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189 results on '"Zhu, Ying‐Hui"'

13. Supplementary Methods, Figure Legends, and Tables 1 - 5 from Downregulation of the Novel Tumor Suppressor DIRAS1 Predicts Poor Prognosis in Esophageal Squamous Cell Carcinoma

Author

Zhu, Ying-Hui, primary, Fu, Li, primary, Chen, Leilei, primary, Qin, Yan-Ru, primary, Liu, Haibo, primary, Xie, Fajun, primary, Zeng, Tingting, primary, Dong, Sui-Sui, primary, Li, Jiangchao, primary, Li, Yan, primary, Dai, Yongdong, primary, Xie, Dan, primary, and Guan, Xin-Yuan, primary

Published
2023
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32. Is Leg-Driven Treadmill-Based Exoskeleton Robot Training Beneficial to Poststroke Patients: A Systematic Review and Meta-analysis.

Author

Zhu, Ying-Hui, Ruan, Ming, Yun, Rui-Sheng, Zhong, Ying-Xi, Zhang, Yu-Xin, Wang, Yong-Jun, Sun, Yue-Li, and Cui, Jia-Wen

Subjects
*EVALUATION of medical care, *ONLINE information services, *MEDICAL databases, *ROBOTIC exoskeletons, *NEUROLOGICAL disorders, *META-analysis, *MEDICAL information storage & retrieval systems, *SYSTEMATIC reviews, *GAIT in humans, *POSTURAL balance, *TREADMILLS, *EXERCISE physiology, *ROBOTICS, *GAIT disorders, *STROKE patients, *DIAGNOSIS, *DESCRIPTIVE statistics, *MEDLINE, *DATA analysis software
Abstract

Objective: The aim of the study is to systematically review the effects of leg-driven treadmill-based exoskeleton robot training on balance and walking ability in poststroke patients. Design: The PubMed, Cochrane Library, Embase, Web of Science, Medline, CNKI, VIP, and Wanfang databases were searched from inception to August 2021. The literature quality was evaluated using Cochrane Handbook. Primary outcomes include the Functional Ambulation Category Scale and Berg Balance Scale, and secondary outcomes include the 10 meter walk test, 6 minute walk test, and gait assessment cadence were analyzed. Results: Seventeen randomized controlled trials were included in the systematic review, 15 studies in meta-analysis. Primary outcomes showed no significant difference in the Functional Ambulation Category Scale score; subgroup with the exoskeleton robot + conventional therapy of the Berg Balance Scale score was significantly increased; secondary outcomes showed no significance in 6 minute walk test or 10 meter walk test. The cadence score increased for the subgroup with an onset of more than 6 mos in the treatment group. The control group performed better than the subgroup with an onset of less than 6 mos. Conclusions: Leg-driven treadmill-based exoskeleton robot training can improve balance function in poststroke patients and is beneficial for patients with an onset of greater than 6 mos. However, there is no evidence to support the efficacy of walking ability. [ABSTRACT FROM AUTHOR]

Published
2023
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41. Tumor Fibroblast–Derived FGF2 Regulates Expression of SPRY1 in Esophageal Tumor–Infiltrating T Cells and Plays a Role in T-cell Exhaustion

Author

Chen, Qing-yun, primary, Li, Yi-ni, additional, Wang, Xin-yue, additional, Zhang, Xu, additional, Hu, Yi, additional, Li, Lei, additional, Suo, Da-qin, additional, Ni, Ke, additional, Li, Zhuo, additional, Zhan, Jia-rong, additional, Zeng, Ting-ting, additional, Zhu, Ying-hui, additional, Li, Yan, additional, Ma, Li-jia, additional, and Guan, Xin-Yuan, additional

Published
2020
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46. Overexpression of ubiquitin specific peptidase 14 predicts unfavorable prognosis in esophageal squamous cell carcinoma

Author

Zhang, Baozhu, Li, Mengqing, Huang, Pinzhu, Guan, Xin‐Yuan, and Zhu, Ying‐Hui

Subjects
Male, Esophageal Neoplasms, ESCC, Original Articles, Kaplan-Meier Estimate, Prognosis, USP14, Up-Regulation, Gene Expression Regulation, Neoplastic, Cell Line, Tumor, Carcinoma, Squamous Cell, Humans, Original Article, Female, Esophageal Squamous Cell Carcinoma, Neoplasm Metastasis, Ubiquitin Thiolesterase, Neoplasm Staging
Abstract

Background Ubiquitin specific peptidase 14 (USP14), a deubiquitinating enzyme, has been documented as a key element to regulate the proteolysis function of proteasomes and an attractive therapeutic target for several cancers. Herein, we elucidate the role of USP14 in predicting the prognosis of patients with esophageal squamous cell carcinoma (ESCC). Methods USP14 expression was detected in ESCC tissues and matched adjacent non‐tumorous tissues by quantitative real‐time reverse transcription‐PCR and immunohistochemistry. Kaplan–Meier survival analysis was used to assess the correlation between USP14 expression and prognosis in ESCC patients. Univariate and multivariate analysis was conducted with a Cox proportional hazards model to determine whether USP14 is an independent prognostic factor. Result Overexpression of USP14 was observed in approximately 60% of tested ESCC samples compared to their paired non‐tumor esophageal tissues at both RNA and protein levels, and was significantly associated with distant metastasis (P = 0.001). Kaplan–Meier analysis showed that USP14 overexpression was related to poorer overall patient survival. Univariate and multivariate analyses demonstrated that USP14 was an independent risk factor for overall survival. Conclusion The findings in this study suggest that USP14 could be used as a potential prognostic marker for ESCC patients.

