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Abstract The hypoxia-inducible factor-1α (HIF-1α) pathway coordinates skeletal bone homeostasis and endocrine functions. Activation of the HIF-1α pathway increases glucose uptake by osteoblasts, which reduces blood glucose levels. However, it is unclear whether activating the HIF-1α pathway in osteoblasts can help normalize glucose metabolism under diabetic conditions through its endocrine function. In addition to increasing bone mass and reducing blood glucose levels, activating the HIF-1α pathway by specifically knocking out Von Hippel‒Lindau (Vhl) in osteoblasts partially alleviated the symptoms of streptozotocin (STZ)-induced type 1 diabetes mellitus (T1DM), including increased glucose clearance in the diabetic state, protection of pancreatic β cell from STZ-induced apoptosis, promotion of pancreatic β cell proliferation, and stimulation of insulin secretion. Further screening of bone-derived factors revealed that islet regeneration-derived protein III gamma (RegIIIγ) is an osteoblast-derived hypoxia-sensing factor critical for protection against STZ-induced T1DM. In addition, we found that iminodiacetic acid deferoxamine (SF-DFO), a compound that mimics hypoxia and targets bone tissue, can alleviate symptoms of STZ-induced T1DM by activating the HIF-1α-RegIIIγ pathway in the skeleton. These data suggest that the osteoblastic HIF-1α-RegIIIγ pathway is a potential target for treating T1DM.

ObjectivesThe existing hybrid energy storage system control strategy finds it difficult to maintain the state of charge (SOC) within a reasonable range while also meeting the advanced charging and discharging needs due to future wind power fluctuations. Therefore, a new advanced fuzzy control strategy for hybrid energy storage systems was proposed, which takes into account the smoothing of future wind power fluctuations.MethodsFirstly, the wind power needing to be smoothed by different types of energy storage devices was decomposed using the ensemble empirical mode decomposition (EEMD) method. Secondly, the power correction parameter was adjusted according to the SOC and power saturation level of the hybrid energy storage system to correct its output power. Thirdly, the wind power prediction algorithm was used to obtain the predicted value of wind power in the forward-looking cycle. The advance charging and discharging parameters were adjusted to correct the output power of the energy storage system based on the wind power fluctuations in the forward-looking cycle and the over-advance control theory. Finally, taking the actual data of a wind farm as an example, the validity of the proposed forward-looking fuzzy control strategy was validated through simulation.ResultsThe proposed control strategy can not only reduce the over-limit probability of wind power grid-connected fluctuation, significantly reduce the deviation between the total output power and the target power, but also maintain the SOC of the hybrid energy storage system within a reasonable range.ConclusionsThis strategy can provide a useful reference for research related to smoothing wind power fluctuations.

C21H20Cl2N2O2, orthorhombic, P21 (no. 4), a = 8.3667(14) Å, b = 15.444(3) Å, c = 15.105(2) Å, V = 1951.9(6) Å3, Z = 4, Rgt (F) = 0.0481, wRref (F 2) = 0.1574, T = 292 K.

C21H25N3O2, triclinic, P1̄ (no. 2), a = 7.6536(6) Å, b = 11.027(1) Å, c = 12.6899(11) Å, α = 66.863(2)°, β = 80.598(2)°, γ = 71.772(2)°, V = 934.38(14) Å3, Z = 2, R gt(F) = 0.0679, wR ref(F 2) = 0.1150, T = 296 K.

