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280 results on '"Zhu, Shizhen"'

18. Genetic predisposition to neuroblastoma results from a regulatory polymorphism that promotes the adrenergic cell state

Author

Weichert-Leahey, Nina, Shi, Hui, Tao, Ting, Oldridge, Derek A., Durbin, Adam D., Abraham, Brian J., Zimmerman, Mark W., Zhu, Shizhen, Wood, Andrew C., Reyon, Deepak, Joung, J. Keith, Young, Richard A., Diskin, Sharon J., Maris, John M., and Look, A. Thomas

Subjects
Adrenergic mechanisms -- Genetic aspects -- Health aspects, Stem cells -- Genetic aspects -- Health aspects, Single nucleotide polymorphisms -- Research, Neuroblastoma -- Genetic aspects -- Risk factors -- Development and progression, Pediatric research, Health care industry
Abstract

Childhood neuroblastomas exhibit plasticity between an undifferentiated neural crest-like mesenchymal cell state and a more differentiated sympathetic adrenergic cell state. These cell states are governed by autoregulatory transcriptional loops called core regulatory circuitries (CRCs), which drive the early development of sympathetic neuronal progenitors from migratory neural crest cells during embryogenesis. The adrenergic cell identity of neuroblastoma requires LMO1 as a transcriptional cofactor. Both LMO1 expression levels and the risk of developing neuroblastoma in children are associated with a single nucleotide polymorphism, G/T, that affects a GATA motif in the first intron of LMO1. Here, we showed that WT zebrafish with the GATA genotype developed adrenergic neuroblastoma, while knock-in of the protective TATA allele at this locus reduced the penetrance of MYCN-driven tumors, which were restricted to the mesenchymal cell state. Whole genome sequencing of childhood neuroblastomas demonstrated that TATA/TATA tumors also exhibited a mesenchymal cell state and were low risk at diagnosis. Thus, conversion of the regulatory GATA to a TATA allele in the first intron of LMO1 reduced the neuroblastoma-initiation rate by preventing formation of the adrenergic cell state. This mechanism was conserved over 400 million years of evolution, separating zebrafish and humans., Introduction Across all cell lineages and tissue types, groups of transcription factors act cooperatively in autoregulatory loops to bind to their own and each other's enhancers to regulate gene expression, [...]

Published
2023
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20. MRI Manifestations of Breast Cancer Stroma and their Role in Predicting Molecular Subtype: A Case-control Study

Author

Wang, Lanyun, primary, Li, Wenjing, additional, Yang, Wenjun, additional, Sun, Xilin, additional, Ding, Yi, additional, Zhao, Qian, additional, Liu, Weiyan, additional, Xie, Xiaoli, additional, Xu, Jingjing, additional, Wei, Ran, additional, Zhu, Shizhen, additional, Ge, Yaqiong, additional, Wu, Pu-Yeh, additional, and Song, Bin, additional

Published
2024
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24. A novel combination therapy targeting ubiquitin-specific protease 5 in MYCN-driven neuroblastoma

Author

Cheung, Belamy B., Kleynhans, Ane, Mittra, Rituparna, Kim, Patrick Y., Holien, Jessica K., Nagy, Zsuzsanna, Ciampa, Olivia C., Seneviratne, Janith A., Mayoh, Chelsea, Raipuria, Mukesh, Gadde, Satyanarayana, Massudi, Hassina, Wong, Iris Poh Ling, Tan, Owen, Gong, Andrew, Suryano, Aldwin, Diakiw, Sonya M., Liu, Bing, Arndt, Greg M., Liu, Tao, Kumar, Naresh, Sangfelt, Olle, Zhu, Shizhen, Norris, Murray D., Haber, Michelle, Carter, Daniel R., Parker, Michael W., and Marshall, Glenn M.

Published
2021
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26. Impact of Aerosols on the Macrophysical and Microphysical Characteristics of Ice-Phase and Mixed-Phase Clouds over the Tibetan Plateau.

