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Esophageal cancer is a major global health challenge with a poor prognosis. Recent studies underscore the extracellular matrix (ECM) role in cancer progression, but the full impact of ECM‐related genes on patient outcomes remains unclear. Our study utilized next‐generation sequencing and clinical data from esophageal cancer patients provided by The Cancer Genome Atlas, employing the R package in RStudio for computational analysis. This analysis identified significant associations between patient survival and various ECM‐related genes, including IBSP, LINGO4, COL26A1, MMP12, KLK4, RTBDN, TENM1, GDF15, and RUNX1. Consequently, we developed a prognostic model to predict patient outcomes, which demonstrated clear survival differences between high‐risk and low‐risk patient groups. Our comprehensive review encompassed clinical correlations, biological pathways, and variations in immune response among these risk categories. We also constructed a nomogram integrating clinical information with risk assessment. Focusing on the TENM1 gene, we found it significantly impacts immune response, showing a positive correlation with T helper cells, NK cells, and CD8+ T cells, but a negative correlation with neutrophils and Th17 cells. Gene Set Enrichment Analysis revealed enhanced pathways related to pancreatic beta cells, spermatogenesis, apical junctions, and muscle formation in patients with high TENM1 expression. This research provides new insights into the role of ECM genes in esophageal cancer and informs future research directions. [ABSTRACT FROM AUTHOR]

Background: Prior prelabor cesarean delivery (CD) was associated with an increase in the risk of placenta previa (PP) in a second delivery, whether it may impact postpartum hemorrhage (PPH) independent of abnormal placentation. This study aimed to assess the risk of PPH stratified by abnormal placentation following a first CD before the onset of labor (prelabor) or intrapartum CD.Methods: This multicenter, historical cohort study involved singleton, pregnant women at 28 weeks of gestation or greater with a CD history between January 2017 and December 2017 in 11 public tertiary hospitals within 7 provinces of China. PPH was analyzed in the subsequent pregnancy between women with prior prelabor CD and women with intrapartum CD. Furthermore, PPH was analyzed in pregnant women stratified by complications with PP alone [without placenta accreta spectrum (PAS) disorders], complications with PP and PAS, complications with PAS alone (without PP), and normal placentation. We performed multivariate logistic regression to calculate adjusted odds ratios (aOR) and 95% CI controlling for predefined covariates.Results: Out of 10,833 pregnant women, 1,197 (11%) women had a history of intrapartum CD and 9,636 (89%) women had a history of prelabor CD. Prior prelabor CD increased the risk of PP (aOR 1.91, 95% CI 1.40–2.60), PAS (aOR 1.68, 95% CI 1.11–2.24), and PPH (aOR 1.33, 95% CI 1.02–1.75) in a subsequent pregnancy. After stratification by complications with PP alone, PP and PAS, PAS alone, and normal placentation, prior prelabor CD only increased the risk of PPH (aOR 3.34, 95% CI 1.35–8.23) in a subsequent pregnancy complicated with PP and PAS.Conclusion: Compared to intrapartum CD, prior prelabor CD increased the risk of PPH in a subsequent pregnancy only when complicated by PP and PAS.

Background: In order to gain a deeper understanding of the relationship between physical activity and adolescent mental health in the post COVID-19 pandemic era, self-esteem and social anxiety were used as mediating variables to explore the potential mechanisms by which physical activity affects adolescent mental health. Methods: The study used the HELP-II Health Promoting Lifestyle Scale, the SPIN Social Phobia Scale, the Self-Esteem Scale, and the 10-item Kessler Psychological Distress Scale to administer questionnaires to 400 Chinese secondary school students, and SPSS 26.0 and PROCESS 3.3 were used to process the data. Results: The findings showed that (1) physical activity was significantly and positively associated with mental health; (2) self-esteem and social anxiety played a fully mediating role between physical activity and adolescent mental health respectively; (3) self-esteem and social anxiety played a chain mediating role between physical activity and adolescent mental health. Conclusion: This study reveals the relationship and influencing mechanism between physical activity and adolescent mental health in the post COVID-19 pandemic era. Appropriate interventions for physical activity, self-esteem, and social anxiety may be beneficial to adolescent mental health. The protective role of self-esteem in adolescent mental health should be the focus of future studies, and further investigations into the association between the COVID-19 and adolescent mental health are warranted. [ABSTRACT FROM AUTHOR]

