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Your search keyword '"Zinchenko, Galina N."' showing total 5 results
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5 results on '"Zinchenko, Galina N."'

2. The Mechanisms of GPR55 Receptor Functonal Selectivity

Author

Akimov, Mikhail G, primary, Gretskaya, Natalia M, additional, Dudina, Polina V, additional, Sherstyanykh, Galina, additional, Zinchenko, Galina N, additional, Serova, Oksana V, additional, Degtyaryova, Ksenia O, additional, Deyev, Igor E, additional, and Bezuglov, Vladimir V, additional

Published
2022
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4. Arachidonoylcholine and Other Unsaturated Long-Chain Acylcholines Are Endogenous Modulators of the Acetylcholine Signaling System

Author

Akimov, Mikhail G., primary, Kudryavtsev, Denis S., additional, Kryukova, Elena V., additional, Fomina-Ageeva, Elena V., additional, Zakharov, Stanislav S., additional, Gretskaya, Natalia M., additional, Zinchenko, Galina N., additional, Serkov, Igor V., additional, Makhaeva, Galina F., additional, Boltneva, Natalia P., additional, Kovaleva, Nadezhda V., additional, Serebryakova, Olga G., additional, Lushchekina, Sofya V., additional, Palikov, Victor A., additional, Palikova, Yulia, additional, Dyachenko, Igor A., additional, Kasheverov, Igor E., additional, Tsetlin, Victor I., additional, and Bezuglov, Vladimir V., additional

Published
2020
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5. Cytotoxicity of Endogenous Lipids N-acyl Dopamines and their Possible Metabolic Derivatives for Human Cancer Cell Lines of Different Histological Origin.

Author

Akimov MG, Gretskaya NM, Zinchenko GN, and Bezuglov VV

Subjects
Animals, Dopamine analogs & derivatives, Fatty Acids metabolism, Glioblastoma pathology, HEK293 Cells, Humans, MCF-7 Cells, Neoplasms pathology, Structure-Activity Relationship, Dopamine metabolism, Glioblastoma metabolism, Lipids, Neoplasms metabolism
Abstract

Background/aim: Dopamine amides of long chain fatty acids are a family of endogenous mammalian lipids with an unknown function; they are anti-proliferative for the C6 glioblastoma cell line. To assess their possible anti-cancer activity we evaluated their cytotoxicity for a set of cancer cell lines., Materials and Methods: Anti-proliferative and cytotoxic actions of these substances were evaluated in HOS, IMR-32, MCF-7, Namalwa, K-562 and HEK 293 cell lines (18 h incubation time) using MTT and lactate dehydrogenase (LDH) tests, accordingly., Results: All N-acyl dopamines (NADA) induced cell death in all cell lines tested with a 50% lethal dose (LD50) in the range of 0.5-80 μM, except for HEK-293. For HEK-293 only N-arachidonoyl epinephrine demonstrated an LD50 below 100 μM., Conclusion: According to the structure-activity relationship, N-acyl dopamines with an intact catechol group and a non-modified hydrophobic fatty acid residue are cytotoxic to cancer cell lines of various histological origins., (Copyright© 2015 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved.)

Published
2015

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