ObjectiveTo improve the response capabilities to disasters and prevent major epidemics， it is of practical use to study the capability evaluation system of the national emergency medical rescue team that combines theoretical training and practical exercises， to enhance the overall quality of the teams.MethodsFirst， a capability assessment system for the national emergency medical rescue team was constructed based on the INSARAG External Classification （IEC） standards of the national emergency medical rescue team. Then， based on the outcome based education （OBE） concept， we conducted innovative research on the curriculum design and exercise programs for team building and member training. Finally， an empirical analysis was conducted on the effectiveness of the evaluation system and training exercises based on the statistical analysis of the comprehensive quality evaluation of the Shanghai national emergency medical rescue team from 2020 to 2023， as well as the empirical analysis of the rescue exercise on the Cruise of spectrum.ResultsBased on the linear regression analysis of each core competency indicators， the five core competencies in the evaluation system， including rescue skills， medical and health knowledge， disaster coping ability， team cooperation ability， and mental resilience training， were positively correlated with the cumulative number of trainings （r=0.71， r=0.76， r=0.81， r=0.84， r=0.96，all P

Accumulating evidence shows that Schwann cells’ (SCs) death caused by high glucose (HG) is involved in the pathological process of diabetic peripheral neuropathy (DPN). Ferroptosis is a novel form of regulatory cell death driven by iron-dependent lipid peroxidation. However, it is not clear whether ferroptosis is involved in the death process of SCs induced by HG. The expression of ferroptosis-related indicators in the serum of DPN patients was detected by ELISA. Subsequently, using cell counting kit‑8, western blot, real-time PCR, and Ki-67 staining, we investigated the effects of HG on the ferroptosis of SCs and initially explored the underlying mechanism. The results showed that the serum levels of glutathione peroxidase 4 (GPX4) and glutathione in patients with DPN decreased, while malondialdehyde levels increased significantly. Then, we observed that erastin and HG induced ferroptosis in SCs, resulting in the decrease in cell activity and the expression level of GPX4 and SLC7A11, which could be effectively reversed by the ferroptosis inhibitor Fer-1. Mechanistically, HG induced ferroptosis in SCs by inhibiting the NRF2 signaling pathway. Our results showed that ferroptosis was involved in the death process of SCs induced by HG. Inhibition of ferroptosis in SCs might create a new avenue for the treatment of DPN.

As big data mining technology is known to directly change the development direction and internal management, and the behaviour of college students’ political wisdom network has also changed significantly, hence the application and analysis of data mining technology becomes indispensable. Bidirectional gated cyclic cell network can solve the gradient disappearance or gradient explosion existing in traditional models, but can also make up for the deficiency of extracting the contextual semantic information of long text effectively. Using the combination of big data-based mining technology and college students’ network ideology and politics, this paper designed a set of BiGRU_Attention framework based on college students’ network ideological wisdom framework and adopted big data mining technology to collect data. First, according to the Internet technology and information collection, design a complete set of college students’ ideological wisdom framework. Then, the GRU structure, BiGRU framework and Attention mechanism combined with BiGRU_Attention model are introduced. Meanwhile, Word2Vec is used to train the Chinese word vector. Finally, the BiGRU_Attention proposed in this paper is compared with several models. Experimental results show that the BiGRU_Attention proposed in this paper has a better accuracy of 96.32% over other models. The experimental results also show that the framework of ideological and political intelligence proposed in this paper can be applied to the campus environment of college students.

