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371 results on '"Zink, M. Christine"'

1. SIV Latency in Macrophages in the CNS

Author

Gama, Lucio, Abreu, Celina, Shirk, Erin N., Queen, Suzanne E., Beck, Sarah E., Metcalf Pate, Kelly A., Bullock, Brandon T., Zink, M. Christine, Mankowski, Joseph L., Clements, Janice E., Compans, Richard W, Series Editor, Malissen, Bernard, Series Editor, Aktories, Klaus, Series Editor, Rappuoli, Rino, Series Editor, Galan, Jorge E, Series Editor, Ahmed, Rafi, Series Editor, Palme, Klaus, Series Editor, Casadevall, Arturo, Series Editor, Garcia-Sastre, Adolfo, Series Editor, Iwasaki, Akiko, Series Editor, Akira, Shizuo, Series Editor, Silvestri, Guido, editor, and Lichterfeld, Mathias, editor

Published
2018
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7. A Murine Viral Outgrowth Assay to Detect Residual HIV Type 1 in Patients With Undetectable Viral Loads

Author

Pate, Kelly A. Metcalf, Pohlmeyer, Christopher W., Walker-Sperling, Victoria E., Foote, Jeremy B., Najarro, Kevin M., Cryer, Catherine G., Salgado, Maria, Gama, Lucio, Engle, Elizabeth L., Shirk, Erin N., Queen, Suzanne E., Chioma, Stanley, Vermillion, Meghan S., Bullock, Brandon, Li, Ming, Lyons, Claire E., Adams, Robert J., Zink, M. Christine, Clements, Janice E., Mankowski, Joseph L., and Blankson, Joel N.

Published
2015

13. Advancing Translational Research

Author

BOLON, BRAD, ALTROCK, BRUCE, BARTHOLD, STEPHEN W., BAUMGARTH, NICOLE, BESSELSEN, DAVID, BOIVIN, GREGORY, BOYD, KELLI L., BRAYTON, CORY, CARDIFF, ROBERT D., COUTO, SUZANA, EATON, KATHRYN A., FOREMAN, ODED, GRIFFEY, STEPHEN M., LA PERLE, KRISTA, LAIRMORE, MICHAEL D., LIU, CHEN, MEYERHOLZ, DAVID K., NIKITIN, ALEXANDER YU., SCHOEB, TRENTON R., SCHWAHN, DENISE, SELLERS, RANI S., SUNDBERG, JOHN P., TOLWANI, RAVI, VALLI, VICTOR E., and ZINK, M. CHRISTINE

Published
2011
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17. Antiretroviral drugs induce oxidative stress and neuronal damage in the central nervous system

Author

Akay, Cagla, Cooper, Michael, Odeleye, Akinleye, Jensen, Brigid K., White, Michael G., Vassoler, Fair, Gannon, Patrick J., Mankowski, Joseph, Dorsey, Jamie L., Buch, Alison M., Cross, Stephanie A., Cook, Denise R., Peña, Michelle-Marie, Andersen, Emily S., Christofidou-Solomidou, Melpo, Lindl, Kathryn A., Zink, M. Christine, Clements, Janice, Pierce, R. Christopher, Kolson, Dennis L., and Jordan-Sciutto, Kelly L.

Published
2014
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33. Neuroprotective and anti-human immunodeficiency virus activity of minocycline

Author

Zink, M. Christine, DeWitt, Jesse, Bullock, Brandon, Tarwater, Patrick, Barber, Sheila, Uhrlaub, Jennifer, Voelker, Tauni, Mankowski, Joseph, and Clements, Janice

Subjects
HIV antigens -- Research, Minocycline -- Research
Abstract

A study is conducted to examine the ability of minocycline, an antibiotic with potent anti-inflammatory and neuroprotective properties, to protect against encephalitis and neuro-degeneration using a rapid, high viral load simian immunodeficiency virus (SIV) model of HIV-associated CNS disease that constitutes a rigorous in vivo test for potential therapeutics. The conclusions suggested that minocycline, a safe, inexpensive, and readily available antibiotic should be investigated as an anti-HIV therapeutic.

