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26 results on '"Zhou, Zhangzhe"'

4. Identification of osteoporosis based on gene biomarkers using support vector machine

Author

Lv Nanning, Zhou Zhangzhe, He Shuangjun, Shao Xiaofeng, Zhou Xinfeng, Feng Xiaoxiao, Qian Zhonglai, Zhang Yijian, and Liu Mingming

Subjects
osteoporosis, differentially expressed genes, weighted gene co-expression network analysis, protein–protein interaction, support vector machine, Medicine
Abstract

Osteoporosis is a major health concern worldwide. The present study aimed to identify effective biomarkers for osteoporosis detection. In osteoporosis, 559 differentially expressed genes (DEGs) were enriched in PI3K-Akt signaling pathway and Foxo signaling pathway. Weighted gene co-expression network analysis showed that green, pink, and tan modules were clinically significant modules, and that six genes (VEGFA, DDX5, SOD2, HNRNPD, EIF5B, and HSP90B1) were identified as “real” hub genes in the protein–protein interaction network, co-expression network, and 559 DEGs. The sensitivity and specificity of the support vector machine (SVM) for identifying patients with osteoporosis was 100%, with an area under curve of 1 in both training and validation datasets. Our results indicated that the current system using the SVM method could identify patients with osteoporosis.

Published
2022
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8. A Self‐Adaptive Biomimetic Periosteum Employing Nitric Oxide Release for Augmenting Angiogenesis in Bone Defect Regeneration

Author

Zhou, Zhangzhe, primary, Liu, Yang, additional, Li, Wenjing, additional, Zhao, Zhijian, additional, Xia, Xiaowei, additional, Liu, Junlin, additional, Deng, Yaoge, additional, Wu, Yubin, additional, Pan, Xiangqiang, additional, He, Fan, additional, Yang, Huilin, additional, Lu, Weihong, additional, Xu, Yong, additional, and Zhu, Xuesong, additional

Published
2023
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14. Comparing the Bridge‐Type Zero‐Profile Anchored Spacer ( ROI‐C ) Interbody Fusion Cage System and Anterior Cervical Discectomy and Fusion ( ACDF ) with Plating and Cage System in Cervical Spondylotic Myelopathy

Author

He, Shuangjun, primary, Zhou, Zhangzhe, additional, Shao, Xiaofeng, additional, Zhou, Lijian, additional, Zhang, Changhao, additional, Zhou, Xinfeng, additional, Wu, Shuhua, additional, Chen, Kangwu, additional, Wang, Yaowei, additional, and Qian, Zhonglai, additional

Published
2022
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17. Comparison of Clinical Outcomes Following Anterior Cervical Discectomy and Fusion with Zero-Profile Anchored Spacer-ROI-C-Fixation and Combined Intervertebral Cage and Anterior Cervical Discectomy and Fusion: A Retrospective Study from a Single Center

Author

He, Shuangjun, primary, Zhou, Zhangzhe, additional, Lv, Nanning, additional, Shao, Xiaofeng, additional, Zhou, Xinfeng, additional, Wang, Yaowei, additional, Wu, Shuhua, additional, Chen, Kangwu, additional, Zhou, Lijian, additional, and Qian, Zhonglai, additional

Published
2021
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20. A Comparison of the Bridge-type ROI-C Interbody Fusion Cage System and Titanium Mesh Graft With Titanium Plate Fixation in 2-level Anterior Cervical Discectomy and Fusion With Plating and Cage System: A Retrospective Study

Author

He, Shuangjun, primary, Zhou, Zhangzhe, additional, Shao, Xiaofeng, additional, Zhang, Changhao, additional, Zhou, Xinfeng, additional, Wu, Shuhua, additional, Chen, Kangwu, additional, Wang, Yaowei, additional, and Qian, Zhonglai, additional

Published
2020
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25. Cystine dimethyl ester cross-linked PEG-poly(urethane-urea)/nano-hydroxyapatite composited biomimetic scaffold for bone defect repair.

Author

Zhou, Zhangzhe, Wang, Yimeng, Qian, Yuqing, Pan, Xiangqiang, Zhu, Jian, Zhang, Zhengbiao, Qian, Zhonglai, Sun, Zhiyong, and Pi, Bin

Subjects
*DIMETHYL sulfate, *CYSTINE, *SCANNING electron microscopy, *BONE regeneration, *ELASTOMERS, *GLYCOLIC acid, *CALCIUM phosphate
Abstract

Polyurethane (PU) and polyurea (PUA) materials have shown significant potential for application in tissue repair. Herein, we design a glycerol ethoxylate (PEG)-based poly(urethane-urea) for bone tissue repair. The polymer precursor was prepared from the reaction of PEG and isophorone diisocyanate (IPDI). The cystine dimethyl ester was used as a cross-linker for the preparation of poly(urethane-urea) elastomers. The material was further strengthened by physical blending of nano-hydroxyapatite (nHA). The physical and biological properties of final material were evaluated by mechanical testing, scanning electron microscopy characterization, degradation tests, cell proliferation and cell differentiation assays. The obtained scaffolds showed good mechanical strength, excellent biocompatibility and osteogenic capability. All the evidences demonstrated that this type of materials has good prospects for bone tissue repair application. [ABSTRACT FROM AUTHOR]

Published
2020
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26. Kyphoplasty for occult and non-occult osteoporotic vertebral fractures: a retrospective study

Author

Zhou, Zhangzhe, Sun, Zhiyong, Wang, Yimeng, Zhu, Xiaoyu, and Qian, Zhonglai

Abstract

Objective To compare the safety and efficacy of kyphoplasty in the treatment of occult and non-occult osteoporotic vertebral compression fractures (OOVF).Material and Methods From 2015 to 2017, 82 OOVF and 105 non-occult osteoporotic vertebral compression fractures (N-OOVF) were evaluated with the Visual Analog Scale (VAS), Oswestry Disability Index (ODI), and vertebral height preoperatively, immediately postoperatively, and one year postoperatively. Operative time, fluoroscopy time, and cement injection volume were recorded.Results Compared with the preoperative VAS and ODI scores, the scores of both groups were significantly improved after surgery. Preoperative ODI and VAS scores of the OOVF were lower than those of the N-OOVF. The operative time, fluoroscopy time, and bone cement injection volume of the OOVF were significantly lower than those of the N-OOVF. Vertebral height of the N-OOVF improved significantly after surgery. There were differences in cement leakage and adjacent vertebral fractures between the two groups.Conclusion Compared with N-OOVF, OOVF are safer with kyphoplasty, and it is necessary to diagnose OOVF in a timely manner.

Published
2020
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