14 results on '"Zicchetti, Mabel"'
Search Results
2. Reproducibility of real-time shear wave elastography in the evaluation of liver elasticity
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Ferraioli, Giovanna, Tinelli, Carmine, Zicchetti, Mabel, Above, Elisabetta, Poma, Gianluigi, Di Gregorio, Marta, and Filice, Carlo
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- 2012
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3. Interobserver reproducibility of the controlled attenuation parameter (CAP) for quantifying liver steatosis
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Ferraioli, Giovanna, Tinelli, Carmine, Lissandrin, Raffaella, Zicchetti, Mabel, Rondanelli, Mariangela, Perani, Guido, Bernuzzi, Stefano, Salvaneschi, Laura, and Filice, Carlo
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- 2014
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4. Ultrasound point shear wave elastography assessment of liver and spleen stiffness: effect of training on repeatability of measurements
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Ferraioli, Giovanna, Tinelli, Carmine, Lissandrin, Raffaella, Zicchetti, Mabel, Bernuzzi, Stefano, Salvaneschi, Laura, Filice, Carlo, and on behalf of the Elastography Study Group
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- 2014
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5. Accuracy of real-time shear wave elastography for assessing liver fibrosis in chronic hepatitis C: A pilot study
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Ferraioli, Giovanna, Tinelli, Carmine, Dal Bello, Barbara, Zicchetti, Mabel, Filice, Gaetano, and Filice, Carlo
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- 2012
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6. Assessment of liver stiffness with transient elastography by using S and M probes in healthy children
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Ferraioli, Giovanna, Lissandrin, Raffaella, Zicchetti, Mabel, and Filice, Carlo
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- 2012
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7. Internistic onset of a psychiatric disease
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Di Toro, Alessandro, Zicchetti, Mabel, Mereu, Roberto, Mondellini, Luisa, Messa, Gabriella, Perrone, Tiziano, and Mugellini, Amedeo
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nutritional and metabolic diseases ,macromolecular substances - Abstract
Psychogenic polydipsia is the act of compulsive water drinking. It is a well-recognized phenomenon that occurs in patients with psychiatric diseases, which, when severe enough, can lead to hyponatremia and characterize Self-Induced Water Intoxication (SIWI). SIWI patients present with various neurological findings such as brain edema, coma, convulsion and death due to secondary severe hyponatremia. Non-neurological symptoms, such as rhabdomyolysis, have been rarely described. In this case we will present a patient who presented with severe hyponatremia secondary to psychogenic polydipsia and rhabdomyolysis., Bollettino della Società Medico Chirurgica di Pavia, Vol 124, N° 1 (2011)
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- 2011
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8. A case of suspicious eosinophilia
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Di Toro, Alessandro, Zicchetti, Mabel, Mereu, Roberto, Mondellini, Luisa, Messa, Gabriella, Perrone, Tiziano, and Mugellini, Amedeo
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Strongyloidiasis is a human parasitic disease caused by the nematode Strongyloides stercoralis. It is endemic in the tropical and subtropical regions and infects up to one hundred million people in the world. It is widespread also in Europe and ipoendemic areas in Italy exist. The health consequences of S. stercoralis infections range from asymptomatic light infections to chronic symptomatic strongyloidiasis. We report the case of an elderly woman who had never been in tropical regions and presented with weight loss and asthenia., Bollettino della Società Medico Chirurgica di Pavia, Vol 124, N° 1 (2011)
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- 2011
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9. An unusual hypertension case
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Di Toro, Alessandro, Mereu, Roberto, Zicchetti, Mabel, Mondellini, Luisa, Messa, Gabriella, Perrone, Tiziano, and Mugellini, Amedeo
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urologic and male genital diseases - Abstract
Sclerodermic renal crisis is characterized by hypertension and rapidly progressive renal failure. It occurs in about 10% of patients with diffuse cutaneous scleroderma and is relatively rare in patients with the limited cutaneous variant. In up to a quarter of patients with sclerodermic renal crisis, the diagnosis of systemic sclerosis is made at the time of the renal presentation. The case that follows shows a renal sclerodermic crisis as beginning of systemic sclerosis., Bollettino della Società Medico Chirurgica di Pavia, Vol 123, N° 4 (2010)
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- 2011
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10. Correlation of the controlled attenuation parameter with indices of liver steatosis in overweight or obese individuals
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Ferraioli, Giovanna, primary, Tinelli, Carmine, additional, Lissandrin, Raffaella, additional, Zicchetti, Mabel, additional, Faliva, Milena, additional, Perna, Simone, additional, Perani, Guido, additional, Alessandrino, Francesco, additional, Calliada, Fabrizio, additional, Rondanelli, Mariangela, additional, and Filice, Carlo, additional
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- 2015
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11. Controlled attenuation parameter for evaluating liver steatosis in chronic viral hepatitis.