Author

Zhu, Shizhen, Qian, Ling, Ma, Xueqian, Qiu, Yujun, Yang, Jing, He, Xin, Li, Junjun, Zhu, Lei, Gong, Jing, and Lu, Chunsong

Subjects
*ICE clouds, *WATER vapor, *PRECIPITABLE water, *AEROSOLS, *ATMOSPHERIC pressure, *HUMIDITY, *SURFACE pressure
Abstract

Using CloudSat/CALIPSO satellite data and ERA5 reanalysis data from 2006 to 2010, the effects of aerosols on ice- and mixed-phase, single-layer, non-precipitating clouds over the Tibetan Plateau during nighttime in the MAM (March to May), JJA (June to August), SON (September to November), and DJF (December to February) seasons were examined. The results indicated the following: (1) The macrophysical and microphysical characteristics of ice- and mixed-phase clouds exhibit a nonlinear trend with increasing aerosol optical depth (AOD). When the logarithm of AOD (lnAOD) was ≤−4.0, with increasing AOD during MAM and JJA nights, the cloud thickness and ice particle effective radius of ice-phase clouds and mixed-phase clouds, the ice water path and ice particle number concentration of ice-phase clouds, and the liquid water path and cloud fraction of mixed-phase clouds all decreased; during SON and DJF nights, the cloud thickness of ice-phase clouds, cloud top height, liquid droplet number concentration, and liquid water path of mixed-phase clouds all decreased. When the lnAOD was >−4.0, with increasing AOD during MAM and JJA nights, the cloud top height, cloud base height, cloud fraction, and ice particle number concentration of ice-phase clouds, and the ice water path of mixed-phase clouds all increased; during SON and DJF nights, the cloud fraction of mixed-phase clouds and the ice water path of ice-phase clouds all increased. (2) Under the condition of excluding meteorological factors, including the U-component of wind, V-component of wind, pressure vertical velocity, temperature, and relative humidity at the atmospheric pressure heights near the average cloud top height, within the cloud, and the average cloud base height, as well as precipitable water vapor, convective available potential energy, and surface pressure. During MAM and JJA nights. When the lnAOD was ≤−4.0, an increase in aerosols may have led to a decrease in the thickness of ice and mixed-phase cloud layers, as well as a reduction in cloud water path values. In contrast, when the lnAOD was >−4.0, an increase in aerosols may contribute to elevated cloud base and cloud top heights for ice-phase clouds. During SON and DJF nights, changes in various cloud characteristics may be influenced by both aerosols and meteorological factors. [ABSTRACT FROM AUTHOR]

Published
2024
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38. Data from MYC Drives a Subset of High-Risk Pediatric Neuroblastomas and Is Activated through Mechanisms Including Enhancer Hijacking and Focal Enhancer Amplification

Author

Zimmerman, Mark W., primary, Liu, Yu, primary, He, Shuning, primary, Durbin, Adam D., primary, Abraham, Brian J., primary, Easton, John, primary, Shao, Ying, primary, Xu, Beisi, primary, Zhu, Shizhen, primary, Zhang, Xiaoling, primary, Li, Zhaodong, primary, Weichert-Leahey, Nina, primary, Young, Richard A., primary, Zhang, Jinghui, primary, and Look, A. Thomas, primary

Published
2023
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39. Supplementary Materials from MYC Drives a Subset of High-Risk Pediatric Neuroblastomas and Is Activated through Mechanisms Including Enhancer Hijacking and Focal Enhancer Amplification

Author

Zimmerman, Mark W., primary, Liu, Yu, primary, He, Shuning, primary, Durbin, Adam D., primary, Abraham, Brian J., primary, Easton, John, primary, Shao, Ying, primary, Xu, Beisi, primary, Zhu, Shizhen, primary, Zhang, Xiaoling, primary, Li, Zhaodong, primary, Weichert-Leahey, Nina, primary, Young, Richard A., primary, Zhang, Jinghui, primary, and Look, A. Thomas, primary

