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141 results on '"Zhou, Ya‐Ping"'

4. Assisting Role of Pulmonary Hypostasis Phenomenon in Diagnosis of Drowning

Author

WU Jian, LI Zeng-qiang, DAI Wen-dao, ZHAO Jian, ZHOU Ya-ping, QUAN Guo-lin, ZHAO Qian-hao, MA Yan-bing, and CHENG Jian-ding

Subjects
forensic pathology, drowning, entering the water after death, pulmonary hypostasis, cadaveric signs, Medicine
Abstract

ObjectiveTo study the phenomenon of pulmonary hypostasis in corpses of various causes of death， and to explore the potential value of this phenomenon in assisting forensic pathological diagnosis of drowning.MethodsA total of 235 cases with clear cause of death through systematic autopsy were collected from January 2011 to June 2021 in Guangzhou. According to the location of body discovery, the cases were divided into the water body group （97 cases） and the non-water body group （138 cases）, and the water body group was further divided into the water drowning group （90 cases） and the water non-drowning group （7 cases）. Non-water body group was further divided into the non-water drowning group （1 case） and the non-water non-drowning group （137 cases）. Three senior forensic pathologists independently reviewed autopsy photos to determine whether there was hypostasis in the lungs. The detection rate of pulmonary hypostasis was calculated.ResultsThe detection rate of pulmonary hypostasis in the water drowning group （90 cases） was 0， and the negative rate was 100%. The detection rate of pulmonary hypostasis in the water non-drowning group （7 cases） was 100% and the negative rate was 0. The detection rate of pulmonary hypostasis in the water body group and in the non-water body group （after excluding 2 cases, 136 cases were calculated） was 7.22% and 87.50%， respectively. There were statistically significant differences in the detection rate of pulmonary hypostasis between water body group and non-water body group, and between water drowning group and water non-drowning group （P

Published
2022
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5. Relationship between Water Temperature and Floating Time of Aquatic Cadavers

Author

LI Xu, ZHOU Ya-ping, HE Shu-wen, and LIN Bin

Subjects
forensic pathology, drowning, floating corpse, water temperature, corpse floating time, Medicine
Abstract

ObjectiveTo study the relationship between water temperature and floating time of aquatic cadavers， providing a reference for more precise positioning and searching for floating corpses.MethodsThe floating model of guinea pig after drowning at 17-30 ℃ was established, and the floating times of carcasses were recorded. The collected data of 32 floating corpse cases in the Pearl River were sorted out and analyzed according to the floating time of corpses corresponding to each degree of water temperature. The relationship models between water temperature and the floating time of guinea pig carcass, and between that and the floating time of real cases were established.ResultsThe floating time of the cadaver was negatively correlated with water temperature. The power function fitting equation of the relationship between floating time and water temperature of guinea pig carcass was y=1×1015x-10.530（R2=0.871, P

Published
2022
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11. Prenatal stress modulates HPA axis homeostasis of offspring through dentate TERT independently of glucocorticoids receptor

Author

Liu, Meng-Ying, primary, Wei, Lu-Lu, additional, Zhu, Xian-Hui, additional, Ding, Hua-Chen, additional, Liu, Xiang-Hu, additional, Li, Huan, additional, Li, Yuan-Yuan, additional, Han, Zhou, additional, Li, Lian-Di, additional, Du, Zi-Wei, additional, Zhou, Ya-Ping, additional, Zhang, Jing, additional, Meng, Fan, additional, Tang, Yu-Lin, additional, Liu, Xiao, additional, Wang, Chun, additional, and Zhou, Qi-Gang, additional

Published
2022
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16. A novel LGI1 mutation causing autosomal dominant lateral temporal lobe epilepsy confirmed by a precise knock‐in mouse model

Author

Hu, Ping, primary, Wu, Dan, additional, Zang, Yan‐Yu, additional, Wang, Yan, additional, Zhou, Ya‐Ping, additional, Qiao, Fengchang, additional, Teng, Xiao‐Yu, additional, Chen, Jiang, additional, Li, Qing‐Qing, additional, Sun, Jia‐Hui, additional, Liu, TingTing, additional, Feng, Hao‐Yang, additional, Zhou, Qi‐Gang, additional, Shi, Yun Stone, additional, and Xu, Zhengfeng, additional

Published
2021
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25. A novel LGI1 mutation causing autosomal dominant lateral temporal lobe epilepsy confirmed by a precise knock‐in mouse model.

Author

Hu, Ping, Wu, Dan, Zang, Yan‐Yu, Wang, Yan, Zhou, Ya‐Ping, Qiao, Fengchang, Teng, Xiao‐Yu, Chen, Jiang, Li, Qing‐Qing, Sun, Jia‐Hui, Liu, TingTing, Feng, Hao‐Yang, Zhou, Qi‐Gang, Shi, Yun Stone, and Xu, Zhengfeng

Subjects
TEMPORAL lobe epilepsy, LABORATORY mice, EPILEPSY, ANIMAL disease models, PARTIAL epilepsy, VALPROIC acid, SECRETION, VAGUS nerve
Abstract

