Search

Your search keyword '"Zidovudine -- Complications and side effects"' showing total 34 results
Start Over Descriptor "Zidovudine -- Complications and side effects"
34 results on '"Zidovudine -- Complications and side effects"'

1. Human immunodeficiency virus treatment-induced adipose tissue pathology and lipoatrophy: prevalence and metabolic consequences

Author

Hammond, Emma, McKinnon, Elizabeth, and Nolan, David

Subjects
Lipodystrophy -- Development and progression, Lipodystrophy -- Distribution, Lipodystrophy -- Complications and side effects, Lipodystrophy -- Research, HIV infection -- Care and treatment, HIV infection -- Complications and side effects, HIV infection -- Patient outcomes, HIV infection -- Research, Metabolic diseases -- Development and progression, Metabolic diseases -- Patient outcomes, Metabolic diseases -- Research, Stavudine -- Complications and side effects, Stavudine -- Research, Zidovudine -- Complications and side effects, Zidovudine -- Research, Company distribution practices, Health, Health care industry
Published
2010

2. Abacavir/lamivudine/zidovudine maintenance after standard induction in antiretroviral therapy-naive patients: free randomized trial interim results

Author

Sprenger, Herman G., Langebeek, Nienke, Mulder, Paul G.H., Napel, Chris H.H. Ten, Vriesendorp, Robert, Hoepelman, Andy I.M., Legrand, Jean-Claude, Koopmans, Peter P., Van Kasteren, Marjo E.E., Bravenboer, Bert, Kate, Reinier W. Ten, Groeneveld, Paul H.P., van der Werf, Tjip S., Gisolf, Elisabeth H., and Richter, Clemens

Subjects
Abacavir -- Dosage and administration, Abacavir -- Complications and side effects, Lamivudine -- Dosage and administration, Lamivudine -- Complications and side effects, Zidovudine -- Dosage and administration, Zidovudine -- Complications and side effects, HIV infection -- Drug therapy, Health
Abstract

Maintenance with a triple nucleoside reverse transcriptase Inhibitor (NRTI) regimen after successful induction with a dual NRTI/protease inhibitor (PI) combination may be advantageous, because of low pill burden, favorable lipids, and less drug interactions. This strategy to become free of PI-related problems without losing viral efficacy has not been formally tested. We performed a randomized, open-label, multicenter, 96-week comparative study in antiretroviral therapy (ART)-naive patients with CD4 50 copies per milliliter). Two hundred seven patients had similar baseline (BL) char- acteristics: median CD4 180 cells/[mm.sup.3], median VL 5.19 log10 copies per milliliter. One hundred twenty subjects (58%) met randomization criteria. Baseline VL differed significantly between dropouts and randomized subjects (median 5.41 versus 5.06 log10 copies per milliliter, p = 0.017), as did CD4 cells (median 160 and 200 cells/ram3, p = 0.044). Sixty-one subjects received TZV and 59 subjects continued NRTIs/PI. At week 48, 2 patients in the TZV group and 5 in the PI group did not have a sustained virologic suppression (log rank test; p = 0.379). CD4 counts increased significantly in both arms. In ART-naive patients, TZV maintenance had similar antiviral efficacy compared to continued standard ART at 48 weeks after baseline. Patients on successful standard ART can be safely switched to a NRTI-only regimen, at least for the tested time period. DOI: 10.1089/apc.2009.0236

Published
2010

3. Epidemiological and biological evidence for a compensatory effect of connection domain mutation N348I on M184V in HIV-1 reverse transcriptase

Author

von Wyl, VIktor, Ehteshami, Maryam, Symons, Jori, Burgisser, Philippe, Nijhuis, Monique, Demeter, Lisa M., Yerly, Sabine, Boni, Jurg, Klimkait, Thomas, Schuurman, Rob, Ledergerber, Bruno, Gotte, Matthias, and Gunthard, Huldrych F.

Subjects
Gene mutations -- Research, Reverse transcriptase -- Genetic aspects, Reverse transcriptase -- Research, HIV infection -- Genetic aspects, HIV infection -- Research, Zidovudine -- Dosage and administration, Zidovudine -- Complications and side effects, Lamivudine -- Dosage and administration, Lamivudine -- Complications and side effects, Drug resistance in microorganisms -- Genetic aspects, Drug resistance in microorganisms -- Research, Health
Published
2010

4. Severe transient neonatal lactic acidosis during prophylactic zidovudine treatment

Author

Scalfaro, P., Chesaux, J.J., Buchwalder, P.A., Biollaz, J., and Micheli, J.L.

