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Postoperative barium meal angiography and gastroscopy showed that the esophagus had no stenosis (Figure 3B,D). A contrast-enhanced chest computed tomography (CT) scan showed a homogeneous esophageal soft tissue mass located from the seventh cervical vertebra to the sixth thoracic vertebra with a maximal cross-sectional area of 5.5 cm × 4.8 cm and no calcification (Figure 1A,B). With a range of 11.4 cm × 4.6 cm, barium meal angiography showed deviation of the upper-middle part of the esophagus to the right side, and the esophageal lining was soft without breakage (Figure 3A). Keywords: esophagus; follicular lymphoma; gastrointestinal lymphoma EN esophagus follicular lymphoma gastrointestinal lymphoma 660 663 4 02/28/23 20221101 NES 221101 Gastrointestinal (GI) lymphoma accounts for 30%-50% of all primary extranodal lymphomas, the majority of which are non-Hodgkin's lymphomas (NHL) with B-cell type predominance.[[1]] The stomach and small intestine are the most commonly affected sites of GI lymphomas,[1] whereas esophagus was affected in less than 1% of the cases.[[3]] Histologically, 70%-80% of extranodal marginal zone lymphomas are mucosa-associated lymphoid tissue (MALT) lymphoma and diffuse large B-cell lymphoma (DLBCL).[[2], [5]] Approximately 9% of primary GI lymphomas are follicular lymphomas,[5] typically involving the duodenum and terminal ileum.[[6]] Primary esophageal follicular lymphoma is extremely rare, accounting for less than 4% of all primary esophageal NHLs. SP 2 sp Here we presented a rare case of a giant primary esophageal follicular lymphoma which was surgically resected I en bloc i . [Extracted from the article]