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3. Combining Intravenous Thrombolysis and Dual Antiplatelet Treatment in Patients With Minor Ischemic Stroke: A Propensity Matched Analysis of the READAPT Study Cohort

Author

Raffaele Ornello, Matteo Foschi, Federico De Santis, Michele Romoli, Tiziana Tassinari, Valentina Saia, Silvia Cenciarelli, Chiara Bedetti, Chiara Padiglioni, Bruno Censori, Valentina Puglisi, Luisa Vinciguerra, Maria Guarino, Valentina Barone, Marialuisa Zedde, Ilaria Grisendi, Marina Diomedi, Maria Rosaria Bagnato, Marco Petruzzellis, Domenico Maria Mezzapesa, Pietro Di Viesti, Vincenzo Inchingolo, Manuel Cappellari, Cecilia Zivelonghi, Paolo Candelaresi, Vincenzo Andreone, Giuseppe Rinaldi, Alessandra Bavaro, Anna Cavallini, Stefan Moraru, Pietro Querzani, Valeria Terruso, Marina Mannino, Alessandro Pezzini, Giovanni Frisullo, Francesco Muscia, Maurizio Paciaroni, Maria Giulia Mosconi, Andrea Zini, Ruggiero Leone, Carmela Palmieri, Letizia Maria Cupini, Michela Marcon, Rossana Tassi, Enzo Sanzaro, Cristina Paci, Giovanna Viticchi, Daniele Orsucci, Anne Falcou, Simone Beretta, Roberto Tarletti, Patrizia Nencini, Eugenia Rota, Federica Nicoletta Sepe, Delfina Ferrandi, Luigi Caputi, Gino Volpi, Salvatore La Spada, Mario Beccia, Claudia Rinaldi, Vincenzo Mastrangelo, Francesco Di Blasio, Paolo Invernizzi, Giuseppe Pelliccioni, Maria Vittoria De Angelis, Laura Bonanni, Giampietro Ruzza, Emanuele Alessandro Caggia, Monia Russo, Agnese Tonon, Maria Cristina Acciarri, Sabrina Anticoli, Cinzia Roberti, Giovanni Manobianca, Gaspare Scaglione, Francesca Pistoia, Alberto Fortini, Antonella De Boni, Alessandra Sanna, Alberto Chiti, Leonardo Barbarini, Marcella Caggiula, Maela Masato, Massimo Del Sette, Francesco Passarelli, Maria Roberta Bongioanni, Danilo Toni, Stefano Ricci, Eleonora De Matteis, and Simona Sacco

Subjects
dual antiplatelet treatment, functional outcome, intravenous thrombolysis, ischemic stroke, real world, safety, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Background The optimal treatment for acute minor ischemic stroke is still undefined. and options include dual antiplatelet treatment (DAPT), intravenous thrombolysis (IVT), or their combination. We aimed to investigate benefits and risks of combining IVT and DAPT versus DAPT alone in patients with MIS. Methods and Results This is a prespecified propensity score‐matched analysis from a prospective multicentric real‐world study (READAPT [Real‐Life Study on Short‐Term Dual Antiplatelet Treatment in Patients With Ischemic Stroke or Transient Ischemic Attack]). We included patients with MIS (National Institutes of Health Stroke Scale score at admission ≤5), without prestroke disability (modified Rankin scale [mRS] score ≤2). The primary outcomes were 90‐day mRS score of 0 to 2 and ordinal mRS distribution. The secondary outcomes included 90‐day risk of stroke and other vascular events and 24‐hour early neurological improvement or deterioration (≥2‐point National Institutes of Health Stroke Scale score decrease or increase from the baseline, respectively). From 1373 patients with MIS, 240 patients treated with IVT plus DAPT were matched with 427 patients treated with DAPT alone. At 90 days, IVT plus DAPT versus DAPT alone showed similar frequency of mRS 0 to 2 (risk difference, 2.3% [95% CI −2.0% to 6.7%]; P=0.295; risk ratio, 1.03 [95% CI 0.98–1.08]; P=0.312) but more favorable ordinal mRS scores distribution (odds ratio, 0.57 [95% CI 0.41–0.79]; P

Published
2024
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4. Septin-5 and -7-IgGs: Neurologic, Serologic, and Pathophysiologic Characteristics.

Author

Hinson, Shannon, Honorat, Josephe, Grund, Ethan, Clarkson, Benjamin, Miske, Ramona, Scharf, Madeleine, Zivelonghi, Cecilia, Al-Lozi, Muhammad, Bucelli, Robert, Budhram, Adrian, Cho, Tracey, Choi, Ellie, Grell, Jacquelyn, Lopez-Chiriboga, Alfonso, Levin, Marc, Merati, Melody, Montalvo, Mayra, Pittock, Sean, Wilson, Michael, Howe, Charles, and McKeon, Andrew

Subjects
Animals, Rats, Mice, Septins, Autoimmunity, Neurons, Brain Diseases, Immunoglobulin G, Spinal Cord Diseases
Abstract

BACKGROUND AND OBJECTIVES: We sought to determine clinical significance of neuronal septin autoimmunity and evaluate for potential IgG effects. METHODS: Septin-IgGs were detected by indirect immunofluorescence assays (IFAs; mouse tissue and cell based) or Western blot. IgG binding to (and internalization of) extracellular septin epitopes were evaluated for by live rat hippocampal neuron assay. The impact of purified patient IgGs on murine cortical neuron function was determined by recording extracellular field potentials in a multielectrode array platform. RESULTS: Septin-IgGs were identified in 23 patients. All 8 patients with septin-5-IgG detected had cerebellar ataxia, and 7 had prominent eye movement disorders. One of 2 patients with co-existing septin-7-IgG had additional psychiatric phenotype (apathy, emotional blunting, and poor insight). Fifteen patients had septin-7 autoimmunity, without septin-5-IgG detected. Disorders included encephalopathy (11; 2 patients with accompanying myelopathy, and 2 were relapsing), myelopathy (3), and episodic ataxia (1). Psychiatric symptoms (≥1 of agitation, apathy, catatonia, disorganized thinking, and paranoia) were prominent in 6 of 11 patients with encephalopathic symptoms. Eight of 10 patients with data available (from 23 total) improved after immunotherapy, and a further 2 patients improved spontaneously. Staining of plasma membranes of live hippocampal neurons produced by patient IgGs (subclasses 1 and 2) colocalized with pre- and post-synaptic markers. Decreased spiking and bursting behavior in mixed cultures of murine glutamatergic and GABAergic cortical neurons produced by patient IgGs were attributable to neither antigenic crosslinking and internalization nor complement activation. INTERPRETATION: Septin-IgGs are predictive of distinct treatment-responsive autoimmune central nervous system (CNS) disorders. Live neuron binding and induced electrophysiologic effects by patient IgGs may support septin-specific pathophysiology. ANN NEUROL 2022;92:1090-1101.

