between the probes as well as the surface wave degraded the measured rejection of a W band MEMS filter. As a result, the simulation results fit the measured result well, demonstrating the validity of the probes and the kits design, future work can be delegated to the design of more sophisticated calibration kits and algorithms to alleviate the aforementioned problems.

The design of a rectangular-coaxial vertical interconnection structure based on micro-additive manufacturing technology is presented in this paper. This vertical interconnection is realized with quasi-coaxial structure with square cross section composed of Sn-based solder balls and is designed to connect coaxial transmission lines at different layers. Simulation results show that the insertion loss is $\lt 0.2$ dB and the S 11 is $\lt -20$ dB from 0.1-110 GHz. In addition, the isolation between two vertical interconnections is higher than 50 dB.

Objective To evaluate the influence of insufficient bone cement distribution on outcomes following percutaneous vertebroplasty (PVP). Methods This retrospective matched-cohort study included patients 50–90 years of age who had undergone PVP for single level vertebral compression fractures (VCFs) from February 2015 to December 2018. Insufficient (Group A)/sufficient (Group B) distribution of bone cement in the fracture area was assessed from pre- and post-operative computed tomography (CT) images. Assessments were before, 3-days post-procedure, and at the last follow-up visit (≥12 months). Result Of the 270 eligible patients, there were 54 matched pairs. On post-operative day 3 and at the last follow-up visit, significantly greater visual analogue scale (VAS) pain scores and Oswestry Disability Index (ODI) scores were obtained in Group B over Group A, while kyphotic angles (KAs) and vertebral height (VH) loss were significantly larger in Group A compared with Group B. Incidence of asymptomatic cement leakage and re-collapse of cemented vertebrae were also greater in Group A compared with Group B. Conclusions Insufficient cement distribution may relate to less pain relief and result in progressive vertebral collapse and kyphotic deformity post-PVP.

Epidemiological investigation is one of the main means of controlling the outbreak of COVID-19. It has been proven to be effective, however, has a bottleneck that the infected person has to be questioned about his recent trajectory before any quarantine action could be taken, while sometimes trajectory information might not be timely and accurately obtained. In this paper, we propose an epidemiological investigation method which resort to artificial intelligence for extracting people’s preferences and social relationship from their historical trajectory patterns. Trajectory data used in our epidemiological investigation method may include time, location, Point-of-Interest (POI), as well as Behavior-of-Interest (BOI). All of these attributes in human’s trajectory are embedded into different channels in the proposed model and then fed into a classifier or a clusterer for serving different purposes. In our experiments, we applied the proposed method on a synthetic data set to conduct a classification task, and on a real data set for a clustering task. Both tasks confirm that the proposed method is effective and thus could be used to guide the preventive measures.

A co-design of circularly polarized (CP) filtering antenna is proposed in this paper. The filtering antenna system consists of two λ/2 open-loop resonators which improve the selectivity of passband and a corner-truncated patch which works as both a radiating element and the last stage resonator of filtering network to form an extra minima/pole. Furthermore, an attenuation on the high side of passband is introduced through cross coupling between the first open-loop resonator and CP antenna. By vertically and seamlessly integrating the patch with open-loop resonators, a third-order filtering response is obtained while transition loss is removed. Additionally, the ground plane is shared by the patch and the filtering network to reduce size occupation. An antenna prototype has been fabricated and measured, good agreement is achieved between measurements and simulations. In conclusion, proposed antenna reaches a more compact structure due to multiple functions realized by the patch, a better frequency selectivity and high rejection due to the extra attenuation pole introduced through cross coupling between patch and the first resonator.

Five trace elements including Zn, Cu, Cd, Cr and As were investigated in surface water from ten typical sampling sites in Honghu Lake. The consequence indicated that all of the detected trace element levels were within the allowed standard of China’s safe water guideline. The hazard quotients (HQ) and the hazard index (HI) value levels of all the five heavy metals in all sampling sites did not exceed the acceptable risk limits of non-carcinogenic value through the selected assessment method. Pearson’s correlation analysis and principal component analysis (PCA) indicated that Zn and Cu mainly originated from the natural alluviation and non-point agricultural sources, whereas Cr and As were mainly derived from industrial effluents. Moreover, Cd mainly originated from both non-point agricultural and industrial pollution sources. In addition, cluster analysis (CA) implied that cluster 1 (including S3, S5, S6 and S10) was considered the set of high pollution sites and cluster 2 (including S4 and S9) was identified as the set of moderate pollution sites.

