1. Expression and significance of miR-21 in multiple myeloma patients
- Author
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Yang Zd, Liu Fr, Man Dl, Jin‑Hang Wang, Hong Shang, Zhou Ww, and Bo‑Xin Liu
- Subjects
0301 basic medicine ,Adult ,Male ,Immunoglobulins ,Monoclonal Gammopathy of Undetermined Significance ,03 medical and health sciences ,0302 clinical medicine ,Gene expression ,Genetics ,medicine ,Biomarkers, Tumor ,Humans ,Clinical significance ,Molecular Biology ,Multiple myeloma ,Aged ,Aged, 80 and over ,business.industry ,General Medicine ,Middle Aged ,medicine.disease ,Molecular biology ,Up-Regulation ,Gene Expression Regulation, Neoplastic ,MicroRNAs ,030104 developmental biology ,Real-time polymerase chain reaction ,030220 oncology & carcinogenesis ,Immunology ,Female ,business ,Multiple Myeloma ,Monoclonal gammopathy of undetermined significance - Abstract
The aim of the present study is to examine the expression level of peripheral mir-21 in multiple myeloma (MM) patients and to determine its clinical significance. MM patients (30), monoclonal gammopathy of undetermined significance (MGUS) patients (14), and normal controls (20) were recruited to determine the serum level of β2-MG, IgA and IgM, IgG, λ, κ, TP, ALB, Hb, LDH, and Ca2+. Gene expression of mir-21 was quantified by SYBR green real-time fluorescent quantitative PCR. We found that the expression level of serum mir-21 in the MM group was significantly higher than the MGUS group and the NC group (P The aim of the present study is to examine the expression level of peripheral mir-21 in multiple myeloma (MM) patients and to determine its clinical significance. MM patients (30), monoclonal gammopathy of undetermined significance (MGUS) patients (14), and normal controls (20) were recruited to determine the serum level of β2-MG, IgA and IgM, IgG, λ, κ, TP, ALB, Hb, LDH, and Ca2+. Gene expression of mir-21 was quantified by SYBR green real-time fluorescent quantitative PCR. We found that the expression level of serum mir-21 in the MM group was significantly higher than the MGUS group and the NC group (P
- Published
- 2016