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Ferraioli G, Tinelli C, Lissandrin R, Zicchetti M, Dal Bello B, Filice G, and Filice C
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- Adult, Area Under Curve, Biopsy, Cross-Sectional Studies, Fatty Liver complications, Female, Hepatitis C, Chronic complications, Humans, Linear Models, Liver diagnostic imaging, Male, Middle Aged, Multivariate Analysis, Predictive Value of Tests, Prospective Studies, Sensitivity and Specificity, Ultrasonography, Fatty Liver physiopathology, Hepatitis C, Chronic diagnosis, Hepatitis C, Chronic physiopathology
- Abstract
Aim: To assess the performance of controlled attenuation parameter (CAP) in patients with chronic viral hepatitis., Methods: CAP is a new technique that measures the attenuation in the liver of an ultrasound beam, which is directly related to lipid accumulation. Consecutive patients undergoing liver biopsy for chronic viral hepatitis were studied using the M probe of FibroScan device (Echosens, Paris, France). The device estimates liver steatosis in decibel per meter (dB/m). An expert operator performed all measurements. Steatosis was graded according to Kleiner's classification. Pearson or Spearman rank coefficient was used to test correlation between two study variables. Linear regression was used for multivariate model to assess the association between CAP and other variables. Receiver operating characteristic curve analysis was performed to calculate area under the curve (AUROC) for S0 vs S1-S3 and S0-S1 vs S2-S3., Results: 115 subjects (85 males and 30 females) were prospectively studied. The mean values of CAP were 227.1 ± 43.1 for S0; 254.6 ± 38.9 for S1; 297.8 ± 49.4 dB/m for S2-S3. In univariate analysis CAP showed a significant correlation with age, body mass index (BMI), degree of steatosis, and cholesterol. Multivariate regression analysis confirmed the correlation with the degree of steatosis [coefficient, 1.2 (0.60-1.83); P < 10(-5)] and BMI [coefficient, 4.1 (0.5-7.8); P = 0.03] but not with all other variables. Optimal cutoff values for S ≥ 1 and S ≥ 2 were 219 dB/m [AUROC, 0.76 (0.67-0.84); sensitivity, 91.1% (78.8-97.5); specificity, 51.6% (38.7-64.2); positive predictive value, 56.9% (44.7-68.6); negative predictive value, 89.2% (74.3-97.0); positive likelihood ratio, 1.88 (1.4-2.5); negative likelihood ratio, 0.17 (0.07-0.5)] and 296 dB/m [AUROC, 0.82 (0.74-0.89); sensitivity, 60.0% (32.3-83.7); specificity, 91.5% (83.9-96.3); positive predictive value, 52.9% (27.8-77.0); negative predictive value, 93.5% (86.3-97.6); positive likelihood ratio, 7.05 (3.2-15.4); negative likelihood ratio, 0.44 (0.2-0.8)], respectively., Conclusion: Controlled attenuation parameter could be a useful tool in the clinical management of patients with chronic viral hepatitis for detecting liver steatosis.
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- 2014
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12. Point shear wave elastography method for assessing liver stiffness.
