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323 results on '"Zhu, Xiaoqun"'

29. Sensitivity‐Adjustable Flexible Conductors Based on Liquid Metals via Magnetic Printing.

Author

Wang, Keqiang, Lu, Guoqiang, Dong, Shiyu, Yuan, Hengda, Tang, Ruifen, Nie, Jun, and Zhu, Xiaoqun

Subjects
LIQUID metals, FLEXIBLE electronics, ELECTRIC conductivity, ELECTRICAL conductors, SOLID state proton conductors
Abstract

The ability to shape and pattern conductors has been indispensable for manufacturing functional devices. Herein, a series of patterned liquid metals–based flexible electronics are fabricated via magnetic printing. The combination of highly conductive liquid metals and flexible photosensitive resins endows the as‐prepared devices with excellent electrical and mechanical properties, such as high electric conductivity (8 × 104 S m−1), low detection hysteresis, good durability, and environmental stability. What's more, strain‐insensitive flexible electronics can be achieved by designing the structure of liquid metal‐based conductors, and the resistance is only increased 0.13 Ω at 100% strain. Therefore, the as‐prepared liquid metals‐based flexible electronics have promising applications in stretchable conductors. [ABSTRACT FROM AUTHOR]

Published
2024
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43. Brain gray matter volume mediated the relationship between plasma p‐tau and cognition of early Alzheimer’s disease

Author

Wan, Ke, primary, Yin, Wenwen, additional, Tang, Yating, additional, Zhu, Wenhao, additional, Wang, Zhiqiang, additional, Zhou, Xia, additional, Zhang, Wei, additional, Zhang, Cun, additional, Yu, Xianfeng, additional, Li, Chenchen, additional, Zhao, Wenming, additional, Zhu, Xiaoqun, additional, and Sun, Zhongwu, additional

Published
2023
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50. Adult‐onset Krabbe disease due to a homozygous GALC mutation without abnormal signals on an MRI in a consanguineous family: A case report

Author

Zhou Xia, Yin Wenwen, Yu Xianfeng, Hu Panpan, Zhu Xiaoqun, and Sun Zhongwu

Subjects
GALC, grey matter atrophy, Krabbe disease, Genetics, QH426-470
Abstract

Abstract Background The most frequent and common form of Krabbe disease (KD) is early‐onset KD in infants, and late‐onset KD has been reported to be a rare disease. In the present study, we reported an adult‐onset KD patient in a consanguineous Chinese family. Methods Clinical and radiological data were collected for a family pedigree. The patient was diagnosed with late‐onset KD through next‐generation sequencing. The result was confirmed by Sanger sequencing. GALC enzyme activity was also examined by the colorimetry method. Both the grey matter volume (GMV) and white matter volume values were examined and compared with the average values from ten age‐matched normal controls. Moreover, we reviewed all the available KD studies on PubMed to understand the correlation between the phenotype and genotype of the identified mutation. Results The main manifestations of the proband were sudden onset seizures and cognitive decline. Mutation analysis of the GALC revealed a homozygous c.1901T>C mutation in exon 16, which resulted in an amino acid change in p.L634S. Sanger sequencing results showed that the homozygous mutation was inherited from the patient's parents, both of whom were revealed to be heterozygous carriers. Moreover, a decrease in GALC enzyme activity was also detected. However, no abnormal signals were found in the brain MRI. Further structural MRI analysis revealed a significantly decreased GMV in the proband compared to the normal controls. Moreover, it is of interest that all patients with the c.1901T>C mutation had late‐onset KD and were selected from Asian countries, especially Japan and China. Conclusions This patient with a homozygous GALC mutation expands the clinical presentation and characteristics of adult‐onset KD, as indicated by grey matter atrophy without abnormal white matter signals.

Published
2020
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