Cow milk is an important source of protein, but it is also a food that can cause allergies. In this research, a novel photoelectrochemical immunosensor based on CdWO4–CdS type-II heterojunction was constructed for the detection of allergen α -lactalbumin (α -Lac) in milk. CdWO4–CdS heterojunction was synthesized by one-step hydrothermal method. Compared with pure CdWO4, the CdWO4–CdS heterojunction significantly improved the photocurrent intensity. The polydopamine (PDA) was used as a crosslinking agent to couple basis materials and biomolecules. Ascorbic acid was used as an efficient electron donor to eliminate the photo-generated holes and inhibit the recombination of photo-generated electrons and holes. Under the optimum experimental conditions, the photocurrent intensity reduced linearly with the logarithm of α -Lac concentration ranging from 0.001 ng ⋅ mL − 1 to 10 ng ⋅ mL − 1 and the limit of detection was 0.17 pg ⋅ mL − 1 . The constructed photoelectrochemical immunosensor exhibited excellent stability, selectivity and reproducibility, which provided a novel ideal for sensitive detection of α -Lac and shed light on monitoring of other allergenic proteins in foods. In this research, the CdWO4–CdS heterojunction was synthesized by a one-step hydrothermal method. Under CdS sensitization, CdWO4–CdS exhibited excellent visible light performance. On this basis, using polydopamine as a cross-linking agent to couple the substrate material and biomolecules, a new type of photoelectrochemical immunosensor was constructed, which provided a new method for the detection of α-lactalbumin. [ABSTRACT FROM AUTHOR]

The study tries to explore the development characteristics and function efficiency of sport NEEQ market. It is believed that the sport NEEQ market is the core sport capital market which plays the fundamental and dominant role in supporting sport industry in China, and it is faced with the problems of potential space restriction of scale and quality, financing and transaction efficiency, institutional support, etc. The study holds that sport NEEQ market in China will gain continuous development and play important roles in introducing social capital, fostering subjects of sport industry, consolidating the development foundation of sport industry and so on, by means of the better implementation of the capital market efficiency of the related micro subjects, through the realization of market value, the improvement of allocation conditions, and the support of innovation development, etc. [ABSTRACT FROM AUTHOR]

Background: Pregnancy-related anemia presents a significant health concern for approximately 500 million women of reproductive age worldwide. To better prevent maternal disorders, it is essential to understand the impact of iron deficiency across different maternal disorders, regions, age groups, and subcategories., Methods: Based on the comprehensive maternal disorders data sourced from the 2019 Global Burden of Disease study, an investigation was carried out focusing on Disability-Adjusted Life Years (DALYs) associated with iron deficiency spanning the period from 1990 to 2019. In addition, Estimated Annual Percentage Changes (EAPCs) were computed for the duration of the study., Results: Our study indicates decreasing mortality rates and years of life lost due to maternal conditions related to iron deficiency, such as maternal hemorrhage, miscarriage, abortion, hypertensive disorders, and infections. However, mortality rates and years of life lost due to indirect and late maternal deaths, as well as deaths aggravated by HIV/AIDS, have increased in high socio-demographic index (SDI) regions, especially in North America. Moreover, the proportion of maternal deaths aggravated by HIV/AIDS due to iron deficiency is rising globally, especially in Southern Sub-Saharan Africa, Oceania, and Georgia. In addition, in the Maldives, the age-standardized DALYs for maternal disorders attributable to iron deficiency exhibited a notable decreasing trend, encompassing a range of conditions. Furthermore, there was a significant decrease in Disability-Adjusted Life Years rate for miscarriages and preterm births among women aged 15-49, with hypertensive disorders posing the highest burden among women aged 15-39., Conclusion: The burden of maternal disorders caused by iron deficiency is decreasing in most regions and subtypes, except for deaths aggravated by HIV/AIDS. By thoroughly understanding the details of how iron deficiency impacts the health of pregnant women, health policymakers, healthcare professionals, and researchers can more effectively pinpoint and address the root causes of inequalities in maternal health., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2024 Wu, Ye, Ba, Caikai, Ba, Li and Zhu.)

Food allergies have become a nonnegligible food safety issue, and milk allergies are one of the most common food allergies, that has attracted large consumer attention. In this work, a novel label-free photoelectrochemical (PEC) immunosensor for the detection of the allergen β-lactoglobulin (β-LG) in dairy products was designed that used the specific recognition of allergen β-LG and antibodies in dairy products in combination with biosensing technology. Here, Ag 2 S-sensitized spindle-shaped BiVO 4 /BiOBr heterojunction was fixed on the surface of the ITO electrode as an excellent photoactive substrate and effectively improved the photocurrent responses and sensitivity. Thioglycolic acid (TGA) was used as a linker to immobilize the β-LG antibody on the surface of the electrode. The photocurrent was detected at different antigen concentrations, which realized the quantitative testing of β-LG. Under the optimal experimental conditions, the PEC immunosensor proved an ideal linear relationship ranging from 10 pg/mL to 100 ng/mL, with a low detection limit of 3.7 pg/mL. The designed immunosensor showed good stability, a wide linear range, high sensitivity and good reproducibility and could be used for the detection of actual samples. The PEC immunosensor had a strong ability to specifically recognize β-LG, which was not affected by other proteins in the milk without pretreatment. Meanwhile, the developed immunosensor provided a promising PEC detection platform and reference idea for the detection of other proteins in milk., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2020 Elsevier B.V. All rights reserved.)