Subjects
Lactic acidosis -- Risk factors, Zidovudine -- Complications and side effects, Infants (Newborn) -- Diseases, Infants (Newborn) -- Drug therapy, Health care industry
Abstract

Byline: P. Scalfaro (1), J. J. Chesaux (2), P. A. Buchwalder (3), J. Biollaz (3), J. L. Micheli (1) Keywords: Key words HIV infection; Zidovudine; Neonate; Prophylaxis; Lactic acidosis Abstract: Zidovudine (ZDV) treatment during pregnancy, delivery and the postnatal period is effective in reducing the maternal-infant transmission of the human immunodeficiency virus. Reported adverse effects in the neonate during this long-term treatment are bone marrow suppression and elevation in aspartate aminotransferase activity. We report a case of severe ZDV-associated lactic acidosis in a neonate, which resolved rapidly following discontinuation of ZDV. The mechanisms leading to this side effect are poorly understood. Author Affiliation: (1) Division of Neonatology, University Hospital, CH-1011 Lausanne, Switzerland, CH (2) Department of Paediatrics, University Hospital, CH-1011 Lausanne, Switzerland, CH (3) Division of Clinical Pharmacology, University Hospital, CH-1011 Lausanne, Switzerland, CH (4) Telethon Institute for Child Health Research, Princess Margaret Hospital for Children, P.O.Box 855, West Perth WA 6872, Australia Fax: +61 (8) 9388 34 14 email: pietros @ ichr.uwa.edu.au, AU Article note: Received: 26 June 1997 Accepted: 1 December 1997

Published
1998

5. Lactic acidosis in HIV infected patients: a systematic review of published cases

Author

Arenas-Pinto, A, Grant, AD, Edwards, S, and Weller, IVD

Subjects
Zidovudine -- Complications and side effects, HIV patients -- Physiological aspects -- Chemical properties, Lactic acidosis -- Risk factors -- Complications and side effects, Health
Abstract

Objective: To describe the clinical, epidemiological, and biochemical characteristics of published cases of lactic acidosis (LA) and to generate hypotheses concerning risk factors associated with this complication. Methods: Systematic review [...]

Published
2003

6. Lamivudine can heighten transplacental zidovudine toxicity

Author

Greer, Michael

Subjects
Zidovudine -- Complications and side effects, Lamivudine -- Complications and side effects, Antiviral agents -- Complications and side effects, Drug interactions -- Health aspects
Abstract

2002 JUN 6 - (NewsRx.com & NewsRx.net) -- by Michael Greer, senior medical writer - The antiretroviral agent lamivudine may increase the toxicity of zidovudine when the two drugs are [...]

Published
2002

7. Rethinking AZT; HIV experts finally admit their deadly drugs sometimes do more harm than good

Author

Ko, Marnie

Subjects
Zidovudine -- Complications and side effects, HIV patients -- Care and treatment -- Drug therapy, HIV infection -- Drug therapy -- Care and treatment -- Complications and side effects, General interest, News, opinion and commentary
Abstract

Christine Maggiore still remembers the day her life changed forever. During a routine 1992 visit to the gynecologist she was offered an HIV test. She thought little of it until [...]

Published
2001

8. Risk of death or HIV infection similar for two infant feeding regimens

Author

London, S.

Subjects
Zidovudine -- Complications and side effects, Infants -- Health aspects, HIV infection -- Health aspects -- Risk factors -- Complications and side effects, Family and marriage, Health, Complications and side effects, Risk factors, Health aspects
Abstract

Among babies born to HIV-infected mothers, those who are fed breast milk and given zidovudine for the first six months of life have a risk of dying or contracting HIV [...]

Published
2006

10. HIV & Pregnancy. (Shorts)

Author

Klotter, Jule

Subjects
Infants -- Patient outcomes, Pregnancy, Mortality -- United States, Zidovudine -- Complications and side effects, HIV infection in children -- Prevention -- Patient outcomes -- Complications and side effects, HIV infection -- Patient outcomes -- Complications and side effects -- Prevention, Health
Abstract

The US Public Health Service policy for treating HIV-positive, pregnant women includes anti-HIV drugs during pregnancy and intravenous AZT (azidothymidine, aka zidovudine or Retrovir) during labor. Their newborns are given [...]

