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Children’s fear and anxiety and dental behavioral management problems are relatively usual in dental settings, and it is a barrier to dental care. Many factors associated with these problems will be reviewed from the aspects of doctor, patient and guardian, in order to reduce the incidence of dental fear and anxiety/dental behavioral management problem in dental departments.

Next-generation sequencing studies had reported that a rare coding variant p.V232M in PLD3 was associated with Alzheimer's disease (AD) and a two-fold increased AD risk in European cohorts. To test whether coding region variants of PLD3 were associated with AD in a large Han Chinese cohort, we performed sequencing to analyze all exons of PLD3, and demonstrated that rare variants p.I163M and c.1020-8G>A conferred considerable risk of late-onset AD (LOAD) in our cohort. Meanwhile, the previously reported p.V232M variant was identified in our AD group. These findings indicate that rare variants of PLD3 may play an important role in LOAD in northern Han Chinese. [ABSTRACT FROM AUTHOR]

Objective: To analyze the common dental agenesis patterns of the oligodontia patients., Methods: The information of 64 oligodontia patients was collected, including the histories, oral examinations and panoramic radiographs. The Tooth Agenesis Code (TAC) procedure was used to analyze the agenesis pattern of each quadrant., Results: In the maxilla, 63% (40/64) (right side) and 58% (37/64) (left side) could be described using eight different patterns. The most common pattern was agenesis of the maxillary lateral incisor, canine and both premolars.In the mandible, 52% (33/64) (right side) and 53% (34/64) (left side) of the patients could be described using only five different patterns, the most common pattern was agenesis of both mandibular premolars., Conclusions: Common patterns of tooth agenesis were successfully identified in non-syndromic oligodontia patients.

Objective: To compare and analyse the distribution and characteristic of born missing teeth., Methods: A total of 183 simple hypodontia patients was reviewed and statistically analysed., Results: There was no significant difference in the number of missing teeth between different sexs (P > 0.05), and there was also no significant difference in the number of missing teeth among different sites (maxilla, mandible or left and right sides) (P > 0.05). The mandibular second premolar was the most frequently missing tooth. The missing molars were more commonly seen in oligodontia patients who had six missing teeth or beyond than hypodontia patients with less than six missing teeth (P < 0.05)., Conclusions: Each hypodontia patient has his own clinical manifestation, and appropriate treatment should be planed accordingly for these patients.

Objective: To evaluate the clinical results of three bonding patterns for the reattachment of anterior fractured teeth., Methods: The reattachment of 59 anterior fractured teeth was performed using three bonding patterns, which were pattern A (pulp chamber concave + labial chamfer), pattern B (pulp chamber concave + lingual notch) and pattern C (pulp chamber concave + lingual notch + labial chamfer), and followed up for more than 24 months. Pattern A, B and C were 14 teeth, 14 teeth and 31 teeth, respectively. Twenty-one sectioned maxillary central incisors (obtained from patients with periodontal disease) whose edge fragments reattached using the three bonding patterns were used for the experimental study of shear bond strength, and each pattern was used in 7 teeth., Results: Three reattached teeth fractured again due to another trauma, two of which was pattern B and one was pattern A. The reattachment of the remaining 56 anterior fractured teeth was successful after a follow up of mean 28.3 months. The experimental study showed that bonding pattern A and C could bear more shear stress than bonding pattern B (F = 5.161, P = 0.017)., Conclusions: The present study suggests that bonding pattern A (pulp chamber concave + labial chamfer) and C (pulp chamber concave + lingual notch + labial chamfer) were the best methods for the reattachment of fractured anterior teeth.