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Ferraioli G, Tinelli C, Lissandrin R, Zicchetti M, Dal Bello B, Filice G, and Filice C
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- Adult, Area Under Curve, Biopsy, Case-Control Studies, Cross-Sectional Studies, Elasticity, Female, Hepatitis C, Chronic pathology, Humans, Italy, Liver pathology, Liver Cirrhosis pathology, Liver Cirrhosis virology, Male, Middle Aged, Observer Variation, Predictive Value of Tests, ROC Curve, Reproducibility of Results, Severity of Illness Index, Elasticity Imaging Techniques methods, Hepatitis C, Chronic diagnostic imaging, Liver diagnostic imaging, Liver Cirrhosis diagnostic imaging
- Abstract
Aim: To estimate the validity of the point shear-wave elastography method by evaluating its reproducibility and accuracy for assessing liver stiffness., Methods: This was a single-center, cross-sectional study. Consecutive patients with chronic viral hepatitis scheduled for liver biopsy (LB) (Group 1) and healthy volunteers (Group 2) were studied. In each subject 10 consecutive point shear-wave elastography (PSWE) measurements were performed using the iU22 ultrasound system (Philips Medical Systems, Bothell, WA, United States). Patients in Group 1 underwent PSWE, transient elastography (TE) using FibroScan (Echosens, Paris, France) and ultrasound-assisted LB. For the assessment of PSWE reproducibility two expert raters (rater 1 and rater 2) independently performed the examinations. The performance of PSWE was compared to that of TE using LB as a reference standard. Fibrosis was staged according to the METAVIR scoring system. Receiver operating characteristic curve analyses were performed to calculate the area under the receiver operating characteristic curve (AUC) for F ≥ 2, F ≥ 3 and F = 4. The intraobserver and interobserver reproducibility of PSWE were assessed by calculating Lin's concordance correlation coefficient., Results: To assess the performance of PSWE, 134 consecutive patients in Group 1 were studied. The median values of PSWE and TE (in kilopascals) were 4.7 (IQR = 3.8-5.4) and 5.5 (IQR = 4.7-6.5), respectively, in patients at the F0-F1 stage and 3.5 (IQR = 3.2-4.0) and 4.4 (IQR = 3.5-4.9), respectively, in the healthy volunteers in Group 2 (P < 10(-5)). In the univariate analysis, the PSWE and TE values showed a high correlation with the fibrosis stage; low correlations with the degree of necroinflammation, aspartate aminotransferase and gamma-glutamyl transferase (GGT); and a moderate negative correlation with the platelet count. A multiple regression analysis confirmed the correlations of both PSWE and TE with fibrosis stage and GGT but not with any other variables. The following AUC values were found: 0.80 (0.71-0.87) for PSWE and 0.82 (0.73-0.89) for TE (P = 0.42); 0.88 (0.80-0.94) for PSWE and 0.95 (0.88-0.98) for TE (P = 0.06); and 0.95 (0.89-0.99) for PSWE and 0.92 (0.85-0.97) for TE (P = 0.30) for F ≥ 2, F ≥ 3 and F = 4, respectively. To assess PSWE reproducibility, 116 subjects were studied, including 47 consecutive patients scheduled for LB (Group 1) and 69 consecutive healthy volunteers (Group 2). The intraobserver agreement ranged from 0.83 (95%CI: 0.79-0.88) to 0.96 (95%CI: 0.95-0.97) for rater 1 and from 0.84 (95%CI: 0.79-0.88) to 0.96 (95%CI: 0.95-0.97) for rater 2. The interobserver agreement yielded values from 0.83 (95%CI: 0.78-0.88) to 0.93 (95%CI: 0.91-0.95)., Conclusion: PSWE is a reproducible method for assessing liver stiffness, and it compares with TE. Compared with patients with nonsignificant fibrosis, healthy volunteers showed significantly lower values.
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- 2014
- Full Text
- View/download PDF
13. Performance of liver stiffness measurements by transient elastography in chronic hepatitis.
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Ferraioli G, Tinelli C, Dal Bello B, Zicchetti M, Lissandrin R, Filice G, Filice C, Above E, Barbarini G, Brunetti E, Calderon W, Di Gregorio M, Gulminetti R, Lanzarini P, Ludovisi S, Maiocchi L, Malfitano A, Michelone G, Minoli L, Mondelli M, Novati S, Patruno SF, Perretti A, Poma G, Sacchi P, Zanaboni D, and Zaramella M
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- Adult, Biopsy, Cross-Sectional Studies, Elasticity Imaging Techniques standards, Female, Hepatitis B, Chronic complications, Hepatitis C, Chronic complications, Humans, Liver Cirrhosis complications, Liver Cirrhosis pathology, Male, Middle Aged, ROC Curve, Regression Analysis, Elasticity Imaging Techniques methods, Hepatitis B, Chronic physiopathology, Hepatitis C, Chronic physiopathology, Liver pathology
- Abstract