Objective To investigate the survival outcomes and risk factors of patients with stage ⅡB cervical cancer undergoing neoadjuvant chemotherapy (NACT) followed by laparoscopic radical hysterectomy (LRH). Methods A retrospective cohort study was conducted on 178 patients with stage ⅡB cervical cancer who underwent NACT followed by LRH in our department from 2015 to 2018. COX regression analysis was used to analyze the surgical pathological characteristics, and stratified analysis was performed according to the results. Kaplan-Meier survival curve analysis and log-Rank test were employed to analyze the survival outcomes of different subgroups. Results For the 178 subjected patients, their median follow-up period was 51 months, and the rates of 3-year disease-free survival (DFS) and overall survival (OS) were 75.4% and 82.6%, respectively. COX regression analysis showed that lymph node metastasis (LNM) (HR: 2.04, 95%CI: 1.16~3.60) and deep stromal invasion (DSI) (HR: 4.72, 95%CI: 2.11~10.60) were independent risk factors for DFS. LNM (HR: 2.77, 95%CI: 1.48~5.22), DSI (HR: 4.24, 95%CI: 1.64~10.98) and tumor diameter ≥4 cm after NACT (HR: 2.12, 95%CI: 1.14~3.94) were independent risk factors for OS. The rates of 3-year DFS of patients with and without LNM was 55.3% and 81.0% (P < 0.001), and the rates of 3-year OS was 64.8% and 87.7% (P < 0.001), respectively. The rates of 3-year DFS of patients with and without DSI were 64.1% and 92.8% (P < 0.001), and the rates of 3-year OS were 73.2% and 95.7% (P < 0.001), respectively. There was no significant difference in DFS between patients with tumor diameter < 4 cm and ≥4 cm after NACT, while the rates of 3-year OS was 85.1% and 74.4%, respectively (P=0.028). The DFS and OS of patients with tumor diameter reduction >50% after NACT were significantly better than those ≤50% (the 3-year DFS rate: 92.9% vs 71.0%, P < 0.001; the 3-year OS rate: 93.0% vs 82.4%, P=0.017). Conclusion Patients with stage ⅡB cervical cancer with tumor diameter reduced by >50% after NACT have better survival outcomes. LNM, DSI and tumor diameter ≥4 cm after NACT are independent risk factors for the prognosis of stage ⅡB cervical cancer.

Background Echocardiogram is commonly used to evaluate cardiac remodeling in hypertension (HTN). However, study on echocardiographic phenotypes and their prognostic implications in HTN is limited. Objective We aimed to evaluate the prognostic implications echocardiographic phenotypes in community hypertensive patients. Method A total of 1881 community hypertensive patients without overt cardiovascular disease and severe renal disease (mean age 62.8 years, women 57.9%) were included. Using Two-Step cluster analysis with four conventional echocardiographic variables, two clusters with distinct echocardiographic phenotypes were identified. Result The Cluster 1 (namely “mild-remodeling” HTN; n = 1492) had low prevalence of enlarged left atrium (LA; 0.9%) and left ventricular hypertrophy (LVH; 16.2%) and better LV diastolic function. They were younger and more likely to be men and had lower comorbid burden. The Cluster 2 (namely “severe-remodeling” HTN; n = 389) had higher prevalence of enlarged LA (26.0%) and LVH (83.0%) and worse LV diastolic function. They were older and more likely to be women and had higher comorbid burden. After a median follow-up of 4.2 years, compared to the Cluster 1, the Cluster 2 had higher incidence of cardiovascular (4.1% vs 1.7%; P = .006) and all-cause (9.8% vs 4.8%; P

Abstract Aim The aim of this study was to modify and test the psychometric properties of the Chinese version of the stressor scale for emergency nurses. Design The methodological design was carried out in two phases: (a) form the Chinese version by Delphi method and (b) test the psychometric properties by cross‐sectional survey. Methods The translated scale was administered to 420 nurses in Qingdao. Validity was assessed in terms of content validity, calibration correlation validity and construct validity using exploratory factor analysis and confirmatory factor analysis. Internal consistency was estimated using Cronbach α coefficients. Results The Chinese version of the SSEN retains 27 items, four common factors were extracted by exploratory factor analysis, and the factor cumulative variance contribution rate was 78.463%. The fitting indexes of the four‐factor model of CFA were all in the acceptable range[χ2 = 711.30, df = 312, p

