Search

Your search keyword '"Zhou, Yali"' showing total 774 results
Start Over Author "Zhou, Yali"
774 results on '"Zhou, Yali"'

3. Research Progress in Blood Pressure Management after Aortic Dissection

Author

LI Zhiyong, WANG Jing, ZHOU Yali, and YUAN Dong

Subjects
hypertension, aortic dissection, blood pressure management, Medicine
Abstract

Hypertension (HT) can induce aortic dissection (AD) by increasing the tension of the aortic wall and promoting tissue degradation, and continuous HT may increase the risk of aortic-related death. It is a significant factor in poor prognosis for AD and the most important controllable factor. Research has shown that blood pressure management after AD can reduce the incidence rate and mortality of AD, so controlling HT is an important goal and means of AD treatment. This article reviews the research progress on the impact of AD on blood pressure, the significance and methods of blood pressure management after AD, with the hope of providing reference for the treatment of AD patients and benefiting them.

Published
2024
Full Text
View/download PDF

14. Main group salen-based catalysts for lactide ring-opening polymerisation

Author

Zhou, Yali, Garden, Jennifer, and Cockcroft, Scott

Subjects
Lactide Ring-Opening Polymerisation, Salen-Based Catalysts, biodegradable polymers, polylactic acid, PLA
Abstract

Lactide ring-opening polymerisation (LA ROP) is an efficient route to convert biomass into biodegradable polylactic acid (PLA) with high molecular weight and well controlled polymer microstructure. So far, most catalyst development for LA ROP has focused on organometallic complexes; some have displayed high catalytic activities and exquisite polymerisation control. Salen-derived complexes have shown particular success in the preparation of PLA, and the ligand can be readily modified to fine-tune the sterics and electronics of the catalytic system. Heterometallic cooperativity offers an attractive alternative approach to modify the catalyst system via incorporating a second metal, yet remains relatively underexplored. Based on half- salen and TrenSal ligands, this work investigates the influence of ligand substituents and heterometal upon the catalyst activity and control in rac-LA ROP. Chapter 2 reports seven lithium half-salen complexes supported by sterically and electronically diverse phenolic substituents. The lithium complexes exhibit extremely high activities toward rac-LA ROP in the presence of co-initiator benzyl alcohol (BnOH) giving kobs values up to 4.46 min-1. However, the ortho-Cl/N-Me substituted complex, which features an unusual lithium phenoxyimine ladder structure, is completely inactive. The results highlight that the aggregation state can override the nature of the ligand substituents to affect the catalyst activity. Reactivity studies indicate that both coordination-insertion and activated monomer mechanisms are available depending on the absence or presence of the BnOH co-initiator, respectively generating cyclic or linear polymers. Chapter 3 describes four new homo- and heterometallic sodium and/or aluminium TrenSal complexes for rac-LA ROP. Reactivity studies suggest that the insertion of sodium to form the heterometallic Na/Al complex alters the aluminium geometry from octahedral to tetrahedral, switching from an inactive mono-Al complex to an active and controlled heterometallic catalyst for rac-LA polymerisation in the presence of BnOH (kobs = 3.19 × 10-2 min-1). Under identical conditions, homometallic mono- and tris-Na complexes show higher catalytic activities than the heterometallic analogue albeit with poorer polymerisation control. The tris-Na complex is extremely active (kobs = 1.21 min-1) but displays unusual second-order monomer dependency on LA, which is attributed to simultaneous coordination-insertion and activated monomer mechanisms. Combing sodium with aluminium improves the polymerisation control and also prevents these two mechanisms occurring simultaneously. Overall, the heterometallic Na/Al complex combines the outstanding catalytic activity (Na) and good control (Al) of homometallic analogues. Building upon the work in Chapter 3, Chapter 4 reports a series of novel homo- and heterobimetallic TrenSal complexes based on alkali metal (AM), magnesium and zinc. Most of the bimetallic catalysts outperform their monometallic analogues, displaying good activity and control for rac-LA ROP in the presence of BnOH (including Na/Mg, K/Mg, Na/Zn, K/Zn, Mg/Zn and Zn/Zn combinations). In contrast, the mono-Zn complex is completely inactive under the polymerisation conditions tested and the mono-AM complexes display poor polymerisation control. The choice of the AM is important, as the heterometallic complexes featuring larger potassium centres exhibit higher activity than the sodium analogues. The Zn-based heterometallic complexes are also significantly faster than the Mg-based heterometallic analogues, despite the similarity in the ionic radius and the almost identical molecular structures between relative analogues (e.g. Na/Mg and Na/Zn). Accordingly, the highest catalytic activity was observed with the K/Zn complex (kobs = 1.46 min-1). The incorporation of crown ether to the K/Zn complex leads to rearrangement of the molecular structure and slower catalytic activity towards LA ROP. This work suggests that heterometallic complexes with an AM in the outer pocket of the TrenSal ligand may improve the catalyst activity by increasing the accessibility and Lewis acidity of the monomer coordination sites, and may convert the mechanism from coordination-insertion to activated monomer.