Published
2022

5. Impact of Postprocedural Graft Flow on Outcomes Following Chronic Total Occlusion Intervention in Postcoronary Artery Bypass Graft Patients: A Detailed Angiographic Analysis

Author

Poletti, Enrico, Dens, Jo, Egred, Mohaned, Munafò, Andrea Raffaele, Castaldi, Gianluca, De Cock, Emmanuel, Jossart, Adrien, Poels, Ella, Khandaker, Azizul Hasan, Lesizza, Pierluigi, Zivelonghi, Carlo, Scott, Benjamin, Haine, Steven Els Frans, Kayaert, Peter, Bataille, Yoann, Cornelis, Kristoff, Saad, Georges, Coussement, Patrick, Bennett, Johan, Droogmans, Steven, Oreglia, Jacopo, Ungureanu, Claudiu, Iqbal, M Bilal, and Agostoni, Pierfrancesco

Published
2024
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6. Mechanical thrombectomy in patients with heart failure: the Italian registry of Endovascular Treatment in Acute Stroke

Author

Gentile, Luana, Pracucci, Giovanni, Saia, Valentina, Falcou, Anne, Biraschi, Francesco, Zini, Andrea, Simonetti, Luigi, Riva, Letizia, Bigliardi, Guido, Vallone, Stefano, Nencini, Patrizia, Limbucci, Nicola, Diomedi, Marina, Da Ros, Valerio, Longoni, Marco, Ruggiero, Maria, Tassinari, Tiziana, Allegretti, Luca, Cerrato, Paolo, Rubino, Elisa, Bergui, Mauro, Cavallo, Roberto, Naldi, Andrea, Comelli, Chiara, Cappellari, Manuel, Zivelonghi, Cecilia, Plebani, Mauro, De Vito, Alessandro, Merli, Nicola, Saletti, Andrea, Musolino, Rosa Fortunata, Ferraù, Ludovica, Vinci, Sergio Lucio, Sacco, Simona, Orlandi, Berardino, De Santis, Federica, Filauri, Pietro, Ruiz, Luigi, Sepe, Federica Nicoletta, Gallesio, Ivan, Petruzzellis, Marco, Chiumarulo, Luigi, Sangalli, Davide, Salmaggi, Andrea, Filizzolo, Marco, Moller, Jessica, Melis, Maurizio, Comelli, Simone, Magoni, Mauro, Gilberti, Nicola, Gasparotti, Roberto, Invernizzi, Paolo, Pavia, Marco, Pinto, Vincenza, Laspada, Salvatore, Marcheselli, Simona, Ajello, Daniele, Viaro, Federica, Baracchini, Claudio, Causin, Francesco, Giannini, Nicola, Caselli, Maria Chiara, Mancuso, Michelangelo, Cosottini, Mirco, Scoditti, Umberto, Menozzi, Roberto, Russo, Monia, Amistá, Pietro, Napoletano, Rosa, Romano, Daniele Giuseppe, Tassi, Rossana, Bracco, Sandra, Carimati, Federico, Versino, Maurizio, Giorgianni, Andrea, De Boni, Antonella, Fasano, Antonio, Barbarini, Leonardo, Paladini, Adriana, Franchini, Enrica, Dall’Ora, Elisa, Comai, Alessio, Giovanni, Frisullo, Pedicelli, Alessandro, Sallustio, Fabrizio, Casetta, Ilaria, Fainardi, Enrico, Mangiafico, Salvatore, and Toni, Danilo

Published
2023
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7. SARS-CoV-2 antibodies in inflammatory neurological conditions: a multicentre retrospective comparative study

Author

Zivelonghi, Cecilia, Dinoto, Alessandro, Irani, Sarosh R., McKeon, Andrew, Pilotto, Andrea, Padovani, Alessandro, Masciocchi, Stefano, Magni, Eugenio, Mancinelli, Chiara R., Capra, Ruggero, Maniscalco, Giorgia T., Volonghi, Irene, Easton, Ava, Alberti, Daniela, Zanusso, Gianluigi, Monaco, Salvatore, Salvagno, Gian Luca, Lippi, Giuseppe, Ferrari, Sergio, and Mariotto, Sara

Published
2023
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9. The Belgian Registry on Coronary Function Testing (BELmicro Registry): Study Population, Prevalence of Coronary Vascular Dysfunction, and Procedural Safety

Author

Bringmans, Tijs, Benedetti, Alice, Zivelonghi, Carlo, Vanhaverbeke, Maarten, Mathieu, Frédéric Daniel, Palmers, Pieter-Jan, Coussement, Patrick, De Wilder, Kenneth, Everaert, Bert, Coeman, Mathieu, Demeure, Fabian, Kersemans, Maarten, Bortone, Carlos Collet, Kayaert, Peter, Van Mieghem, Carlos, and Segers, Vincent Frans Maria

Published
2024
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10. Defining short-term outcomes of minor ischemic stroke due to small artery occlusion in the era of dual antiplatelet treatment: A READAPT study sub-analysis