Abstract Background Cell death and inflammation are the two important triggers of wear particle-induced osteolysis. Particles, including cobalt-chromium-molybdenum and tricalcium phosphate, have been reported to induce pyroptosis in macrophages and osteocytes. Although macrophage pyroptosis facilitates osteoclastic bone resorption and osteolysis, whether osteocyte pyroptosis is involved in osteoclastic osteolysis still needs further investigation. Desferrioxamine (DFO), an FDA-approved medication and a powerful iron chelator, has been proven to reduce ultrahigh-molecular-weight polyethylene (UHMWPE) particle-induced osteolysis. However, whether DFO can ameliorate UHMWPE particle-induced osteolysis by decreasing pyroptosis in osteocytes is unknown. Results A mouse calvarial osteolysis model and the mouse osteocyte cell line MLO-Y4 was used, and we found that pyroptosis in osteocytes was significantly induced by UHMWPE particles. Furthermore, our findings uncovered a role of caspase-1-dependent pyroptosis in osteocytes in facilitating osteoclastic osteolysis induced by UHMWPE particles. In addition, we found that DFO could alleviate UHMWPE particle-induced pyroptosis in osteocytes in vivo and in vitro. Conclusions We uncovered a role of caspase-1-dependent pyroptosis in osteocytes in facilitating osteoclastic osteolysis induced by UHMWPE particles. Furthermore, we found that DFO alleviated UHMWPE particle-induced osteoclastic osteolysis partly by inhibiting pyroptosis in osteocytes. Graphical Abstract Schematic of DFO reducing UHMWPE particle-induced osteolysis by inhibiting osteocytic pyroptosis. Wear particles, such as polymers, generated from prosthetic implant materials activate canonical inflammasomes and promote the cleavage and activation of caspase-1. This is followed by caspase-1-dependent IL-β maturation and GSDMD cleavage. The N-terminal fragment of GSDMD binds to phospholipids on the cell membrane and forms holes in the membrane, resulting in the release of mature IL-β and inflammatory intracellular contents. This further facilitates osteoclastic differentiation of BMMs, resulting in excessive bone resorption and ultimately leading to prosthetic osteolysis. DFO reduces UHMWPE particle-induced osteolysis by inhibiting osteocytic pyroptosis.

As radiation therapy is increasingly utilized in the treatment of cancer, neuropathic pain (NP) is a common radiotherapy-related adverse effect and has a significant impact on clinical outcomes negatively. However, despite an improved understanding of neuropathic pain management, pain is often undertreated in patients with cancer. Herein, we reported two cases with radiotherapy-related neuropathic pain (RRNP) who presented a positive reaction to acupuncture. Patient 1 (a 73-year-old woman) with gynecologic cancer complained of burning and electric shock-like pain in the lower limb after radiotherapy. With the accepted combination of acupuncture and drugs, the pain was alleviated completely in 8 weeks. Patient 2 (a 64-year-old woman) accepted acupuncture in the absence of medication because of her inability to tolerate the adverse events of anticonvulsant drugs. She achieved remission of pain 4 weeks later. The results of this study showed that acupuncture might be promising for controlling the RRNP in patients with cancer, especially who were intolerant or unresponsive to medications.

Relevance. Economic activity in the wetlands of Western Siberia in the conditions of climate change requires scientific justification of both methods of environmental monitoring and environmental protection measures. One of the effective ways of such justification, taking into account the lack of observations, is mathematical modeling of hydrogeodynamical and hydrogeochemical processes in fen ecosystems. The aim of the research is to identify the mechanisms of natural-technogenic distribution of Cl–-concentrations in water extracts from peat over the depth of peat deposits. Methods: field experiment, methods of definition of a chemical composition of peat and water, methods of mathematical modeling. Results and conclusions. An experiment was conducted to study the self-purification of the eutrophic Obskoe fen in the south of the Tomsk region (release of 50 liters of NaCl solution with a concentration of 20 g/dm3 to the fen surface), and the nature of changes in Cl–-concentrations in peat deposits before and after the release of the solution was established. To explain the revealed facts, mathematical models of the water and geochemical regime of the peat fen site were developed and tested. As a result, it is shown that: 1) fen waters form a common flow with groundwater towards the Ob river; periodic fluctuations in groundwater pressure are possible at the border of the fen; 2) in the lower part of the peat deposit, a local water barrier has formed in the study area, preventing the spread of substances in a peat deposit; 3) distribution of the indicator (Cl–) over the peat deposit largely depends not only on the initial volume and concentration of NaCl and the presence of a water barrier, but also on the nature of the wetness of the fen. Recommendations on the use of simulation results are given.

