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1,949 results on '"Zimmermann, Robert"'

3. Peptidyl nitroalkene inhibitors of main protease rationalized by computational and crystallographic investigations as antivirals against SARS-CoV-2

Author

Medrano, Francisco J., de la Hoz-Rodríguez, Sergio, Martí, Sergio, Arafet, Kemel, Schirmeister, Tanja, Hammerschmidt, Stefan J., Müller, Christin, González-Martínez, Águeda, Santillana, Elena, Ziebuhr, John, Romero, Antonio, Zimmer, Collin, Weldert, Annabelle, Zimmermann, Robert, Lodola, Alessio, Świderek, Katarzyna, Moliner, Vicent, and González, Florenci V.

Published
2024
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5. Blockchain for Food Traceability - Consumer Requirements in Austria

Author

Zimmermann, Robert, Richter, Magdalena, Brandtner, Patrick, Goos, Gerhard, Series Editor, Hartmanis, Juris, Founding Editor, van Leeuwen, Jan, Series Editor, Hutchison, David, Editorial Board Member, Kanade, Takeo, Editorial Board Member, Kittler, Josef, Editorial Board Member, Kleinberg, Jon M., Editorial Board Member, Kobsa, Alfred, Series Editor, Mattern, Friedemann, Editorial Board Member, Mitchell, John C., Editorial Board Member, Naor, Moni, Editorial Board Member, Nierstrasz, Oscar, Series Editor, Pandu Rangan, C., Editorial Board Member, Sudan, Madhu, Series Editor, Terzopoulos, Demetri, Editorial Board Member, Tygar, Doug, Editorial Board Member, Weikum, Gerhard, Series Editor, Vardi, Moshe Y, Series Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Woeginger, Gerhard, Editorial Board Member, Nah, Fiona Fui-Hoon, editor, and Siau, Keng Leng, editor

Published
2024
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9. Consumer Behavior in Staffless Stores: A Systematic Literature Review

Author

Staab, Marina, Zimmermann, Robert, Brandtner, Patrick, Schauer, Oliver, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Zaphiris, Panayiotis, editor, Ioannou, Andri, editor, Sottilare, Robert A., editor, Schwarz, Jessica, editor, Fui-Hoon Nah, Fiona, editor, Siau, Keng, editor, Wei, June, editor, and Salvendy, Gavriel, editor

Published
2023
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10. Implications of 3D Printing on Physical Distribution in Logistics and Supply Chain Management

Author

Brandtner, Patrick, Zimmermann, Robert, Allmendinger, Jessika, Kacprzyk, Janusz, Series Editor, Gomide, Fernando, Advisory Editor, Kaynak, Okyay, Advisory Editor, Liu, Derong, Advisory Editor, Pedrycz, Witold, Advisory Editor, Polycarpou, Marios M., Advisory Editor, Rudas, Imre J., Advisory Editor, Wang, Jun, Advisory Editor, Yang, Xin-She, editor, Sherratt, R. Simon, editor, Dey, Nilanjan, editor, and Joshi, Amit, editor

Published
2023
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12. Inhibition of ATGL alleviates MASH via impaired PPARα signalling that favours hydrophilic bile acid composition in mice

Author

Dixon, Emmanuel Dauda, Claudel, Thierry, Nardo, Alexander Daniel, Riva, Alessandra, Fuchs, Claudia, Mlitz, Veronika, Busslinger, Georg, Schnarnagl, Hubert, Stojakovic, Tatjana, Senéca, Joana, Hinteregger, Helga, Grabner, Gernot F., Kratky, Dagmar, Verkade, Henkjan, Zimmermann, Robert, Haemmerle, Guenter, and Trauner, Michael

Published
2024
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13. Fatty acid desaturation by stearoyl-CoA desaturase-1 controls regulatory T cell differentiation and autoimmunity

Author

Grajchen, Elien, Loix, Melanie, Baeten, Paulien, Côrte-Real, Beatriz F., Hamad, Ibrahim, Vanherle, Sam, Haidar, Mansour, Dehairs, Jonas, Broos, Jelle Y., Ntambi, James M., Zimmermann, Robert, Breinbauer, Rolf, Stinissen, Piet, Hellings, Niels, Verberk, Sanne G. S., Kooij, Gijs, Giera, Martin, Swinnen, Johannes V., Broux, Bieke, Kleinewietfeld, Markus, Hendriks, Jerome J. A., and Bogie, Jeroen F. J.