Published
2002

11. Abstract & commentary: thinner: trying to solve the lipoatrophy puzzle

Author

Winslow, Dean L.

Subjects
Stavudine -- Reports, Stavudine -- Dosage and administration, Stavudine -- Complications and side effects, Zidovudine -- Dosage and administration, Zidovudine -- Complications and side effects, Zidovudine -- Reports, Lipodystrophy -- Development and progression, AIDS treatment -- Complications and side effects, AIDS treatment -- Patient outcomes, Health
Abstract

Thinner: Trying to solve the lipoatrophy puzzle 'A visual reminder of HIV-positive status' By Dean L. Winslow, MD, FACP, FIDSA, Chief, Division of AIDS Medicine, Santa Clara Valley, Medical Center; [...]

Published
2010

12. Trizivir

Subjects
Trizivir (Medication) -- Complications and side effects, Trizivir (Medication) -- Dosage and administration, Abacavir -- Dosage and administration, Abacavir -- Complications and side effects, Drug therapy, Combination -- Health aspects, HIV infection -- Drug therapy, Lamivudine -- Dosage and administration, Lamivudine -- Complications and side effects, Zidovudine -- Dosage and administration, Zidovudine -- Complications and side effects
Published
2008

13. Retrovir

Subjects
Retrovir (Medication) -- Dosage and administration, Retrovir (Medication) -- Complications and side effects, HIV infection -- Drug therapy, Zidovudine -- Dosage and administration, Zidovudine -- Complications and side effects
Published
2008

14. Combivir

Subjects
Combivir (Medication) -- Complications and side effects, Combivir (Medication) -- Dosage and administration, AIDS (Disease) -- Drug therapy, Lamivudine -- Dosage and administration, Lamivudine -- Complications and side effects, Zidovudine -- Dosage and administration, Zidovudine -- Complications and side effects
Published
2008

15. Research from National Institute of Health Science provides new data about adverse drug reactions

Subjects
United States. National Institutes of Health -- Reports, Divalproex -- Complications and side effects, Divalproex -- Reports, Valproic acid -- Complications and side effects, Valproic acid -- Reports, Zidovudine -- Complications and side effects, Zidovudine -- Reports
Abstract

Current study results from the report, "Adverse events caused by drug interactions involving glucuronoconjugates of zidovudine, valproic acid and lamotrigine, and analysis of how such potential events are discussed in [...]

Published
2007

16. Sobering Up About AIDS

Author

Cowley, Geoffrey, Rogers, Adam, and Westley, Marian

Subjects
Protease inhibitors -- Complications and side effects, Zidovudine -- Complications and side effects, AIDS (Disease) -- Drug therapy -- Complications and side effects, General interest, News, opinion and commentary
Abstract

Two years ago a cure seemed close at hand. But the new drugs are less potent, and more toxic, than they looked. REMEMBER THE EUPHORIA OF 1996? A new generation [...]

Published
1998

17. Mitochondrial Disease Can be Byproduct of Zidovudine During Pregnancy

Subjects
Pregnancy, Birth defects -- Risk factors -- Complications and side effects, Zidovudine -- Complications and side effects, HIV infection in pregnancy, HIV infection -- Risk factors -- Complications and side effects, Health
Abstract

2000 AUG 1 - (NewsRx.com) -- Zidovudine (ZDV) treatment during pregnancy of HIV infected women may damage fetal mitochondria, researchers in Italy reported. 'Mitochondrial disease is a possible side effect [...]

Published
2000

18. Reversible Cardiac Dysfunction Seen in Children Taking Zidovudine

Subjects
Children's Hospital National Medical Center -- Reports, HIV infection in children -- Complications and side effects, Zidovudine -- Complications and side effects, Virus research -- Reports, United States. National Institutes of Health -- Reports
Abstract

2000 MAY 16 - (NewsRx.com) -- A study prepared by scientists at the Children's National Medical Center in Washington, DC, and the U.S. National Institutes of Health has found that [...]

Published
2000

19. Mitochondrial Dysfunction Linked to Zidovudine Exposure in Children

Subjects
HIV infection in children -- Prevention -- Complications and side effects, Zidovudine -- Complications and side effects, Mitochondria
Abstract

(NewsRx.com) -- Although current recommendations for zidovudine monotherapy should be maintained, the toxic effects should be assessed further, researchers from France indicated. Zidovudine frequently is administered during pregnancy to prevent [...]