Based on the scientific theory of modern nutrition and functional food science, this paper uses biotechnology and information digital technology to establish a more precise, flexible, integrated and digital functional food research and development system-flexible precise nutrition intervention system （FPNIS） which improves the shortcomings of the two common functional food research and development models that are based on traditional Chinese herbal medicines or simple ingredient dietary supplements. Through the establishment of FPNIS, provide a new way to explore the research and development of efficient and precise functional food, and analyze its trend.

The relevance of the research is determined by the need to take into account the interactions of river waters with bottom sediments when normalizing anthropogenic impacts on water bodies. The aim of the research is to develop the model of transformation of polluting substances in water objects with the account of waste dilution and interaction of river waters and sediments and development of sewage normalization technique. Methods: mathematical modelling of hydrochemical processes. Results and conclusions. The mathematical model of transformation of polluting substances in water objects with the account of sewage dilution interaction of river waters and river sediments is developed. Its approbation by the example of the small rivers in northern part of Vietnam (the Ban Thi and Dai rivers in the Hong river basin) has shown that the chemical composition of waters of researched rivers is determined more than on 60 % by interactions of river waters with sediments as a result of sedimentation of poorly soluble substances and sorbtion of some trace elements. It results in appreciable decrease of concentration of many substances on sites up to 4,5–5,0 kms. Influence of water flow is shown first of all, in changes of a bed-material discharge, to a lesser degree it is a regulation of intrawater processes for which more long time of balance establishment in a solution is required. On the basis of the offered model its simplified version and a technique of normalization of sewage for variants of presence and absence of observation data is developed. Thus, the influence of interactions with river sediments is taken into account indirectly through structure of model and value of its parameters. Approbation of the simplified model is executed on the example of the Jinjiang river in the Poyang lake basin (China).

Background: The aim of this study was to investigate the effect of the stage of dental development on the treatment outcome of maxillary protraction in skeletal Class III children.

A growing corpus of evidence implicates the involvement of the commensal microbiota and immune cytokines in the initiation and progression of systemic lupus erythematosus (SLE). Glucocorticoids have been widely used in the treatment of SLE patients, however, glucocorticoid treatment carries a higher risk of other diseases. Using the 16S rRNA technique, we investigated the differences between the gut microbiota associated with the immune cytokines of SLE and relevant glucocorticoid treatment in a female cohort of 20 healthy control subjects (HC), 17 subjects with SLE (SLE-G), and 20 SLE patients having undergone glucocorticoid treatment (SLE+G). We observed that the diversity and structure of the microbial community in SLE+G patients were significantly changed compared to that of SLE-G patients, whereas the gut microbial community of the SLE+G group showed a similarity with the HC group, which implicate that the shift in the gut microbiome could represent a return to homeostasis. Furthermore, the up-regulations of immune cytokines in SLE-G were identified as closely related to gut dysbiosis, which indicates that the overrepresented genera in SLE patients may play roles in regulating expression level of these immune cytokines. This associated analysis of gut microbiota, glucocorticoid therapy, and immune factors might provide novel and insightful clues revealing the pathogenesis of SLE patients.