Author

Foschi, Matteo, De Matteis, Eleonora, De Santis, Federico, Romoli, Michele, Tassinari, Tiziana, Saia, Valentina, Cenciarelli, Silvia, Bedetti, Chiara, Padiglioni, Chiara, Censori, Bruno, Puglisi, Valentina, Vinciguerra, Luisa, Guarino, Maria, Barone, Valentina, Zedde, Marialuisa, Grisendi, Ilaria, Diomedi, Marina, Bagnato, Maria Rosaria, Petruzzellis, Marco, Mezzapesa, Domenico Maria, Di Viesti, Pietro, Inchingolo, Vincenzo, Cappellari, Manuel, Zivelonghi, Cecilia, Candelaresi, Paolo, Andreone, Vincenzo, Rinaldi, Giuseppe, Bavaro, Alessandra, Cavallini, Anna, Moraru, Stefan, Querzani, Pietro, Terruso, Valeria, Mannino, Marina, Pezzini, Alessandro, Frisullo, Giovanni, Muscia, Francesco, Paciaroni, Maurizio, Mosconi, Maria Giulia, Zini, Andrea, Leone, Ruggiero, Palmieri, Carmela, Cupini, Letizia Maria, Marcon, Michela, Tassi, Rossana, Sanzaro, Enzo, Paci, Cristina, Viticchi, Giovanna, Orsucci, Daniele, Falcou, Anne, Diamanti, Susanna, Tarletti, Roberto, Nencini, Patrizia, Rota, Eugenia, Sepe, Federica Nicoletta, Ferrandi, Delfina, Caputi, Luigi, Volpi, Gino, La Spada, Salvatore, Beccia, Mario, Rinaldi, Claudia, Mastrangelo, Vincenzo, Di Blasio, Francesco, Invernizzi, Paolo, Pelliccioni, Giuseppe, De Angelis, Maria Vittoria, Bonanni, Laura, Ruzza, Giampietro, Caggia, Emanuele Alessandro, Russo, Monia, Tonon, Agnese, Acciarri, Maria Cristina, Anticoli, Sabrina, Roberti, Cinzia, Manobianca, Giovanni, Scaglione, Gaspare, Pistoia, Francesca, Fortini, Alberto, De Boni, Antonella, Sanna, Alessandra, Chiti, Alberto, Barbarini, Leonardo, Caggiula, Marcella, Masato, Maela, Del Sette, Massimo, Passarelli, Francesco, Bongioanni, Maria Roberta, Toni, Danilo, Ricci, Stefano, Sacco, Simona, and Ornello, Raffaele

Published
2024
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11. Prosthesis Infolding Incidence and Short-Term Outcomes in Transcatheter Aortic Valve Implantation Using Evolut Self-Expandable Device: A Multicenter Study

Author

Bezzeccheri, Andrea, Poletti, Enrico, Vermeersch, Paul, Veulemans, Verena, Piuhola, Jarkko, Kerkelä, Seija, Lehtola, Heidi, De Backer, Ole, Quagliana, Angelo, Mammone, Concetta, Ribichini, Flavio, Prihadi, Edgard, Scott, Benjamin, Zivelonghi, Carlo, Verheye, Stefan, and Agostoni, Pierfrancesco

Published
2024
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12. Re-irradiation for recurrent intracranial meningiomas: Analysis of clinical outcomes and prognostic factors

Author

Desideri, Isacco, Morelli, Ilaria, Banini, Marco, Greto, Daniela, Visani, Luca, Nozzoli, Filippo, Caini, Saverio, Della Puppa, Alessandro, Livi, Lorenzo, Perini, Zeno, Zivelonghi, Emanuele, Bulgarelli, Giorgia, Pinzi, Valentina, Navarria, Pierina, Clerici, Elena, Scorsetti, Marta, Ascolese, Anna Maria, Osti, Mattia Falchetto, Anselmo, Paola, Amelio, Dante, Minniti, Giuseppe, and Scartoni, Daniele

Published
2024
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13. Magnetic resonance-guided focused ultrasound unilateral thalamotomy for medically refractory essential tremor: 3-year follow-up data

Author

Stefano Tamburin, Fabio Paio, Tommaso Bovi, Giorgia Bulgarelli, Michele Longhi, Roberto Foroni, Elisa Mantovani, Paolo Maria Polloniato, Micaela Tagliamonte, Emanuele Zivelonghi, Chiara Zucchella, Carlo Cavedon, Antonio Nicolato, Benedetto Petralia, Francesco Sala, Bruno Bonetti, Michele Tinazzi, Stefania Montemezzi, and Giuseppe Kenneth Ricciardi

Subjects
functional neurosurgery, MRgFUS, non-invasive, thalamus, thalamotomy, tremor, Neurology. Diseases of the nervous system, RC346-429
Abstract

IntroductionMagnetic resonance–guided focused ultrasound (MRgFUS) thalamotomy of the ventralis intermediate (Vim) nucleus is an “incisionless” treatment for medically refractory essential tremor (ET). We present data on 49 consecutive cases of MRgFUS Vim thalamotomy followed-up for 3 years and review the literature on studies with longer follow-up data.MethodsA retrospective chart review of patients who underwent MRgFUS thalamotomy (January 2018–December 2020) at our institution was performed. Clinical Rating Scale for Tremor (CRST) and Quality of Life in Essential Tremor (QUEST) scores were obtained pre-operatively and at each follow-up with an assessment of side effects. Patients had post-operative magnetic resonance imaging within 24 h and at 1 month to figure out lesion location, size, and extent. The results of studies with follow-up ≥3 years were summarized through a literature review.ResultsThe CRST total (baseline: 58.6 ± 17.1, 3-year: 40.8 ± 18.0) and subscale scores (A + B, baseline: 23.5 ± 6.3, 3-year: 12.8 ± 7.9; C, baseline: 12.7 ± 4.3, 3-year: 5.8 ± 3.9) and the QUEST score (baseline: 38.0 ± 14.8, 3-year: 18.7 ± 13.3) showed significant improvement that was stable during the 3-year follow-up. Three patients reported tremor recurrence and two were satisfactorily retreated. Side effects were reported by 44% of patients (severe: 4%, mild and transient: 40%). The improvement in tremor and quality of life in our cohort was consistent with the literature.ConclusionWe confirmed the effectiveness and safety of MRgFUS Vim thalamotomy in medically refractory ET up to 3 years.

Published
2024
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14. Minimalistic Hybrid Approach for the Percutaneous Treatment of Coronary Chronic Total Occlusions: Midterm Follow-Up of an International Multicenter Cohort

Author

Castaldi, Gianluca, Kovacic, Mihajlo, Poletti, Enrico, Benedetti, Alice, Moroni, Alice, Scott, Benjamin, Wilgenhof, Adriaan, Bezzeccheri, Andrea, Vescovo, Giovanni, Budassi, Simone, El Jattari, Hicham, Convens, Carl, Verheye, Stefan, Vermeersch, Paul, Zivelonghi, Carlo, Tumscitz, Carlo, and Agostoni, Pierfrancesco

Published
2024
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19. Less bleeding by omitting aspirin in non-ST-segment elevation acute coronary syndrome patients: Rationale and design of the LEGACY study

Author

van der Sangen, Niels M.R., Küçük, I. Tarik, Sivanesan, Shabiga, Appelman, Yolande, ten Berg, Jurriën M., Verburg, Ashley, Azzahhafi, Jaouad, Arkenbout, E. Karin, Kikkert, Wouter J., Pisters, Ron, Jukema, J. Wouter, Arslan, Fatih, van ‘t Hof, Arnoud, Ilhan, Mustafa, Hoebers, Loes P., van der Schaaf, René J., Damman, Peter, Woudstra, Pier, van de Hoef, Tim P., Bax, Matthijs, Anthonio, Rutger L., Polad, Jawed, Adriaenssens, Tom, Dewilde, Willem, Zivelonghi, Carlo, Laanmets, Peep, Majas, Risko, Dijkgraaf, Marcel G.W., Claessen, Bimmer E.P.M., and Henriques, José P.S.