Published
2022
Full Text
View/download PDF

26. Genetically modified CD7-targeting allogeneic CAR-T cell therapy with enhanced efficacy for relapsed/refractory CD7-positive hematological malignancies: a phase I clinical study

Author

Hu, Yongxian, Zhou, Yali, Zhang, Mingming, Zhao, Houli, Wei, Guoqing, Ge, Wengang, Cui, Qu, Mu, Qitian, Chen, Gong, Han, Lu, Guo, Tingting, Cui, Jiazhen, Jiang, Xiaoyan, Zheng, Xiujun, Yu, Shuhui, Li, Xiaolong, Zhang, Xingwang, Chen, Mingxi, Li, Xiuju, Gao, Ming, Wang, Kang, Zu, Cheng, Zhang, Hao, He, Xiaohong, Wang, Yanbin, Wang, Dongrui, Ren, Jiangtao, and Huang, He

Published
2022
Full Text
View/download PDF

29. Formation of Dune Field Landscape in North and North-West China during Plio-Pleistocene Transition (4–2 Ma) and the Long-term Evolution

Author

Lu, Huayu, primary, Xu, Zhiwei, additional, Zhang, Wenchao, additional, Zhang, Hanzhi, additional, Wang, Xiaoyong, additional, Yi, Shuangwen, additional, Lu, Qi, additional, Wu, Bo, additional, Zhou, Yali, additional, Wang, Yao, additional, Zhang, Xiaojian, additional, Feng, Han, additional, Chang, Xi, additional, Cui, Mengchun, additional, Lv, Nana, additional, Wang, Hanlin, additional, and Wang, Xianyan, additional

Published
2023
Full Text
View/download PDF

30. UDE-Based Robust Walking Control of a Bipedal Robot

Author

Cao, Guanqun, Zhang, Qizhi, Zhou, Yali, Angrisani, Leopoldo, Series Editor, Arteaga, Marco, Series Editor, Panigrahi, Bijaya Ketan, Series Editor, Chakraborty, Samarjit, Series Editor, Chen, Jiming, Series Editor, Chen, Shanben, Series Editor, Chen, Tan Kay, Series Editor, Dillmann, Rüdiger, Series Editor, Duan, Haibin, Series Editor, Ferrari, Gianluigi, Series Editor, Ferre, Manuel, Series Editor, Hirche, Sandra, Series Editor, Jabbari, Faryar, Series Editor, Jia, Limin, Series Editor, Kacprzyk, Janusz, Series Editor, Khamis, Alaa, Series Editor, Kroeger, Torsten, Series Editor, Li, Yong, Series Editor, Liang, Qilian, Series Editor, Martín, Ferran, Series Editor, Ming, Tan Cher, Series Editor, Minker, Wolfgang, Series Editor, Misra, Pradeep, Series Editor, Möller, Sebastian, Series Editor, Mukhopadhyay, Subhas, Series Editor, Ning, Cun-Zheng, Series Editor, Nishida, Toyoaki, Series Editor, Pascucci, Federica, Series Editor, Qin, Yong, Series Editor, Seng, Gan Woon, Series Editor, Speidel, Joachim, Series Editor, Veiga, Germano, Series Editor, Wu, Haitao, Series Editor, Zamboni, Walter, Series Editor, Zhang, Junjie James, Series Editor, and Deng, Zhidong, editor

Published
2022
Full Text
View/download PDF

45. Quantitative Analysis of Aeolian Sand Provenance: A Comprehensive Analysis in the Otindag Dune Field, Central Inner Mongolia, China.