Published
2023
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15. Charged particle guiding and beam splitting with auto-ponderomotive potentials on a chip

Author

Zimmermann, Robert, Seidling, Michael, and Hommelhoff, Peter

Subjects
Physics - Applied Physics, Physics - Instrumentation and Detectors, Quantum Physics, 78A37, 78A35, 78A30, 78A15, J.2
Abstract

We report guiding and manipulation of charged particle beams by means of electrostatic optics based on a principle similar to the electrodynamic Paul trap. We use hundreds of electrodes fabricated on planar substrates and supplied with static voltages to create a ponderomotive potential for charged particles in motion. Shape and strength of the potential can be locally tailored by the electrodes' layout and the applied voltages, enabling the control of charged particle beams within precisely engineered effective potentials. We demonstrate guiding of electrons and ions for a large range of energies (from 20 to 5000 eV) and masses (5E-4 to 131 atomic mass units) as well as electron beam splitting as a proof-of-concept for more complex beam manipulation. Simultaneous confinement of charged particles with different masses is possible, as well as guiding of electrons with energies in the keV regime, and the creation of highly customizable potential landscapes, which is all hard to impossible with conventional electrodynamic Paul traps., Comment: Main text: 4 pages, 4 figures; Supplementary Material: 3 pages, 4 figures; in total: 7 pages, 8 figures

Published
2020
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40. Nanomole Scale Screening of Fluorescent RNA‐Methyltransferase Probes Enables the Discovery of METTL1 Inhibitors.

Author

Meidner, J. Laurenz, Frey, Ariane F., Zimmermann, Robert A., Sabin, Mark O., Nidoieva, Zarina, Weldert, Annabelle C., Hoba, Sabrina N., Krone, Mackenzie W., and Barthels, Fabian

Subjects
DRUG discovery, FLUORESCENT probes, PHARMACEUTICAL chemistry, RNA methylation, DRUG target
Abstract

RNA methylation is a metabolic process validated for its association with various diseases, and thus, RNA methyltransferases (MTases) have become increasingly important in drug discovery. Yet, most frequently utilized RNA MTase assays are limited in their throughput and hamper this rapidly evolving field of medicinal chemistry. In this study, we describe a modular nanomole scale building block system that allowed the identification of tailored fluorescent MTase probes to unlock a broad selection of MTase drug targets for fluorescence‐based binding assays. Probe candidates were initially prepared on a 4 nanomole scale and could be tested directly from crude reaction mixtures to allow rapid probe identification and optimization. Using an alkyne‐azide click late‐stage functionalization strategy and in silico protein databank mining, we established a selection of fluorescent probes suitable for relevant drug targets from the METTL and NSUN families, as well as bacterial and viral MTases. Using this concept, a high‐throughput screening on the unexplored drug target METTL1 discovered three hit compounds with micromolar potency providing a (1H‐pyrazol‐4‐yl)pyridine‐based starting point for METTL1 drug discovery. [ABSTRACT FROM AUTHOR]

Published
2024
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41. Screening fluoreszenter RNA‐Methyltransferase‐Sonden im Nanomolmaßstab ermöglicht die Entdeckung von METTL1‐Inhibitoren.

Author

Meidner, J. Laurenz, Frey, Ariane F., Zimmermann, Robert A., Sabin, Mark O., Nidoieva, Zarina, Weldert, Annabelle C., Hoba, Sabrina N., Krone, Mackenzie W., and Barthels, Fabian

Abstract

Copyright of Angewandte Chemie is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2024
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42. Information Technology as Enabler of Transparency in Food Supply Chains - An Empirical Study

Author

Zimmermann, Robert, Wetzlinger, Werner, Mayer, Magdalena, Obermeier, Gabriele, Auinger, Andreas, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Woeginger, Gerhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Nah, Fiona Fui-Hoon, editor, and Siau, Keng, editor

Published
2021
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46. Dual Strategy to Design New Agents Targeting Schistosoma mansoni: Advancing Phenotypic and SmCB1 Inhibitors for Improved Efficacy

Author

Fuchs, Natalie, primary, Zimmermann, Robert A., additional, Schwickert, Marvin, additional, Gunkel, Annika, additional, Zimmer, Collin, additional, Meta, Mergim, additional, Schwickert, Kevin, additional, Keiser, Jennifer, additional, Haeberli, Cécile, additional, Kiefer, Werner, additional, and Schirmeister, Tanja, additional

Published
2024
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47. The Effect of Queuing Technology on Customer Experience in Physical Retail Environments

Author

Obermeier, Gabriele, Zimmermann, Robert, Auinger, Andreas, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Woeginger, Gerhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Nah, Fiona Fui-Hoon, editor, and Siau, Keng, editor

Published
2020
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