Published
2005

35. Simian Immunodeficiency Virus

Author

Zink, M. Christine, primary, Mankowski, Joseph L., additional, Graham, David R., additional, Gama, Lucio, additional, and Clements, Janice E., additional

Published
2011
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41. CD4-independent, CCR5-dependent infection of brain capillary endothelial cells by a neuroviolent simian immunodeficiency virus strain

Author

Edinger, Aimee L., Mankowski, Joseph L., Doranz, Benjamin J., Margulies, Barry J., Lee, Benhur, Rucker, Joseph, Sharron, Matthew, Hoffman, Trevor L., Berson, Joanne F., Zink, M. Christine, Hirsch, Vanessa M., Clements, Janice E., and Doms, Robert W.

Subjects
Brain -- Physiological aspects, Rhesus monkey -- Physiological aspects, Simian immunodeficiency virus -- Physiological aspects, Viral genetics -- Research, Science and technology
Abstract

Brain capillary endothelial cells (BCECs) are targets of CD4-independent infection by HIV-1 and simian immunodeficiency virus (SIV) strains in vitro and in vivo. Infection of BCECs may provide a portal of entry for the virus into the central nervous system and could disrupt blood-brain barrier function, contributing to the development of AIDS dementia. We found that rhesus macaque BCECs express chemokine receptors involved in HIV and SIV entry including CCR5, CCR3, CXCR4, and STRL33, but not CCR2b, GPR1, or GPR15. Infection of BCECs by the neurovirulent strain SIV/17E-Fr was completely inhibited by aminooxypentane regulation upon activation, normal T cell expression and secretion in the presence or absence of ligands, but not by eotaxin or antibodies to CD4. We found that the envelope (env) proteins from SIV/17E-Fr and several additional SIV strains mediated cell-cell fusion and virus infection with CD4-negative, CCR5-positive cells. In contrast, fusion with cells expressing the coreceptors STRL33, GPR1, and GPR15 was CD4-dependent. These results show that CCR5 can serve as a primary receptor for SIV in BCECs and suggest a possible CD4-independent mechanism for blood-brain barrier disruption and vital entry into the central nervous system.

Published
1997

47. Brain Macrophages in Simian Immunodeficiency Virus-Infected, Antiretroviral-Suppressed Macaques: a Functional Latent Reservoir

Author

Avalos, Claudia R., primary, Abreu, Celina M., additional, Queen, Suzanne E., additional, Li, Ming, additional, Price, Sarah, additional, Shirk, Erin N., additional, Engle, Elizabeth L., additional, Forsyth, Ellen, additional, Bullock, Brandon T., additional, Mac Gabhann, Feilim, additional, Wietgrefe, Stephen W., additional, Haase, Ashley T., additional, Zink, M. Christine, additional, Mankowski, Joseph L., additional, Clements, Janice E., additional, and Gama, Lucio, additional

Published
2017
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49. HIV Protease Inhibitors Alter Amyloid Precursor Protein Processing via β-Site Amyloid Precursor Protein Cleaving Enzyme-1 Translational Up-Regulation

Author

Gannon, Patrick J., primary, Akay-Espinoza, Cagla, additional, Yee, Alan C., additional, Briand, Lisa A., additional, Erickson, Michelle A., additional, Gelman, Benjamin B., additional, Gao, Yan, additional, Haughey, Norman J., additional, Zink, M. Christine, additional, Clements, Janice E., additional, Kim, Nicholas S., additional, Van De Walle, Gabriel, additional, Jensen, Brigid K., additional, Vassar, Robert, additional, Pierce, R. Christopher, additional, Gill, Alexander J., additional, Kolson, Dennis L., additional, Diehl, J. Alan, additional, Mankowski, Joseph L., additional, and Jordan-Sciutto, Kelly L., additional

Published
2017
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50. Seoul virus infection increases aggressive behavior in male Norway rats

Author

Klein, Sabra L., Zink, M. Christine, and Glass, Gregory E.

Subjects
Rattus -- Health aspects, Rattus -- Research, Rats -- Health aspects, Rats -- Research, Hantavirus infections -- Risk factors, Hantavirus infections -- Research, Hantavirus infections -- Influence, Animal behavior -- Research, Zoology and wildlife conservation
Abstract

The Hantavirus infection that causes an increase in aggression in male rats is determined. Determination of whether behavioral changes are due to infection of the central nervous system or peripheral tissues is done which showed that Seoul virus did not alter either testosterone or corticosterone concentrations.

Published
2004

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