Published
2023
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41. Supplementary Figure S4 A-E from Drugging MYCN Oncogenic Signaling through the MYCN-PA2G4 Binding Interface

Author

Koach, Jessica, primary, Holien, Jessica K., primary, Massudi, Hassina, primary, Carter, Daniel R., primary, Ciampa, Olivia C., primary, Herath, Mika, primary, Lim, Taylor, primary, Seneviratne, Janith A., primary, Milazzo, Giorgio, primary, Murray, Jayne E., primary, McCarroll, Joshua A., primary, Liu, Bing, primary, Mayoh, Chelsea, primary, Keenan, Bryce, primary, Stevenson, Brendan W., primary, Gorman, Michael A., primary, Bell, Jessica L., primary, Doughty, Larissa, primary, Hüttelmaier, Stefan, primary, Oberthuer, Andre, primary, Fischer, Matthias, primary, Gifford, Andrew J., primary, Liu, Tao, primary, Zhang, Xiaoling, primary, Zhu, Shizhen, primary, Gustafson, W. Clay, primary, Haber, Michelle, primary, Norris, Murray D., primary, Fletcher, Jamie I., primary, Perini, Giovanni, primary, Parker, Michael W., primary, Cheung, Belamy B., primary, and Marshall, Glenn M., primary

Published
2023
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42. Figure S3 from Metabolic Enzyme DLST Promotes Tumor Aggression and Reveals a Vulnerability to OXPHOS Inhibition in High-Risk Neuroblastoma

Author

Anderson, Nicole M., primary, Qin, Xiaodan, primary, Finan, Jennifer M., primary, Lam, Andrew, primary, Athoe, Jacob, primary, Missiaen, Rindert, primary, Skuli, Nicolas, primary, Kennedy, Annie, primary, Saini, Amandeep S., primary, Tao, Ting, primary, Zhu, Shizhen, primary, Nissim, Itzhak, primary, Look, A. Thomas, primary, Qing, Guoliang, primary, Simon, M. Celeste, primary, and Feng, Hui, primary

Published
2023
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43. Supplementary Information from Drugging MYCN Oncogenic Signaling through the MYCN-PA2G4 Binding Interface

Author

Koach, Jessica, primary, Holien, Jessica K., primary, Massudi, Hassina, primary, Carter, Daniel R., primary, Ciampa, Olivia C., primary, Herath, Mika, primary, Lim, Taylor, primary, Seneviratne, Janith A., primary, Milazzo, Giorgio, primary, Murray, Jayne E., primary, McCarroll, Joshua A., primary, Liu, Bing, primary, Mayoh, Chelsea, primary, Keenan, Bryce, primary, Stevenson, Brendan W., primary, Gorman, Michael A., primary, Bell, Jessica L., primary, Doughty, Larissa, primary, Hüttelmaier, Stefan, primary, Oberthuer, Andre, primary, Fischer, Matthias, primary, Gifford, Andrew J., primary, Liu, Tao, primary, Zhang, Xiaoling, primary, Zhu, Shizhen, primary, Gustafson, W. Clay, primary, Haber, Michelle, primary, Norris, Murray D., primary, Fletcher, Jamie I., primary, Perini, Giovanni, primary, Parker, Michael W., primary, Cheung, Belamy B., primary, and Marshall, Glenn M., primary

Published
2023
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44. Data from Metabolic Enzyme DLST Promotes Tumor Aggression and Reveals a Vulnerability to OXPHOS Inhibition in High-Risk Neuroblastoma

Author

Anderson, Nicole M., primary, Qin, Xiaodan, primary, Finan, Jennifer M., primary, Lam, Andrew, primary, Athoe, Jacob, primary, Missiaen, Rindert, primary, Skuli, Nicolas, primary, Kennedy, Annie, primary, Saini, Amandeep S., primary, Tao, Ting, primary, Zhu, Shizhen, primary, Nissim, Itzhak, primary, Look, A. Thomas, primary, Qing, Guoliang, primary, Simon, M. Celeste, primary, and Feng, Hui, primary