Published
2023
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20. Effect of Asymptomatic and Symptomatic COVID-19 on Acute Ischemic Stroke Revascularization Outcomes

Author

Strambo, Davide, Marto, João Pedro, Ntaios, George, Nguyen, Thanh N., Michel, Patrik, Herzig, Roman, Członkowksa, Anna, Demeestere, Jelle, Yassin Mansour, Ossama, Georgiopoulos, Georgios, Nogueira, Raul G., Salerno, Alexander, Wegener, Susanne, Baumgartner, Philipp, Cereda, Carlo W., Bianco, Giovanni, Beyeler, Morin, Arnold, Marcel, Carrera, Emmanuel, Machi, Paolo, Altersberger, Valerian, Bonati, Leo, Gensicke, Henrik, Bolognese, Manuel, Peters, Nils, Wetzel, Stephan, Magriço, Marta, Nuno Ramos, João, Sargento-Freitas, João, Machado, Rita, Maia, Carolina, Machado, Egídio, Paiva-Nunes, Ana, Ferreira, Patrícia, Pinho-e-Melo, Teresa, Carvalho-Dias, Mariana, Paula, André, Alberto Correia, Manuel, Castro, Pedro, Azevedo, Elsa, Albuquerque, Luís, Nuno-Alves, José, Ferreira-Pinto, Joana, Meira, Torcato, Pereira, Liliana, Rodrigues, Miguel, Araújo, André, Rodrigues, Marta, Rocha, Mariana, Pereira-Fonseca, Ângelo, Ribeiro, Luís, Varela, Ricardo, Cappellari, Manuel, Zivelonghi, Cecilia, Sajeva, Giulia, Zini, Andrea, Gentile, Mauro, Forlivesi, Stefano, Migliaccio, Ludovica, Sessa, Maria, Pezzini, Alessandro, Sangalli, Davide, Zedde, Marialuisa, Pascarella, Rosario, Diamanti, Susanna, Beretta, Simone, Schwarz, Ghil, Frisullo, Giovanni, Marcheselli, Simona, Seners, Pierre, Sabben, Candice, Escalard, Simon, Piotin, Michel, Maier, Benjamin, Charbonnier, Guillaume, Vuillier, Fabrice, Legris, Loic, Cuisenier, Pauline, Vodret, Francesca R., Marnat, Gaultier, Liegey, Jean-Sebastien, Sibon, Igor, Flottmann, Fabian, Broocks, Gabriel, Gloyer, Nils-Ole, Bohmann, Ferdinand O., Hendrik Schaefer, Jan, Nolte, Christian H., Audebert, Heinrich, Siebert, Eberhard, Sykora, Marek, Lang, Wilfried, Ferrari, Julia, Mayer-Suess, Lukas, Knoflach, Michael, Gizewski, Elke-Ruth, Stolp, Jeffrey, Stolze, Lotte J., Coutinho, Jonathan M., Nederkoorn, Paul J., van-den-Wijngaard, Ido, de Meris, Joke, Lemmens, Robin, De Raedt, Sylvie, Vandervorst, Fenne, Pierre Rutgers, Matthieu, Guilmot, Antoine, Dusart, Anne, Bellante, Flavio, Calleja-Castaño, Patricia, Ostos, Fernando, Gonzalez-Ortega, Guillermo, Martín-Jiménez, Paloma, García-Madrona, Sebastian, Cruz-Culebras, Antonio, Vera, Rocio, Matute, Maria-Consuelo, Fuentes, Blanca, Alonso-de-Leciñana, María, Rigual, Ricardo, Díez-Tejedor, Exuperio, Pérez-Sánchez, Soledad, Montaner, Joan, Díaz-Otero, Fernando, Perez de la Ossa, Natalia, Flores-Pina, Belén, Muñoz-Narbona, Lucia, Chamorro, Angel, Rodríguez-Vázquez, Alejandro, Renú, Arturo, Ayo-Martin, Oscar, Hernandez-Fernandez, Francisco, Segura, Tomas, Tejada-Meza, Herbert, Hlaing, Thant, See, Isaiah, Simister, Robert, Werring, David J., Saxhaug Kristoffersen, Espen, Nordanstig, Annika, Jood, Katarina, Rentzos, Alexandros, Šimůnek, Libor, Krajíčková, Dagmar, Krajina, Antonín, Mikulík, Robert, Cviková, Martina, Vinklárek, Jan, Školoudík, David, Roubec, Martin, Hurtikova, Eva, Hrubý, Rostislav, Ostry, Svatopluk, Skoda, Ondrej, Pernicka, Marek, Kočí, Lubomír, Eichlová, Zuzana, Jíra, Martin, Kovář, Martin, Panský, Michal, Mencl, Pavel, Paloušková, Hana, Tomek, Aleš, Janský, Petr, Olšerová, Anna, Šrámek, Martin, Havlíček, Roman, Malý, Petr, Trakal, Lukáš, Fiksa, Jan, Slovák, Matěj, Karliński, Michał, Nowak, Maciej, Sienkiewicz-Jarosz, Halina, Bochynska, Anna, Wrona, Pawel, Homa, Tomasz, Sawczynska, Katarzyna, Slowik, Agnieszka, Wlodarczyk, Ewa, Wiącek, Marcin, Tomaszewska-Lampart, Izabella, Sieczkowski, Bartosz, Bartosik-Psujek, Halina, Bilik, Marta, Bandzarewicz, Anna, Dorobek, Malgorzata, Zielińska-Turek, Justyna, Nowakowska-Kotas, Marta, Obara, Krystian, Urbanowski, Paweł, Budrewicz, Sławomir, Guziński, Maciej, Świtońska, Milena, Rutkowska, Iwona, Sobieszak-Skura, Paulina, Łabuz-Roszak, Beata, Dębiec, Aleksander, Staszewski, Jacek, Stępień, Adam, Zwiernik, Jacek, Wasilewski, Grzegorz, Tiu, Cristina, Terecoasă, Elena-Oana, Radu, Razvan-Alexandru, Negrila, Anca, Dorobat, Bogdan, Panea, Cristina, Tiu, Vlad, Petrescu, Simona, Özcan-Özdemir, Atilla, Mahmoud, Mostafa, El-Samahy, Hussam, Abdelkhalek, Hazem, Al-Hashel, Jasem, Ibrahim Ismail, Ismail, Salmeen, Athari, Ghoreishi, Abdoreza, Sabetay, Sergiu, Gross, Hana, Klein, Piers, Abdalkader, Mohamad, Jabbour, Pascal, El Naamani, Kareem, Tjoumakaris, Stavropoula, Abbas, Rawad, Mohamed, Ghada-A., Chebl, Alex, Min, Jiangyong, Hovingh, Majesta, Tsai, Jenny, Khan, Muhib-A., Nalleballe, Krishna, Onteddu, Sanjeeva, Masoud, Hesham E., Michael, Mina, Kaur, Navreet, Maali, Laith, Abraham, Michael, Khandelwal, Priyank, Bach, Ivo, Ong, Melody, Babici, Denis, Khawaja, Ayaz-M., Hakemi, Maryam, Rajamani, Kumar, Cano-Nigenda, Vanessa, Arauz, Antonio, Amaya, Pablo, Llanos, Natalia, Arango, Akemi, Vences, Miguel A., Barrientos, José-Domingo, Caetano, Rayllene, Targa, Rodrigo, Scollo, Sergio, Yalung, Patrick, Nagendra, Shashank, Gaikwad, Abhijit, and Seo, Kwon-Duk