Heavy metals (Cr, Cu, Zn, Pb, Cd) concentrations and fractions in surface sediments from Honghu Lake were detected by an atomic absorption spectrophotometer and Simple Bioavailability Extraction Test (SBET) from 11 typical sites to explore their spatial distribution, bioavailability and sources. Results showed the mean Igeos and ecological risk degrees decreased in the order of Cd>Cu>Cr>Pb>Zn and Cd>Cu>Pb>Cr>Zn. The metals’ bioavailability estimated by SBET decreased in the general order of Cu>Pb>Cd>Zn>Cr. Under integrated consideration of metal enrichment, ecological risk and bioavailability, it obviously made the decision-makers confused to identify final priority pollutants and priority areas. Thus, a probabilistic integrated ecological risk assessment method (PIERA) was formulated based on the potential ecological risk index (PER), SBET and triangular fuzzy numbers for synthetically assessing metal enrichment, ecotoxicity and bioavailability. With the help of PIERA, Cd was finally regarded as the risk priority metal due to the integrated potential eco-risk of Cd made the average contribution of 86.4% to the integrated RIs. Moreover, the areas around S5 and S2 were regarded as the risk priority areas. The case application of PIERA revealed that this improved method is of a better resolving ability which scientifically supplies the integrated information of enrichment, bioavailability and systematic uncertainty for decision-makers compared with the other prevalent indexes (SQGs, Igeo, PER). The consequence of the Pearson correlation analysis, distribution analysis and field investigation indicated that Cd mainly originated from both non-point agricultural and industrial pollution sources.

Highlights • We established a TaqMan-based real-time RT-PCR assay for the detection of a novel swine diarrhea virus SADS-CoV. • The assay in this study was of high sensitivity, specificity and reproducibility. • We compared the accuracy between conventional PCR and TaqMan-based RT-PCR assay with adequate clinical samples. • This approach will help to provide knowledge on epidemiology and pathogenesis studies of SADS-CoV., Swine acute diarrhea syndrome coronavirus (SADS-CoV) is a novel coronavirus which was first reported in southern China in 2017. It can cause severe diarrhea disease in pigs. In order to detect this new emerging virus rapidly and reliably, a TaqMan-based real-time RT-PCR assay was established in this study. Specific primers and probe were designed and synthesized based on the conserved region within the N gene of the viral genome. Results showed that the lowest limit of detection was 3.0 × 101 copies/μL. This approach was specific for SADS-CoV, and there were no cross-reaction observed against other 15 swine viruses. It was 10 times more sensitive than the conventional PCR and gave higher SADS-CoV positive detection rate (70.69%, 123/174) than the conventional PCR (51.15%, 89/174) from clinical samples. These data indicated that the TaqMan-based real-time RT-PCR assay established here was an effective method with high sensitivity, specificity and reproducibility for faster and more accurate detection and quantification of SADS-CoV.

In the pursuit of fuel economy improvement and emission reduction, a trajectory optimization-based engine multioperating-point control strategy is proposed in this paper for the auxiliary power unit (APU) in an extended range electric vehicle. This strategy design deeply considers the transient process of the operating point switching that somehow influences the engine fuel economy and emission, and was often ignored. First, a combined cost MAP fully integrating several indices, including fuel consumption rate, CO, HC, and NOx emissions, is presented to synthetically evaluate the effect of the operation trajectory. Then an improved genetic algorithm, in terms of computational load reduction and convergence improvement, is employed to optimize the engine trajectory in the transient operating point switching process of the APU system, so that it is able to perform with the best fuel consumption and emissions. Finally, simulated and experimental results indicate that the proposed control strategy has obvious improvements in fuel economy and emissions, compared with conventional ones.