Published
1999

20. AZT, d4T Ok'd for infants

Subjects
HIV infection -- Drug therapy, Stavudine -- Dosage and administration, Stavudine -- Complications and side effects, Zidovudine -- Dosage and administration, Zidovudine -- Complications and side effects, Health
Abstract

AZT, d4T OKEd for infants At the same time a blue-ribbon panel found that the benefits of zidovudine (AZT) therapy for HIV-positive pregnant women and their babies outweigh the risk, [...]

Published
1997

21. Maternal AZT linked to cancer in mouse, monkey studies

Author

DeNoon, Daniel J.

Subjects
Zidovudine -- Complications and side effects, Cancer -- Risk factors -- Complications and side effects, Health, Complications and side effects, Risk factors
Abstract

Maternal use of zidovudine (AZT) during pregnancy protects children against HIV transmission but may cause cancer later in life, animal studies suggest. A National Institutes of Health (NIH) panel concluded [...]

Published
1997

22. Brain biopsy may help diagnosis

Author

Cotton, Paul

Subjects
Muscle diseases -- Causes of -- Complications and side effects -- Diagnosis, Zidovudine -- Complications and side effects, Brain -- Biopsy, Antiviral agents -- Complications and side effects, Biopsy, AIDS (Disease) -- Diagnosis -- Complications and side effects
Abstract

Brain Biopsy May Help Diagnosis The procedure, made much less complex by new techniques, is often needed to establish a precise diagnosis, which could have `significant impact' on treatment and [...]

Published
1989

23. Hormone produced by kidney may boost red blood cell counts

Author

Cooper, Mike

Subjects
Anemia -- Drug therapy -- Complications and side effects, Erythropoietin -- Health aspects, Zidovudine -- Complications and side effects, AIDS (Disease) -- Complications and side effects -- Drug therapy
Abstract

Vanderbilt University Researchers Mark Koury and Maurice Bondurant of Vanderbilt University Medical Center, Nashville, report in Science, that erythropoietin (EPO), a hormone produced by the kidney, may boost red blood [...]

Published
1990

24. Extrapulmonary pneumocystis in patients taking aerosolised pentamidine

Author

DeNoon, Daniel J.

Subjects
Pentamidine isethionate -- Complications and side effects, Zidovudine -- Complications and side effects, Pneumocystis carinii pneumonia -- Diagnosis -- Complications and side effects, Pneumocystis carinii -- Diagnosis, AIDS (Disease) -- Diagnosis -- Complications and side effects
Abstract

SOURCE: The Lancet, December 16, 1989; i(8677):1454. A letter by Donald W. Northfelt of San Francisco General Hospital suggests that extrapulmonary pneumocystosis may emerge as a more serious AIDS-associated infection [...]

Published
1990

25. Methadone interacts with common HIV drug

Subjects
Zidovudine -- Complications and side effects, HIV patients, Methadone hydrochloride -- Complications and side effects, Government, Health, Psychology and mental health
Abstract

HIV-positive patients who are simultaneously receiving treatment with methadone and the AIDS drug zidovudine may be at risk of exposure to high levels of zidovudine and subsequent side effects, according [...]

Published
1998

26. Effect of treatment with zidovudine on subsequent incidence of Kaposi's sarcoma

Author

Joffe, M.M., Hoover, D.R., Jacobson, L.P., Kingsley, L., Chmiel, J.S., and Visscher, B.R.

Subjects
Kaposi's sarcoma -- Risk factors -- Complications and side effects, Zidovudine -- Complications and side effects, AIDS (Disease) -- Complications and side effects -- Risk factors, Health, Complications and side effects, Risk factors
Abstract

According to the authors' abstract of an article published in Clinical Infec- tious Diseases, 'Despite much investigation of zidovudine, little has been reported regarding its effect on the development of [...]

Published
1998

27. AZT does not appear to predispose toward NHL

Subjects
Complications and side effects, Risk factors, Non-Hodgkin lymphomas -- Risk factors -- Complications and side effects, AIDS (Disease) -- Risk factors -- Complications and side effects, Zidovudine -- Complications and side effects, Non-Hodgkin's lymphomas -- Risk factors -- Complications and side effects
Abstract

A correspondence from the U.S. National Cancer Institute's AIDS/Cancer Study Group finds that zidovudine does not cause non- Hodgkin's lymphoma in AIDS patients. Zidovudine has been used since 1987 in [...]