Aims: This study aimed to explore the pathomechanism of a mutation on the leucine‐rich glioma inactivated 1 gene (LGI1) identified in a family having autosomal dominant lateral temporal lobe epilepsy (ADLTE), using a precise knock‐in mouse model. Methods and Results: A novel LGI1 mutation, c.152A>G; p. Asp51Gly, was identified by whole exome sequencing in a Chinese family with ADLTE. The pathomechanism of the mutation was explored by generating Lgi1D51G knock‐in mice that precisely phenocopied the epileptic symptoms of human patients. The Lgi1D51G/D51G mice showed spontaneous recurrent generalized seizures and premature death. The Lgi1D51G/+ mice had partial epilepsy, with half of them displaying epileptiform discharges on electroencephalography. They also showed enhanced sensitivity to the convulsant agent pentylenetetrazole. Mechanistically, the secretion of Lgi1 was impaired in the brain of the D51G knock‐in mice and the protein level was drastically reduced. Moreover, the antiepileptic drugs, carbamazepine, oxcarbazepine, and sodium valproate, could prolong the survival time of Lgi1D51G/D51G mice, and oxcarbazepine appeared to be the most effective. Conclusions: We identified a novel epilepsy‐causing mutation of LGI1 in humans. The Lgi1D51G/+ mouse model, precisely phenocopying epileptic symptoms of human patients, could be a useful tool in future studies on the pathogenesis and potential therapies for epilepsy. [ABSTRACT FROM AUTHOR]

Published
2022
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29. Agomelatine: An Astounding Sui-generis Antidepressant?

Author

Naveed, Muhammad, Li, Lian-Di, Sheng, Gang, Du, Zi-Wei, Zhou, Ya-Ping, Nan, Sun, Zhu, Ming-Yi, Zhang, Jing, and Zhou, Qi-Gang

Abstract

Major depressive disorder (MDD) is one of the foremost causes of disability and premature death worldwide. Although the available antidepressants are effective and well tolerated, they also have many limitations. Therapeutic advances in developing a new drug's ultimate relation between MDD and chronobiology, which targets the circadian rhythm, led to a renewed focus on psychiatric disorders. In order to provide a critical analysis about antidepressant properties of agomelatine, a detailed PubMed (Medline), Scopus (Embase), Web of Science (Web of Knowledge), Cochrane Library, Google Scholar, and PsycInfo search was performed using the following keywords: melatonin analog, agomelatine, safety, efficacy, adverse effects, pharmacokinetics, pharmacodynamics, circadian rhythm, sleep disorders, neuroplasticity, MDD, bipolar disorder, anhedonia, anxiety, generalized anxiety disorder (GAD), and mood disorders. Agomelatine is a unique melatonin analog with antidepressant properties and a large therapeutic index that improves clinical safety. Published articles revealed that agomelatine is a melatonin receptors (MT1 and MT2) agonist and 5HT2C receptor antagonist. The effects receptors' on melatonin receptors enable the resynchronization of irregular circadian rhythms with beneficial effects on sleep architectures. In this way, agomelatine is accredited for its unique mode of action, which helps to exert antidepressant effects and resynchronize the sleep-wake cycle. To sum up, an agomelatine has not only antidepressant properties but also has anxiolytic effects.

Published
2022
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33. Anhydroicaritin improves diet-induced obesity and hyperlipidemia and alleviates insulin resistance by suppressing SREBPs activation

Author

Zheng, Zu-Guo, primary, Zhou, Ya-Ping, additional, Zhang, Xin, additional, Thu, Pyone Myat, additional, Xie, Zhi-Shen, additional, Lu, Chong, additional, Pang, Tao, additional, Xue, Bin, additional, Xu, Da-Qian, additional, Chen, Yan, additional, Chen, Xiao-Wei, additional, Li, Hui-Jun, additional, and Xu, Xiaojun, additional

Published
2016
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34. Measurement and theoretical analysis of the adsorption of supercritical methane on superactivated carbon

Author

Li Ming, Zhou Li, and Zhou Ya-ping

Subjects
chemistry.chemical_element, Thermodynamics, General Chemistry, Supercritical fluid, Methane, chemistry.chemical_compound, Adsorption, chemistry, Desorption, medicine, Freundlich equation, Supercritical adsorption, Carbon, Activated carbon, medicine.drug
Abstract

Adsorption/desorption isotherms of supercritical methane on superactivated carbon have been measured in the range of 0–10 MPa and 233–333 K (20 K interval). The reversibility of the physical adsorption process is acknowledged. The heat of adsorption of 16.5 kJ/mol is determined from the isotherms, and a new modeling strategy for isotherms with maximum is presented. The model yields fits to the experimental isotherms with precision of ±2%, maintaining the constancy of the characteristic energy of adsorption. The exponent of the model equation expresses the pore size distribution feature of the adsorbent. The density of the supercritical adsor-bate is evaluated as a parameter of the model. It is shown that the conventional isotherm theory works too at supercritical condition if the limit state of supercritical adsorption is introduced into isotherm modeling.

Published
2000

37. Clinical application of neck acupoints in acupuncture

Author

Tai Hao-qing and Zhou Ya-ping

Subjects
Dry needling, medicine.medical_specialty, Regional anatomy, Complementary and alternative medicine, business.industry, Acupuncture moxibustion, Physical therapy, medicine, Acupuncture, business, Surgery
Abstract

This paper deals with the regional anatomy of the neck and some common acupoints. Acupoint Renying (ST 9) is taken as an example to elaborate the needling techniques and needling precautions of neck acupoints.

Published
2005

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