Ethnopharmacological relevance Plastrum testudinis (PT) is a kind of single traditional Chinese medicine that can tonify kidney and strengthen bone. Plastrum testudinis extract (PTE) has been approved to promote the osteogenic differentiation of bone marrow-derived mesenchymal stem cells in vitro. However, the mechanism by which PTE reduces osteoclast differentiation has not yet been reported. Aim of the study To explore the potential of PTE as a therapeutic treatment for bone loss caused by senile osteoporosis (SOP). Materials and methods We evaluated whether PTE could inhibit RANKL-induced osteoclast differentiation both in vitro and in vivo, and investigated PTE-induced phenotypes of human peripheral blood monocytes. Results We found that PTE inhibited osteoclast differentiation and bone resorption in vitro in a concentration-dependent manner and that PTE treatment is most effective during the early stages of osteoclastogenesis. Moreover, we found that PTE could block the NF-κB signaling pathway in vitro, leading to the down-regulation of osteoclast-specific genes including C-FOS and NFATC1. The results from our in vivo mouse study suggest that PTE treatment suppresses osteoclast formation and mitigates bone loss caused by SOP. Notably, we also found that PTE inhibited RANKL-induced osteoclast differentiation in human peripheral blood monocytes. Conclusion Our results suggest that PTE treatment suppresses osteoclastogenesis and ameliorates bone loss caused by SOP by selectively blocking the nuclear translocation of NF-κB/p50.

An optically transparent and ultra-wideband meta-material absorber (MA) using multi-layer structure is proposed in this paper. The MA is made of indium thin oxide (ITO) films and transparent plastic. According to the simulation, the MA realizes high absorption over 80% during 3 ～24.5 GHz for both transverse electric (TE) and transverse magnetic (TM) incidences. The MA also shows stable absorbing capability for oblique incidences of < 40°. The optical transparency and good absorption performance make the MA can be a promising candidate for the application of transparent stealth.

Swine acute diarrhea syndrome coronavirus (SADS-CoV) is a newly identified enteric alphacoronavirus that causes fatal diarrhea in newborn piglets in China. Here, we propagated a virulent strain SADS-CoV/CN/GDWT/2017 in Vero cells for up to 83 passages. Four strains of SADS-CoV/GDWT-P7, -P18, -P48 and -P83 were isolated and characterized. Sequence alignments showed that these four novel strains exhibited 16 nucleotide mutations and resultant 10 amino acid substitutions in open reading frame 1a/1b, spike, NS3a, envelope, membrane and nucleocapsid proteins. Furthermore, a 58-bp deletion in NS7a/7b was found in P48 and P83 strains, which led to the loss of NS7b and 38 amino acid changes of NS7a. Pig infection studies showed that the P7 strain caused typical watery diarrhea, while the P83 strain induced none-to-mild, delayed and transient diarrhea. This is the first report on cell adaption of a virulent SADS-CoV strain, which gives information on the potential virulence determinants of SADS-CoV.

In this paper, a fifth order coaxial bandpass filter with out-of-band rejection based on 3D MMFT technique is designed and presented. Short-circuited $\lambda/2$ transmission lines are adopted to construct resonators and coupled with each other through $\lambda/4$ transmission lines. Additionally, extra supporting structure is needless due to direct connection between internal and external conductor. Meanwhile, the fabrication procedure becomes simplified and more efficient. Coupling coefficients and external quality factor used in filtering design can be reached freely by adjusting positions of intersections among resonators and $\lambda/4$ transmission lines, and all the dimensions of the filter can be analytically worked out. Furthermore, attenuation poles are created on the high side of passband due to long branches of $\lambda/2$ transmission line resonators. In order to verify the feasibility of the design method, a W-band filter prototype is demonstrated and simulated, showing good agreement with analytical results.

The accurate and quantitative analysis of microRNA (miRNA) expression is critical for biomedical research and clinical theranostics. In this study, we report a novel sensor for the sensitive detection of miRNA based on a duplex-specific nuclease (DSN)-assisted dual signal amplification strategy. A chimeric probe (DNA/2-OMe-RNA) that consists of a miRNA recognition DNA sequence and a Taqman probe hybridization RNA sequence (2'-O-methyl RNA) was designed and synthesized. One molecule of target miRNA can trigger cyclical cleavage of the chimeric probes to produce 2'-O-methyl RNA by DSN in the first round of amplification. The 2'-O-methyl RNA molecules can subsequently hybridize with Taqman probes and initiate the second round of cyclical amplification to generate detectable fluorescence by DSN. The proposed strategy exhibits high specificity in discriminating cognate miRNAs, and the dual signal transduction process enables the detection of miRNA concentrations as low as 7.3fM. We further applied this assay to miRNA quantification in cancer cells to confirm its applicability. The present study provides a sensitive, specific and simple method for miRNA detection and holds great potential for further application in biomedical research and in the clinical laboratory.