Published
1995

28. Vaginal epithelial DNA damage and expression of prenoplastic markers in mice during chronic dosing with tumorigenic levels of 3'-azido-2',3'-dideoxythymidine

Author

Olivero, O.A., Beland, F.A., Fullerton, N.F., and Poirer, M.C.

Subjects
Complications and side effects, Causes of, Epithelial tumors -- Causes of -- Complications and side effects, Zidovudine -- Complications and side effects, Carcinogenesis -- Causes of -- Complications and side effects
Abstract

According to the authors' abstract of an article published in Cancer Research, '3'-Azido-2',3'-dideoxythymidine (AZT, Retrovir, zidovudine), a nucleoside analogue currently used in the therapy of acquired immunodeficiency syndrome, induces papillomas [...]

Published
1995

29. AZT causes cancer in lab animals

Subjects
Zidovudine -- Complications and side effects, Cancer -- Causes of -- Complications and side effects -- Drug therapy, AIDS (Disease) -- Drug therapy -- Complications and side effects, Science and technology
Abstract

AZT causes cancer in lab animals Investigators last week reported finding vaginal cancer in mice and rats given high doses of zidovudine (AZT), the only federally approved drug that attacks [...]

Published
1989

30. Long term (17 months) nailbed discoloration during Retrovir (AZT) use with no deleterious outcome

Author

Scarpinato, L., Eshraghi, K., and Oleson, G.

Subjects
Retrovir (Medication) -- Complications and side effects, Zidovudine -- Complications and side effects, AIDS (Disease) -- Drug therapy -- Complications and side effects
Abstract

AUTHORS: L. Scarpinato, K. Eshraghi and G. Oleson. University of Missouri-Kansas City School of Medicine, Truman Medical Center East, Kansas City, Mo. According to the abstract submitted by the authors [...]

Published
1990

31. Azidothymidine (AZT) at therapeutic doses produces unusual dense macrolytic red cells

Author

DeNoon, Daniel J. and Cooper, Mike

Subjects
Zidovudine -- Complications and side effects, Antiviral agents -- Complications and side effects, Erythrocytes -- Abnormalities, AIDS (Disease) -- Drug therapy -- Complications and side effects
Abstract

AUTHORS: E.F. Roth Jr., G.H. Friedland, M.E. Fabry, and R.L. Nagel. Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, N.Y. According to the abstract of the authors' presentation to American [...]

Published
1990

32. FDA permits distribution of experimental drug

Subjects
Government regulation, Anemia -- Drug therapy -- Complications and side effects, Erythropoietin -- Laws, regulations and rules, Zidovudine -- Complications and side effects, AIDS (Disease) -- Drug therapy -- Complications and side effects, United States. Food and Drug Administration -- Laws, regulations and rules
Abstract

U.S. Department of Health and Human Services FDA PERMITS DISTRIBUTION OF EXPERIMENTAL DRUG HHS Secretary Louis W. Sullivan, M.D., announced that the Food and Drug Administration is permitting expanded premarket [...]

Published
1989

33. Zidovudine in symptomless HIV infection

Author

DeNoon, Daniel J.

Subjects
Zidovudine -- Complications and side effects, AIDS (Disease) -- Drug therapy -- Complications and side effects
Abstract

'Zidovudine in Symptomless HIV Infection' In an editorial, the editors of The Lancet note that as administration of zidovudine (AZT) to asymptomatic patients risks significant toxicity and viral resistance, the [...]

Published
1989

34. Myopathy associated with HIV infection and zidovudine therapy

Author

Cooper, Mike and DeNoon, Daniel J.

Subjects
Muscle diseases -- Causes of -- Drug therapy -- Complications and side effects, Zidovudine -- Complications and side effects, AIDS (Disease) -- Drug therapy -- Complications and side effects
Abstract

'Myopathy Associated with HIV Infection and Zidovudine Therapy.' According to the abstract submitted by the authors to the Central Society for Clinical Research meeting in Chicago, 'Three HIV-infected men developed [...]

Published
1989

Catalog

Books, media, physical & digital resources
See catalog results