Autism Spectrum Disorder (ASD) is a severe neurodevelopmental disorder. To enhance the understanding of the gut microbiota structure in ASD children at different ages as well as the relationship between gut microbiota and fecal metabolites, we first used the 16S rRNA sequencing to evaluate the gut microbial population in a cohort of 143 children aged 2–13 years old. We found that the α-diversity of ASD group showed no significant change with age, while the TD group showed increased α-diversity with age, which indicates that the compositional development of the gut microbiota in ASD varies at different ages in ways that are not consistent with TD group. Recent studies have shown that chronic constipation is one of the most commonly obvious gastrointestinal (GI) symptoms along with ASD core symptoms. To further investigate the potential interaction effects between ASD and GI symptoms, the 30 C-ASD and their aged-matched TD were picked out to perform metagenomics analysis. We observed that C-ASD group displayed decreased diversity, depletion of species of Sutterella, Prevotella, and Bacteroides as well as dysregulation of associated metabolism activities, which may involve in the pathogenesis of C-ASD. Consistent with metagenomic analysis, liquid chromatography-mass spectrometry (LC/MS) revealed some of the differential metabolites between C-ASD and TD group were involved in the metabolic network of neurotransmitters including serotonin, dopamine, histidine, and GABA. Furthermore, we found these differences in metabolites were associated with altered abundance of specific bacteria. The study suggested possible future modalities for ASD intervention through targeting the specific bacteria associated with neurotransmitter metabolism.

The genetic variations and dysbiosis of gut microbiota are associated with ASD. However, the role of the microbiota in the etiology of ASD in terms of host genetic susceptibility remains unclear. This study aims to systematically explore the interplay between host genetic variation and gut microbiota in ASD children. Whole-exon sequencing was applied to 26 ASD children and 26 matched controls to identify the single nucleotide variations (SNVs) in ASD. Our previous study revealed alteration in gut microbiota and disorder of metabolism activity in ASD for this cohort. Systematic bioinformatic analyses were further performed to identify associations between SNVs and gut microbiota, as well as their metabolites. The ASD SNVs were significantly enriched in genes associated with innate immune response, protein glycosylation process, and retrograde axonal transport. These SNVs were also correlated with the microbiome composition and a broad aspect of microbial functions, especially metabolism. Additionally, the abundance of metabolites involved in the metabolic network of neurotransmitters was inferred to be causally related to specific SNVs and microbes. Furthermore, our data suggested that the interaction of host genetics and gut microbes may play a crucial role in the immune and metabolism homeostasis of ASD. This study may provide valuable clues to investigate the interaction of host genetic variations and gut microbiota in the pathogenesis of ASD.

ABSTRACT Disturbances of sleep and the underlying circadian rhythm are related to many human diseases, such as obesity, diabetes, cardiovascular disorders, and cognitive impairments. Dysbiosis of the gut microbiome has also been reported to be associated with the pathologies of these diseases. Therefore, we proposed that disturbed sleep may regulate gut microbiota homeostasis. In this study, we mimicked the sleep-wake cycle shift, one typical type of circadian rhythm disturbances in young people, in recruited subjects. We used 16S rRNA gene amplicon sequencing to define microbial taxa from their fecal samples. Although the relative abundances of the microbes were not significantly altered, the functional-profile analysis of gut microbiota revealed functions enriched during the sleep-wake cycle shift. In addition, the microbial networks were quite distinct among baseline, shift, and recovery stages. These results suggest that an acute sleep-wake cycle shift may exert a limited influence on the gut microbiome, mainly including the functional profiles of the microbes and the microbial relationships within the microbial community. IMPORTANCE Circadian rhythm misalignment due to social jet lag, shift work, early morning starts, and delayed bedtimes is becoming common in our modern society. Disturbances of sleep and the underlying circadian rhythms are related to multiple human diseases, such as obesity, diabetes, cardiovascular disorders, and cognitive impairments. Given the crucial role of microbiota in the same pathologies as are caused by sleep disturbance, how the gut microbiota is affected by sleep is of increasing interest. The results of this study indicate that the acute circadian rhythm disturbance caused by sleep-wake shifts affect the human gut microbiota, especially the functional profiles of gut microbes and interactions among them. Further experiments with a longer-time-scale intervention and larger sample size are needed to assess the effects of chronic circadian rhythm disruption on the gut microbiome and to guide possible microbial therapies for clinical intervention in the related diseases.

