13 results on '"Ziedina I"'
Search Results
2. Association of HHV-6 and HHV-7 reactivation with the development of chronic allograft nephropathy
- Author
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Chapenko, S., Folkmane, I., Ziedina, I., Chistyakovs, M., Rozentals, R., Krumina, A., and Murovska, M.
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- 2009
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3. Risk Factors for the Development of Delayed Graft Function in Deceased Donor Renal Transplants
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Jushinskis, J., Trushkov, S., Bicans, J., Suhorukov, V., Shevelev, V., Ziedina, I., and Rozental, R.
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- 2009
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4. Reactivation of BK Virus in the Early Period After Kidney Transplantation
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Ziedina, I., Folkmane, I., Chapenko, S., Murovska, M., Sultanova, A., Jushinskis, J., and Rozental, R.
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- 2009
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5. Genetic and phenotypic parameters for reproduction traits of landrace sows in Latvia
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Ziedina, I., Daina Jonkus, and Paura, L.
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animal diseases ,pig ,reproduction ,genetic parameters - Abstract
The aim of this study was to investigate reproduction performance in the 1st and 2nd parity of Latvian Landrace sows, to estimate genetic parameters for reproduction traits, and to determine their genetic correlations with age at the first farrowing (AFF) and weaning to insemination interval (WII) in the Latvian Landrace swine population. Data from 2054 of the 1st parity and 1416 of the 2nd parity sows were collected from 2005 till 2010 and were included in the analysis. Four reproduction traits in the study were analysed: number of piglets born alive (NBA), number of piglets dead (ND), number of piglets weaned per litter (NW) and 21-day litter weight (W21). Genetic parameters were estimated with multi traits animal model using REML procedure. The heritability estimates in the first parity were 0.07, 0.16, 0.36, 0.01 and 0.32 for NBA, NW, W21, AFF and WII, respectively. Between AFF and sows reproduction traits in the first and the second parity unfavourable genetic correlations were found in the present data set. Moderate negative genetic correlation between WII and sows reproduction traits was observed. more...
6. International Nephrology Masterclass in Chronic Kidney Disease: Rationale, Summary, and Future Perspectives.
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Pesce F, Vadalà M, Almeida E, Fernandez B, Fouque D, Malyszko J, Schmidt-Ott K, Stenvinkel P, Wheeler DC, Seidu S, Cebrian A, Dimov N, Pardo MB, Ziedina I, Habashi N, Manrique J, Marques SHM, Gallardo MAV, Shehaj L, Nikolova Vlahova MK, Mendonça L, Ksiazek S, Veltri P, Pezzi G, Patella G, Borelli G, Provenzano M, and Gesualdo L more...
- Abstract
Chronic kidney disease (CKD) is a progressive condition that affects more than 10% of the population worldwide, accounting for more than 843 million (M) individuals. The prevalence of CKD (844 M patients) is higher than that of diabetes mellitus (422 M patients), cancer (42 M patients), and HIV (37 M patients), but people are often less aware of it. Global expert groups predict reductions in the nephrology workforce in the next decade, with a declining interest in nephrology careers. Over time, KDIGO guidelines have also focused on topics related to the prevention or management of CKD patients in real-life settings. On these premises, a new educational program with international experts in the field of nephrology took place from November 2022 until March 2023 in Milan, Italy. This multinational masterclass provided an educational platform providing unbiased education on diagnosis and treatment by sharing the most recent research data on CKD and comorbidities, therefore creating a snowball effect to increase the implementation of best practices worldwide, using examples from 'real-life' patient outcomes. This paper provides an overview of the International Nephrology Masterclass (INM) concept, summarizing the key lectures and discussions, and giving an outline of future key developments. more...
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- 2024
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7. Individualized Decision-Making and Outcomes for the 87-Year-Old Living Kidney Donor: A Case Report.