Published
2024
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25. Association of the careggi collateral score with radiological outcomes after thrombectomy for stroke with an occlusion of the middle cerebral artery

Author

Cappellari, Manuel, Saia, Valentina, Pracucci, Giovanni, Fainardi, Enrico, Nencini, Patrizia, Malfatto, Laura, Tassi, Rossana, Cerrato, Paolo, Mancuso, Michelangelo, Pesare, Angela, La Spina, Paolino, Lotti, Enrico Maria, Casalena, Alfonsina, Petruzzellis, Marco, Baracchini, Claudio, Via, Alessandra Giai, Gaudiano, Carmen, Sallustio, Fabrizio, Tassinari, Tiziana, Critelli, Adriana, Melis, Maurizio, Persico, Alessandra, Casetta, Ilaria, Sacco, Simona, Ferrandi, Delfina, Marcheselli, Simona, Russo, Monia, Zivelonghi, Cecilia, Mandruzzato, Nicolò, Invernizzi, Paolo, Romano, Daniele, Nicolini, Ettore, Scoditti, Umberto, Magoni, Mauro, Cariddi, Lucia Princiotta, Vallone, Stefano, Inzitari, Domenico, Toni, Danilo, and Mangiafico, Salavatore

Published
2022
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26. Early atrial fibrillation detection is associated with higher arrhythmic burden in patients with loop recorder after an embolic stroke of undetermined source

Author

Sofia Capocci, Luca Tomasi, Cecilia Zivelonghi, Bruna Bolzan, Giampaolo Berton, Mattia Strazzanti, Elena Franchi, Ruggero Tomei, Francesca Vassanelli, Manuel Cappellari, Flavio Luciano Ribichini, and Giacomo Mugnai

Subjects
Stroke, Atrial fibrillation, Burden, Early detection, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Background: After an embolic stroke of undetermined source (ESUS), long-term monitoring is recommended to start an anticoagulation therapy in patients with documented atrial fibrillation (AF). Literature is sparse about the AF burden following an ESUS, although this might have significant implications in terms of clinical management and therapeutic strategy. Our primary aim was to evaluate a possible association between early detection of AF (within 90 days from the ILR implantation) and higher AF burden. Methods: This is a retrospective single-center study of 129 consecutive patients who received implantable loop recorders (ILRs) after an ESUS for detection of subclinical AF and their AF burden. Results: Mean age was 70.3 ± 10.4 years old (males: 51.9%). Atrial fibrillation was found in 40.3% of patients. Patients with AF were older, presented a higher CHAD2S2-Vasc Score and greater left atrial volume compared with patients without AF. The median AF burden was 1.2%; 59% of patients had the first AF episode within 90 days from the ILR implant while 41% experienced the first episode later than 90 days. The AF burden was significantly higher in the former group. Of note, the univariate analysis showed that only early AF detection was significantly associated with AF burden >1% (OR 20.0; 95% CI 1.68–238.6, p = 0.01). Conclusions: The early AF detection was found to be significantly associated with a higher burden of AF.

Published
2023
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27. Response to Tugcu et al

Author

Desideri, Isacco, primary, Morelli, Ilaria, additional, Banini, Marco, additional, Greto, Daniela, additional, Visani, Luca, additional, Nozzoli, Filippo, additional, Caini, Saverio, additional, Della Puppa, Alessandro, additional, Livi, Lorenzo, additional, Perini, Zeno, additional, Zivelonghi, Emanuele, additional, Bulgarelli, Giorgia, additional, Pinzi, Valentina, additional, Navarria, Pierina, additional, Clerici, Elena, additional, Scorsetti, Marta, additional, Maria Ascolese, Anna, additional, Falchetto Osti, Mattia, additional, Anselmo, Paola, additional, Amelio, Dante, additional, Minniti, Giuseppe, additional, and Scartoni, Daniele, additional

Published
2024
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28. Heart Failure-Related Outcomes in Patients with Left Ventricular Dysfunction Undergoing Percutaneous Chronic Total Occlusion Revascularization

Author

Pierluigi Lesizza, Lennert Minten, Ella Poels, Maarten Vanhaverbeke, Gianluca Castaldi, Keir McCutcheon, Daan Cottens, Carlo Zivelonghi, Pierfrancesco Agostoni, Christophe Dubois, Jo Dens, and Johan Bennett