This article presents a novel multi-mode microstrip resonator. Using the even-odd-mode method, its resonance characteristics are analyzed and the design graphs are given. Each mode equivalent circuit is a λ/4 stepped impedance resonator SIR, so the proposed resonator has a compact size and the higher harmonics can be tuned in a wide range. Stub-stub coupling is introduced to split two identical modes and produce two transmission zeros TZs. Then a tri-band filter operating at 1.5, 2.4, and 3.8 GHz is designed using the proposed resonator. The three center frequencies and bandwidths can be independently controlled. By tuning the impedance and length ratios of the stubs, wide upper stopband is achieved. Finally, the designed filter is fabricated and measured, and the measured results agree well with the simulated ones. © 2016 Wiley Periodicals, Inc. Int J RF and Microwave CAE 26:559-564, 2016.

The infection with high-risk human papillomavirus is linked to cervical cancer, nevertheless, the role of miRNAs regulated by HPV oncogenes in cancer progression remain largely unknown. Here, we knocked down endogenous E6/E7 in HPV16-positive CaSki cell lines, screened differences in miRNA expression profile with control using miRNA array. 38 miRNAs were down-regulated and 6 miRNAs were up-regulated in the E6/E7 silenced CaSki cells (>2-fold changes with P

The awareness of occupational health risk management in the electronics industry is weak in China, and many Chinese occupational health management regulations have not been effectively implemented. China&rsquo, s current occupational hazards classification method and the Environmental Protection Agency (EPA) inhalation risk assessment model recognized internationally were used to perform health risk assessments for a chip manufacturing company in the electronics industry in order to determine the existing problems and put forward the optimization proposals of the occupational hazards classification method in China. The results showed that the detected concentrations of toxic and harmful chemicals in all testing points did not exceed the occupational health exposure limits in China. According to the EPA inhalation risk assessment model, the highest values of non-carcinogenic risks of ammonia, chlorine, fluoride, sulfuric acid, hydrogen chloride, ethylene glycol, phosphine, boron trifluoride, isopropanol, benzene, and xylene were 5.10, 67.12, 1.71, 45.98, 1.83, 1.43, 160.35, 46.56, 2.52, 5.55, and 5.37, respectively, which means workers in electronic chip manufacturing companies exposed to these chemicals have higher occupational health risks. However, on the basis of the occupational hazards classification method, the occupational health risks of exposure to the toxic and hazardous chemicals are relatively harmless operations. The evaluation results of the EPA inhalation risk assessment model are generally higher than those of the occupational hazards classification method. It&rsquo, s recommended to refine the value of occupational exposure limit B, taking more characteristics of the hazard factors into account and fuzzifying the parameters to optimize the occupational hazards classification method. At the same time, it is suggested that the electronic chip manufacturing company should conduct anti-virus risk management covering in three aspects: increasing the awareness of occupational hazards, enhancing system ventilation, and improving personal health management measures.

Cross-species transmission of viruses from wildlife animal reservoirs poses a marked threat to human and animal health1. Bats have been recognized as one of the most important reservoirs for emerging viruses and the transmission of a coronavirus that originated in bats to humans via intermediate hosts was responsible for the high-impact emerging zoonosis, severe acute respiratory syndrome (SARS)2–10. Here we provide virological, epidemiological, evolutionary and experimental evidence that a novel HKU2-related bat coronavirus, swine acute diarrhoea syndrome coronavirus (SADS-CoV), is the aetiological agent that was responsible for a large-scale outbreak of fatal disease in pigs in China that has caused the death of 24,693 piglets across four farms. Notably, the outbreak began in Guangdong province in the vicinity of the origin of the SARS pandemic. Furthermore, we identified SADS-related CoVs with 96–98% sequence identity in 9.8% (58 out of 591) of anal swabs collected from bats in Guangdong province during 2013–2016, predominantly in horseshoe bats (Rhinolophus spp.) that are known reservoirs of SARS-related CoVs. We found that there were striking similarities between the SADS and SARS outbreaks in geographical, temporal, ecological and aetiological settings. This study highlights the importance of identifying coronavirus diversity and distribution in bats to mitigate future outbreaks that could threaten livestock, public health and economic growth., Analysis of viral samples from deceased piglets shows that a bat coronavirus was responsible for an outbreak of fatal disease in China and highlights the importance of the identification of coronavirus diversity and distribution in bats in order to mitigate future outbreaks of disease.