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Kigitovica D, Kuzema V, Jusinskis J, Mesecko V, Suhorukovs V, Petersons A, and Ziedina I
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Introduction: Latvia faces a challenging shortage of available kidney donors, leading to a significant mismatch between demand for kidney transplantation and supply. Although older adult donors require a thorough pre-donation workup to rule out significant medical comorbidities, it offers hope for potential kidney transplantation candidates., Case Presentation: This case study presents the unique scenario of an 87-year-old living kidney donor, where individualized decision-making resulted in outstanding outcomes for both the donor and recipient., Conclusions: The initial assessment for donation, which involves renal scintigraphy, serves as a preventive measure. In cases where one of the kidneys exhibits insufficient function, this approach avoids the necessity for further costly tests, thus preserving resources in the healthcare budget. The decision concerning an older donor should undergo thorough discussion by a multidisciplinary team to minimize perioperative and long-term risks. Nonetheless, a thoughtful approach to elderly donors offers a valuable opportunity to expand the living donor pool in the context of the organ shortage problem., Competing Interests: The authors have no conflicts of interest to declare., (© 2024 The Author(s). Published by S. Karger AG, Basel.) more...
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- 2024
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8. The ERA Registry Annual Report 2021: a summary.
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Boerstra BA, Boenink R, Astley ME, Bonthuis M, Abd ElHafeez S, Arribas Monzón F, Åsberg A, Beckerman P, Bell S, Cases Amenós A, Castro de la Nuez P, Ten Dam MAGJ, Debska-Slizien A, Gjorgjievski N, Giudotti R, Helve J, Hommel K, Idrizi A, Indriðason ÓS, Jarraya F, Kerschbaum J, Komissarov KS, Kozliuk N, Kravljaca M, Lassalle M, De Meester JM, Ots-Rosenberg M, Plummer Z, Radunovic D, Razvazhaieva O, Resic H, Rodríguez Arévalo OL, Santiuste de Pablos C, Seyahi N, Slon-Roblero MF, Stendahl M, Tolaj-Avdiu M, Trujillo-Alemán S, Ziedina I, Ziginskiene E, Ortiz A, Jager KJ, Stel VS, and Kramer A more...
- Abstract
Background: The European Renal Association (ERA) Registry collects data on kidney replacement therapy (KRT) in patients with end-stage kidney disease (ESKD). This paper is a summary of the ERA Registry Annual Report 2021, including a comparison across treatment modalities., Methods: Data was collected from 54 national and regional registries from 36 countries, of which 35 registries from 18 countries contributed individual patient data and 19 registries from 19 countries contributed aggregated data. Using this data, incidence and prevalence of KRT, kidney transplantation rates, survival probabilities and expected remaining lifetimes were calculated., Result: In 2021, 533.2 million people in the general population were covered by the ERA Registry. The incidence of KRT was 145 per million population (pmp). In incident patients, 55% were 65 years or older, 64% were male, and the most common primary renal disease (PRD) was diabetes (22%). The prevalence of KRT was 1040 pmp. In prevalent patients, 47% were 65 years or older, 62% were male, and the most common PRDs were diabetes and glomerulonephritis/sclerosis (both 16%). On 31 December 2021, 56% of patients received haemodialysis, 5% received peritoneal dialysis, and 39% were living with a functioning graft. The kidney transplantation rate in 2021 was 37 pmp, a majority coming from deceased donors (66%). For patients initiating KRT between 2012-2016, 5-year survival probability was 52%. Compared to the general population, life expectancy was 65% and 68% shorter for males and females receiving dialysis, and 40% and 43% shorter for males and females living with a functioning graft., Competing Interests: None declared., (© The Author(s) 2023. Published by Oxford University Press on behalf of the ERA.) more...
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- 2023
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9. Trends in kidney transplantation rate across Europe: study from the ERA Registry.
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Boenink R, Kramer A, Tuinhout RE, Savoye E, Åsberg A, Idrizi A, Kerschbaum J, Ziedina I, Ziginskiene E, Farrugia E, Garneata L, Zakharova EV, Bell S, Arnol M, Segelmark M, Ioannou K, Hommel K, Rosenberg-Ots M, Vazelov E, Helve J, Mihály S, Pálsson R, Nordio M, Gjorgjievski N, de Vries APJ, Seyahi N, Magadi WA, Resić H, Kalachyk A, Rahmel AO, Galvão AA, Naumovic R, Lundgren T, Arici M, de Meester JM, Ortiz A, Jager KJ, and Stel VS more...