Subjects
cto pci, lv dysfunction, heart failure, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Background: The presence of a chronic total occlusion (CTO) and severe left ventricular (LV) systolic dysfunction are known negative prognostic factors in patients with coronary artery disease. Several studies have examined the effect of CTO revascularization on mortality, symptoms, occurrence of myocardial infarction (MI), and cardiac function in patients with normal or reduced LV function. However, the effect of CTO revascularization on heart failure-related events in patients with LV dysfunction, such as heart failure hospitalization (HFH), the occurrence of atrial fibrillation (AF), and a worsening renal function (WRF), has not yet been evaluated. To assess the success rate and safety of CTO percutaneous coronary interventions (PCIs) in coronary patients with LV ejection fractions of ≤40% and evaluate the impact of successful CTO revascularization on HFH, occurrence of AF, and WRF. Methods: Prospectively, data were collected from CTO PCIs performed at three referral centers and analyzed. From a total of 1435 CTO PCIs, 132 (9.2%) patients with a left ventricular ejection fraction (LVEF) of ≤40% were included in this analysis. The median follow-up duration was 23.18 months (interquartile range (IQR): 11.02–46.66 months). Results: A successful CTO PCI was achieved in 109 of these patients, while the procedure was unsuccessful in 23 patients (82.5% procedural success rate). Overall, the intervention had an acceptable number of peri-procedural (or in-hospital) complications (9.1%). During the follow-up period, the rates of all-cause death, cardiovascular death, and non-fatal MI were not significantly different between the two groups. The rates of HFH were significantly lower in the successful PCI group, while WRF and AF did not differ between successful and unsuccessful PCI groups. Successful PCI and higher estimated glomerular filtration rate (eGFR) were independent predictors of a lower risk of HFH, while prior stroke and diabetes were independent predictors of a higher risk of HFH. Conclusions: In patients with reduced LV systolic function (ejection fraction, EF ≤40%), CTO PCI is a safe and effective procedure and successful CTO PCI is independently associated with a lower risk of HFH during follow-up. Further expansion of this cohort is necessary to confirm these results.

Published
2023
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29. Peripheral neuropathies during the COVID-19 pandemic: is there a relation?

Author

Trentinaglia, Milena, Lippi, Giuseppe, Salvagno, Gian Luca, Rispoli, Marianna G., De Angelis, Maria Vittoria, Castellani, Francesca, Alberti, Daniela, Maniscalco, Giorgia T., Rossi, Francesca, Turri, Mara, Rossi, Patrizia, Del Zotto, Elisabetta, Fusina, Simone, Cardellini, Davide, Zivelonghi, Cecilia, Volonghi, Irene, Monaco, Salvatore, Briani, Chiara, Ferrari, Sergio, and Mariotto, Sara

Published
2022
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30. Divergence Between Clinical Trial Evidence and Actual Practice in Use of Dual Antiplatelet Therapy After Transient Ischemic Attack and Minor Stroke

Author

De Matteis, Eleonora, De Santis, Federico, Ornello, Raffaele, Censori, Bruno, Puglisi, Valentina, Vinciguerra, Luisa, Giossi, Alessia, Di Viesti, Pietro, Inchingolo, Vincenzo, Fratta, Giovanni Matteo, Diomedi, Marina, Bagnato, Maria Rosaria, Cenciarelli, Silvia, Bedetti, Chiara, Padiglioni, Chiara, Tassinari, Tiziana, Saia, Valentina, Russo, Alessandro, Petruzzellis, Marco, Mezzapesa, Domenico Maria, Caccamo, Martina, Rinaldi, Giuseppe, Bavaro, Alessandra, Paciaroni, Maurizio, Mosconi, Maria Giulia, Foschi, Matteo, Querzani, Pietro, Muscia, Francesco, Gallo Cassarino, Serena, Candelaresi, Paolo, De Mase, Antonio, Guarino, Maria, Cupini, Letizia Maria, Sanzaro, Enzo, Zini, Andrea, La Spada, Salvatore, Palmieri, Carmela, Sepe, Federica Nicoletta, Beretta, Simone, Paci, Cristina, Caggia, Emanuele Alessandro, De Angelis, Maria Vittoria, Bonanni, Laura, Volpi, Gino, Tassi, Rossana, Pistoia, Francesca, Scoditti, Umberto, Tonon, Agnese, Viticchi, Giovanna, Ruzza, Giampietro, Nencini, Patrizia, Cavallini, Anna, Toni, Danilo, Ricci, Stefano, Sacco, Simona, Acciarri, Maria Cristina, Alessi, Chiara, Angelocola, Stefania Martina, Ajdinaj, Paola, Barbarini, Leonardo, Barone, Valentina, Baruffi, Maraia Cristina, Bassi, Chiara, Beccia, Mario, Bellavia, Simone, Biscetti, Leonardo, Bonaffini, Novella, Bolamperti, Laura, Bongioanni, Maria Roberta, Brienza, Marianna, Bruzzone, Gian Luca, Cameriere, Valentina, Campagnaro, Alessandro, Cappellani, Roberto, Cappellari, Manuel, Caputi, Luigi, Cardinali, Patrizio, Coppo, Lorenzo, De Boni, Antonella, De Franco, Ivo Giuseppe, De Luca, Cristina, Diamanti, Susanna, Di Blasio, Francesco, Di Carmine, Caterina, Di Lisi, Filomena, Di Giovanni, Anna, Faini, Claudia, Ferrarese, Carlo, Fleetwood, Thomas, Fortini, Alberto, Frisullo, Giovanni, Galotto, Debora, Genovese, Antonio, Gentile, Luana, Invernizzi, Paolo, La Starza, Sara, Letteri, Federica, Manobianca, Giovanni, Mannino, Marina, Marcon, Michela, Masato, Maela, Mazzacane, Federico, Menegazzo, Elisabetta, Menichetti, Chiara, Monaco, Daniela, Naldi, Federica, Nannucci, Serena, Occhipinti, Clorinda, Orsucci, Daniele, Paolucci, Silvia, Passarelli, Francesco, Papiri, Giulio, Pelliccioni, Giuseppe, Perini, Francesco, Pinto, Vincenza, Potente, Eleonora, Puca, Emanuele, Ricciardi, Maria Chiara, Roberti, Cinzia, Romoli, Michele, Rondelli, Francesca, Rota, Eugenia, Russo, Monia, Sacchini, Elisa, Sanna, Alessandra, Scaglione, Gaspare, Scalvini, Andrea, Scala, Irene, Scarpato, Ciro, Servillo, Giovanna, Sgarlata, Eleonora, Silvestrini, Mauro, Simonetto, Marco, Spina, Emanuele, Tarletti, Roberto, Terruso, Valeria, Tocco, Pierluigi, Tudisco, Laura, Valcamonica, Gloria, Valente, Martina, Vista, Marco, Zito, Antonio, and Zivelonghi, Cecilia

Published
2023
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31. Association of the Careggi Collateral Score with 3-month modified Rankin Scale score after thrombectomy for stroke with occlusion of the middle cerebral artery