Summary Swine acute diarrhoea syndrome coronavirus (SADS‐CoV), a novel coronavirus, was first discovered in southern China in January 2017 and caused a large scale outbreak of fatal diarrheal disease in piglets. Here, we conducted a retrospective investigation of 236 samples from 45 swine farms with a clinical history of diarrheal disease to evaluate the emergence and the distribution of SADS‐CoV in pigs in China. Our results suggest that SADS‐CoV has emerged in China at least since August 2016. Meanwhile, we detected a prevalence of SADS‐CoV (43.53%), porcine deltacoronavirus (8.83%), porcine epidemic diarrhoea virus (PEDV) (78.25%), rotavirus (21.77%), and transmissible gastroenteritis virus (0%), and we also found the co‐infection of SADS‐CoV and PEDV occurred most frequently with the rate of 17.65%. We screened and obtained two new complete genomes, five N and five S genes of SADS‐CoV. Phylogenetic analysis based on these sequences revealed that all SADS‐CoV sequences in this study clustered with previously reported SADS‐CoV strains to form a well defined branch that grouped with the bat coronavirus HKU2 strains. This study is the first retrospective investigation for SADS‐CoV and provides the epidemiological information of this new virus in China, which highlights the urgency to develop effective measures to control SADS‐CoV.

MicroRNAs (miRNAs) are novel regulatory factors that play important roles in numerous cellular processes through the posttranscriptional regulation of gene expression. Recently, deregulation of the miRNA-mediated mechanism has emerged as an important pathological factor in osteoporosis. However, a detailed molecular mechanism between miRNAs and osteoporosis is still not available. In this review, the roles of miRNAs in the regulation of cells related to bone homeostasis as well as miRNAs that deregulate in human or animal are discussed. Moreover, the miRNAs that act as clusters in the biology of cells in the bone microenvironment and the difference of some important miRNAs for bone homeostasis between bone and other organs are mentioned. Overall, miRNAs that contribute to the pathogenesis of osteoporosis and their therapeutic potential are considered.

We report here the amplification and sequence analysis of two complete genomes of newly emerged porcine deltacoronavirus (PDCoV) strains, isolated from diarrhea samples from piglets in Guangdong Province in southern China. These genomes provide further sequence data for evaluating the relationships among PDCoVs from different countries.

Background. Most studies report that the common position of cervical spinal manipulation (CSM) for treating symptomatic cervical disc herniation (CDH) is lateral bending to the herniated side. However, the rationality of lateral bending position on performing CSM for CDH is still unclear. Objective. The purpose of this study is to investigate the biomechanical effects of lateral bending position on performing CSM for CDH. Methods. A finite element (FE) model of CDH (herniated on the left side) was generated in C5-6 segment based on the normal FE model. The FE model performed CSM in left lateral bending position, neutral position, and right lateral bending position, respectively. Cervical disc displacement, annulus fiber stress, and facet joint stress were observed during the simulation of CSM. Results. The cervical disc displacement on herniated side moved forward during CSM, and the maximum forward displacements were 0.23, 0.36, and 0.45 mm in left lateral bending position, neutral position, and right lateral bending position, respectively. As the same trend of cervical disc displacement, the annulus fiber stresses on herniated side from small to large were 7.40, 16.39, and 22.75 MPa in left lateral bending position, neutral position, and right lateral bending position, respectively. However, the maximum facet stresses at left superior cartilage of C6 in left lateral bending position, neutral position, and right lateral bending position were 6.88, 3.60, and 0.12 MPa, respectively. Conclusion. Compared with neutral position and right lateral bending position, though the forward displacement of cervical disc on herniated side was smaller in left lateral bending position, the annulus fiber stress on herniated side was declined by sharing load on the left facet joint. The results suggested that lateral bending to the herniated side on performing CSM tends to protect the cervical disc on herniated side. Future clinical studies are needed to verify that.