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- Humans, Living Donors, Kidney, Europe epidemiology, Registries, Kidney Transplantation
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Background: The aim of this study was to identify trends in total, deceased donor (DD) and living donor (LD) kidney transplantation (KT) rates in European countries., Methods: The European Renal Association (ERA) Registry and the Global Observatory on Donation and Transplantation (GODT) databases were used to obtain the number of KTs in individual European countries between 2010 and 2018. General population counts were obtained from Eurostat or the national bureaus of statistics. The KT rate per million population (p.m.p.) and the average annual percentage change (APC) were calculated., Results: The total KT rate in the 40 participating countries increased with 1.9% annually [95% confidence interval (CI) 1.5, 2.2] from 29.6 p.m.p. in 2010 to 34.7 p.m.p. in 2018, reflecting an increase of 3.4 p.m.p. in the DD-KT rate (from 21.6 p.m.p. to 25.0 p.m.p.; APC 1.9%; 95% CI 1.3, 2.4) and of 1.5 p.m.p. in the LD-KT rate (from 8.1 p.m.p. to 9.6 p.m.p.; APC 1.6%; 95% CI 1.0, 2.3). The trends in KT rate varied widely across European countries. An East-West gradient was observed for DD-KT rate, with Western European countries performing more KTs. In addition, most countries performed fewer LD-KTs. In 2018, Spain had the highest DD-KT rate (64.6 p.m.p.) and Turkey the highest LD-KT rate (37.0 p.m.p.)., Conclusions: The total KT rate increased due to a rise in the KT rate from DDs and to a lesser extent from LDs, with large differences between individual European countries., (© The Author(s) 2023. Published by Oxford University Press on behalf of the ERA.) more...
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- 2023
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10. Leucine-Rich Alpha-2-Glycoprotein (LRG-1) as a Potential Kidney Injury Marker in Kidney Transplant Recipients.
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Popova A, Vasiļvolfa A, Rācenis K, Erts R, Šlisere B, Saulīte AJ, Ziedina I, Folkmane I, Čerņevskis H, Kroiča J, Pētersons A, and Kuzema V
- Subjects
- Biomarkers, Glycoproteins urine, Humans, Kidney, Leucine, Proteinuria, Cystatin C, Glycoproteins analysis, Kidney Transplantation adverse effects
- Abstract
BACKGROUND Kidney transplantation is the treatment of choice for most patients with end-stage renal disease. To improve patient and transplant survival, non-invasive diagnostic methods for different pathologies are important. Leucine-rich alpha-2-glycoprotein (LRG-1) is an innovative biomarker that is elevated in cases of angiogenesis, inflammation, and kidney injury. However, there are limited data about the diagnostic role of LRG-1 in kidney transplant recipients. The aim of this study was to evaluate the association between serum LRG-1, urine LRG-1, and kidney transplant function and injury. MATERIAL AND METHODS We enrolled 35 kidney transplant recipients in the study. LRG-1 in the serum and urine was detected using ELISA. We evaluated the correlation of serum and urine LRG-1 with traditional serum and urine kidney injury markers. RESULTS A higher level of serum LRG-1 correlates with a higher level of urine LRG-1. Serum LRG-1 has a positive correlation with transplant age, serum urea, serum creatinine, serum cystatin C, proteinuria, and fractional excretion of sodium (FENa) and a negative correlation with hemoglobin and estimated glomerular filtration rate (eGFR). Urine LRG-1 has a positive correlation with serum cystatin C, proteinuria, and urine neutrophil gelatinase-associated lipocalin (NGAL). CONCLUSIONS Higher levels of serum and urine LRG-1 are associated with kidney transplant injury and functional deterioration. Thus, LRG-1 might be also as a biomarker for tubular dysfunction in patients after kidney transplantation. more...
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- 2022
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11. Organ Donation and Transplantation in Latvia.
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Ziedina I, Jushinskis J, Lejniece S, and Strike E
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- Accreditation, Bone Marrow Transplantation, Delayed Graft Function, Humans, Immunosuppression Therapy, Latvia, Living Donors, Organ Transplantation trends, Societies, Medical, Surveys and Questionnaires, Tissue and Organ Procurement trends, Organ Transplantation methods, Tissue Donors, Tissue and Organ Procurement methods
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- 2019
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12. Importance of High-Risk Human Papillomavirus Infection Detection in Female Renal Transplant Recipients in the First Year after Transplantation.