Triassic strata are widely developed in the eastern part of Sichuan Basin. The Mingyuexia anticline and Huangnitang anticline located in the eastern Sichuan structural belt develop Triassic Jialingjiang Formation to Xujiahe Formation. The middle Triassic Leikoupo Formation and Badong Formation on both sides of the anticline are synchronous and heterogeneous strata. They are distinguished regionally according to their different sedimentary environments and lithologic characteristics, and the phase transition boundary between Leikoupo Formation and Badong Formation is determined.

Salmonella infection is a major public health concern, and colonization in humans can be chronic and increases the risk of cancers. Wnt signaling is a key pathway for intestinal renewal and development, inflammation, and tumorigenesis. In the current study, we report a novel role of Wnt1 in infection and colon cancer using cell culture models, a Salmonella-colitis colon cancer model, and human samples. In contrast to the bacteria-induced increases in Wnt2 and Wnt11, Salmonella colonization significantly reduced the level of Wnt1 in intestinal epithelial cells in vivo and in vitro. The bacterial AvrA protein is known to activate the canonical Wnt pathway. Wnt1 expression level was downregulated by AvrA-expressing Salmonella but stabilized by AvrA-deficient Salmonella in the intestine of Salmonella-colitis mice. In a chronic Salmonella-infected cancer model, the Wnt1 protein level was decreased in the AvrA+ infected group. Thus, we further assessed the functional role of Wnt1 downregulation in the inflammatory response and colorectal cancer (CRC) progression. Moreover, downregulation of Wnt1 by the Crispr-Cas9 method affected cancer cell invasion and migration. Interestingly, we found that Wnt1 was downregulated in human CRC tissue, and Wnt1 downregulation may be correlated with cancer progression. Our study provides insights into mechanisms by which enteric bacteria regulate Wnt1 expression and potentially contribute to infection-associated colon cancer.

With the increase of grid-connected PV capacity, voltage regulation at point of common coupling by controlling the reactive power injected into the grid is available. This paper presents an adaptive voltage control strategy for distribution network with high proportion PV system. The PI gain of the voltage controller is automatically adjusted by the extremum seeking algorithm to dynamically respond to the changes of the network. The PI gains are updated online through the minimization of a cost function, which represents the voltage controller performance. Finally, a distribution network model of 5 MW photovoltaic power generation system is built in MATLAB / Simulink to verify the effectiveness of the proposed control strategy.

China’s coastal areas are rich in wind energy resources, and there is a huge market demand for wind power generators. However, due to the impact of typhoons every summer, the wind farms are cut off, causing serious damage to the wind turbines and causing significant economic losses. Based on optimizing the yaw system under typhoon conditions, this paper configures and selects the capacity of diesel generators. First, this article introduces the structure and main functions of the yaw control system. Secondly, through the study of the under-stage wind field model, the algorithm of wind speed extreme value and the calculation method of yaw angle and yaw direction are proposed, and hill climbing algorithm is introduced to optimize the work of the yaw control system. Then, a method for calculating the actual power of a single yaw control system is introduced. On this basis, the capacity configuration plan of the standby diesel generator set was determined, so that it can meet the normal yaw work of the whole field yaw system in the event of a power outage in the field to ensure the safety of the wind turbine.

As the heart of the sea booster station, the transformer has an extremely important position. When the transformer has various faults, it is very easy to cause a fire accident, so the safe operation of the transformer is very important. First, use the fault tree analysis method to construct a transformer fire fault tree evaluation model for different types of fire fault events during the operation of the transformer, then through the calculation of the fire failure probability, the number of measuring points of the composite fire detector is obtained and the measuring points are reasonably arranged to detect the operation status of the transformer in real time. Therefore, it is of great significance to ensure the safe and reliable operation of offshore booster station by improving the accuracy of transformer fire warning.