Published
2017

47. Adenovirus-mediated delivery of interferon-γ gene inhibits the growth of nasopharyngeal carcinoma

Author

Liu Ran-yi, Zhu Ying-hui, Zhou Ling, Zhao Peng, Li Hong-li, Zhu Lan-cai, Han Hong-yu, Lin Huan-xin, Kang Liang, Wu Jiang-xue, and Huang Wenlin

Subjects
Gene therapy, Interferon-γ, Nasopharyngeal carcinoma, Adenoviral vector, Medicine
Abstract

Abstract Background Interferon-γ (IFN-γ) is regarded as a potent antitumor agent, but its clinical application is limited by its short half-life and significant side effects. In this paper, we tried to develop IFN-γ gene therapy by a replication defective adenovirus encoding the human IFN-γ (Ad-IFNγ), and evaluate the antitumoral effects of Ad-IFNγ on nasopharyngeal carcinoma (NPC) cell lines in vitro and in xenografts model. Methods The mRNA levels of human IFN-γ in Ad-IFNγ-infected NPC cells were detected by reverse transcription-polymerase chain reaction (RT-PCR), and IFN-γ protein concentrations were measured by enzyme-linked immunosorbent assay (ELISA) in the culture supernatants of NPC cells and tumor tissues and bloods of nude mice treated with Ad-IFNγ. The effects of Ad-IFNγ on NPC cell proliferation was determined using MTT assay, cell cycle distribution was determined by flow cytometry analysis for DNA content, and cells apoptosis were analyzed by Annexin V-FITC/7-AAD binding assay and hoechst 33342/PI double staining. The anti-tumor effects and toxicity of Ad-IFNγ were evaluated in BALB/c nude mice carrying NPC xenografts. Results The results demonstrated that Ad-IFNγ efficiently expressed human IFN-γ protein in NPC cell lines in vitro and in vivo. Ad-IFNγ infection resulted in antiproliferative effects on NPC cells by inducing G1 phase arrest and cell apoptosis. Intratumoral administration of Ad-IFNγ significantly inhibited the growth of CNE-2 and C666-1 cell xenografts in nude mice, while no significant toxicity was observed. Conclusions These findings indicate IFN-γ gene therapy mediated by replication defective adenoviral vector is likely a promising approach in the treatment of nasopharyngeal carcinoma.

Published
2012
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48. Role of SIRT1 in hematologic malignancies

Author

Huang, Fei-teng, primary, Sun, Jie, additional, Zhang, Lei, additional, He, Xin, additional, Zhu, Ying-hui, additional, Dong, Hao-jie, additional, Wang, Han-ying, additional, Zhu, Lei, additional, Zou, Jing-ying, additional, Huang, Jin-wen, additional, and Li, Ling, additional

Published
2019
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49. LINC01554-Mediated Glucose Metabolism Reprogramming Suppresses Tumorigenicity in Hepatocellular Carcinoma via Downregulating PKM2 Expression and Inhibiting Akt/mTOR Signaling Pathway

Author

Zheng, Yin-Li, primary, Li, Lei, additional, Jia, Yong-Xun, additional, Zhang, Bao-Zhu, additional, Li, Jiang-Chao, additional, Zhu, Ying-Hui, additional, Li, Meng-Qing, additional, He, Jiao-Zi, additional, Zeng, Ting-Ting, additional, Ban, Xiao-Jiao, additional, Yuan, Yun-Fei, additional, Li, Yan, additional, and Guan, Xin-Yuan, additional

Published
2019
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50. Overexpression of GPR39 contributes to malignant development of human esophageal squamous cell carcinoma

Author

Tang Hong, Nie Changjun, Chen Leilei, Zeng Tingting, Dai Yongdong, Qin Yan-Ru, Zhu Ying-Hui, Liu Haibo, Xie Fajun, Li Yan, Fu Li, and Guan Xin-Yuan

Subjects
Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Background By using cDNA microarray analysis, we identified a G protein-coupled receptor, GPR39, that is significantly up-regulated in ESCC. The aim of this study is to investigate the role of GPR39 in human esophageal cancer development, and to examine the prevalence and clinical significance of GPR39 overexpression in ESCC. Methods The mRNA expression level of GPR39 was analyzed in 9 ESCC cell lines and 50 primary ESCC tumors using semi-quantitative RT-PCR. Immunohistochemistry was used to assess GPR39 protein expression in tissue arrays containing 300 primary ESCC cases. In vitro and in vivo studies were done to elucidate the tumorigenic role of GPR39 in ESCC cells. Results We found that GPR39 was frequently overexpressed in primary ESCCs in both mRNA level (27/50, 54%) and protein level (121/207, 58.5%), which was significantly associated with the lymph node metastasis and advanced TNM stage (P < 0.01). Functional studies showed that GPR39 has a strong tumorigenic ability. Introduction of GPR39 gene into ESCC cell line KYSE30 could promote cell proliferation, increase foci formation, colony formation in soft agar, and tumor formation in nude mice. The mechanism by which amplified GPR39 induces tumorigenesis was associated with its role in promoting G1/S transition via up-regulation of cyclin D1 and CDK6. Further study found GPR39 could enhance cell motility and invasiveness by inducing EMT and remodeling cytoskeleton. Moreover, depletion of endogenous GPR39 by siRNA could effectively decrease the oncogenicity of ESCC cells. Conclusions The present study suggests that GPR39 plays an important tumorigenic role in the development and progression of ESCC.

Published
2011
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