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Cistjakovs M, Sultanova A, Jermakova O, Sokolovska L, Chapenko S, Lesina-Korne B, Rozental R, Murovska M, and Ziedina I
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- Adult, Disease Progression, Female, Humans, Latvia, Middle Aged, Papillomaviridae isolation & purification, Papillomaviridae physiology, Patient Care Management methods, Risk Assessment, Risk Factors, Vaginal Smears methods, Viral Load methods, Immunosuppression Therapy adverse effects, Immunosuppression Therapy methods, Kidney Transplantation adverse effects, Kidney Transplantation methods, Papillomavirus Infections diagnosis, Papillomavirus Infections etiology, Papillomavirus Infections immunology, Papillomavirus Infections prevention & control, Postoperative Complications diagnosis, Postoperative Complications immunology
- Abstract
Objectives: Most of human papillomavirus (HPV) infections are "cleared" by the immune system; however, in cases of immune system suppression, infections could lead to development of malignancies. The aim of this study was to find out the frequency of HR-HPV infection in early period after renal transplantation in recipients receiving immunosuppressive therapy and to follow the progression of the infection up to one year., Methods: 43 female renal transplant recipients and 79 healthy female individuals as a control group were enrolled in this investigation. For the detection of HPV infection, patients' samples (blood and vaginal swabs) were collected two weeks after transplantation with following collection of six months and one year. Different polymerase chain reactions for HR-HPV genomic sequences detection and ELISA kit for detection of anti-HPV IgG antibodies were used., Results: In this study, we show that frequency rate of HR-HPV infection has increased in the first year after transplantation from early stage of immunosuppressive therapy (from 24% to 36%). Also an increase of HR-HPV load was detected over time, showing the highest median viral load at sixth month after transplantation., Conclusions: From the obtained data, it follows that it is very important to carefully monitor patients receiving immunosuppression therapy on progression of HR-HPV. more...
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- 2018
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13. Human papillomavirus type 18 infection in a female renal allograft recipient: a case report.
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Cistjakovs M, Sultanova A, Jermakova O, Chapenko S, Lesina-Korne B, Rozental R, Razeberga D, Murovska M, and Ziedina I
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- Abortion, Spontaneous virology, Adult, DNA-Binding Proteins, Female, Glomerulosclerosis, Focal Segmental drug therapy, Glomerulosclerosis, Focal Segmental immunology, Human Papillomavirus DNA Tests, Humans, Oncogene Proteins, Viral, Papillomavirus Infections complications, Postoperative Complications immunology, Pregnancy, RNA, Messenger, RNA, Viral, Vaginal Smears, Viral Load, Virus Activation, Abortion, Spontaneous immunology, Glomerulosclerosis, Focal Segmental surgery, Human papillomavirus 18 isolation & purification, Immunosuppressive Agents therapeutic use, Kidney Transplantation adverse effects, Papillomavirus Infections immunology, Postoperative Complications virology
- Abstract
Background: Human papillomavirus type 18 is the second most common cause of cervical cancer and is found in 7 to 20 % of cases of cervical cancer. The oncogenic potential of high-risk human papillomavirus is associated with expression of early proteins E6 and E7. Due to long-term immunosuppressive therapy, renal transplant recipients have a higher risk of developing persistent human papillomavirus infection., Case Presentation: A 29-year-old white woman from Latvia with chronic focal segmental glomerulosclerosis received renal allograft transplantation and was prescribed immunosuppressive therapy with cyclosporine, prednisolone, and mycophenolate mofetil. Two weeks after renal transplantation, her cervical swab was positive for human papillomavirus consensus sequences. After 6 months, quantitative polymerase chain reaction showed a high viral load of 3,630,789 copies/10
5 cells of high-risk human papillomavirus type 18 and expression of E6 and E7 oncogenes in her cervical swab and urine sample. One year after renal transplantation, the viral load in her cervical swab increased significantly to 7,413,102 copies/105 cells. Messenger ribonucleic acid of human papillomavirus type 18 E6 and E7 oncogenes were also detected. Shortly after this, she had an unsuccessful pregnancy which resulted in a spontaneous abortion at 6/7 weeks. Two months after the abortion her viral load sharply decreased to 39 copies/105 cells. Oncogenes E6 and E7 messenger ribonucleic acid expression was not observed in this period., Conclusions: This case report represents data which show that immunosuppressive therapy may increase the risk of developing persistent high-risk human papillomavirus infection with expression of E6 and E7 oncogenes in renal transplant recipients. However, even during this therapy the immune status of a recipient can improve and contribute to human papillomavirus viral load reduction. Spontaneous abortion can be considered a possible contributory factor in human papillomavirus clearance. more...- Published
- 2016
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