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BACKGROUND: Endometriosis is considered as a systemic disease with the presence of proinflammatory cytokines in the circulation, which drives hypercoagulable state of endometriosis. Currently, endometriosis is classified into four stages: I (minimal), II (mild), III (moderate) and IV (severe). The aim of this study is to investigate the correlations between inflammatory markers and coagulation factors in patients diagnosed of endometriosis with stage IV. METHODS: This retrospective case-control study included 171 endometriosis patients with stage IV and 184 controls. Continuous data were expressed by mean ± standard deviation. Mann-Whitney U and χ2 tests were used to compare the medians and frequencies among the groups. Spearman analysis was conducted to determine the correlation among the measured parameters. The diagnostic values of the parameters differentiating endometriomas were tested by receiver operating characteristic (ROC) curve. RESULTS: The time of activated partial thromboplastin time (APTT) was decreased and the concentration of fibrinogen (FIB) and neutrophil-to-lymphocyte ratio (NLR) were increased in women of endometriosis with stage IV. The APTT were negatively correlated with NLR while the concentrations of FIB were positively correlated with NLR. The ROC analysis showed that the Area under the curve (AUC) of FIB was 0.766 (95% confidence interval:0.717-0.814) with sensitivity and specificity reaching 86.5 and 60.9%, respectively. The AUC of CA125 and CA199 was 0.638 (95% confidence interval: 0.578-0.697), 0.71 (95% confidence interval: 0.656-0.763) with sensitivity and specificity reaching 40.9 and 91.8%, 80.7 and 56.5% respectively. The combination of these factors showed the highest AUC of 0.895 (0.862-0.927) with sensitivity of 88.9% and specificity of 77.7%. CONCLUSION: In the present study, we found that inflammatory factors showed significant correlation with APTT or FIB in endometriosis with stage IV. Moreover, the coagulation factors combined with CA125 and CA199 were more reliable for identifying the endometriosis with stage IV.

Objective To investigate the risk factors of the recurrence of stage Ⅰ-Ⅱ endometrial carcinoma. Methods We retrospectively analyzed the data of 516 patients with stage Ⅰ-Ⅱ endometrial carcinoma treated in Nanjing Drum Tower Hospital from January 2010 to December 2017. The recurrence rate of the patients was followed up. Results The recurrence rate was 8.91%(46/516). Age, body weight, hypertension, stage of operation and pathology, pathological type, low expression of ER and PR were correlated with the recurrence of stage Ⅰ-Ⅱ endometrial carcinoma (P < 0.05). Diabetes mellitus, vascular metastasis, pathological differentiation, lymph node excision and ascites cytologic examination were not correlated with the recurrence of stage Ⅰ-Ⅱ endometrial carcinoma (P > 0.05). Age, body weight and blood pressure were independent risk factors for the recurrence of stageⅠ-Ⅱendometrial carcinoma (P < 0.05). Conclusion Age, body weight, hypertension, stage of operation and pathology, pathological type, low expression of ER and PR affect the recurrence of stage Ⅰ-Ⅱ endometrial carcinoma. Advanced age, low body weight and hypertension are independent risk factors for the recurrence of stage Ⅰ-Ⅱ endometrial carcinoma. In clinical work, we should follow up closely stage Ⅰ-Ⅱ endometrial carcinoma patients with advanced age, low body weight and hypertension, for early detection and in-time treatment of recurrence lesions.

Limonite resources is rich, but the utilization rate is very low. In this paper, limonite is used as the raw material for iron correction, and the cement ingredients are controlled by changing the lime saturation coefficient, silicon rate and aluminum rate, in an attempt to prepare a cement, so as to realize the purpose of resource utilization of limonite. Based on a series of laboratory tests on compressive and flexural strength and petrographic analysis, it was concluded that the optimal combination ratio of cement prepared by limonite was: lime saturation coefficient 0.92, silicon ratio 2.55 and aluminum ratio 1.45. The content of limonite was 1.72%, the free calcium oxide of clinker samples was 0.95%, the liquid content was 28.34%, the 3 d flexural strength was 6.0 MPa, the 28 d flexural strength was 8.4 MPa, the 3 d compressive strength was 30.1 MPa, and the 28 d compressive strength was 59.5 MPa. [ABSTRACT FROM AUTHOR]

Influence of molding pressure on Ca(OH)2 carbonation reaction was analyzed by temperature and humidity monitoring, cube compressive strength testing, XRD and SEM test. The conclusions are as follows: calcium hydroxide test block formed under 8 MPa exhibited the most violent carbonation reaction, which is reflected in the high temperature and humidity in the carbonation kettle during the carbonation reaction process. When the molding pressure increases from 10 MPa to 14 MPa, the cube compressive strength and weight gain rate both decreased obviously. For 8 MPa molding pressure, the strongest diffraction peak of calcite exhibited sharper front and smaller half height and width, and the calcite generated by Ca(OH)2 reacting with CO2 presents ellipsoidal shape. [ABSTRACT FROM AUTHOR]