Author

Cui, Yingying, Zhou, Yali, Lizaga, Ivan, Dong, Zhibao, Zhang, Jin, Liang, Aimin, Lü, Ping, and Feng, Tong

Subjects
LAKE sediments, WATERSHEDS, HEAVY minerals, SAND dunes, SEDIMENT transport
Abstract

The identification and quantification of aeolian sand contributions are essential for understanding the formation of dune fields and mechanisms of modern surface processes. In the present study, we take aeolian sand in the Otindag dune field (hereafter, often referred to as, simply, Otindag) as the research object. The dune field's immediate source is quantitatively identified based on heavy minerals and the Conservativeness Index (CI), Consensus Ranking (CR), and the Consistent Tracer Selection (CTS) method. The primary source area of the aeolian sand was found to be from the northwestern, upwind area of the Otindag (59 ± 14%), followed by the Yinshan Mountain (17 ± 10%) and the lake basin (23 ± 12%). The proposed sediment transport model elucidates that sediments from the upwind of the Otindag are directly transported from the northwest to the Otindag, where they are deposited. Materials from the southern Yinshan Mountains are carried by rivers to the southern edge of the Otindag, where they are subsequently transported by wind and ultimately deposited. The lake deposits within the Otindag also contribute to the aeolian sand supply under the influence of wind. This study demonstrates that the fingerprinting techniques of CI, CR, and CTS serve as successful strategies for conducting quantitative provenance research in dune fields. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

46. Fludarabine, busulfan, and melphalan conditioning regimen in allogeneic hematopoietic stem cell transplantation for adult patients with myeloid malignancies: A multicenter retrospective study.

Author

Jiang, Jieling, Li, Xiaofan, Wu, Dong, Lu, Quanyi, Miao, Kourong, Wang, Houcai, Li, Xiaoping, Chen, Yingnian, Zhou, Shiyuan, Zhou, Yali, Liao, Guiping, Jiang, Chuanhe, Yuan, Xiaohong, Zhao, Youshan, Chang, Chunkang, Chen, Jie, Zhu, Han, Ma, Ruye, Li, Nainong, and Yin, Xiaolin

Published
2024
Full Text
View/download PDF

49. COX-2/sEH dual inhibitor PTUPB suppresses glioblastoma growth by targeting epidermal growth factor receptor and hyaluronan mediated motility receptor

Author

Li, Junyang, Zhou, Yali, Wang, Handong, Gao, Yongyue, Li, Liwen, Hwang, Sung Hee, Ji, Xiangjun, and Hammock, Bruce D

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Oncology and Carcinogenesis, Brain Cancer, Biotechnology, Cancer, Brain Disorders, Rare Diseases, 2.1 Biological and endogenous factors, Aetiology, 5.1 Pharmaceuticals, Development of treatments and therapeutic interventions, cyclooxygenase-2, soluble epoxide hydrolase, epidermal growth factor receptor, hyaluronan mediated motility receptor, glioblastoma, Oncology and carcinogenesis
Abstract

AimsCyclooxygenase-2 (COX-2)/soluble epoxide hydrolase (sEH) dual inhibitor, PTUPB, has been demonstrated to inhibit angiogenesis, primary tumor growth and metastasis. The aim of this study is to investigate the effects of PTUPB on glioblastoma cells and xenograft model.ResultsWe show here that PTUPB inhibits glioblastoma cell proliferation and G1 phase cell cycle arrest in vitro, and suppresses the tumor growth and angiogenesis in vivo. The expression and activation of epidermal growth factor receptor (EGFR) and its downstream kinases, ERK1/2 and AKT, are reduced by PTUPB, indicating that the EGF/EGFR signaling pathway is a potential target. Moreover, PTUPB dramatically suppresses expression of hyaluronan mediated motility receptor (HMMR) in the glioblastoma cell lines and xenograft mouse model, suggesting that the HMMR is the other potential target.Materials and methodsCellular immunofluorescence assays were used for cell staining of actin fibers and HMMR. CCK-8 kit was used for cell proliferation assay. Cell-cycle analysis was performed by flow cytometry. Quantitative real-time PCR assay was performed to test mRNA level. Western blot analysis was used to test protein expression. Immunohistochemical staining assay was used for xenograft tumor tissue staining of Ki-67, CD31 and HMMR. The SPSS version 17.0 software was applied for statistical analysis.ConclusionsOur data demonstrate that PTUPB is a potential therapeutic agent to treat glioblastomas.

Published
2017

Catalog

Books, media, physical & digital resources
See catalog results