Search

Your search keyword '"Zhu, Lingyan"' showing total 1,527 results
Start Over Author "Zhu, Lingyan"
1,527 results on '"Zhu, Lingyan"'

3. Efficacy and safety of novel multifunctional M10 CAR-T cells in HIV-1-infected patients: a phase I, multicenter, single-arm, open-label study

Author

Mao, Yunyu, Liao, Qibin, Zhu, Youwei, Bi, Mingyuan, Zou, Jun, Zheng, Nairong, Zhu, Lingyan, Zhao, Chen, Liu, Qing, Liu, Li, Chen, Jun, Gu, Ling, Liu, Zhuoqun, Pan, Xinghao, Xue, Ying, Feng, Meiqi, Ying, Tianlei, Zhou, Pingyu, Wu, Zhanshuai, Xiao, Jian, Zhang, Renfang, Leng, Jing, Sun, Yongtao, Zhang, Xiaoyan, and Xu, Jianqing

Published
2024
Full Text
View/download PDF

30. Exploring Route-Specific Pharmacokinetics of PFAS in Mice by Coupling in Vivo Tests and Physiologically Based Toxicokinetic Models

Author

Zhu, Yumin, Pan, Xiaoyu, Jia, Yibo, Yang, Xin, Song, Xiaohua, Ding, Jiaqi, Zhong, Wenjue, Feng, Jianfeng, and Zhu, Lingyan

Subjects
Ammonium perfluorooctanoate, Surface active agents, Skin, Environmental issues, Health
Abstract

Background: Oral ingestion, inhalation, and skin contact are important exposure routes for humans to uptake per- and polyfluoroalkyl substances (PFAS). However, nasal and dermal exposure to PFAS remains unclear, and accurately predicting internal body burden of PFAS in humans via multiple exposure pathways is urgently required. Objectives: We aimed to develop multiple physiologically based toxicokinetic (PBTK) models to unveil the route- specific pharmacokinetics and bioavailability of PFAS via respective oral, nasal, and dermal exposure pathways using a mouse model and sought to predict the internal concentrations in various tissues through multiple exposure routes and extrapolate it to humans. Methods: Mice were administered the mixed solution of perfluorohexane sulfonate, perfluorooctane sulfonate, and perfluorooctanoic acid through oral, nasal, and dermal exposure separately or jointly. The time-dependent concentrations of PFAS in plasma and tissues were determined to calibrate and validate the individual and combined PBTK models, which were applied in single- and repeated-dose scenarios. Results: The developed route-specific PBTK models successfully simulated the tissue concentrations of PFAS in mice following single or joint exposure routes as well as long-term repeated dose scenarios. The time to peak concentration of PFAS in plasma via dermal exposure was much longer (34.1-83.0 h) than that via nasal exposure (0.960 h). The bioavailability of PFAS via oral exposure was the highest (73.2%-98.0%), followed by nasal (33.9%-66.8%) and dermal exposure (4.59%-7.80%). This model was extrapolated to predict internal levels in human under real environment. Discussion: Based on these data, we predict the following: PFAS were absorbed quickly via nasal exposure, whereas a distinct hysteresis effect was observed for dermal exposure. Almost all the PFAS to which mice were exposed via gastrointestinal route were absorbed into plasma, which exhibited the highest bioavailability. Exhalation clearance greatly depressed the bioavailability of PFAS via nasal exposure, whereas the lowest bioavailability in dermal exposure was because of the interception of PFAS within the skin layers. https://doi.org/10.1289/EHP11969, Introduction Since the 1950s, per- and polyfluoroalkyl substances (PFAS) have been widely used in a variety of industrial and household fields owing to their excellent surface activity, thermal and chemical [...]

Published
2023
Full Text
View/download PDF

37. Bridging photochemistry and photomechanics with NMR crystallography: the molecular basis for the macroscopic expansion of an anthracene ester nanorod

Author

Chalek, Kevin R, Dong, Xinning, Tong, Fei, Kudla, Ryan A, Zhu, Lingyan, Gill, Adam D, Xu, Wenwen, Yang, Chen, Hartman, Joshua D, Magalhães, Alviclér, Al-Kaysi, Rabih O, Hayward, Ryan C, Hooley, Richard J, Beran, Gregory JO, Bardeen, Christopher J, and Mueller, Leonard J

Subjects
Macromolecular and Materials Chemistry, Chemical Sciences, Bioengineering, Chemical sciences
Abstract

Crystals composed of photoreactive molecules represent a new class of photomechanical materials with the potential to generate large forces on fast timescales. An example is the photodimerization of 9-tert-butyl-anthracene ester (9TBAE) in molecular crystal nanorods that leads to an average elongation of 8%. Previous work showed that this expansion results from the formation of a metastable crystalline product. In this article, it is shown how a novel combination of ensemble oriented-crystal solid-state NMR, X-ray diffraction, and first principles computational modeling can be used to establish the absolute unit cell orientations relative to the shape change, revealing the atomic-resolution mechanism for the photomechanical response and enabling the construction of a model that predicts an elongation of 7.4%, in good agreement with the experimental value. According to this model, the nanorod expansion does not result from an overall change in the volume of the unit cell, but rather from an anisotropic rearrangement of the molecular contents. The ability to understand quantitatively how molecular-level photochemistry generates mechanical displacements allows us to predict that the expansion could be tuned from +9% to -9.5% by controlling the initial orientation of the unit cell with respect to the nanorod axis. This application of NMR-assisted crystallography provides a new tool capable of tying the atomic-level structural rearrangement of the reacting molecular species to the mechanical response of a nanostructured sample.

Published
2021

44. Bridging photochemistry and photomechanics with NMR crystallography: the molecular basis for the macroscopic expansion of an anthracene ester nanorod.

Author

Chalek, Kevin R, Dong, Xinning, Tong, Fei, Kudla, Ryan A, Zhu, Lingyan, Gill, Adam D, Xu, Wenwen, Yang, Chen, Hartman, Joshua D, Magalhães, Alviclér, Al-Kaysi, Rabih O, Hayward, Ryan C, Hooley, Richard J, Beran, Gregory JO, Bardeen, Christopher J, and Mueller, Leonard J

Subjects
Chemical Sciences
Abstract

Crystals composed of photoreactive molecules represent a new class of photomechanical materials with the potential to generate large forces on fast timescales. An example is the photodimerization of 9-tert-butyl-anthracene ester (9TBAE) in molecular crystal nanorods that leads to an average elongation of 8%. Previous work showed that this expansion results from the formation of a metastable crystalline product. In this article, it is shown how a novel combination of ensemble oriented-crystal solid-state NMR, X-ray diffraction, and first principles computational modeling can be used to establish the absolute unit cell orientations relative to the shape change, revealing the atomic-resolution mechanism for the photomechanical response and enabling the construction of a model that predicts an elongation of 7.4%, in good agreement with the experimental value. According to this model, the nanorod expansion does not result from an overall change in the volume of the unit cell, but rather from an anisotropic rearrangement of the molecular contents. The ability to understand quantitatively how molecular-level photochemistry generates mechanical displacements allows us to predict that the expansion could be tuned from +9% to -9.5% by controlling the initial orientation of the unit cell with respect to the nanorod axis. This application of NMR-assisted crystallography provides a new tool capable of tying the atomic-level structural rearrangement of the reacting molecular species to the mechanical response of a nanostructured sample.

Published
2020

Catalog

Books, media, physical & digital resources
See catalog results