Author

Cappellari, Manuel, Saia, Valentina, Pracucci, Giovanni, Enrico, Fainardi, Consoli, Arturo, Nappini, Sergio, Castellan, Lucio, Bracco, Sandra, Bergui, Mauro, Cosottini, Mirco, Vangosa, Alessandra Briatico, Vinci, Sergio, Ruggiero, Maria, Puglielli, Edoardo, Chiumarulo, Luigi, Cester, Giacomo, Comelli, Chiara, Silvagni, Umberto, Morosetti, Daniele, Caldiera, Valentina, Cavasin, Nicola, Ledda, Valeria, Sanfilippo, Giuseppina, Saletti, Andrea, Filauri, Pietro, Gallesio, Ivan, Nuzzi, Nunzio Paolo, Amistá, Pitero, Zivelonghi, Cecilia, Plebani, Mauro, Pavia, Marco, Romano, Daniele, Biraschi, Francesco, Menozzi, Roberto, Gasparotti, Roberto, Giorgianni, Andrea, Zini, Andrea, Inzitari, Domenico, Toni, Danilo, and Mangiafico, Salvatore

Published
2022
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33. Mutable Collagenous Tissue Isolated from Echinoderms Leads to the Production of a Dermal Template That Is Biocompatible and Effective for Wound Healing in Rats

Author

Anna Carolo, Luca Melotti, Giulia Zivelonghi, Roberta Sacchetto, Eylem Emek Akyürek, Tiziana Martinello, Andrea Venerando, Ilaria Iacopetti, Michela Sugni, Giordana Martinelli, Margherita Roncoroni, Stefania Marzorati, Silvia Barbon, Martina Contran, Damiana Incendi, Filippo Perozzo, Andrea Porzionato, Vincenzo Vindigni, and Marco Patruno

Subjects
wound healing, marine collagen, mutable collagenous tissue, circular economy, blue biotechnologies, skin regeneration, Biology (General), QH301-705.5
Abstract

The mutable collagenous tissue (MCT) of echinoderms possesses biological peculiarities that facilitate native collagen extraction and employment for biomedical applications such as regenerative purposes for the treatment of skin wounds. Strategies for skin regeneration have been developed and dermal substitutes have been used to cover the lesion to facilitate cell proliferation, although very little is known about the application of novel matrix obtained from marine collagen. From food waste we isolated eco-friendly collagen, naturally enriched with glycosaminoglycans, to produce an innovative marine-derived biomaterial assembled as a novel bi-layered skin substitute (Marine Collagen Dermal Template or MCDT). The present work carried out a preliminary experimental in vivo comparative analysis between the MCDT and Integra, one of the most widely used dermal templates for wound management, in a rat model of full-thickness skin wounds. Clinical, histological, and molecular evaluations showed that the MCDT might be a valuable tool in promoting and supporting skin wound healing: it is biocompatible, as no adverse reactions were observed, along with stimulating angiogenesis and the deposition of mature collagen. Therefore, the two dermal templates used in this study displayed similar biocompatibility and outcome with focus on full-thickness skin wounds, although a peculiar cellular behavior involving the angiogenesis process was observed for the MCDT.

Published
2023
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34. A Second Life for Seafood Waste: Therapeutical Promises of Polyhydroxynapthoquinones Extracted from Sea Urchin by-Products

Author

Luca Melotti, Andrea Venerando, Giulia Zivelonghi, Anna Carolo, Stefania Marzorati, Giordana Martinelli, Michela Sugni, Lisa Maccatrozzo, and Marco Patruno

Subjects
polyhydroxynaphtoquinones, spinochromes, sea urchin, antioxidant, marine food waste, zero-waste approach, Therapeutics. Pharmacology, RM1-950
Abstract

Coping with a zero-waste, more sustainable economy represents the biggest challenge for food market nowadays. We have previously demonstrated that by applying smart multidisciplinary waste management strategies to purple sea urchin (Paracentrotus lividus) food waste, it is possible to obtain both a high biocompatible collagen to produce novel skin substitutes and potent antioxidant pigments, namely polyhydroxynapthoquinones (PHNQs). Herein, we have analyzed the biological activities of the PHNQs extract, composed of Spinochrome A and B, on human skin fibroblast cells to explore their future applicability in the treatment of non-healing skin wounds with the objective of overcoming the excessive oxidative stress that hinders wound tissue regeneration. Our results clearly demonstrate that the antioxidant activity of PHNQs is not restricted to their ability to scavenge reactive oxygen species; rather, it can be traced back to an upregulating effect on the expression of superoxide dismutase 1, one of the major components of the endogenous antioxidant enzymes defense system. In addition, the PHNQs extract, in combination with Antimycin A, displayed a synergistic pro-apoptotic effect, envisaging its possible employment against chemoresistance in cancer treatments. Overall, this study highlights the validity of a zero-waste approach in the seafood chain to obtain high-value products, which, in turn, may be exploited for different biomedical applications.

Published
2023
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35. Stereotactic Radiosurgery for Cavernous Sinus Meningiomas

Author

Longhi, Michele, Bulgarelli, Giorgia, Foroni, Roberto, Zivelonghi, Emanuele, Ricciardi, Giuseppe Kenneth, Polloniato, Paolo, D’Amico, Anna, Lardani, Jacopo, Sala, Francesco, Pinna, Giampietro, Nicolato, Antonio, Longhi, Michele, editor, Motti, Enrico D. F., editor, Nicolato, Antonio, editor, and Picozzi, Piero, editor

Published
2021
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37. Prosthesis Infolding Incidence And Short-Term Outcomes In TAVI Using Evolut Self-Expandable Device: A Multicenter Study

Author

Bezzeccheri, Andrea, primary, Poletti, Enrico, additional, Vermeersch, Paul, additional, Veulemans, Verena, additional, Piuhola, Jarkko, additional, Kerkelä, Seija, additional, Lehtola, Heidi, additional, De Backer, Ole, additional, Quagliana, Angelo, additional, Mammone, Concetta, additional, Ribichini, Flavio, additional, Prihadi, Edgard, additional, Scott, Benjamin, additional, Zivelonghi, Carlo, additional, Verheye, Stefan, additional, and Agostoni, Pierfrancesco, additional

Published
2024
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43. X-ray microtomography of heavy microstructures: the case of Plasma-Sprayed Tungsten and Tungsten-Steel MMC

Author

Zivelonghi, A., Weitkamp, T., Larrue, A., and You, J-H.