Hypoxia not only plays a critical role in multiple disease conditions; it also influences the growth and development of cells, tissues and organs. To identify novel hypoxia-related mechanisms involved in cell and tissue growth, studying a precise hypoxia-sensitive time window can be an effective approach. Drosophila melanogaster has been a useful model organism for studying a variety of conditions, and we focused in this study on the life cycle stages of Drosophila to investigate their hypoxia sensitivity. When normoxia-grown flies were treated with 4% O2 at the pupa stage for 3, 2 and 1 day/s, the eclosion rates were 6.1%, 66.7% and 96.4%, respectively, and, when 4% O2 was kept for the whole pupa stage, this regimen was lethal. Surprisingly, when our hypoxia-adapted flies who normally live in 4% O2 were treated with 4% O2 at the pupa stage, no fly eclosed. Within the pupa stage, the pupae at 2 and 3 days after pupae formation (APF), when treated for 2 days, demonstrated 12.5 ± 8.5% and 23.6 ± 1.6% eclosion, respectively, but this was completely lethal when treated for 3 days. We conclude that pupae, at 2 days APF and for a duration of a minimum of 2 days, were the most sensitive to hypoxia. Our data from our hypoxia-adapted flies clearly indicate that epigenetic factors play a critical role in pupa-stage hypoxia sensitivity.

Jade-like cryptocrystalline-microcrystalline vein quartzite is called quartzite jade in the jewel business of China. Color is the main criteria for the value of quartzite jade, and therefore studying the coloration mechanism is very important for the color evaluation index and ore genesis. Previous studies have shown that the accurate information of color causing minerals cannot be acquired. The synchrotron radiation techniques, BL15U1 in SSRF equipped with μ-XRF and μ-XRD at SSRF were used for studying the color causing minerals in vein quartzite and are reported in this paper. It was found that yellow vein quartzite is colored by goethite (characteristic diffraction peaks at 0.49574, 0.41594, 0.26887, 0.25705, 0.25189, 0.24510, 0.21806, 0.17133 nm), whereas red quartzite is colored by hematite (characteristic diffraction peaks at 0.36774, 0.27091, 0.25200 nm). Yellow-red quartzite is colored by both goethite and hematite and hematite has a stronger coloration ability than goethite. This study provides direct data of the color causing minerals in quartzite jade, which is useful for discussing the crystallization conditions and the coloration mechanism, and also helpful for the quality evaluation of quartzite jade.

Quartzite jade is composed of α-quartz and another silica phase, moganite, which forms under low pressure and low temperature conditions. At present, there are few studies on the relationship between the relative content of moganite and the crystallinity of quartzite jade. In this study, some quartzite jade samples from four locations in China(Longling, Yunnan province; Huoshan, Anhui province; Hezhou, Guangxi Zhuang Autonomous Region, and Alxa League, Inner Mongolia Autonomous Region), were analyzed by Raman Scattering Spectroscopy, Infrared Absorption Spectroscopy and X-ray Powder Diffraction techniques. The results showed a negative correlation between the relative content of moganite and the crystallinity of quartzite jade. The higher the relative content of moganite, the lower is the crystallinity index of quartzite jade. The relationship of the intensity ratio of 502 cm-1/465 cm-1 in the Raman scattering spectrum and the crystallinity index of quartzite jade, could be expressed by the equation of Y=-0.36X+6.93(the correlation coefficient is-0.94). This research could not only offer some new ideas about qualitatively estimating the crystallinity of quartzite jade by non-destructive testing methods, but also provide some scientific evidence and theoretical restrictions for qualitatively evaluating quartzite jade.

In order to obtain the effects of size parameters on meshing performance of the main reduction gear in a car,the response parameters of gear meshing are obtained by using the explicit finite element method.The response surface model of meshing response parameters of thegear size parameters are established based on the Kriging model. The main reducing gear parameter optimization are carried out by using the NSGA- Ⅱ multi- objective optimization genetic algorithm in which the tooth root bending stress,tooth surface contact stress and volume of the gears are defined as objective function,the solution set of the gears parameters are obtained. The meshing stress level of main reduction gears decreased significantly after the optimization.