Published
2023
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45. Supplementary Figure S1 F-I from Drugging MYCN Oncogenic Signaling through the MYCN-PA2G4 Binding Interface

Author

Koach, Jessica, primary, Holien, Jessica K., primary, Massudi, Hassina, primary, Carter, Daniel R., primary, Ciampa, Olivia C., primary, Herath, Mika, primary, Lim, Taylor, primary, Seneviratne, Janith A., primary, Milazzo, Giorgio, primary, Murray, Jayne E., primary, McCarroll, Joshua A., primary, Liu, Bing, primary, Mayoh, Chelsea, primary, Keenan, Bryce, primary, Stevenson, Brendan W., primary, Gorman, Michael A., primary, Bell, Jessica L., primary, Doughty, Larissa, primary, Hüttelmaier, Stefan, primary, Oberthuer, Andre, primary, Fischer, Matthias, primary, Gifford, Andrew J., primary, Liu, Tao, primary, Zhang, Xiaoling, primary, Zhu, Shizhen, primary, Gustafson, W. Clay, primary, Haber, Michelle, primary, Norris, Murray D., primary, Fletcher, Jamie I., primary, Perini, Giovanni, primary, Parker, Michael W., primary, Cheung, Belamy B., primary, and Marshall, Glenn M., primary

Published
2023
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46. Supplementary Figure S5 F-H from Drugging MYCN Oncogenic Signaling through the MYCN-PA2G4 Binding Interface

Author

Koach, Jessica, primary, Holien, Jessica K., primary, Massudi, Hassina, primary, Carter, Daniel R., primary, Ciampa, Olivia C., primary, Herath, Mika, primary, Lim, Taylor, primary, Seneviratne, Janith A., primary, Milazzo, Giorgio, primary, Murray, Jayne E., primary, McCarroll, Joshua A., primary, Liu, Bing, primary, Mayoh, Chelsea, primary, Keenan, Bryce, primary, Stevenson, Brendan W., primary, Gorman, Michael A., primary, Bell, Jessica L., primary, Doughty, Larissa, primary, Hüttelmaier, Stefan, primary, Oberthuer, Andre, primary, Fischer, Matthias, primary, Gifford, Andrew J., primary, Liu, Tao, primary, Zhang, Xiaoling, primary, Zhu, Shizhen, primary, Gustafson, W. Clay, primary, Haber, Michelle, primary, Norris, Murray D., primary, Fletcher, Jamie I., primary, Perini, Giovanni, primary, Parker, Michael W., primary, Cheung, Belamy B., primary, and Marshall, Glenn M., primary

Published
2023
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47. Supplementary Figure S3 F-G from Drugging MYCN Oncogenic Signaling through the MYCN-PA2G4 Binding Interface

Author

Koach, Jessica, primary, Holien, Jessica K., primary, Massudi, Hassina, primary, Carter, Daniel R., primary, Ciampa, Olivia C., primary, Herath, Mika, primary, Lim, Taylor, primary, Seneviratne, Janith A., primary, Milazzo, Giorgio, primary, Murray, Jayne E., primary, McCarroll, Joshua A., primary, Liu, Bing, primary, Mayoh, Chelsea, primary, Keenan, Bryce, primary, Stevenson, Brendan W., primary, Gorman, Michael A., primary, Bell, Jessica L., primary, Doughty, Larissa, primary, Hüttelmaier, Stefan, primary, Oberthuer, Andre, primary, Fischer, Matthias, primary, Gifford, Andrew J., primary, Liu, Tao, primary, Zhang, Xiaoling, primary, Zhu, Shizhen, primary, Gustafson, W. Clay, primary, Haber, Michelle, primary, Norris, Murray D., primary, Fletcher, Jamie I., primary, Perini, Giovanni, primary, Parker, Michael W., primary, Cheung, Belamy B., primary, and Marshall, Glenn M., primary