Aim: To compare results of liver stiffness measurements by transient elastography (TE) obtained in our patients population with that used in a recently published meta-analysis., Methods: This was a single center cross-sectional study. Consecutive patients with chronic viral hepatitis scheduled for liver biopsy at the outpatient ward of our Infectious Diseases Department were enrolled. TE was carried out by using FibroScan™ (Echosens, Paris, France). Liver biopsy was performed on the same day as TE, as day case procedure. Fibrosis was staged according to the Metavir scoring system. The diagnostic performance of TE was assessed by using receiver operating characteristic (ROC) curves and the area under the ROC curve analysis., Results: Two hundred and fifty-two patients met the inclusion criteria. Six (2%) patients were excluded due to unreliable TE measurements. Thus, 246 (171 men and 75 women) patients were analyzed. One hundred and ninety-five (79.3%) patients had chronic hepatitis C, 41 (16.7%) had chronic hepatitis B, and 10 (4.0%) were coinfected with human immunodeficiency virus. ROC curve analysis identified optimal cut-off value of TE as high as 6.9 kPa for F ≥ 2; 7.9 kPa for F ≥ 3; 9.6 kPa for F = 4 in all patients (n = 246), and as high as 6.9 kPa for F ≥ 2; 7.3 kPa for F ≥ 3; 9.3 kPa for F = 4 in patients with hepatitis C (n = 195). Cut-off values of TE obtained by maximizing only the specificity were as high as 6.9 kPa for F ≥ 2; 9.6 kPa for F ≥ 3; 12.2 kPa for F = 4 in all patients (n = 246), and as high as 7.0 kPa for F ≥ 2; 9.3 kPa for F ≥ 3; 12.3 kPa for F = 4 in patients with hepatitis C (n = 195)., Conclusion: The cut-off values of TE obtained in this single center study are comparable to that obtained in a recently published meta-analysis that included up to 40 studies.
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- 2013
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14. Performance of real-time strain elastography, transient elastography, and aspartate-to-platelet ratio index in the assessment of fibrosis in chronic hepatitis C.
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Ferraioli G, Tinelli C, Malfitano A, Dal Bello B, Filice G, Filice C, Above E, Barbarini G, Brunetti E, Calderon W, Di Gregorio M, Lissandrin R, Ludovisi S, Maiocchi L, Michelone G, Mondelli M, Patruno SF, Perretti A, Poma G, Sacchi P, Zaramella M, and Zicchetti M
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- Adult, Area Under Curve, Biopsy, Blood Platelets metabolism, Disease Progression, Female, Follow-Up Studies, Humans, Liver Cirrhosis etiology, Liver Cirrhosis pathology, Male, Middle Aged, Prospective Studies, ROC Curve, Sensitivity and Specificity, Aspartic Acid blood, Elasticity Imaging Techniques, Hepatitis C, Chronic complications, Liver diagnostic imaging, Liver pathology, Liver Cirrhosis blood, Liver Cirrhosis diagnostic imaging
- Abstract
Objective: The purpose of this article is to evaluate the diagnostic performance of transient elastography, real-time strain elastography, and aspartate-to-platelet ratio index in assessing fibrosis in patients with chronic hepatitis C by using histologic Metavir scores as reference standard., Subjects and Methods: Consecutive patients with chronic hepatitis C scheduled for liver biopsy were enrolled. Liver biopsy was performed on the same day as transient elastography and real-time strain elastography. Transient elastography and real-time strain elastography were performed in the same patient encounter by a single investigator using a medical device based on elastometry and an ultrasound machine, respectively. Diagnostic performance was assessed by using receiver operating characteristic curves and area under the receiver operating characteristic curve (AUC) analysis., Results: One hundred thirty patients (91 men and 39 women) were analyzed. The cutoff values for transient elastography, real-time strain elastography, and aspartate-to-platelet ratio index were 6.9 kPa, 1.82, and 0.37, respectively, for fibrosis score of 2 or higher; 7.3 kPa, 1.86, and 0.70, respectively, for fibrosis score of 3 or higher; and 9.3 kPa, 2.33, and 0.70, respectively, for fibrosis score of 4. AUC values of transient elastography, real-time strain elastography, aspartate-to-platelet ratio index were 0.88, 0.74, and 0.86, respectively, for fibrosis score of 2 or higher; 0.95, 0.80, and 0.89, respectively, for fibrosis score of 3 or higher; and 0.97, 0.80, and 0.84, respectively, for fibrosis score of 4. A combination of the three methods, when two of three were in agreement, showed AUC curves of 0.93, 0.95, and 0.95 for fibrosis scores of 2 or higher, 3 or higher, and 4, respectively., Conclusion: Transient elastography, real-time strain elastography, and aspartate-to-platelet ratio index values were correlated with histologic stages of fibrosis. Transient elastography offered excellent diagnostic performance in assessing severe fibrosis and cirrhosis. Real-time elastography does not yet have the potential to substitute for transient elastography in the assessment of liver fibrosis.
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- 2012
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