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2 results on '"Zim, A. F. M. I. U."'

1. Quality and Safety Assessment of Bangladeshi Pasteurized Milk.

Author

Ahmed, S., Zim, A. F. M. I. U., Rahman, S., Ghosh, S., Chhetri, A., and Ali, M. S.

Subjects
PASTEURIZATION of milk, FOOD safety, FOOD quality
Abstract

Background: Milk is considered as one of the highly nutritious food for human. This study was undertaken to evaluate the physicochemical as well as the microbial quality of pasteurized milk of different brands available in Chittagong, Bangladesh. Methods: Five types of branded pasteurized liquid milk were collected from retail markets of Chittagong, Bangladesh. Physicochemical analyses were carried out in order to determine the levels of pH, acidity, fat, protein, casein, specific gravity, Solids-Not-Fat (SNF), and total solids of the samples. Also, the samples were analyzed microbiologically to assess the total microbial loads and coliforms. Statistical analysis was done using SPSS software version 23.0. Results: The ranges of physicochemical parameters of the samples were determined, including specific gravity (1.024-1.031), pH (5.8-6.7), acidity (0.17±0.01-0.37±0.01%), total solids content (8.17-12.27%), SNF (7.28-8.49%), fat (0.89-3.78%), protein (3.42±0.09-3.63±0.02%), and casein content (2.66±0.07-2.82±0.02%). Statistically significant differences (p<0.05) were recorded among different milk brands for all physicochemical parameters except specific gravity. The highest and lowest amounts of total bacterial counts were 1150400 and 35500 CFU/ml, respectively. A significant difference (p<0.05) was found in bacterial loads among different brands of pasteurized milk. Conclusion: This survey revealed that different brands of Bangladeshi pasteurized milk did not maintain the standard and acceptable quality. [ABSTRACT FROM AUTHOR]

Published
2019
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2. Pharmacological insights and prediction of lead bioactive isolates of Dita bark through experimental and computer-aided mechanism

Author

Mohammad Arman, Tommaso Venneri, Shaifullah Mansur Tanzil, Suhel Ahmed, A F M Irfan Uddin Zim, Mohammad Forhad Khan, Areeful Haque, Chadni Lyzu, Abdus Shukur Imran, Barbara Romano, Raffaele Capasso, Faisal Bin Kader, Shahenur Alam Sakib, Khan, M. F., Kader, F. B., Arman, M., Ahmed, S., Lyzu, C., Sakib, S. A., Tanzil, S. M., Zim, A. F. M. I. U., Imran, M. A. S., Venneri, T., Romano, B., Haque, M. A., and Capasso, R.

Subjects
0301 basic medicine, Male, Anti-Inflammatory Agents, Antidepressant, Pharmacology, Mice, 0302 clinical medicine, GC–MS, ADME, biology, Chemistry, Depression, General Medicine, Antidepressive Agents, Phytochemical, 030220 oncology & carcinogenesis, Molecular docking, Lipinski's rule of five, Plant Bark, Female, Adult, Alstonia scholaris (L.) R. Br, medicine.drug_class, Alstonia scholaris, RM1-950, Anti-inflammatory, Gas Chromatography-Mass Spectrometry, 03 medical and health sciences, Young Adult, Fibrinolytic Agents, In vivo, medicine, Thrombolytic Agent, Animals, Humans, Computer Simulation, Dita bark, Inflammation, Dose-Response Relationship, Drug, Plant Extracts, Anticoagulant, Thrombosis, biology.organism_classification, Tail suspension test, Disease Models, Animal, 030104 developmental biology, Therapeutics. Pharmacology, Alstonia
Abstract

Dita bark (Alstonia scholaris (L.) R. Br.) is an ethnomedicine used for the management of various ailments. This study aimed to investigate the biological properties of methanol extract of A. scholaris bark (MEAS), through in vivo, in vitro and in silico approaches alongside its phytochemical profiling. Identification and nature of the bioactive secondary metabolites were studied by the established qualitative tests and GC-MS analysis. The antidepressant activity was determined by forced swimming test (FST) and tail suspension test (TST) in mice. The anti-inflammatory and thrombolytic effect was evaluated using inhibition of protein denaturation technique and clot lysis technique, respectively. Besides, computational studies of the isolated compounds and ADME/T analysis were performed by Schrodinger-Maestro (v11.1) software, and PASS prediction was conducted through PASS online tools. The GC-MS analysis revealed the presence of several secondary metabolites in MEAS. Treatment with MEAS revealed a significant reduction of immobility time in a dose-dependent manner in FST and TST. Besides, MEAS showed substantial anti-inflammatory effects at the higher dose (400 μg/mL) as well as revealed notable clot lysis effect as compared to control. In the case of computer-aided investigation, all compounds meet the condition of Lipinski's rule of five. PASS study also predicted for all compounds, and among these safe compound furazan-3-amine showed the most spontaneous binding energy for both antidepressant and thrombolytic activities, as well as 5-dimethylamino-6 azauracil, found promising for anti-inflammatory activity. Taken together, the investigation concludes that MEAS can be a potent source of antidepressant, anti-inflammatory, and thrombolytic agents.

Published
2020

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