Subjects
Condensed Matter - Materials Science
Abstract

In this paper synchrotron microtomography on Plasma Sprayed Tungsten (PS-W) is presented and discussed. PS-W is a challenging material for microtomography since it exhibits a random porous network at different length-scales (from nanometers to micrometers) and is hardly penetrable by X-rays. Furthermore, inner porosity causes strong internal scattering. The key challenges were, firstly, to optimize the beam parameters considering the inherent trade-off between photon energy (penetration depth) and spatial resolution and, secondly, to develop effective signal filtering algorithms. Despite the limited signal-to-noise ratio detected, large volumes of PS-W could be reconstructed with good image quality and micrometric resolution (voxel size = 1.4 {\mu}m). As an important result, we report excellent image quality and higher penetration depth by applying the same setup on a ferrous microstructure, namely a 10%W/Steel MMC used as interlayer between PS-W and a ferritic/martensitic steel substrate. The paper reports a detailed 3D morphological analysis of all inclusion types in PS-W and W/Steel, which led to disclosure of a complex connected porous network in both media. The analysis is presented in terms of multiphase volume fraction, ratio of percolation and 3D shape descriptors. 3D percolation patterns are analyzed in detail and sensitivity towards segmentation threshold for the noise-affected PS-W region is discussed. Remarkably, percolation of the porous phase was found throughout the entire coating thickness of PS-W. In W-Steel MMC percolation was found in the perpendicular plane and interpreted as onset of delamination caused by thermomechanical stress., Comment: 18 pages, 12 figures

Published
2015

45. Neuronal intermediate filament IgGs in CSF: Autoimmune Axonopathy Biomarkers

Author

Andrew McKeon, Shahar Shelly, Cecilia Zivelonghi, Eati Basal, Divyanshu Dubey, Eoin Flanagan, Ajay A. Madhavan, Sara Mariotto, Michel Toledano, Jennifer A. Tracy, Anastasia Zekeridou, and Sean J. Pittock

Subjects
Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurology. Diseases of the nervous system, RC346-429
Abstract

Abstract Objectives To describe CSF‐defined neuronal intermediate filament (NIF) autoimmunity. Methods NIF‐IgG CSF‐positive patients (41, 0.03% of 118599 tested, 1996–2019) were included (serum was neither sensitive nor specific). Criteria‐based patient NIF‐IgG staining of brain and myenteric NIFs was detected by indirect immunofluorescence assay (IFA); NIF‐specificity was confirmed by cell‐based assays (CBAs, alpha internexin, neurofilament light [NF‐L]), heavy‐[NF‐H] chain). Results Sixty‐one percent of 41 patients were men, median age, 61 years (range, 21–88). Syndromes were encephalopathy predominant (23), cerebellar ataxia predominant (11), or myeloradiculoneuropathies (7). MRI abnormalities (T2 hyperintensities of brain, spinal cord white matter tracts. and peripheral nerve axons) and neurophysiologic testing (EEG, EMG, evoked potentials) co‐localized with clinical neurological phenotypes (multifocal in 29%). Thirty patients (73%) had ≥ 1 immunological perturbation: cancer (paraneoplastic), 22; systemic infection (parainfectious [including ehrlichosis, 3] or HIV), 7; checkpoint‐inhibitor cancer immunotherapy, 4; other, 5. Cancers were as follows: neuroendocrine‐lineage carcinomas, 12 (small cell, 6; Merkel cell, 5; pancreatic, 1 [11/12 had NF‐L‐IgG detected, versus 8/29 others, P = 0.0005]) and other, 11. Onset was predominantly subacute (92%) and accompanied by inflammatory CSF (75%), and immunotherapy response (77%). In contrast, CSF controls (15684 total) demonstrated NIF‐IgG negativity (100% of test validation controls), and low frequencies of autoimmune diagnoses (20% of consecutively referred clinical specimens) and neuroendocrine‐lineage carcinoma diagnosis (3.1% vs. 30% of NIF cases), P

Published
2021
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47. Magnetic resonance-guided focused ultrasound unilateral thalamotomy for medically refractory essential tremor: 3-year follow-up data.

Author

Tamburin, Stefano, Paio, Fabio, Bovi, Tommaso, Bulgarelli, Giorgia, Longhi, Michele, Foroni, Roberto, Mantovani, Elisa, Polloniato, Paolo Maria, Tagliamonte, Micaela, Zivelonghi, Emanuele, Zucchella, Chiara, Cavedon, Carlo, Nicolato, Antonio, Petralia, Benedetto, Sala, Francesco, Bonetti, Bruno, Tinazzi, Michele, Montemezzi, Stefania, and Ricciardi, Giuseppe Kenneth

Subjects
ESSENTIAL tremor, TREMOR, LITERATURE reviews, MAGNETIC resonance imaging, REFRACTORY materials, QUALITY of life
Abstract

Introduction: Magnetic resonance-guided focused ultrasound (MRgFUS) thalamotomy of the ventralis intermediate (Vim) nucleus is an "incisionless" treatment for medically refractory essential tremor (ET). We present data on 49 consecutive cases of MRgFUS Vim thalamotomy followed-up for 3 years and review the literature on studies with longer follow-up data. Methods: A retrospective chart review of patients who underwent MRgFUS thalamotomy (January 2018-December 2020) at our institution was performed. Clinical Rating Scale for Tremor (CRST) and Quality of Life in Essential Tremor (QUEST) scores were obtained pre-operatively and at each follow-up with an assessment of side effects. Patients had post-operative magnetic resonance imaging within 24h and at 1 month to figure out lesion location, size, and extent. The results of studies with follow-up ≥3 years were summarized through a literature review. Results: The CRST total (baseline: 58.6 ± 17.1, 3-year: 40.8 ± 18.0) and subscale scores (A + B, baseline: 23.5 ± 6.3, 3-year: 12.8 ± 7.9; C, baseline: 12.7 ± 4.3, 3-year: 5.8 ± 3.9) and the QUEST score (baseline: 38.0 ± 14.8, 3-year: 18.7 ± 13.3) showed significant improvement that was stable during the 3-year follow-up. Three patients reported tremor recurrence and two were satisfactorily retreated. Side effects were reported by 44% of patients (severe: 4%, mild and transient: 40%). The improvement in tremor and quality of life in our cohort was consistent with the literature. Conclusion: We confirmed the effectiveness and safety of MRgFUS Vim thalamotomy in medically refractory ET up to 3 years. [ABSTRACT FROM AUTHOR]

Published
2024
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