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1,711 results on '"Zhu, Hongtao"'

4. Integrating Active Learning in Causal Inference with Interference: A Novel Approach in Online Experiments

Author

Zhu, Hongtao, Zhang, Sizhe, Su, Yang, Zhao, Zhenyu, and Chen, Nan

Subjects
Statistics - Methodology, Computer Science - Machine Learning, Statistics - Machine Learning
Abstract

In the domain of causal inference research, the prevalent potential outcomes framework, notably the Rubin Causal Model (RCM), often overlooks individual interference and assumes independent treatment effects. This assumption, however, is frequently misaligned with the intricate realities of real-world scenarios, where interference is not merely a possibility but a common occurrence. Our research endeavors to address this discrepancy by focusing on the estimation of direct and spillover treatment effects under two assumptions: (1) network-based interference, where treatments on neighbors within connected networks affect one's outcomes, and (2) non-random treatment assignments influenced by confounders. To improve the efficiency of estimating potentially complex effects functions, we introduce an novel active learning approach: Active Learning in Causal Inference with Interference (ACI). This approach uses Gaussian process to flexibly model the direct and spillover treatment effects as a function of a continuous measure of neighbors' treatment assignment. The ACI framework sequentially identifies the experimental settings that demand further data. It further optimizes the treatment assignments under the network interference structure using genetic algorithms to achieve efficient learning outcome. By applying our method to simulation data and a Tencent game dataset, we demonstrate its feasibility in achieving accurate effects estimations with reduced data requirements. This ACI approach marks a significant advancement in the realm of data efficiency for causal inference, offering a robust and efficient alternative to traditional methodologies, particularly in scenarios characterized by complex interference patterns., Comment: conference paper

Published
2024

6. Structural basis for the allosteric regulation and dynamic assembly of DNMT3B.

Author

Lu, Jiuwei, Fang, Jian, Zhu, Hongtao, Liang, Kimberly, Khudaverdyan, Nelli, and Song, Jikui

Abstract

Oligomerization of DNMT3B, a mammalian de novo DNA methyltransferase, critically regulates its chromatin targeting and DNA methylation activities. However, how the N-terminal PWWP and ADD domains interplay with the C-terminal methyltransferase (MTase) domain in regulating the dynamic assembly of DNMT3B remains unclear. Here, we report the cryo-EM structure of DNMT3B under various oligomerization states. The ADD domain of DNMT3B interacts with the MTase domain to form an autoinhibitory conformation, resembling the previously observed DNMT3A autoinhibition. Our combined structural and biochemical study further identifies a role for the PWWP domain and its associated ICF mutation in the allosteric regulation of DNMT3B tetramer, and a differential functional impact on DNMT3B by potential ADD-H3K4me0 and PWWP-H3K36me3 bindings. In addition, our comparative structural analysis reveals a coupling between DNMT3B oligomerization and folding of its substrate-binding sites. Together, this study provides mechanistic insights into the allosteric regulation and dynamic assembly of DNMT3B.

Published
2023

15. Research on Fault Diagnosis and Related Control Software of Armored Vehicle Magnetorheological Suspension System

Author

Liang, Jiahao, Zhu, Hongtao, Zhu, Wei, Chaari, Fakher, Series Editor, Gherardini, Francesco, Series Editor, Ivanov, Vitalii, Series Editor, Haddar, Mohamed, Series Editor, Cavas-Martínez, Francisco, Editorial Board Member, di Mare, Francesca, Editorial Board Member, Kwon, Young W., Editorial Board Member, Trojanowska, Justyna, Editorial Board Member, Xu, Jinyang, Editorial Board Member, Rui, Xiaoting, editor, and Liu, Caishan, editor

Published
2024
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16. Temperature-Dependent Normalized Bouc-Wen Model for MR Damper

Author

Zhu, Hongtao, Rui, Xiaoting, Chaari, Fakher, Series Editor, Gherardini, Francesco, Series Editor, Ivanov, Vitalii, Series Editor, Haddar, Mohamed, Series Editor, Cavas-Martínez, Francisco, Editorial Board Member, di Mare, Francesca, Editorial Board Member, Kwon, Young W., Editorial Board Member, Trojanowska, Justyna, Editorial Board Member, Xu, Jinyang, Editorial Board Member, Rui, Xiaoting, editor, and Liu, Caishan, editor

Published
2024
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17. Vibration Reduction of Tracked Vehicle-Seat-Occupant System Based on Two-Stage Magnetorheological Suspension

Author

Jiang, Rilang, Rui, Xiaoting, Zhu, Wei, Wei, Min, Zhu, Hongtao, Gu, Lilin, Chaari, Fakher, Series Editor, Gherardini, Francesco, Series Editor, Ivanov, Vitalii, Series Editor, Haddar, Mohamed, Series Editor, Cavas-Martínez, Francisco, Editorial Board Member, di Mare, Francesca, Editorial Board Member, Kwon, Young W., Editorial Board Member, Trojanowska, Justyna, Editorial Board Member, Xu, Jinyang, Editorial Board Member, Rui, Xiaoting, editor, and Liu, Caishan, editor

Published
2024
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