Published
2023
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48. Supplementary Figure S6 A-F from Drugging MYCN Oncogenic Signaling through the MYCN-PA2G4 Binding Interface

Author

Koach, Jessica, primary, Holien, Jessica K., primary, Massudi, Hassina, primary, Carter, Daniel R., primary, Ciampa, Olivia C., primary, Herath, Mika, primary, Lim, Taylor, primary, Seneviratne, Janith A., primary, Milazzo, Giorgio, primary, Murray, Jayne E., primary, McCarroll, Joshua A., primary, Liu, Bing, primary, Mayoh, Chelsea, primary, Keenan, Bryce, primary, Stevenson, Brendan W., primary, Gorman, Michael A., primary, Bell, Jessica L., primary, Doughty, Larissa, primary, Hüttelmaier, Stefan, primary, Oberthuer, Andre, primary, Fischer, Matthias, primary, Gifford, Andrew J., primary, Liu, Tao, primary, Zhang, Xiaoling, primary, Zhu, Shizhen, primary, Gustafson, W. Clay, primary, Haber, Michelle, primary, Norris, Murray D., primary, Fletcher, Jamie I., primary, Perini, Giovanni, primary, Parker, Michael W., primary, Cheung, Belamy B., primary, and Marshall, Glenn M., primary

Published
2023
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49. Supplementary Figure S2A-C from Drugging MYCN Oncogenic Signaling through the MYCN-PA2G4 Binding Interface

Author

Koach, Jessica, primary, Holien, Jessica K., primary, Massudi, Hassina, primary, Carter, Daniel R., primary, Ciampa, Olivia C., primary, Herath, Mika, primary, Lim, Taylor, primary, Seneviratne, Janith A., primary, Milazzo, Giorgio, primary, Murray, Jayne E., primary, McCarroll, Joshua A., primary, Liu, Bing, primary, Mayoh, Chelsea, primary, Keenan, Bryce, primary, Stevenson, Brendan W., primary, Gorman, Michael A., primary, Bell, Jessica L., primary, Doughty, Larissa, primary, Hüttelmaier, Stefan, primary, Oberthuer, Andre, primary, Fischer, Matthias, primary, Gifford, Andrew J., primary, Liu, Tao, primary, Zhang, Xiaoling, primary, Zhu, Shizhen, primary, Gustafson, W. Clay, primary, Haber, Michelle, primary, Norris, Murray D., primary, Fletcher, Jamie I., primary, Perini, Giovanni, primary, Parker, Michael W., primary, Cheung, Belamy B., primary, and Marshall, Glenn M., primary

Published
2023
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50. Supplementary Figure S6 G-K from Drugging MYCN Oncogenic Signaling through the MYCN-PA2G4 Binding Interface

Author

Koach, Jessica, primary, Holien, Jessica K., primary, Massudi, Hassina, primary, Carter, Daniel R., primary, Ciampa, Olivia C., primary, Herath, Mika, primary, Lim, Taylor, primary, Seneviratne, Janith A., primary, Milazzo, Giorgio, primary, Murray, Jayne E., primary, McCarroll, Joshua A., primary, Liu, Bing, primary, Mayoh, Chelsea, primary, Keenan, Bryce, primary, Stevenson, Brendan W., primary, Gorman, Michael A., primary, Bell, Jessica L., primary, Doughty, Larissa, primary, Hüttelmaier, Stefan, primary, Oberthuer, Andre, primary, Fischer, Matthias, primary, Gifford, Andrew J., primary, Liu, Tao, primary, Zhang, Xiaoling, primary, Zhu, Shizhen, primary, Gustafson, W. Clay, primary, Haber, Michelle, primary, Norris, Murray D., primary, Fletcher, Jamie I., primary, Perini, Giovanni, primary, Parker, Michael W., primary, Cheung, Belamy B., primary, and Marshall, Glenn M., primary

Published
2023
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